ライフサイエンスコーパス: initiator protein

1 alone has all the activities expected of an initiator protein.

2 f organisms is multiple binding sites for an initiator protein.

3 , for binding a plasmid-specific replication initiator protein.

4 hich interacts specifically with a different initiator protein.

5 tor for inversion stimulation (Fis) and DnaA initiator protein.

6 ctivity consistent with the properties of an initiator protein.

7 the origin recognition complex, the putative initiator protein.

8 ion factors, including the Cdc18 replication initiator protein.

9 retained binding to the viral E1 replication initiator protein.

10 9 bp sequence that binds the P1-encoded RepA initiator protein.

11 adjacent to the binding site for the dimeric initiator protein.

12 wo residues in the helicase domain of the E1 initiator protein.

13 of the DNA molecule, allowing binding of the initiator protein.

14 ary chromosome replication requires the RctB initiator protein.

15 g, while the repC gene encodes a replication initiator protein.

16 low selectivity observed for DNA binding by initiator proteins.

17 a characteristic of other viral and cellular initiator proteins.

18 helix topology with a unique structure among initiator proteins.

19 s common to rolling-circle replication (RCR) initiator proteins.

20 on in the theta mode and requires binding of initiator proteins.

21 opic activity of the geminivirus replication initiator proteins.

22 designated by their recognition by specific initiator proteins.

23 nt in the helicase domain of all papovavirus initiator proteins.

24 eplication by limiting supply or activity of initiator proteins.

25 by limiting the synthesis or availability of initiator proteins.

26 A unifying characteristic of DNA replication initiator proteins across the kingdoms of life is their

27 cognition complex (ORC) is a DNA replication initiator protein also known to be involved in diverse c

28 the origin recognition complex (ORC) is the initiator protein and replication protein A (RPA; ref.

29 pillomavirus type-1 is the viral replication initiator protein and replicative helicase.

30 was previously shown to require both the E1 initiator protein and the E2 transactivator protein.

31 Discerning the interactions between initiator protein and the origin of replication should p

32 the gamma origin for the plasmid-encoded pi initiator protein and three host-encoded proteins, DnaA,

33 action of structurally conserved ATP-binding initiator proteins and origin DNA to mediate assembly of

34 recise and reproducible interactions between initiator proteins and replication origins to assemble a

35 modest DNA-binding specificity exhibited by initiator proteins and the high specificity of initiatio

36 e-strand origin, the domain structure of the initiator proteins and the molecular basis for the funct

37 of the biochemical activities of the plasmid initiator proteins and their interaction with the double

38 origin recognition complex, the replication initiator protein, and one or more accessory sequences.

39 Multiple binding sites for an initiator protein are a common feature of replicator seq

40 Initiator proteins are critical components of the DNA re

41 The conjugative initiator proteins are key players in the DNA processing

42 This finding implies that oversupplied initiator proteins are largely dimeric, partly accountin

43 Viral replication initiator proteins are multifunctional proteins that uti

44 Viral initiator proteins are polypeptides that form oligomeric

45 hat are required to recruit DNA polymerase - initiator proteins - are often used to regulate the timi

46 multiple binding sites for their respective initiator proteins arranged as inverted repeats.

47 quid-like networks, we tuned the strength of initiator protein assembly in real time using light-indu

48 The action of the initiator protein at the origin of transfer (oriT) is go

49 ation requires a specific orientation of the initiator protein at the origin.

50 ding and hydrolysis in the papillomavirus E1 initiator protein based on the recent structural data.

51 t of replicative helicases via the action of initiator proteins belonging to the AAA+ superfamily of

52 been mapped to the N-terminal region of the initiator protein between residues 1 and 116.

53 DNA replication initiator proteins bind site specifically to origin site

54 and plasmids indicate that their replication initiator proteins bind to origins of replication at man

55 These initiator proteins bind to the origin of replication thr

56 at a considerable distance from the primary initiator protein binding sites (iterons).

57 ma of R6K, contains tandem iterons (iterated initiator protein binding sites), an AT-rich region that

58 Analyses of multiple initiator proteins bound to their cognate origins have p

59 DnaB showed ATPase activity, also typical of initiator proteins, but only drDnaB exhibited 5' 3' dsDN

60 antisense RNA that regulates the replication initiator protein by a translational attenuation mechani

61 A flexible condensate of initiator proteins catalyzes assembly of clathrin-coated

62 However, loading of the initiator protein Cdc45 onto chromatin cannot take place

63 The initiator protein Cdc6 (Cdc18 in fission yeast) plays an

64 e correlated with the reassembly of the CD28-initiator protein complex.

65 Previous studies have demonstrated that the initiator proteins contain separate DNA binding and nick

66 n the surface of domain I of the replication initiator protein, corresponding to the binding site use

67 ne via a transesterification that leaves the initiator protein covalently bound on the 5'-end of the

68 hese results further link the actions of the initiator protein, Dbf4p, to the completion of mitosis a

69 eria must carefully regulate the activity of initiator protein DnaA and its interactions with the uni

70 gh regulation of the interaction between the initiator protein DnaA and specific DNA elements arrayed

71 F ori (oriV) and required both the bacterial initiator protein DnaA and the plasmid-encoded initiator

72 ts its control through interactions with the initiator protein DnaA and the sliding clamp DnaN.

73 Escherichia coli replication initiator protein DnaA binds ATP with high affinity but

74 similar nucleoprotein complex comprising the initiator protein DnaA bound to three high-affinity reco

75 contrast, periodic induction of replication initiator protein DnaA caused oscillations in cell size

76 raction, two binding sites for the bacterial initiator protein DnaA, and a binding site for the DNA-b

77 In bacteria, initiator protein DnaA, bound to specific high- and low-

78 acteria, DNA replication is triggered by the initiator protein DnaA, which has long been suggested to

79 nd processed by an oligomeric complex of the initiator protein DnaA.

80 bile priming apparatus assembled without the initiator protein DnaA.

81 controlling the activity of the replication initiator protein DnaA.

82 inhibiting or activating the DNA replication initiator protein DnaA.

83 DNA synthesis initiated independently of the initiator protein DnaA.

84 replication in bacteria is regulated via the initiator protein DnaA.

85 controls the activity of the DNA replication initiator protein DnaA.

86 minotransferase BCAT and the DNA replication initiator protein DnaA.

87 Recent research on the inactivation of initiator protein (DnaA) and depletion of DnaA pools by

88 structures independently of the replication initiator protein, DnaA, and thereby facilitates assembl

89 In bacteria the master initiator protein, DnaA, is highly conserved and has two

90 Oligomerization of the initiator protein, DnaA, on the origin of replication (o

91 DNA replication requires the binding of the initiator protein, DnaA, to specific binding sites in th

92 gered during each cell division cycle by the initiator protein, DnaA.

93 ial chromosomes require only one replication initiator protein, e.g., DnaA, most plasmid replicons de

94 irus type 11 (HPV-11) origin recognition and initiator protein E1 and human polymerase alpha/primase

95 The replication initiator protein E1 binds to the origin of replication

96 The bovine papillomavirus replication initiator protein E1 is an origin of replication (ori)-b

97 l transcription factor E2 recruits the viral initiator protein E1 to the origin of DNA replication (o

98 ght to determine whether the affinity of the initiator protein (EBNA1) for its binding sites in the o

99 The RepC initiator protein encoded by pT181 nicks at the origin o

100 The replication initiator proteins encoded by the RC plasmids and single

101 e why DnaA, the bacterial master replication initiator protein, exists in both ATP and ADP forms, des

102 The origin recognition complex (ORC) is an initiator protein for DNA replication, but also effects

103 isolated from Escherichia coli activates the initiator protein for replication in the purified system

104 s: host-encoded DnaA and plasmid-encoded Rep initiator protein for replication initiation.

105 Eukaryotic initiator proteins form origin recognition complexes (OR

106 By contrast, initiator proteins formed solid-like assemblies upon exp

107 ated in eukaryotic replicons is unknown, but initiator proteins from a handful of eukaryotic viruses

108 conserved among geminivirus AL1 proteins and initiator proteins from other rolling circle systems are

109 chromosome copy number and inhibition of the initiator protein functions by PprA strongly suggest tha

110 o function as origins of DNA replication, no initiator protein has yet been identified in the set of

111 om cell extracts with a putative replication initiator protein, human ORC2L.

112 II and inhibits the activity of drDnaA, the initiator protein in D. radiodurans.

113 cognition complex (ORC) is a DNA replication initiator protein in eukaryotes that defines the localiz

114 gnition complex (ORC) is the DNA replication initiator protein in eukaryotes.

115 d to bind and modulate the viral replication-initiator protein in vitro and in Saccharomyces cerevisi

116 Replication initiator proteins in bacteria not only allow DNA replic

117 he superfamily of rolling-circle replication initiator proteins in general and the parvovirus replica

118 ructures may be applicable to the binding of initiator proteins in other single-stranded DNA priming

119 Replication initiator proteins in other systems, including those of

120 ate that Epsin1 destabilizes condensation of initiator proteins in the absence of ubiquitin.

121 x virus 1 UL9 protein, the viral replication-initiator protein, in a yeast two-hybrid screen.

122 tric replication of plasmids, acting with an initiator protein, in our case RepD.

123 unctions characteristic of a DNA replication initiator protein, including origin-specific DNA binding

124 rate that under certain conditions the RepA1 initiator protein inhibits plasmid replication.

125 tead of a common surface of interaction with initiator proteins, interestingly, DnaB helicase appears

126 cognition of the replication origin (ori) by initiator protein is a recurring theme for the regulated

127 ociated motifs in a conjugative DNA transfer initiator protein is rare.

128 Following termination, the initiator protein is released with a short oligonucleoti

129 The relationship of RepA to other known initiator proteins is also discussed.

130 The activity of DnaA and several plasmid initiator proteins is stimulated by ATP binding.

131 A unifying characteristic of DNA replication initiator proteins is their distinctive AAA+ nucleotide-

132 h cells show a specific defect in loading of initiator proteins Mcm4, Mcm7, and to a lesser degree, M

133 How do initiator proteins meet these competing demands?

134 -positive bacteria requires the unwinding of initiator protein-nicked plasmid DNA by the PcrA helicas

135 replication in vitro, dependent on the viral initiator protein NS1, using plasmid forms of the 5' ori

136 These are resolved by the viral initiator protein, NS1, but mechanisms employed at the t

137 The minute virus of mice initiator protein, NS1, excises new copies of the left v

138 The viral initiator protein, NS1, then excises individual genomes

139 TrfA, the replication initiator protein of broad-host-range plasmid RK2, was t

140 on the regulation of dnaA which encodes the initiator protein of DNA replication.

141 DnaA protein, the initiator protein of E. coli chromosomal replication, ca

142 -terminal domain IV of the host-encoded DnaA initiator protein of Escherichia coli interact physicall

143 monomeric and the dimeric forms of the RepE initiator protein of F factor together promote pairing o

144 RepA, the initiator protein of plasmid P1, binds to multiple sites

145 ligation activities of RepC, the replication initiator protein of plasmid pT181, in plasmid sized and

146 monomeric biologically active form of the pi initiator protein of plasmid R6K as a complex with a sin

147 The replication initiator protein of pT181, RepC, has origin-specific ni

148 cases also physically interact with the RepC initiator protein of pT181.

149 ing domain of SV40 T antigen (T-ag-obd), the initiator protein of the SV40 virus, and cognate and non

150 tructure of the catalytic domain of Rep, the initiator protein of tomato yellow leaf curl virus.

151 Here, we show that the initiator protein of Vibrio cholerae specific to chromos

152 is analogous to their role in activating the initiator proteins of other organisms.

153 In budding yeast, the eukaryotic initiator protein ORC (origin recognition complex) binds

154 Did the primary control involve only initiator protein-ori DNA interaction or did it also inv

155 erichia coli that needs only one replication initiator protein (origin recognition protein) called Dn

156 as strictly dependent on the plasmid-encoded initiator protein pi and on the host-encoded initiator D

157 Individually, these sites do not bind to initiator protein pi but access it by DNA looping-mediat

158 t only near the primary binding sites of the initiator protein pi but also at a distance, caused by p

159 origin of plasmid R6K requires the specific initiator protein pi for initiation of replication.

160 The replication initiator protein pi of plasmid R6K is known to interact

161 lements of the plasmid are a multifunctional initiator protein pi, and sequence-related DNA target si

162 The replication initiator protein, pi, plays an essential role in the in

163 hyperactive variants of plasmid R6K-encoded initiator protein, pi.

164 s 7 iterons that bind to the plasmid-encoded initiator protein, pi.

165 In all organisms, initiator proteins possessing AAA+ (ATPases associated w

166 indings suggest that liquid-like assembly of initiator proteins provides an optimal catalytic platfor

167 As expected for an initiator protein, recombinant drDnaA showed sequence-sp

168 orm of the Escherichia coli DnaA replication initiator protein remodels the chromosomal origin of rep

169 A multifunctional replication initiator protein (Rep) is indispensable for the precise

170 PORTANCE Nuclear activity of the replication initiator protein (Rep) of geminiviruses is essential fo

171 anded origin of replication by a replication initiator protein (Rep).

172 ding sites (iterons) for the plasmid-encoded initiator protein RepA.

173 During replication of the plasmid pT181, the initiator protein RepC is modified by the addition of an

174 by controlling the synthesis of its dimeric initiator protein RepC/C and by inactivating the protein

175 The synthesis of the pT181 initiator protein (RepC) is regulated by antisense RNAs,

176 The replication initiator protein RepD encoded by the Staphylococcus chl

177 The replication initiator protein RepD recruits the Bacillus PcrA helica

178 ication of certain plasmids, acting with the initiator protein (RepD) that binds to and nicks the dou

179 The initiator protein (RepE) of F factor, a plasmid involved

180 Replication initiator proteins (Reps) from the HUH-endonuclease supe

181 pillomavirus E1 protein is a multifunctional initiator protein responsible for preparing the viral DN

182 Analysis of the 3 Orc1/Cdc6 initiator proteins showed a uniformity of cellular abund

183 present, Epsin1 binds to both ubiquitin and initiator proteins, stabilizing condensation.

184 ation via negative regulation of replication initiator proteins, such as CDC6, is key to maintenance

185 s 40 or bovine papilloma virus--in which the initiator protein, T antigen, or E1 protein alone, unwin

186 The binding of one such protein, the initiator protein TFII-I, to the initiation region of HI

187 iochemical attributes of mutations in the pi initiator protein that caused loss of negative control o

188 a previously unrecognized candidate archaeal initiator protein that is distantly related to eukaryoti

189 Initiation of this replication occurs via an initiator protein that nicks one DNA strand at the doubl

190 Plasmids of the pT181 family encode initiator proteins that act as dimers during plasmid rol

191 adeno-associated virus (AAV) are replication initiator proteins that bind the viral replicative-form

192 poptotic members of the Bcl-2 family include initiator proteins that contain only BH3 domains and dow

193 s (BPV-1) and Simian virus 40 (SV40) are the initiator proteins that recognize and melt their respect

194 ed origins, which serve as binding sites for initiator proteins that recruit the replicative machiner

195 d because of the conserved structure of AAA+ initiator proteins these findings raise the possibility

196 bacteria, which typically use chaperones or initiator proteins to initiate amyloid assembly, our fin

197 This promptly recruits Sld3-Sld7 replication initiator proteins to pericentromeric replication origin

198 smid RK2 is dependent on the plasmid-encoded initiator protein, TrfA, and the RK2 origin of replicati

199 teraction of the herpes simplex virus type-1 initiator protein (UL9) with oriS, one of the viral orig

200 iption factors and a chromosomal replication initiator protein were also found.

201 the 10 genes coding for Orc-Cdc6 replication initiator proteins were essential, while a third (orc7),

202 The repA gene encodes an initiator protein, whereas repB and repC encode proteins

203 actors: a specific DNA sequence (origin), an initiator protein which binds to the origin, a helicase

204 of replication by promoting interactions of initiator proteins with origin sequences.

205 f the Epstein-Barr virus-encoded DNA binding initiator protein, ZTA.