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1  coupling by gap junctions composed of UNC-9/Innexin.
2 tebrate electrical synapse constituents, the innexins.
3  structure-function analyses of invertebrate innexins.
4 xin genes into the large family of planarian innexins.
5 that superseded the gap junction function of innexins.
6                           We discovered that innexin 1 (INX-1), a gap junction protein that forms ele
7 tify genes (e.g. Tomosyn, Chitinase 5, Adar, Innexin 2, Transferrin 1, Sick, Oatp26F) and Gene Ontolo
8                                     Instead, Innexins 2 and 3 function within the border cells, and I
9  and 3 function within the border cells, and Innexin 4 functions within the germline, to regulate mic
10 es a germline-specific gap junction protein, Innexin 4, that is required for survival of differentiat
11 ortholog of the Drosophila gap junction gene Innexin 7, leads to failure of cellularization.
12   These data demonstrate a critical role for innexin AGAP001476 in mediating innate immune responses
13                                              Innexin AGAP001476 mRNA levels in midguts were induced d
14 which share several structural features with innexin and pannexin proteins.
15                   Examples include connexin, innexin and pannexin, which form gap junctions and/or bo
16 g approaches to uncover the contributions of Innexins and microtubules to a cell-biological process i
17 ty and 39-66% similarity to other Drosophila innexins and share a similar hydrophobicity profile.
18                                 Invertebrate innexins and their mammalian homologues, the pannexins,
19 s with connexins and evolutionarily distinct innexins and their vertebrate pannexin homologs.
20  with a similar topology, such as connexins, innexins and volume-regulated anion channels(4-8).
21 rge-pore forming proteins such as connexins, innexins, and LRRC8, pannexins have minimal sequence sim
22  pharynx, providing supporting evidence that innexins are components of gap junctions.
23 ordate innexins indicating that glycosylated innexins are not a novelty of chordates.
24   Thus, CALHMs, connexins, and pannexins and innexins are structurally related protein families with
25                                              Innexins are the proposed structural components of gap j
26                                              Innexins are the subunits of invertebrate gap junctions.
27 provide a relatively detailed description of innexin-based gap junctions in a native tissue and sugge
28 ed fate by GJC loss-of-function suggest that innexin-based GJC mediates instructive signaling during
29 unctions in a native tissue and suggest that innexin-based small conductance gap junctions can play a
30                        A cell type-specific "innexin code" coordinates wave propagation through a def
31                                              Innexins compose gap junctions in invertebrates and affe
32 ses formed by the gap junction protein INX-1/innexin couple the presynaptic terminals of a pair of mo
33         In addition, we discovered a loss of innexin diversity during early chordate evolution.
34     Transgenic expression of the appropriate innexins during pupal development (but not later) rescue
35  CLA-1, RAB-3, GRASP (chemical synapses), or innexin (electrical synapse) reporters.
36 FoxO transcription factors mediating dynamic innexin expression plasticity in a neuron-type- and envi
37                                              Innexin expression was detected throughout the animal, a
38                                    Planarian innexins fall into 3 groups according to both sequence a
39 he recent identification of the invertebrate innexin family opens up powerful genetic systems to stud
40                                         Here Innexins form junctions to facilitate adhesion between t
41 e, we identified glycosylation sites of 2388 innexins from 174 non-chordate and 276 chordate species.
42  tip cell (DTC) and Sh1, and we show that an innexin fusion protein used in a prior study encodes an
43 ation and characterization of smedinx-11--an innexin gap junction channel gene expressed in the adult
44                                 We found the Innexin gap junction proteins are present between differ
45  here that a transient network formed by the innexin gap-junction protein NSY-5 coordinates left-righ
46                  This study examined whether innexins, gap junction proteins in insects, are involved
47 oned and characterized the expression of the Innexin gene family during planarian regeneration.
48                                          The Innexin gene family forms gap junctions in invertebrates
49 ystem are assembled from two products of the innexin gene shaking-B.
50 aryngeal pumping via a pathway involving the innexin gene unc-7 and components of the glutamatergic p
51                        We show here that the innexin gene unc-9 is required in RMG hub neurons to dri
52 ping suggests diversification of 3 ancestral innexin genes into the large family of planarian innexin
53           Here we investigate two Drosophila innexin genes, Dm-inx2 and Dm-inx3 and show that they ar
54 e maturation, we performed an RNAi screen of innexin genes, which encode channel-forming proteins.
55                           Chordates retained innexin-homologs, but N-glycosylation prevents them from
56  established and we investigated the role of Innexins in mediating glial function in the Drosophila p
57                          Nerve cell-specific innexins indicate that gap junctions can provide this sp
58  motif is also widespread among non-chordate innexins indicating that glycosylated innexins are not a
59 thodology allows us to infer a network of 19 innexin interactions that govern the formation of gap ju
60                        Here we show that the innexin INX-14 promotes sperm guidance to the fertilizat
61              This wave is propagated via the innexin INX-16, likely by calcium influx.
62                            Fifteen of the 21 innexin (Inx) genes (Hve-inx) found in the genome of the
63 se results reveal that expression of certain innexins is sufficient to couple individual neurons to p
64  may connect with hemichannels made of other innexin isoforms on adjacent somatic cells.
65      Live calcium imaging reveals that inx-1/innexin mutations lead to asynchronous activation of AVL
66 no evolutionary linkages including connexin, innexin, pannexin, leucine-rich repeat-containing 8 (LRR
67  channels to the more recent developments in innexin, pannexin, LRRC8, and CALHM.
68  the homologous mouse gene Panx1 gene, thus, innexin/pannexin proteins may play broadly conserved rol
69           Connexins are unique to chordates; innexins/pannexins encode gap-junction proteins in prech
70 exins, which are exclusive to chordates, and innexins/pannexins, which are found throughout the anima
71                               Members of the innexin protein family are structural components of inve
72 fically recognize the Caenorhabditis elegans innexin protein INX-3 were generated and used to examine
73     We show that hemichannels containing the innexin protein UNC-7 are also essential for gentle touc
74 sh among gap junctions composed of different Innexin proteins (is not subject to compensation or redu
75             We identify gap-junction-forming innexin proteins as critical.
76 mediated by the central nervous system and 3 innexin proteins, which determine the fate and axial pol
77 sing targeting of the gap junctional protein innexin shaking-B to gap junctions (GJs).
78  transmembrane domain (M1) of the Drosophila innexin Shaking-B(Lethal), which is a component of recti
79 es with mutations in the gap junction genes (innexins), shakingB, and ogre have normal photoreceptor
80 our homologues of insect gap junction genes (innexins) termed vinnexins, which are expressed in multi
81  is mediated by a gap junction protein UNC-9/Innexin, that is localized at the presynaptic tiling bor
82                  Pannexins are homologous to innexins, the invertebrate gap junction family.
83  proteins that exhibits sequence homology to innexins, the invertebrate gap junction proteins, and wh
84 ins in mammals, and 3 pannexins, homologs of innexins, the main gap junction forming proteins in inve
85 nctions with antibodies to Shaking-B (ShakB) Innexin, they were significantly decreased or absent in
86 dates should exist that use non-glycosylated innexins to form gap junctions.
87                                          The innexin UNC-9 appeared to be a key component of the gap
88                      Of the eight Drosophila Innexins, we found two (Inx1 and Inx2) are important for
89             Non-chordates use the primordial innexins, while chordates use connexins that superseded
90 xclusively possess only one highly conserved innexin with one glycosylation site.
91   Among all chordates, we found not a single innexin without glycosylation sites.