ライフサイエンスコーパス: inner ear

1 o ascribe resulting phenotypes solely to the inner ear.

2 the lagena [1], a sensory epithelium of the inner ear.

3 exact location of cellular damage inside the inner ear.

4 rentially expressed within hair cells of the inner ear.

5 to analyze the effects of noise on the mouse inner ear.

6 le in endothelial cell migration towards the inner ear.

7 ial patterns of sensory specification in the inner ear.

8 osensitivity in the tmc1/2a/2b triple mutant inner ear.

9 h enlarged endolymphatic compartments of the inner ear.

10 ene deletion/reporter gene activation in the inner ear.

11 (SGNs) are specialzed bipolar neurons in the inner ear.

12 -cell-autonomous protective signaling in the inner ear.

13 ot strictly limited to hair cells within the inner ear.

14 by hair cells, the sensory receptors of the inner ear.

15 nd saccule, the main hearing endorgan of the inner ear.

16 he otic vesicle, the embryonic anlage of the inner ear.

17 nd research on therapies for diseases of the inner ear.

18 rce of cells for cell-based therapies of the inner ear.

19 rgy to enhance mechanical oscillation in the inner ear.

20 al for overall development of HCs within the inner ear.

21 ransducer (MET) channel in hair cells of the inner ear.

22 endolymph in the membranous labyrinth in the inner ear.

23 ghts that mediate mechanotransduction in the inner ear.

24 with limited cell type diversification, the inner ear.

25 is the mechano-transduction apparatus of the inner ear.

26 (N48K) mutation in sensory hair cells of the inner ear.

27 imination of XIRP2 protein expression in the inner ear.

28 ium secretion by the stria vascularis in the inner ear.

29 terize hair-cell mechano-transduction in the inner ear.

30 we microinjected ASO directly into the E12.5 inner ear.

31 to deformities of the limbs, neural tube and inner ear.

32 , which are expressed in both the kidney and inner ear.

33 nery in highly specialized hair cells of the inner ear.

34 opmental malformations of the middle ear and inner ear.

35 on-sensory formation of the vestibule of the inner ear.

36 ng may play multiple roles in the developing inner ear.

37 tic AAVs (AAV2.7m8 and AAV8BP2) in the mouse inner ear.

38 fish to study size control of the developing inner ear.

39 sta4, and the levels of GSTA4 protein in the inner ears.

40 f the different structures of the middle and inner ear (0 = not visualized, 3 = perfectly identified

41 uction within the semicircular canals of the inner ear [4].

42 her syndrome corrects gene expression in the inner ear, a therapeutically relevant target tissue.

43 ructure located in the ventral region of the inner ear, acts as the primary structure for the percept

44 e results suggest that a gradient of Fzd3 in inner ear afferents directs projections to the correct d

45 central dopaminergic neurons project to the inner ear and could modulate acoustic signals at the ear

46 on of hair cells and supporting cells in the inner ear and is a widely used sensory marker.

47 (ES) is a cystic organ that is a part of the inner ear and is connected to the cochlea and vestibule.

48 in outer hair cells (OHCs) of the mammalian inner ear and is required for cochlear amplification, a

49 r cell regeneration in vivo in the zebrafish inner ear and lateral line.

50 ell proliferation of supporting cells in the inner ear and lateral line.

51 fferent versus efferent circuits between the inner ear and the brain.

52 characteristics of DA fibers innervating the inner ear and the hindbrain auditory efferent nucleus in

53 mation of the distinct sensory organs of the inner ear and the non-sensory domains that separate them

54 cells (RGC), spiral and vestibular ganglia, inner ear and vestibular hair cell neurons in the vestib

55 any genes are misregulated in the diminuendo inner ear and we report here further misregulated genes.

56 novel role for Rsph9 in the kinocilia of the inner ear and/or lateral line neuromasts.

57 hanosensory hair cells (HCs) residing in the inner ear are critical for hearing and balance.

58 The semicircular canals of the mammalian inner ear are derived from epithelial pouches in which e

59 Hair cells of the inner ear are essential for hearing and balance.

60 Sensory hair cells of the inner ear are exposed to continuous mechanical stress, c

61 use the fragile membranous structures in the inner ear are hard to visualize undistorted and in full.

62 e mechanoreceptive sensory hair cells in the inner ear are selectively vulnerable to numerous genetic

63 de their hearing sensitivity range and their inner ears are partly undeveloped, which accounts for th

64 r cells, the mechanosensory receptors of the inner ear, are responsible for hearing and balance.

65 nlargement of the endolymphatic space in the inner ear areas; moreover, it rescued hearing and vestib

66 or the processing of auditory signals in the inner ear, as BACE1-deficient mice exhibit significant h

67 In the inner ear, at least two systems regulate the planar pola

68 the sites of damage through the detection of inner ear blood-circulating biomarkers.

69 ve differences between sensory organs of the inner ear, but shows that additional factors to Atoh1 ma

70 also mapped regions of open chromatin in the inner ear by ATAC-seq that, in combination with Gli2 ChI

71 vaccination, the patches were applied to the inner ear by hand without an applicator.

72 construction of a complex sensory organ, the inner ear, by imaging zebrafish embryos in vivo over an

73 a HMGIC fusion partner-like 5, transmembrane inner ear, calcium and integrin-binding family member 2,

74 Structures in the inner ear can help determine the evolutionary relationsh

75 Because the human inner ear cannot be visualized during life, histopatholo

76 es renewed proliferation and regeneration of inner ear cell types.

77 hearing loss occur at the cellular level and inner ear cells are very sensitive to autolysis.

78 Here in vivo clonal analysis of mouse inner ear cells during development demonstrates clonal r

79 ut does possess the highly derived brain and inner ear characteristic of the latest Cretaceous specie

80 Mechano-sensory hair cells within the inner ear cochlea are essential for the detection of sou

81 Throughout postnatal maturation of the mouse inner ear, cochlear hair cells display at least two type

82 How does the inner ear communicate with the cerebellar cortex to main

83 elaborate, as they have outer-, middle-, and inner-ear components.

84 These new findings are inconsistent with the inner-ear compression mechanism that some have used to e

85 The aims of this study were to manipulate inner ear connexin expression in vivo using BAAV vectors

86 The inner ear consists of two otocyst-derived, structurally

87 Histopathologic study of the human inner ear continues to emphasize the need for non- or mi

88 3D views of external and internal (endocast, inner ear) cranial structures.

89 e for most of the syndromic defects, exhibit inner ear defects and hyperactivity.

90 the mechanisms underlying inherited forms of inner ear deficits has considerably improved during the

91 ions of an extracellular tissue found in the inner ear demonstrating a mechanism of frequency separat

92 howed that metabolic effects of noise on the inner ear depend on the intensity and duration of exposu

93 nerves.SIGNIFICANCE STATEMENT The vertebrate inner ear detects and transmits auditory information ove

94 The vestibular system of the inner ear detects head position using three orthogonally

95 h could be used to investigate mechanisms of inner ear development and disease as well as regenerativ

96 entify new gene interactions responsible for inner ear development and for the segregation of the oti

97 MEKK4) expression is highly regulated during inner ear development and is critical to normal cytoarch

98 system should facilitate the study of human inner ear development and research on therapies for dise

99 ary functions in different cell types during inner ear development and that its continued expression

100 finger transcription factor gata3 regulates inner ear development from the formation of the embryoni

101 FGF8 signaling plays diverse roles in inner ear development, acting at multiple stages from ot

102 plex interplay between alternative splicing, inner ear development, and auditory function.

103 During inner ear development, primary auditory neurons named sp

104 To evaluate these options during inner ear development, we used in situ hybridization or

105 restricted and temporally dynamic throughout inner ear development.

106 ment strategies for genetic hearing loss and inner ear development.

107 nct progenitor populations from the neonatal inner ear differentiate to cell types associated with th

108 step in developing miRNAs as biomarkers for inner ear disease is linking patterns of miRNA expressio

109 approach to diagnosing patients with active inner ear disease.

110 lopment of reliable biomarkers for different inner ear diseases.

111 ts with episodic vertigo due to a peripheral inner-ear disorder.

112 Fifty percent of inner ear disorders are caused by genetic mutations.

113 A key to improving the diagnosis of inner ear disorders is the development of reliable bioma

114 ntial of ALD for the prevention/treatment of inner ear disorders such as age-related hearing loss.

115 To develop treatments for genetic inner ear disorders, we designed gene replacement therap

116 table for translation to humans with genetic inner ear disorders.

117 Par3 deletion in the inner ear disrupted cochlear outgrowth, hair bundle orie

118 h as the otic placode that gives rise to the inner ear do not exist.

119 However, other functions for inner ear dopamine have not been investigated, and the e

120 findings highlight a biological link between inner ear dysfunction and behavioral disorders and how s

121 pproaches in mice, the authors show that (1) inner ear dysfunction due to either Tbx1 or Slc12a2 muta

122 Furthermore, we show that (1) inner ear dysfunction due to the tissue-specific loss of

123 rmal growth rates in mouse models of genetic inner ear dysfunction.

124 ther hyperactivity or anxiety co-occurs with inner ear dysfunction.

125 hether hyperactivity or anxiety coexist with inner ear dysfunction.

126 d during optokinetic reflex compensation for inner ear dysfunction.

127 In the inner ear, EF-hand calcium buffers may play a significan

128 Vestibular hair cells in the inner ear encode head movements and mediate the sense of

129 n combination with Gli2 ChIP-seq, identified inner ear enhancers in the vicinity of Shh-responsive ge

130 out the otic placode lineage, comprising the inner ear epithelium and neurons.

131 howed that both genes are expressed in mouse inner ear, especially in hair cells, further suggesting

132 Maintenance of the composition of inner ear fluid and regulation of electrolytes and acid-

133 xperimental-modeling study suggests that (1) inner-ear fluid inertia is an important mechanism for BC

134 eloped a computational BC model based on the inner-ear fluid-inertia mechanism, and the simulated eff

135 ics based on the morphology, dynamics of the inner ear fluids, and membranous labyrinth deformability

136 2, and PlxnA1 in the chicken (Gallus gallus) inner ear from embryonic day (E)5-E10.

137 Inner ears from two mass strandings of long-finned pilot

138 adequately activate genes crucial for normal inner ear function and acid-base regulation in the kidne

139 The data represent unprecedented recovery of inner ear function and suggest that biological therapies

140 ride cotransporter and is also necessary for inner ear function, causes hyperactivity; (2) vestibular

141 ck is important for long-term maintenance of inner ear function.

142 gene replacement as a strategy for restoring inner ear functions in a mouse model of Usher syndrome t

143 at during postnatal development in the mouse inner ear gata3 is required for the biophysical maturati

144 s, techniques and viral vectors employed for inner ear gene therapy and the advancements in this fiel

145 The use of viral vectors for inner ear gene therapy is receiving increased attention

146 at AAV2.7m8 is an excellent viral vector for inner ear gene therapy targeting cochlear hair cells and

147 y paving the way for treatment with emerging inner ear gene therapy.

148 reatly expand the potential applications for inner ear gene therapy.

149 Damage to inner ear generally leads to permanent hearing loss in h

150 nnections establish sensory maps between the inner ear hair cells and the vestibular and auditory nuc

151 annels at the tips of sensory stereocilia of inner ear hair cells are gated by the tension of 'tip li

152 ates its effects in vivo, we discovered that inner ear hair cells are much more vulnerable to loss of

153 Inner ear hair cells are particularly vulnerable to oxid

154 miting the growth of transducing stereocilia.Inner ear hair cells detect sound through deflection of

155 Inner ear hair cells detect sound through deflection of

156 ilage defects in Xenopus and misalignment of inner ear hair cells in mouse.

157 Regeneration of mature mammalian inner ear hair cells remains to be a challenge.

158 The bundle of stereocilia on inner ear hair cells responds to subnanometer deflection

159 stereociliary bundle, the sensory antenna of inner ear hair cells, and in the mechanoelectrical trans

160 wn cells of the embryonic node, kinocilia of inner ear hair cells, and several cell lines.

161 The transduction compartment of inner ear hair cells, the hair bundle, is composed of st

162 the driving force for sound transduction by inner ear hair cells.

163 this protein between the frog and the mouse inner ear hair cells.

164 mechanoelectrical transduction (MET) in the inner-ear hair cells of larval zebrafish.

165 The hair bundle--the sensory organelle of inner-ear hair cells of vertebrates--exemplifies the abi

166 t of mechanosensory transduction channels in inner-ear hair cells(6).

167 Tip link filaments convey force and gate inner-ear hair-cell transduction channels to mediate per

168 The human inner ear has an intricate spiral shape often compared t

169 oaches to introduce viral particles into the inner ear have been described, presumed physiological ba

170 and balance organs of the neonatal mammalian inner ear have the capacity to generate new hair cells a

171 a model to study HC development and to drive inner ear HC regeneration.

172 ical stimulation of vestibular organs in the inner ear helps to dissociate vestibular impairments tha

173 ear (TME) that transmits sound waves to the inner ear; however, numerous species lack some or all TM

174 The mammalian inner ear (IE) subserves auditory and vestibular sensati

175 specialized sensory hair cells (HCs) in the inner ear (IE) to convey information about sound, accele

176 specialized sensory hair cells (HCs) in the inner ear (IE) to convey information about sound, accele

177 , we present that reprogramming of the adult inner ear induces renewed proliferation and regeneration

178 The system faithfully recapitulates mouse inner ear induction followed by self-guided development

179 Mechanoelectrical transduction in the inner ear is a biophysical process underlying the senses

180 The inner ear is a complex vertebrate sense organ, yet it ar

181 Since the inner ear is an important but sensitive organ of hearing

182 ed by the death of sensory hair cells of the inner ear is an unfortunate side effect for many patient

183 Each vestibular sensory epithelium in the inner ear is divided morphologically and physiologically

184 ochlea, part of the osseous labyrinth of the inner ear, is now one of the most frequently used skelet

185 pattern the sensorineural components of the inner ear, its role in middle ear development has been l

186 how pitch information is extracted from the inner ear itself.

187 The adult mammalian inner ear lacks the capacity to divide or regenerate.

188 t time and that lack of HGF signaling in the inner ear leads to profound hearing loss in the mouse.

189 development of the sensory hair cells in the inner ear led to therapeutic efforts to restore these ce

190 In the inner ear, levels of HGF must be fine-tuned for normal h

191 ane of the lateral semicircular canal of the inner ear lies parallel to the horizon when the head is

192 ar magnetite crystals, suggesting that if an inner ear magnetic sensor does exist it relies on a diff

193 ects with valve dysplasia, and deafness with inner ear malformations.

194 28 following blast, and are associated with inner ear mechanotransduction, cytoskeletal reorganizati

195 inkers and suggests how they may function in inner-ear mechanotransduction, with implications for oth

196 darker-skinned individuals tend to have more inner ear melanin, and cochlear melanocytes are importan

197 ence that noise exposure leads to changes in inner ear metabolism, the specific effects of noise expo

198 owerful approach for the characterization of inner ear metabolites affected by auditory trauma.

199 g evidence of an essential role for MEKK4 in inner ear morphogenesis and identifies the requirement o

200 function of let-7 in HC differentiation and inner ear morphogenesis.

201 naptic activities, nervous system processes, inner ear morphology, and cognition, while genetic corre

202 spective study including patients who had an inner ear MRI for two months.

203 Inner ear MRI without contrast gives relevant informatio

204 Here we tested SOX2's requirement during inner ear neuronal specification using a conditional del

205 ion of the Wnt receptor, Frizzled3 (Fzd3) in inner ear neurons.

206 Cisplatin stimulates GSTA4 activity in the inner ear of female wild-type, but not male wild-type mi

207 BE3 RNPs into both zebrafish embryos and the inner ear of live mice to achieve specific, DNA-free bas

208 Examples from the inner ear of mammals and bushcrickets demonstrate that s

209 s cDNA by the adenoassociated virus 8 to the inner ear of newborn mutant mice reestablishes the expre

210 iency, we delivered wild-type Ush1c into the inner ear of Ush1c c.216G>A mice using a synthetic adeno

211 by removing 4-hydroxynonenal (4-HNE) in the inner ears of female mice.

212 The middle and the inner ears of WT and Nhe6 KO mice were not different mor

213 neration is induced by laser ablation in the inner ear or by neomycin treatment in the lateral line,

214 We discuss how inner ear organoids have been developed and how they off

215 ferentiating human pluripotent stem cells to inner ear organoids that harbor functional hair cells.

216 Over 2 months, the vesicles develop into inner ear organoids with sensory epithelia that are inne

217 could have facilitated the emergence of new inner ear organs and their functional diversification in

218 y role played by the two low-frequency-tuned inner-ear organs in anuran amphibians - the amphibian pa

219 acoustic Ganglion (SAG), which innervate the inner ear, originate as neuroblasts in the floor of the

220 ion of adgrg6 also results in defects in the inner ear: otic tissue fails to down-regulate versican g

221 Since inner ear outer hair cell (OHC) degeneration is a common

222 work, we have shown that miRNA profiling in inner ear perilymph is feasible and may demonstrate dist

223 nt effect that genetic background has on the inner ear phenotype of Atp6v1b1 mutant mice provides ins

224 The abnormal inner ear phenotype of MRL- Atp6v1b1vtx/vtx mice was los

225 Spontaneous activity in the inner ear plays a critical role in guiding this maturati

226 The otocyst, an anlage of the inner ear, presents an attractive target to study treatm

227 recombinase in the Gfi1(Cre) mouse neonatal inner ear, primarily in inner ear resident macrophages,

228 mptive correction of a mutation in the fetal inner ear prior to maturation of the sensory epithelium

229 d resolution to obtain information about the inner ear prior to performing surgery.

230 o-activation of cell cycle activator Myc and inner ear progenitor gene Notch1 induces robust prolifer

231 transcription factor complex in maintaining inner ear progenitors during development, and suggest ne

232 Specification of inner ear progenitors is initiated by FGF signalling.

233 n partner-like 5 (Lhfpl5), and Transmembrane inner ear protein (Tmie).

234 CANCE STATEMENT Vestibular end organs in the inner ear receive efferent inputs from the brainstem.

235 tnatally and may have broad implications for inner ear regenerative therapies.

236 bone powder, and confines the damage to the inner ear region and surface of the petrous portion of f

237 Sensory perception in the inner ear relies on the hair bundle, the highly polarize

238 r downstream transcriptional cascades in the inner ear remain largely unknown.

239 faces with high anatomic detail, such as the inner ear, remain a challenge.

240 sease as well as regenerative mechanisms for inner ear repair.

241 (Cre) mouse neonatal inner ear, primarily in inner ear resident macrophages, which outnumber the hair

242 Hair cells, the sensory receptors of the inner ear, respond to mechanical forces originating from

243 ls (HCs) are the mechanoreceptors within the inner ear responsible for our sense of hearing.

244 The vertebrate inner ear, responsible for hearing and balance, is able

245 her, conditional loss of the Yap gene in the inner ear results in the formation of significantly smal

246 ice limits CHD7 expression in the developing inner ear, retina and brain.

247 his prediction, analysis of developing chick inner ear revealed that ligand-producing hair cell precu

248 These emissions are an epiphenomenon of the inner ear's active process, which enhances the auditory

249 n of ~P23 mouse vestibular hair bundles, the inner ear's sensory organelle.

250 Because dimension control of the inner ear's stereocilia is particularly precise, we stud

251 y where the peripheral otolith organs in the inner ear sense both head tilts and translations.

252 Inner ear sensory afferent connections establish sensory

253 Inner ear sensory epithelia contain mechanosensitive hai

254 ral gene delivery of Yap5SA in the postnatal inner ear sensory epithelia in vivo drives cell cycle re

255 In the inner ear sensory epithelia, stereociliary hair bundles

256 cells are coordinately oriented within each inner ear sensory organ to exhibit a particular form of

257 lesce to form the neurons that innervate all inner ear sensory regions.

258 structural determinants of tip-link-mediated inner-ear sensory perception and elucidate protocadherin

259 d cytotoxicity.SIGNIFICANCE STATEMENT In the inner ear, sensory hair cells signal reception of sound.

260 rmation of kidney and intestinal microvilli, inner ear stereocilia, immune synapses, endocytic patche

261 ic sac is required for acquisition of normal inner ear structure and function.

262 acellular proteins, as egg coat proteins and inner ear tectorins.

263 hanism of intercellular communication in the inner ear that can mediate nonautonomous hair cell survi

264 the specialized mechanosensory cells of the inner ear that capture auditory and balance sensory inpu

265 cells are specialized sensors located in the inner ear that enable the transduction of sound, motion,

266 ted calcium channel (Ca(V)1.3) in the pigeon inner ear that has been shown to mediate electroreceptio

267 ROS) within mechanosensory hair cells of the inner ear that have been implicated in hearing and balan

268 ts, such as the cochlear part of the osseous inner ear, that provides optimal contexts for DNA preser

269 solated from three compartments of the mouse inner ear - the vestibular and cochlear sensory epitheli

270 In the inner ear, the deflection of hair bundles, the sensory o

271 is performed by specialized receptors of the inner ear, the hair cells.

272 skin differentiation and carcinogenesis, the inner ear, the lung and the retina.

273 Notably, vestibular sensory organs of the inner ear, the maculae, exhibit a line of polarity rever

274 We conclude that, in the inner ear, the noncoding del10 mutation in Hgf leads to

275 In the inner ear, these acoustic receptors are primarily attach

276 The derivation of human inner ear tissue from pluripotent stem cells would enabl

277 of the JCI, Breglio et al. demonstrate that inner ear tissue released exosomes carrying heat shock p

278 In response to heat stress, inner ear tissue releases exosomes that carry HSP70 in a

279 Secondarily, we find that inner ear Tmc gene therapy restores breeding efficiency,

280 uxiliary subunit, which can be transmembrane inner ear (TMIE) or TMEM132e.

281 tential of molecular agents delivered to the inner ear to ameliorate different types of SNHL.

282 mmals owing to the inability of cells in the inner ear to proliferate and replace lost sensory recept

283 field generated by the sensory cells of the inner ear to serve as a sound source microphone for full

284 large morphotype, including its endocast and inner ear, to reveal its morphology for the first time.

285 ein complex, which conveys force to open the inner-ear transduction channels that mediate sensory per

286 tiles shows how minute balance organs in the inner ear transformed at the same time.

287 V2/9 as a novel and atraumatic technique for inner ear transgene delivery in early postnatal mice.

288 r cells, the mechanosensory receptors of the inner ear, underlie the senses of hearing and balance.

289 ructural and molecular changes in the middle/inner ears utilizing otoscopy, RNA sequencing (RNA-seq),

290 into organoids that morphologically resemble inner ear vestibular organs.

291 5-aza was administrated into the mouse inner ear via the round window.

292 s morphology and structure of the pwi larval inner ear was near normal, acoustic startle stimuli evok

293 roles of this Tmc subfamily in the zebrafish inner ear, we tested the effects of truncating mutations

294 Inner ears were harvested immediately after exposure and

295 lian intracochlear anatomy, fixed guinea pig inner ears were imaged as whole temporal bones with coch

296 Mechanosensory organs, such as the inner ear (which houses senses of equilibrium and hearin

297 s occurs in the hair-cell stereocilia of the inner ear, which experience continuous oscillations driv

298 ntration of iron within the labyrinth of the inner ear, which might indirectly tune a magnetic sensor

299 urements have previously been available from inner ears with intact low-frequency parts.

300 In the inner ear, Zpld1 mRNA expression was detected only in th