ライフサイエンスコーパス: inhibition of apoptosis

1 angiogenesis through the decline of TSP1 and inhibition of apoptosis.

2 ent via its stimulation of proliferation and inhibition of apoptosis.

3 , 9%; P = 0.009) that was associated with an inhibition of apoptosis.

4 wn-regulation of inflammatory mediators, and inhibition of apoptosis.

5 hroid progenitors in the bone marrow through inhibition of apoptosis.

6 activity that contributed to Op-IAP-mediated inhibition of apoptosis.

7 This resistance may be in part due to inhibition of apoptosis.

8 e of this activated pathway is the transient inhibition of apoptosis.

9 st cell death 1 as well as a reversal of the inhibition of apoptosis.

10 gets, leading to altered cell metabolism and inhibition of apoptosis.

11 eonatal lung from acute hyperoxic injury via inhibition of apoptosis.

12 le of the NF-kappaB signaling pathway in the inhibition of apoptosis.

13 ll (HSC) phenotype by both proliferation and inhibition of apoptosis.

14 dentify the default death resulting from the inhibition of apoptosis.

15 es induced by ischemia or 6-OHDA through the inhibition of apoptosis.

16 n resulted in mutation-specific and variable inhibition of apoptosis.

17 eral stages of tumour development, including inhibition of apoptosis.

18 CMV MIEPs can activate Akt, resulting in the inhibition of apoptosis.

19 hatidylinositol 3-kinase (PI3K)/Akt-mediated inhibition of apoptosis.

20 activator of the PI3K/AKT pathway leading to inhibition of apoptosis.

21 ration, monocyte adhesion, angiogenesis, and inhibition of apoptosis.

22 decrease of c-FLIP(L) expression results in inhibition of apoptosis.

23 maintenance of cellular viability in part by inhibition of apoptosis.

24 ization of cellular calcium homeostasis, and inhibition of apoptosis.

25 to require both increased proliferation and inhibition of apoptosis.

26 ith CAML is required for its function in the inhibition of apoptosis.

27 tion by interleukin-1 (IL-1), contributes to inhibition of apoptosis.

28 lpha (TGF-alpha)-dependent cell recovery and inhibition of apoptosis.

29 ediate mitogenesis, cell transformation, and inhibition of apoptosis.

30 osphorylation of Akt, a key event leading to inhibition of apoptosis.

31 important effect of HBx activation of AKT is inhibition of apoptosis.

32 coordinated promotion of cell migration and inhibition of apoptosis.

33 sulted in maintenance of BCL2 expression and inhibition of apoptosis.

34 sociated previously with cell growth and the inhibition of apoptosis.

35 tion of cyclin D1, was also required for the inhibition of apoptosis.

36 ted and result in cellular proliferation and inhibition of apoptosis.

37 o-caspase-9 as a new target for IAP-mediated inhibition of apoptosis.

38 activation and myelin degradation as well as inhibition of apoptosis.

39 acity of MEQ-transformed Rat-2 cells through inhibition of apoptosis.

40 ressor function, cellular proliferation, and inhibition of apoptosis.

41 agonized both SCF-mediated proliferation and inhibition of apoptosis.

42 on of GATA-1 had no detectable effect on Epo inhibition of apoptosis.

43 ell proliferation by IGF-1, but rather to an inhibition of apoptosis.

44 , even though it abrogated the IGF-I-induced inhibition of apoptosis.

45 bcl-2, an oncogene with known potential for inhibition of apoptosis.

46 rst data associating TAM resistance with the inhibition of apoptosis.

47 resistance to MRTX1133 treatment due to the inhibition of apoptosis.

48 urea and creatinine that were not altered by inhibition of apoptosis.

49 system, cell signaling, immune function and inhibition of apoptosis.

50 by promoting pre-adipocyte proliferation and inhibition of apoptosis.

51 of genes implicated in both stimulation and inhibition of apoptosis.

52 cogene in many tumors, primarily through the inhibition of apoptosis.

53 nitric-oxide synthase (eNOS) expression, and inhibition of apoptosis.

54 -stimulated AKT Thr(308) phosphorylation and inhibition of apoptosis.

55 inhibiting Chk1 activation with concomitant inhibition of apoptosis.

56 rough accelerated cellular proliferation and inhibition of apoptosis.

57 absence of this microRNA by dorsal-specific inhibition of apoptosis.

58 ent activation of beta-catenin signaling and inhibition of apoptosis.

59 gene products and may be associated with the inhibition of apoptosis.

60 RNA processing, growth factor recycling, and inhibition of apoptosis.

61 emotaxis, stress response, angiogenesis, and inhibition of apoptosis.

62 IL-6, which enhances tumor growth in vivo by inhibition of apoptosis.

63 These results suggest myocardial salvage by inhibition of apoptosis.

64 ting other cellular processes in addition to inhibition of apoptosis.

65 fluidity, promotion of neurite extension and inhibition of apoptosis.

66 ell cycle arrest, autophagy, DNA repair, and inhibition of apoptosis.

67 ected zymogen procaspase 3, concomitant with inhibition of apoptosis.

68 up-regulation of antiapoptotic Bcl(xL), and inhibition of apoptosis.

69 proteins and contribute to commitment to or inhibition of apoptosis.

70 E-BP1, leading to cell cycle progression and inhibition of apoptosis.

71 e changes in the integrin signaling pathway, inhibition of apoptosis, acquisition of tumorigenic cell

72 In addition to the inhibition of apoptosis, activation of either the CSF1R/

73 ent phosphorylation of the EPOR and JAK2 and inhibition of apoptosis after withdrawal of IL-2.

74 nes associated with cell cycle induction and inhibition of apoptosis, alters the expression of genes

75 3-kinase (PI 3-kinase) is essential for the inhibition of apoptosis, although this enzyme does not b

76 ccessibility and gene expression, leading to inhibition of apoptosis and activation of oncogenic path

77 It can further prevent inhibition of apoptosis and allow cells to survive nutri

78 The possibilities are also discussed that inhibition of apoptosis and altered adhesive properties

79 TIPRL, such as regulation of mTOR signaling, inhibition of apoptosis and biogenesis and recycling of

80 This pro-survival function involves inhibition of apoptosis and caspase activation.

81 This was achieved in part through inhibition of apoptosis and caspase cleavage.

82 me c release occurred in association with an inhibition of apoptosis and caspase-3-like activation.

83 le progression but reduced estrogen-mediated inhibition of apoptosis and cell growth.

84 e relationship between LFG and Bcl-XL in the inhibition of apoptosis and found that LFG protects only

85 ivity of the p38 MAPK, provided only partial inhibition of apoptosis and had no effect on necrosis.

86 lular thioredoxin has been implicated in the inhibition of apoptosis and in a decrease in the sensiti

87 terotetramer, thus resulting in irreversible inhibition of apoptosis and inflammation.

88 combinant human activated protein C, such as inhibition of apoptosis and leukocyte recruitment, remai

89 The inhibition of apoptosis and maintenance of cell function

90 Persistent infection can be a by-product of inhibition of apoptosis and may significantly impact the

91 Pharmacological and genetic inhibition of apoptosis and necrosis lessens infarct siz

92 s, our data suggest that CK2 participates in inhibition of apoptosis and negatively regulates caspase

93 MAPKK function is necessary for optimal IL-3 inhibition of apoptosis and optimal IL-3 stimulation of

94 include protumorigenic functions, including inhibition of apoptosis and promotion of proliferation,

95 uctural basis for a dual role of survivin in inhibition of apoptosis and regulation of cell division.

96 t of impaired akt2 expression results in the inhibition of apoptosis and rescue of the morphant embry

97 ation by other mechanisms than BCL2-mediated inhibition of apoptosis and suggesting a shared biologic

98 lts of more complex mapping studies in which inhibition of apoptosis and the enhanced spontaneous rea

99 ive processes (e.g., antiviral responses and inhibition of apoptosis) and possible role in the pathog

100 n of maintenance of proliferation potential, inhibition of apoptosis, and blocking of differentiation

101 AKT/PKB is implicated in the inhibition of apoptosis, and cell lines and tumors with

102 upregulation of survivin was associated with inhibition of apoptosis, and downregulation of survivin

103 expression of genes involved in cell growth, inhibition of apoptosis, and embryogenesis and by increa

104 effects are accompanied by the p38-mediated inhibition of apoptosis, and if so, what signaling pathw

105 cers (CRCs) frequently display APC mutation, inhibition of apoptosis, and increased expression of the

106 and ERK, is crucial for cell proliferation, inhibition of apoptosis, and migration of cells.

107 ement of Msi-1 in cancer cell proliferation, inhibition of apoptosis, and mitotic catastrophe, sugges

108 volve the reduction of oxidative stress, the inhibition of apoptosis, and possibly the maintenance of

109 e activation of the survival signal PKB/Akt, inhibition of apoptosis, and promotion of cell cycle pro

110 ic remodeling, stimulation of proliferation, inhibition of apoptosis, and regulation of angiogenesis.

111 omains, mediated phosphorylation of PKB/akt, inhibition of apoptosis, and replication of 32DIR cells

112 10 expression in B-cell NHL and, through the inhibition of apoptosis, appears responsible for the neg

113 therapies designed to ameliorate disease by inhibition of apoptosis are more likely to succeed in MD

114 st that domains of the receptor required for inhibition of apoptosis are necessary but not sufficient

115 ell cycle checkpoint in combination with the inhibition of apoptosis are two principal requirements f

116 Despite its stability and effect on the inhibition of apoptosis, arginine GlcNAcylation did not

117 t VDAC1 oligomerization, concomitant with an inhibition of apoptosis as induced by various means and

118 gnaling, stimulation of cellular growth, and inhibition of apoptosis as well as transformation of cel

119 of 3-aminobenzamide cannot be attributed to inhibition of apoptosis, as apoptotic parameters (caspas

120 SF/HGF occurred at least in part through an inhibition of apoptosis, as evidenced by diminished term

121 B. henselae-mediated inhibition of apoptosis, as indicated by gene expression

122 Sustained inhibition of apoptosis at 72 h was seen only with R1881

123 ease in cell proliferation and a significant inhibition of apoptosis at day 4 after injury compared t

124 Moreover, IL-7-mediated inhibition of apoptosis at increasing concentrations of

125 ontributes to carotid remodeling not only by inhibition of apoptosis but also via regulation of immun

126 ficantly improved cellular viability through inhibition of apoptosis but had minimal effect on hypoxi

127 in with essential roles in cell division and inhibition of apoptosis, but the molecular underpinnings

128 ent of caspases was confirmed by significant inhibition of apoptosis by a caspase inhibitor, and by d

129 By contrast inhibition of apoptosis by anti-CD40 occurs even though

130 ntrast, upregulation of Bcl-2 expression and inhibition of apoptosis by Brn-3a is antagonized more by

131 It is likely that inhibition of apoptosis by C. burnetii represents an imp

132 o reduced 65 to 69% by aLLN, indicating that inhibition of apoptosis by calpain inhibitors is indepen

133 Reduced levels of CARP-1 result in inhibition of apoptosis by CD437 or adriamycin, whereas

134 The inhibition of apoptosis by COX-2 was concomitant with pr

135 s directly demonstrating that the targets of inhibition of apoptosis by CrmA and Bcl-2 are upstream o

136 with E1A conserved regions (CR) 1 and 2, and inhibition of apoptosis by E1B proteins are required for

137 tisense-dependent depletion of CARP-1 causes inhibition of apoptosis by ERRP.

138 Rather than promoting inflammation, inhibition of apoptosis by expression of the Bcl-X(L) pr

139 role in the pathogenesis of asthma with the inhibition of apoptosis by GM-CSF and IL-5 proposed as a

140 Inhibition of apoptosis by HSV was accompanied by marked

141 In contrast, inhibition of apoptosis by IGF-1 in DiFi cells was sensi

142 The inhibition of apoptosis by IGF-I is believed to be parti

143 In summary, inhibition of apoptosis by Nef can lead to persistence o

144 Inhibition of apoptosis by NMDA was blocked by the phosp

145 We postulated that the mechanism of the inhibition of apoptosis by NO would include an effect on

146 The mechanism of inhibition of apoptosis by Nr13 is likely to involve a c

147 Inhibition of apoptosis by overexpression of the insulin

148 The inhibition of apoptosis by Pgp was associated, however,

149 residue is also required for pUL36-mediated inhibition of apoptosis by preventing proteolytic activa

150 In our previous study, we established that inhibition of apoptosis by the general caspase inhibitor

151 caspase cleavages, electron microscopy, and inhibition of apoptosis by the pancaspase inhibitor qVD-

152 nces were required for kinase activation and inhibition of apoptosis by transfecting wild-type (AT1Rw

153 rsion rate of benign tumors, suggesting that inhibition of apoptosis can contribute to tumor progress

154 Conversely, inhibition of apoptosis can lead to the development of a

155 Here, we address whether transient inhibition of apoptosis can serve as a safe but efficien

156 tributable to stimulation of cell growth and inhibition of apoptosis caused by serum starvation.

157 ells cultured in the presence of zinc showed inhibition of apoptosis coincident with a marked increas

158 However, the inhibition of apoptosis, combined with TLR3 activation,

159 Within these cells, EBV-mediated inhibition of apoptosis correlates with an up-regulation

160 Inhibition of apoptosis could be due to released IL-3, I

161 infected cells as part of the "lethal hit," inhibition of apoptosis could represent an effective imm

162 ocardium participate in survival mechanisms (inhibition of apoptosis, cytoprotection, cell growth, an

163 In embryos, however, inhibition of apoptosis decreases the length of the noto

164 Y294002 and PD98059 did not produce additive inhibition of apoptosis delay.

165 a direct link between kinase activation and inhibition of apoptosis dependent on amino acids 221 and

166 f c-rel-deficient B cells, and show that the inhibition of apoptosis does not necessarily confer hype

167 Partial inhibition of apoptosis due to LAQ824 or Apo-2L/TRAIL ex

168 Thus, Epo-dependent mitogenesis and inhibition of apoptosis each depend critically upon only

169 ns lead to increased proliferation, enhanced inhibition of apoptosis, escape from immune surveillance

170 PI 3-kinase mediates IL-3- and IGF-I-induced inhibition of apoptosis, FDCP-1/Mac-1 cells were incubat

171 trate that RUNX3 plays a pivotal role in the inhibition of apoptosis found in the beta-catenin S45F m

172 1 pathway is essential for cell survival and inhibition of apoptosis; however, alterations of Akt/AKT

173 Akt survival signaling pathways, leading to inhibition of apoptosis, hyperplasia, and tumor formatio

174 Hsp70s have been linked to inhibition of apoptosis (i.e., cancer) and diseases asso

175 ts in astrocytes were prevented, namely: (i) inhibition of apoptosis, (ii) increase on ATP generation

176 results, which define a novel mechanism for inhibition of apoptosis, implicate parallel, interacting

177 ase activities and increased GSH levels with inhibition of apoptosis in all five model systems.

178 f the 8.3-kb LAT gene is sufficient for both inhibition of apoptosis in an in vitro transient-transfe

179 studies are associated with the induction or inhibition of apoptosis in azoxymethane (AOM)-induced co

180 Inhibition of apoptosis in C. burnetii-infected cells di

181 nism of 17beta-estradiol (estrogen)-mediated inhibition of apoptosis in C6 (rat glioma) cells followi

182 pression of the HDAC7 target, Nur77, and the inhibition of apoptosis in CD4+CD8+ thymocytes.

183 ed link between antigen-receptor binding and inhibition of apoptosis in CLL.

184 Inhibition of apoptosis in corneas stored at 4 degrees C

185 Permanent inhibition of apoptosis in donor cells caused by the los

186 related protein 1 (SFRP1) contributes to the inhibition of apoptosis in fibroblast populations.

187 the addition of SFRP1 may contribute to the inhibition of apoptosis in fibroblast-related cells.

188 mutants may be functionally important in the inhibition of apoptosis in Msx1/2 mutants.

189 cles are positive for apoptosis markers, and inhibition of apoptosis in muscles prevents to a signifi

190 ystemically increased cell proliferation and inhibition of apoptosis in myeloid lineage cells.

191 Inhibition of apoptosis in normal cultures resulted in e

192 ent than their wild-type counterparts in the inhibition of apoptosis in primary mouse T cells and in

193 pression promotes cell growth, invasion, and inhibition of apoptosis in renal cancer cells.

194 ogenous HSH2 expression within 12 h, whereas inhibition of apoptosis in response to CD40-mediated sig

195 the activities of all family members led to inhibition of apoptosis in T cells.

196 of multiple apoptotic signals, and implicate inhibition of apoptosis in the pathogenesis of APL.

197 mplementary functions in MyoD activation and inhibition of apoptosis in the somitic mesoderm and in r

198 middle T antigen was partially defective for inhibition of apoptosis in these cells.

199 Inhibition of apoptosis in vitro delayed, but did not pr

200 The AhR-mediated inhibition of apoptosis in vitro was associated with a c

201 Importantly, deliberate inhibition of apoptosis in wild-type animals significant

202 Several HSV genes are involved in the inhibition of apoptosis, including Us5, which encodes gl

203 l advantage to transformed cells through the inhibition of apoptosis, increased attachment to extrace

204 phenotypes associated with cancer, including inhibition of apoptosis, increased proliferation, and ac

205 pithelial cells resulted in a dose-dependent inhibition of apoptosis induced by etoposide, UV-irradia

206 DBC1 expression potentiates SIRT1-dependent inhibition of apoptosis induced by genotoxic stress.

207 sufficient for physical interaction with and inhibition of apoptosis induced by HID.

208 ar-4 in HeLa cells resulted in a significant inhibition of apoptosis induced by various proapoptotic

209 n this report, we investigated whether bcl-2 inhibition of apoptosis involves regulation of TIMP expr

210 are the ability to induce apoptosis and that inhibition of apoptosis is a mechanism of tumor promoter

211 We demonstrate that TolC-mediated inhibition of apoptosis is an active process and not due

212 We demonstrate that this robust inhibition of apoptosis is caused by Q97-mediated accumu

213 Inhibition of apoptosis is critical for carcinogenesis.

214 These results suggest that the inhibition of apoptosis is essential for this mode of vi

215 The inhibition of apoptosis is generally believed to be a ma

216 This inhibition of apoptosis is in part dependent on the acti

217 TIMP-1 inhibition of apoptosis is not IL-10 dependent.

218 However, inhibition of apoptosis is not sufficient to prevent eth

219 Whether this neuroprotection is due to inhibition of apoptosis is unknown.

220 Inhibition of apoptosis is used as an example of the pro

221 This indicates Bcl2 inhibition of apoptosis is, therefore, downstream of cas

222 , whereas RB tumor promoting function, i.e., inhibition of apoptosis, is inactivated by caspase cleav

223 Inhibition of apoptosis leads to a switch to the RIP1-de

224 This inhibition of apoptosis led to significantly more macros

225 Because inhibition of apoptosis may be an essential step in tumo

226 Securing an intracellular niche through the inhibition of apoptosis may be an important mechanism ut

227 show that abnormal cell differentiation and inhibition of apoptosis may contribute to the developmen

228 ollectively, these findings suggest that the inhibition of apoptosis may lead to an increased express

229 the induction of apoptosis and vMIA-mediated inhibition of apoptosis may occur subsequent to this eve

230 Inhibition of apoptosis may represent a major aspect of

231 and proteasomal degradation and so releases inhibition of apoptosis mediated by cIAP.

232 Toso appeared limited to inhibition of apoptosis mediated by members of the TNF r

233 - or extracellular mutations caused dominant inhibition of apoptosis mediated by wild-type Fas.

234 ative therapeutic intervention for RA is the inhibition of apoptosis-mediated cartilage degradation.

235 nucleotide exchange factors (Map and EspM), inhibition of apoptosis (NleH and NleD), interference wi

236 o alteration of specific cell cycle stage or inhibition of apoptosis, nor by induction of the DNA dam

237 (e) Anti-CD40 inhibition of apoptosis occurs without alteration in ant

238 arvedilol on the ischemic myocardium include inhibition of apoptosis of cardiomyocytes and, if so, to

239 The inhibition of apoptosis of infected host cells is a well

240 ng vacuoles with lysosomal compartments, ii) inhibition of apoptosis of infected mononuclear cells, a

241 d intermediate PRLr were equivalent in their inhibition of apoptosis of the Ba/F3 transfectants after

242 Inhibition of apoptosis or abnormal cell survival can re

243 ion of nonalcoholic fatty liver disease, and inhibition of apoptosis partially protects against liver

244 Correlating with the inhibition of apoptosis, PKC-alpha transfectants exhibit

245 Inhibition of apoptosis plays an important role in the c

246 upregulation of late viral gene expression, inhibition of apoptosis, prevention of aggregation of no

247 (HSP70) protects the gastric mucosa through inhibition of apoptosis, proinflammatory cytokines, and

248 ngosine-1-phosphate plays important roles in inhibition of apoptosis, promotion of cell proliferation

249 Activation of PI3-kinase leads to inhibition of apoptosis, promotion of cell survival, and

250 noid growth and differentiation, whereas the inhibition of apoptosis rescued Mettl14-deleted mice and

251 Inhibition of apoptosis resulted in more persistent self

252 nhibition of caspase activity and subsequent inhibition of apoptosis results in increased viral expre

253 If this postulate is correct, then inhibition of apoptosis should allow recovery of beta-ce

254 JNK inhibition correlated with inhibition of apoptosis signal-regulating kinase 1 (ASK1

255 Inhibition of apoptosis signal-regulating kinase 1, a se

256 ion by PP1 of SCF-mediated proliferation and inhibition of apoptosis suggests that Src family kinases

257 In addition to its role in inhibition of apoptosis, survivin also regulates mitosis

258 y described an alternative mechanism of XIAP inhibition of apoptosis that depends on the selective ac

259 ization of PTHrP has been associated with an inhibition of apoptosis, the ability of full-length PTHr

260 h was characterized by genes involved in the inhibition of apoptosis, the actin cytoskeleton, and NF-

261 Despite inhibition of apoptosis, the immunotoxin is still capabl

262 he first included Akt and Bad, leading to an inhibition of apoptosis; the second included the mitogen

263 ys important roles in cell proliferation and inhibition of apoptosis, this pathway has emerged as a p

264 These results provide evidence that inhibition of apoptosis through Bcl-x(L) overexpression

265 ed that ischemic preconditioning protects by inhibition of apoptosis through down-regulation of caspa

266 ic protection against prolonged ischemia via inhibition of apoptosis through down-regulation of caspa

267 ould or would not occur allowed us to relate inhibition of apoptosis to a complete withdrawal from th

268 onstrate a therapeutic benefit of late-stage inhibition of apoptosis to flies, and suggest that simil

269 cordingly, PI-3K is involved in TPO-mediated inhibition of apoptosis, TPO- and SDF-1-regulated adhesi

270 Furthermore, inhibition of apoptosis using the peptide caspase inhibi

271 ptide with cytoprotective effects, including inhibition of apoptosis via interaction with BCL-2 prote

272 The inhibition of apoptosis was associated with a decrease i

273 MKP-1-mediated inhibition of apoptosis was associated with decreased ph

274 Inhibition of apoptosis was associated with reduced indu

275 We hypothesized that TCDD-mediated inhibition of apoptosis was due to its ability to stimul

276 ng the ALPS-associated Fas mutants, dominant inhibition of apoptosis was much more pronounced in muta

277 Inhibition of apoptosis was observed in WT MEFs overexpr

278 ing Bcl2 and BclXL, in which 25- to 150-fold inhibition of apoptosis was observed.

279 GM-CSF-dependent inhibition of apoptosis was significantly attenuated by

280 Inhibition of apoptosis was temporary, because all the c

281 Moreover, both Akt phosphorylation and inhibition of apoptosis were abrogated by mutation of ty

282 anchorage-independent growth, as well as by inhibition of apoptosis, whereas the PDZ1 domain promote

283 tion/proteasomal destruction and synergistic inhibition of apoptosis, which is abolished in XIAP(-/-)

284 Interestingly, inhibition of apoptosis with a caspase 3 inhibitor also

285 The importance of H(2)O(2) was confirmed by inhibition of apoptosis with catalase.

286 Inhibition of apoptosis with cycloheximide inhibits the

287 Inhibition of apoptosis with the caspase inhibitor ZVAD.

288 ntion of tertiary lymphoid structures(1) and inhibition of apoptosis with tissue-regenerative strateg

289 The combined inhibition of apoptosis (with the pan-caspase inhibitor

290 hat targeting of Akt to the nucleus mediates inhibition of apoptosis without hypertrophic remodeling,

291 Inhibition of apoptosis would result in increasing accum