ライフサイエンスコーパス: innate

1 t) or PBS for 4 consecutive days to evaluate innate airway allergic inflammation.

2 te lymphoid cell (ILC2) activation to induce innate allergic inflammation.

3 es are an essential source of IL-12 for both innate and adaptive IFNgamma production, and inhibit fol

4 However, the function and regulation of both innate and adaptive immune cells in human WAT under cond

5 ffect of CD40L-overexpressing CAR T cells on innate and adaptive immune cells, and provide a rational

6 le dynamically reprogramming the function of innate and adaptive immune cells.

7 Innate and adaptive immune responses that prime myeloid

8 LAs) are cell surface proteins that regulate innate and adaptive immune responses to viral infection

9 splay attenuated airway hyperresponsiveness, innate and adaptive immune responses, and type 2 cytokin

10 nating infected cells and by mobilizing both innate and adaptive immune responses.

11 ted with the development of inflammation and innate and adaptive immune responses.

12 pism and is subjected to the control of host innate and adaptive immune responses.

13 lex (LUBAC) is an essential component of the innate and adaptive immune system.

14 ents in our understanding of the role of the innate and adaptive immune systems in the pathogenesis o

15 icles and involve activation of cells of the innate and adaptive immune systems, with pivotal roles f

16 ines are small proteins secreted by cells in innate and adaptive immune systems.

17 rleukin-6 (IL-6) is a cytokine with critical innate and adaptive immunity functions.

18 As with the host microbiome, their effect on innate and adaptive immunity in health and disease with

19 th a few other neural functions, induce both innate and adaptive immunity in NTNBC.

20 xpansion, highlighting the parallels between innate and adaptive lymphocytes, with a particular focus

21 tors in regulating specification programs of innate and adaptive lymphocytes.

22 In this respect, innate and innate-like cells with unique immune properti

23 Animals exhibit innate and learned preferences for temperature and humid

24 avian viruses is important in understanding innate antiviral defenses in birds.IMPORTANCE Birds are

25 olyubiquitination of MAVS and thus shuts off innate antiviral immune response.

26 es OTUD3 and thus allows timely induction of innate antiviral immunity.

27 Expression of viral genes and activation of innate antiviral responses during infection result in an

28 These initially innate behaviors depend critically upon coordinated deve

29 with internal state to elicit both variable innate behaviours and reinforced behaviours that may pro

30 therapeutic and diagnostic tools due to the innate biological ability of nucleic acids to identify t

31 ne profiling revealed an overall increase in innate cell lineages, with a concomitant reduction in T

32 Rs) provide critical molecular links between innate cells and adaptive immune responses.

33 cies, receptor repertoires, and functions of innate cells in the oral and gut mucosa of infants.

34 Unsupervised analysis of the innate compartment (CD3CD19 cells) identified 5 CD11c cl

35 the propensity to overeat may have a strong innate component embedded in reward circuits.

36 he language network, providing evidence that innate connectivity instructs the later refinement of co

37 However, to what extent innate cues from DCs dictate transcriptional changes in

38 M6 expression in DC enhances proinflammatory innate cytokine production to promote an altered Th2 imm

39 ives of the immunomodulatory and antibiofilm innate defense regulator peptide (IDR)-1018 based on thr

40 ted genes correlates a nanoscale Cu-enhanced innate disease response to reduced pathogenicity and inc

41 Here we found an innate DNA damage response mechanism that is evident dur

42 te lymphoid cells (ILC2) are tissue-resident innate effector cells that can mediate airway inflammati

43 ding their deficiencies in responsiveness to innate environmental cues, FcRgamma(-) NK cells responde

44 to survive ART monotherapy may relate to an innate growth bistability phenomenon whereby a fraction

45 Like other innate human senses, the complexity perception cannot be

46 However, excessive innate immune activation can exaggerate disease.

47 cluding plant sterols, interact with hepatic innate immune activation promoted by products of gut bac

48 associated with both central and peripheral innate immune activation.

49 rmative transcriptome module specialized for innate immune and neutrophil functions.

50 e in part to pregnancy-induced alteration of innate immune cell frequencies and cytokine expression.

51 characterized by a significant activation of innate immune cells (DPA+) or not.

52 eal a new anti-inflammatory role for JAK3 in innate immune cells and show that the underlying signali

53 d, including the activation and functions of innate immune cells and the emerging innate properties a

54 ic landscape of central nervous system (CNS) innate immune cells contributing to oxidative stress is

55 tiple inflammatory cytokines are produced by innate immune cells during SARS-CoV-2 infection, we foun

56 Monocytes are innate immune cells essential for host protection agains

57 ant macaques through alterations of resident innate immune cells giving rise to chronic inflammation

58 profiling of oxidative stress-producing CNS innate immune cells identified a core oxidative stress g

59 Microglia are primary innate immune cells in the brain although their direct i

60 Dendritic cells (DCs) and other innate immune cells patrol the oral mucosa for infecting

61 hracis PGA is recognized less effectively by innate immune cells than PGAs from nonpathogenic Bacillu

62 tinal mucosal tissue and are among the first innate immune cells that encounter human immunodeficienc

63 Macrophages, innate immune cells that reside in all organs, defend th

64 al peptidoglycan (muramyl peptides) activate innate immune cells through nucleotide-binding oligomeri

65 her PGAs, we compared the responses of human innate immune cells to B. anthracis PGA and PGAs from no

66 ve elevated infection risk, opioids activate innate immune cells, and opioids attenuate inflammation

67 ys that restrict viral replication, activate innate immune cells, and regulate adaptive immunity.

68 ath), but others are more unique features of innate immune cells, enabling them to fulfill their spec

69 ncreased expression of inflammatory genes in innate immune cells, potentially explaining the link bet

70 ifies autoimmune pathology via activation of innate immune cells.

71 creting cells; and (ii) elevated presence of innate immune cells.

72 These findings support the use of CD47 as an innate immune checkpoint to mitigate IBMIR for enhanced

73 (15%) a combined immunodeficiency, 3 (3%) an innate immune defect, and 2 (2%) bone marrow failure.

74 Inflammasomes are important sentinels of innate immune defence that are activated in response to

75 duces interferon beta expression to initiate innate immune defenses.

76 that m(6)A serves as a molecular marker for innate immune discrimination of self from non-self RNAs.

77 zation as well as through the recruitment of innate immune effector functions.

78 ighlights the need to understand the role of innate immune effectors in the complex interactions betw

79 aits, we tested how diet composition affects innate immune function, body mass and moult separately a

80 clusters associated with MPS maturation and innate immune function.

81 Altered innate immune gene expression in Lrrk2 knockout (KO) mac

82 Exomic studies have demonstrated that innate immune genes exhibit an even higher degree of var

83 We assessed innate immune indices (haptoglobin, nitric oxide and ovo

84 We sampled blood and measured five innate immune indices from 286 Common Bulbuls Pycnonotus

85 , loss of Adar RNA editing activity leads to innate immune induction, indicating that Drosophila Adar

86 stablish a granzyme- and granulysin-mediated innate immune mechanism exerted by gammadelta T cells to

87 lthy volunteers, demonstrating that impaired innate immune mechanisms following DEP exposure are also

88 clear, however, whether host species possess innate immune mechanisms that can neutralize pore-formin

89 Although previous studies have shown that innate immune memory induced by beta-glucan confers prot

90 ysaccharide, contributes to the induction of innate immune memory, which is associated with long-term

91 ifically to reinfection, a phenomenon called innate immune memory.

92 c efficacy of a microbial-based stimulus for innate immune mobilization depends on the correct select

93 direct activities such as virus assembly and innate immune modulation.

94 tigated the immune-regulatory effects of the innate immune molecule, nucleotide-binding oligomerizati

95 ucture of lipid A (endotoxin) determines the innate immune outcome during infection, the ability to m

96 P-AMP synthase interferon genes (cGAS-STING) innate immune pathway.

97 ed by environmental exposures that stimulate innate immune pathways capable of promoting or protectin

98 howed decreased ubiquitylation and activated innate immune pathways.

99 Cs) in the tumor and activates complementary innate immune pathways.

100 ss transcriptomics identified neurotoxic CNS innate immune populations and may enable discovery of se

101 f pathogens by Kupffer cells is an important innate immune process in the liver.

102 Lipocalin-2 (Lcn2) is an innate immune protein elevated by several orders of magn

103 A set of germline-encoded innate immune receptors detect microbial DNA in various

104 Innate immune receptors such as toll-like receptors (TLR

105 role of specific immune cell types, cognate innate immune receptors, and inflammatory cytokines on p

106 g cancer cells have the potential to amplify innate immune response and activate antitumor adaptive r

107 t in murine xenogeneic model, activating the innate immune response and increasing tumor infiltrating

108 Indicators of the neonatal innate immune response are associated with risk of ASD,

109 ion of host genes related to translation and innate immune response could contribute to differential

110 endogenous dsRNA formation and a deleterious innate immune response during mammalian hematopoietic de

111 gnificantly increased, whereas expression of innate immune response genes are significantly decreased

112 t how macrophages fit into the context of an innate immune response in whole animals with multiple ce

113 numbers within dystrophic muscle, or that an innate immune response is required for effective donor c

114 vestigate the molecular underpinnings of the innate immune response of the larvae to the pathogen.

115 eveal a striking divergence in a fundamental innate immune response pathway in AMs and establish a fr

116 in induction of the earliest aspects of the innate immune response to Aspergillus fumigatus.

117 taphylococcus aureus (MRSA) and bolsters the innate immune response to infection.

118 kocytes, play an important role in the early innate immune response to Mycobacterium tuberculosis inf

119 Human neutrophils are critical for the innate immune response to S. aureus infection.

120 IFN-beta is a key component of the innate immune response to viral infection.

121 M family proteins play integral roles in the innate immune response to virus infection.

122 ed lung tissues show a massively upregulated innate immune response with signatures of nuclear factor

123 by mycoplasma components that stimulate the innate immune response with the same basic regulatory me

124 use several mechanisms to modulate the host innate immune response, and these likely contribute to t

125 Macrophages, an important component of the innate immune response, are a key regulator of intestina

126 in microglia that are not associated with an innate immune response.

127 virus replication and/or by stimulating the innate immune response.

128 ellular pathogen products and initialize the innate immune response.

129 ce, suggesting a role for TLR sensing in the innate immune response.

130 eliminate the danger signal and inhibit the innate immune response.

131 ing activities is required for PARPi-induced innate immune response.

132 (Lpro) affects several pathways of the host innate immune response.

133 d therefore may increase the efficacy of the innate immune response.

134 suggests that cholesterol metabolism impacts innate immune responses against infection.

135 cle, Chlamydia must evade both intracellular innate immune responses and adaptive cytotoxic T cell re

136 ght regulation of NEMO is essential for host innate immune responses and for maintenance of homeostas

137 study reveals a critical role of Hv1 during innate immune responses and places this channel as a key

138 ern recognition receptor that modulates host innate immune responses and protects from inflammation,

139 chanistically, we show that acetate enhances innate immune responses by acting on both neutrophils an

140 , participate in the induction of protective innate immune responses during invasive aspergillosis.

141 hich could possibly affect the TLR-triggered innate immune responses in malaria patients.

142 demonstrating the likely critical role these innate immune responses play in early mucosal HIV replic

143 Innate immune responses rely on rapid and precise gene r

144 Prior studies have identified specialized innate immune responses that are active in the intestina

145 data indicate that C6(-/-) mice have reduced innate immune responses that result in less organ injury

146 hanistic insights into the differential host innate immune responses to highly pathogenic arenavirus

147 ecognized as modulators of both adaptive and innate immune responses, as well as players in an import

148 where it is protected from host cytoplasmic innate immune responses.

149 pattern recognition receptors that initiate innate immune responses.

150 ic activity of lysozyme, virulence, and host innate immune responses.

151 ic naivete of the host population, and muted innate immune responses.

152 the biology of the intestinal epithelium and innate immune responses.

153 cantly potentiate ionizing radiation-induced innate immune responses.

154 onclude that ZIKV permissiveness, as well as innate immune responsiveness of human decidual cells, ar

155 Importantly, viral activation of innate immune sensing or the endoplasmic reticulum (ER)

156 The innate immune sensor NLRP3 assembles an inflammasome com

157 the released mtRNAs can directly bind to the innate immune sensor protein kinase R (PKR).

158 ZBP1 is unique among innate immune sensors because of its N-terminal Zalpha1

159 Dengue virus (DENV) infection disrupts host innate immune signaling at various checkpoints.

160 standing of how rotavirus (RV) subverts host innate immune signaling has greatly increased over the p

161 ploy strategies to prevent the activation of innate immune signaling in infected cells.

162 ing via disruption of USP7 interactions with innate immune signaling proteins TRAF3 and TRAF6, and th

163 oding (lnc) RNA that activates non-canonical innate immune signaling upon detection of the dsRNA-bind

164 outcome in AGMs was associated with aberrant innate immune signaling, complement dysregulation, Th2 s

165 eudokinase 3 (TRIB3), negative regulators of innate immune signaling, in HT-29 intestinal epithelial

166 epresents a new modulatory axis of STING and innate immune signalling at the ER membrane.

167 MED1 to form a complex capable of modulating innate immune signalling through the cGAS-STING pathway.

168 One potential limitation of using HIEs for innate immune studies is the relative lack of responsive

169 Here, we describe a mechanism by which the innate immune system allows rapid quality check of absor

170 Natural killer (NK) cells belong to the innate immune system and contribute to protecting the ho

171 re activated, how infection is sensed by the innate immune system and how intracellular signalling sy

172 of BDG can still be recognised by the host's innate immune system and persistent BDG antigenaemia, in

173 lement system is an intricate cascade of the innate immune system and plays a key role in microbial d

174 Neutrophils are important cells of the innate immune system and the major leukocyte subpopulati

175 elicidin LL-37 serves a critical role in the innate immune system defending bacterial infections.

176 Chronic activation of the innate immune system drives inflammation and contributes

177 immune activation (MIA) disrupts the central innate immune system during a critical neurodevelopmenta

178 ecognition of influenza A virus (IAV) by the innate immune system triggers pathways that restrict vir

179 ect itself from several aspects of the human innate immune system, and control its iron homeostasis.

180 ments that target specific components of the innate immune system.

181 icrobials and protects the bacteria from the innate immune system.

182 Oxidative stress is a central part of innate immune-induced neurodegeneration.

183 Innate immune-mediated programmed cell death (pyroptosis

184 major depressive disorder were enriched for innate immune-related functions, coded for nonrandom pro

185 In contrast, prevention of cell death and innate immunity after CI+Txp requires inhibition of both

186 Myeloid cells are a vital component of innate immunity and comprise monocytes, macrophages, den

187 nctional insights into HC1 as a regulator of innate immunity and further elucidate the role of HC.HA

188 ne-active peptides, naturally encountered in innate immunity and infection, could have important medi

189 Both innate immunity and inflammatory disorders hinge on the

190 utbreak, supported by its potential to boost innate immunity and initial epidemiological analyses whi

191 categorized as a new adipokine cross-linking innate immunity and metabolic disorders including obesit

192 ranscriptomic analysis revealed induction of innate immunity and phagocytotic pathways in presymptoma

193 mmunity and induction of programs related to innate immunity and response to danger signals triggered

194 endently associated with differences in both innate immunity and the stool microbiome in a biogeograp

195 pportunities to study the systems biology of innate immunity and to determine how sustained ISG upreg

196 f animal physiology, yet roles in regulating innate immunity are relatively unexplored.

197 in neutrophilia, suggesting that exaggerated innate immunity contributes to age-enhanced mortality to

198 atocytes injury, the recruitment of cells of innate immunity exerts a mechanistic role in disease pro

199 sed, uninfected (HUU) children, with altered innate immunity hypothesized to be a cause.

200 ive immunity, indicating a critical role for innate immunity in endometrial control of C. trachomatis

201 s the evolution of this field of research on innate immunity in obesity and metabolic perturbation, a

202 ock as a potential strategy to suppress host innate immunity is not well understood.

203 inflammatory signaling downstream of various innate immunity receptors.

204 omplement proteins are ancient components of innate immunity that have emerged as crucial regulators

205 Innate immunity to nucleic acids forms the backbone for

206 l oxidase 2, related to thyroid function and innate immunity) genes and, in the Amazon, the gene enco

207 lowed the acquisition of STING into metazoan innate immunity, and determine the structure of a full-l

208 will shed light on the origins of regulated innate immunity, and may have relevance to our understan

209 et-neutrophil interactions are important for innate immunity, but also contribute to the pathogenesis

210 ment for mitochondrial processes, as well as innate immunity, chronic inflammation, cell cycle, circa

211 As a marker of activation of innate immunity, high PCT levels affect clinical diagnos

212 asal epithelial cells with genes involved in innate immunity, highlighting the cells' potential role

213 Trained innate immunity, induced via modulation of mature myeloi

214 (PTX3) is an essential component of humoral innate immunity, involved in resistance to selected path

215 brane receptors important for axon guidance, innate immunity, synapse development, and synaptic plast

216 ment of mice with an ATXN2 ASO also modified innate immunity, the complement system and lysosome/phag

217 to cell cycle arrest, genotoxic stress, and innate immunity.

218 erived nucleic acids are crucial signals for innate immunity.

219 aspergillosis correlates with impairments in innate immunity.

220 cyclic dinucleotide signalling in mammalian innate immunity.

221 of importance for complement recognition and innate immunity.

222 -inducible factor (HIF) in the regulation of innate immunity.

223 their functional coordination in vertebrate innate immunity.

224 ay yield new insights into the regulation of innate immunity.

225 f interferons, a key component in vertebrate innate immunity.

226 presentation, which may aid viral evasion of innate immunity.IMPORTANCE Human leukocyte antigens (HLA

227 displayed elevated peripheral production of innate inflammatory cytokines, including IL-1beta, IL-6,

228 oxia through transcriptional rewiring toward innate/inflammatory response programs.

229 Despite being prolific innate killers, NK cells are also key helper cells in an

230 reventing the development of innate (NK) and innate-like adaptive lymphocytes (iNKT, MAIT, and Vdelta

231 ontains potentially beneficial self-reactive innate-like B cell specificities that may facilitate the

232 t dampen DC antigen presentation and recruit innate-like CD8(+) T cells.

233 In this respect, innate and innate-like cells with unique immune properties, such as

234 We recently showed that MP cells exert innate-like effector function during host defense, but w

235 ls) that exhibit hallmarks of activation and innate-like functional properties.

236 overexpressed KLRB1 (CD161) and displayed an innate-like low cytotoxic state, with low clonal expansi

237 ant natural killer T (iNKT) cells are a rare innate-like lymphocyte population that recognizes glycol

238 Invariant natural killer T (iNKT) cells are innate-like lymphocytes with unique signaling requiremen

239 Interestingly, enhanced innate-like pathways and characteristics develop progres

240 findings identify a novel role for FSTL-1 in innate lung immunity to bacterial infection, suggesting

241 Here, we review advances in understanding of innate lymphocyte biology with a focus on skin disease a

242 mmarize the evidence for clonal expansion in innate lymphocytes, which has primarily been observed in

243 l-specific phenotype did not extend to other innate lymphocytes.

244 on CD34(+) cell differentiation into CD56(+) innate lymphocytes.

245 ucoinflammatory airway disease, deficient in innate lymphoid (Il2rg knockout mice [Il2rg (KO)]), adap

246 ously reported the selective loss of group 3 innate lymphoid cell (ILC) number and function in a Dock

247 P and IL-33 synergistically promoted group 2 innate lymphoid cell (ILC2) activation to induce innate

248 we demonstrate that helminth-induced group 2 innate lymphoid cell (ILC2) responses are exaggerated in

249 zation and straightforward identification of innate lymphoid cell 2 progenitor populations.

250 Increased permeability, IL-33 levels, type 2 innate lymphoid cell activation, and T(h)2 cell differen

251 7(+/-)CD94(+)NKp80(-)) NKDIs promoted non-NK innate lymphoid cell differentiation at the expense of N

252 During early pregnancy, decidual innate lymphoid cells (dILCs) interact with surrounding

253 permanently "time stamp" NK cells and type 1 innate lymphoid cells (ILC1s) to characterize the dynami

254 Group 2 innate lymphoid cells (ILC2) are tissue-resident innate

255 Type-2 innate lymphoid cells (ILC2s) are a potent source of T-h

256 Human type 2 innate lymphoid cells (ILC2s) are identified by coupled

257 Group 2 innate lymphoid cells (ILC2s) are implicated in host def

258 plasia phenotype that is dependent on type 2 innate lymphoid cells (ILC2s).

259 ady-state activation hubs containing group 3 innate lymphoid cells (ILC3) that continuously produce i

260 In two independent cohorts, we found that innate lymphoid cells (ILCs) were depleted in the blood

261 the unique characteristics of skin-resident innate lymphoid cells (ILCs).

262 Natural killer (NK) cells are innate lymphoid cells being explored as they engage tumo

263 osinophils, mast cells, T(H)2 cells, group 2 innate lymphoid cells, and antigen-presenting cells; and

264 sed together with CD14(+) CD16(+) monocytes, innate lymphoid cells, and natural killer cells.

265 In natural killer (NK) cells and other innate lymphoid cells, competent enhancers are primed du

266 aligned with pathways associated with type 2 innate lymphoid cells, monocytes, neutrophil trafficking

267 pport tissue homeostasis and repair, such as innate lymphoid cells.

268 bacterial macrophage activation, whereas the innate lymphoid system contributes to MCM, mucin product

269 Ultimately, apoptosis is an important innate mechanism by which cells counter viruses at local

270 o enhancers characterizes the acquisition of innate memory in activated NK cells and macrophages.

271 These innate metabolic changes have been compared to aerobic g

272 enance of the autophagy-inflammasome axis in innate murine immune cells.

273 e of one single murine dermal cell type, the innate neonatal-derived IL-17 producing gammadelta T (Tg

274 ial disease by preventing the development of innate (NK) and innate-like adaptive lymphocytes (iNKT,

275 ing inflammation; and lack interference with innate or adaptive immunity.

276 persistent increase in the abundance of the innate pathogen sensor NOD1 precipitated large changes i

277 In addition, C(18)-SMe(2)(+) activates innate plant defense.

278 ions of innate immune cells and the emerging innate properties and modulatory roles of the fibroblast

279 for red blood cell polymorphisms that confer innate protection against severe disease.

280 Further profiling revealed that these innate, public Vgamma9Vdelta2(+) T cells underwent an im

281 The effect of the COX pathway on innate pulmonary inflammation induced by protease-contai

282 he complex interaction between the virus and innate receptors that may underlie disease pathogenesis.

283 Approaches that enable innate repair mechanisms hold great potential for tissue

284 killer (NK) cells are key effector cells of innate resistance capable of destroying tumors and virus

285 brane (OM) of gram-negative bacteria confers innate resistance to toxins and antibiotics.

286 action are up to >20:1 ortho/para, while the innate selectivities for phenols and anilines are approx

287 results unveil how telomere stress increases innate sensing and adaptive anti-tumor immunity and prov

288 of action by those drugs including inducing innate sensing and limiting immunosuppressive factors in

289 Inflammation is triggered by stimulation of innate sensors that recognize pathogens, chemical and ph

290 gs provide a framework for understanding how innate sensory cues are processed to elicit adaptive beh

291 , understanding the mechanism(s) driving the innate sex bias in neutrophil bactericidal capacity coul

292 hts the contributions of CR3, C3, and ROS to innate sex bias in the neutrophil response to S. aureus

293 ssociated with poor prognosis, whereas early innate signaling and Th1-skewed immunity are important f

294 By contrast, key innate signaling responses previously associated with pa

295 As with any field that delves deeply into innate signaling, obstacles of reagent purity may be a c

296 tor (TNF)-alpha, post-effector cells acquire innate signatures to adopt regulatory functions that may

297 ght to assess in vivo immune responses to an innate stimulus and compare responsiveness between healt

298 Here, we provide a concise overview of the innate system in cancer and recent advances in the field

299 ributions via organ culture, highlighted the innate tendon environment as the driver of scarless heal

300 eptibility to infection, early pathogenesis, innate viral control, adaptive immune responses or the b