ライフサイエンスコーパス: infiltrating cell

1 n was restricted to a subpopulation of tumor-infiltrating cells.

2 factors) produced by the tumor, stroma, and infiltrating cells.

3 examined for sialadenitis and salivary gland-infiltrating cells.

4 FN-gamma and MDP cotreatment on adhering and infiltrating cells.

5 myeloid, mesenchymal) and abundance of tumor infiltrating cells.

6 chemistry and was mostly associated with the infiltrating cells.

7 decline in the percentage of Foxp3(+) graft infiltrating cells.

8 usage, and cytokine production of granuloma-infiltrating cells.

9 IMP-1 mRNA was most prominently expressed by infiltrating cells.

10 esponse, nurse cells are rarely destroyed by infiltrating cells.

11 and resolution correlated with apoptosis of infiltrating cells.

12 es inhibit diabetes in cotransfer with islet-infiltrating cells.

13 CXCR3 was localized in vascular and infiltrating cells.

14 ked reduction in apoptotic activity of graft-infiltrating cells.

15 the antibody response produced by the local infiltrating cells.

16 stantia propria, which contained most of the infiltrating cells.

17 essed on synovial lining and endothelial and infiltrating cells.

18 d B7 and CD28 expression on subsets of graft-infiltrating cells.

19 rotection assay, and flow cytometry of graft infiltrating cells.

20 gh frequency of apoptosis persisted in graft-infiltrating cells.

21 in situ nick end labeling (TUNEL)+ apoptotic infiltrating cells.

22 immunoperoxidase staining of immature graft-infiltrating cells.

23 ture, and ICAM-1 and LFA-1 were expressed on infiltrating cells.

24 d probably provides the port of entrance for infiltrating cells.

25 present only a very minor fraction of tissue-infiltrating cells.

26 nstrated abundant CD2+, CD4+, and CD8+ graft-infiltrating cells.

27 nuclear leukocytes (PMN) are the predominant infiltrating cells.

28 ration in the cytokine gene profile of islet infiltrating cells.

29 resident muscle stem cells, hepatocytes, and infiltrating cells.

30 ned by immunohistochemical analysis of graft-infiltrating cells.

31 ) suppresses IL22RA2 expression in human CRC-infiltrating cells.

32 bility, presenting a metabolic challenge for infiltrating cells.

33 icates the delineation of brain-resident and infiltrating cells.

34 myeloid, mesenchymal) and abundance of tumor-infiltrating cells.

35 ear cells, rejected kidney tissue, and graft infiltrating cells.

36 an altered miRNA expression profile in lung-infiltrating cells.

37 ist (IL-1RA) that could be assigned to liver-infiltrating cells.

38 reaction, and characterization of intragraft infiltrating cells.

39 gest expression of CXCL16 was found on tumor-infiltrating cells.

40 system composed of both neoplastic and other infiltrating cells.

41 mediated the gelatinase activity observed in infiltrating cells.

42 ed increased vasculature and large number of infiltrating cells.

43 ohistochemistry evaluated immunophenotype of infiltrating cells.

44 or alter the magnitude or composition of CNS-infiltrating cells.

45 In graft-infiltrating cells, a significant expansion of chimeric

46 The initial infiltrating cells accumulate perivascularly in close pr

47 Th2 inflammation, CD22+ B cells and IgG4(+)-infiltrating cells accumulated in tumors, and IL-10, IL-

48 Analysis of infiltrating cells after adoptive transfer by the diabet

49 leen, peripheral blood leukocytes, and graft infiltrating cells after donor (WF) or third-party (Lewi

50 nd the functional immune reactivity of tumor-infiltrating cells after ex vivo exposure to ICB.

51 sed colon crypt hyperplasia and an influx of infiltrating cells along with gross changes to crypt arc

52 The infiltrating cells also help suppress virus replication

53 , we evaluated whether human CSF, apart from infiltrating cells, also contains T(RM) cells and CNS-re

54 ated difference in the presence of bile duct infiltrating cells and 3-nitrotyrosine in PBC with an in

55 g, donor B cells rapidly migrated from graft-infiltrating cells and appeared in systemic circulation

56 d by a significant decrease in the number of infiltrating cells and by a significant reduction in the

57 ess that involves both parenchymal and graft infiltrating cells and can lead to organ failure if inju

58 chemical staining were performed to identify infiltrating cells and cytokines.

59 reflect differences in numbers and types of infiltrating cells and degree of remodeling among the th

60 nor cytotoxic T lymphocyte activity of graft-infiltrating cells and host spleen cells assessed 8 days

61 Cytotoxic activity of graft-infiltrating cells and host spleen cells, and complement

62 Apoptotic death in graft-infiltrating cells and in areas of T-dependent lymphoid

63 at AqH had significantly increased number of infiltrating cells and increased levels of various cytok

64 Concurrently, in both infiltrating cells and keratinocytes, we observed increa

65 Numbers of infiltrating cells and levels of matrix metalloproteinas

66 The number of infiltrating cells and levels of proteins in the AqH wer

67 Mouse eyes were evaluated for infiltrating cells and major histocompatibility complex

68 ir expression correlates with elimination of infiltrating cells and microglia, not the myelinating ce

69 the Kaede mouse model to photoconvert tumor-infiltrating cells and monitor their movement out of the

70 Finally, increased infiltrating cells and myelin destruction was observed i

71 associated with enhanced apoptosis of graft-infiltrating cells and of cells in the spleen where inte

72 s, and macrophages, relative to B7-2, on CNS-infiltrating cells and on splenocytes.

73 to an increased expression of CXCL13 within infiltrating cells and PNAd+ HEV-associated CCL21-produc

74 In the EIU rat eye AqH, both the number of infiltrating cells and protein concentrations of the inf

75 ontrols, with concomitant reduction in graft-infiltrating cells and significantly decreased intragraf

76 DNA fragmentation was found in a number of infiltrating cells and some microglia, whereas, with one

77 Donor-specific CTL activity in graft-infiltrating cells and spleen cell populations of these

78 purpose of this study was to identify early infiltrating cells and to determine whether infiltrating

79 MCP-1 was identified by immunostaining on infiltrating cells and venular (but not arterial) endoth

80 lymphocyte activity of host spleen and graft-infiltrating cells, and circulating complement-dependent

81 Airway hyperreactivity, recruitment of infiltrating cells, and cytokine production were determi

82 T cell proliferation and polarization, renal infiltrating cells, and cytokines in wild-type and NGAL-

83 he CRM genes, significant reduction of graft-infiltrating cells, and extended graft survival.

84 as did the levels of C3 deposition, CD11b(+) infiltrating cells, and fibronectin.

85 ion (proliferating cell nuclear antigen+) of infiltrating cells, and less graft cell apoptosis in art

86 lysis was used to determine the phenotype of infiltrating cells, and light and electron microscopy we

87 pheral blood mononuclear cells (PBMCs), skin-infiltrating cells, and lymphocytes expanded from skin l

88 Mig was detected in glomeruli, tubules, and infiltrating cells, and the expression was significantly

89 itis scores, number of anterior chamber (AC) infiltrating cells, anterior chamber protein concentrati

90 tion of cytotoxic CD8+ T cell dysfunction of infiltrating cells appears to be a beneficial mechanisti

91 the liver, the functional properties of the infiltrating cells are dramatically different in respons

92 Degree of infiltrating cells are graded, and five types are divide

93 endered the IL-10 knockout (KO) mouse, whose infiltrating cells are incapable of IL-10 production, a

94 Therefore, both resident CNS cells and infiltrating cells are necessary for seizure development

95 try revealed that cytokines were produced by infiltrating cells as well as by resident retinal cells.

96 strocytes, other CNS-resident cells, and CNS-infiltrating cells as well as their potential therapeuti

97 -reacted with oligodendrocytes, perivascular infiltrating cells, astrocytes, and neurons in spinal co

98 ad ongoing inflammation with fewer apoptotic infiltrating cells at day 35.

99 We have identified transduced infiltrating cells at the injection site, and the majori

100 cells, but became the great majority of the infiltrating cells at the peak of inflammation on day 7

101 This uncovered differential phenotypes in infiltrating cells based on their intra-tumor location.

102 cytokines which act as chemoattractants for infiltrating cells bearing appropriate receptors (CCR) t

103 oth muscle cell proliferation, and had fewer infiltrating cells but retained endothelialization.

104 mma), and perforin mRNA were produced by the infiltrating cells, but IL-4 mRNA was absent.

105 tion, most likely due to heparanase positive infiltrating cells, but the protein was not upregulated

106 ically in liver sections, analyzed granuloma infiltrating cells by flow cytometry, and measured cytok

107 Cellular deconvolution of graft infiltrating cells by gene expression patterns identifie

108 nent of myocyte injury mediated by allograft-infiltrating cells can be ascribed to CTLs within the in

109 factor mRNA was expressed only in occasional infiltrating cells, cardiac xenografts showed prominent

110 ther Eosinophil or mast cell (Eo/Mc), and no infiltrating cells Cell-).

111 ticking (cells/mm2 endothelial surface), and infiltrating cells (cells/mm2 iris tissue) were evaluate

112 improvements of skin phenotype and number of infiltrating cells, comparable or superior to the effect

113 scle and skin of VCA from group 1 showed few infiltrating cells compared with extensive infiltrates i

114 te allografts from mixed chimeras showed few infiltrating cells compared with extensive infiltrates i

115 re associated with profound changes in tumor-infiltrating cells compared with that in allo-BMT recipi

116 also significantly higher (P<0.01) in these infiltrating cells compared with those in the normal con

117 Overall, AD(+)ACE(10/10) mice had less brain-infiltrating cells, consistent with reduced AD-associate

118 an uveitis and healthy tissues suggests that infiltrating cells could be targeted by inhibitors of th

119 Phenotypic and functional analysis of CNS infiltrating cells during acute infection revealed a pot

120 fic CRM genes and reduce the number of graft-infiltrating cells during AR.

121 med an unbiased examination of diverse islet-infiltrating cells during autoimmune diabetes in the non

122 As have a critical role in the activation of infiltrating cells during intestinal ACR.

123 asL expression in alveolar epithelium and in infiltrating cells during the inflammatory and fibrotic

124 studies, we determined that the predominant infiltrating cells during the innate immune response are

125 requires intercellular communication between infiltrating cells, endothelium, parenchymal cells, and

126 nd the expression of CXCL13 and CCL21 within infiltrating cells, epithelium, and endothelium.

127 The peritoneal infiltrating cells exhibited augmented phagocytosis in S

128 aled that CD11b(+) and MHC class II(+) graft infiltrating cells expressed B7-1 more than B7-2, wherea

129 llowing activation in vitro, whereas retinal infiltrating cells expressed LTB(4)R and C5aR.

130 -based analysis of 304 961 individual marrow-infiltrating cells for 18 of 48 subjects treated on stud

131 is plays a critical role in the clearance of infiltrating cells from eyes with uveitis and leads to t

132 e-cell analysis of intrinsic renal cells and infiltrating cells from patients with LN is a new approa

133 Infiltrating cells from rejected (graft enterectomy for

134 Infiltrating cells from rejected but not quiescent graft

135 that the macrophages remove these apoptotic infiltrating cells from the eye by phagocytosis.

136 f beta cell destruction and disappearance of infiltrating cells from the pancreas, leaving any remain

137 epresents a novel means for protecting tumor-infiltrating cells from tumor-associated oxidative stres

138 ch as ultraviolet, can arrest monocytic skin-infiltrating cells from undergoing dendritic cell precur

139 Graft-infiltrating cells (GIC) recovered from TH1-transfused a

140 The phenotype of graft-infiltrating cells (GIC) showed a dominance of CD8+ cell

141 cyte precursor (HTLp) frequency within graft-infiltrating cells (GIC).

142 Suspensions of graft-infiltrating cells (GICs) and spleen cells were analyzed

143 (but did not abrogate) rejection; CD8 graft-infiltrating cells given adoptively restored normal reje

144 and CD49d (VLA-4) in CCH indicated that the infiltrating cells had some of the characteristics of ac

145 Freshly isolated liver graft-infiltrating cells harvested on days 4 and 7 exhibited s

146 ion of CD80 relative to CD86 on APCs and CNS-infiltrating cells has been shown to correlate with dise

147 lying such process and identification of the infiltrating cells have been the primary objectives in g

148 Heart-infiltrating cells (HICs) were isolated from murine hete

149 Interestingly, despite the paucity of infiltrating cells, HSV-1 clearance from the eyes of -/-

150 r leukocyte chimerism and apoptosis of graft-infiltrating cells, if these end points were similar to

151 ere monitored for diabetes onset, insulitis, infiltrating cells, immune cell function, and beta-cell

152 mitigation of the inflammatory status of the infiltrating cells, improved electrophysiologic visual f

153 s to study TCR-associated functions of graft-infiltrating cells in a preclinical transplantation mode

154 cells were a greater proportion of the early infiltrating cells in accepted vs rejecting grafts.

155 Up to 28% of infiltrating cells in AD skin were identified as allerge

156 CD45(-) neoplastic cells and CD45(+) immune infiltrating cells in all meningiomas.

157 Analysis of lung infiltrating cells in anti-MHC I WT revealed increase in

158 acrophages constituted a major population of infiltrating cells in crescents and contributed signific

159 ecific chemokine receptors were expressed by infiltrating cells in demyelinating MS brain lesions and

160 Analysis of tumor-infiltrating cells in dual PARP-1/PARP-2-deficiency host

161 Furthermore, the lack of tumor-infiltrating cells in FoxM1 mutant tumors appeared relat

162 ate the involvement of CXCR4 mRNA-expressing infiltrating cells in human renal interstitial and vascu

163 megaly; 2) the proportion of Th1 cells among infiltrating cells in inflamed recipient eyes declined r

164 comprises only about 1% of the heterogeneous infiltrating cells in lymph node tissues.

165 afts showed fewer inflammatory foci and CD8+ infiltrating cells in mice injected with hIL-10-TFLs com

166 ir associated receptor expression by retinal infiltrating cells in mouse and human tissues, and in at

167 correlation was found between the number of infiltrating cells in one eye and the IL-6 concentration

168 Cytokine analysis of infiltrating cells in recipient mouse eyes, as well as o

169 ort an important role for DC-SIGN-expressing infiltrating cells in the biology of FL and suggest that

170 mmatory monocytes are the early and dominant infiltrating cells in the CNS during experimental autoim

171 n characterized by increased accumulation of infiltrating cells in the dermis, elevated expression of

172 at model of ACD, we first confirmed that the infiltrating cells in the elicitation phase are indeed C

173 animals associated with a reduced number of infiltrating cells in the ischemic tissue despite the ma

174 While the overall influx of infiltrating cells in the lungs remained largely intact,

175 In the course of the disease, infiltrating cells in the meninges and the ventricles we

176 These findings are consistent with the infiltrating cells in the pGM-CSF-injected muscles being

177 ief overview of key components of the immune infiltrating cells in the tumor microenvironment, review

178 lation in T-cell receptors, macrophages, and infiltrating cells in the vascular grafts, but were inde

179 s in GBM, establishing a rationale to target infiltrating cells in this neoplasm.

180 ominance of Vbeta100(+) T cell subsets among infiltrating cells in two accepted grafts.

181 etected on smooth muscle cells and on tissue infiltrating cells, in close proximity to multinucleated

182 Infiltrating cells included tissue macrophages, with an

183 innate immune signaling between resident and infiltrating cells, including microglia and monocytes, t

184 d iris were virus infected and inflamed, and infiltrating cells increased throughout the period of ob

185 g with precise spatial resolution to profile infiltrating cells inside and outside the QCC niche.

186 We have recently reported that islet-infiltrating cells isolated from NOD mice are enriched f

187 apoptosis is involved in the elimination of infiltrating cells, it plays little or no role in oligod

188 -/TNFR p55-/- mice had a strong reduction in infiltrating cells (knockout 1.6, n = 11; controls 27.3,

189 pulmonary inflammation, as manifest by fewer infiltrating cells, less cytokine/chemokine production,

190 essed by reactive astrocytes, microglia, and infiltrating cells (macrophages and neutrophils).

191 that during WNV infection, CD11b(+)CD45(hi) infiltrating cells (macrophages) are the primary produce

192 production of Th1 cytokines by initial islet-infiltrating cells may cause a greater increase than Th2

193 oss of TCR expression by CD8(+) kidney graft-infiltrating cells may not depend on antigen engagement

194 m, while the procoagulant characteristics of infiltrating cells may reflect a response to tissue inju

195 ation, where inflammation was defined as >14 infiltrating cells/mm(2).

196 Increased caspase activity and apoptosis of infiltrating cells not only occurs during acute cardiac

197 IH, we determined the cytokine production of infiltrating cells obtained from biopsy material by quan

198 pectively) are up-regulated locally in graft-infiltrating cells of AR and tolerant animal allografts.

199 10, and IFN-gamma mRNA was observed in graft-infiltrating cells of both tolerant and AR animals.

200 ellular allograft survival compared to liver-infiltrating cells of untreated rejector mice.

201 Flow cytometry of graft-infiltrating cells on day +12 showed a decreased percent

202 r investigation of the pathologic actions of infiltrating cells on glomerular structure and function.

203 cells per mm (P=0.02) and positive cells per infiltrating cells (P=0.04).

204 %; BC, 3.4%+/-0.57%; and NR, 3.7%+/-0.78% of infiltrating cells; P=0.02).

205 id cell numbers, an increase in CD8(+) liver infiltrating cells, particularly CD8(+) T cells that coe

206 Expression of LFA-1 was also intense on infiltrating cells, particularly in lymphoid aggregates,

207 Graft survival and infiltrating cell phenotype in rejected grafts were comp

208 Fas ligand is expressed on liver-infiltrating cells, pointing to death by fratricide that

209 hin the central nervous system (CNS) include infiltrating cells (polymorphonuclear leukocytes [PMNs],

210 IFN-gamma gene transcripts within the graft-infiltrating cell population and with reductions in circ

211 Neutrophils are the first infiltrating cell population to appear within the CNS du

212 ing cells can be ascribed to CTLs within the infiltrating cell population.

213 otein expression (immunohistochemistry), and infiltrating cell populations (flow cytometry).

214 nated NK cells from the spleen and allograft infiltrating cell populations and decreased early chemok

215 We measured infiltrating cell populations and expression of cytokine

216 ingly, a comparison of circulating and tumor-infiltrating cell populations in lean, and obese mice re

217 ltiple tumor clones and assorted stromal and infiltrating cell populations to pooled genomic data.

218 C subclones and study their association with infiltrating cell populations.

219 infiltrating cells and to determine whether infiltrating cells produce interferon (IFN)gamma.

220 R2 ligand, CCL12, was found to be increasing infiltrating cell proliferation in the heart after AngII

221 AngII infusion and was the result of reduced infiltrating cell proliferation.

222 humor (AqH) was collected, and the number of infiltrating cells, protein concentration, and inflammat

223 The number of infiltrating cells, protein concentration, and levels of

224 Limiting dilution analysis (LDA) of infiltrating cells recovered from rejected allografts af

225 Infiltrating cells recovered from TH1-transfused allogra

226 ular infiltrates, although a small number of infiltrating cells remain around the blood vessels.

227 the blood-brain barrier (BBB) such that most infiltrating cells remain localized to perivascular spac

228 The mucosa and infiltrating cells responded rapidly to the bacterial ch

229 Analyses of splenocytes, PBLs, and graft-infiltrating cells revealed increased alloreactive T cel

230 The immunophenotyping of infiltrating cells revealed that NKG2D was expressed on

231 Macrophages are early islet-infiltrating cells seen in type 1 diabetes (T1D).

232 Fourteen days postgrafting, the sponge infiltrating cells (SIC) were examined for cytotoxic T c

233 s did not reduce the overall number of graft-infiltrating cells significantly but instead resulted in

234 -positive endothelium and underlying SMC and infiltrating cells such as macrophages and leukocytes.

235 Tumor-infiltrating cells, such as macrophages, have been demon

236 directions: it has a proinflammatory role in infiltrating cells that favors tumor development, but it

237 In the kidney, intracellular staining of infiltrating cells that were recovered from kidneys reve

238 X1R and P2X7R are induced in islet allograft-infiltrating cells, that only P2X7R is increasingly expr

239 nifestations, the nature of the inflammatory infiltrating cells, the cytokine response profile, and a

240 Despite the paucity of infiltrating cells, the peak RSV titer in the lung of -/

241 The infiltrating cells then release cytokines, free radicals

242 diation and HCT altered the balance of tumor-infiltrating cells to favor CD8(+) effector memory T cel

243 ur data support a model whereby MB49 induces infiltrating cells to produce IL-10.

244 Chemokines and cytokines organize and direct infiltrating cells to sites of infection, and these mole

245 -K(+)-ATPase) correlates with the ability of infiltrating cells to survive.

246 at eyes had a significantly higher number of infiltrating cells, total protein, and inflammatory cyto

247 eye AqH had a significantly higher number of infiltrating cells, total protein, and inflammatory mark

248 Current imaging modalities based on the infiltrating cell types are briefly discussed.

249 roposed to explain how these multiple tumour-infiltrating cell types block the development of an effe

250 rine signals with other cancer cells and the infiltrating cell types that populate the microenvironme

251 rine signals with other cancer cells and the infiltrating cell types that populate the microenvironme

252 t of the focus score (FS), quantification of infiltrating cell types, immunoglobulin levels, and micr

253 However, FS, infiltrating cell types, immunoglobulin levels, and sali

254 h eosinophils and lymphocytes as predominant infiltrating cell types.

255 lly correlated to histologic findings and to infiltrating cell types.

256 chrome c was present in the cytoplasm of the infiltrating cells undergoing apoptosis.

257 Isolation and characterization of the infiltrating cells using laser capture microdissection a

258 Unexpectedly, the movement of infiltrating cells was closely associated with an infect

259 At days 7 and 24, RANTES production by graft-infiltrating cells was defined with intracellular RANTES

260 Cytotoxic activity of graft-infiltrating cells was determined by 51Cr-release assay.

261 XP3 immunostaining, the number of expressing-infiltrating cells was determined by dividing the region

262 of inflammatory and apoptotic molecules and infiltrating cells was evaluated using immunohistochemis

263 Chemokine expression of the muscle-infiltrating cells was examined by laser capture microdi

264 ignificant reduction in the median number of infiltrating cells was found in TNFR p55-/-/p75-/- mice

265 Maximum expression of tissue factor on rat infiltrating cells was observed 48 hr after transplantat

266 The median number of infiltrating cells was significantly reduced in IL-1RI-/

267 The number of infiltrating cells was significantly reduced in mIL-8Rh(

268 , CD69, and adhesion molecule CD103 by liver-infiltrating cells was suppressed in treated mice with l

269 and functional characteristics of the graft-infiltrating cells were analyzed by in situ and in vitro

270 e were treated with anti-MIG/CXCL9 Ab; graft-infiltrating cells were analyzed for IFN-gamma productio

271 Infiltrating cells were collected from sections of infla

272 Infiltrating cells were collected from the remaining uni

273 the fluid volume and characteristics of the infiltrating cells were determined.

274 tween GIC phenotype and the clinical status, infiltrating cells were examined by flow cytometry, usin

275 me-linked immunosorbent assay, and the graft-infiltrating cells were examined by immunohistochemical

276 Whereas the infiltrating cells were increased in the biopsies with a

277 In Rag-1(-/-) kd/kd, approximately 50% of infiltrating cells were macrophages, and approximately 5

278 The infiltrating cells were mainly human CD3+ T lymphocytes

279 ated from recipient mice revealed that tumor-infiltrating cells were mostly L-selectin- (>95%).

280 es on the skin lesions demonstrated that the infiltrating cells were of the CD3(+)/CD8(+) phenotype.

281 the injection site, and the majority of the infiltrating cells were of the monocyte/macrophage linea

282 y days 19 to 21 after immunization, although infiltrating cells were present, there were only residua

283 The infiltrating cells were primarily neutrophils with a few

284 Although graft-infiltrating cells were reduced approximately 50% in CD4

285 On various days after grafting, graft-infiltrating cells were tested for in vitro cytotoxicity

286 Infiltrating cells were unaffected by the absence of eit

287 beta, and IFN-gamma were highly expressed by infiltrating cells when G-EAT progressed to fibrosis.

288 ets from the CLA-fed animals contained fewer infiltrating cells, which formed limited branching cellu

289 erular parietal cells, vessel walls and some infiltrating cells, which peaked on day 4 together with

290 associated with an altered profile of tumor-infiltrating cells with an increase in natural killer (N

291 Culturing of graft-infiltrating cells with mycobacterial hsp71 and interleu

292 iques confirmed the polyclonal nature of CNS-infiltrating cells, with multiple clones engrafting in b