ライフサイエンスコーパス: inner cell

1 een previously classified as either outer or inner cells.

2 rmal wall extensibility to the elasticity of inner cells.

3 l death and promotes survival and release of inner cells.

4 ith marginal cells proliferating faster than inner cells.

5 TE derives from outer cells whereas ICM from inner cells.

6 ve curvature of the membrane surrounding the inner cell and the negative curvature of the cytoplasmic

7 ve Rac1 additionally blocks the apoptosis of inner cells and cavitation, indicating that the spatiall

8 eral ring of primarily viable cells, whereas inner cells are mostly necrotic.

9 it embeds in the membrane that surrounds the inner cell but not in the cytoplasmic membrane of the ou

10 to as intermediate cells, share features of inner cells but exhibit different dynamic behaviors and

11 All inner cells coexpress lineage markers such as Nanog and

12 mechanism, based on a minimal number of four inner-cell contacts in the ICM, which activates Oct4 in

13 Caulobacter crescentus and localizes to the inner cell curvature.

14 helical structure that colocalizes with the inner cell curvatures beneath the cytoplasmic membrane.

15 A transient inner cell death phenotype was detected in their develop

16 The inner cell mass arises from inner cells during subsequent developmental stages and c

17 The shortest distance between the set of inner cells (E3.25, E3.5 and E4.5) and the ESCs is betwe

18 es show replacement of outer cell fates with inner cell fates.

19 ion, outer cells become trophectoderm, while inner cells form the inner cell mass (ICM), later differ

20 ypodermal cell divides periclinally with the inner cell giving rise to the sporogenous archesporial c

21 (pre-LC) and PB external lateral-inner (PBel-inner) cell groups of the dorsolateral pons.

22 is unknown how biomechanical forces allocate inner cells in vivo.

23 Our results indicate that inner cells intercalate by first wedging between the bas

24 projections of phase-locking neurons in the inner cell layer (ICL) of the ELL.

25 All but one neuron in the inner cell layer of the medial zone responded exclusivel

26 The inner cell layer of the outer integument also produces a

27 ncluding its reserve HFSCs and SC-inhibitory inner cell layer, is lost.

28 the free diffusion of molecules between the inner cell layers of the root and the outer environment.

29 al that is transmitted from the outer to the inner cell layers of the root.

30 tor and, in the retina, is released from the inner cell layers.

31 3 signaling is also required to maintain the inner cell mass (from which stem cells are derived).

32 ate into trophectoderm (future placenta) and inner cell mass (future fetus).

33 ring mammalian preimplantation, cells of the inner cell mass (ICM) adopt either an embryonic or an ex

34 f geminin in the mouse prevents formation of inner cell mass (ICM) and causes premature endoreduplica

35 distinct pluripotent states representing the inner cell mass (ICM) and epiblast embryos.

36 is expressed in the pluripotent cells of the inner cell mass (ICM) and epiblast of the peri-implantat

37 cell blastomeres that will contribute to the inner cell mass (ICM) and polar trophectoderm and undert

38 cells are pluripotent cells derived from the inner cell mass (ICM) and the epiblast, and have been su

39 omeres that will generate both the embryonic inner cell mass (ICM) and the supportive trophectoderm (

40 Communication between the inner cell mass (ICM) and the trophoblast layer of the b

41 Expanded blastocysts with existent inner cell mass (ICM) and trophectoderm (TE) cells under

42 ent, genesis of the first two cell lineages, inner cell mass (ICM) and trophectoderm (TE), is depende

43 ormation of the blastocyst consisting of the inner cell mass (ICM) and trophectoderm (TE).

44 loping into blastocysts with an identifiable inner cell mass (ICM) and trophectoderm (TE).

45 irections of differential expression between inner cell mass (ICM) and trophectoderm (TE).

46 the spatial organization and segregation of inner cell mass (ICM) and trophectoderm epithelium (TE)

47 IP in mouse embryonic stem (ES) cells and in inner cell mass (ICM) and trophectoderm of cultured blas

48 er positions of the embryo, establishing the inner cell mass (ICM) and trophectoderm.

49 lantation development, the generation of the inner cell mass (ICM) and trophoblast lineages comprises

50 Pluripotent cells in the inner cell mass (ICM) are the descendants of totipotent

51 g early murine embryogenesis, cells from the inner cell mass (ICM) can be specified in epiblast (Epi)

52 This analysis revealed that inner cell mass (ICM) cells have unrestricted developmen

53 ells are generally derived by the culture of inner cell mass (ICM) cells, they are often assumed to b

54 ripotent human ES cells to those of isolated inner cell mass (ICM) cells.

55 expression is restricted to the pluripotent inner cell mass (ICM) cells.

56 The size of the inner cell mass (ICM) compartment is not reduced, howeve

57 In the mouse blastocyst, some cells of the inner cell mass (ICM) develop into primitive endoderm (P

58 f the mouse embryo distinguishes pluripotent inner cell mass (ICM) from differentiating trophectoderm

59 ls are trophectoderm (TE) precursors and the inner cell mass (ICM) gives rise to the embryo.

60 t-fertilization (dpf), and restricted to the inner cell mass (ICM) in 128-256 cell blastocysts (6dpf)

61 gregation of the trophectoderm (TE) from the inner cell mass (ICM) in the mouse blastocyst is determi

62 mation of trophectoderm (TE) and pluripotent inner cell mass (ICM) is one of the earliest events duri

63 traploid ESCs were able to contribute to the inner cell mass (ICM) just as diploid ESCs tagged with G

64 formation of the trophectoderm (TE) and the inner cell mass (ICM) lineages during preimplantation de

65 Specification of the trophectoderm (TE) and inner cell mass (ICM) lineages in the mouse blastocyst c

66 Genesis of the trophectoderm and inner cell mass (ICM) lineages occurs in two stages.

67 ed that Csn8 is predominantly present in the inner cell mass (ICM) of E3.5 blastocyst and is widely e

68 r is activated in both the trophectoderm and inner cell mass (ICM) of embryos at embryonic day 3.5 vi

69 ine is distinct from both human PSCs and the inner cell mass (ICM) of human blastocysts.

70 Here we show that the inner cell mass (ICM) of Mbd3-deficient blastocysts fail

71 However, the inner cell mass (ICM) of mouse preimplantation blastocys

72 A subset of cells within the inner cell mass (ICM) of the blastocyst does not respond

73 le inner cells retain pluripotency to become inner cell mass (ICM) of the blastocyst.

74 ent epiblast precursors are specified in the inner cell mass (ICM) of the early blastocyst in a 'salt

75 The inner cell mass (ICM) of the implanting mammalian blasto

76 Cells of the inner cell mass (ICM) of the mouse blastocyst differenti

77 primitive endoderm (PrE) lineages within the inner cell mass (ICM) of the mouse blastocyst involves i

78 (EPI), the two lineages specified within the inner cell mass (ICM) of the mouse blastocyst stage embr

79 versus pluripotent epiblast (EPI) within the inner cell mass (ICM) of the mouse blastocyst.

80 vel analysis of lineage specification in the inner cell mass (ICM) of the mouse blastocyst.

81 DNA methylation is first established in the inner cell mass (ICM) of the mouse blastocyst.

82 embryonic stem (ES) cells that resembles the inner cell mass (ICM) of the pre-implantation embryo.

83 lose contact of polar trophectoderm with the inner cell mass (ICM) promotes proliferation of undiffer

84 ES cells are derived from mammalian inner cell mass (ICM) tissue that express the Class V PO

85 cell-fate decision, the specification of the inner cell mass (ICM) to primitive endoderm (PE) and epi

86 Within the inner cell mass (ICM), all cells relayed FGF/ERK signals

87 formation of the trophectoderm (TE) and the inner cell mass (ICM), and for repressing primitive endo

88 ial locations in a tight time window to form inner cell mass (ICM), and later epiblast (Epi) and prim

89 X-chromosome inactivation (XCI) in the mouse inner cell mass (ICM), and reactivation of X-linked gene

90 ality is due to a defect in expansion of the inner cell mass (ICM), as Mtb(-/-) blastocysts failed to

91 ifferentiate to either trophectoderm (TE) or inner cell mass (ICM), followed by epiblast (EPI) or pri

92 contributes exclusively to the placenta, and inner cell mass (ICM), from which the embryo develops.

93 me trophectoderm, while inner cells form the inner cell mass (ICM), later differentiating into primit

94 In E3.5 inner cell mass (ICM), SOX2 regulates the ICM-trophectod

95 cells of the embryo proper, derived from the inner cell mass (ICM), undergo only random X inactivatio

96 egregation in the mouse embryo generates the inner cell mass (ICM), which gives rise to the pluripote

97 Here we show that inner cell mass (ICM)-generated cells expressing Blimp1,

98 be reverted to stable human preimplantation inner cell mass (ICM)-like naive states with only WNT, M

99 iptional program and segregating TE from the inner cell mass (ICM).

100 ablishment of the trophectoderm (TE) and the inner cell mass (ICM).

101 yonic stem (ES) cell lines, derived from the inner cell mass (ICM).

102 - blastocyst outgrowths revealed loss of the inner cell mass (ICM).

103 phectoderm (TE) and its segregation from the inner cell mass (ICM).

104 f primed PSCs and shares features with human inner cell mass (ICM).

105 polarized trophectoderm cells from an apolar inner cell mass (ICM).

106 antly reduced cell numbers, first within the inner cell mass (ICM; early blastocyst), and later withi

107 approach (four trophectoderms [TEs] and one inner cell mass [ICM] analyzed per blastocyst; n = 390),

108 of an epithelium enveloping the pluripotent inner cell mass and a fluid-filled lumen, the blastocyst

109 and capable of hatching and forming both an inner cell mass and a trophectoderm.

110 reas another transiently resembles the early inner cell mass and correspondingly gains greater develo

111 rsors for two cell lineages: the pluripotent inner cell mass and differentiating trophectoderm.

112 In mouse embryos, Gdf3 is expressed in the inner cell mass and epiblast, and null mutants frequentl

113 Oct4 expression becomes restricted to the inner cell mass and epiblast.

114 Initial cell lineages that presage the inner cell mass and extra-embryonic trophectoderm are es

115 oteins produced by the developing conceptus (inner cell mass and extraembryonic membranes).

116 therefore acts primarily in construction of inner cell mass and germ cell states rather than in the

117 Mouse Nanog is expressed in the inner cell mass and in embryonic stem cells and has role

118 4 plays an essential role in maintaining the inner cell mass and pluripotence of embryonic stem (ES)

119 ereas laminin 10/11 is expressed only in the inner cell mass and polar trophectoderm.

120 wth, differentiation, and maintenance of the inner cell mass and raise the possibility that this acti

121 ows hES cell line derivation from blastocyst inner cell mass and single blastomere cells without a ne

122 ctor Sox-2 is first expressed throughout the inner cell mass and subsequently becomes localized to th

123 t stem cells (TSCs) retain the identities of inner cell mass and TE, respectively, and, thus, are ide

124 LRH-1 is colocalized with Oct4 in the inner cell mass and the epiblast of embryos at early dev

125 elopment is the segregation of the embryonic inner cell mass and the extra-embryonic trophectoderm.

126 n to be essential for differentiation of the inner cell mass and the formation of the primitive endod

127 nto a blastocyst with two cell lineages (the inner cell mass and the trophectoderm), migrates within

128 sion involves segregation of the pluripotent inner cell mass and the trophectoderm, a process regulat

129 tion mouse embryo gives rise to cells of the inner cell mass and the trophectoderm.

130 nesis arise in the blastocyst, producing the inner cell mass and the trophectoderm.

131 man embryos form a blastocyst composed of an inner cell mass and trophectoderm (TE) cells, the latter

132 esults show primarily active ERK in both the inner cell mass and trophectoderm cells due to fibroblas

133 Here we show progressive segregation of inner cell mass and trophectoderm in early blastocysts,

134 ages and further developed a 3D model of the inner cell mass and trophectoderm in which individual ce

135 Blastocyst volume and cell number (both inner cell mass and trophectoderm) were also increased w

136 (-/-) blastocysts are viable, hatch, form an inner cell mass and trophectoderm, and implant (roughly

137 blastocysts were viable, hatched, formed an inner cell mass and trophectoderm, and implanted (E4.5),

138 elopment, including the determination of the inner cell mass and trophectoderm.

139 ) blastocysts showed defective growth of the inner cell mass and, in contrast to the approximately 65

140 conclude that cell fate decisions within the inner cell mass are dependent upon Oct4 and that Oct4 is

141 Cells of the inner cell mass are particularly dependent on Thoc1, as

142 fferentiation of ES cells and the blastocyst inner cell mass are poorly understood.

143 The inner cell mass arises from inner cells during subsequen

144 early-mid embryogenesis, particularly in the inner cell mass at E3.5, in epiblast at E6.5, and at lat

145 occurs between the pluripotent state of the inner cell mass at embryonic day 3.5 (E3.5) and the indu

146 round the time of implantation, cells of the inner cell mass cannot be maintained in vitro, and blast

147 source reduced blastocyst trophectoderm and inner cell mass cell number compared with that of embryo

148 blastocyst stage in vitro and a reduction in inner cell mass cell number in blastocysts.

149 giomotin-like 2, leads to differentiation of inner cell mass cells and compromised peri-implantation

150 g embryonic development, Cr1 is expressed in inner cell mass cells and the primitive streak, and late

151 g an enduring marker to trace the progeny of inner cell mass cells into the postimplantation visceral

152 ow the chromatin regulatory landscape in the inner cell mass cells is established from differentially

153 tem cells (hPSCs) have been derived from the inner cell mass cells of blastocysts (embryonic stem cel

154 inct models of pluripotency, preimplantation inner cell mass cells of human embryos and primed plurip

155 Sin3a is essential for the maintenance of inner cell mass cells of mouse blastocysts, embryonic fi

156 lastocyst transition disrupts the ability of inner cell mass cells to adopt lineage-specific identity

157 Mammalian inner cell mass cells undergo lineage-specific different

158 A is present in both the trophectodermal and inner cell mass cells.

159 helial characteristics by the non-epithelial inner cell mass cells.

160 y 7 and reduced numbers of trophectoderm and inner cell mass cells.

161 al uterus, the mouse blastocyst possesses an inner cell mass comprising two lineages: epiblast (Epi)

162 icating a trophectoderm defect, although the inner cell mass could grow in culture.

163 elop normally, but they subsequently exhibit inner cell mass death, diminished numbers of trophoblast

164 The primitive endoderm arises from the inner cell mass during mammalian pre-implantation develo

165 differentiation of pluripotent cells of the inner cell mass during the early stages of embryonic dev

166 d than those from wild-type blastocysts, the inner cell mass fails to expand, and the outgrowth degen

167 that resemble the cells seen in vivo in the inner cell mass has the potential to be an invaluable to

168 g labeled clones to the trophectoderm or the inner cell mass in a subset of embryos.

169 s showed greatly diminished expansion of the inner cell mass in culture, and this finding suggests th

170 s showed greatly diminished expansion of the inner cell mass in culture.

171 ment of the mouse embryo, descendants of the inner cell mass in the early epiblast transit from the n

172 lifespan of the transient pluripotent bovine inner cell mass in vitro.

173 the segregation of the trophectoderm and the inner cell mass influence lineage fate, via differential

174 Sox2, and Fgf4, but when placed in vitro the inner cell mass initially proliferates and then fails to

175 lastocyst complementation, in which only the inner cell mass is formed from a few injected ES cells,

176 imitive endoderm layer on the surface of the inner cell mass is one of the earliest epithelial morpho

177 anog, pluripotency does not develop, and the inner cell mass is trapped in a pre-pluripotent, indeter

178 anisms through which FGF signaling regulates inner cell mass lineage restriction and cell commitment

179 trophectoderm and a subset of embryos showed inner cell mass localization.

180 outgrowth studies indicate that neither the inner cell mass nor trophectoderm survives.

181 Both embryonic stem cells (derived from the inner cell mass of a blastocyst) and adult stem cells (f

182 bryonic stem cells (HESC) generated from the inner cell mass of a human preimplantation embryo.

183 l lines are conventionally isolated from the inner cell mass of blastocysts and, in a few instances,

184 Pluripotent cells develop within the inner cell mass of blastocysts, a mosaic of cells surrou

185 lso leads to defects in the expansion of the inner cell mass of blastocysts, a transient pluripotent

186 Nanog, a core pluripotency factor in the inner cell mass of blastocysts, is also expressed in uni

187 ation of the primitive endoderm covering the inner cell mass of early mouse embryos can be simulated

188 This status is consistent with the inner cell mass of human blastocysts, where MYC transcri

189 are pluripotent cell types derived from the inner cell mass of human blastocysts.

190 d for expansion of epiblast cells within the inner cell mass of mice in vivo.

191 pluripotent primitive ectoderm cells in the inner cell mass of mouse blastocysts.

192 hy does a totipotent state linger within the inner cell mass of mouse embryos?

193 ells co-exist and are convertible within the inner cell mass of murine blastocysts and embryonic stem

194 is significantly elevated in the presumptive inner cell mass of Oct4 null embryos, suggesting an unex

195 These cells derived from the inner cell mass of pig blastocysts are clearly distinct

196 naive type, pluripotent stem cells from the inner cell mass of porcine blastocysts by up-regulating

197 growth factor (FGF)-4 gene expression in the inner cell mass of the blastocyst and in EC cells requir

198 ence revealed that ZIP3 was expressed in the inner cell mass of the blastocyst and later during embry

199 specific developmental stages, including the inner cell mass of the blastocyst, the myotomes, and the

200 10% in primordial germ cells and 20% in the inner cell mass of the blastocyst.

201 cells are clonal cell lines derived from the inner cell mass of the developing blastocyst that can pr

202 an apparently random distribution within the inner cell mass of the early blastocyst and then segrega

203 ting oogenesis and partitioning cells to the inner cell mass of the early embryo.

204 At E4.0 the inner cell mass of the mouse blastocyst consists of a co

205 The inner cell mass of the mouse blastocyst gives rise to th

206 The inner cell mass of the mouse pre-implantation blastocyst

207 In support, the inner cell mass of Upf2-null blastocysts rapidly regress

208 ated human cells with ES properties from the inner cell mass or developing germ cells can provide a s

209 of ER was observed in cells derived from the inner cell mass or the trophoblast.

210 and of whether the blastomere is within the inner cell mass or the trophoectoderm.

211 2C-like ES cells and show that they lack the inner cell mass pluripotency proteins Oct4 (also known a

212 mbryos, with higher expression levels in the inner cell mass progenitor cells.

213 eover, mTOR(-/-) embryos display a lesion in inner cell mass proliferation, consistent with the inabi

214 velopmental pluripotency state compared with inner cell mass stage murine embryonic stem cells (mESCs

215 t after prolonged culture, the growth of the inner cell mass stopped, no visceral endoderm formed, an

216 ian embryo development is construction of an inner cell mass surrounded by a trophoectoderm (a shell

217 se (UPR) and cell signaling, is required for inner cell mass survival during early embryonic developm

218 specifies two cell lineages: the pluripotent inner cell mass that forms the fetus, and the outer trop

219 , around implantation, epiblast cells of the inner cell mass that give rise to the embryo reactivate

220 lastocysts had a severe growth defect of the inner cell mass that was accompanied by apoptosis.

221 onic from extra-embryonic tissues within the inner cell mass to generate the epiblast (EPI), which wi

222 did not progress much further even when the inner cell mass was 'rescued' from the abnormal placenta

223 Although the inner cell mass was unaffected, the trophectoderm of hom

224 racteristics of endoderm, trophectoderm, and inner cell mass were observed in the outgrowth of the ha

225 hatch, form the trophectoderm, or expand the inner cell mass when cultured in vitro.

226 derm layer, but could not be detected in the inner cell mass without prior fixation and permeabilizat

227 establishment of trophoblast and pluriblast (inner cell mass) lineages and for subsequent development

228 to the embryonic part (region containing the inner cell mass) that will give rise to the embryo prope

229 In the embryonic tissues of the inner cell mass, a random form of XCI occurs in blastocy

230 and exhibited a cell proliferation defect in inner cell mass, accompanied by a slight decrease in Oct

231 d cells in the trophectoderm compared to the inner cell mass, although we do detect such enrichment i

232 into basement membrane between endoderm and inner cell mass, and the ensuing differentiation of epib

233 Despite their origin from the inner cell mass, embryonic stem (ES) cells undergo diffe

234 onic development include polarization of the inner cell mass, followed by formation of an expanded lu

235 to the trophoblast of the placenta, and the inner cell mass, from which is derived the embryo proper

236 Reprogramming of genes expressed in the inner cell mass, from which ntESCs are derived, seems to

237 An important example is the mammalian inner cell mass, in which the primitive endoderm (PrE, f

238 emergence of three distinct populations: the inner cell mass, primitive endoderm and trophectoderm.

239 (ESC), which are derived from the blastocyst inner cell mass, retain properties of self-renewal and t

240 genes have minimal epigenetic memory in the inner cell mass, whereas others may require active erasu

241 thought to be functionally equivalent to the inner cell mass, which lacks the ability to produce all

242 l architecture of blastocysts, presenting an inner cell mass-like structure, with epiblast- and primi

243 C phenotypes with simultaneous activation of inner cell mass-specific gene expression.

244 to the center of the embryo to establish the inner cell mass-the early precursor of the fetus.

245 culture display abnormal expansion of their inner cell mass.

246 s but was undetectable in blastomeres of the inner cell mass.

247 iimplantational lethality and defects in the inner cell mass.

248 ells and governing the fate of the primitive inner cell mass.

249 expression became restricted to cells of the inner cell mass.

250 and cell death of both the trophectoderm and inner cell mass.

251 conceptus leads to the growth failure of the inner cell mass.

252 to Oct3/4 in mammals during formation of the inner cell mass.

253 for survival of the pluripotent cells of the inner cell mass.

254 vitro revealed impaired proliferation of the inner cell mass.

255 omosome inactivation is then reversed in the inner cell mass.

256 to two cell types, the trophectoderm and the inner cell mass.

257 ve, divide, and contribute to the developing inner cell mass.

258 ion of pluripotency and the formation of the inner cell mass.

259 of forming an epithelial layer covering, the inner cell mass.

260 rations, AMBMP caused disorganization of the inner cell mass.

261 expanded stage a 20% cellular deficit in the inner-cell mass without any change in trophectoderm cell

262 4 h show no sign of "catch-up" growth of the inner-cell mass, although under these conditions, the tr

263 pmt1(-/-) blastocysts failed to outgrow, and inner-cell-mass cells failed to thrive.

264 ll cells, the morphology appeared normal and inner cell masses (ICMs) formed, but resultant embryos h

265 Inner cell masses (ICMs) from Pdcd2(-/-) blastocysts fai

266 Concurrently, OCT4 null inner cell masses ectopically activate a subset of troph

267 Inner cell masses explanted from gp130(-/-) delayed blas

268 Comparison to inner cell masses of marmoset primate blastocysts identi

269 Inner cell masses were isolated by immunosurgery and pla

270 Sporulation involves an inner cell maturing into a spore and an outer cell nurtu

271 mbrane and the cell wall before reaching the inner cell membrane for subsequent viral DNA injection.

272 al toxins that spontaneously insert into the inner cell membrane of sensitive bacteria to form voltag

273 ent within the processes and adjacent to the inner cell membrane of the differentiated astrocytes.

274 the movement of the T4 endolysin though the inner cell membrane to its target, the cell wall.

275 not kill the host cells) associates with the inner cell membrane, suggesting a possible correlation b

276 s, and thus the kinase, are clustered on the inner cell membrane.

277 ttributed to the mitochondria as well as the inner cell membrane.

278 and find that both proteins localise at the inner cell membrane.

279 Second, cAMP promotes the death of inner cells occupying the lumen.

280 acellular matrix (ECM), and the apoptosis of inner cells of acini lacking contact with the ECM.

281 mitive endoderm differentiation, even in the inner cells of ES cell aggregates.

282 ve apical constriction to position the first inner cells of living mouse embryos.

283 polarization of outer cells and apoptosis of inner cells of the acinus.

284 However, in inner cells of the placode, both Crumbs and Rok are isot

285 ers likely contributed to reduction of Na in inner cells of the tips.

286 yo, but the continuous cell-cell contact of ;inner' cells of the morulae seemingly precludes formatio

287 y more of these organelles located along the inner cell periphery.

288 th rate, the termini usually remain near the inner cell pole and migrate to the cell centre in the mi

289 one arrestin from cone outer segments to the inner cell regions was disrupted in the absence of GC1,

290 cells differentiate into trophectoderm while inner cells retain pluripotency to become inner cell mas

291 The MUC1 CT was detected at the inner cell surface, in the cytosol, and in the nucleus o

292 on display increased ERK pulse frequency and inner cell survival.

293 solid cell mass by the apoptotic removal of inner cells that do not contact the basement membrane (B

294 en placenta or asymmetric that gives rise to inner cells that generate the embryo proper.

295 bles the tumor to minimize the distance from inner cells to external nutrients, contributing to cance

296 mally enlarged vacuoles and a poorly defined inner cell wall layer, which consequently results in dis

297 . albicans, most beta-1,3-glucan lies in the inner cell wall shielded, by the outer mannan layer, fro

298 0 residues were assigned to positions at the inner, cell-wall-facing lattice surface, while 5 residue

299 nforcement by mechanical feedback within the inner cell walls, not the outer epidermal wall, in guidi

300 o layered cortex with an outer plexiform and inner cell zone (Layers 1 and 2, respectively).