ライフサイエンスコーパス: inhibit

1 l as surfaced other kinases that it potently inhibits.

2 oised to apoptose when survival pathways are inhibited.

3 e and consider how they might be modified or inhibited.

4 ed most frequently where acidic groundwaters inhibited (210)Pb readsorption (felsic-crystalline rocks

5 n, sodium aurothiomalate and aurothioglucose inhibited 48 clinical isolates of N. gonorrhoeae includi

6 explicit role even if the charge transfer is inhibited(8).

7 switch-control kinase inhibitor designed to inhibit a wide range of KIT and PDGFRA mutations.

8 llowing challenge and elicit antibodies that inhibit A. phagocytophilum cellular infection in vitro T

9 allenge groups, but not from control groups, inhibited A. phagocytophilum infection of HL-60 cells.

10 AcrIIA1 also uniquely inhibits a highly diverged Cas9 found in Listeria (simil

11 ation and survival of ABC-DLBCL in vitro and inhibits ABC-DLBCL growth in xenograft models.

12 ble for point-of-need detection of chemicals inhibiting AChE.

13 t remains unclear, although it is thought to inhibit activation of RIPK3 and necroptosis(8).

14 Lymphocyte proliferation was inhibited after 2 h of noradrenaline infusion, and both

15 Butyrate treatment inhibited allergen-induced histamine release and airway

16 Thus, we postulated that inhibiting alpha5 subunit-containing gamma-aminobutyric

17 ased protective proinflammatory response and inhibited amastigote multiplication in infected J774 mac

18 , and activation levels and show that Zn(2+) inhibits AMPARs in an activity-dependent manner, opening

19 uction of the peripheral avascular retina to inhibit angiogenic stimuli to anti-VEGF agents, which in

20 have shown that PDL1-expressing exosomes can inhibit antitumour immune responses.

21 an anti-AQP3 monoclonal antibody (mAb) that inhibited AQP3-facilitated H(2)O(2) and glycerol transpo

22 s bind in the active site and how ethambutol inhibits arabinosyltransferases by binding to the same s

23 We show that aspartic acid inhibits aragonite precipitation from seawater in vitro,

24 We identified a compound, BCH070, that inhibits asexual growth of multiple antimalarial-resista

25 ctions along the genome, translation must be inhibited at a defined point following infection to clea

26 ubset of the antibodies was able to potently inhibit authentic SARS-CoV-2 infection at a concentratio

27 I (CFA/I) fimbriae from Escherichia coli can inhibit autoimmune diseases in murine models by inducing

28 that BBR antagonizes beta-catenin pathway by inhibiting beta-catenin translation and mTOR activity an

29 o inhibition, whereas the bivalent IgG fully inhibits beta-tryptase activity in a hinge-dependent man

30 These compounds can inhibit both mouse and human osteoclast activity.

31 omain protein 1 (EPAS1 encoding HIF-2alpha), inhibited both distinct and overlapping transcriptional

32 ine whereas the wild type strain was already inhibited by 1 mM of the amino acid.

33 Tumor cell migration to LECs was inhibited by blocking CXCL11 whereas recombinant CXCL11

34 Actinins are major F-actin bundlers that are inhibited by Ca(2+) in nonmuscle cells.

35 o an inert polymer scaffold, and binding was inhibited by competing dextran sulfate.

36 Neurons in which GCase was inhibited by conduritol beta-epoxide did not increase th

37 f structural differences with a Bgl3 that is inhibited by glucose.

38 variants display much lower activity and are inhibited by high concentrations of H(2)O(2) upon adsorp

39 %), and increased precipitation (+73.1%) but inhibited by increased drought (-30.4%), N deposition (-

40 driven by the transcription factor E2-2 and inhibited by its repressor Id2.

41 recombinant DSG1; these IgG1 antibodies were inhibited by LJM17, LJM11, and DSG1 in a dose-dependent

42 ndent and saturable and can be competitively inhibited by mannose 6-phosphate, suggesting cation-inde

43 ity is increased by nutrient deprivation and inhibited by overnutrition, inflammation, and hypersecre

44 oduction and HDV replication are effectively inhibited by REP 2139-Ca.

45 atalytic serine protease homologs (SPHs) and inhibited by serpins.

46 lutarate) as an obligate cosubstrate and are inhibited by succinate, fumarate, and 2-hydroxyglutarate

47 lectron pair donors: KPC-2 is preferentially inhibited by sulfonamide and tetrazole-based derivatives

48 This process is inhibited by the cytokine IL-37.

49 hat the Drosophila PLK Polo kinase (Polo) is inhibited by the female meiosis-specific protein Matrimo

50 analogue 2-heptyl-4-hydroxyquinoline-N-oxide inhibited C. thermarum NDH-2 activity, and its potency i

51 Nitrergic agonists inhibited Ca(2+) transients in ICC-SS, and stimulation o

52 tores with cyclopiazonic acid and reduced by inhibiting Ca(2+) influx via Orai channels.

53 ICC-IM responses to EFS were ablated by inhibiting Ca(2+) stores with cyclopiazonic acid and red

54 ecombination with rates of ~0.2 ps(-1), thus inhibiting cage escape and photoproduct formation.

55 s of DHODH in an enzymatic assay, while also inhibiting cancer cell growth and viability and activati

56 immune regulators and eight chemicals which inhibit Candidatus Liberibacter spp. in plant tissues.

57 rom conserving normal pyroptotic function to inhibiting caspase cleavage to disrupting oligomerizatio

58 1 pre-mixed with HMWHA was more effective in inhibiting catabolic events and stimulating anabolic eve

59 3 also has substantially improved ability to inhibit CCL8, CCL7, CCL2, and CCL3 chemotactic function

60 demonstrates that all antileishmanial drugs inhibit CD4 and CD8 T cell proliferation at the doses th

61 e detergent-resistant membrane domain and to inhibit CD40-induced phosphorylation of the kinases Lyn

62 SD genes activate neural differentiation and inhibit cell cycle during the transition, whereas epilep

63 APIO-EE-07 inhibited cell growth and induced apoptosis and also inc

64 functions as a serine/threonine kinase that inhibits cell growth, while the HipB antitoxin neutraliz

65 G-CoA reductase inhibitors that are known to inhibit cellular cholesterol biosynthesis and are clinic

66 We hypothesized that dipyridamole, which inhibits cellular adenosine uptake, could raise the extr

67 , binds Tau with low nanomolar affinity, and inhibits cellular Tau aggregate propagation similarly to

68 The peptide also inhibits cervicovaginal HPV16 pseudovirus infection in a

69 humans and can act as anti-cancer agents to inhibit chemotherapy-resistant tumor growth by consuming

70 SN7-13 does not inhibit coagulation, binds Tau with low nanomolar affini

71 ated degradation of the bonding interface by inhibiting collagenolytic activity.

72 among RhoA and its cytoskeletal effectors to inhibit contractility.

73 regulatory proteins (p21(Cip1) /p27(Kip1) ) inhibit cyclin and cyclin-dependent kinase (CDK) complex

74 The antimalarial agents artemisinins inhibit cytomegalovirus (CMV) in vitro and in vivo, but

75 the GNP-glycans can potently and completely inhibit DC-SIGN-mediated augmentation of Ebola virus gly

76 in MCF10A H-RAS(V12) breast cancer cells by inhibiting de novo proline biosynthesis and impairing sp

77 First, we demonstrate 5-InsP(7) inhibits decapping by recombinant NUDT3 (Nudix [nucleosi

78 Furthermore, we show that GacB is inhibited directly by cyclic di-GMP, which provides evid

79 K2 that blocked IL-23 signaling in vitro and inhibited disease progression in animal models of SpA.

80 eins belong to the Dispanin/CD225 family and inhibit diverse virus infections.

81 otentiating radiotherapy and chemotherapy by inhibiting DNA damage repair is proposed as a therapeuti

82 We also assessed the ability of cocaine to inhibit dopamine uptake in the nucleus accumbens core us

83 obic polymer that was extremely effective at inhibiting drug crystallization, and a less effective, b

84 is potentiated when evoked during threat and inhibited during safety.

85 Niraparib and rucaparib inhibit DYRK1s, CDK16 and PIM3 at clinically achievable,

86 The most potent derivatives, 22 and 30, inhibit early steps of the replicative cycles of HIV-1 a

87 Friend virus (FV) model, Tregs are known to inhibit effector CD8+ T-cell responses and contribute to

88 The addition of latrunculin A to acutely inhibit endocytosis shows that rcy1Delta and snx4Delta s

89 molecules have been classically developed to inhibit enzyme activity; however, new classes of small m

90 enhanced eosinophil spreading on VCAM-1 but inhibited eotaxin-1 (CCL11)-mediated eosinophil migratio

91 or C-I suppressed colonosphere formation and inhibited expression of CD44, DCLK1 and LGR5.

92 sociated with improved task performance, and inhibiting eye movements in humans impaired navigation p

93 In contrast, stronger L6 drive inhibited firing and suppressed overall sensory function

94 about how leptin acts in the NTS neurons to inhibit food intake.

95 reveal a neural circuit from VMH to PVT that inhibits food intake.

96 Furthermore, inhibiting force generation in cancer cells would increa

97 behaviour and the timing of reproduction can inhibit genetic exchange between closely related species

98 the same tissues, many of these channels can inhibit GPCR desensitization.

99 Pure L. murinus conditioned culture medium inhibited growth and reduced the extension of pneumococc

100 we then found that EC-specific YY1 ablation inhibited growth factor-induced angiogenesis.

101 nts with immunodeficient mice, mAb treatment inhibited growth of mutant TP53, WT PTEN LN-229 tumors,

102 Addition of excess mDAP inhibited growth of this strain, but overexpression of d

103 Depletion of Gln4p inhibited growth, and induced a GCN4 amino acid starvati

104 of beneficial bacteria while simultaneously inhibiting growth of opportunistic ones.

105 Indeed, survival of autophagy-inhibited HCMV-infected monocytes was rescued when MLKL

106 but whether bacterial cell wall constituents inhibit HCO(3) transport in the outer medullary collecti

107 glacial and landslide damming in this region inhibited headward propagation of river incision into th

108 a lethal dose of venomous PLA2, L&K-NPs also inhibit hemolysis and confer a significant survival bene

109 The drug JQ1, which inhibits histone acetyl-lysine reader bromodomains, has

110 o identify HIV-1-suppressing agents that can inhibit HIV-1 reactivation and reduce HIV-1-induced immu

111 nfected recipient cells while simultaneously inhibiting HIV transcription.

112 We show that SP rapidly inhibits HIV-1 transcription by reducing RNAPII recruitm

113 echanotransductive signaling, and completely inhibits HO.

114 nd inhibits PALB2-BRCA2 interaction, thereby inhibiting HR repair.

115 ly bound to native and venomous agent X (VX)-inhibited human AChE, here we created seven uncharged ac

116 the as-prepared Cu surface with Cu(0) which inhibits hydrocarbon formation.

117 ar whether HY5 uses additional mechanisms to inhibit hypocotyl elongation.

118 During studies with the hydroxylase, factor inhibiting hypoxia-inducible factor 1 (FIH-1), we observ

119 plays a key role in the PPP5C-FKBP51 axis to inhibit I(SOC) and protect the endothelial barrier again

120 nous Src tyrosine kinase that constitutively inhibits I(Kv1.5) Disrupting the Src-binding motif of Kv

121 mAbs displayed broad and potent capacity to inhibit IBV NA enzymatic activity, neutralize the virus

122 MG53 inhibits IFNbeta induction in an RyR-dependent manner.

123 , which has been used as a research tool for inhibiting immune cell trafficking.

124 and the mechanisms by which inflammation may inhibit immunity.

125 y ill patients, we showed that mitophagy was inhibited in blood monocytes of patients with sepsis as

126 including nonsense-mediated decay (NMD), are inhibited in c9ALS/FTD brains and in cultured cells expr

127 h yield growth of carbon nanotubes (CNTs) is inhibited in electrolytes containing over 50 wt% of sodi

128 enched into a stable glassy state, otherwise inhibited in the analogous racemic MHP.

129 re, we investigated the ability of soy PG to inhibit inflammatory mediator expression in response to

130 tory T cell-inducing molecule retinoic acid, inhibiting inflammatory cytokine production, and making

131 nce of DMNDC, suggesting that DMNDC does not inhibit insulin aggregation.

132 Inhibiting IRE1alpha blocked stellate cell activation, w

133 which led to STING carbonylation at C88 and inhibited its trafficking from the endoplasmic reticulum

134 rget of anticancer and anti-obesity drugs by inhibiting its DNA-binding activities.

135 n through regulation of its promoters and by inhibiting its presentation through interaction with the

136 TTR binds Abeta, alters its aggregation, and inhibits its toxicity both in vitro and in vivo In this

137 f the O-fucose site on EGF12 allowed LFNG to inhibit JAG1-NOTCH2 activation, and O-fucosylation on EG

138 TRADD modulates cellular homeostasis by inhibiting K63-linked ubiquitination of beclin 1 mediate

139 reas phosphorylation at the other sites only inhibits Katanin ATPase activity stimulated by MTs.

140 Treatment of HFD-fed mice with verteporfin inhibited KC activation, reduced liver inflammation, and

141 ore the therapeutic potential of transiently inhibiting LDH during adoptive T cell-based immunotherap

142 LIN28B or a LIN28B mutant that is unable to inhibit let-7 processing increases the penetrance of MYC

143 arency results from structural partial order inhibiting light scattering, while preserving mechanical

144 Understanding how PLA2 inhibits lipid oxidation promoted by hemoglobin (Hb) is

145 Inhibiting LOX reduces collagen cross-linking and fibron

146 strategy to decrease sputum eosinophils and inhibit lung mast cells in asthma.

147 l-OCH3 decreased tumor growth and weight and inhibited lung metastasis.

148 atal testosterone and low prenatal oestrogen inhibits lung development and may predispose individuals

149 Six of these compounds inhibited M(pro), showing half-maximal inhibitory concen

150 lec-8 antibody that depletes eosinophils and inhibits mast cells and that has shown potential in anim

151 Therapeutically inhibiting matrix metalloproteases (MMPs) suppressed bot

152 ng the series, FCW34 and FCW66 were shown to inhibit MDA-MB-231 cell migration as effectively as ST3G

153 SMI#9 treatment inhibited melanoma cell proliferation but not normal mel

154 ition and endothelin receptor antagonization inhibited mesenchymal lineage conversion in TGFbeta1-exp

155 stasis suppressor, a class of proteins which inhibits metastatic spread of cancer cells without impac

156 In gene expression studies, SHP inhibited miR-210 expression by repressing a transcripti

157 ed genetic manipulations and pharmacology to inhibit MNK-eIF4E activity in animals with spared nerve

158 omas on MNT for survival suggests that drugs inhibiting MNT could significantly boost therapy of MYC-

159 deeper discrimination architectures without inhibiting model convergence.

160 ral activity, were tested for the ability to inhibit multiple diverse enveloped viruses.

161 signaling to phosphoinositide metabolism and inhibits MyD88-directed signal transduction.

162 l-regulated kinase pathway inhibition and to inhibit myeloid-derived suppressor cells in various mela

163 We now demonstrate that inhibiting NAA synthesis by intracisternal administratio

164 Both also effectively inhibited NAPE-PLD activity in cultured HEK293 cells.

165 endogenous bile acid lithocholic acid (LCA) inhibits NAPE-PLD activity (with an IC(50) of 68 mum), b

166 y and sufficient both to degrade MLKL and to inhibit necroptosis.

167 , one of the VTA Sst neuron subtypes locally inhibited neighboring dopamine neurons.

168 e extracellular signals that nonsynaptically inhibited neighboring PCs.

169 the prefrontal region during REM sleep, and inhibited neural activation in the untrained region in e

170 ed synaptic plasticity, which was blocked by inhibiting neural lactate uptake.

171 ts primary role is to protect lung tissue by inhibiting neutrophil elastase.

172 se compounds reduces neutrophil velocity and inhibits neutrophil recruitment in response to inflammat

173 5 and dominant-negative mutant IkappaBalphaM inhibited NF-kappaB activity and increased P-p53, p53, a

174 viral activity, we show that PG specifically inhibits NF-kappaB and Akt signaling pathways and promot

175 These compounds inhibited notch signaling by reducing the expression of

176 r (DAPT), a gamma-secretase inhibitor, which inhibits Notch signaling.

177 of different classes and either stimulate or inhibit nucleotide exchange depending on the G-protein s

178 e acceleration observed for Galpha(i), DAPLE inhibited nucleotide exchange on Galpha(s) and Galpha(q)

179 pients, producing metabolites that no longer inhibit OATP2B1 transport.

180 All viruses require strategies to inhibit or evade the immune pathways of cells that they

181 The receptors inhibit or stimulate CheA kinase activity depending on t

182 Preadministration of nonradioactive biotin inhibited organ uptake and increased excretion.

183 tiple protein kinases that either promote or inhibit origin activation, which is important for genome

184 lished ccRCC cell proliferation in vitro and inhibited orthotopic tumor growth in vivo.

185 We show that tatM2NX inhibits over 90% of TRPM2 channel currents at concentra

186 Results indicated that EVs markedly inhibited oxidation reaction, total volatile base nitrog

187 mall molecule inhibitor, pifithrin-alpha, to inhibit p53 signaling, and nutlin-3a, a small molecule i

188 nistically, CXorf67 interacts with PALB2 and inhibits PALB2-BRCA2 interaction, thereby inhibiting HR

189 phonylureas, widely prescribed for diabetes, inhibit pancreatic ATP-sensitive K(+) (K(ATP) ) channels

190 ngiogenic stimuli to anti-VEGF agents, which inhibit pathologic angiogenesis but also extend normal i

191 targeting PKC with pharmacological tools to inhibit pathologic fibrosis has not been fully evaluated

192 hat PCSK9-LDL association in the circulation inhibits PCSK9 activity.

193 the more than 700 extracts, one consistently inhibited Ph. infestans cyst germination.

194 To examine the ability of each antibody to inhibit phagocytosis of platelets, the antibodies were u

195 concentrations of S1P in vitro In addition, inhibiting phospholipase A2 (PLA2) or lipoxygenase (Lox)

196 phosphorylation in one protomer of the dimer inhibits phosphorylation in the second protomer, leading

197 (ZmPTPN) promoted, while knockdown of ZmPTPN inhibited plant drought tolerance, indicating conserved

198 mosquito vectors of the disease, ivermectin inhibits Plasmodium falciparum sporogonic and blood stag

199 XCR5IFN-gammaCD8 T-cell subset significantly inhibits posttransplant alloantibody production in a mur

200 er to show that while depletion of DeltaNp63 inhibits primary mammary adenocarcinoma development, osc

201 s in this procedure, saccades and blinks are inhibited prior to predictable relative to unpredictable

202 Early evidence suggested that actinonin inhibited prokaryote-like post-translational modificatio

203 acid mini-protein is cell permeable and can inhibit proliferation of Myc-dependent cell lines.

204 or shRNA-mediated functional ABCB5 blockade inhibited proliferation and survival of GBM cells and se

205 bsent in the dentate gyrus, which was due to inhibited proliferation of neural stem cells (NSCs).

206 Finally, 45 inhibited proliferation of two cancer cell lines that ar

207 Loss of SMAD7 in beta cells inhibited proliferation, and SMAD7 overexpression enhanc

208 The REV-ERB agonist SR9009 inhibited promoter activity of diverse HIV-subtypes and

209 valonate biosynthesis inhibitor, selectively inhibited protein prenylation and induced apoptosis in M

210 unlikely that mHTT interacts with TIM23 and inhibits protein import in intact mitochondria.

211 Plant cell wall-associated polygalacturonase-inhibiting proteins (PGIPs) are widely distributed in th

212 The formation of ARM inhibits PSD-LTM but the underlying molecular processes

213 d linker, the first molecule to successfully inhibit PTP activity through degradation has been develo

214 ethionine, lipid, and purine metabolism, and inhibited quiescence, which explains the life span short

215 ric oxide synthase (iNOS), which we found to inhibit R. parkeri.

216 st of the prostaglandin D2 receptor that may inhibit recruitment and activation of airway eosinophils

217 specifically projecting to VLO significantly inhibited respiratory responses evoked by inhalation of

218 On the neural level, both OXT and LZP inhibited responses to fearful faces vs. neutral faces w

219 tion and recruitment of Myo9b, which locally inhibits Rho activity to enhance directional cell migrat

220 ration enhancing and the other configuration inhibiting RNA unwinding compared with the unconstrained

221 complex WP5 G quenches the fluorescence and inhibits ROS generation of G.

222 tion, we showed that this miRNA specifically inhibits Salmonella infection via modulation of endolyso

223 ation of potential therapies and vaccines to inhibit SARS-CoV-2 infection and ameliorate disease is t

224 d Azithromycin were confirmed to effectively inhibit SARS-CoV-2 replication in vitro with EC50 values

225 this in vivo study confirms that Scia highly inhibits SCD1 expression and activity.

226 The inability of mycolactone-inhibited Sec61 to effectively transport substrate prote

227 neered single-chain variable fragment (scFv) inhibited seeding by IL15-induced tau oligomers and path

228 ween pain catastrophizing and the ability to inhibit selective attention to pain-related faces (atten

229 ecursor UDP-glucuronic acid is sufficient to inhibit several mesenchymal-like properties including ce

230 The most potent azaindole 45 inhibits SHP2 with an IC(50) = 0.031 muM in an enzymatic

231 marily the acetylcholine receptor (AChR) and inhibit signaling at the neuromuscular junction.

232 iamycin-resistant BC cells, while adriamycin inhibited SM-164-resistant BC cell growth, similar to pa

233 l parabrachial nucleus (LPBN(Htr2c) neurons) inhibit sodium appetite.

234 To identify Acrs capable of inhibiting Staphylococcus aureus Cas9 (SauCas9), an alte

235 MS3-6 expression strongly inhibits STAT3-dependent transcriptional activation and

236 ELMO1 phosphorylation, destabilise the auto-inhibited state to promote an active GEF.

237 This inhibited STING polymerization and activation of downstr

238 h its receptor programmed cell death 1 (PD1) inhibits T cell responses, and blockade of this interact

239 2AA accumulation inhibits target enzymes with a detrimental impact on fit

240 Additionally, integrin blockade inhibited tECM-driven TGFBR2 expression, while inhibitin

241 hibited tECM-driven TGFBR2 expression, while inhibiting TGF-beta signaling decreased tECM-mediated ex

242 urface presentation of HLA proteins known to inhibit the activation of an immune cell known as a natu

243 reatment of acute myelogenous leukemia (AML) inhibit the activity of the mammalian topoisomerase II (

244 The ability of RGFP966 to inhibit the AIM2 inflammasome was confirmed in an experi

245 NDNF+ cells also inhibit the apical dendrites of L5 pyramidal tract (PT)

246 n intermediate insulation layers are used to inhibit the charge transfer(5,6) or when off-resonance e

247 That is, early life adversity may inhibit the formation of supportive social ties, and wea

248 -quinidine conjugate retained its ability to inhibit the function of P-gp (log IC(50) of 4.20 nM for

249 degradation is a very effective approach to inhibit the function of SHP2.

250 Furthermore, both VEGF and NRP-1 knockdown inhibit the growth of patient-derived GBM xenografts in

251 present study shows that TA and EGCG do not inhibit the phospholipid-scrambling or ion conduction ac

252 ten use elongation inhibitors to purportedly inhibit the release of puromycin-labeled nascent peptide

253 (NRP-1) attenuate cancer stem cell markers, inhibit the tumor-initiating cell's neurosphere-forming

254 ), we showed that the efflux agonist did not inhibit the uptake of extracellular leucine but instead

255 nd genetic knockdown of SREBP1 significantly inhibited the cell proliferation of mutant KRAS-expressi

256 RSV significantly inhibited the development of periodontitis and vascular

257 rther analyses revealed that beta-rubromycin inhibited the germination of cysts and oospores in Pythi

258 interfering with the mTORC1/4E-BP/eIF4E axis inhibited the growth potential endowed by accumulation o

259 blockage of nSMase in monocytes/macrophages inhibited the secretion of inflammatory mediators IL-1be

260 mmune lymphocytes halted LVS replication and inhibited the spread of LVS infection between macrophage

261 In liquid assay system, both GO and MGO inhibited the target bacteria at concentrations signific

262 lf, here we have examined the feasibility of inhibiting the Hsp70 co-chaperone DNAJA1 as a novel anti

263 known to downregulate cytokine signaling by inhibiting the JAK-STAT pathway.

264 indle by clathrin stabilizes microtubules by inhibiting the microtubule depolymerase MCAK.

265 surface iridium sites, whilst significantly inhibiting the surface cation corrosion during electroca

266 f TPPP1 by EBV-miRNA-BART12, which, in turn, inhibits the acetylation of alpha-tubulin, and promotes

267 cal oligomer concentrations, the interaction inhibits the autocatalytic proliferation of amyloid fibr

268 ts the activation by PIP(2); and cholesterol inhibits the channel.

269 Furthermore, hC4Nb8 inhibits the classical pathway-mediated immune complex d

270 type I interferon signaling pathway Tyk2 and inhibits the expression of genes induced by type I inter

271 TSPN6 also inhibits the shedding of the SDC4 ectodomain, mimicking

272 r response machinery but also simultaneously inhibits the STAT3-induced cancer cell proliferation, de

273 ytes provide negative feedback to PDLSCs and inhibit their activities through sclerostin.

274 transformation of LMP1-expressing B cells by inhibiting their differentiation to plasma cells.

275 elf-renewal of stem and progenitor cells and inhibiting their differentiation.

276 orced overexpression of GILZ in mature Tregs inhibits their suppressive function.

277 Furthermore, inhibiting these neurons impairs punishment-based learni

278 and germination and describes strategies for inhibiting these processes to prevent C. difficile infec

279 entified 21 novel compounds that selectively inhibit this enzyme.

280 In hPPECs, TM2 inhibited thrombin-induced ERK1/2 phosphorylation and ac

281 h-and-capture." Inhibition of Arp2/3 complex inhibits TMT assembly by both mechanisms.

282 as been proposed that macroautophagy must be inhibited to maintain genome integrity.

283 any bacterial small RNAs (sRNAs) efficiently inhibit translation of target mRNAs by forming a duplex

284 were attenuated by TRPA1 inhibition, whereas inhibiting TRPV3 exacerbated ERS and cytotoxicity.

285 microvascular endothelial cell interactions, inhibited tube stability, and disrupted endothelial cell

286 ciation constant (K(d)) 0.4 +/- 0.1 muM] and inhibits tubulin polymerization in vitro; 4) had no effe

287 s ability to downregulate c-MYC and directly inhibit tumor cell proliferation, NHWD-870 blocks the pr

288 AF3IP2 is more effective; targeting TRAF3IP2 inhibited tumor formation, regressed preformed tumors, a

289 hat while silencing Rab27a and TRAF3IP2 each inhibited tumor growth and metastasis, silencing TRAF3IP

290 care should include bone-targeted agents to inhibit tumour-associated osteolysis and prevent skeleta

291 Moreover, the capability of caftaric acid to inhibit tyrosinase activity was evaluated by spectrophot

292 lexes with the E3 ligases RNF43 and ZNRF3 to inhibit ubiquitylation of Wnt receptors.

293 stric fluid and their enzymatic activity was inhibited upon heat treatment.

294 However, SP-2509 does inhibit viral DNA replication, late gene expression, and

295 and Drug Administration-approved drugs that inhibit viral entry, endocytosis, genome assembly, trans

296 a live challenge with RSV infection but was inhibited when BMDCs were treated with GSK J4 prior to s

297 Class 1 mutations (8 of 27) inhibit while class 2 mutations (5 of 27) enhance PFC ne

298 These results suggest that FL3 inhibits Wnt/beta-catenin signaling via PHB1-dependent a

299 nd, LQZ-7, and when given orally effectively inhibits xenograft tumor growth and induces survivin los

300 Overall, these data show that Rh-PPO inhibits xenograft tumor growth, supporting the strategy