ライフサイエンスコーパス: influenza virus

1 ytoid dendritic cell function in response to influenza virus.

2 ower than the frequency of pTfh responses to influenza virus.

3 effectively control a modified form of avian influenza virus.

4 ces in ANP32A can restrict the host range of influenza virus.

5 e avian protozoan Eimeria tenella, and avian influenza virus.

6 , similar to respiratory syncytial virus and influenza virus.

7 lly rubbing a paper tissue contaminated with influenza virus.

8 for parainfluenza and from 0.08 to 0.44% for influenza virus.

9 influenza pandemic was initiated by an H2N2 influenza virus.

10 apeutics against pathogenic viruses, such as influenza virus.

11 severity of infection with seasonal or avian influenza virus.

12 creating a need for new drug targets against influenza virus.

13 n effective inhibitor of multiple strains of influenza virus.

14 esult, do not resemble currently circulating influenza viruses.

15 torical seasonal-like and pandemic-like H1N1 influenza viruses.

16 against drifted or, more noticeably, shifted influenza viruses.

17 potent neutralization activity against H1N1 influenza viruses.

18 sitively contributes to the fitness of human influenza viruses.

19 ortant role in cross-species transmission of influenza viruses.

20 B1, PA, NP, and NS genes from other Eurasian influenza viruses.

21 crucial advances for antiviral targeting of influenza viruses.

22 cross-reactive neutralizing antibodies to H2 influenza viruses.

23 dly cross-reactive antibodies to multiple H2 influenza viruses.

24 g our understanding of currently circulating influenza viruses.

25 B1, PA, NP, and NS genes from other Eurasian influenza viruses.

26 response and not protect against multiple H2 influenza viruses.

27 ves from previously circulating human-origin influenza viruses.

28 oadly reactive or universal vaccines against influenza viruses.

29 in reassortment rates across different human influenza viruses.

30 ruses and cocirculating low-pathogenic avian influenza viruses.

31 bitor of the polymerase acid (PA) protein of influenza viruses.

32 btype are endemic and cocirculate with other influenza viruses.

33 s and is the main source of novel pathogenic influenza viruses.

34 ition (HAI) activity against a panel of H1N1 influenza viruses.

35 necessary for the continued surveillance of influenza viruses.

36 es followed by rhinovirus/enterovirus (13%), influenza virus (12%), coronavirus (9%), respiratory syn

37 tions, 1064 (6%) included RT-PCR testing for influenza viruses, 614 (58%) of which were influenza pos

38 polymerase chain reaction (RT-PCR)-confirmed influenza virus A(H1N1)pdm infections and 45 household m

39 xicity and virus-inhibiting activity against influenza virus A/Puerto Rico/8/34 (H1N1) in MDCK cell l

40 orn after 1968 have not been exposed to H2N2 influenza viruses, a future pandemic caused by H2 influe

41 Influenza virus accounted for 7% of ALRI cases, 5% of AL

42 Consequently, identification of avian-origin influenza viruses across mammals appears critical to det

43 However, influenza virus activity in schools is not well-understo

44 t obatoclax or Osu-03012, showed potent anti-influenza virus activity under posttreatment conditions

45 Hemagglutinins (HAs) from human influenza viruses adapt to bind alpha2-6-linked sialosid

46 Rarely, an avian- or swine-origin influenza virus adapts to humans and starts a pandemic.

47 of the human-origin PA gene segment in avian influenza virus (AIV) could overcome barriers to cross-s

48 iagnosis of the highly pathogenic H5N1 avian influenza virus (AIV) is significant for preventing and

49 n result in variable susceptibility of avian influenza viruses (AIVs) carrying resistance-associated

50 H7N9 avian influenza viruses (AIVs) continue to evolve and remain a

51 y found during OS and ZAN selection in avian influenza viruses (AIVs) of the N3 to N9 subtypes for LA

52 and we define the role of metabolism during influenza virus and coronavirus infections.

53 characterizing a novel restriction factor of influenza virus and may ultimately be useful for underst

54 ed changes in response to infection with the influenza virus and on the factors known to increase inf

55 We compared seasonality of sCoVs with influenza virus and respiratory syncytial virus.

56 vide novel insight into interactions between influenza virus and the host innate immune response and

57 ic acids (Sia) are the primary receptors for influenza viruses and are widely displayed on cell surfa

58 c variation has been described for mammalian influenza viruses and for highly pathogenic avian influe

59 d poultry adaptation of H9N2 and other avian influenza viruses and helps us understand the striking m

60 ydrated pore compared with the viroporins of influenza viruses and HIV.

61 many cases, these potentiometers are used by influenza viruses and immune cells to support pathogenes

62 an antiviral agent against a broad range of influenza viruses and paramyxoviruses.IMPORTANCE Influen

63 We identified seasonal human coronaviruses, influenza viruses and rhinoviruses in exhaled breath and

64 tomegalovirus, human immunodeficiency virus, influenza virus, and dengue virus have evolved a multitu

65 technology successfully enriched rhinovirus, influenza virus, and parainfluenza viruses, and maintain

66 (HA), the primary immunogenic antigen of the influenza virus, and the D1 H1-17/H3-14 antibody which h

67 munity in response to antigenic mutations in influenza viruses, and key epidemiological parameters ov

68 genes from concurrently circulating A(H9N2) influenza viruses, and PB2, PB1, PA, NP, and NS genes fr

69 about the role of polyreactivity during anti-influenza virus antibody responses.

70 dy species elicited by previous exposures to influenza virus antigens(4).

71 PORTANCE Robust in vitro culture systems for influenza virus are critically needed.

72 Antigenic property of influenza viruses are determined by both protein sequenc

73 ent of influenza viral infections.IMPORTANCE Influenza viruses are highly contagious pathogens and ar

74 Influenza viruses are highly infectious and are the lead

75 uenza viruses and paramyxoviruses.IMPORTANCE Influenza viruses are important human pathogens that are

76 Influenza viruses are presumed, but not conclusively kno

77 n and influenza virus replication.IMPORTANCE Influenza viruses are responsible for up to 650,000 deat

78 s (Aptamer RCA II) to M2e epitope peptide of influenza virus as a model hapten, and the immune comple

79 inhibitory action against various strains of influenza virus as well as the paramyxoviruses PIV5, HPI

80 se structures therefore reveal mechanisms of influenza virus assembly and disassembly.

81 We estimated the upper bound of influenza virus-associated ALRI deaths based on the numb

82 In 2008, we estimated that 20 million influenza-virus-associated ALRI and 1 million influenza-

83 mated incidence and hospitalisation rates of influenza-virus-associated respiratory infections by sev

84 nfluenza-virus-associated ALRI and 1 million influenza-virus-associated severe ALRI occurred in child

85 cation termination factor 2 (RTF2) restricts influenza virus at the nuclear stage (and perhaps other

86 and classify them as "swine-origin" variant influenza viruses based on phylogenetic analysis and seq

87 Compared with PA-X 195R, H7N9 influenza viruses bearing PA-X 195K showed increased rep

88 thin the human host plays a critical role in influenza virus biology.

89 n hospitalized with ARFI who had testing for influenza viruses by reverse-transcription polymerase ch

90 me viruses, including Epstein-Barr virus and influenza virus can elicit T cell responses against abno

91 e guinea pig whose body is contaminated with influenza virus can transmit the virus through the air t

92 ogy of viruses in this host.IMPORTANCE Avian influenza viruses can jump from wild birds and poultry i

93 -Substituted 2,4-dioxobutanoic acids inhibit influenza virus cap-dependent endonuclease (CEN) activit

94 bserved in H5N1-infected patients.IMPORTANCE Influenza viruses cause upper respiratory tract infectio

95 rus vaccines shows better protection against influenza virus challenge.

96 Although seasonal influenza viruses circulate globally, prevention and tre

97 enza viruses has led to sustained human-like influenza viruses circulating in the U.S. swine populati

98 ine-origin H3N8 and avian-origin H3N2 canine influenza viruses (CIVs) prevalent in dogs are thought t

99 er avidity that more efficiently neutralized influenza virus compared with Xcr1 and DEC-205 targeting

100 Seasonal influenza viruses constantly change through antigenic dr

101 Influenza viruses contain a negative-sense segmented RNA

102 Influenza viruses contain diverse particle subpopulation

103 The results suggest swine influenza viruses containing both a stabilized HA and al

104 As influenza viruses continue to jump species barriers to c

105 Seasonal influenza viruses create a persistent global disease bur

106 These include Lassa pseudovirus, influenza virus, dengue virus type 2, herpes simplex vir

107 ent research on the within-host evolution of influenza virus, dengue virus, and cytomegalovirus.

108 complished by infection with a mouse-adapted influenza virus during pregnancy induced up-regulation o

109 cts and patients with COPD and infected with influenza virus either prior to or after IFN-beta stimul

110 We further show that after the swine-origin influenza virus emerged in humans and caused the 2009 pa

111 Influenza viruses encode a viral RNA-dependent RNA polym

112 hat the X-ORFs of equine H3N8 and avian H3N2 influenza viruses encoded 61 amino acids but were trunca

113 Occasionally, influenza viruses endemic in domestic birds can cause se

114 This supports a model for influenza virus entry where cells restrict or permit mem

115 e discovery of potent and broadly protective influenza virus epitopes could lead to improved vaccines

116 tions for rational vaccine design.IMPORTANCE Influenza viruses escape immunity through continuous ant

117 found that the H5Nx highly pathogenic avian influenza viruses exhibited high virulence in mice and c

118 Influenza virus exploits cellular factors to complete ea

119 Influenza virus exposures in childhood can establish lon

120 New measures of influenza virus fitness could improve vaccine strain sel

121 viruses: respiratory syncytial virus (RSV), influenza virus (Flu), parainfluenza virus (PIV), human

122 Strains of the influenza virus form coherent global populations, yet ex

123 netics were surprisingly similar to those of influenza virus fusion with model membranes of opposite

124 ovide evidence that aberrant RNA products of influenza virus genome replication can trigger retinoic

125 Here, we investigated the effect of influenza virus (H1N1) strains on proteostasis of protei

126 We observed that an influenza virus harboring the R21Q mutation in NS1 resul

127 Influenza viruses harboring treatment-emergent I38F/M/N/

128 Human-to-swine transmission of seasonal influenza viruses has led to sustained human-like influe

129 clades, while reassortment with other avian influenza viruses has led to the emergence of new virus

130 at elicit protective antibodies against H1N1 influenza viruses have been developed.

131 f 2020, over 60 infections of humans by H9N2 influenza viruses have been recorded in countries where

132 Influenza viruses have caused numerous pandemics through

133 Bat influenza viruses have not been tested for their virulen

134 Cleavage of influenza virus hemagglutinin (HA) by host proteases is

135 The activation of influenza virus hemagglutinin (HA) glycoprotein via clea

136 Antigenic drift of influenza virus hemagglutinin (HA) is enabled by facile

137 The conserved, immuno-subdominant influenza virus hemagglutinin (HA) stalk region is a pot

138 nchmarking against known pH sensing sites in influenza virus hemagglutinin and in variants of murine

139 found mAbs targeting conserved neutralizing influenza virus hemagglutinin epitopes were polyreactive

140 To overcome these limitations, we used influenza virus hemagglutinins to engineer a genetically

141 encoded by many enveloped viruses, including influenza viruses, herpes viruses, and coronaviruses.

142 Copper(II) is known to bind in the influenza virus His37 cluster in the homotetrameric M2 p

143 bottleneck between humans infected with the influenza virus; however, the methods used to make these

144 ained circulation of highly pathogenic avian influenza virus (HPAIV) H5N1 A/goose/Guangdong/1996 (Gs/

145 The highly pathogenic avian influenza virus (HPAIV) H5N1 A/goose/Guangdong/1996 line

146 o be associated with highly pathogenic avian influenza virus (HPAIV) H5N1 outbreaks in South-East Asi

147 policies to control highly pathogenic avian influenza virus (HPAIV) infections in chickens.

148 men, and association with protection against influenza virus illness.

149 2, B/Victoria-lineage, or B/Yamagata-lineage influenza viruses.IMPORTANCE Influenza causes widespread

150 on with pandemic-like and seasonal-like H1N1 influenza viruses.IMPORTANCE There is a great need to de

151 ependent type I interferon (IFN) immunity to influenza virus in 659 patients with life-threatening CO

152 nce of simulated sunlight on the survival of influenza virus in aerosols at both 20% and 70% relative

153 r, the impact of sunlight on the survival of influenza virus in aerosols has not been previously quan

154 dentification and quantification of airborne influenza virus in an elementary school, and the results

155 tructure of the HA protein of the avian H7N9 influenza virus in complex with a pan-H7, non-neutralizi

156 dies reveal that H84T is efficacious against influenza virus in vivo, and that the loss of mitogenici

157 Active surveillance of avian influenza viruses in Bangladeshi live poultry markets de

158 of equine-origin H3N8 and avian-origin H3N2 influenza viruses in canine populations are examples of

159 ovides insights into the varying dynamics of influenza viruses in human infection.

160 eutic activity against currently circulating influenza viruses in humans.

161 amatically enhanced the adaptation of animal influenza viruses in mammals.

162 3-adjuvanted versus nonadjuvanted H5N1 avian influenza virus inactivated vaccine.

163 hese IRF5-deficient cells exhibited impaired influenza virus-induced cytokine production and revealed

164 models to investigate the mechanisms driving influenza virus-induced inflammation in humans.

165 r data demonstrate the importance of IRF5 in influenza virus-induced inflammation, suggesting that ge

166 IRF5 could be specifically targeted to treat influenza virus-induced inflammation.

167 e glycan epitope high mannose as a marker of influenza virus-induced pathogenesis and severity of dis

168 D2 and -3 compared to that seen in mock- and influenza virus-infected EREC.

169 ics of the URT microbiomes of uninfected and influenza virus-infected humans and ferrets.

170 col, we describe a methodology for analyzing influenza virus-infected lung in vivo by two-photon imag

171 takes ~30 min and enables the observation of influenza virus-infected lungs for >4 h during the acute

172 ell numbers were decreased in modified avian influenza virus-infected mice.

173 In avian influenza virus-infected patients, the host immune syste

174 Future studies need to investigate whether influenza virus infection affects susceptibility for aor

175 ansmission study, index cases with confirmed influenza virus infection and their household contacts w

176 n, we profile the glycomic host responses to influenza virus infection as a function of disease sever

177 ot formation inside an artery resulting from influenza virus infection as the primary outcome of this

178 udies demonstrated that papaverine inhibited influenza virus infection at a late stage in the virus l

179 Influenza virus infection causes significant morbidity a

180 10 in the therapeutic application against H1 influenza virus infection in humans.

181 otential role in therapeutic treatment of H1 influenza virus infection in humans.IMPORTANCE Respirato

182 The dynamic and resilient microbiome during influenza virus infection in multiple hosts provides a c

183 ZBP1 sensing of the Z-RNA produced during influenza virus infection induces cell death in the form

184 Humoral immune protection against influenza virus infection is mediated largely by antibod

185 To study the contribution of influenza virus infection to cardiovascular thrombotic e

186 logy of Covid-19 from that of equally severe influenza virus infection.

187 ched for pathways related to respiratory and influenza virus infection.

188 show how blood clotting may be connected to influenza virus infection.

189 drives lethal immunopathology during severe influenza virus infection.

190 o associate with lung damage and severity of influenza virus infection.

191 nct to vaccination and drugs in treatment of influenza virus infection.

192 us on their impact on T cell motility during influenza virus infection.

193 ive regulatory signals during modified avian influenza virus infection.

194 e and reveal a new function for PARP1 during influenza virus infection.IMPORTANCE Influenza A virus (

195 ung compartments during primary pneumotropic influenza virus infections and discuss potential similar

196 Natural influenza virus infections and seasonal vaccinations oft

197 NA in an influenza virus vaccine.IMPORTANCE Influenza virus infections are a major source of morbidi

198 Seasonal influenza virus infections cause mild illness in healthy

199 ry-confirmed and antigenically-characterised influenza virus infections from Australia, we investigat

200 In healthy adults, seasonal influenza virus infections result in mild disease.

201 cleared respiratory syncytial virus (RSV) or influenza virus infections, all virus-specific CD8(+) T

202 ination is the most effective way to prevent influenza virus infections.

203 lk antigens first encountered during primary influenza virus infections.

204 se the risk of severe outcomes and death for influenza virus infections.

205 is a known susceptibility factor for severe influenza virus infections.

206 oxavir marboxil, 4, is approved for treating influenza virus infections.

207 swine-origin A(H1N1)pdm09 viruses.IMPORTANCE Influenza virus infects a wide range of hosts, resulting

208 cipants challenged with a 2009 H1N1 pandemic influenza virus inoculum containing an A388V polymorphis

209 Seasonal influenza virus is a common cause of acute lower respira

210 nary rate of IBV.IMPORTANCE The evolution of influenza virus is a significant public health problem a

211 Seasonal influenza virus is associated with high morbidity and mo

212 NA), the second major surface protein on the influenza virus, is emerging as a target of broadly prot

213 s become immunodominant in recent human H3N2 influenza viruses, is also evolutionarily constrained by

214 For swine influenza viruses isolated in 2009-2016, gamma-clade vir

215 Influenza viruses (IV) exploit a variety of signaling pa

216 interferons, their roles in restricting the influenza virus life cycle remain mostly unknown.

217 analysis.IMPORTANCE Low-pathogenicity avian influenza virus (LPAIV) subtypes can reassort with circu

218 ead glycosylation of low-pathogenicity avian influenza virus (LPAIV) subtypes.

219 Low-pathogenic avian influenza viruses (LPAIVs) are genetically highly variab

220 H5 and H7 subtypes of low pathogenic avian influenza viruses (LPAIVs) can mutate to highly pathogen

221 ponses, even while protecting against active influenza virus lung infection.

222 rovides protection against subsequent active influenza virus lung infection.

223 Underneath the viral envelope of influenza virus, matrix protein 1 (M1) forms an oligomer

224 cacious ribonucleoside analogue inhibitor of influenza viruses, MK-4482/EIDD-2801 (refs.

225 A significant effect of papaverine on the influenza virus morphology was observed.

226 For influenza virus, mutational data have shown that the mem

227 imal protection.IMPORTANCE Antibodies to the influenza virus NA can provide protection against influe

228 spite evidence that antibodies targeting the influenza virus neuraminidase (NA) protein can be protec

229 Avian influenza viruses occasionally infect and adapt to mamma

230 in Bangladesh, where highly pathogenic avian influenza viruses of the A(H5N1) subtype are endemic and

231 century, the emergence of H7N9 and H1N1/2009 influenza viruses, originating from animals and causing

232 report demonstrates the efficacy of rewiring influenza virus packaging signals for creating vaccines

233 rrets, a standard component in evaluation of influenza virus pathogenicity, as necropsy findings can

234 chanism of viral genome transcription by the influenza virus polymerase and may be applicable to othe

235 iratory illness (SARI) (2012-2015) underwent influenza virus polymerase chain reaction testing.

236 ANP32 proteins are host factors that act as influenza virus polymerase cofactors.

237 or their ability to support the avian-origin influenza virus polymerase.

238 ested, supports the activity of avian-origin influenza virus polymerases and avian influenza virus re

239 Given the extreme diversity of influenza virus populations, we asked if we could improv

240 ablished in Vietnam to identify the scope of influenza viruses present in live bird markets and the t

241 to antigenically drifted A(H3N2) clade 3C.3a influenza viruses prompted concerns about vaccine effect

242 s interactions of poxvirus, herpesvirus, and influenza virus proteins, we propose a model for viral f

243 Influenza viruses remain a major public health threat.

244 accounting for interspecies transmission of influenza viruses remain unclear.

245 The evolution of influenza viruses remains to be the main obstacle in the

246 levant to human and animal health, including influenza virus, reovirus, HIV-1, human metapneumovirus,

247 Critically, both human and swine influenza viruses replicated in the immortalized cells,

248 origin influenza virus polymerases and avian influenza virus replication.

249 ces our understanding of FluPol function and influenza virus replication.IMPORTANCE Influenza viruses

250 Influenza viruses represent a global public health burde

251 Effective control of emerging influenza viruses requires new broadly protective vaccin

252 d for the treatment of influenza infections, influenza viruses resistant to current FDA antivirals ha

253 s has applied for detection of norovirus and influenza virus, respectively to confirm their applicati

254 ace masks significantly reduced detection of influenza virus RNA in respiratory droplets and coronavi

255 ailable a tool for validating and annotating influenza virus sequences that is used to check submissi

256 e neutralizing antibody (nAb) titers and for influenza virus sequencing, respectively.

257 MG53 knockout mice infected with influenza virus show comparable influenza virus titres t

258 tional 2018-2019 influenza vaccine coverage, influenza virus-specific vaccine effectiveness from the

259 efine the molecular and host determinants of influenza virus spillover from animal to human populatio

260 ns.IMPORTANCE Respiratory diseases caused by influenza viruses still pose a serious concern to global

261 dies do not bind efficiently to the boosting influenza virus strain.

262 of antibodies against A/H1N1, A/H3N2, and B influenza virus strains collected pre- and postvaccinati

263 y of natural compounds against the following influenza virus strains: A/WSN/33 (H1N1), A/Udorn/72 (H3

264 g polymerase chain reaction to determine the influenza virus (sub-)type, viral load, and resistance m

265 nd recognized the HA stem region of multiple influenza virus subtypes.

266 Avian influenza viruses, such as A(H5N1) and A(H7N9), are prim

267 range seen in these viruses.IMPORTANCE Avian influenza viruses, such as H9N2, cause huge economic dam

268 is needed of how antibodies that target the influenza virus surface antigens, hemagglutinin (HA) (in

269 enza viruses and for highly pathogenic avian influenza viruses that circulate in poultry, but much le

270 ntigenic drift and the emergence of pandemic influenza viruses through antigenic shift is unpredictab

271 The genesis of novel influenza viruses through reassortment poses a continuin

272 lear retention of vRNPs and the reduction of influenza virus titers.

273 nfected with influenza virus show comparable influenza virus titres to wild type mice, but display in

274 nt study that IFIT2 is instead repurposed by influenza virus to promote viral gene expression.

275 A-X might be important for the adaptation of influenza viruses to dogs.IMPORTANCE Epidemics of equine

276 The inability of avian influenza viruses to effectively bind human-like sialyla

277 , RTF2, which acts in the nucleus, restricts influenza virus transcription, and contributes to the in

278 RTF2 thus inhibits primary influenza virus transcription, likely acts in the nucleu

279 d child population, a sizeable proportion of influenza virus transmission events are expected to occu

280 t that aerosolized fomites may contribute to influenza virus transmission in animal models of human i

281 ertained, community-based study of household influenza virus transmission set in Managua, Nicaragua.

282 solized fomites." In the guinea pig model of influenza virus transmission, we show that the airborne

283 support antiviral responses and explain how influenza virus uses this same activity to redirect a cl

284 une response that older individuals mount to influenza virus vaccination and infection is critical in

285 While influenza virus vaccination efforts have focused mainly

286 Thus, influenza virus vaccination in humans can elicit a germi

287 he outbreak strain had received the seasonal influenza virus vaccination.

288 coated with a monovalent, split inactivated influenza virus vaccine containing A/Singapore/GP1908/20

289 d as an additional target in next-generation influenza virus vaccine development.We found that antibo

290 gion is a potential universal group-specific influenza virus vaccine epitope.

291 for improving the immunogenicity of NA in an influenza virus vaccine.IMPORTANCE Influenza virus infec

292 bs) derived from B cells induced by numerous influenza virus vaccines and infections, we found mAbs t

293 ase as a potential target of next-generation influenza virus vaccines.

294 olymerase complex plays an important role in influenza virus virulence, and the gene segments of infl

295 Distribution of influenza viruses was described using virologic surveill

296 the PA-X genes of equine H3N8 or avian H3N2 influenza viruses were full-length, with X-ORFs encoding

297 concern persists that these or similar avian influenza viruses will evolve into viruses that can tran

298 Influenza viruses with I38T/F/M substitutions exhibited

299 litate our understanding of the emergence of influenza viruses with increased zoonotic potential.IMPO

300 a weaker pTfh response than the response to influenza virus within the same donors, potentially cont