ライフサイエンスコーパス: initiation site

1 manner that exposes a potential replication initiation site.

2 ed just proximal to the alternative in-frame initiation site.

3 mal subunit and in selecting the translation initiation site.

4 upstream of the presumptive transcriptional initiation site.

5 polypyrimidine tract located 11 nt from the initiation site.

6 re 1.7 kb fragment 5' of the transcriptional initiation site.

7 between bp -158 and +30 of the transcription initiation site.

8 inate as local neuronal ensembles within the initiation site.

9 itiating upstream of the known transcription initiation site.

10 contributing factors in the selection of the initiation site.

11 inning 17 bp downstream of the transcription initiation site.

12 and definitively identify the authentic ORF3 initiation site.

13 mately 5 kb upstream of the flk1 translation initiation site.

14 tion -43.5 with respect to the transcription initiation site.

15 I4-kinase, PI4KIIIbeta, to the autophagosome initiation site.

16 tivator to the GAL10 antisense transcription initiation site.

17 g11 concentrates Atg32 to generate mitophagy initiation sites.

18 mRNAs produced via alternative transcription initiation sites.

19 base pairs in width, fixed at RNA polymerase initiation sites.

20 possibly, the usage of multiple translation initiation sites.

21 and adopt perpendicular orientation at valve initiation sites.

22 l peptide and putative alternate translation initiation sites.

23 t Z-lines, consistent with RyR2 and Ca spark initiation sites.

24 cells identified multiple MRP2 transcription initiation sites.

25 rate prediction of single-peak transcription initiation sites.

26 matic predictions of alternative translation initiation sites.

27 icated in targeting the complex to autophagy initiation sites.

28 ased utilization of downstream transcription initiation sites.

29 omoter and mapped its multiple transcription initiation sites.

30 w mechanism for targeting ORC to replication initiation sites.

31 inus that can act as alternative translation initiation sites.

32 ive elements act as autonomous transcription initiation sites.

33 nt DNA double-strand breaks act as silencing initiation sites.

34 on by increasing discrimination against poor initiation sites.

35 ) protein that binds a subset of replication-initiation sites.

36 ning required to maintain open transcription-initiation sites.

37 ent requires both the CGG repeat and CGG RAN initiation sites.

38 e important for replicating regions far from initiation sites.

39 in a corresponding shift in DNA replication initiation sites.

40 marks characteristic of active transcription initiation sites.

41 nal modification and alternative translation initiation sites.

42 A was isolated and found to contain a single initiation site 71 nt from the most 5' end, an open read

43 igh-resolution maps of meiotic recombination initiation sites across the genomes of budding yeast and

44 rved an enrichment of footprints at inferred initiation sites after drug-induced arrest of translatio

45 GABAergic synapses and the action potential initiation site along the AISs is not well defined.

46 endosomes to the midbody and apical membrane initiation site (AMIS) during lumenogenesis.

47 ituitary hormone secretion possesses a spike initiation site and conducts action potentials while als

48 reporter gene replacing the Enam translation initiation site and gene sequences through exon 7.

49 study we identified a new RSK4 transcription initiation site and several alternative splice sites wit

50 f the HAS2 gene identified the transcription initiation site and showed that region F3, comprising th

51 ethionine codons while leaving open the true initiation site and that the final recognition of the in

52 and by changing the distance between mlonRNA-initiation site and the transcription factor-binding sit

53 2,584 bp upstream of the TERT transcription initiation site and were all in the opposite transcripti

54 hibited abnormal voltage-Ca(2+) delay at the initiation site and were inhibited by either sarcoplasmi

55 ment allowed us to confirm known translation initiation sites and also reveal putative novel initiati

56 CELSR1 regulating the direction of dendrite initiation sites and CELSR2/3 controlling radial migrati

57 ain structure abrogates the need for precise initiation sites and creates a scaffold for the evolutio

58 CGIs often include transcription initiation sites and display 'active' histone marks, not

59 gamma (iPLA2gamma) with multiple translation initiation sites and dual mitochondrial and peroxisomal

60 for shaping Atg32 into functional mitophagy initiation sites and for delivery of mitochondria to the

61 ene transcription from cryptic transcription initiation sites and in mitigating RNA polymerase II pro

62 nstability; therefore, we mapped replication initiation sites and prereplication complex protein bind

63 The initiation sites and restricted propagation of waves at

64 de important information about transcription initiation sites and the approximate locations of local

65 roteasome has pronounced preferences for the initiation site, and its recognition represents a second

66 itiated upstream of the normal transcription initiation site, and was strongly regulated by both cisp

67 the number of assembly pathways and assembly initiation sites, and resulting in enhanced assembly eff

68 Multiple active translation initiation sites appear to operate in several plant gene

69 We mapped the transcription initiation site approximately 116 bp 5' to the translati

70 nhancer-like distal sequence element and the initiation site are protected during interphase whereas

71 We conclude that fracture initiation sites are controlled primarily by contact dam

72 RNA polymerase transcription initiation sites are largely unknown in Caenorhabditis e

73 es of the major splice donor and translation initiation sites are sequestered by long-range base pair

74 Alternative initiation sites are utilized for the synthesis of impor

75 NFRs associated with transcription initiation sites as well as those not associated with pr

76 e protection assays mapped the transcription initiation site at 32 nucleotides upstream of the UXP ge

77 A polymerase II is targeted to the antisense initiation site at GAL10 by Reb1p activator as well as g

78 iates with the GAL10 antisense transcription initiation site at the 3' end of the coding sequence.

79 tion of RNA polymerase II with the antisense initiation site at the 3' end of the GAL10 coding sequen

80 ll or pause within tens of base pairs of its initiation site at the promoter, a state that may reflec

81 The initiation sites at oriC1 were determined by replication

82 Translation inhibitors were used to map initiation sites at single-nucleotide resolution at the

83 ET) not only allowed mapping of conventional initiation sites at the beginning of the genes, but stri

84 ers revealed the presence of two replication initiation sites at the template strand and evidence for

85 rmatic prediction of alternative translation initiation sites (aTIS).

86 l II) pauses downstream of the transcription initiation site before beginning productive elongation.

87 Pak1 to the plasma membrane at the dendrite initiation site before the activation of Cdc42.

88 binding site proximal to the transcriptional initiation site; both SRC-1 and c-Jun were recruited to

89 riction fragments that contained replication initiation sites (bubbles) in vivo.

90 els determine AP repolarization at the spike initiation site but not at more distal sites, limiting t

91 nsic cues guide sprouts after they leave the initiation site, but these cues are likely insufficient

92 and Mcm4 bound near each of the replication initiation sites, but a dramatic change in (CTG)(n) .

93 icate that Mcm10 is localized to replication initiation sites by directly binding MCM through the Mcm

94 r sequence-specific recognition of packaging initiation sites by lateral interdigitation of DNA.

95 e p19 promoter and defined its transcription initiation sites by the 5'-rapid amplification of cDNA e

96 lassification used, synthesized from varying initiation sites by the living anionic ring opening poly

97 at the subcellular scale (number of Ca wave initiation sites), cellular scale (sarcoplasmic reticulu

98 both Ser5 and Ser2 phosphorylation, affects initiation site choice, and inhibits elongation efficien

99 show that DNA sequences surrounding the IMD2 initiation site constitute a repressive element (RE) inv

100 entical junction upstream of the translation initiation site created CYP19 mRNA encoding functional a

101 he enzyme's ability to locate the downstream initiation site decreased exponentially as the start was

102 The centromeric and first euchromatic SC initiation sites depend on the cohesion protein ORD.

103 TREK-2 that has three potential translation initiation sites (designated M(1)M(2)M(3)) within the N-

104 The HIV-1 Dimerization Initiation Site (DIS) is an intriguing, yet underutilize

105 s a monomer, as the palindromic dimerization initiation site (DIS) is sequestered via base pairing to

106 sing interaction formed via the dimerization initiation site (DIS) loop sequence, which has been prop

107 a a self-complementary sequence in the dimer initiation site (DIS) of the genomic RNA, but that dimer

108 Dimerization is initiated at the dimer initiation site (DIS) which encompasses stem-loop 1 (SL1

109 g frame (ORF) that may act as a dimerization initiation site (DIS), enabling the virus to package two

110 lel orientation by interactions at the dimer initiation site (DIS).

111 of stem-loop 1 (SL-1), also termed the dimer initiation site (DIS).

112 itiation of translation at a downstream M231 initiation site distinct from that of full-length mRNA.

113 lementary alpha and beta motifs in the dimer initiation site driven by long-range electrostatic inter

114 We investigate whether, at a given initiation site, DSBs occur independently among the four

115 frequencies only if AP onset was fast at the initiation site (e.g., attributable to cooperative gatin

116 The use of alternative translation initiation sites enables production of more than one pro

117 ation was enabled by alternative translation initiation sites encoding distinct targeting signals.

118 s redirected towards unconventional upstream initiation sites, enhancing the translational efficiency

119 ream of the distal gene 50/RTA transcription initiation site exhibited promoter activity in both perm

120 The endoplasmic reticulum (ER) serves as an initiation site for autophagosomes and is also remodeled

121 both composition and structure to become the initiation site for de novo formation of a membrane call

122 chors DnaA to Lon and the other acting as an initiation site for degradation.

123 ating its transcytosis to an apical membrane initiation site for lumen formation.

124 ns more than 1,000 bp from the transcription initiation site for most of these genes.

125 virus infection and is likely the authentic initiation site for ORF3.

126 The transcription initiation site for pri-miR-216a was delineated, and one

127 after the canonical 3'-GPyPy (Py is T or C) initiation site for primer synthesis showed that only UL

128 nstream of its gene that is also a preferred initiation site for priming by CCPol-MP.

129 nd identification of alternative translation initiation sites for a group of mRNA sequences that have

130 e N-terminal KTK(E/Q)GV repeats may serve as initiation sites for aggregation in mouse aS.

131 ys were used to identify two transcriptional initiation sites for algR within the algZ coding region,

132 ocessive cellulases exploit these defects as initiation sites for hydrolysis.

133 Utilization of alternative initiation sites for protein translation directed by non

134 res that allow identification of alternative initiation sites for protein translation.

135 demonstrated to utilize alternative non-AUG initiation sites for protein translation.

136 PrP(C)s to mechanical force to decipher the initiation sites for the transition from PrP(C) to an ag

137 er sequence that distinguishes the preferred initiation site from a plethora of IRES-encoded AUG trip

138 ity of these cells to Ag and shifts the wave initiation site from protrusions to the cell body.

139 Mutation of the second and third initiation sites from Met to Leu (M(1)L(2)L(3)) produced

140 Spatial accuracy for determining initiation sites from pacing was 6 mm.

141 or prolonged network activity may alter the initiation site geometry thus affecting cell excitabilit

142 The dimer initiation site has been characterized to some extent, b

143 is removed by trans-splicing, and noncoding initiation sites have not been investigated.

144 That is, initiation sites have the locally "best" initiator (INR)

145 the method consists of enhanced translation initiation site identification, ability to identify sequ

146 Ribosome binding to the translation initiation site impedes degradation by both mechanisms.

147 logy to mutate a single internal translation initiation site in Cx43 (M213L mutation), which generate

148 as the only step necessary for selecting the initiation site in prokaryotes.

149 OC1, which is part of the daughter centriole initiation site in Tetrahymena.

150 w that the absence of a strong transcription initiation site in the G11 gene results in the productio

151 d from full-length viral mRNA at an upstream initiation site in the same reading frame as Pr65(gag),

152 482 to 684 bp upstream of the transcription initiation site in vitro.

153 scQC, the product of an internal translation initiation site in yscQ, for their cooperative assembly.

154 t is largely restricted from transcriptional initiation sites in active regions.

155 sites, polyadenylation sites and translation initiation sites in both the native and fusion contexts.

156 s were common in ARVC patients with variable initiation sites in both ventricles.

157 red with 8-oxoguanine (G(O)) also act as MMR initiation sites in extracts of human cells or Xenopus l

158 tiation sites and also reveal putative novel initiation sites in intergenic regions and within genes.

159 and, particularly, in predicting translation initiation sites in modelled as well as in assembled tra

160 find that the vast majority of recombination initiation sites in mouse males are associated with test

161 ts that there are many potential replication initiation sites in permissive parts of the genome, most

162 he genome-wide distribution of recombination initiation sites in Prdm9 knockout mice and in two mouse

163 Rab27B and beta4 integrin to early adhesion initiation sites in spreading normal keratinocytes.

164 Mapping of replication initiation sites in the HAC revealed that replication pr

165 he genome-wide distribution of recombination initiation sites in the mouse genome.

166 ng and short, due to alternative translation initiation sites in the N-terminal cytoplasmic tail.

167 evidence that there are many more potential initiation sites in the S. pombe genome than previously

168 ominated by the number of pre-existing crack-initiation sites in the sample.

169 Characterization of Ps1 transcription initiation sites in this allelic series revealed several

170 the drug harringtonine arrested ribosomes at initiation sites in this archaeon.

171 tate cancers, and share the same translation initiation site (in ERG exon 4) with the commonly observ

172 The initiation site, in other words, is a varied sequence of

173 sequences near and upstream of transcription initiation sites, in intronic regions, and within interg

174 ine pulses) increased, the number of Ca wave initiation sites increased, integrated Ca transients and

175 e KO lines (increased number of lateral root initiation sites) indicate that AtNBR1 is essential for

176 of a polycytosine track upstream of the HSP2 initiation site, influence transcriptional activity.

177 riginate within a spatially confined seizure initiation site (intrafocal region), and subsequently pr

178 and nucleotide that immediately precedes the initiation site is a purine.

179 located 96-bp upstream of the transcription initiation site is critical for the activation of the pr

180 nthesis from a relatively weak translational initiation site is greatly influenced by the presence or

181 n the ICP4-binding site at its transcription initiation site is mutated, suggesting that ICP4 may pla

182 nd nuclease mapping revealed that the gene X initiation site is sequestered in an extended RNA second

183 b sequence upstream of the Nrl transcription initiation site is sufficient to drive reporter gene exp

184 TIE located at 401 bp from the transcription initiation site, is required for TGFbeta repression of t

185 around canonical and alternative translation initiation sites, is dynamic in response to physiologica

186 nduced dissociation of the MMLV dimerization initiation site kissing loop.

187 Two dimerization initiation site kissing sequences, Mal and Lai, have bee

188 Immediately distal to this initiation site, lamellae of increasing diameter are evi

189 of Rv1813c and direct transcription from an initiation site located several hundred base pairs upstr

190 n analysis identified two rpoS transcription initiation sites located 43 bp (P1) and 63 bp (P2) upstr

191 transcripts initiating from 2 transcription initiation sites located upstream of the currently defin

192 nthesis from the much weaker maturation gene initiation site, located 1300 nucleotides upstream.

193 icates that the ribosomal recognition of the initiation site may be the result of multiple interactio

194 ng on circuit 'choke points' remote from the initiation site might be as important as that of the ini

195 onsistently assemble provided a small "dimer initiation" site near the actin binding domain is presen

196 reveal that pausing is not fixed relative to initiation sites, nor is it specified directly by the po

197 n site and that the final recognition of the initiation site occurs by cooperativity and cumulative s

198 mbly of Hfq and Crc bound to the translation initiation site of a target mRNA.

199 ger complex, from the central spindle to the initiation site of cytokinesis.

200 ible state within 290 bp downstream from the initiation site of metabolic-stress-induced lncRNAs (mlo

201 This locus overlaps the transcription initiation site of RASGRF1, which is highly expressed in

202 ricted to within 150 bp of the transcription initiation site of the active Drosophila melanogaster Hs

203 nd the first heminode, which forms the spike initiation site of the auditory nerve.

204 n that utilizes TRPC channels to specify the initiation site of the Ca(2+) response.

205 n the 200 bp upstream from the transcription initiation site of the FcRgamma promoter.

206 n the region upstream from the transcription initiation site of the gene encoding B lymphoid tyrosine

207 In this study, we show that the +3 initiation site of the Le is utilized with apparently hi

208 a flanking the 3-kb fragment upstream of the initiation site of the mouse NPC1L1 gene in mouse colon

209 We mapped the transcription initiation sites of all three primary miRNA transcripts

210 ICP4-binding sequences at the transcription initiation sites of both HSV-2 LAT (pri-miRNA for miR-I

211 Analysis of the initiation sites of Ca2+ sparks within the same junction

212 has an important function in determining the initiation sites of DNA replication.

213 t GABPalpha is associated with transcription initiation sites of genes encoding key molecules in TCR

214 one or two nucleotides of the transcription initiation sites of genes transcribed by RNA polymerase

215 re over-represented near the transcriptional initiation sites of immune response genes.

216 activation domain binds to the transcription initiation sites of these promoters and stimulates TFIIH

217 +66, and +186 relative to the transcription initiation site on the HIV long terminal repeat (LTR).

218 r region at the 3' end of the genome has two initiation sites, one at position +1, opposite the 3' te

219 erential targeting is effected by use of two initiation sites, one of which includes a mitochondrial

220 protein by utilizing alternative translation initiation sites: one (short form) with the nuclear loca

221 chromosomes requires thousands of potential initiation sites, only a small fraction of which are sel

222 c marks associated with active transcription initiation sites overlap with regions of reduced relativ

223 poE mRNA identified five new transcriptional initiation sites (P1 to P5) located distal to Esigma(E)-

224 nd SR Ca load, whereas the number of Ca wave initiation sites per myocyte is less important.

225 A kissing complex formed by the dimerization initiation site plays a critical role in the survival an

226 of a developmental regulation in translation initiation site preference for a T. gondii protein.

227 somes and subsequently targeted to preferred initiation sites prior to the next S phase.

228 n from the second (M(2)L(3)) or third (M(3)) initiation site produced the approximately 54 kDa isofor

229 and -c in order) occurs with transcriptional initiation sites progressing 5' to 3' upstream of the fb

230 uA4 KAT to the GAL10 antisense transcription initiation site promotes GAL10 antisense transcription.

231 ogenesis has focused on the ovary as a tumor initiation site, recent studies suggest that there may b

232 ells and provides a quantitative estimate of initiation site redundancy.

233 ein interactions at subgroups of replication initiation sites (replication origins) modulate the ubiq

234 mRNA to an alternative, in-frame translation initiation site, resulting in the prevention of nonsense

235 roximal and distal gene 50/RTA transcription initiation sites revealed that the distal promoter is pa

236 combines weighted, signal-based translation initiation site scores and the contrast in coding potent

237 nct sites; however, the principles governing initiation site selection are unclear because proteins e

238 r, it displays a dichotomous requirement for initiation site selection between reading frames, with i

239 te data can be unified into a model in which initiation site selection is driven almost entirely by e

240 Ac transposase does not influence transcript initiation site selection.

241 elimbic cortex, which innervate PCs at spike initiation site, selectively control PCs projecting to t

242 In fact, comparison of a large number of initiation site sequences revealed that the sites are co

243 lution origin mapping technique that we call initiation site sequencing (ini-seq).

244 High-resolution mapping of replication initiation sites showed that replication initiation even

245 dingly, we conducted an analysis of synaptic initiation sites (SISs) and COs in human and mouse sperm

246 id hormone response element to transcription initiation site slide bi-directionally, with the third n

247 cZ inserted in frame at the Klk4 translation initiation site so that the endogenous Klk4 promoter dri

248 fied a handful of previously unknown non-AUG initiation sites, some of which serve as the exclusive s

249 mber of transcripts with novel transcription initiation sites, spliced variants and alternative polya

250 clustered but distinct M2 gene transcription initiation sites suggesting the presence of multiple pro

251 NCR) and one at the prominent lagging-strand initiation site termed Ori-L.

252 DNA replication starts at initiation sites termed replication origins.

253 x/pro-SCP-2 gene is a fusion gene having two initiation sites that generate a long (SCP-x; 58.9-kDa)

254 e also identified novel putative translation initiation sites that were mostly associated with short

255 e pairing of a unique leader sequence in the initiation site--the SD sequence--with the 3' end of the

256 eplication forks were stalled close to their initiation sites; therefore, copy number enrichment was

257 Data presented here identify replication initiation sites throughout the genome, providing a foun

258 Translation initiation site (TIS) identification is an important asp

259 Timely identification of the translation initiation site (TIS) is very important for conducting i

260 Proper selection of the translation initiation site (TIS) on mRNAs is crucial for the produc

261 nderstand how ribosomes choose a translation initiation site (TIS).

262 d comprehensive determination of translation initiation sites (TIS) across the entire transcriptome.

263 thm is able to predict genes and translation initiation sites (TIS) more accurately than Orphelia whi

264 ht transcripts by using four transcriptional initiation sites (TIS; resulting in three different init

265 urate detection of human mtDNA transcription initiation sites (TISs) in the heavy and light strands r

266 r, the evidence for noncanonical translation initiation sites (TISs) is largely indirect and based on

267 In addition to the annotated translation initiation sites (TISs), the translation process may als

268 ty of spike patterns propagated from a spike initiation site to a synaptic target, and that neuromodu

269 silencing did not spread from the silencing initiation site to adjacent cells.

270 )-induced gene silencing can spread from the initiation site to nearby cells.

271 ealed that the fast activation localized the initiation site to the proximal axon even upon strong sy

272 We assign transcription initiation sites to 7691 protein-coding genes and find t

273 ependent on sequence context at the multiple initiation sites to condition specific binding of at lea

274 mbined product yield as measures of relative initiation site usage and productive ribosome recruitmen

275 , we observe a striking shift in translation initiation site usage.

276 dium resolution structure of the heterodimer initiation site using homology modeling coupled with str

277 sful bioinformatic prediction of alternative initiation sites utilized in protein translation.

278 The presence of upstream translation initiation sites (uTISs) at the mRNA 5' untranslated reg

279 e-specifically upstream of the transcription initiation site via a DNA-binding domain (DBD).

280 Additionally, the calcium signal initiation site was altered upon C-CGB expression in neu

281 ound 240 bases upstream from the translation initiation site was of functional significance and inclu

282 the ZV motif located near the transcription initiation site, was abundant in HeLa cells, while it wa

283 ractionation) of the atrial signal at the AF initiation site were rate-dependent (both p = NS).

284 en -70 and +27 relative to the transcription initiation site were sufficient to confer a high level o

285 ranscription start sites and the translation initiation sites were governed by the gamma distribution

286 Transcription initiation sites were highly supported by conserved arra

287 The transcription initiation sites were mapped by primer extension.

288 associated with these additional translation initiation sites were short, raising questions regarding

289 Transcription initiation sites were similar in Ac and Ds derivatives,

290 replication forks and the average density of initiation sites, were conserved among the cells analyze

291 Activated Akt was enhanced at branch initiation sites where its negative regulator, PTEN, was

292 asts revealed a novel upstream transcription initiation site, which was also utilized during wild-typ

293 Usage of this non-canonical initiation site with its weak translation initiation eff

294 Additional putative translational initiation sites with AUG or alternative codons occurred

295 his technique has revealed novel translation initiation sites with unprecedented scope and has furthe

296 4 gene sequence, starting at the translation initiation site, with a lacZ reporter gene.

297 otein syntheses were initiated at these uAUG initiation sites, with the third uAUG initiating the hig

298 urprisingly, TL-seq identified transcription initiation sites within 6% of protein-coding regions, an

299 ereby creating a database of all replication initiation sites within nonrepetitive DNA in two human c

300 rom +3 and that the RdRp could access the +3 initiation site without prior initiation at +1.