ライフサイエンスコーパス: inhibin

1 s on cells that are otherwise insensitive to inhibin.

2 unctional interactions with both activin and inhibin.

3 itive model for the antagonism of activin by inhibin.

4 nized by endocrine acting, gonadally derived inhibin.

5 ct and often opposed actions of TGFbetas and inhibins.

6 32] ng/mL, p < 0.001; pro alpha C-containing inhibins 2.2 [0.81] vs 0.71 [0.33] ng/mL, p < 0.001).

7 Molecular-weight forms of inhibin A (32 kDa) and activin A (> 100 kDa) were simila

8 g receptors and is additionally required for inhibin A (InhA) activity.

9 g growth factor-beta (TGF-beta) isoforms and inhibin A (InhA) to enable temporal-spatial patterns of

10 -eclampsia than in control normal pregnancy (inhibin A 3.05 [1.8] vs 0.36 [0.14] ng/mL, p < 0.001; ac

11 nd binding using iodinated recombinant human inhibin A and 125I-labeled recombinant human inhibin A.

12 Inhibin A and activin A are produced by the placenta dur

13 sh the molecular-weight forms of circulating inhibin A and activin A in pre-eclampsia.

14 ysis to assess the molecular-weight forms of inhibin A and activin A.

15 Inhibin A and B are TGFbeta proteins that suppress FSH s

16 Although inhibin A and B binding was 20-fold lower compared with

17 ng of follicle-stimulating hormone (FSH) and inhibin A and B levels.

18 ls of activin A, activin B, alpha-subunit of inhibin A and B proteins, and the antagonists follistati

19 Astrocyte secretion of Inhibin A and downregulation of oligodendrocyte precurso

20 onic gonadotropin, unconjugated estriol, and inhibin A at 15 through 18 weeks of gestation).

21 contrast, infusion of the activin antagonist inhibin A did not influence behavior but blocked the eff

22 Matrilin-2 induces OPC differentiation, and Inhibin A inhibits OPC Matrilin-2 expression and inhibit

23 Inhibin A is induced in reactive astrocytes after stroke

24 sitively correlated with a high activin A to inhibin A ratio.

25 pe III receptor, betaglycan, is required for inhibin A suppression of FSH.

26 Serum concentrations of inhibin A, activin A, and pro alpha C were significantly

27 Biotinylated inhibin A, but not activin A, bound ALK4.

28 ular niche where reactive astrocytes secrete Inhibin A, downregulating Matrilin-2 and blocking myelin

29 ines (granulocyte colony-stimulating factor, inhibin A, Epstein-Barr virus-induced gene 3, interleuki

30 Serum samples were analysed for inhibin A, inhibin B, pro alpha C, and activin A.

31 Higher maternal serum concentrations of inhibin A, pro alpha C, and total activin A in pre-eclam

32 med to measure circulating concentrations of inhibin A, pro alpha C-containing inhibins, and activin

33 ifies several candidate molecules, including Inhibin A-a negative regulator of Matrilin-2.

34 lion and trigeminal ganglion-bound iodinated inhibin A.

35 inhibin A and 125I-labeled recombinant human inhibin A.

36 okeratins 8 and 19, and the absence of alpha-inhibin, a protein characteristically expressed in norma

37 via a distinct site, but are unable to bind inhibin-A.

38 Inhibin abrogates BMP-induced Smad signaling and transcr

39 ta expand our understanding of how endocrine inhibin achieves potent antagonism of local, constitutiv

40 ivins, which are structurally related to the inhibins, act within the pituitary to stimulate FSH prod

41 These findings demonstrate that inhibin, acting through betaglycan, can function as an a

42 that additional components are required for inhibin action.

43 pression profiling has uncovered a defective inhibin-activin signaling pathway in TAFII105-deficient

44 detailed immunohistochemical localization of inhibin/activin alpha-, beta A-, and beta B-subunits thr

45 receptors (alone and in combination) for the inhibin/activin subfamily, we developed a cell-free assa

46 4) mRNAs encoding each of the inhibin/activin subunits are expressed in all major brai

47 ogenase, luteinization hormone receptor, and inhibin/activin subunits.

48 y evidence to suggest that regulation of the inhibin/activin system is essential for early folliculog

49 ive inhibin receptors were isolated using an inhibin affinity column.

50 superfamily members, TGF-beta, activin, and inhibin, all have prominent roles in regulating normal o

51 rum testosterone levels and intra-testicular inhibin alpha and inhibin beta B levels are not altered

52 activation of Fshb inhibitory factors (e.g. inhibin alpha and VGF nerve growth factor-inducible), 2)

53 ca cells may contribute significantly to the inhibin alpha content of FF and peripheral blood.

54 However, exogenous inhibin alpha did not raise androgen production.

55 Targeted disruption of the inhibin alpha gene (Inha(-)(/)(-)) in mice results in an

56 n Inha(-)(/)(-) mice, which demonstrate that inhibin alpha has important consequences upon follicle d

57 We hypothesised that inhibin alpha may modulate the opposing effects of BMP a

58 e findings suggest a positive role of thecal inhibin alpha on androgen production.

59 lls show abundant INHA expression and 'free' inhibin alpha production.

60 Role(s), if any, played by thecal inhibin alpha remain elusive.

61 Absence of inhibin alpha resulted in advanced follicular maturation

62 ction while INSL3 knockdown reduced INHA and inhibin alpha secretion.

63 zed heifers, casting further doubt on thecal inhibin alpha subunit having a significant role in modul

64 o activation of serum glucocorticoid kinase, inhibin alpha, and c-fos genes.

65 Activin stimulates endogenous inhibin alpha- and betaB-subunit mRNA, protein, and prot

66 concentrations differed between control and inhibin alpha-immunized heifers, casting further doubt o

67 The inhibin alpha-subunit mature domain (N terminus) arose r

68 stromal tumors, derived from male and female inhibin alpha-subunit-deficient mice, were also identifi

69 iated with ACC, including SF-1, Melan A, and inhibin alpha.

70 with the p215-234 peptide derived from mouse inhibin-alpha activates CD4(+) T cells and induces exper

71 muscle layers, and lower immunostaining for inhibin-alpha and follistatin.

72 Our inhibin-alpha autoimmune model of POF shows how prematur

73 tive FOXO1 mutant also suppressed cyclin D2, inhibin-alpha, and epiregulin promoter-reporter activiti

74 p-regulation of reporter activities for LHR, inhibin-alpha, and vascular endothelial growth factor is

75 mutant to attenuate induction of cyclin D2, inhibin-alpha, aromatase, SCC, SF-1, and epiregulin.

76 enhanced expression of cyclin D2 as well as inhibin-alpha, aromatase, steroidogenic factor-1 (SF-1),

77 ncluding luteinizing-hormone receptor (LHR), inhibin-alpha, microtubule-associated protein 2D, and th

78 uppressed induction of cyclin D2, aromatase, inhibin-alpha, SF-1, and epiregulin.

79 h1 T cells that stimulate B cells to produce inhibin-alpha-neutralizing Abs directly capable of media

80 Affected mice show high serum levels of inhibin-alpha-neutralizing Abs that prevent inhibin-medi

81 Thus, inhibin-alpha-targeted experimental autoimmune oophoriti

82 Inhibin also binds type II activin receptors and antagon

83 Inhibin also forms crosslinked complexes with both recom

84 Inhibins also bind type II activin receptors but do not

85 Inhibin and activin are best known as gonadal glycoprote

86 Inhibin and activin are members of the transforming grow

87 m pituitary gonadotrope cells, and together, inhibin and activin control the pituitary gonadal axis e

88 The results suggest that central inhibin and activin proteins are produced in the brain w

89 BMP responses, suggesting a broader role for inhibin and betaglycan in restricting and refining a wid

90 Abundant inhibin and few activin binding sites were identified in

91 Mutation of Val614 to Tyr abolishes both inhibin and TGFbeta binding to this domain.

92 the co-receptor actions of betaglycan toward inhibin and TGFbeta will allow the clarification of the

93 We show that the inhibin and TGFbeta-binding residues of this domain over

94 ically enhances the antimigratory effects of inhibin and the ability of inhibin to repress matrix met

95 transforming growth factor beta superfamily, inhibins and activins are a physiologically relevant pai

96 Inhibins and activins are dimeric proteins that are func

97 Inhibins and activins are members of the transforming gr

98 Betaglycan mediates the actions of both inhibins and is broadly expressed.

99 as a cell surface receptor and mediate BMP, inhibin, and TGF-beta signaling suggests a broader role

100 rations of inhibin A, pro alpha C-containing inhibins, and activin A in the serum of women with pre-e

101 eta) superfamily includes TGFbeta, activins, inhibins, and bone morphogenetic proteins (BMPs).

102 The ability of betaglycan to facilitate inhibin antagonism of activin provides a variation on th

103 These betaglycan mutants fail to mediate inhibin antagonism of activin signaling but can present

104 eceptor binding and activity, as well as for inhibin antagonism of activin through its receptors.

105 recise structural aspects that contribute to inhibin antagonism of activin.

106 and ActRIB or ActRIB only, we show that the inhibin antagonistic effects on activin-induced biologic

107 Inhibins are endogenous antagonists of activin signaling

108 The inhibins are gonadal transforming growth factor beta sup

109 Inhibins are ovarian dimeric glycoprotein hormones that

110 anti-Mullerian hormone (AMH; women only) and inhibin B (men only), frequencies of pregnancies, and in

111 kdown or overexpression abrogates or confers inhibin B activity in cells.

112 decrease in antimullerian hormone (AMH) and inhibin B and an increase in FSH with age corresponding

113 lysis was performed to determine the optimal inhibin B and FSH values for identifying patients with a

114 Klotho levels had significantly higher serum Inhibin B and total sperm count than men with the lowest

115 MH), follicle-stimulating hormone (FSH), and inhibin B and urinary level of FSH.

116 ls of follicle-stimulating hormone (FSH) and inhibin B are correlated with sperm concentration, their

117 TGFBR3L binds inhibin B but not other TGFB family ligands.

118 The inhibin B co-receptor was previously unknown.

119 ansmembrane protein, TGFBR3L, is the elusive inhibin B co-receptor.

120 7+/-0.7 nmol per liter], P=0.004), and serum inhibin B concentrations (119+/-52 vs. 60+/-21 pg per mi

121 Inhibin B concentrations in maternal serum were not incr

122 AMH and inhibin B concentrations were generally higher in the Br

123 n the non-azoospermic cancer survivor group, inhibin B concentrations were lower than in controls (me

124 on of bioactive mature activin B, as well as inhibin B dimers, necessary for local follicle-stimulati

125 ocytosis may have had resulted in changes in inhibin B expression.

126 alues, the specificity of the serum level of inhibin B for identifying azoospermic survivors was 45.0

127 sate for the absence of activin B and AB and inhibin B in the process of mammogenesis.

128 evels (LR+ 3.06; 95% CI, 2.06-4.54), and low inhibin B levels (LR+ 2.05; 95% CI, 0.96-4.39).

129 Inhibin B levels (n = 737) were not associated with the

130 jury that caused diminished testosterone and inhibin B levels and oligospermia.

131 ulating hormone, anti-Mullerian hormone, and inhibin B levels correlated significantly with therapy i

132 FSH and inhibin B levels correlated with menstrual status.

133 Although serum inhibin B levels were increased overall in low-dose anim

134 Neither serum inhibin B nor FSH is a suitable surrogate for determinat

135 secretion, indicating a status of pituitary inhibin B resistance.

136 Inhibin B was dichotomized as </= 31 ng/L or more than 3

137 His markedly elevated inhibin B was unable to inhibit FSH secretion, indicatin

138 Gonadal function recovery, AMH, and inhibin B were assessed in the patients of childbearing

139 is was performed and serum levels of FSH and inhibin B were measured in 275 adult male survivors of c

140 Age less than 45 years and inhibin B were significant multivariable baseline predic

141 n type IB receptor, ALK4, and participate in inhibin B's antagonism of activin signaling.

142 e changes were not observed; rather FSH, LH, inhibin B, and anti-Mullerian hormone were temporally al

143 ts of testicular volume, serum testosterone, inhibin B, and gonadotropins in these men with the resul

144 Serum samples were analysed for inhibin A, inhibin B, pro alpha C, and activin A.

145 In contrast, TGFBR3L is inhibin B-specific and selectively expressed in gonadotr

146 inal fluid concentration and increases serum Inhibin-B and anti-Mullerian-hormone levels, but semen q

147 Activins and inhibins belong to the transforming growth factor beta (

148 ligands are formed from two disulfide-linked inhibin beta (Inhbeta) subunit chains.

149 ers (RREs), including an element upstream to inhibin beta A (inhba), a known effector of vertebrate r

150 In this study, we identified inhibin beta A (or Inhba) as a regional paracrine factor

151 evels and intra-testicular inhibin alpha and inhibin beta B levels are not altered in the Six5 mutant

152 In humans, rare Inhibin beta E (INHBE, activin E) loss-of-function varia

153 y and gene ontology (GO) analysis identified inhibin beta-B (Inhbb), an activin subunit and member of

154 The inhibin beta-subunit interacts with the activin type II

155 Inhibin, beta, which is also known as INHBA, encodes a p

156 a calcium/phosphate homeostatic hormone; and inhibin-beta B, a TGF-beta-like factor.

157 Amphiregulin, follistatin, and inhibin-beta-A and epiregulin were activated by an autoc

158 rticularly COX-2, amphiregulin, follistatin, inhibin-beta-A, and CYR61.

159 identified; pro-inhibin betaA and processed inhibin betaA (which dimerizes to activin A) were produc

160 Growing GCT cells expressed high levels of inhibin betaA and nuclear SMAD3, and the proliferation r

161 ules novel to cartilage were identified; pro-inhibin betaA and processed inhibin betaA (which dimeriz

162 e introduced mutations in the context of the inhibin betaA cDNA and assessed the signaling activity o

163 icate that the translational upregulation of inhibin betaA enhances the migration and invasion of cel

164 rotein expression and secreted levels of the inhibin betaA homodimer, activin A.

165 One such transcript inhibin betaA is a member of the TGFbeta superfamily.

166 Here, we show by polysome profiling that inhibin betaA is translationally regulated by TGFbeta vi

167 ckdown of hnRNP E1 relieves silencing of the inhibin betaA transcript, resulting in increased protein

168 male mice in which both alleles encoding the inhibin betaB subunit have been deleted are unable to nu

169 Our results suggest that inhibin betaE is a liver-expressed negative regulator of

170 site is within the betaglycan ZP domain, but inhibin binding is not integral to the ZP motif of other

171 Recently, betaglycan and inhibin binding protein (InhBP/p120, also known as the p

172 eceptor, cause the disruption of activin and inhibin binding to ActRII.

173 h necessary and sufficient for high affinity inhibin binding.

174 betaglycan extracellular domain as the only inhibin-binding region in betaglycan.

175 nhBP/p120 does not play an essential role in inhibin biology.

176 hat BMP signaling might also be sensitive to inhibin blockade.

177 Here we show that inhibin blocks cellular responses to diverse BMP family

178 Activin stimulates whereas inhibin blocks follicle-stimulating hormone biosynthesis

179 e eluted from the column that bind iodinated inhibin but not iodinated activin.

180 InhBP/p120 may not directly bind inhibins but may interact with the activin type IB recep

181 eta receptor, betaglycan, can function as an inhibin co-receptor with ActRII.

182 Inhibin competes with BMPs for type II activin receptors

183 Activins and inhibins compose a heterogeneous subfamily within the tr

184 Inhibin concentrations are high in follicular fluid (FF)

185 gene 1 [IGSF1]) were identified as candidate inhibin coreceptors, shedding light on the molecular bas

186 tability of down-regulated let-7a targets in inhibin-deficient mice (Inha-/-).

187 les, whereas the affinity of the heterodimer inhibin does not.

188 MIS receptor/alpha-inhibin double mutant males developed testicular stromal

189 e identical in phenotype to MIS ligand/alpha-inhibin double mutant males.

190 Inhibins fail to antagonize activin in some tissues and

191 the affinities of activin and its antagonist inhibin for ActRIIb-ECD and found that the affinity of t

192 Betaglycan increases the affinity of inhibins for the activin type IIA (ACVR2) receptor, ther

193 rly during the evolution of the hormone, and inhibin function is decreased by an antibody directed ag

194 GF-beta2 near normal fusion, but activin and inhibin had no effect.

195 both ActRII and ALK4 by each subunit of the inhibin heterodimer, in conjunction with the co-receptor

196 ing a similar beta-subunit, the secretion of inhibin heterodimers (alpha/beta) or activin homodimers

197 type II receptor BMPRII, which does not bind inhibin in the absence of betaglycan.

198 Inhibin, in concert with its co-receptor, betaglycan, ca

199 ); the betaB subunit of the hormone known as inhibin; interleukin-2 enhancer binding factor; an endop

200 Inhibin is a heterodimeric peptide hormone produced in t

201 nd serum tumor markers such as estradiol and inhibin is reasonable.

202 -antagonist relationship between activin and inhibin is unique and critical to integrated reproductiv

203 of gonadotropin-regulating proteins known as inhibins, is a tumor suppressor for testicular stromal c

204 6 mouse ovaries under direction of the alpha-inhibin large promoter.

205 Serum CA-125 and inhibin levels were normal.

206 shedding light on the molecular basis of how inhibins may affect target cells.

207 inhibin-alpha-neutralizing Abs that prevent inhibin-mediated down-regulation of activin-induced pitu

208 Inhibin-null (INH(-/-)) mice develop gonadal tumors and-

209 may modulate the opposing effects of BMP and inhibin on androgen production.

210 line, we analyzed the effects of activin and inhibin on human erythroid differentiation.

211 s not known whether genetic variation in the inhibin pathway also influences susceptibility to testic

212 cleotide polymorphisms (SNP) in genes in the inhibin pathway among participants in the U.S. Serviceme

213 high tumor uptake in PC-3 or PC-3 prostatic inhibin peptide (PIP) tumor-bearing mice.

214 that distinct, though related, activins and inhibins perform unique functions and are not able to co

215 n synergizes with SF-1 to activate the alpha-inhibin promoter through formation of a transcriptional

216 ized with beta-catenin to activate the alpha-inhibin promoter through functional and physical interac

217 pport a cooperative model of binding for the inhibin receptor (ActRII.sTbetaRIII complex) but not for

218 d in this paper indicate that an independent inhibin receptor exists.

219 an)-Fc reconstituted a soluble high affinity inhibin receptor.

220 nt mice, were also identified as a source of inhibin receptor.

221 as been well characterized as a TGF-beta and inhibin receptor.

222 nd signaling pathways, little is known about inhibin receptors or the mechanism by which this molecul

223 embrane proteins were purified, and putative inhibin receptors were isolated using an inhibin affinit

224 Although activins and inhibins regulate follicle-stimulating hormone (FSH) syn

225 Betaglycan can confer inhibin responsiveness on cells that are otherwise insen

226 Finally, betaglycan confers inhibin sensitivity to cell lines that otherwise respond

227 ceptor that regulates TGF-beta, activin, and inhibin signaling.

228 during puberty and pregnancy require activin/inhibin signalling from the stroma.

229 receptor but also require the presence of an inhibin-specific binding component.

230 Numerous tissues were examined for inhibin-specific binding sites, including the developing

231 These data suggest that inhibin-specific membrane-associated proteins (receptors

232 Activins and inhibins, structurally related members of the TGF-beta s

233 We found that the expression of inhibin subunit beta A (inhba) and junB proto-oncogene (

234 he transforming growth factor beta 1 (TGFB1)/inhibin subunit beta A (INHBA) homodimer/Nodal-SMAD2/3 s

235 HSF1 upregulated inhibin subunit beta A and thrombospondin 2, which were

236 n situ hybridization have shown that activin/inhibin subunits alpha, betaA, and betaB; receptors II a

237 mechanism where the regulation of furin and inhibin subunits cooperates in an important positive sho

238 Expression patterns of the inhibin subunits, follistatin, FSTL3, Bambi, Cripto, and

239 Gonadal inhibins suppress FSH synthesis by pituitary gonadotrope

240 Betaglycan also enables inhibin to bind to and compete with BMPs for binding to

241 ratory effects of inhibin and the ability of inhibin to repress matrix metalloproteinase levels in th

242 l significance, we examined ER expression in inhibin transgenic mice that have decreased activin expr

243 eromeric complex of type II, type I, and for inhibin, type III receptors.

244 p) TGF-beta2, rh TGF-beta3, rh activin, or p inhibin was added to the medium in different concentrati

245 Betaglycan binds inhibin with high affinity and enhances binding in cells

246 beta-glycan, binds all 3 TGFbeta ligands and inhibin with high affinity but lacks the serine/threonin