ライフサイエンスコーパス: initiation

1 ng "when" it is important (i.e., at behavior initiation).

2 f open reading frames facilitate translation initiation.

3 ctin-membrane links is needed for protrusion initiation.

4 TR at median 6 months (range: 3-35) from HAI initiation.

5 e and months 1, 3, 6, and 12 after treatment initiation.

6 0.92) were associated with lower evaluation initiation.

7 rease reaction rate owing to faster catalyst initiation.

8 Initiation Factor 2 (IF2) during translation initiation.

9 or all-cause death within 48 weeks after ART initiation.

10 ustments (APAs) associated with delayed step initiation.

11 interaction is critical for DNA replication initiation.

12 a rare case of highly efficient near-cognate initiation.

13 reased spheroid formation, and delayed tumor initiation.

14 likely contribute to hyperplasia and cancer initiation.

15 a feedback mechanism increasing translation initiation.

16 l stiffness 2, 12, 24, and 42 weeks post-ART initiation.

17 or-nodes, which controls transfer competence initiation.

18 ommon at extracorporeal membrane oxygenation initiation.

19 witches is predicted to regulate translation initiation.

20 terize their molecular identities during bud initiation.

21 d to train participants to speed up movement initiation.

22 pathway, controlling the final step of cilia initiation.

23 rogression while being dispensable for tumor initiation.

24 r T2D who were eligible for statin treatment initiation.

25 linkage-to-care/antiretroviral therapy (ART) initiation (76%), HIV transmission (0.3-86.1/100PY, by H

26 nt for potential covariates, ages at alcohol initiation (AAIs) of 18.1-29.0 years, 29.1-39.0 years, a

27 iciently capture bidirectional transcription initiation across several human lymphoblastoid cell line

28 other proteins implicated in starch granule initiation allows us to propose how SS5 may act in this

29 ed between day 14 and day 42 after treatment initiation, although 80 genes were differentially expres

30 een 2010-2018, there were a total of 585 HCV initiations among 1130 eligible participants.

31 f the neural interaction underlying movement-initiation and -cancellation, opening new avenues for th

32 e context of its role in selective autophagy initiation and autophagosome formation.

33 we deepen our understanding of breast cancer initiation and begin developing and testing novel preven

34 h sites are important for polymerase de novo initiation and elongation activities and essential for v

35 The process of transcription initiation and elongation are primary points of control

36 ases, tRNA-modification enzymes, translation-initiation and elongation factors, and ribosomal protein

37 , we found that Xrn1 modulates transcription initiation and elongation of its target genes.

38 tive control: a unimanual task involving the initiation and inhibition of a single response, and a bi

39 ism of NSP2-mediated viroplasm/lipid droplet initiation and interaction will lead to new insights int

40 s is now recognized as indispensable for the initiation and maintenance of chronic pain.

41 ioned stimuli exert a major influence on the initiation and maintenance of drug seeking often long in

42 tensively investigated, our knowledge of the initiation and maintenance of EGFR signaling during cell

43 those at the nerve injury site, to both the initiation and maintenance of the mechanical hypersensit

44 hypothalamus (LH), which regulate REM sleep initiation and maintenance.

45 erate with HER2/neu to enhance breast cancer initiation and metastasis, despite having no effect on p

46 p1-60S binding is highest during start codon initiation and N-terminal peptide elongation, regulating

47 tion and function of prokaryotic translation initiation and other RNA-mediated processes.

48 cterization of metabolic changes after INSTI initiation and potential therapeutic interventions are n

49 lations, which limits the studies of meiosis initiation and progression at a higher resolution level.

50 h offers new information not only on meiosis initiation and progression but also on screening pathoge

51 results from distinct biological and disease initiation and progression events associated with Chr1-

52 metabolic reprogramming occurs during tumour initiation and progression in renal cell carcinoma (RCC)

53 naling has also been associated with disease initiation and progression in the gastrointestinal (GI)

54 with tumour and stromal cells to promote the initiation and progression of a variety of solid and hae

55 The factors implicated in the initiation and progression of tau misfolding and aggrega

56 oblast specific upregulation of IGF-1 in the initiation and progression of TGFbeta-induced fibrogenes

57 ysregulated metabolism contributes to cancer initiation and progression, but the key drivers of these

58 ervous system plays an active role in cancer initiation and progression.

59 ulatory circuit that is beneficial for tumor initiation and progression.

60 echanisms through which t-ASPP2 promotes ILC initiation and progression.

61 etion of eIF5A or Tsc2 leads to metabolic re-initiation and proliferation, but at the expense of incu

62 gration occurs via capillary invasion and/or initiation and propagation of fractures (Fig.

63 es (LOOH) formation and decomposition during initiation and propagation peroxidations.

64 The reversibility of the redox-mediated initiation and propagation steps enable spatiotemporal c

65 ersible dislocation motion followed by crack initiation and propagation.

66 eIF2 recycling, thereby halting translation initiation and reducing global protein synthesis.

67 ls (hybrid approach); or standard clinic ART initiation and refills.

68 PFL2 signaling module evolved to control the initiation and regular, equidistant spacing of ovule pri

69 Macrophages are central to initiation and resolution of inflammation and developmen

70 n of D2Rs on iMSNs resulted in slower action initiation and response rate in an instrumental conditio

71 in specific misregulation of the translation initiation and ribosome biogenesis machinery.

72 Auxin-induced root hair initiation and ROS accumulation were reduced in an rbohc

73 post-transcriptional processing, translation initiation and stability.

74 etween sensorimotor beta bursts and movement initiation and suggest that neurofeedback training could

75 d their inhibition, as well as transcription initiation and transcription factors, have detailed the

76 TCT initiation is intertwined with canonical initiation and used divergently in hundreds of dual-init

77 ses, higher BMI was associated with dialysis initiation and with venous thromboembolism but not with

78 ease with LPs and blood cultures, prompt ART initiation, and more intensive antifungals may reduce mo

79 The mechanistic basis of seizure initiation, and the contribution of defined neuronal sub

80 nd clinical variables, including time to ART initiation, and the proportion of participants with a co

81 VL) early after antiretroviral therapy (ART) initiation appears frequently in pregnant and postpartum

82 D is estimated at 70-80% and of cannabis use initiation at 40-48%.

83 work in Leishmania detected DNA replication initiation at just a single region in each chromosome, a

84 ing and ART refills through mobile vans; ART initiation at the clinic followed by mobile van monitori

85 n channel complexes promote action potential initiation at the mammalian axon initial segment (AIS),

86 imply that the effect of baseline BMI, HAART initiation, baseline viral load, and the number of sexua

87 ed by cMYC, a response that blunts carcinoma initiation, but does not perturb the normal pregnancy-in

88 Modulation of the fidelity of translation initiation by OCM opens new avenues to understand altern

89 anscription factor facilitates transcription initiation by opening the DNA strands around the transcr

90 a link between sensing of peripheral cancer initiation by the bone marrow and hematopoietic adaptati

91 In the partially melted initiation complex (PmIC), transcription factor MTF1 mak

92 IF4E, the mRNA 5' cap-binding protein of the initiation complex and binding partner of eIF4G1.

93 IF4E, the mRNA 5'-cap binding protein of the initiation complex and binding partner of eIF4G1.

94 study, we determined a series of transcript initiation complex structures from the pyrG promoter usi

95 F4G for eIF4E binding within the translation initiation complex.

96 on and prevents formation of the translation initiation complex.

97 +1 nucleosome suggests that a transcription-initiation dependent process could contribute to its spe

98 and viral DNA in these animals prior to ART initiation, during ART suppression, and following viral

99 m of over a dozen factors that govern Pol II initiation (e.g., TFIID, TFIIH, and Mediator), pausing,

100 fusion with the 100 bp minimum transcription initiation element (TIE) of Klk1b21, suggesting that the

101 e, require the translation initiation factor initiation elongation factor alpha (eIF2alpha).

102 the many proteins involved in transcription initiation, elongation, and termination, several noncodi

103 ts before successful diagnosis and treatment initiation, especially in the private sector.

104 phase of translation, thus blocking further initiation events.

105 thesis via phosphorylation of the eukaryotic initiation factor (eIF) 2alpha and thereby induce the IS

106 llosteric activation of the essential GTPase Initiation Factor 2 (IF2) during translation initiation.

107 ) that phosphorylates eukaryotic translation initiation factor 2 alpha (eIF2alpha), which orchestrate

108 R, phosphorylation of eukaryotic translation initiation factor 2 subunit 1 (eIF2alpha), the SG assemb

109 cally reducing phosphorylation of eukaryotic initiation factor 2alpha in excitatory neurons in the LA

110 ble polymerization of eukaryotic translation initiation factor 2B, an essential enzyme in the initiat

111 Eukaryotic initiation factor 4A (eIF4A), an ATP-dependent DEAD-box

112 factors involved in 40S scanning (eukaryotic initiation factor 4A [eIF4A], eIF4B, and Ded1), indicati

113 The eukaryotic translation initiation factor 4E (EIF-4E) protein, a key regulator o

114 its interactions with eukaryotic translation initiation factor 4E, and resists decapping.

115 expression levels of eukaryotic translation initiation factor 4GI (eIF4GI) and of its homolog, death

116 nce and strict requirement of the additional initiation factor Bdp1 in the RNA polymerase (RNAP) III

117 tion stage by competing with the cap-binding initiation factor complex, eIF4F, restricting infection

118 is of proteins controlled by the translation initiation factor eIF2(11).

119 pported by the localization of a translation initiation factor eIF4E and by ribosome-bound nascent ch

120 therapy resistance, require the translation initiation factor initiation elongation factor alpha (eI

121 alpha (P-eIF2alpha), a conserved translation initiation factor, is clock controlled in Neurospora cra

122 onents, RNA association was most reduced for initiation factors involved in 40S scanning (eukaryotic

123 f1 and TFB2M proteins serve as transcription initiation factors of mitochondrial RNA polymerases in S

124 uron-specific microexon in eIF4G translation initiation factors that dampens synaptic protein transla

125 We described the relative timings of sexual initiation, first union (cohabitation or marriage), and

126 f nucleosomes with most genomic DNA prevents initiation from cryptic promoters.

127 lessness after cardiopulmonary resuscitation initiation had lower intra-arrest hemodynamics and worse

128 taxis, flower morphogenesis, or lateral root initiation, have been extensively studied, and genes con

129 o important health benefits of immediate ART initiation; however, the policy's impact on the economic

130 lonal expansion of cells infected before ART initiation.IMPORTANCE There are limited data about the p

131 is matter through the temporal regulation of initiation in a living coordination-insertion polymeriza

132 ES43 was antagonistic to BdFTL2 in flowering initiation in a transcription-dependent manner and signi

133 tion, and lung injury prior to and after ART initiation in adults with HIV and pulmonary TB.

134 egulate the fidelity and rate of translation initiation in bacteria and eukaryotic organelles such as

135 Mechanistic studies of transcription initiation in bacteria are especially amenable because t

136 by Np(4)N incorporation during transcription initiation in bacterial cells.

137 sm for how surface sensing drives cell-cycle initiation in Caulobacter crescentus We identify the typ

138 cortex before the go-cue and slowed movement initiation in healthy motor control.

139 IV DNA are determined around the time of ART initiation in individuals treated during PHI.

140 ible to study mechanisms of disease risk and initiation in otherwise inaccessible patient-specific ce

141 ave detailed the mechanisms of transcription initiation in phylogenetically diverse bacteria, inspiri

142 There was no association with ART initiation in the hospital and retention in HIV care and

143 rt of nematode reproduction and colonization initiation in the infective juvenile (IJ) stage nematode

144 BRs also participate in the control of ovule initiation in tomato, by promoting an increase on ovule

145 tion of the PIC to influence the accuracy of initiation in vivo.

146 We report structures of two transcription initiation intermediate states of yeast mtRNAP that expl

147 Voluntary movement initiation involves the modulations of large groups of n

148 Therefore, transcription initiation involving sigma(54) differs from other bacter

149 Initiation is a rate-limiting step in cap-dependent tran

150 Movement initiation is characterized by steady reductions of beta

151 We find that every day ART initiation is delayed results in a 39% increase in the r

152 In G0 cells, canonical translation initiation is inhibited; yet we find that inflammatory g

153 5'-TOP/TCT initiation is intertwined with canonical initiation and

154 These findings argue that re-initiation is not a major mechanism of translational cou

155 ms a substrate for re-entry while arrhythmia initiation is often associated with sympathetic activati

156 However, leaf initiation is slower and there is no change in shoot bra

157 one role for phasic DLS activity at behavior initiation is to promote the execution of the behavior i

158 s promote tissue ingrowth, which upon cancer initiation is transformed into a metastatic niche that c

159 Most intriguingly, depending on the initiation kinetics, stochastic elongation can either en

160 ustly detects small changes in budding yeast initiation kinetics, which could not be resolved by bulk

161 rucial transitions in cancer-including tumor initiation, local expansion, metastasis, and therapeutic

162 olecular mechanisms presumed to drive tumour initiation, maintenance and recurrence across individual

163 ie's hypothesis of a growth-rate-independent initiation mass(4).

164 strategies, we characterized the translation initiation mechanism of MCMV.

165 lts suggest the need to refine PSB and crack-initiation models in metals to account for gradual and h

166 Cdc15 mobility is dependent on the septation initiation network (SIN).

167 ciated factors such as GATA3, which suggests initiation of a TE program.

168 trial compared neoadjuvant versus concurrent initiation of ADT in combination with dose-escalated pro

169 hypothesise that the winner-loser effect on initiation of agonistic behaviour (display, non-damaging

170 o HCV-negative recipients, followed by early initiation of an 8-week regimen of glecaprevir and pibre

171 o activation of allergic-skewing DCs and the initiation of an allergic immune response.

172 and 365 days after catheter ablation or the initiation of an antiarrhythmic drug.

173 While a rational strategy for initiation of an economic reboot would call for a wider

174 both EPTB and pulmonary TB (PTB) and timely initiation of anti-TB therapy.

175 o reconstitute their CD4 + T cell pool after initiation of antiretroviral therapy, and their prognosi

176 on of reactive oxygen species (ROS), and the initiation of apoptosis.

177 and <500 cells/mm3 thereafter) to the 'Early Initiation of ART for All' (EAAA) intervention at one of

178 Hazard ratios (HRs) of CVD < 1 year after initiation of BEP treatment were as follows: myocardial

179 Moreover, a lack of serine results in the initiation of biofilm formation.

180 chromosomal amplification contributes to the initiation of cancer by mediating overexpression of onco

181 ollectively referred to as rhizobia, and the initiation of cell divisions in the root cortex.

182 These findings have led to the initiation of clinical trials using approved drugs that

183 hnology-based drugs are essential to support initiation of clinical trials.

184 was one of the first countries to recommend initiation of combination antiretroviral therapy (cART)

185 his remains the case in the setting of early initiation of combination antiretroviral therapy (cART),

186 Mf clearance occurred within 2 days of initiation of DEC in all 7 mf-positive subjects.

187 hat induced pathogenic CD4(+) T cells at the initiation of diabetes derived from proinsulin.

188 004) and with a higher incidence of death or initiation of dialysis (hazard ratio, 1.48; 95% CI, 1.04

189 (EGA) <= 32 weeks, and <30 days old prior to initiation of enteral feeding.

190 hopaedic trauma must be allowed prior to the initiation of exercise to achieve optimal pain, function

191 Following the initiation of extracorporeal carbon dioxide removal, blo

192 e-suppressing signals, which discourages the initiation of feeding and drinking (fully recapitulating

193 Finally, LPI promoted the initiation of hepatic stellate cell activation by stimul

194 Late initiation of HIV antiretroviral therapy (ART) in pregna

195 HELLS promotes initiation of HR by facilitating end-resection and accum

196 almic immune-related AEs within 1 year after initiation of ICI therapy was determined.

197 ial role in the recognition of pathogens and initiation of immune responses(1-3).

198 The initiation of intracellular host cell colonization by sy

199 roper root clock function and the subsequent initiation of lateral root primordia.

200 icrobiome was unchanged among subjects after initiation of legume supplementation.

201 f motor complications arising from the early initiation of levodopa, which led to misconceived levodo

202 and reveals an impact of cellular status on initiation of lineage plasticity.

203 screening for obstructive sleep apnea before initiation of long-term NIV (conditional recommendation,

204 progression by a >=50% decline in the eGFR, initiation of maintenance dialysis, or kidney transplant

205 mechanism for the preoptic DA neurons in the initiation of movement.

206 The initiation of MSCI is required for stage progression, wh

207 The mechanism of initiation of neuroinflammation during SAE, which ultima

208 Five months after initiation of nivolumab treatment, the first follow-up c

209 tensively studied, and genes controlling the initiation of ovules have been identified.

210 ogenetic activation of the epithelium showed initiation of pain-like responses.

211 ironmental factor that may contribute to the initiation of pancreatic beta-cell destruction during th

212 they are poised for expression prior to the initiation of pluripotency transition to the formative s

213 from high-achieving centers to promote early initiation of prenatal care among medically vulnerable a

214 e preclinical evidence is now leading to the initiation of proof-of-concept clinical trials using sen

215 ounseling and subsequent early diagnosis and initiation of proper therapy.

216 iation factor 2B, an essential enzyme in the initiation of protein synthesis, into large bundles of f

217 sufficient to delay prostate and skin cancer initiation of Pten-deficient mice.

218 Initiation of pulmonary rehabilitation within 90 days of

219 the protrusive behavior required during the initiation of radial intercalation.

220 tacles to attract re-entry, facilitating the initiation of re-entrant circuits.

221 enome replication in transfected cells, with initiation of replication from the upstream genome copy.

222 The initiation of RNA interference (RNAi) by topically appli

223 ative priming loop that is important for the initiation of RNA synthesis is fully retracted, which le

224 ce at postnatal day 0 (PN0), just before the initiation of root morphogenesis.

225 cute Heart Failure Episode), the in-hospital initiation of sacubitril/valsartan in patients hospitali

226 ated wave between E12.5 and E14.5 before the initiation of sensory receptor cell differentiation, mak

227 graded following binding to its receptor and initiation of signaling.

228 Here we present the initiation of the Archaeal Proteome Project (ArcPP), a c

229 ells were thought to be a pivotal factor for initiation of the autoimmune blistering disease pemphigu

230 lationally, these findings are predictive of initiation of the prodromal / preclinical phase of LOAD

231 echanism for this defect is the uncontrolled initiation of the unfolded protein stress response, with

232 went a second (18)F-FGln study 4-13 wk after initiation of therapy with glutaminase, dual TORC1/2, or

233 so a marker of immune activation early after initiation of therapy with PD1-blocking antibodies and p

234 eral ARN showed fellow-eye involvement after initiation of therapy.

235 f total IgG in B6 mice possibly suggests the initiation of TLR3-dependent pathway early during P. yoe

236 At the initiation of tracheal development, endoderm begins to e

237 tion and dispersal of BTV coincided with the initiation of transcontinental livestock trade after the

238 However, the size of the benefit of earlier initiation of treatment and the overall cost-effectivene

239 F therapy, most often observed shortly after initiation of treatment.

240 clease, an essential protein involved in the initiation of viral transcription by cleaving capped mRN

241 tically significant but small effects on the initiation of volitional movements and no discernable ef

242 SPEN acts as a molecular integrator for the initiation of XCI, bridging Xist RNA with the transcript

243 We propose that dual-initiation on shared promoters represents a composite pr

244 t of very early antiretroviral therapy (ART) initiation on the rate of recrudescence and the viral lo

245 brassinosteroids, and light to result in AM initiation only in the axils of leaves at a certain age.

246 tro response to vedolizumab before treatment initiation or dynamic integrin regulation in the early c

247 tivation of all neuronal classes but not the initiation or maintenance of the seizure.

248 Flexible initiation or suppression of actions to avoid aversive e

249 ated with greater likelihood of hospital ART initiation (p=0.008).

250 mitochondrial dysfunction, and transcription initiation pathways with direct fixation.

251 Translational control targeting the initiation phase is central to the regulation of gene ex

252 polymerase assays identified a block in the initiation phase of the viral polymerase.

253 y LOOH formations during the propagation and initiation phases, respectively.

254 dered the situation in 2018 and compared ART initiation policies of an efavirenz-based regimen in wom

255 proteins have been implicated in the granule initiation process in Arabidopsis (Arabidopsis thaliana)

256 te to haematological disease predisposition, initiation, progression and response to therapy into fut

257 ng') is key to understanding the prevention, initiation, progression and response to treatment of can

258 ctional signaling modulator, promotes cancer initiation, progression, and metastasis by regulating ce

259 tal platform allows the study of human tumor initiation, progression, manifestation, and tumor-immune

260 indings link H2A.Z eviction to transcription initiation, promoter escape and early elongation activit

261 Dual-initiation promoters are pervasive in human and fruit fl

262 ion and used divergently in hundreds of dual-initiation promoters during maternal to zygotic transiti

263 ssion or function of the plasmid replication initiation protein, RepE.

264 Before ART initiation, PTCs had higher CD4 T cell counts, lower pla

265 restrictions on hepatitis C (HCV) treatment initiation rates among people living with human immunode

266 TF) binding regions and at the flanking eRNA initiation regions, both of which are associated with mR

267 y due to high occupancy of the transcription initiation/repair factor TFIIH in this nucleosome.

268 over time since linkage with respect to ART initiation, retention in care, transfers, and mortality.

269 uggest that underlying disease and timing of initiation should be carefully considered before startin

270 pression of beta bursts to speed up movement initiation.SIGNIFICANCE STATEMENT This double-blind sham

271 hanges upstream of the site of transcription initiation similarly affect both the efficiency with whi

272 logy to mutate a single internal translation initiation site in Cx43 (M213L mutation), which generate

273 g11 concentrates Atg32 to generate mitophagy initiation sites.

274 mRNAs produced via alternative transcription initiation sites.

275 IFIT1 inhibits translation at the initiation stage by competing with the cap-binding initi

276 (stage D; primary analysis) and ARNI therapy initiation (stage C; matched reference).

277 Most commonly, LRP initiation starts with the specification of just one FC

278 A hallmark of the initiation step of HIV-1 reverse transcription, in which

279 produced during early steps in transcription initiation stimulate condensate formation, whereas the b

280 dose and time dependent in suppressing tumor initiation suggesting prolonged mammary exposure may imp

281 The dynamic landscape of transcription initiation suggests a kinetically driven regulation of m

282 or replisome assembly during DNA replication initiation that is vulnerable to inhibition as combinati

283 Mechanisms of regulation at each step, from initiation to elongation dynamics, produce qualitatively

284 nt in Drosophila to quantify production from initiation to homeostasis.

285 nvironment before or shortly after treatment initiation to identify predictive biomarkers differentia

286 icipants with HIV (CD4 < 50 cells/uL) at ART initiation to receive either empiric TB treatment or iso

287 ts binding site prior to the transition from initiation to the elongation phase of translation, thus

288 gnosed, were eligible and ready for same-day initiation under the SLATE II algorithm.

289 demographic characteristics and time to ART initiation using Cox proportional hazard models, and, in

290 redict death within 120 days after treatment initiation using time-updated data during the first 30 d

291 Timely initiation varied by geography and qualifying event type

292 t that couples surface contact to cell-cycle initiation via the second messenger cyclic di-GMP (c-di-

293 Median age at dialysis initiation was 64 years, 45% were female, 32% were Black

294 (PFS) and median overall survival after BTKi initiation were 34 months (range, <1 to 49) and 42 month

295 paring the risk-adjusted effect of treatment initiation with bevacizumab versus ranibizumab (hazard r

296 Treatment initiation with integrase strand transfer inhibitors (IN

297 or all-cause hospitalization after treatment initiation with intravitreal bevacizumab, ranibizumab, o

298 tacrolimus dose was mandatory upon treatment initiation with letermovir.

299 mobile phone software to community-based ART initiation with quarterly monitoring and ART refills thr

300 Children <18 years at ART initiation, with sustained viral suppression (VS) (<=400