ライフサイエンスコーパス: innocuous

1 ined stimulation that is subthreshold (i.e., innocuous).

2 roscopy often is considered to be relatively innocuous.

3 f electronic cigarettes has not proven to be innocuous.

4 evaluating whether a stimulus is noxious or innocuous.

5 carries (ilvG rfb-50 rph-1) were considered innocuous.

6 ure stimuli, which normally are perceived as innocuous.

7 onal combustion cigarettes, but they are not innocuous.

8 ile other aggregates appear to be relatively innocuous.

9 development of immune responses to otherwise innocuous aeroallergens and foods.

10 also central to noninflammatory clearance of innocuous agents.

11 ibrils are chemically indistinguishable from innocuous aggregates and monomeric precursors, their det

12 2), may promote adaptive immune responses to innocuous Ags that are not by themselves immunostimulato

13 led pathogens while maintaining tolerance to innocuous Ags.

14 lymphopoietin sensitized naive animals to an innocuous airway Ag OVA, which resulted in production of

15 This work showcases how seemingly innocuous ALD can evolve into a CVD process when the pro

16 y tone and preventing hyperresponsiveness to innocuous allergen.

17 inappropriately directed towards relatively innocuous allergens resulting in conditions including as

18 onal NIRS to evaluate brain activation to an innocuous and a noxious electrical stimulus on healthy h

19 eloped putative rat model of fibromyalgia to innocuous and acute nociceptive stimuli by applying a st

20 or Na(V)1.8-negative neurons in sensing both innocuous and acute noxious cooling down to 1 degrees C,

21 metal catalysts or ligands, and it produces innocuous and easy-to-remove by-products.

22 ly, integration of mechanosensory input from innocuous and nociceptive sensory neurons is required fo

23 that dietary exposure to the metabolites is innocuous and not an ideal measure of exposure to the pa

24 inal cord processing and reflex responses to innocuous and noxious colorectal stimuli in female rats

25 ll mice have strong deficits in responses to innocuous and noxious heat but not in other sensory moda

26 ere injected with estrogen, and responses to innocuous and noxious intensities of CRD were measured b

27 Neuronal and behavioral responses to innocuous and noxious mechanical stimulation were tested

28 - and off-cells in the RVM are sensitized to innocuous and noxious mechanical stimuli after nerve inj

29 Knowing the difference between innocuous and noxious mechanical stimuli is critical for

30 lations and hyperexcitable responsiveness to innocuous and noxious peripheral stimuli in unit recordi

31 arge, afterdischarge, hyperresponsiveness to innocuous and noxious peripheral stimuli, and expansion

32 channel activated by hot temperatures in the innocuous and noxious range.

33 d the first description of the processing of innocuous and noxious stimuli throughout the intact DH.

34 For both innocuous and noxious stimuli, we observed a signal chan

35 Differential encoding of innocuous and noxious thermal and mechanical stimuli wer

36 lations that transmit information about both innocuous and painful touch and inhibitory populations t

37 estinal epithelial cells are exposed to both innocuous and pathogenic microbes, which need to be dist

38 between self and non-self, but also between innocuous and pathological foreign antigens to prevent u

39 al and deeper T9-T10 spinal neurons received innocuous and/or noxious convergent inputs from mechanic

40 two distinct types of touch stimuli: gentle (innocuous) and harsh (noxious/painful) touch, however, t

41 d simultaneously B and T cell immunity to an innocuous antigen inhaled concurrently.

42 ipheral dendritic cells (DCs) that transport innocuous antigens (Ags) to the thymus for presentation

43 required to maintain local tolerance against innocuous antigens in the lung but powerfully licenses c

44 reventing inappropriate immune reactivity to innocuous antigens include deletion of reactive lymphocy

45 inappropriate responses to the background of innocuous antigens is essential for understanding and tr

46 r site where immune tolerance to circulating innocuous antigens occurs, the kidney also contributes.

47 The lung is exposed to a myriad of innocuous antigens on a daily basis and must maintain a

48 Allergens are mostly innocuous antigens that elicit powerful T helper cell ty

49 in a high threshold of immune 'ignorance' to innocuous antigens to avoid inflammatory disease that de

50 gulated to limit pathologic responses toward innocuous antigens while simultaneously allowing for rap

51 surrounding materials, including harmful and innocuous antigens, at the environmental interface.

52 Ingestion of innocuous antigens, including food proteins, normally re

53 prevent unwanted inflammation in response to innocuous antigens, while maintaining the ability to com

54 involved in the maintenance of tolerance to innocuous antigens.

55 h IL-17 and IL-22 responses directed against innocuous antigens.

56 erizes the immune system against circulating innocuous antigens.

57 h Th2 adaptive immune responses triggered by innocuous antigens.

58 the control of autoimmunity and tolerance to innocuous antigens.

59 are tightly controlled to limit responses to innocuous antigens.

60 hways involved in the sustained tolerance to innocuous antigens.

61 Though seemingly innocuous, appending nanoparticles with these radiolabel

62 They are usually considered sterile and innocuous as a result of nonsense-mediated mRNA decay.

63 of GABAergic neurons is important for gating innocuous as well as noxious information.

64 s renders the lung susceptible to a normally innocuous Aspergillus fumigatus fungus challenge, due to

65 ter process potentially rendering previously innocuous B cells autoreactive.

66 ronic infection of the airways with normally innocuous bacteria and fungi.

67 ng pathogens without affecting beneficial or innocuous bacteria harboring DXR should be feasible.

68 e fewer spontaneous seizures with relatively innocuous behavioral disorders.

69 ntly facilitated dural and noxious pinch and innocuous brush evoked firing from the TCC.

70 atory virus infection without illness is not innocuous but may determine the airway function of these

71 response to joint movement both noxious and innocuous, but only in the C-fibres was there an increas

72 se of their low oxidation potentials and the innocuous byproducts generated upon oxidation.

73 The eco-friendly, innocuous catalyst is compatible with a wide range of fu

74 otein-based) hardly distinguish between dead innocuous cells and their viable lethal counterparts.

75 induces atypical anoikis by transforming an innocuous cellular protein, Crk, into a cytotoxin, which

76 s the sequence of ARF, causing an apparently innocuous change near its carboxy terminus.

77 We reasoned that unlike innocuous channels, which are often short with multiple

78 Here we show, using the innocuous chemical 2,4-dinitrothiocyanobenzene (DNTB), t

79 t transforms toxic chlorite (ClO(2)(-)) into innocuous chloride and molecular oxygen.

80 Although initially assumed to be innocuous, chronic exposure to light at night (LAN) is n

81 enhanced sensitivity to mechanical force and innocuous cold temperatures.

82 istent with a potential TRPC5 function as an innocuous cold transducer in nociceptive and thermosenso

83 membrane currents evoked by both menthol and innocuous cold were significantly enhanced in the CCI gr

84 iveness of these neurons to both menthol and innocuous cold.

85 damage-triggered painful hypersensitivity to innocuous cold.

86 These results demonstrate that innocuous "cold" cornea thermoreceptors are activated by

87 These neurons were classified as innocuous "cold" thermoreceptors by their responses to s

88 The normally innocuous combination of aluminum and water becomes viol

89 also suggest the possibility that seemingly innocuous compounds may exert an adjuvant effect in huma

90 aromatic group in the derivative results in innocuous compounds, confirming that the aromatic-aromat

91 in the superficial and deep laminae than the innocuous control (30 degrees C).

92 sors are uniformly responsive to menthol and innocuous cool temperature (17 degrees C), indicating th

93 ve endings mediating distinct perceptions of innocuous cool, noxious cold, and first- and second-cold

94 ary cold sensors in humans, are activated by innocuous cooling (<28 degrees C) and cooling compounds

95 sponded to thermal stimuli, 50% responded to innocuous cooling as well as noxious heat and cold, 31%

96 Axons from cells responsive to innocuous cooling terminated in the core region of VPL,

97 cheobronchial tree, currently believed to be innocuous, could serve as an inflammatory stimulus, inde

98 In a separate experiment, the response to innocuous CRD was sensitized in estrogen-treated rats bu

99 In D6-deficient mice, otherwise innocuous cutaneous inflammatory stimuli induce a grossl

100 relevant air-water interface shift from the innocuous dehydroascorbic acid at biological pH to a C(4

101 tain tolerance toward commensal bacteria and innocuous dietary antigens.

102 Combination of innocuous dietary components with anticancer drugs is an

103 micronucleation in response to an otherwise innocuous dose of paclitaxel.

104 thal murine ehrlichial infection compared to innocuous ehrlichial infection.

105 Once thought of as innocuous, emerging evidence suggests that calcification

106 Chemically innocuous enantiotopic methyl groups are utilized as pro

107 tetrachloroethene and trichloroethene to the innocuous end product, ethene.

108 he development of aberrant responses against innocuous environmental Ags.

109 a is to maintain T cell tolerance to self or innocuous environmental antigens via its direct effects

110 IgE specific for innocuous environmental antigens, or allergens, binds an

111 xposed to a wide spectrum of fungi including innocuous environmental organisms, opportunistic pathoge

112 ve immune responses to ubiquitous, otherwise innocuous environmental proteins.

113 d organs, capturing self antigens as well as innocuous environmental proteins.

114 e of forming associations between previously innocuous events (e.g., being in a subway station) and a

115 Commonly occurring but seemingly innocuous events, such as yawning injury, should not be

116 ected type 2 immune responses against mostly innocuous exogenous compounds.

117 This seemingly innocuous feature challenges our current understanding o

118 IgE production against innocuous food antigens can result in anaphylaxis, a sev

119 ot retain DPA during heat or acid treatments innocuous for dormant spores, resulting in DPA-less spor

120 overlapping N- and O-glycosylation sites are innocuous for subunit biogenesis; however, mutation of T

121 vents pathological inflammatory responses to innocuous foreign antigens by peripheral regulatory T ce

122 Separating the innocuous from the disruptive exotic species provides a

123 pathogenic mutation or an equally rare, yet innocuous, genetic bystander.

124 we will need to learn to distinguish between innocuous genomic aberrations and those that may cause t

125 -lethal dose of Destruxin A and the normally innocuous Gram-negative bacteria Escherichia coli, showe

126 Here, we reveal that a historically innocuous grazer-the marsh crab Sesarma reticulatum-is r

127 tolerance induction in mice to the prototype innocuous hapten DNTB and suggest that strategies target

128 Therefore, the combination of ATRA and innocuous HDAC inhibitors may be expected to facilitate

129 al levels of "low innocuous heat," "moderate innocuous heat," "high innocuous heat," "low painful hea

130 uous heat," "moderate innocuous heat," "high innocuous heat," "low painful heat," "moderate painful h

131 , corresponding to perceptual levels of "low innocuous heat," "moderate innocuous heat," "high innocu

132 in and sequesters the released toxic heme as innocuous hemozoin crystals.

133 ilic cyclopropane of the colibactins into an innocuous hydrolysis product.

134 ways catalyzes oxidation of SCN(-) to tissue-innocuous hypothiocyanite (OSCN(-)), while consuming H(2

135 ical and chemical insults that are otherwise innocuous in healthy subjects or in patients with COPD,

136 ng immunocompromised hosts, for example, are innocuous in immune-competent individuals, and other mic

137 electrical forepaw stimulation, found to be innocuous in the control group.

138 system are relatively minor and, we predict, innocuous in vivo.

139 innate immune deviations following otherwise innocuous infections as a cause underlying the immune de

140 c immune deviations in response to otherwise innocuous infections have not been extensively explored.

141 milar to those involved in the processing of innocuous information and may be critically involved in

142 an adjuvant to allergically sensitize to an innocuous inhaled Ag.

143 onment, and in health, instruct tolerance to innocuous inhaled particles while ensuring that efficien

144 lated strong allergic airway responses to an innocuous inhaled protein, ovalbumin (OVA).

145 es are stable in air, and the byproducts are innocuous inorganic salts.

146 cant role in modulation of mechanosensitive, innocuous input than in nociception.

147 f ligands that can bind it amid an excess of innocuous ions in aqueous solution.

148 While it is normally innocuous, it has strong associations with atopic dermat

149 ile Mycobacterium avium was once regarded as innocuous, its high frequency as a cause of disseminated

150 , it is difficult to reconcile the seemingly innocuous kinetic alterations in I1768V as measured duri

151 ctive BCR through the expression of a second innocuous L chain.

152 cilitate integration, maintain an apparently innocuous latency, and/or establish conditions that are

153 , whereas hyperplastic polyps were viewed as innocuous lesions with no potential for progression to m

154 ependent increased sensitivity to a normally innocuous level of acetylcholine, which now also causes

155 llular signaling pathways, enabling normally innocuous levels of immune mediators to produce chronic

156 despread detection at such considerable (yet innocuous) levels suggested a considerable release.

157 sal horn that are important for transmitting innocuous light touch sensation.

158 Mechanical allodynia, induced by normally innocuous low-threshold mechanical stimulation, represen

159 tly raised the question of whether seemingly innocuous materials such as carbon-based nanotubes shoul

160 activation in the trigeminal ganglion during innocuous mechanical (brush) and noxious thermal (46 deg

161 racterized by their responses to noxious and innocuous mechanical facial stimulation.

162 2 channels are essential for transduction of innocuous mechanical forces by proprioceptors and cutane

163 t reduction in the threshold for escape from innocuous mechanical pressure (allodynia) and a reductio

164 injured animals exhibited novel responses to innocuous mechanical stimulation, and enhanced responses

165 Innocuous mechanical stimuli acting on the skin are dete

166 xamined neurons responded to noxious but not innocuous mechanical stimuli applied to their cutaneous

167 Finally, 8-pCPT sensitizes responses to innocuous mechanical stimuli without changing the electr

168 the skin and greatly heightened responses to innocuous mechanical stimuli.

169 To discern virulent from innocuous microbes, the innate immune system senses even

170 bout how animals discriminate pathogens from innocuous microbes.

171 -temporal signature of brain activity during innocuous, moderately more intense, and noxious stimulat

172 We first show that seemingly innocuous modifications to the task structure can induce

173 The more innocuous nature of long-wavelength light (>400nm) and i

174 Thus, the innocuous nature of SFV infection can be explained by re

175 tase catalyzes the conversion of toxic NO to innocuous nitrate.

176 ve the native ribonucleosides along with the innocuous nitrile side product.

177 noise, which damages hair cells, but not to innocuous noise, in neurons of the cochlear nucleus, but

178 Immune tolerance to both self-antigens and innocuous non-self-antigens is essential to protect the

179 piratory epithelial cells, converts normally innocuous NTHi OMP into potent inflammatory stimulants,

180 on interaction in negative mood states turns innocuous odors aversive, fueling anxiety and depression

181 -syn aggregates and induced the formation of innocuous oligomeric intermediates.

182 formatics analyses identified the relatively innocuous omega-3 fatty acid DHA (docosahexaenoic acid),

183 and pathogenic protein aggregates from more innocuous ones are poorly understood.

184 vity to mechanical stimuli that are normally innocuous or mildly painful (mechanical allodynia and hy

185 esia is characterized by hypersensitivity to innocuous or noxious stimuli during sustained opiate adm

186 17 thermally tested neurons, 16 responded to innocuous or noxious thermal stimuli.

187 lpha(+/lacZ) reporter mice expressing either innocuous or self-specific knocked in BCRs, beta-gal was

188 ticles, under DC potentials, when additional innocuous particles are used as fillers.

189 identified missense changes are likely to be innocuous passenger mutations or polymorphisms.

190 Distinguishing such "driver" mutations from innocuous "passenger" events is critical for prioritizin

191 under biologically relevant conditions with innocuous peptide byproducts.

192 emotional responses are evoked by seemingly innocuous perceptual stimuli.

193 autolysosomes where they are processed from innocuous precursors into neo-antimicrobial peptides, ex

194 This is not an innocuous problem.

195 TR) is used to catalyze the reduction of the innocuous prodrug metrodinazole (Mtz), thereby producing

196 This enzyme converts the innocuous prodrug metronidazole (MTZ) to a cytotoxin.

197 H(2)O(2) triggers in situ transformation of innocuous prodrugs into toxic parental drugs through cle

198 solvents and various other contaminants into innocuous products.

199 import and metabolism of e-fructoselysine to innocuous products.

200 posure to NO2, followed by inhalation of the innocuous protein Ag, OVA, would result in allergen sens

201 mate role of the environment in switching an innocuous protein into an amyloid-competent state, ratio

202 Mice sensitized to an innocuous protein using TLR ligands or house dust extrac

203 nd promote allergic sensitization to inhaled innocuous proteins in vivo.

204 n, including the transformation of initially innocuous proteins into oligomers and fibrils.

205 e based on producing a self-replicating, but innocuous PrP(Sc)-like form, termed anti-prion, which ca

206 In its native state, the prion protein is innocuous (PrPC), but it can misfold into a neurotoxic a

207 g fine details to distinguish V-weapons from innocuous pylons.

208 ublished a landmark paper asking a seemingly innocuous question: what can we extract about the outsid

209 Cold sensing in the innocuous range of cold (>10-15 degrees C) in the mammal

210 uggested to mediate cold transduction in the innocuous range.

211 Distinguishing pathogenic mutations from innocuous rare variants is critical to the interpretatio

212 he nanoconjugation cannot be construed as an innocuous reaction involved in attaching the targeting a

213 A catalytic Mitsunobu reaction using innocuous reagents to recycle these by-products would ov

214 onmental contaminants, i.e., PFCs, utilizing innocuous reagents, naturally occurring materials and mi

215 toward developing efficient strategies using innocuous reagents.

216 Moreover, immature B cells carrying an innocuous receptor have sustained elevation of PIP3 leve

217 In immature B cells carrying innocuous receptors, RAG expression appears to be under

218 ited by the lack of reliable methods for the innocuous recovery of surface captured cells.

219 ributed to the presence of large numbers of 'innocuous' resident bacteria that dilute or occupy niche

220 ew tetraphenylethene (TPE) conjugates via an innocuous route led to the revelation of a unique TPE-ba

221 tical roles in the processing of noxious and innocuous sensory information.

222 An innocuous sensory stimulus that reliably signals an upco

223 e away to avoid a threat when directed by an innocuous sensory stimulus.

224 Icilin increased both innocuous (sham-operated and SNL rats) and noxious (SNL

225 contrast, anticipation and extinction of the innocuous somatic stimulus failed to show that effect.

226 ry and secondary somatosensory cortices) and innocuous somatosensory perception (primary and secondar

227 ural and extracranial-cutaneous (noxious and innocuous) somatosensory stimulation, reflecting signatu

228 long-lasting, or repetitive short-duration, innocuous sounds.

229 were characterized by mechanical noxious and innocuous stimulation of the ipsilateral ophthalmic derm

230 learn to reduce their responses to repeated innocuous stimuli [1].

231 Following peripheral nerve injury, innocuous stimuli activated this nociceptive ensemble to

232 charge of VMM neurons changes in response to innocuous stimuli and during situations unrelated to noc

233 s, most noxious (painful) stimuli as well as innocuous stimuli are detected by spinal afferent neuron

234 s spontaneously and responses to noxious and innocuous stimuli are pathologically amplified.

235 itecture in which nociceptive, pruritic, and innocuous stimuli are processed by distinct molecularly

236 generalization of conditioned fear, in which innocuous stimuli elicit alarm.

237 populations that serve as a gate to prevent innocuous stimuli from activating the nociceptive and pr

238 w infants begin to discriminate noxious from innocuous stimuli is a fundamental question in neuroscie

239 uced nociceptive thresholds so that normally innocuous stimuli produce pain.

240 the mechanical hypersensitivity to normally innocuous stimuli that accompanies inflammation, nerve i

241 ransmission of noxious (painful) stimuli and innocuous stimuli that do not reach conscious sensations

242 tem needs to distinguish between harmful and innocuous stimuli to adapt its activation to the level o

243 ated by myelinated afferents that respond to innocuous stimuli, which suggests that injury-induced me

244 pain sensation to moderately noxious or even innocuous stimuli.

245 nia, a condition wherein pain is produced by innocuous stimuli.

246 tensity mechanical stimuli without affecting innocuous stimuli.

247 crises that occur in response to ordinarily innocuous stimuli.

248 by exaggerated pain in response to normally innocuous stimuli.

249 e can be switched to neutral by pairing with innocuous stimuli.

250 itized responses to both noxious or normally innocuous stimuli.

251 s of nociceptors so that they now respond to innocuous stimuli: the phenomenon of peripheral sensitiz

252 s, and allodynia, a pain-like response to an innocuous stimulus like touch.

253 Pavlovian conditioning results when an innocuous stimulus, such as an odour, is paired with a b

254 ay to avoid a threat signaled by a preceding innocuous stimulus.

255 imuli without affecting their response to an innocuous stimulus.

256 nt potentially toxic free fatty acids toward innocuous storage triglyceride in the liver.

257 o cross-reactivity with the other relatively innocuous strains studied.

258 ion of pathogens and minimize stimulation by innocuous substances and self-antigen.

259 allergens, which typically are intrinsically innocuous substances common in the environment, results

260 We mutated an innocuous surface residue to cysteine and labeled separa

261 hind paws to noxious heat (Hargreaves test), innocuous tactile (von Frey filaments), and cooling (ace

262 Mechanical allodynia, the perception of innocuous tactile stimulation as painful, is a severe sy

263 at primary afferent C-fibres that respond to innocuous tactile stimuli are important in the sensation

264 nvestigate how the aristal Cold Cells encode innocuous temperatures in Drosophila.

265 es C), low catalyst loadings (>=2 mol%), and innocuous terminal reductants (polymethylhydrosiloxane).

266 s and smaller populations of cells detecting innocuous thermal and light tactile stimuli.

267 uited to evaluate pain from pairs of noxious/innocuous thermal stimuli during different spatial atten

268 the central role of phasic thermosensing in innocuous thermosensation.

269 ive neurons can be divided into two classes: innocuous thermosensors (warm or cool) and noxious therm

270 us temperatures respond to hot or cold, many innocuous thermosensors exhibit robust baseline activity

271 that downregulate CES (e.g., OVSAHO) but are innocuous to a hepatocyte that overexpresses CES (HepG2)

272 ne, the unphosphorylated D-tetrapeptides are innocuous to all the cell lines, the mono- and diphospho

273 y neurons in a dose-dependent manner, but is innocuous to astrocytes, microglia, and oligodendrocytes

274 mtDNA) were once thought to be predominantly innocuous to cell growth.

275 oncentrations, the precursors themselves are innocuous to cells, but they double or triple the activi

276 Notably, while the l-peptide is relatively innocuous to cells, the d-peptide exerts a prolonged ant

277 shelf-life, conservation processes should be innocuous to consumers.

278 d that these proteins remain soluble and are innocuous to D. discoideum, in contrast to other organis

279 eumonia with an S. pneumoniae strain that is innocuous to mice in the absence of influenza infection.

280 heme in the metamorphosis of a bacteria from innocuous to pathogenic.

281 Although innocuous to some, common antigens can cause serious all

282 doses of risperidone and haloperidol may be innocuous to subsequent recovery after traumatic brain i

283 KO mice actively avoided a stimulus that was innocuous to wild-type controls, a sign of tactile defen

284 Together, these results suggest that innocuous touch and chemical itch information converge o

285 The first step leading to perception of innocuous touch is activation of cutaneous sensory neuro

286 NCE STATEMENT Mechanical allodynia, in which innocuous touch is perceived as pain, is a common featur

287 Innocuous touch of the skin is detected by distinct popu

288 in both humans and animal models, such that innocuous touch produces pain.

289 reshold mechanoreceptor subtypes involved in innocuous touch sensation.

290 to diverse stimuli, including the seemingly innocuous touch stimulus [1-4].

291 e spinal circuitry hard-wired for converting innocuous touch to irritating itch.

292 The nanoprobe shows an innocuous toxicity profile and sustained retention in tu

293 dings demonstrate that transient, ostensibly innocuous tumor subpopulations can promote metastases vi

294 In turn, these proteins, although innocuous under normal physiological conditions, enhance

295 mutations from similarly rare yet presumably innocuous variants.

296 ediate nor inevitable, as illustrated by the innocuous versus destructive infiltrates of BDC2.5 trans

297 model for the CD4(+) T cell response to an "innocuous" versus "dangerous" exogenous Ag and developed

298 ole for infection with reovirus, a seemingly innocuous virus, in triggering the development of CeD.

299 expressed in chemosensors, flies respond to innocuous warming with regurgitation, a nocifensive resp

300 TRPA1 responds to both noxious chemicals and innocuous warming, we find that TRPA1-expressing chemose