ライフサイエンスコーパス: inhibiting

1 yrins through substrate reduction therapy by inhibiting 5-aminolevulinate synthase 2 (ALAS2), the fir

2 MICs inhibiting 50 and 90% of organisms (MIC(50) and MIC(90),

3 adly affect responses to more than 200 drugs inhibiting a broad spectrum of cancer-relevant targets.

4 d that miR-671-5p reduces LUSC metastasis by inhibiting a circular RNA (circRNA), CDR1as.

5 o drive the differentiation of PC12 cells by inhibiting a nuclease that promotes RNA-induced silencin

6 hreat-reward decision-making by retrogradely inhibiting a pair of premotor command interneurons, AVA,

7 onclusion that SPT-enol acts on nematodes by inhibiting ACC.

8 ble for point-of-need detection of chemicals inhibiting AChE.

9 Moreover, differing levels of inhibiting/activating activity produce contrasting patte

10 lack tea and phytic acid exerted the highest inhibiting activities, similar to the already known inhi

11 K-4 (IC(50) = 20 nm), with only minimal TAK1-inhibiting activity (IC(50) = 0.5 mum).

12 udied regarding their cytotoxicity and virus-inhibiting activity against influenza virus A/Puerto Ric

13 ing antibodies that have no hemagglutination-inhibiting activity and are less potent than strain-spec

14 In vitro growth-inhibiting activity of abietadien-19-ol and syn-pimara-7

15 Using pHLARE we show decreased pHlys with inhibiting activity of the mammalian target of rapamycin

16 a sequence feature that promotes LLPS while inhibiting aggregation.

17 ies of immune resistance that are reduced by inhibiting Akt-activated beta-catenin.

18 Inhibiting Aldh3a2 provides a therapeutic opportunity an

19 Inhibiting alpha2delta-1 with gabapentin or disrupting t

20 Thus, we postulated that inhibiting alpha5 subunit-containing gamma-aminobutyric

21 he 4-glucosylcatechol dibenzoate, the latter inhibiting also butyrylcholinesterase and beta-glucosida

22 oints following MO treatment were reduced by inhibiting AMPA and NMDA receptors in the spinal cord.

23 Importantly, therapy inhibiting (anti-IL-6) or mimicking (IGF-1) the cardiac

24 There was no effect of inhibiting any of these pathways on reward sensitivity,

25 hich increases PKM2 catalytic activity while inhibiting any PKM2 signalling functions.

26 lternate ORF in the mitochondrial genome and inhibiting apoptosis through interactions with the pro-a

27 also focused on the therapeutic potential of inhibiting asprosin for treatment of obesity and type 2

28 rmediate filament protein, vimentin, thereby inhibiting assembly of vimentin filaments.

29 ally, chronic T1D leads to glucolipotoxicity inhibiting autolysosome efflux, which in turn intensifie

30 go-A has been widely studied for its role in inhibiting axonal regeneration following injury to the c

31 nts ISO-induced apoptosis of kidney cells by inhibiting Bax protein upregulation and caspase-3 activa

32 Galectins have been implicated in inhibiting BCR signaling in mature B cells but promoting

33 ed chemotherapy and radiotherapy response by inhibiting BCSC self-renewal and associated pluripotency

34 We show that beta-catenin is neddylated; and inhibiting beta-catenin neddylation increases its nuclea

35 that BBR antagonizes beta-catenin pathway by inhibiting beta-catenin translation and mTOR activity an

36 R inhibitors by decreasing cell survival and inhibiting bFGF, HGF, and IGF1 growth factor rescue and

37 ree other phospho-sites, whose mechanisms in inhibiting binding are not understood.

38 Therefore, inhibiting biofilm growth is the key to completely addre

39 interacts with the N terminus of cI(VP882), inhibiting both cI(VP882) DNA binding and cI(VP882) auto

40 Inhibiting both ventral tegmental area and substantia ni

41 Therefore, inhibiting Brd4 and CDK concurrently with AZD5153 and di

42 Further, inhibiting c-Maf in myeloid progenitors, and consequent

43 tores with cyclopiazonic acid and reduced by inhibiting Ca(2+) influx via Orai channels.

44 ptor 2 (RyR2) inhibitor, dantrolene, without inhibiting Ca(2+) release during systole or affecting Ca

45 ICC-IM responses to EFS were ablated by inhibiting Ca(2+) stores with cyclopiazonic acid and red

46 Silencing or inhibiting Ca/calmodulin kinase II (CaMKII) abolished th

47 ecombination with rates of ~0.2 ps(-1), thus inhibiting cage escape and photoproduct formation.

48 acetylation and tumour cell proliferation by inhibiting calcineurin and NFATc3 activation in mouse an

49 endent phosphorylation of InsP(3) R, thereby inhibiting calcium flux and mPT-dependent necrosis.

50 s of DHODH in an enzymatic assay, while also inhibiting cancer cell growth and viability and activati

51 w MIPs themselves can act as therapeutics by inhibiting cancer growth.

52 ves) is a potential therapeutic approach for inhibiting cardiac dysfunction after MI.

53 rom conserving normal pyroptotic function to inhibiting caspase cleavage to disrupting oligomerizatio

54 g IL-1alpha/beta release from neutrophils by inhibiting caspase-8-dependent apoptosis and Ripk1-Ripk3

55 1 pre-mixed with HMWHA was more effective in inhibiting catabolic events and stimulating anabolic eve

56 Therefore, we hypothesized that inhibiting CD8 T-cell cytotoxicity would reduce disease

57 ay has in regulating cell cycle progression, inhibiting CDK4/6 is an attractive therapeutic strategy.

58 otency, and this can be achieved in vitro by inhibiting CDK8/19 kinase activity.

59 , such as unbalancing protein abundances and inhibiting cell growth but also accelerating genetic div

60 the most potent antitumor effects, markedly inhibiting cell proliferation, survival, and tumor growt

61 sed by, for example, spatial gradients of an inhibiting chemical, we find that dissociating proteins

62 ated degradation of the bonding interface by inhibiting collagenolytic activity.

63 f sequestering leukotriene B(4) (LTB(4)) and inhibiting complement component 5 (C5) activation.

64 Notably, inhibiting cPLA2 synergizes with fatty acid-free diet to

65 vitrification and locally favored structures inhibiting crystallization.

66 adiation, and blocks growth of HNSCC PDXs by inhibiting CSCs.

67 sis by altering immunometabolism in mice and inhibiting CSE or modulating glycolysis are potential ta

68 ved the anti-inflammatory activities through inhibiting cyclooxygenase-2 and lipoxygenase activity.

69 Next, we show that chemogenetically inhibiting D1 medium spiny neurons (MSNs) in the nucleus

70 in MCF10A H-RAS(V12) breast cancer cells by inhibiting de novo proline biosynthesis and impairing sp

71 nterference with menaquinone biosynthesis by inhibiting demethylmenaquinone methyltransferase and the

72 In contrast, netrin-1 promotes survival by inhibiting dependence receptors, including UNC5B, and is

73 Rather than inhibiting device performance, we show that devices up t

74 otentiating radiotherapy and chemotherapy by inhibiting DNA damage repair is proposed as a therapeuti

75 of substrate was the most effective means of inhibiting DNA methylation.

76 We next examined the impact of inhibiting DRN-projecting LHb neurons on reward sensitiv

77 y, locomotion, or anxiety-like behavior, but inhibiting DRN-projecting LHb neurons reduced perseverat

78 obic polymer that was extremely effective at inhibiting drug crystallization, and a less effective, b

79 This inhibiting effect was counteracted by the presence of pr

80 terium Shigella flexneri stalls apoptosis by inhibiting effector caspase activity.

81 te that the specific reduction of H3K9me2 by inhibiting EHMT1/2 during nuclear reprogramming impacts

82 e nucleotides, denoted as (p)ppGpp, which by inhibiting energy requiring molecular pathways help bact

83 Inhibiting ER stress with 4-PBA decreased the effect of

84 a component of the Fanconi anaemia pathway, inhibiting error-prone replicative lesion bypass and int

85 Inhibiting exportin-1 or overexpressing Polkappa increas

86 Here, we report that inhibiting expression of essential genes involved in out

87 Genetically or pharmacologically inhibiting expression of FLIP(L) using siRNA or entinost

88 locked plasmid replication, respectively, by inhibiting expression or function of the plasmid replica

89 sociated with improved task performance, and inhibiting eye movements in humans impaired navigation p

90 via interdomain cross-talk and consequently inhibiting F-actin bundling.

91 al sanitation, but a lack of progress due to inhibiting factors (e.g., limitations in financial resou

92 be able to prevent anaphylaxis in humans by inhibiting FcepsilonRI-mediated signaling.

93 ed their amyloid-prevention capabilities for inhibiting fibrillization of hIAPP.

94 examination, about seven thousand molecules inhibiting five HIV-1 proteins were used to develop regr

95 Furthermore, inhibiting force generation in cancer cells would increa

96 d that GSK3beta suppresses tubular repair by inhibiting FoxM1.

97 serve as a potential therapeutic target for inhibiting GBM invasion.

98 nyl)-1-deoxynojirimycin; MON-DNJ) capable of inhibiting Glu I in vivo is sufficient to prevent death

99 By inhibiting glucose reabsorption in the proximal tubule,

100 e developed to lower blood glucose levels by inhibiting glucose reabsorption in the proximal tubule.

101 Alternatively, inhibiting glutamine metabolism of the MDSCs themselves

102 of beneficial bacteria while simultaneously inhibiting growth of opportunistic ones.

103 ta-lactam concentrations far exceeding those inhibiting growth of the wildtype strain, even in the pr

104 Inhibiting GSDMD is an attractive strategy to curb infla

105 Notably, either inhibiting GSK-3beta or disrupting the D(2)R-DISC1 compl

106 birds had higher titers of hemagglutination-inhibiting (HI) antibodies against the homologous vaccin

107 and HIF-alpha asparagine hydroxylase factor inhibiting HIF (FIH).

108 es a host transcription factor subunit, XPB, inhibiting HIV transcription and blocking reactivation f

109 nfected recipient cells while simultaneously inhibiting HIV transcription.

110 nd inhibits PALB2-BRCA2 interaction, thereby inhibiting HR repair.

111 Thus, Dipah1 and Rab5a represent targets for inhibiting HSC activation and the hepatic tumor microenv

112 Here, we found that inhibiting Hsp90 specifically in the spinal cord enhance

113 During studies with the hydroxylase, factor inhibiting hypoxia-inducible factor 1 (FIH-1), we observ

114 Their effect in inhibiting i) alpha-amylase and alpha-glucosidase activi

115 and IFITM3, in human and mouse cells without inhibiting IFN-induced phosphorylation or nuclear transl

116 Inhibiting IL-1beta or depleting neutrophils, which both

117 ransplantation to determine effectiveness of inhibiting IL-6/IL-6R to ameliorate chronic allograft re

118 n vitro screen, we identified a set of genes inhibiting immune activation.

119 , which has been used as a research tool for inhibiting immune cell trafficking.

120 tory T cell-inducing molecule retinoic acid, inhibiting inflammatory cytokine production, and making

121 I or Mda5 deficiency reduced HSPC numbers by inhibiting inflammatory signals that were in turn enhanc

122 e CD47-SIRPA axis suppresses phagocytosis by inhibiting inside-out activation of integrin signaling i

123 Inhibiting IRE1alpha blocked stellate cell activation, w

124 ry protein MRAP2 altered GHSR1a signaling by inhibiting its constitutive activity, as well as by enha

125 preventing these drugs from binding heme and inhibiting its detoxification.

126 rget of anticancer and anti-obesity drugs by inhibiting its DNA-binding activities.

127 ture of the ligand, with minor modifications inhibiting its formation.

128 n through regulation of its promoters and by inhibiting its presentation through interaction with the

129 3 enhances the anti-inflammatory response by inhibiting JAK/STAT-signaling activation.

130 TRADD modulates cellular homeostasis by inhibiting K63-linked ubiquitination of beclin 1 mediate

131 e predicted c-di-GMP-binding protein LapD in inhibiting LapG-dependent dispersal.

132 ore the therapeutic potential of transiently inhibiting LDH during adoptive T cell-based immunotherap

133 binding site in UTRN 3'UTR, with the goal of inhibiting let-7c interaction with UTRN mRNA and thus up

134 These results support the idea that inhibiting LHb projections to the DRN provides animals w

135 Here, we show for two fibril inhibiting ligands, an ionic molecular tweezer and a hyd

136 arency results from structural partial order inhibiting light scattering, while preserving mechanical

137 Inhibiting LIN9 genetically or by suppressing its expres

138 activity of Delta(9)-tetrahydrocannabinol by inhibiting local autophagy.

139 of atherosclerosis induced periodontitis by inhibiting local, systemic and vascular inflammation, as

140 We experimentally tested the model by inhibiting low dose infection with the drug tenofovir, w

141 Inhibiting LOX reduces collagen cross-linking and fibron

142 These results suggest that inhibiting LSD1 via sequestration contributes to tau-med

143 perativity, reducing cell cycle pathways and inhibiting lung cancer cell proliferation and migration.

144 3a has the opposite effect, enhancing M1 and inhibiting M2 gene expression.

145 and displacing UHRF1 from chromatin, thereby inhibiting maintenance DNA methylation.

146 o promote their own growth and survival, and inhibiting MALT1 reduces the viability and growth of the

147 Therapeutically inhibiting matrix metalloproteases (MMPs) suppressed bot

148 Inhibiting membrane association of RAS has long been con

149 may represent a valid therapeutic target for inhibiting metastasis.

150 lture and in pig manure while simultaneously inhibiting methane and odorant (H(2)S and VOC) emissions

151 ilum is an obligate intracellular bacterium, inhibiting microbe-host cell interactions that facilitat

152 e in plant defense against phytopathogens by inhibiting microbial polygalacturonases (PGs).

153 ommunity dispersal, isolating Antarctica and inhibiting microorganism and nutrient deposition from lo

154 on in mineralized dental tissues rather than inhibiting mineral formation in the ligament, which may

155 Inhibiting mitochondrial translation is known to increas

156 tatic liver promotes BA-induced pathology by inhibiting MLL4 expression.

157 omas on MNT for survival suggests that drugs inhibiting MNT could significantly boost therapy of MYC-

158 deeper discrimination architectures without inhibiting model convergence.

159 U.521 is capable of potently and selectively inhibiting mouse and human cGAS in cell lines and human

160 Inhibiting mTOR activity with rapamycin rescued the gene

161 Taken together, our data suggest that inhibiting multiple pathways by selected individual smal

162 e in downregulating DUX4 protein expression, inhibiting muscle fibrosis, and consequently rescuing mu

163 Inhibiting MYC expression with the BET bromodomain inhib

164 impaired the maturation of NLGN4 protein by inhibiting N-linked glycosylation at an adjacent residue

165 We now demonstrate that inhibiting NAA synthesis by intracisternal administratio

166 e of Ab responses by promoting apoptosis and inhibiting necroptosis in B cells.

167 ation, we demonstrate that pharmacologically inhibiting necroptosis or interferon signaling protects

168 ed synaptic plasticity, which was blocked by inhibiting neural lactate uptake.

169 ts primary role is to protect lung tissue by inhibiting neutrophil elastase.

170 fic adhesion properties to hSFs, reversed by inhibiting NF-kB translocation to the nucleus.

171 or gene editing and tumor evolution, and how inhibiting NMD may be an effective strategy to increase

172 Blocking adenosine production by inhibiting nucleotide-metabolizing enzymes, such as ecto

173 abilize the active dimeric unit, accordingly inhibiting or stimulating RNase activity.

174 proliferation in vitro, while simultaneously inhibiting osteoclastogenesis.

175 ncluding reciprocal (inhibitory interneurons inhibiting other interneurons) and feedforward (inhibito

176 Inhibiting OTULIN or Wnt/beta-catenin sensitizes triple-

177 thesis that SOD3 preserves HA homeostasis by inhibiting oxidative and enzymatic hyaluronidase-mediate

178 and that these compounds might be useful for inhibiting P-Rex1 in other experimental contexts.

179 Thus, inhibiting p38 in elderly individuals rejuvenated their

180 g in Ach resistance that could be rescued by inhibiting p38 MAPK.

181 Temporarily inhibiting p53 function offers a window of opportunity f

182 has demonstrated a new function of TRIM21 in inhibiting p53 protein synthesis by degrading the RNA-bi

183 ain-of-function in cooperating with MDMX and inhibiting p53, and partial loss-of-function in suppress

184 sue damage and inflammation of COVID-19, and inhibiting PANoptosis protected mice from this pathology

185 ile concurrently activating somatostatin and inhibiting parvalbumin interneurons.

186 w strategy to restore anti-tumor immunity by inhibiting pathways of force-generation.

187 Here we show that inhibiting PCSK9-a key protein in the regulation of chol

188 Most research has centered on inhibiting PD-1 on T cells, but there is increased inter

189 In vitro, PDE10A deficiency or inhibiting PDE10A with selective inhibitor TP-10, attenu

190 We hypothesized that inhibiting PDE9a activity ameliorates diastolic dysfunct

191 tatins as tuberculosis preventive therapy by inhibiting PDIM spread.

192 Inhibiting peptidases may be an attractive method to enh

193 ycobactericidal activity, but as a result of inhibiting phagocytosis.

194 concentrations of S1P in vitro In addition, inhibiting phospholipase A2 (PLA2) or lipoxygenase (Lox)

195 Aspirin prevents thrombosis by inhibiting platelet cyclooxygenase (COX)-1 activity and

196 Because inhibiting platelet necrosis does not compromise hemosta

197 Abeta-induced impairments, and suggest that inhibiting PME-1 may constitute a viable therapeutic ave

198 ns) and feedforward (inhibitory interneurons inhibiting principal neurons) connections, are crucial i

199 However, inhibiting proteasome activity can lead to an increase i

200 Inhibiting protein elongation with SVC112 reduces tumor

201 Plant cell wall-associated polygalacturonase-inhibiting proteins (PGIPs) are widely distributed in th

202 a enhancing de novo purine synthesis because inhibiting purine synthesis reversed the effects of UHMK

203 stream target of WNT5B, which was blocked by inhibiting RAC1, a prominent regulator of C-JUN activati

204 gramming by shifting glycolytic pathways and inhibiting reactive oxygen species (ROS) production in P

205 pproved antiparasitic agent, is effective at inhibiting replication of several HAdV types in vitro Th

206 ur data revealed that SPARC promoted GSIS by inhibiting RGS4 in pancreatic beta cells.

207 al RNAs by occupying m(6)A-modified RNAs and inhibiting RIG-I recognition.

208 These results support the feasibility of inhibiting RNA activity using small molecules that prefe

209 ration enhancing and the other configuration inhibiting RNA unwinding compared with the unconstrained

210 Therefore, TET2 and EZH2 play a tumor-inhibiting role in AML that affects CIN via MAD2 and CDC

211 r levels of reactive oxygen species (ROS) by inhibiting ROS scavenging.

212 al perceptual decision-making by transiently inhibiting SC activity during an orientation change dete

213 Inhibiting SC during this 100-ms period caused a contral

214 Psychometric analysis revealed that inhibiting SC visual activity significantly increased de

215 Here, we investigate the effects of inhibiting sEH with 1-trifluoromethoxyphenyl-3-(1-propio

216 t monomeric, beta-arrestin2 increases tau by inhibiting self-interaction of the autophagy cargo recep

217 s target the serotonin transporter (SERT) by inhibiting serotonin reuptake.

218 Inhibiting SFK signaling blocks both the expulsion of ap

219 Inhibiting Shp1 phosphatase activity in the absence of E

220 ibutes to neurodegeneration and suggest that inhibiting sphingolipid synthesis might provide a useful

221 Furthermore, we found that inhibiting spindle assembly checkpoint protein Msp1 part

222 prevents termination by phosphorylating and inhibiting SSUP-72.

223 To identify Acrs capable of inhibiting Staphylococcus aureus Cas9 (SauCas9), an alte

224 otrusions could be effectively suppressed by inhibiting subcellular mitochondrial trafficking.

225 ylation (OXPHOS) with BDQ and simultaneously inhibiting substrate level phosphorylation via genetic d

226 possess blood glucose lowering properties by inhibiting sugar transporters in the small intestine and

227 filgotinib suppresses HIV-1 transcription by inhibiting T cell activation and by modulating RNA splic

228 attracting cytotoxic T cells and capable of inhibiting T cell proliferation more than macrophages cu

229 entry into the tricarboxylic acid cycle and inhibiting terminal effector and exhaustion programs, in

230 hibited tECM-driven TGFBR2 expression, while inhibiting TGF-beta signaling decreased tECM-mediated ex

231 In this model, inhibiting TGFbetaR signaling does not significantly alt

232 They function by inhibiting the activity of the Ca(2+)/calmodulin-depende

233 cell motility and promotes S-phase entry by inhibiting the activity of the master regulator, CtrA.

234 arbose, miglitol, and voglibose are used for inhibiting the activity of these enzymes, however, alter

235 the pore-forming proteins Bax and Bak and by inhibiting the anti-apoptotic proteins Bcl-XL, Bcl-2 and

236 resolution live cell imaging, we found that inhibiting the catalytic activity of CESA6 by ES20 treat

237 Its proposed function is inhibiting the classical protein nuclear import pathway

238 eostasis and T(H)2 cytokine production, thus inhibiting the development of ILC2-mediated AHR.

239 lling protocols for the synthesis of either, inhibiting the development of PET radioligands.

240 reduced thrombin-mediated EC permeability by inhibiting the disassembly of VE-cadherin at adherens ju

241 z activates CYP46A1 at low drug levels while inhibiting the enzyme activity at the high dose used in

242 H action arrested vitellogenesis, in part by inhibiting the expression of doublesex (Dsx), a key tran

243 es, suppressing hypoxic glycogen levels, and inhibiting the expression of the sorbitol dehydrogenase-

244 We predicted that inhibiting the fatty acid desaturase SCD1 may selectivel

245 ated medicinal chemistry efforts directed at inhibiting the function of specific single-protein and m

246 The inhibitors are also capable of inhibiting the GOx-catalyzed reduction of the ABTS radic

247 lf, here we have examined the feasibility of inhibiting the Hsp70 co-chaperone DNAJA1 as a novel anti

248 rbing mitotic progression and simultaneously inhibiting the hydrolysis of 8oxodGTP.

249 Moreover, we demonstrate that by inhibiting the interaction between CD44 and its ligand h

250 By contrast, inhibiting the ISR by mutating the eIF2alpha phosphoryla

251 site, genetically(11) and pharmacologically inhibiting the ISR kinases(14-17), or mimicking reduced

252 known to downregulate cytokine signaling by inhibiting the JAK-STAT pathway.

253 In contrast, inhibiting the JAK/STAT inflammatory pathway with tofaci

254 Finally, we show that inhibiting the maturation cycle of tubulin by using a po

255 (NM2C) (MYH14) to alter actin organization, inhibiting the mechanical program of metastasis.

256 indle by clathrin stabilizes microtubules by inhibiting the microtubule depolymerase MCAK.

257 d that they prevent expression of the tic by inhibiting the nascent excitation released by the tic ge

258 viral infection and inflammatory stimuli by inhibiting the NF-kappaB and type I interferon (IFN-I) p

259 CK1alpha has a well-established role in inhibiting the p53 tumor suppressor by binding to MDMX a

260 Specifically, inhibiting the palmitoylation/depalmitoylation cycle is

261 Hence, inhibiting the PEX14-PEX5 protein-protein interaction (P

262 Inhibiting the production of Wnt-ligands reduces the amo

263 ions, one could discover common strategy for inhibiting the replication of related flaviviruses.

264 surface iridium sites, whilst significantly inhibiting the surface cation corrosion during electroca

265 inostat, disrupts the premetastatic niche by inhibiting the trafficking of MDSCs through the downregu

266 transformation of LMP1-expressing B cells by inhibiting their differentiation to plasma cells.

267 elf-renewal of stem and progenitor cells and inhibiting their differentiation.

268 ters to induce their gene expression, and by inhibiting their interaction with phyB in the light.

269 cycle arrest in MF/SS malignant lymphocytes, inhibiting their proliferation but not their survival.

270 ked cytotoxic T-cell and NK-cell activation, inhibiting their proliferation, cytokine production, and

271 Furthermore, inhibiting these neurons impairs punishment-based learni

272 not under low-stress circumstances, and that inhibiting these neurons may promote persistence in acti

273 and germination and describes strategies for inhibiting these processes to prevent C. difficile infec

274 a means to examine the biological effects of inhibiting these two important enzymes with a single mol

275 Inhibiting this interaction may inhibit disease progress

276 Since Akt can activate beta-catenin, inhibiting this interaction might target therapy-resista

277 alin decreased mitochondrial permeability by inhibiting this interaction.

278 ory mediators and chemotherapeutic drugs but inhibiting this pathway does not alter nerve injury-indu

279 Inhibiting this process is an emerging strategy for mana

280 ors can exert opposing effects, promoting or inhibiting tissue immunity.

281 s reveal that TTP plays an important role in inhibiting TNFalpha/JNK-induced necrosome signaling and

282 FcepsilonRI expression on dendritic cells by inhibiting transcription factor binding to its promotor

283 ion by sterically hindering tRNA binding and inhibiting translation elongation.

284 were attenuated by TRPA1 inhibition, whereas inhibiting TRPV3 exacerbated ERS and cytotoxicity.

285 However, because inhibiting TSHR downregulation with combined expression

286 In summary, EBV BGLF2 interacts with Tyk2, inhibiting Tyk2, STAT1, and STAT3 phosphorylation and im

287 This latter strategy of inhibiting unproductive decay channels was pursued to im

288 are as effective as partial agonist drugs in inhibiting vascular thrombosis in humanized mice, but ne

289 f these correlated networks was disrupted by inhibiting vCA1 shock responses during memory encoding.

290 stinct antigenic sites that are critical for inhibiting viral entry into cells.

291 TG have been shown to play a crucial role in inhibiting viral reactivation, and with a portion of the

292 attenuates EMCV-mediated beta-cell lysis by inhibiting viral replication.

293 phila gypsy activation and pharmacologically inhibiting viral reverse transcriptase activity prevents

294 2-AG directly modulates pathogen function by inhibiting virulence programs essential for successful i

295 1 particles and reduces HIV-1 infectivity by inhibiting virus-cell fusion.

296 MLAV VP35 behaved like EBOV and MARV VP35s, inhibiting virus-induced activation of the interferon be

297 Inhibiting VISTA- and PD-L1-signaling relieved immune su

298 Lesioning or chemogenetically inhibiting VTA GABAergic (VTA(Vgat)) neurons generated p

299 ubiquitylation-like protein modification, in inhibiting Wnt/beta-catenin signaling.

300 morigenesis in the Apc(Min/+) mouse model by inhibiting Wnt/beta-catenin signaling.