ライフサイエンスコーパス: initiation complex

1 at IRES motifs on mRNA by the translational initiation complex.

2 nd the Unc-51-like kinase 1 (ULK1) autophagy initiation complex.

3 lin and Atg14, constituents of the autophagy initiation complex.

4 ich then recruits EBNA2 to the transcription initiation complex.

5 n 1, an essential component of the autophagy initiation complex.

6 e RbpA-SID in the context of a transcription initiation complex.

7 dock and the TFIIB ribbon and stabilizes the initiation complex.

8 ent signaling through the ULK1 autophagy pre-initiation complex.

9 involvement in positioning components of the initiation complex.

10 iption bubble to stabilize the transcription initiation complex.

11 unwinding and the assembly of a replication initiation complex.

12 hways on the way to the formation of the pre-initiation complex.

13 es promoter melting and formation of an open initiation complex.

14 merase resulting in the formation of the pre-initiation complex.

15 nd these factors during formation of the pre-initiation complex.

16 of the entire mitochondrial transcriptional initiation complex.

17 scaffold that enables formation of the full initiation complex.

18 the binding of eIF4B to the eIF3 translation initiation complex.

19 itiator methionyl transfer RNA to form a 48S initiation complex.

20 n miRNAs impairing the function of the eIF4F initiation complex.

21 on and prevents formation of the translation initiation complex.

22 bilizing the overall conformation of the 80S initiation complex.

23 neighbouring AAA+ domains to form an active initiation complex.

24 kely impede subsequent assembly into the pre-initiation complex.

25 s, P7 may promote assembly by stabilizing an initiation complex.

26 selection before the formation of stable pre-initiation complex.

27 portant for the formation of the translation initiation complex.

28 e a structural model of the T4 late promoter initiation complex.

29 romoter is required to assemble a functional initiation complex.

30 ernary complex within the ribosome-bound pre-initiation complex.

31 factor TFIID, the major component of the pre-initiation complex.

32 n scanning beyond loading eIF4A onto the pre-initiation complex.

33 ar the predicted path of upstream DNA in the initiation complex.

34 F4G for eIF4E binding within the translation initiation complex.

35 iving assembly of the Leishmania translation initiation complex.

36 the accurate formation of the transcription initiation complex.

37 defective in producing replication-competent initiation complexes.

38 conservation of human Pol II and Pol III pre-initiation complexes.

39 imiting helicase-activation factors into pre-initiation complexes.

40 ly thus governing the formation of autophagy initiation complexes.

41 cetylation and assembly of RNA Polymerase II initiation complexes.

42 nd aid in specific assembly of transcription initiation complexes.

43 d for 11 and 15 on corresponding replication initiation complexes.

44 and promote recruitment of ribosomal 43S pre-initiation complexes.

45 *PABP complexes competent to recruit 43S pre-initiation complexes.

46 echanistic sense for formation of functional initiation complexes.

47 are important constituents of all eukaryotic initiation complexes.

48 nd its interactions within transcription pre-initiation complexes.

49 48S initiation complex (48S IC) formation is the first stage

50 nsition from a closed to an open Pol III pre-initiation complex, a process dependent on the activity

51 licase, a component of the eIF4F translation initiation complex, abrogates this selectively increased

52 identify approximately 160,000 transcription initiation complexes across the human K562 genome, and m

53 of the pathogen activates the host autophagy initiation complex (AIC) and the upstream regulatory com

54 n element (CRE) that stabilize transcription initiation complexes also occur in transcription elongat

55 IF4E, the mRNA 5'-cap binding protein of the initiation complex and binding partner of eIF4G1.

56 IF4E, the mRNA 5' cap-binding protein of the initiation complex and binding partner of eIF4G1.

57 57 associates with components of the 48S pre-initiation complex and co-sediments with the 40S ribosom

58 upstream relocation of the transcription pre-initiation complex and ectopic transcription initiation.

59 modulate transcription by associating to the initiation complex and increasing the flux of transcript

60 TFS4 destabilises the TBP-TFB-RNAP pre-initiation complex and inhibits transcription initiation

61 n of a catalytically competent transcription initiation complex and remains closed during initial tra

62 to locate the initiation codon, form the 80S initiation complex and start protein synthesis.

63 ions the initiator tRNA on the 30S ribosomal initiation complex and stimulates its assembly to the 50

64 catalytically competent conformation of the initiation complex and that establishment of contacts be

65 romoter DNA to stabilize both the closed pre-initiation complex and the open-promoter complex, and to

66 hat interacts first with TFIID in the Pol II initiation complex and then exchanges TFIID for complexe

67 sts, Mer2 mediates assembly of recombination-initiation complexes and double-strand breaks (DSBs).

68 that are condensates of stalled translation initiation complexes and mRNAs.

69 olecular aggregates that contain translation initiation complexes and mRNAs.

70 A in front of the active site that stabilize initiation complexes and persist throughout elongation.

71 Loss of ELL destabilizes the pre-initiation complexes and results in disruption of early

72 We determined that translation initiation complexes and ribosomes purified from transla

73 03E polymerase (Pol) III alpha that can form initiation complexes and sequester primer termini but no

74 ted to 5S rRNA genes as a part of proficient initiation complexes and the activity persists at reinit

75 p closure accounts for the high stability of initiation complexes and the high stability and processi

76 I) involves the formation of a transcription initiation complex, and a transition to an elongation co

77 he 40S subunit as a component of the 43S pre-initiation complex, and comparison of the ribosomal posi

78 4B), increased its assembly into translation initiation complex, and subsequently facilitated protein

79 ion in Eif3c, a component of the translation initiation complex, and that the phenotype is associated

80 granules, which contain stalled translation initiation complexes, and processing bodies (P bodies),

81 rk can promote remodeling of the translation initiation complexes, and the roles in the process playe

82 Lectin pathway initiation complexes are composed of multimolecular carb

83 son of their ability to support formation of initiation complexes, as measured by processive replicat

84 onal pseudo-atomic model for a DNA-packaging initiation complex assembled from the terminase small su

85 regation of RNA polymerase II-containing pre-initiation complexes assembled next to each other in the

86 uctures of human mitochondrial transcription initiation complexes assembled on both light and heavy s

87 II genes, suggesting multiple rounds of pre-initiation complex assembly and disassembly before produ

88 n protein synthesis by enhancing translation initiation complex assembly at the 5' mRNA cap and an in

89 roteins needed for transcription activation, initiation complex assembly, and productive elongation.

90 ls insights into early events of translation initiation complex assembly, as well as how eIF4F intera

91 hibition of mTOR or Pim kinases, translation initiation complex assembly, or eIF4A function.

92 a loss of DNA packaging and an impairment of initiation complex assembly.

93 y, we determined a structure of a transcript initiation complex at the pyrBI promoter and proposed an

94 Formation of initiation complexes at 5'-terminal AUGs was stimulated

95 Biochemical analysis of ribosomal initiation complexes at CUG versus AUG initiation codons

96 Using the antibiotic retapamulin to trap initiation complexes at start codons, we find that the m

97 The eukaryotic 43S pre-initiation complex bearing tRNAi(Met) scans the mRNA lea

98 factors, which must dissociate from the 30S initiation complex before the resulting 70S elongation-c

99 reaction: the ATP-dependent formation of an initiation complex between the Pol III HE and primed DNA

100 w that the primosome in this stable helicase initiation complex binds the DNA of the fork primarily v

101 ompete with wild-type Pol III alpha and form initiation complexes, but cannot elongate.

102 active ATP binding site is required to form initiation complexes, but the two additional sites incre

103 Genetic blockade of the translation initiation complex by eIF4E knockdown or expression of a

104 ion of catalytically competent transcription initiation complex by measuring initiation activity of s

105 ockdown of RNase P abolishes the assembly of initiation complexes by preventing the formation of the

106 the extrinsic tissue factor (TF) coagulation initiation complex can selectively activate the antihemo

107 pen-promoter complex, and to regulate start--initiation complexes, combined with the localization of

108 ought to serve as a platform to assemble pre-initiation complexes competent for transcription.

109 es it interfere with eIF2 binding to 43S pre-initiation complex components.

110 3.0 A resolution of functional transcription initiation complexes comprising Thermus thermophilus RNA

111 rmational rearrangement of the RepD-PcrA-ATP initiation complex confines it strictly within the bound

112 osphorylation of the kinase SYK, the calcium initiation complex consisting of BLNK, BTK, and PLCgamma

113 P system to probe the archaeal transcription initiation complex, consisting of promoter DNA, TBP, TFB

114 polymerase binds to promoter DNA to form an initiation complex containing a DNA bubble and enters in

115 ly controlled process that includes an early initiation complex containing eukaryotic initiation fact

116 rrent DNA replication, is accomplished by an initiation complex containing the host RNA polymerase as

117 ediate membranes and show that the autophagy-initiation complex containing ULK and FIP200 first assoc

118 crystal structures of E. coli transcription initiation complexes containing a complete transcription

119 crystal structures of Thermus transcription initiation complexes containing CarD.

120 e report crystal structures of transcription initiation complexes containing Mycobacterium tuberculos

121 major scaffolding protein in the translation initiation complex, directly binds G4s and this activity

122 tants for the binding of 50S subunits to 30S initiation complexes during initiation and for their rel

123 , and one of the six cap-binding translation initiation complexes, EIF4E6-EIF4G5.

124 E, an essential component of the translation initiation complex eIF4F, is downregulated by binding th

125 el of a requisite scaffolding protein of the initiation complex, eIF4G1, downstream of nutrients and

126 el of a requisite scaffolding protein of the initiation complex, eIF4G1, downstream of nutrients and

127 The plant-specific translation initiation complex eIFiso4F is encoded by three genes in

128 Initiation complexes exhibit a half-life of dissociation

129 ymerase to the newly loaded clamp to form an initiation complex for processive replication.

130 located in similar positions to those of the initiation complex for the hepatitis C virus polymerase.

131 35, precluding the assembly of transcription initiation complexes for rDNA.

132 lex provides a molecular explanation for how initiation complexes form when supported by the nonhydro

133 targeting at least two separate stages: 48S initiation complex formation and the steps involved in t

134 ATP analogue ATPgammaS was found to support initiation complex formation at 1/1000th the rate with A

135 , eIF3, eIF1 and eIF1A promote efficient 48S initiation complex formation at AUG828, which is reduced

136 -mediated polymerase chaperoning accelerates initiation complex formation by 100-fold.

137 osed ATPgammaS drives hydrolysis-independent initiation complex formation by tau-containing complexes

138 ntracellular signal transduction and dynamic initiation complex formation coordinated by flexible eIF

139 Interestingly, DHX29 impedes the 48S initiation complex formation in the absence of eIF1A per

140 articipation of i-tRNA in the first round of initiation complex formation licenses the final steps of

141 However, IF3(mt) stimulates initiation complex formation on leaderless mRNAs when te

142 lysis of three ATPs dramatically accelerates initiation complex formation to a rate constant (25-50 s

143 The kinetics of initiation complex formation were explored for DnaX comp

144 t although one ATPase site is sufficient for initiation complex formation, the combination of polymer

145 cell extracts, if this precedes the stage of initiation complex formation.

146 secondary mutations that were ineffective in initiation complex formation.

147 omoter that facilitate efficient de novo pre-initiation complex formation.

148 the core RNA polymerase and thereby promotes initiation complex formation.

149 the polymerase to promoter-bound SL1 in pre-initiation complex formation.

150 in the rDNA-promoter region and reduced pre-initiation complex formation.

151 -dependent, inhibitory effect on 48S and 80S initiation complex formation.

152 A compaction and transcriptional activity on initiation complex formation.

153 ATPgammaS hydrolysis coincide with those for initiation complex formation.

154 nd by chromatin modifications to promote pre-initiation complex formation.

155 the role of Bdp1 in TFIIIB assembly and pre-initiation complex formation.

156 Transcription initiation complexes formed by bacterial RNA polymerases

157 Initiation complexes formed even at the very 5' end of m

158 imolecular aggregates of stalled translation initiation complexes formed to aid cell recovery.

159 e steps involved in the formation of the 80S initiation complex from the 48S complex.

160 he structures of the 30S(2-5) and 70S(4,6-8) initiation complexes have revealed that the ribosome, in

161 end of messenger RNA (mRNA) to form the 48S initiation complex (i.e., the 48S).

162 subunit to the small, 30S, ribosomal subunit initiation complex (IC) during bacterial translation ini

163 ation initiation factor 2 (IF2) promotes 30S initiation complex (IC) formation and 50S subunit joinin

164 actors (IFs) regulate association of the 30S initiation complex (IC) with the 50S subunit to control

165 In the initiation complex (IC), the template in the expanded 7-

166 of interaction between the components of the initiation complex (IC).

167 romotes the 60S subunit joining with the 40S initiation complex (IC).

168 ly released on conversion of 48S PICs to 80S initiation complexes (ICs) and this abnormality and rela

169 rate of 50S ribosomal subunit joining to 30S initiation complexes (ICs) that carry an N-formyl-methio

170 Profiling 40S initiation complexes in ded1 and dbp1 mutants provides d

171 es, using the cap analog m7GTP to enrich for initiation complexes in glioma cells followed by mass sp

172 ed single, surface-immobilized vRNA and cRNA initiation complexes in real-time.

173 force clamp to follow the assembly of human initiation complexes in the RNAP II and RNAP III systems

174 unteracts the formation of transcription pre-initiation complexes in vitro and represses abortive and

175 play key roles: in the assembly of the C5b-8 initiation complex; in driving and regulating the openin

176 facilitate the assembly of the transcription initiation complex including SL1 and Pol I.

177 embles a RNA polymerase II transcription pre-initiation complex including TFIIH.

178 c DNA replication is the assembly of the pre-initiation complex, including the formation of two head-

179 The coagulation initiation complex induced rapid and prolonged enhanceme

180 (fMet) that occur during maturation of a 70S initiation complex into a 70S elongation-competent compl

181 ation and aggregation of stalled translation initiation complexes into stress granules are severed, l

182 s (UAS), assembly of Mediator within the pre-initiation complex is accompanied by the release of CKM.

183 The ribosomal initiation complex is assembled on the mRNA via a cap-de

184 The periphery of the core initiation complex is decorated by additional polymerase

185 E-BP1 bound to the cap-dependent translation initiation complex is decreased when the expression of P

186 nscription factor Mtf1, we show that the pre-initiation complex is highly dynamic and undergoes repet

187 pharmacological blockade of the translation initiation complex is highly effective against these tum

188 Our data indicate that the pre-initiation complex is likely to be an important target f

189 d to which membrane structures the autophagy-initiation complex is localized have not been fully char

190 the formation of the PL-rich apoB-containing initiation complex is mediated to a large extent by PLTP

191 Rapid and accurate formation of the 70S initiation complex is promoted by initiation factors, wh

192 y of the components of the transcription pre-initiation complex is proposed to control cell type-spec

193 anslation initiation, the 43 S ribosomal pre-initiation complex is recruited to the 5'-end of an mRNA

194 P2), a critical component of the translation initiation complex, is a calpain substrate.

195 form of the enzyme might constitute the pre-initiation complex leading to its unwinding activity.

196 increase the probability that MutS-MutL MMR initiation complexes localize near the mismatch.

197 nthetic enzymes and found that the autophagy-initiation complex localizes to phosphatidylinositol syn

198 llion dalton, Mediator-RNA polymerase II pre-initiation complex (Med-PIC) was assembled and analyzed

199 formational transitions of the transcription initiation complex must be central for such control, but

200 s of the pre- and postcatalytic forms of the initiation complex of bacteriophage N4 RNA polymerase th

201 ctive TF, assembly of the ternary TF-VIIa-Xa initiation complex of blood coagulation, and the EPCR-de

202 of POLR3E involves the assembly of defective initiation complexes of Pol III.

203 n antibody that primarily recognizes the pre-initiation complexes of RNA polymerase II, we explore th

204 The initiation complexes of the lectin pathway consist of a

205 s detectable or functionally required at the initiation complexes of these promoters.

206 Analysis of the Pol II pre-initiation complex on immobilized chromatin templates re

207 aPLs dissociate an inhibited TF coagulation initiation complex on the cell surface of monocytes, the

208 ion of the human mitochondrial transcription initiation complex on the light-strand promoter (LSP) th

209 e assembly of the eIF4F-mediated translation initiation complex on the mRNA cap through directly bind

210 nd disrupted assembly of the transcriptional initiation complex on the SREBP-1c promoter.

211 nsights into the organization of translation initiation complexes on active mRNAs and unanticipated c

212 scanning 43S complexes and formation of 48S initiation complexes on AUG codons immediately upstream

213 Our data suggest that assembly of the pre-initiation complexes on LSP and HSP brings these transcr

214 kinases (MAPKs), which it recruits into pre-initiation complexes on target gene promoters.

215 eIF4G3 which, unlike the standard eukaryotic initiation complex paradigm, binds tightly to eIF4E4, bu

216 led the position of TFE/TFIIE within the pre-initiation complex (PIC) and illuminated its role in OC

217 Loading of mRNA onto the ribosomal 43S pre-initiation complex (PIC) and its subsequent scanning req

218 I)-dependent transcription by nucleating pre-initiation complex (PIC) assembly at the core promoter.

219 ocess involving multiple steps, from 43S pre-initiation complex (PIC) assembly, to ribosomal subunit

220 nent of SAGA to promote the formation of pre-initiation complex (PIC) at the core promoter and, conse

221 The eukaryotic pre-initiation complex (PIC) bearing the eIF2.GTP.Met-tRNAi(

222 In Saccharomyces cerevisiae, a pre-initiation complex (PIC) comprised of Pol II and conserv

223 ukaryotes begins with the formation of a pre-initiation complex (PIC) containing the 40S ribosomal su

224 TAF4 promotes pre-initiation complex (PIC) formation at post-natal express

225 and is the first step in the process of pre-initiation complex (PIC) formation on promoter DNA.

226 The translation pre-initiation complex (PIC) scans the mRNA for an AUG codon

227 iption initiation, a large multi-subunit pre-initiation complex (PIC) that assembles at the core prom

228 s a central player in recruitment of the pre-initiation complex (PIC) to mRNA.

229 RNA polymerase II (pol II) transcription pre-initiation complex (PIC) were determined by means of cry

230 II (Pol II) begins with assembly of the pre-initiation complex (PIC), comprising Pol II and the gene

231 sted the contributions of the RNA Pol II pre-initiation complex (PIC), mediator and cohesin to establ

232 RNAPII) transcription is governed by the pre-initiation complex (PIC), which contains TFIIA, TFIIB, T

233 ess a promoter architecture, including a pre-initiation complex (PIC), which mirrors that at the 5' r

234 ecruitment to the eukaryotic translation pre-initiation complex (PIC).

235 he upstream promoter and assemble into a Pre-Initiation Complex (PIC).

236 on of genes originate from transcription pre-initiation complexes (PICs).

237 The host eIF4F translation initiation complex plays a critical role the translation

238 In the partially melted initiation complex (PmIC), transcription factor MTF1 mak

239 Incorporation of repressive ncRNAs into pre-initiation complexes prevents transcription initiation,

240 the paths of the DNA strands in the complete initiation complexes provide insights into the mechanism

241 determination of the crystal structure of an initiation complex provided insight into the initiation

242 tive model that eIF5 and eIF5B cause 43S pre-initiation complex rearrangement favoring more efficient

243 Remarkably, stalled initiation complexes remain in dynamic scrunching and un

244 r architecture of RNAP II-like transcription initiation complexes remains opaque due to its conformat

245 the fork and forms a stably bound helicase "initiation complex." Replacement of GTPgammaS with GTP p

246 ding formation of a stable transcription pre-initiation complex required for its activation.

247 e first structure of a reverse transcription initiation complex (RTIC) that trapped the complex after

248 Structural studies of reverse transcriptase initiation complexes (RTICs) have revealed unique confor

249 tion initiation factor 4 gamma 1 translation initiation complex scaffolding protein that is mediated

250 with promoter DNA and inhibits formation of initiation complexes, sensitizing rRNA synthesis to chan

251 As aggregates of stalled initiation complexes, SGs are defined by the presence of

252 transcription machineries revealed that all initiation complexes share a conserved core.

253 wo factors can act on the same transcription initiation complex simultaneously.

254 DNA sequence and shape analysis of initiation complex sites suggest that both sequence and

255 The conserved core initiation complex stabilizes the open DNA promoter comp

256 study, we determined a series of transcript initiation complex structures from the pyrG promoter usi

257 ts demonstrate a compact organization of the initiation complex, suggesting that protein-protein inte

258 ding bacteriophage T4-coded helicase hexamer initiation complex, suggesting that these motions may pl

259 of general transcription factors into a pre-initiation complex that ensures the accurate loading of

260 iption occurs upon sequential assembly of an initiation complex that includes mitochondrial RNA polym

261 tochondrial transcription intermediate-a pre-initiation complex that includes mtRNAP, TFAM and promot

262 joining of the 60S subunit to produce an 80S initiation complex that is competent for elongation.

263 quent recruitment of mtRNAP results in a pre-initiation complex that is remarkably similar in topolog

264 esent the structure of de novo transcription initiation complex that reveals unique contacts of the i

265 es display a highly stressed pretranslocated initiation complex that traps a pyrophosphate at the act

266 These findings suggest that the autophagy-initiation complex, the PIS-enriched ER subdomain, and A

267 mational changes during formation of the 70S initiation complex, the structures of any intermediates

268 n does not have a "blind spot." In assembled initiation complexes, the cap was no longer associated w

269 e in arginine methylation of the translation initiation complex, thereby disrupting its assembly and

270 nscripts are released from the transcription initiation complex, thereby reducing the level of gene e

271 l structure of a mycobacterial transcription initiation complex (TIC) with RbpA as well as a CarD/Rbp

272 e crystal structures of E coli transcription initiation complexes (TICs) containing the stress-respon

273 yo-EM) to determine a structure of the eIF5B initiation complex to 6.6 angstrom resolution from <3% o

274 CR interacts with the ternary TF coagulation initiation complex to enable PAR signaling and suggest t

275 A (fMet-tRNA(fMet))-containing 30S ribosomal initiation complex to form a 70S initiation complex, whi

276 hances translation by recruiting the 48S pre-initiation complex to newly exported mRNAs, through an i

277 -dependent trafficking of the ULK1 autophagy initiation complex to the phagophore.

278 mutually exclusive binding of transcription initiation complexes to closely opposed forward and reve

279 that Brucella selectively co-opts autophagy-initiation complexes to subvert host clearance and promo

280 nteraction, for directing the binding of pre-initiation complexes to the 5'-ends of mRNAs and for bia

281 plex, similar to sigma2 in the transcription initiation complex, to stabilize the junction, and there

282 rase III subunits for the closed to open pre-initiation complex transition.Transcription initiation b

283 Then, the initiation complex translocates to the ATG9A-positive au

284 re of the HIV genomic RNA-human tRNA(Lys)(3) initiation complex using heteronuclear nuclear magnetic

285 athways regulate the assembly of translation initiation complexes, using the cap analog m7GTP to enri

286 5'-UTR of a viral RNA assembles a functional initiation complex via an uAUG intermediate.

287 icroscopic structure of cMed bound to a core initiation complex was determined at 9.7 A resolution.

288 n the human mitochondrial core transcription initiation complex, was 74% lower in septic patients (p

289 phosphorylated rpS6 bound to the translation initiation complex were increased in PHLPP-knockdown cel

290 multiple genes involved in formation of the initiation complex were translationally altered during b

291 mon resonance, DNA polymerase III holoenzyme initiation complexes were formed on an immobilized gappe

292 hat the transition of the closed to the open initiation complex, which occurs concomitant with DNA me

293 A to the small ribosomal subunit to form the initiation complex, which subsequently associates with t

294 S ribosomal initiation complex to form a 70S initiation complex, which subsequently matures into a 70

295 on crystal structure of an Msm transcription initiation complex with a promoter DNA fragment.

296 R elicits association of the Vps34 autophagy initiation complex with JB12.

297 -dimensional reconstructions of yeast MtRNAP initiation complexes with and without the mitochondrial

298 hen scan to the initiation codon to form 48S initiation complexes with established codon-anticodon ba

299 hondrial DNA (mtDNA) transcription and forms initiation complexes with human mitochondrial transcript

300 nables reconstituted eIF3 to assemble intact initiation complexes with the HCV IRES.