ライフサイエンスコーパス: ingression

1 myosin II are sufficient to initiate furrow ingression.

2 r chromatid segregation with cleavage furrow ingression.

3 cule PPMP, causes failure of cleavage furrow ingression.

4 o pathways that can initiate cleavage furrow ingression.

5 the furrow cortex are not disassembled after ingression.

6 traction that drives apical constriction and ingression.

7 eads to a failure of apical constriction and ingression.

8 which controls cleavage furrow formation and ingression.

9 own RhoGAP domain also contributes to furrow ingression.

10 nhibitor sFlt-1 locally blocked blood vessel ingression.

11 unction in promoting skeletogenic mesenchyme ingression.

12 ne is expressed only after skeletogenic cell ingression.

13 er, which is active in blastula stage, block ingression.

14 build cortical networks that support furrow ingression.

15 F-actin and membrane integrity during furrow ingression.

16 in, a cellular activity that accompanies PMC ingression.

17 focus on its roles regulating EMT during PMC ingression.

18 that Snail is required in micromeres for PMC ingression.

19 ilament dynamics, thereby controlling furrow ingression.

20 rs including invagination, delamination, and ingression.

21 osin ring contraction during cleavage furrow ingression.

22 cates to the equatorial region before furrow ingression.

23 tion, altering the timing and rate of furrow ingression.

24 esistive forces that slow the rate of furrow ingression.

25 furrow ingressed but failed to complete the ingression.

26 hromosome segregation and cytokinetic furrow ingression.

27 beled PMCs remain within the local region of ingression.

28 eractions with neighboring cells can prevent ingression.

29 ngly, pioneer cells delaminate shortly after ingression.

30 sively stronger cortical contractions during ingression.

31 urrow, and that Cdc42 plays a role in furrow ingression.

32 he marginal region of the blastoderm undergo ingression.

33 anisotropic loss of cell contacts during NB ingression.

34 pomyosin domain, of KLIF in promoting furrow ingression.

35 ane and epithelial adherens junctions during ingression.

36 onverge to ensure successful cleavage furrow ingression.

37 mplex is crucial for normal neural stem cell ingression.

38 inesis regulatory proteins to promote furrow ingression.

39 tion and defects in cytokinesis after furrow ingression.

40 CAP42 and CAP50 in promoting cleavage furrow ingression.

41 m exocytosis and membrane demand from furrow ingression.

42 f microvilli unfolds to fuel cleavage furrow ingression.

43 or midzone MT stabilization following furrow ingression.

44 strate attachment could be regulating furrow ingression.

45 negative mutant increases the rate of furrow ingression.

46 specific midbody region called the secondary ingression.

47 ack to form the PS as a zone of massive cell ingression.

48 ryo is important in supporting timely furrow ingression.

49 generally considered the initiator of furrow ingression.

50 rface curvature allow the furrow to complete ingression.

51 ecome highly stable after furrows have begun ingression [2], indicating that furrow-to-MT communicati

52 and actomyosin contractility to promote cell ingression, a fundamental morphogenetic process observed

53 Thus, asymmetric furrow ingression, a prevalent but previously unexplored featur

54 anterior gradients of convergence speed and ingression along the PS lead to asymmetric exhaustion of

55 Fast ingression also occurs where material turnover is high,

56 Here, we show that Ea/Ep ingression also requires the function of either HMR-1/ca

57 but its role, if any, during cleavage-furrow ingression and abscission is poorly understood.

58 s a lengthy interval between cleavage furrow ingression and abscission, during which the midbody micr

59 a sequential manner to bring about secondary ingression and abscission, respectively.

60 B depletion affects the speed of both furrow ingression and abscission.

61 evation and folding combined with local cell ingression and accretion.

62 late the cortex of the cell to ensure proper ingression and completion of the cleavage furrow.

63 dynacortin and fimbrin similarly slow furrow ingression and contribute to cell mechanics in a myosin-

64 on RhoA signaling enables unilateral furrow ingression and contributes to animal development.

65 a novel role for ARF6 during cleavage furrow ingression and cytokinesis.

66 This mechanistic coupling between ingression and differentiation ensures that the right ce

67 Knockdown of FoxN2/3 inhibits normal PMC ingression and foxN2/3 morphant PMCs do not organize in

68 en morphogenesis begins with mesenchyme cell ingression and gastrulation.

69 tigated the roles of KLIF in cleavage furrow ingression and identified a cohort of KLIF-associated cy

70 Through limited ingression and increased proliferation, NMPs are maintai

71 heless, live imaging identifies simultaneous ingression and intermingling of these two mesodermal lin

72 on of these calcium spikes slowed the furrow ingression and led to frequent lysis of daughter cells.

73 oreover, our observations reveal that furrow ingression and membrane insertion are not strictly linke

74 there is active coordination between furrow ingression and microtubule dynamics.

75 We developed methods to live image furrow ingression and midbody abscission in NSCs within cortica

76 asma membrane at the site of cleavage furrow ingression and midbody formation, and dominant negative

77 re, we calculate the full dynamics of furrow ingression and predict cytokinesis completion above a we

78 is rapid but regulated for cycles of furrow ingression and regression.

79 myosin ring (CAR) constriction with membrane ingression and septum synthesis.

80 uncoupling between a fast ring and membrane ingression and slow septum synthesis, suggesting that cy

81 ry/T transcription factor, reducing mesoderm ingression and slowing down the elongation process.

82 spikes both at the start of cleavage furrow ingression and the end of cell separation.

83 iding of a basement membrane during cellular ingression and tissue formation.

84 inesis became abnormal, generating irregular ingressions and ectopic cleavage sites even when mitosis

85 sociated with abnormal and striking membrane ingressions and protrusions.

86 ch as sister nuclei being kept apart, furrow ingression, and abscission.

87 ll division plane, a halt in cleavage furrow ingression, and an inhibition of cytokinesis completion.

88 structures, contractile ring assembly, ring ingression, and completion.

89 es of microtubule bundle formation, cortical ingression, and F-actin and myosin II accumulation.

90 repression of cadherin expression during PMC ingression, and in part through its role in the endocyto

91 ing trypanosome cells, halts cleavage furrow ingression, and inhibits completion of cytokinesis.

92 ulatory requirements of skeletogenesis after ingression, and may be similarly useful in many other de

93 er mitosis, preparing a soft path for furrow ingression, and releasing G-actin from internal networks

94 ing, cell elongation, polar ruffling, furrow ingression, and separation of daughter cells.

95 tic actomyosin ring contraction and membrane ingression are coupled with deposition of an extracellul

96 interest, ring closure and hence the furrow ingression are nonconcentric (asymmetric) within the div

97 in leading centripetal FCs for their normal ingression, assessed with homozygous shotgun mutant or R

98 During early divisions, furrow ingression asymmetry and midbody inheritance is consiste

99 to examine the molecular mechanisms of cell ingression at a high temporal and spatial resolution, in

100 ghter cell, thereby stalking cleavage furrow ingression at late stages of cytokinesis.

101 nesis phenotype, frequently arresting furrow ingression at the dumbbell shape and/or causing recessio

102 ctin filaments, enabling furrow assembly and ingression before cell division.

103 When furrow ingression begins and internal pressure increases, the s

104 Ingression begins immediately after the onset of epiboly

105 ) and generates force that contributes to PM ingression between daughter cells.

106 receptors suggests that intracellular lipid ingression between receptor helices H6 and H7 may be a g

107 -soft tissue interface may lead to bacterial ingression, breakdown of underlying tissues, and eventua

108 s against EB1 or p150glued suppressed furrow ingression but did not prevent elongation of anaphase as

109 c process before actin assembly and membrane ingression but does not affect the velocity or depth of

110 y of a single micromere do not disperse upon ingression, but instead remain in a closely associated c

111 Either system is sufficient for Ea/Ep ingression, but loss of both together leads to a failure

112 brane trafficking coordinate to drive furrow ingression, but where these membrane stores are derived

113 which active Rab8 populations direct furrow ingression by guiding the targeted delivery of cytoplasm

114 e observed greater average depth of stomatal ingression by S. typhimurium in lettuce under rotation a

115 as a means of potentially reducing stomatal ingression by S. typhimurium under simulated microgravit

116 ral epidermis, consistent with the view that ingression can be regulated by leading-edge cells.

117 ions in apical cross-sectional area and cell ingression characterized by persistent loss of apical ar

118 or expression of skeletogenic genes prior to ingression, complete skeletogenesis also requires the ex

119 mere protein (INCENP) was not found in these ingressions, confirming that INCENP is dispensable for f

120 Ingression constitutes the first invasive cellular activ

121 s microvillar F-actin assembly, while furrow ingression controls microvillar F-actin disassembly.

122 1-GTPase regulator slam and show that furrow ingression controls the rate of microvillar depletion.

123 anced sub-ice shelf melt rates driven by RAW ingression, coupled with surface thinning instigated by

124 During early ingression, Crumbs and its complex partner the RhoGEF Cy

125 es while net cortical tension at the site of ingression decreases throughout constriction and suggest

126 ab39-Klp98A-Rab35 pathway causes deep furrow ingression defects and genomic instability.

127 Sorbitol also rescues endocytic ingression defects of certain endocytic mutants and of c

128 Ea/Ep ingression depends on correct cell fate specification an

129 The process of cell ingression, detachment, and polar aggregation is analogo

130 nce of morphogenetic behaviors that includes ingression, directed migration, and cell-cell fusion.

131 d microvilli are contiguous, we suggest that ingression drives unfolding of the microvilli and incorp

132 Plasma membrane ingression during cytokinesis involves both actin remode

133 ynamics has allowed us to account for furrow ingression during cytokinesis, a model cell-shape-change

134 h prevent mutant NM II from hampering furrow ingression during cytokinesis.

135 cells, resulting in partial cleavage furrow ingression during cytokinesis.

136 , and was further observed to inhibit furrow ingression during cytokinesis.

137 romotes contractile ring assembly and furrow ingression during cytokinesis.

138 ryo undergoes several cycles of rapid furrow ingression during early development that culminate in th

139 , block or dramatically slow cleavage-furrow ingression during early telophase in dividing spermatocy

140 g cleavage furrow stiffness and slows furrow ingression during late cytokinesis as compared to myoII

141 Here, we examine furrow ingression dynamics in the context of the early mouse em

142 sin and apical constriction to ensure robust ingression dynamics.

143 d for daughter cell symmetry than for furrow ingression dynamics.

144 of PMC development, including specification, ingression/EMT, differentiation and skeletogenesis.

145 of the molecular mechanisms regulating cell ingression, epithelial-mesenchymal transition and migrat

146 compartmental behaviors with cortical furrow ingression events are unclear.

147 Thus, FoxN2/3 is necessary for normal ingression, for expression of several skeletal matrix ge

148 Myosin II function is thought to provide the ingression force for cytokinetic furrows, but the role o

149 nger adhesion to the substrate directed less ingression from the bottom of the cell through a pathway

150 mic trigeminal placode begins prior to their ingression (HH11), as early as HH8, and considerably ear

151 intracellular trafficking pathways in furrow ingression; however, the pathways that link compartmenta

152 the cytoskeletal network that drives furrow ingression in Dictyostelium.

153 ons in fws caused failure of cleavage furrow ingression in dividing spermatocytes and failure of cell

154 and MgcRacGAP have been implicated in furrow ingression in mammalian cells, but the signaling upstrea

155 Although furrows can form and initiate ingression in the absence of anillin, furrows cannot for

156 A new analysis of cytokinetic furrow ingression in the Caenorhabditis elegans zygote at high

157 recycling pathway necessary for fast furrow ingression in the Drosophila embryo.

158 Arf GAP Asap is required for cleavage furrow ingression in the early embryo.

159 protein A (RalA) is required for fast furrow ingression in the early fly embryo.

160 biphasic manner, first, after 12 h and until ingression in the skeletogenic descendants of the large

161 imarily due to slower formation of secondary ingressions in WDR5 knockdown cells.

162 rrow assembles; anaphase and cleavage furrow ingression initially appear normal.

163 on microscopy and found that cleavage furrow ingression initiates by contraction of an equatorial act

164 pithelial sheet, leading to delamination and ingression into the mesenchyme where they continue to di

165 f the plasma membrane during cleavage furrow ingression involves the exocytic and endocytic pathways,

166 Unipolar ingression is a common form of gastrulation in the phylu

167 Little is known about how furrow ingression is controlled by KLIF and whether KLIF intera

168 furrows is affected, but the rate of furrow ingression is decreased threefold.

169 Based on these results, we propose that ingression is driven by an actomyosin-based contraction

170 t Schizosaccharomyces pombe, cleavage furrow ingression is driven by polymerization of cell wall fibe

171 Ingression is independent of the Snail family of transcr

172 ophila embryos, to show that cleavage furrow ingression is kinetically coupled to the loss of surface

173 eady, spatially uniform constriction, furrow ingression is modulated by complex contractile oscillati

174 data suggest that an energy barrier to cell ingression is overcome by a combination of relatively fa

175 A model of unipolar ingression is proposed.

176 0.3-9.5 mum(2)/min), the rate for completing ingression is remarkably constant (0.83 cells/min, r(2)

177 Furthermore, cleavage furrow ingression is sensitive to the balance of contractile fo

178 However, ingression is slower in a subset of Kif20b mutant NSCs.

179 How furrow ingression is spatiotemporally regulated and how it is a

180 organize apical-basal polarity contribute to ingression is unknown.

181 ics reminiscent of bottle cell formation and ingression, known mechanisms of germ layer internalisati

182 g cell, generates force to help drive furrow ingression late in cytokinesis.

183 Indeed, during much of ingression, many marginal cells are so loosely arranged

184 Under those conditions, cell ingression may proceed spontaneously.

185 ntial steps of cytokinesis, including furrow ingression, membrane resolution and cell separation in b

186 P16 is not required for PMC specification, ingression, migration, or fusion, but is essential for s

187 tion in morphogenetic processes such as cell ingression, motility, compaction, and cell division.

188 This ingression movement is a classic EMT during which the PM

189 hanges contribute to primary mesenchyme cell ingression movements and to cell rearrangements during a

190 , we present evidence that gastrulation-like ingression movements from the surface continue in the ea

191 is formed as a result of the continuation of ingression movements of gastrulation.

192 In the absence of zygotic transcription, ingression movements proceed normally, but epibolic move

193 We find that polarized furrow ingression occurs at a steady rate and completes in ~15

194 n microscopy at the stage and position where ingression occurs suggests that superficial presumptive

195 Fast local ring ingression occurs where speed oscillations have long per

196 yosin contractile ring that drives the rapid ingression of a deep cleavage furrow.

197 In H. erythrogramma, the differences include ingression of a much higher number of mesenchyme cells,

198 undamental changes in cell morphology is the ingression of a plasma membrane furrow.

199 ulted in the unexpected phenotype of initial ingression of a polar body ring with twice the diameter

200 , providing further evidence of the northern ingression of African biomes into Eurasia and reinforcin

201 at the end of cell division; it proceeds by ingression of an acto-myosin furrow at the equator of th

202 Cytokinesis occurs by the ingression of an actomyosin ring that cleaves a cell int

203 Cell division after mitosis is mediated by ingression of an actomyosin-based contractile ring.

204 ling in the embryonic crosstalk required for ingression of angiogenic vessel sprouts into the develop

205 s suboptimal barrier functions, allowing the ingression of bacteria into the underlying connective ti

206 esenchymal conversion that characterizes the ingression of both primary and secondary mesenchyme cell

207 The ingression of cells in the anterior tailbud only gives r

208 Further, these mutant cells initiate the ingression of cleavage furrows earlier than normal, shor

209 eural gene expression results from continued ingression of CNH-derived cells into the position of the

210 rocess entails a burst of proliferation, the ingression of embryonic epiblast cells at the primitive

211 cale data analyses revealed the asynchronous ingression of epiblast cells at the primitive streak.

212 ud, the lateral part derives from continuous ingression of epiblastic material.

213 chick, we show that isolated EMT events and ingression of individual cells start well before gastrul

214 astrulation acted as a likely switch from an ingression of individual cells to the invagination of th

215 Gastrulation in C. elegans embryos involves ingression of individual cells, but is driven by apical

216 rough a circular blastopore in amphibians to ingression of mesenchymal cells through a primitive stre

217 the epithelial-to-mesenchymal transition and ingression of mesoderm cells through the primitive strea

218 In addition, alpha-bis-PCBM resists the ingression of moisture and passivates voids or pinholes

219 The ingression of neural crest cells from an ectodermal to a

220 avoid the presumptive cornea despite dynamic ingression of neural crest cells.

221 ents of terrestrial ecosystems including the ingression of non-native species(3)(,)(8)(,)(16)(,)(17)

222 urogenesis integrating cell dynamics whereby ingression of pioneer cells instructs neuronal specifica

223 This induction triggers expression of Pax3, ingression of placode cells and their differentiation in

224 Ingression of primary mesenchyme cells is accompanied by

225 This process begins by ingression of prospective primary mesenchyme cells into

226 molecular exchanges (i.e., the egression and ingression of Pt complexes from and into CB[8]) and (2)

227 Brain neurogenesis proceeds by the ingression of single cells from the anterior ectoderm to

228 um of pregastrula stage embryos demonstrates ingression of surface cells into both paraxial and axial

229 s involves formation of a blastocoel and the ingression of surface cells into the blastocoel.

230 tin role during the organization and initial ingression of the cellularization furrow even in the abs

231 Cell-cell contacts also direct ingression of the cleavage furrow in coordination with F

232 allows coordination of AMR contraction with ingression of the cleavage furrow.

233 ntinued translation is required for complete ingression of the cleavage furrow.

234 bly of the contractile ring and triggers the ingression of the cleavage furrow.

235 erence (RNAi) failed cytokinesis without any ingression of the cleavage furrow.

236 he assembly of the contractile ring, and the ingression of the cleavage furrow.

237 ein may not have a role in the formation and ingression of the contractile ring in the cortex.

238 but does not affect the velocity or depth of ingression of the endocytic pit in wild-type cells.

239 We show that ingression of the endodermal precursor cells is regulate

240 Furrow specification occurred normally, but ingression of the furrow was inhibited.

241 lanogaster but do not appear during mesoderm ingression of the midge Chironomus riparius.

242 Ingression of the plasma membrane is an essential part o

243 xocytic events that may be involved in prior ingression of the plasma membrane.

244 mental processes in C. elegans including the ingression of vulval cells as well as germline prolifera

245 on of CED-10/Rac1 and ARX-2/Arp2 facilitates ingression of weak cleavage furrows.

246 overcome turgor, is largely dispensable for ingression; once septation has started, cleavage can con

247 During unilateral furrow ingression, one side of the cytokinetic ring (leading ed

248 3T3 fibroblasts exhibited irregular cortical ingression only when cells started to increase attachmen

249 From ingression onward, however, a dedicated distal module ut

250 hibited SS formation but not cleavage-furrow ingression or the concomitant actomyosin ring constricti

251 and a parameter associated with active cell ingression, our model recapitulates distinct vertebrate

252 ll reservoir is depleted in sync with furrow ingression over 60-70 min.

253 ze mto1Delta and mto2(S338N) cells to furrow ingression phenotypes.

254 tube resulted in supernumerary blood vessel ingression points and disrupted vessel patterning.

255 1 did not produce supernumerary blood vessel ingression points, although the vessels that entered the

256 This is in addition to previously observed ingression processes associated with zipping and apoptos

257 p2, and Cts1, orthologs of components of the Ingression Progression Complex required for septation an

258 During ingression proper, cells leave a single-layered epitheli

259 At ingression, quantitative adhesion assays demonstrated pr

260 We propose that this constant ingression rate contributes to the spatiotemporal regula

261 lls and their neighbors increases the furrow ingression rate, alters topological cell packing followi

262 which correlated with slower cleavage furrow ingression rates.

263 bryos correlates with faster cleavage furrow ingression rates.

264 Finally, ingression relies on the epithelialisation timing contro

265 onsider how various influences contribute to ingression remains elusive.

266 Asymmetric ingression requires Anillin and the septins, which promo

267 tailbud undergo subduction, a novel form of ingression resulting in the restriction of this tailbud

268 cal contractility and drives cleavage furrow ingression, resulting in the formation of a thin interce

269 Ring constriction coupled to plasma-membrane ingression separates the two daughter cells.

270 , and acute inhibition of CYK-1 after furrow ingression slows ring constriction rate, suggesting that

271 ents and thereby negatively regulates furrow ingression specifically on one side of the furrow.

272 ell size is a powerful determinant of furrow ingression speed during reductive cell divisions.

273 e division plane just before cleavage furrow ingression, suggesting that these calcium transients cou

274 Interestingly, although most ingression takes place supramarginally, much occurs clos

275 -biased pattern of supporting cell precursor ingression that occurs in both sexes and results in incr

276 During late ingression, the E3-ubiquitin ligase Neuralized facilitat

277 s initially at the blastoderm margin undergo ingression there, but most recede from the margin and in

278 mporarily inactivated during cleavage-furrow ingression; this inactivation requires the protein Cyk3,

279 s a combination of invagination and unipolar ingression through epithelial to mesenchymal transitions

280 ile simultaneously promoting cleavage-furrow ingression through primary septum formation.

281 the migration of mesoderm cells after their ingression through the primitive streak.

282 d following their movement as they underwent ingression through the primitive streak.

283 , the epiblast, gives rise to new tissues by ingression through the primitive streak.

284 on of axial mesoderm and the continuation of ingression throughout zebrafish tail development suggest

285 n cytoskeleton, resulting in extended furrow ingression times and asymmetrical cell division.

286 We provide evidence that ingression times are determined by genes that control ce

287 indle midpoint are required for initial ring ingression to occur close to the membrane-proximal spind

288 Crumbs endocytosis and recycling allow ingression to occur in a normal timeframe.

289 a multilayered cell mass; we refer to it as ingression-type cell migration.

290 , we have found that, during cleavage furrow ingression, vesicles are internalized from the polar reg

291 endothelial cells to stimulate blood vessel ingression, vessel patterning, and acquisition of mature

292 ous shotgun mutant or RNAi knockdown clones; ingression was influenced non-autonomously by mutant fol

293 onmuscle myosin at their apical surfaces and ingression was slowed.

294 Strontium ingression was tested on coated and uncoated cement past

295 that the CPC is integral for coupling furrow ingression with midzone microtubule stabilization.

296 eny and the exhibition of different forms of ingression within specific tailbud domains.