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1 neural activity, and alpha oscillations are inhibitory.
2 y state, we found that dopamine is primarily inhibitory.
3 report that papaverine, a vasodilator, shows inhibitory action against various strains of influenza v
4 as the most promising candidate with potent inhibitory activities against both PARP-1/2 and PI3Kalph
6 in olfactory processing by orchestrating OB inhibitory activities.SIGNIFICANCE STATEMENT Neuronal mo
7 unds that we previously showed to have broad inhibitory activity across multiple Clostridioides diffi
8 owed to be endowed with potent and selective inhibitory activity against the cancer-related human car
12 h atopic dermatitis (AD) affect the protease inhibitory activity of LEKTI or its susceptibility to me
14 emicarbazones (1-5): one of them revealed an inhibitory activity stronger than kojic acid, used as re
15 The EtOAc and MeOH extracts presented higher inhibitory activity with respect to alpha-amylase and ty
17 olerated substitutions without loss of RD3's inhibitory activity, substitutions in two distinct narro
18 alf of TIMP-1 is sufficient for TIMP-1's MMP-inhibitory activity, we propose that those C-terminal am
24 IGLEC gene number rather than those encoding inhibitory and activating subsets, suggesting that lifet
26 the presence of intestinal alpha-glucosidase inhibitory and augmenting cellular glucose uptake activi
27 transcriptional dynamics and disentangle its inhibitory and enhancing activities in transcription.
35 ion of T-cell polarizing cytokines or induce inhibitory antigen-presenting cells that suppress T-cell
37 tent analog was selected through an in vitro inhibitory assay to evaluate its pharmacokinetic paramet
42 s required for maintaining proper excitatory-inhibitory balance in the PFC and its control of behavio
43 owever, little is known about how excitatory-inhibitory balance is defined at most synapses or about
44 midal neurons, disrupt prefrontal excitatory-inhibitory balance, and alter processing of afferent inf
45 des three net negative charges appeared self-inhibitory because of ClC-5's voltage-gated properties,
48 stabilizes the interaction between the auto-inhibitory brace helix alpha6 and the four-helix bundle
50 o task, both IL and PL inactivation impaired inhibitory but not active reward-seeking, the latter eff
52 Here we investigated how excitatory and VIP inhibitory cells in layer 2/3 of mouse visual cortex wer
55 to characterize the role of immune cells and inhibitory checkpoints, genome-wide frequencies of copy
57 hese findings demonstrate how excitatory and inhibitory circuits interact to mediate an ethologically
59 yeast translation system to demonstrate that inhibitory codon pairs slow elongation rates which are p
60 eved by a network with reciprocal excitatory-inhibitory competitive dynamics, similar to interactions
61 t substrate of 40 kDa (PRAS40), an intrinsic inhibitory component of mTORC1, and prevented activation
63 showed a 60-fold lower shifted-half-maximal inhibitory concentration (IC(50)) for CYP4Z1 compared to
66 rains of Plasmodium falciparum (half maximal inhibitory concentration [IC50] = 1-2 uM), suggesting th
68 ing recombinantly expressed enzymes, minimum inhibitory concentration measurements, steady-state enzy
73 ounds inhibited M(pro), showing half-maximal inhibitory concentration values that ranged from 0.67 to
74 variants of the CXCR4 receptor (half-maximal inhibitory concentration, 8 nM [human]/2 nM [murine]) an
75 of two circular micropumps, and the minimum inhibitory concentrations (MIC) were then determined via
76 iotic mechanisms of action and resistance at inhibitory concentrations in the lab and in the clinic.
79 ened and L-theanine had a trend of worsening inhibitory control (i.e. increased Stop-signal reaction
80 nd their combination on sustained attention, inhibitory control and overall cognition in boys with at
81 eficial effects of acute aerobic exercise on inhibitory control are sustained for 60 min in children
83 l models of dACC function primarily focus on inhibitory control, highlighting surprise, choice diffic
86 Combining GDNF treatment with digestion of inhibitory CSPGs did not have a significant synergistic
87 neous and sensory-evoked swimming, the total inhibitory current was more than threefold larger than t
88 ly triggers prostaglandin E(2) release as an inhibitory DAMP to counterpoise the adjuvanticity of imm
89 -phase serum, with live-virus reciprocal 50% inhibitory dilution (ID(50)) geometric mean titers of 50
90 nteraction between its N-terminal diaphanous inhibitory domain (DID) and its C-terminal diaphanous au
91 memory discrimination and receives enhanced inhibitory drive from local cholecystokinin-expressing i
95 hanistic study shows a hitherto unrecognized inhibitory effect by the carboxylate anion on the cataly
98 6 and Y226 that is critical to transduce the inhibitory effect of Ca(2+) and the stimulatory effect o
99 0 mimetics significantly increase the growth inhibitory effect of chemotherapeutic agents in vitro an
100 We further show using KLF2 shRNA that the inhibitory effect of NMP on endothelial inflammation and
101 lysine residues are mutated to arginine, the inhibitory effect of RGFP966 on expansions is largely by
103 to the improved interfacial performance, the inhibitory effect of the antioxidants was remarkably pro
105 leaves them intact and thereby eliminates an inhibitory effect of TOMM34 on HSP70-mediated refolding
107 as the ethyl acetate extract had the highest inhibitory effect on heat-induced protein denaturation.
112 and (3) ultrasound can reversibly alter the inhibitory effects of tetrodotoxin (TTX) in pharmacologi
114 optotic activities but also presented strong inhibitory effects on cell mobility (migration and invas
117 a cell lines, and eight showed potent growth inhibitory effects with IC(50) values lower than 500 nM.
121 the versatile cytokine macrophage migration inhibitory factor (MIF) in regulating a metabolic rhythm
122 We also tested the ability of neonatal NET-inhibitory factor (nNIF) to block NET formation induced
124 newal of mESCs in combination with leukaemia inhibitory factor and regulates the formation of the mou
125 ative endogenous ligand macrophage migration inhibitory factor behaves opposite to CXCL12 in each ass
126 e neurons of the outer retina, which provide inhibitory feedback onto photoreceptors and contribute t
127 ggest that APs may play an important role in inhibitory feedback, and may have implications for under
134 dentify a novel role for NO in strengthening inhibitory GABA(A) receptor-mediated transmission in mol
135 glutamatergic synapses, MOC neurons receive inhibitory GABAergic and glycinergic synaptic inputs.
139 is the stromal ecology, which can be either inhibitory, highly reactive (supportive) or non-reactive
140 JH was described in 1934 as a "metamorphosis inhibitory hormone" in Rhodnius prolixus by Sir Vincent
143 acid (GABA) are the major excitatory (E) and inhibitory (I) neurotransmitters in the brain, respectiv
145 concentration correlated negatively with the inhibitory influence on the excitatory neuronal populati
146 ter environmental enrichment, differences in inhibitory innervation and ocular dominance plasticity b
147 of PNNs enwrapping PV+ cells regulates their inhibitory input and has a potent influence on their act
148 tability of mPFC->pPVT neurons and increased inhibitory input drive from low-threshold-spiking somato
149 onse is mediated by the S-ON pathway through inhibitory input from an undiscovered S-cone amacrine ce
152 nectivity, we built models of excitatory and inhibitory inputs onto a single neuron, to study how rec
153 ERCA) in cardiac myocytes is modulated by an inhibitory interaction with a transmembrane peptide, pho
154 gs provide a molecular basis for controlling inhibitory interneuron population size during circuit fo
159 rived from the dorsal telencephalon, whereas inhibitory interneurons are generated in its ventral por
161 orms of circuit motifs including reciprocal (inhibitory interneurons inhibiting other interneurons) a
162 ibiting other interneurons) and feedforward (inhibitory interneurons inhibiting principal neurons) co
164 ns (mEC LVa and LVb) as well as fast-spiking inhibitory interneurons receive direct excitatory input
165 Recent studies found that two most common inhibitory interneurons, parvalbumin- (PV) and somatosta
166 neurocircuits that encompass excitatory and inhibitory interneurons, similarly to those driven by se
167 Cortical areas comprise multiple types of inhibitory interneurons, with stereotypical connectivity
172 The GABA response switch from excitatory to inhibitory is a key event in neuronal maturation that de
173 PE) signals to trigger extinction, a type of inhibitory learning that is responsible for suppressing
179 insights into setron-binding poses and their inhibitory mechanisms are just beginning to emerge.
180 ir cognate transcription regulators, but the inhibitory mechanisms employed have thus far remained a
181 f sustaining repetitive activity, overcoming inhibitory mechanisms that restrict excitatory bursts, a
182 surface PVR, which interacts with TIGIT, an inhibitory molecule on CD8(+) effector memory T cells.
184 marizes recent data regarding the role of co-inhibitory molecules in the control of T(reg) cell funct
185 activase (Rca) regulates rubisco by removing inhibitory molecules such as ribulose-1,5-bisphosphate (
186 sought to characterize ARGX-117, a humanized inhibitory monoclonal antibody against complement C2.
187 the production by the developing cell of an inhibitory morphogen, but how this cell becomes immune t
192 of L1 interneurons participate in different inhibitory networks in superficial layers by targeting e
193 stic sensory input patterns, but that global inhibitory networks were unable to produce input-output
195 ies revealed diverse types of excitatory and inhibitory neuron in each circumventricular organ struct
196 e the RF selectively enhances excitatory and inhibitory neuron responses to task-irrelevant stimuli a
199 ether and how their expression changes in PV inhibitory neurons and excitatory neurons track with sen
200 y observations in the primary visual cortex: inhibitory neurons are broadly tuned in vivo and show no
202 te subpopulations of cortical excitatory and inhibitory neurons are significantly enriched for schizo
203 ory areas have elucidated that pyramidal and inhibitory neurons belonging to distinct layers show dis
204 ine firing rates (FRs) in GC with deep-layer inhibitory neurons displaying highest FRs at baseline an
205 A1 axons preferentially innervating specific inhibitory neurons in layer 1 and superficial layers.
207 is impairment appeared to critically involve inhibitory neurons in the auditory cortex called parvalb
208 novo translation in somatostatin-expressing inhibitory neurons in the centrolateral amygdala is nece
209 nslation in protein kinase Cdelta-expressing inhibitory neurons in the centrolateral amygdala is nece
210 ar terminals innervated excitatory relay and inhibitory neurons in the MDmc that facilitate faithful
211 nitor the activity of putative pyramidal and inhibitory neurons located in deep and superficial layer
212 expressing and somatostatin (SOM)-expressing inhibitory neurons modulate responses in mouse visual co
213 reveal that Lm128C cells are CaMKIIalpha(+) inhibitory neurons of parvalbumin or somatostatin subtyp
214 tracing to identify inputs to excitatory and inhibitory neurons of the intermediate and deep SC.
215 y neurons are driven by these large stimuli, inhibitory neurons that express parvalbumin and vasoacti
218 cortical circuitry and alterations in these inhibitory neurons, especially in the medial prefrontal
219 controlled by somatostatin-expressing (SOM) inhibitory neurons, which are excited by head movements
225 of excitatory neurotransmitter glutamate and inhibitory neurotransmitter GABA in regulating delay act
227 itive RGCs (ipRGCs) in mice that release the inhibitory neurotransmitter gamma-aminobutyric acid (GAB
229 ine whether a neurosteroid has potentiating, inhibitory, or competitive antagonist activity on GABA(A
230 rm synaptic plasticity (STP) profiles of the inhibitory parvalbumin (PV) and somatostatin (SST) inter
231 a lesser degree layer 4 neurons, as well as inhibitory parvalbumin-expressing interneurons (INs).
235 AEKTKIPAVF, IDALNENK, and VLVLDTDYK), DPP-IV-inhibitory peptides (LKALPMH, LKPTPEGDLEIL, LKGYGGVSLPE,
241 s and decreased the frequency of spontaneous inhibitory postsynaptic currents in the indirect pathway
242 cently demonstrated how these drugs modulate inhibitory postsynaptic signaling by direct binding to t
243 ed drugs for OATP2B1 inhibition and quantify inhibitory potencies necessary for extrapolation of clin
245 entification of compound 4 with desired FXIa inhibitory potency and good oral bioavailability but hig
252 ision (vLGN) connects subcortically, sending inhibitory projections to sensorimotor structures, inclu
253 ted network of long-range excitatory but not inhibitory projections with subtype-specific patterning.
255 expression and overexpression of complement inhibitory proteins on MM target cells as well as DARA-i
256 terns and significantly lower frequencies of inhibitory receptor expression, i.e., PD-1 and coexpress
257 control, CD4+ T cells quickly downregulated inhibitory receptors and differentiated into long-lived
258 e that balancing of immune responses through inhibitory receptors is an important quality control che
259 he tumor microenvironment (TME), blockade of inhibitory receptors that limit NK cell functions, and t
261 older mice (P40-P46), when ChC synapses are inhibitory, resulted instead in an increase in axo-axoni
262 ncoding RNA (lncRNA) that we named Stem Cell Inhibitory RNA Transcript (SCIRT), which was markedly up
263 e-catalyst mediated by the CB7 portal and an inhibitory role attributed to the lower interaction of t
264 pathogenic protein in SD weakened the normal inhibitory self-coupling of network hubs in both antero-
266 leep, with excited reward processing sending inhibitory signals to suppress noise in visual processin
267 dentified molecules that operate on both the inhibitory 'slender retainer' and activatory 'stumpy ind
268 BMP-2 induction leads to the expression of inhibitory Smad 6/7-dependent negative transcriptional r
274 tion of neuroligin-2, a key component of the inhibitory synapse, in the NAc that modifies behavioral
275 nduction of long-term plasticity at distinct inhibitory synapses and its regulation of hippocampal ne
276 c ephrin-B1 to influence both excitatory and inhibitory synapses during development can potentially c
279 ay involves crosstalk between excitatory and inhibitory synapses whereby Ca(2+)-entering through post
280 namic regulation of GABA(A)R accumulation at inhibitory synapses, thereby regulating the strength of
281 e and triggers an increase in the density of inhibitory synapses, which is accompanied by enhanced ax
283 y nerve and T-stellate cells, and made local inhibitory synaptic contacts on principal cells of the V
284 lthough little is known about stress-induced inhibitory synaptic plasticity and its relevance for neu
288 opioids induce a long-lasting suppression of inhibitory synaptic transmission onto OFC pyramidal neur
289 tissue damage induces long-term deficits in inhibitory synaptic transmission within the spinal super
291 ss, but they further indicate that sequences inhibitory to as well as supportive of Nef activity resi
292 tion would play a role in setting the spinal inhibitory tone and influencing sensory signaling, as sp
293 e findings suggest a common state of reduced inhibitory tone in the NAc in depression and stress susc
294 e and potentiate the synaptic excitatory and inhibitory tone onto mutant SF1 neurons, respectively.
296 r 1 (CB(1))-mediated long-term depression of inhibitory transmission (iLTD), a form of presynaptic pl
297 ex than expected interplay of excitatory and inhibitory transmitter systems in modulating working mem
298 s, an immature or impaired immune system and inhibitory tumor microenvironment can further complicate