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1 inhibits premature cyclase activation in the inner segment.
2 of early redistribution of cone opsin to the inner segment.
3 hodopsin mislocalization in membranes of the inner segment.
4 Ca2+ conductance (gCa) in the photoreceptor inner segment.
5 ith membranes and instead accumulated in the inner segment.
6 orporation of molecules transported from the inner segment.
7 of post-Golgi rhodopsins retains them in the inner segment.
8 tors consist of an outer segment (OS) and an inner segment.
9 ceptors and the periciliary extension of the inner segment.
10 ty is present almost exclusively in the cone inner segment.
11 mtDNA damage, primarily in the photoreceptor inner segments.
12 nd inner plexiform layers, and photoreceptor inner segments.
13 The IR is predominately expressed in rod inner segments.
14 increase was localized to the photoreceptor inner segments.
15 tic terminals and became undetectable in the inner segments.
16 sorganization of the photoreceptor outer and inner segments.
17 not dock properly at the apical edge of the inner segments.
18 in, but only in moving from the outer to the inner segments.
19 plexiform layer as well as to photoreceptor inner segments.
20 ssed constitutively on RPE and photoreceptor inner segments.
21 y on RPE and in high levels on photoreceptor inner segments.
22 ression in the photoreceptor cell bodies and inner segments.
23 e it appeared to be most concentrated in the inner segments.
24 Cone cells in the periphery had remnants of inner segments.
25 ferentiation and was immediately targeted to inner segments.
26 xtracellular vesicles surrounding the distal inner segments.
27 toreceptors, localizing predominantly in the inner segments.
28 e ERG are truncated with shortened outer and inner segments.
29 are retinal cells, especially photoreceptor inner segments.
30 t closely resembles rdgC is localized to rod inner segments.
31 iched in biochemical extracts of retinal rod inner segments.
32 tae openings align with those of neighboring inner segments.
33 tive stress was noted in their photoreceptor inner segments.
34 9-1 and Gbeta5L are primarily located in rod inner segments.
35 GS9-1 from R9AP and redistributing it to rod inner segments.
36 ary dendrites and HR2 mRNA was found in cone inner segments.
37 uperior central retina, within photoreceptor inner segments, 24 hours after light treatment, but decl
40 s a role in the assembly or stabilization of inner segment and calycal process actin filament bundles
42 toresponse, mislocalization of ATP8A2 to the inner segment and cell body, and increased apoptosis in
44 with GTP-locked mutants concentrated in the inner segment and GDP-locked mutants concentrated in the
45 remaining P23H-hRho-GFP mislocalizes to the inner segment and outer nuclear layer, with only approxi
46 In control mice REEP6 was localized to the inner segment and outer plexiform layer of rod photorece
48 attachment of the ERM (P = .003), and foveal inner segment and outer segment junction disruption (P =
50 ion of vacuole-like structures at the apical inner segment and reduction in selected rod phototransdu
52 ically, IMPDH1 is found predominately in the inner segment and synaptic terminals of retinal photorec
53 in and the ribbons in hair cells, and in the inner segment and the axon of the photoreceptor, consist
54 sed by protein transport defects between the inner segment and the outer segment of the photoreceptor
55 calization and aggregation of S-opsin in the inner segment and the synaptic region of rods, ER stress
56 identified that rhodopsin accumulates in the inner segments and around the nucleus of photoreceptors.
57 soform of Hmgb1 was present in photoreceptor inner segments and bound to a membrane fraction with cha
61 ation of apical cell features: photoreceptor inner segments and cilia in renal and auditory systems.
62 affects retinoid metabolism in photoreceptor inner segments and delays the kinetics of dark adaptatio
64 genes at the cell membranes of photoreceptor inner segments and Muller cell apical processes in the z
66 erly, and some OS markers mislocalize to the inner segments and outer nuclear layer in the Nphp4(nmf1
67 enolase1 co-localized with arrestin1 in the inner segments and outer nuclear layer, but remained in
68 crystallin localization in the photoreceptor inner segments and outer plexiform layer in the WT contr
69 retina, where it was localized mostly in the inner segments and outer plexiform layer of photorecepto
70 Muller and RPE cells that extend between the inner segments and outer segments of photoreceptors, res
73 birth; in the adult, PMCA2 was expressed in inner segments and synaptic terminals of rod photorecept
74 imilarly in the outer retina, especially the inner segments and synaptic terminals of rod photorecept
80 ow that RDH12 localizes to the photoreceptor inner segments and that deletion of this gene in mice sl
81 n, cGK I mRNA was localized to photoreceptor inner segments and the ganglion cell and inner nuclear l
82 MrdgB protein is localized to photoreceptor inner segments and the outer and inner plexiform layers.
83 s showed DRAM2 localization to photoreceptor inner segments and to the apical surface of retinal pigm
86 retinas, ZBED4 was localized to cone nuclei, inner segments, and pedicles, as well as to Muller cell
88 d mitochondrial Ca2+ stores in photoreceptor inner segments, and suggest a role for CICR in the regul
91 ha-GTP complex capable of diffusing from the inner segment back to the outer segment after light-indu
92 or weakly positive before ED13, appeared in inner segments between ED13 and ED15, became subsequentl
94 mb prevents targeting of Cng channels to the inner segment, by promoting their trafficking through th
97 psin immunolabeling was also observed in the inner segment, cell body, axon, and axon terminal of pho
98 tissue revealed that MAK is expressed in the inner segments, cell bodies, and axons of rod and cone p
100 y), outer nuclear layer (ONL) (nasally), and inner segment (centrally and temporally) were found in p
103 us, sensitization of the photovoltage by rod inner segment conductances appears to extend the operati
104 ment could not be explained by modulation of inner segment conductances or the voltage sensitivity of
105 sin-II is a molecular motor localized to the inner segment, connecting cilium and axoneme of mammalia
106 tor cells, actin and TULP1 colocalize at the inner segment, connecting cilium, and outer limiting mem
108 gments were short and disorganized and their inner segments contained stacks of rhodopsin-positive me
109 f free [3H]DHA from ROS to the photoreceptor inner segment contributed to an additional overall incre
113 inal during synaptic transmission and at the inner segment during protein translocation to the outer
114 dopsin (RHO), which severely mislocalized to inner segments during the initial stage of degeneration.
115 nce from the fovea to the location where the inner segment ellipsoid (ISe) band became undetectable w
117 d into 5 distinct categories: (1) continuous inner segment ellipsoid (ISe), (2) ISe disruption, (3) I
119 la demonstrated complete preservation of the inner segment ellipsoid band in 1 patient, with variable
122 ipsoid reflectivity (defined as the ratio of inner segment ellipsoid band reflectivity on overall ret
124 inner segment-outer segment junction or the inner segment ellipsoid band was disrupted within 1 degr
126 ct outer retina; stage 2 (2 patients [12%]), inner segment ellipsoid line disruption; stage 3 (5 pati
128 y, global retinal reflectivity, and relative inner segment ellipsoid reflectivity (defined as the rat
129 he annual rate of change in the width of the inner segment ellipsoid zone (EZ; ie, inner/outer segmen
130 igment epithelium (RPE) band, grading of the inner-segment ellipsoid (ISe) band integrity, and presen
131 TP1 showed specific labeling of rod and cone inner segments, especially in the mitochondria-rich elli
132 velopment leads to opsin accumulation in the inner segment even when the connecting cilium and outer
139 g outer segment light-dependent channels and inner segment hyperpolarization-activated cyclic nucleot
140 s were immunopositive for TRPC1 whereas cone inner segments immunostained with TRPC6 channel antibodi
141 um regulation in the photoreceptor outer and inner segments implies that transduction and synaptic si
143 analysis, Pd is found almost entirely in the inner segment in both light and dark, most abundantly ne
145 e arrangement of the mitochondria within the inner segment in detail using three-dimensional (3D) ele
146 rding technique and recorded from single rod inner segments in isolated intact neural mouse retinae,
147 Ultrasturctural analysis revealed intact inner segments in light-treated retinas, whereas in untr
148 tet-ARR1), stored in the outer nuclear layer/inner segments in the dark, modulates photoreceptor syna
149 Electron microscopic observations of rat rod inner segments indicated generally excellent survival of
150 dies revealed a mosaic of cone photoreceptor inner segments indistinguishable from that of neonatal r
151 14 months, including improved rod outer and inner segment integrity, less photoreceptor cell loss, a
152 However, RDH12 function in the photoreceptor inner segments is also key, because loss of function mut
154 major retinal layers being visible, and both inner segment (IS) and outer segment (OS) length were wi
156 le fiber outer nuclear layer (HFONL) and the inner segment (IS) layer, but not in the inner nuclear l
157 proteins from their site of synthesis in the inner segment (IS) to the outer segment (OS) is critical
158 ro-tetramers with Rom-1 in the photoreceptor inner segment (IS), while higher-order, disulfide-linked
159 her photoreceptor compartments including the inner segments (IS) and synaptic terminals (ST) is recog
160 al antibody showed staining localized to the inner segments (IS) of photoreceptor cells, as well as t
162 ion in length and broadening of rod and cone inner segments (IS) was next observed, followed by the f
163 outer plexiform (OPL) layers, photoreceptor inner segments (IS), and retinal pigment epithelium (RPE
165 he plasma membrane (PM) of rod photoreceptor inner segments (ISs), and causes autosomal dominant RP.
167 cetacoplan exhibited a thicker photoreceptor inner segment layer along the 5.16 degrees -contour-line
168 sin was sequestered to the photoreceptor rod inner segment layer with a concomitant increase in photo
169 e ONL and that of the rod outer-segment plus inner-segment layer were measured at several points alon
170 In its absence, rod photoreceptor outer and inner segment length was reduced, and cone cell numbers
171 hondria are elongated and extend most of the inner-segment length, where they supply energy for prote
172 ause retention of ABCA4 in the photoreceptor inner segment, likely by impairing correct folding, resu
173 of stable rhodopsin/arrestin complex in the inner segment may be an important mechanism for triggeri
174 ecting cilium and consequent accumulation of inner segment membrane proteins in the outer segment, al
177 Due to the often close proximity to the inner-segment mitochondria, they may, too, play a role i
179 ochondria, they may, too, play a role in the inner-segment mitochondrial arrangement as well as metab
182 Grb14 is localized predominantly to the inner segment, nuclear layer, and synapse in dark-adapte
183 f Phd isoforms with CRX predominantly in the inner segment of cone cells, with additional costaining
184 rences in the localization of RNA within the inner segment of cone photoreceptors, suggesting that mo
187 bonate exerted an effect when applied to the inner segment of rods but had little efficacy when appli
190 l layer, inner and outer nuclear layers, and inner segments of photoreceptor cells in all 17 eyes.
191 the day and night was in the vicinity of the inner segments of photoreceptor cells, supporting the id
193 cein-conjugated PEDF stained exclusively the inner segments of photoreceptors and cells of the gangli
194 trans-retinaldehyde, which diffuses into the inner segments of photoreceptors from illuminated rhodop
195 and human retinas, NOS-1 is expressed in the inner segments of photoreceptors, cells in the inner nuc
196 ccumulation of intracellular vesicles in the inner segments of photoreceptors, whereas immunohistoche
197 s, C.O. and NOS levels were both high in the inner segments of retinal photoreceptor cells where ener
198 Intensity of the GCAP1-IR was strong in inner segments of rods in all species but weaker in oute
200 that GFP was predominantly localized to the inner segments of the major rods; a smaller amount was i
202 ayers of the retina but in neither outer nor inner segments of the photoreceptor layers in mice beari
203 d expression pattern but is expressed in the inner segments of the photoreceptors whilst Cds2 shows a
209 mbrane (INL-ELM); external limiting membrane-inner segment outer segment (ELM-ISOS); and inner segmen
210 -inner segment outer segment (ELM-ISOS); and inner segment outer segment-retinal pigment epithelium (
211 demonstrate that disruption of photoreceptor inner segment-outer segment (ellipsoid) layer on SD-OCT
212 fluid, size and location of cystoid changes, inner segment-outer segment (IS-OS) continuity, quantity
213 Retinal sensitivity over lesions with intact inner segment-outer segment (IS-OS) junction was 13.35 +
214 yer (ONL), external limiting membrane (ELM), inner segment-outer segment (IS-OS) junction, outer phot
215 rence of several abnormalities, for example, inner segment-outer segment alterations were found in 60
216 E nodularity (8%), photoreceptor loss (43%), inner segment-outer segment junction (IS-OS) irregularit
219 rence tomography (SD-OCT), disruption of the inner segment/outer segment (IS/OS) band, and thinning o
220 ellipsoid (ISe) band, previously called the inner segment/outer segment (IS/OS) border, seen on opti
222 red autofluorescence patterns, the status of inner segment/outer segment (IS/OS) interface, and retin
223 ers evaluated the integrity of photoreceptor inner segment/outer segment (IS/OS) junction and externa
225 OCT data showed a loss of the photoreceptor inner segment/outer segment (IS/OS) junction in the cent
226 d on 8 eyes and the horizontal extent of the inner segment/outer segment (IS/OS) junction was measure
228 ild-type mice demonstrated visibility of the inner segment/outer segment (IS/OS) junction, external l
229 macular defects, including disruption of the inner segment/outer segment and outer segment/retinal pi
235 SD OCT results with preserved photoreceptor inner segment/outer segment junction, whereas this junct
241 ted (Cng) channels, which accumulates on the inner segment plasma membrane in addition to its normal
243 sruption of the myosin-tail homology domain, inner segment plasma membrane proteins, including syntax
244 ated primarily with the outer leaflet of the inner segment plasma membrane through anionic phospholip
247 iles in the interphotoreceptor space and the inner segment plasma membranes are immunoreactive for rh
251 estricted membrane microdomain at the apical inner segment recess that wraps around the connecting ci
253 sis during development, to be present in the inner segment region of these postmitotic cells in sever
256 er (mean 47, range 20-76 ppm), photoreceptor inner segments (RIS) ellipsoid zone, outer limiting memb
257 mistry, ZCRDH was abundantly present in cone inner segments, similar to the reported distribution of
258 t GCIP identified high levels of GCIP in the inner segments, somata and synaptic terminals of frog co
259 dult retinas, anti-TULP1 labels cone and rod inner segments, somata, and synapses; outer segments are
260 g with anti-GCAP2 antibodies was in the cone inner segments, somata, and synaptic terminals and, to a
261 ucin translocates from rod outer segments to inner segments/spherules in bright light, but the functi
263 nstitutive GITRL expression on photoreceptor inner segments suggests that photoreceptors participate
264 fter methanol intoxication, with evidence of inner segment swelling and mitochondrial disruption.
265 ium regulation in the outer segment (OS) and inner segment/synaptic terminal (IS/ST) regions of rods
266 kre oko photoreceptor cells, including their inner segments, the nuclear regions, and the synaptic te
267 r photoreceptors are present in the cavefish inner segments, the outer segments of the photoreceptors
268 is localized primarily in the photoreceptor inner segments, the site of mitochondrial oxidative stre
269 lace at or near the plasma membrane from the inner segment through the connecting cilium into the out
270 ransported from the site of synthesis in the inner segment through the connecting cilium, followed by
271 within the rod photoreceptor cells from the inner segments, through the rod nuclei to the rod photor
272 ed GFP immunoreactivity in rod photoreceptor inner segments throughout the retina, indicating the rod
277 ng PDE6) from their site of synthesis in the inner segment to their final destination in the outer se
278 achment, severely reduces the ability of the inner segments to obtain O(2), even for detachment heigh
279 ique, nonredundant role in the photoreceptor inner segments to regulate the flow of retinoids in the
280 nts aberrant transport of rhodopsin from the inner segments to the nascent disc membranes of the oute
281 to light, a leak of retinoids from outer to inner segments was detected in rods from both wild-type
282 etina due to shortening of the rod outer and inner segments was observed when compared to control lit
286 and outer nuclear layer, but remained in the inner segments when arrestin1 translocated in response t
287 nol is transported from Muller cells to cone inner segments, where it is oxidized to 11-cis-retinal.
288 rder neurons and, to a lesser extent, to the inner segments, where polarized protein translocation oc
289 ghly expressed in rod and cone photoreceptor inner segments, where they shape the light response, mut
290 s mostly restricted to the rod photoreceptor inner segments, whereas GCAP1 immunofluorescence was con
291 e localized exclusively in the photoreceptor inner segments, which are known to be densely populated
292 ntral cones had 2-microm-wide outer (OS) and inner segments, which came straight off the cell body.
293 conditions require a large O(2) flux to the inner segments, which in turn requires high choroidal ox
295 stin, and membranes within the photoreceptor inner segment, while the localization of alpha-transduci
296 scopy showed increased autophagosomes in rod inner segments with HDAC inhibitor (HDACi) treatment, po
298 dentified as cones by dual labeling of their inner segments with the lectin peanut agglutinin or by c
299 s the majority of recoverin was found in rod inner segments, with approximately 12% present in the ou
300 e most intense immunolabeling was in the rod inner segments, with weaker labeling of cone myoids, som