ライフサイエンスコーパス: inner cell mass

1 culture display abnormal expansion of their inner cell mass.

2 s but was undetectable in blastomeres of the inner cell mass.

3 iimplantational lethality and defects in the inner cell mass.

4 ells and governing the fate of the primitive inner cell mass.

5 expression became restricted to cells of the inner cell mass.

6 and cell death of both the trophectoderm and inner cell mass.

7 conceptus leads to the growth failure of the inner cell mass.

8 to Oct3/4 in mammals during formation of the inner cell mass.

9 omosome inactivation is then reversed in the inner cell mass.

10 for survival of the pluripotent cells of the inner cell mass.

11 vitro revealed impaired proliferation of the inner cell mass.

12 to two cell types, the trophectoderm and the inner cell mass.

13 ve, divide, and contribute to the developing inner cell mass.

14 ental lineages and lineages derived from the inner cell mass.

15 rmal lineages from lineages derived from the inner cell mass.

16 ion of pluripotency and the formation of the inner cell mass.

17 of forming an epithelial layer covering, the inner cell mass.

18 rations, AMBMP caused disorganization of the inner cell mass.

19 In the embryonic tissues of the inner cell mass, a random form of XCI occurs in blastocy

20 and exhibited a cell proliferation defect in inner cell mass, accompanied by a slight decrease in Oct

21 d cells in the trophectoderm compared to the inner cell mass, although we do detect such enrichment i

22 4 h show no sign of "catch-up" growth of the inner-cell mass, although under these conditions, the tr

23 of an epithelium enveloping the pluripotent inner cell mass and a fluid-filled lumen, the blastocyst

24 and capable of hatching and forming both an inner cell mass and a trophectoderm.

25 reas another transiently resembles the early inner cell mass and correspondingly gains greater develo

26 rsors for two cell lineages: the pluripotent inner cell mass and differentiating trophectoderm.

27 In mouse embryos, Gdf3 is expressed in the inner cell mass and epiblast, and null mutants frequentl

28 Oct4 expression becomes restricted to the inner cell mass and epiblast.

29 Initial cell lineages that presage the inner cell mass and extra-embryonic trophectoderm are es

30 oteins produced by the developing conceptus (inner cell mass and extraembryonic membranes).

31 therefore acts primarily in construction of inner cell mass and germ cell states rather than in the

32 Mouse Nanog is expressed in the inner cell mass and in embryonic stem cells and has role

33 4 plays an essential role in maintaining the inner cell mass and pluripotence of embryonic stem (ES)

34 ereas laminin 10/11 is expressed only in the inner cell mass and polar trophectoderm.

35 wth, differentiation, and maintenance of the inner cell mass and raise the possibility that this acti

36 ows hES cell line derivation from blastocyst inner cell mass and single blastomere cells without a ne

37 ctor Sox-2 is first expressed throughout the inner cell mass and subsequently becomes localized to th

38 t stem cells (TSCs) retain the identities of inner cell mass and TE, respectively, and, thus, are ide

39 LRH-1 is colocalized with Oct4 in the inner cell mass and the epiblast of embryos at early dev

40 elopment is the segregation of the embryonic inner cell mass and the extra-embryonic trophectoderm.

41 n to be essential for differentiation of the inner cell mass and the formation of the primitive endod

42 nto a blastocyst with two cell lineages (the inner cell mass and the trophectoderm), migrates within

43 sion involves segregation of the pluripotent inner cell mass and the trophectoderm, a process regulat

44 nesis arise in the blastocyst, producing the inner cell mass and the trophectoderm.

45 tion mouse embryo gives rise to cells of the inner cell mass and the trophectoderm.

46 man embryos form a blastocyst composed of an inner cell mass and trophectoderm (TE) cells, the latter

47 esults show primarily active ERK in both the inner cell mass and trophectoderm cells due to fibroblas

48 Here we show progressive segregation of inner cell mass and trophectoderm in early blastocysts,

49 ages and further developed a 3D model of the inner cell mass and trophectoderm in which individual ce

50 Blastocyst volume and cell number (both inner cell mass and trophectoderm) were also increased w

51 (-/-) blastocysts are viable, hatch, form an inner cell mass and trophectoderm, and implant (roughly

52 blastocysts were viable, hatched, formed an inner cell mass and trophectoderm, and implanted (E4.5),

53 elopment, including the determination of the inner cell mass and trophectoderm.

54 ) blastocysts showed defective growth of the inner cell mass and, in contrast to the approximately 65

55 ised marker, specific initially to the early inner cell mass, and subsequently identifying presumptiv

56 into basement membrane between endoderm and inner cell mass, and the ensuing differentiation of epib

57 conclude that cell fate decisions within the inner cell mass are dependent upon Oct4 and that Oct4 is

58 Cells of the inner cell mass are particularly dependent on Thoc1, as

59 fferentiation of ES cells and the blastocyst inner cell mass are poorly understood.

60 Trophectoderm (TE) and the inner cell mass are the first two lineages in murine emb

61 The inner cell mass arises from inner cells during subsequen

62 early-mid embryogenesis, particularly in the inner cell mass at E3.5, in epiblast at E6.5, and at lat

63 occurs between the pluripotent state of the inner cell mass at embryonic day 3.5 (E3.5) and the indu

64 rescence on control and OCT4 null blastocyst inner cell masses at two developmental stages.

65 round the time of implantation, cells of the inner cell mass cannot be maintained in vitro, and blast

66 source reduced blastocyst trophectoderm and inner cell mass cell number compared with that of embryo

67 blastocyst stage in vitro and a reduction in inner cell mass cell number in blastocysts.

68 giomotin-like 2, leads to differentiation of inner cell mass cells and compromised peri-implantation

69 g embryonic development, Cr1 is expressed in inner cell mass cells and the primitive streak, and late

70 g an enduring marker to trace the progeny of inner cell mass cells into the postimplantation visceral

71 ow the chromatin regulatory landscape in the inner cell mass cells is established from differentially

72 tem cells (hPSCs) have been derived from the inner cell mass cells of blastocysts (embryonic stem cel

73 inct models of pluripotency, preimplantation inner cell mass cells of human embryos and primed plurip

74 Sin3a is essential for the maintenance of inner cell mass cells of mouse blastocysts, embryonic fi

75 lastocyst transition disrupts the ability of inner cell mass cells to adopt lineage-specific identity

76 Mammalian inner cell mass cells undergo lineage-specific different

77 e in the transcription factor GATA6 in other inner cell mass cells, setting them on the course toward

78 A is present in both the trophectodermal and inner cell mass cells.

79 helial characteristics by the non-epithelial inner cell mass cells.

80 y 7 and reduced numbers of trophectoderm and inner cell mass cells.

81 pmt1(-/-) blastocysts failed to outgrow, and inner-cell-mass cells failed to thrive.

82 stantially more misallocated cells and fewer inner-cell-mass cells.

83 al uterus, the mouse blastocyst possesses an inner cell mass comprising two lineages: epiblast (Epi)

84 icating a trophectoderm defect, although the inner cell mass could grow in culture.

85 elop normally, but they subsequently exhibit inner cell mass death, diminished numbers of trophoblast

86 The primitive endoderm arises from the inner cell mass during mammalian pre-implantation develo

87 differentiation of pluripotent cells of the inner cell mass during the early stages of embryonic dev

88 Concurrently, OCT4 null inner cell masses ectopically activate a subset of troph

89 Despite their origin from the inner cell mass, embryonic stem (ES) cells undergo diffe

90 Inner cell masses explanted from gp130(-/-) delayed blas

91 d than those from wild-type blastocysts, the inner cell mass fails to expand, and the outgrowth degen

92 ioned, consistent with placental rather than inner cell mass fate.

93 onic development include polarization of the inner cell mass, followed by formation of an expanded lu

94 3 signaling is also required to maintain the inner cell mass (from which stem cells are derived).

95 to the trophoblast of the placenta, and the inner cell mass, from which is derived the embryo proper

96 Reprogramming of genes expressed in the inner cell mass, from which ntESCs are derived, seems to

97 ate into trophectoderm (future placenta) and inner cell mass (future fetus).

98 that resemble the cells seen in vivo in the inner cell mass has the potential to be an invaluable to

99 ring mammalian preimplantation, cells of the inner cell mass (ICM) adopt either an embryonic or an ex

100 f geminin in the mouse prevents formation of inner cell mass (ICM) and causes premature endoreduplica

101 distinct pluripotent states representing the inner cell mass (ICM) and epiblast embryos.

102 is expressed in the pluripotent cells of the inner cell mass (ICM) and epiblast of the peri-implantat

103 horter telomeres apparent in the pluripotent Inner Cell Mass (ICM) and persisting after organogenesis

104 cell blastomeres that will contribute to the inner cell mass (ICM) and polar trophectoderm and undert

105 cells are pluripotent cells derived from the inner cell mass (ICM) and the epiblast, and have been su

106 omeres that will generate both the embryonic inner cell mass (ICM) and the supportive trophectoderm (

107 o that consists of two major components: the inner cell mass (ICM) and the trophectoderm (TE).

108 Communication between the inner cell mass (ICM) and the trophoblast layer of the b

109 Expanded blastocysts with existent inner cell mass (ICM) and trophectoderm (TE) cells under

110 ent, genesis of the first two cell lineages, inner cell mass (ICM) and trophectoderm (TE), is depende

111 ormation of the blastocyst consisting of the inner cell mass (ICM) and trophectoderm (TE).

112 loping into blastocysts with an identifiable inner cell mass (ICM) and trophectoderm (TE).

113 irections of differential expression between inner cell mass (ICM) and trophectoderm (TE).

114 the spatial organization and segregation of inner cell mass (ICM) and trophectoderm epithelium (TE)

115 IP in mouse embryonic stem (ES) cells and in inner cell mass (ICM) and trophectoderm of cultured blas

116 er positions of the embryo, establishing the inner cell mass (ICM) and trophectoderm.

117 lantation development, the generation of the inner cell mass (ICM) and trophoblast lineages comprises

118 Pluripotent cells in the inner cell mass (ICM) are the descendants of totipotent

119 g early murine embryogenesis, cells from the inner cell mass (ICM) can be specified in epiblast (Epi)

120 This analysis revealed that inner cell mass (ICM) cells have unrestricted developmen

121 k-sac-fated hypoblast cells from uncommitted inner cell mass (ICM) cells prior to implantation.

122 ells are generally derived by the culture of inner cell mass (ICM) cells, they are often assumed to b

123 ripotent human ES cells to those of isolated inner cell mass (ICM) cells.

124 expression is restricted to the pluripotent inner cell mass (ICM) cells.

125 The size of the inner cell mass (ICM) compartment is not reduced, howeve

126 ells toward either the trophectoderm (TE) or inner cell mass (ICM) compartments in pre-implantation e

127 In the mouse blastocyst, some cells of the inner cell mass (ICM) develop into primitive endoderm (P

128 ould enhance early embryogenesis and promote inner cell mass (ICM) formation via PI3K/AKT pathway act

129 f the mouse embryo distinguishes pluripotent inner cell mass (ICM) from differentiating trophectoderm

130 ls are trophectoderm (TE) precursors and the inner cell mass (ICM) gives rise to the embryo.

131 t-fertilization (dpf), and restricted to the inner cell mass (ICM) in 128-256 cell blastocysts (6dpf)

132 gregation of the trophectoderm (TE) from the inner cell mass (ICM) in the mouse blastocyst is determi

133 the epiblast and primitive endoderm from the inner cell mass (ICM) is a paradigm for cell fate specif

134 mation of trophectoderm (TE) and pluripotent inner cell mass (ICM) is one of the earliest events duri

135 traploid ESCs were able to contribute to the inner cell mass (ICM) just as diploid ESCs tagged with G

136 formation of the trophectoderm (TE) and the inner cell mass (ICM) lineages during preimplantation de

137 Specification of the trophectoderm (TE) and inner cell mass (ICM) lineages in the mouse blastocyst c

138 Genesis of the trophectoderm and inner cell mass (ICM) lineages occurs in two stages.

139 ed that Csn8 is predominantly present in the inner cell mass (ICM) of E3.5 blastocyst and is widely e

140 r is activated in both the trophectoderm and inner cell mass (ICM) of embryos at embryonic day 3.5 vi

141 ine is distinct from both human PSCs and the inner cell mass (ICM) of human blastocysts.

142 Here we show that the inner cell mass (ICM) of Mbd3-deficient blastocysts fail

143 The inner cell mass (ICM) of mouse blastocysts co-expresses

144 However, the inner cell mass (ICM) of mouse preimplantation blastocys

145 A subset of cells within the inner cell mass (ICM) of the blastocyst does not respond

146 le inner cells retain pluripotency to become inner cell mass (ICM) of the blastocyst.

147 ent epiblast precursors are specified in the inner cell mass (ICM) of the early blastocyst in a 'salt

148 The inner cell mass (ICM) of the implanting mammalian blasto

149 Since ESCs are derived from the inner cell mass (ICM) of the mammalian blastocyst, ESCs

150 Cells of the inner cell mass (ICM) of the mouse blastocyst differenti

151 primitive endoderm (PrE) lineages within the inner cell mass (ICM) of the mouse blastocyst involves i

152 (EPI), the two lineages specified within the inner cell mass (ICM) of the mouse blastocyst stage embr

153 versus pluripotent epiblast (EPI) within the inner cell mass (ICM) of the mouse blastocyst.

154 vel analysis of lineage specification in the inner cell mass (ICM) of the mouse blastocyst.

155 DNA methylation is first established in the inner cell mass (ICM) of the mouse blastocyst.

156 embryonic stem (ES) cells that resembles the inner cell mass (ICM) of the pre-implantation embryo.

157 embryonic) endoderm (PrE), arise from common inner cell mass (ICM) progenitors in mammalian embryos.

158 lose contact of polar trophectoderm with the inner cell mass (ICM) promotes proliferation of undiffer

159 ) of multicellular trophectoderm (TE) and/or inner cell mass (ICM) samples.

160 uous process starting with the generation of inner cell mass (ICM) that then differentiates into epib

161 ES cells are derived from mammalian inner cell mass (ICM) tissue that express the Class V PO

162 cell-fate decision, the specification of the inner cell mass (ICM) to primitive endoderm (PE) and epi

163 Within the inner cell mass (ICM), all cells relayed FGF/ERK signals

164 formation of the trophectoderm (TE) and the inner cell mass (ICM), and for repressing primitive endo

165 ial locations in a tight time window to form inner cell mass (ICM), and later epiblast (Epi) and prim

166 X-chromosome inactivation (XCI) in the mouse inner cell mass (ICM), and reactivation of X-linked gene

167 ality is due to a defect in expansion of the inner cell mass (ICM), as Mtb(-/-) blastocysts failed to

168 comprising trophectoderm (TE) surrounding an inner cell mass (ICM), confined to the polar region by t

169 ifferentiate to either trophectoderm (TE) or inner cell mass (ICM), followed by epiblast (EPI) or pri

170 contributes exclusively to the placenta, and inner cell mass (ICM), from which the embryo develops.

171 Perhaps most importantly, the inner cell mass (ICM), from which the foetus is derived

172 me trophectoderm, while inner cells form the inner cell mass (ICM), later differentiating into primit

173 In E3.5 inner cell mass (ICM), SOX2 regulates the ICM-trophectod

174 cells of the embryo proper, derived from the inner cell mass (ICM), undergo only random X inactivatio

175 egregation in the mouse embryo generates the inner cell mass (ICM), which gives rise to the pluripote

176 Here we show that inner cell mass (ICM)-generated cells expressing Blimp1,

177 be reverted to stable human preimplantation inner cell mass (ICM)-like naive states with only WNT, M

178 otransposons-derived regulatory elements for inner cell mass (ICM)-specific genes.

179 ablishment of the trophectoderm (TE) and the inner cell mass (ICM).

180 yonic stem (ES) cell lines, derived from the inner cell mass (ICM).

181 - blastocyst outgrowths revealed loss of the inner cell mass (ICM).

182 phectoderm (TE) and its segregation from the inner cell mass (ICM).

183 f primed PSCs and shares features with human inner cell mass (ICM).

184 ultifocal trophectoderm (TE) samples and the inner cell mass (ICM).

185 polarized trophectoderm cells from an apolar inner cell mass (ICM).

186 iptional program and segregating TE from the inner cell mass (ICM).

187 antly reduced cell numbers, first within the inner cell mass (ICM; early blastocyst), and later withi

188 P), trophectoderm (TE), blastocoel (BC), and inner cell-mass (ICM), using subjective and observer-dep

189 approach (four trophectoderms [TEs] and one inner cell mass [ICM] analyzed per blastocyst; n = 390),

190 ll cells, the morphology appeared normal and inner cell masses (ICMs) formed, but resultant embryos h

191 Inner cell masses (ICMs) from Pdcd2(-/-) blastocysts fai

192 Inner cell mass icO(2) was lower than trophectoderm, per

193 g labeled clones to the trophectoderm or the inner cell mass in a subset of embryos.

194 s showed greatly diminished expansion of the inner cell mass in culture, and this finding suggests th

195 s showed greatly diminished expansion of the inner cell mass in culture.

196 l extraembryonic tissue set aside within the inner cell mass in the blastocyst.

197 ment of the mouse embryo, descendants of the inner cell mass in the early epiblast transit from the n

198 lifespan of the transient pluripotent bovine inner cell mass in vitro.

199 An important example is the mammalian inner cell mass, in which the primitive endoderm (PrE, f

200 the segregation of the trophectoderm and the inner cell mass influence lineage fate, via differential

201 Sox2, and Fgf4, but when placed in vitro the inner cell mass initially proliferates and then fails to

202 lastocyst complementation, in which only the inner cell mass is formed from a few injected ES cells,

203 imitive endoderm layer on the surface of the inner cell mass is one of the earliest epithelial morpho

204 anog, pluripotency does not develop, and the inner cell mass is trapped in a pre-pluripotent, indeter

205 l architecture of blastocysts, presenting an inner cell mass-like structure, with epiblast- and primi

206 anisms through which FGF signaling regulates inner cell mass lineage restriction and cell commitment

207 establishment of trophoblast and pluriblast (inner cell mass) lineages and for subsequent development

208 trophectoderm and a subset of embryos showed inner cell mass localization.

209 outgrowth studies indicate that neither the inner cell mass nor trophectoderm survives.

210 Both embryonic stem cells (derived from the inner cell mass of a blastocyst) and adult stem cells (f

211 bryonic stem cells (HESC) generated from the inner cell mass of a human preimplantation embryo.

212 l lines are conventionally isolated from the inner cell mass of blastocysts and, in a few instances,

213 Pluripotent cells develop within the inner cell mass of blastocysts, a mosaic of cells surrou

214 lso leads to defects in the expansion of the inner cell mass of blastocysts, a transient pluripotent

215 Nanog, a core pluripotency factor in the inner cell mass of blastocysts, is also expressed in uni

216 ation of the primitive endoderm covering the inner cell mass of early mouse embryos can be simulated

217 This status is consistent with the inner cell mass of human blastocysts, where MYC transcri

218 are pluripotent cell types derived from the inner cell mass of human blastocysts.

219 d for expansion of epiblast cells within the inner cell mass of mice in vivo.

220 pluripotent primitive ectoderm cells in the inner cell mass of mouse blastocysts.

221 hy does a totipotent state linger within the inner cell mass of mouse embryos?

222 ells co-exist and are convertible within the inner cell mass of murine blastocysts and embryonic stem

223 is significantly elevated in the presumptive inner cell mass of Oct4 null embryos, suggesting an unex

224 These cells derived from the inner cell mass of pig blastocysts are clearly distinct

225 naive type, pluripotent stem cells from the inner cell mass of porcine blastocysts by up-regulating

226 growth factor (FGF)-4 gene expression in the inner cell mass of the blastocyst and in EC cells requir

227 ence revealed that ZIP3 was expressed in the inner cell mass of the blastocyst and later during embry

228 specific developmental stages, including the inner cell mass of the blastocyst, the myotomes, and the

229 10% in primordial germ cells and 20% in the inner cell mass of the blastocyst.

230 cells are clonal cell lines derived from the inner cell mass of the developing blastocyst that can pr

231 Telomerase is transiently activated in the inner cell mass of the developing blastocyst to reset te

232 an apparently random distribution within the inner cell mass of the early blastocyst and then segrega

233 ting oogenesis and partitioning cells to the inner cell mass of the early embryo.

234 At E4.0 the inner cell mass of the mouse blastocyst consists of a co

235 The inner cell mass of the mouse blastocyst gives rise to th

236 The inner cell mass of the mouse pre-implantation blastocyst

237 In support, the inner cell mass of Upf2-null blastocysts rapidly regress

238 Comparison to inner cell masses of marmoset primate blastocysts identi

239 ated human cells with ES properties from the inner cell mass or developing germ cells can provide a s

240 of ER was observed in cells derived from the inner cell mass or the trophoblast.

241 and of whether the blastomere is within the inner cell mass or the trophoectoderm.

242 ion, where morula cells become specified for inner cell mass or trophectoderm, includes cells previou

243 2C-like ES cells and show that they lack the inner cell mass pluripotency proteins Oct4 (also known a

244 last, or production of both tissues from the inner cell mass precursor.

245 emergence of three distinct populations: the inner cell mass, primitive endoderm and trophectoderm.

246 mbryos, with higher expression levels in the inner cell mass progenitor cells.

247 eover, mTOR(-/-) embryos display a lesion in inner cell mass proliferation, consistent with the inabi

248 (ESC), which are derived from the blastocyst inner cell mass, retain properties of self-renewal and t

249 C phenotypes with simultaneous activation of inner cell mass-specific gene expression.

250 velopmental pluripotency state compared with inner cell mass stage murine embryonic stem cells (mESCs

251 t after prolonged culture, the growth of the inner cell mass stopped, no visceral endoderm formed, an

252 ian embryo development is construction of an inner cell mass surrounded by a trophoectoderm (a shell

253 se (UPR) and cell signaling, is required for inner cell mass survival during early embryonic developm

254 specifies two cell lineages: the pluripotent inner cell mass that forms the fetus, and the outer trop

255 , around implantation, epiblast cells of the inner cell mass that give rise to the embryo reactivate

256 lastocysts had a severe growth defect of the inner cell mass that was accompanied by apoptosis.

257 to the embryonic part (region containing the inner cell mass) that will give rise to the embryo prope

258 ally differentiate into trophectoderm and an inner cell mass, the latter of which differentiates into

259 to the center of the embryo to establish the inner cell mass-the early precursor of the fetus.

260 onic from extra-embryonic tissues within the inner cell mass to generate the epiblast (EPI), which wi

261 We reveal that human trophectoderm/inner cell mass transcriptomes diverge at the transition

262 this is linked to the dynamics of the prior inner cell mass/trophectoderm fate decision through the

263 did not progress much further even when the inner cell mass was 'rescued' from the abnormal placenta

264 Although the inner cell mass was unaffected, the trophectoderm of hom

265 racteristics of endoderm, trophectoderm, and inner cell mass were observed in the outgrowth of the ha

266 Inner cell masses were isolated by immunosurgery and pla

267 hatch, form the trophectoderm, or expand the inner cell mass when cultured in vitro.

268 genes have minimal epigenetic memory in the inner cell mass, whereas others may require active erasu

269 thought to be functionally equivalent to the inner cell mass, which lacks the ability to produce all

270 derm layer, but could not be detected in the inner cell mass without prior fixation and permeabilizat

271 expanded stage a 20% cellular deficit in the inner-cell mass without any change in trophectoderm cell