ライフサイエンスコーパス: inositol 1,4,5-trisphosphate

1 th an increase in the levels of its product, inositol 1,4,5-trisphosphate.

2 (PI(4,5)P(2) or PIP(2)) and the formation of inositol 1,4,5-trisphosphate.

3 nto the second messengers diacylglycerol and inositol 1,4,5-trisphosphate.

4 te also induces cytoplasmic concentration of inositol 1,4,5-trisphosphate.

5 of the second messengers, diacylglycerol and inositol-1,4,5-trisphosphate.

6 (2+)-releasing intracellular messenger d-myo-inositol 1,4,5-trisphosphate [1, Ins(1,4,5)P(3)] are imp

7 Inositol 1,4,5-trisphosphate 3-kinase A (IP3K-A) is a mo

8 In turn, inositol 1,4,5-trisphosphate 3-kinase B (Itpkb) phosphor

9 Inositol 1,4,5-trisphosphate 3-kinase B (or Itpkb) conve

10 iated proteins in human platelets identified inositol 1,4,5-trisphosphate 3-kinase isoform B (IP3KB)

11 We used inositol 1,4,5-trisphosphate accumulation and radioligan

12 Inositol 1,4,5-trisphosphate alone did not affect reacti

13 -grown 5ptase11 mutants contain increases in inositol (1,4,5) trisphosphate and an inositol bisphosph

14 hippocampal-dependent memory in part through inositol 1,4,5-trisphosphate and brain-derived neurotrop

15 Increases in inositol 1,4,5-trisphosphate and cytoplasmic Ca(2+) leve

16 y of cellular pathways through production of inositol 1,4,5-trisphosphate and diacylglycerol (DAG).

17 ts ability to generate the second messengers inositol 1,4,5-trisphosphate and diacylglycerol, PLC, un

18 ggers PLC-mediated hydrolysis of PIP(2) into inositol 1,4,5-trisphosphate and diacylglycerol, which a

19 ol 4,5-bisphosphate to the second messengers inositol 1,4,5-trisphosphate and diacylglycerol.

20 bsequent production of the second messengers inositol 1,4,5-trisphosphate and diacylglycerol.

21 eric G-protein coupling, and inhibits IP(3) (inositol-1,4,5-trisphosphate) and calcium mobilization,

22 hatidylinositol 4-phosphate, diacylglycerol, inositol 1,4,5-trisphosphate, and Ca(2+) upon muscarinic

23 ransient increases in intracellular calcium, inositol 1,4,5-trisphosphate, and G(q)-GTP in response t

24 (VSP), which depletes PIP2 without changing inositol 1,4,5-trisphosphate, and monitored NBCe1-mediat

25 , in particular via the second messenger myo-inositol 1,4,5-trisphosphate, and phosphoinositides comp

26 tensin II-induced cleavage is independent of inositol 1,4,5-trisphosphate- and Ca(2+)-mediated signal

27 but the downstream targets of Plc-generated inositol 1,4,5-trisphosphate are poorly described.

28 a receptor-independent method for producing inositol (1,4,5)-trisphosphate as the heart of the model

29 escent phosphatidylinositol 4,5-bisphosphate/inositol 1,4,5-trisphosphate biosensor GFP-PLCdelta1-PH

30 cted by inhibition of the production of IP3 (inositol-1,4,5-trisphosphate) by phospholipase-C and acc

31 mechanism involving M1/M3 receptor-mediated inositol 1,4,5-trisphosphate/Ca(+2) signalling and downs

32 mechanism involving M1/M3 receptor-mediated inositol 1,4,5-trisphosphate/Ca(+2) signalling and downs

33 large cholangiocytes by activation of D-myo-inositol 1,4,5-trisphosphate/Ca(2+) /calmodulin-dependen

34 inhibit NBCe1, whereas hydrolysis of PIP2 to inositol 1,4,5-trisphosphate/Ca(2+) can stimulate the tr

35 nd -C in the intact oocyte primarily through inositol 1,4,5-trisphosphate/Ca(2+).

36 luble inositol phosphate headgroups, such as inositol 1,4,5-trisphosphate, can compete with PtdIns(4,

37 Instead, S1PR2 stimulated inositol 1,4,5-trisphosphate-dependent Ca(++) release an

38 ia L-type Ca(2+) channels and, on the other, inositol 1,4,5-trisphosphate-dependent Ca(2+) release.

39 increasing ROS production which facilitated inositol 1,4,5-trisphosphate-dependent Ca(2+) release.

40 inic acid-adenine dinucleotide phosphate- or inositol 1,4,5-trisphosphate-dependent calcium release a

41 R expression, (iii) persistent activation of inositol 1,4,5-trisphosphate-dependent cell signaling ca

42 idylinositol 4,5-bisphosphate hydrolysis and inositol 1,4,5-trisphosphate-dependent intra-acrosomal c

43 These data reveal the existence of an inositol 1,4,5-trisphosphate-dependent nuclear Ca(2+) to

44 Stimulation of endothelial inositol 1,4,5-trisphosphate-dependent signaling with su

45 )), which we show is mediated by SHP-2 in an inositol-1,4,5-trisphosphate-dependent manner.

46 ng concentrations for intracellular calcium, inositol 1,4,5-trisphosphate, diacylglycerol, phosphatid

47 Inositol 1,4,5-trisphosphate-generating agonist evoked c

48 signaling under these conditions depends on inositol-1,4,5-trisphosphate generation from phospholipa

49 onse to environmental cues that promote IP3 (inositol 1,4,5-trisphosphate) generation, IP3 receptors

50 l 4,5-bisphosphate (PIP(2)) and formation of inositol 1,4,5-trisphosphate in TRPV6-expressing cells.

51 ease from the sarcoplasmic reticulum through inositol 1,4,5-trisphosphate-induced Ca release and not

52 as inhibited by blocking phospholipase C and inositol 1,4,5-trisphosphate-induced Ca(2+) release, ind

53 We investigated synergism between inositol 1,4,5-trisphosphate (Ins(1,4,5)P(3)) and diacyl

54 belongs to a family of kinases that convert inositol 1,4,5-trisphosphate (Ins(1,4,5)P3 or IP3) to in

55 We investigated the contribution of inositol(1,4,5)-trisphosphate (Ins(1,4,5)P3 [IP3]) recep

56 butes to intracellular signaling through its inositol-1,4,5-trisphosphate (Ins(1,4,5)P3) 3-kinase and

57 2+)-mobilizing intracellular messenger d-myo-inositol 1,4,5-trisphosphate [Ins(1,4,5)P(3)].

58 4,5)P(2) levels was accompanied by increased inositol 1,4,5 trisphosphate (InsP(3)) production, and w

59 s also were reduced by selectively buffering inositol 1,4,5-trisphosphate (InsP(3)) within the nucleu

60 asticity (ITDP) in cortical input depends on inositol 1,4,5-trisphosphate (InsP(3))-sensitive Ca(2+)

61 The phosphoinositide pathway and inositol-1,4,5-trisphosphate (InsP(3)) are implicated in

62 ss that is regulated, in mammalian cells, by inositol-1,4,5-trisphosphate (InsP(3)), cyclic ADP ribos

63 ough metabolism of phytate and production of inositol-1,4,5-trisphosphate (InsP(3)).

64 to the nucleus, as well as upon formation of inositol 1,4,5,-trisphosphate (InsP3) in the nucleus, wh

65 tal opening; [Ca(2+) ](cyt) oscillation; and inositol 1,4,5-trisphosphate (InsP3) production.

66 nd -C in the intact oocyte primarily through inositol 1,4,5-trisphosphate (InsP3)/Ca(2+).

67 2+) release and airway contraction evoked by inositol-1,4,5-trisphosphate (InsP3) uncaging in airway

68 For Ca2+ signals initiated by inositol-1,4,5-trisphosphate (InsP3), this requires loca

69 Inositol 1, 4, 5-trisphosphate (IP(3)) binding at the N-

70 crystallographic studies have emphasized PH-inositol 1,4,5-trisphosphate (IP 3) interactions, biophy

71 We propose that inositol 1,4,5-trisphosphate (IP(3) )-dependent Ca(2+) s

72 hatidylinositol 4,5-bisphosphate (PIP(2)) to inositol 1,4,5-trisphosphate (IP(3)) and diacylglycerol

73 y results from an increase in the potency of inositol 1,4,5-trisphosphate (IP(3)) in producing facili

74 Inositol 1,4,5-trisphosphate (IP(3)) is a crucial second

75 Inositol 1,4,5-trisphosphate (IP(3)) is a second messeng

76 eration, and Inpp5a overexpression decreases inositol 1,4,5-trisphosphate (IP(3)) levels and ameliora

77 gamma2 (PLCgamma2) accounts for LPS-induced inositol 1,4,5-trisphosphate (IP(3)) production and subs

78 +)](i)) by increasing the sensitivity of the inositol 1,4,5-trisphosphate (IP(3)) receptor (IP(3)R) t

79 ivation of TRPC3 channels is concurrent with inositol 1,4,5-trisphosphate (IP(3)) receptor (IP(3)R)-m

80 The inositol 1,4,5-trisphosphate (IP(3)) receptor is a Ca(2+

81 e that mir-240/786 functions upstream of the inositol 1,4,5-trisphosphate (IP(3)) receptor.

82 The inositol 1,4,5-trisphosphate (IP(3)) receptors (IP(3)Rs)

83 Inositol 1,4,5-trisphosphate (IP(3)) receptors (IP(3)Rs)

84 Inositol 1,4,5-trisphosphate (IP(3)) receptors are endop

85 Inositol 1,4,5-trisphosphate (IP(3)) receptors form tetr

86 In pancreatic acinar cells, inositol 1,4,5-trisphosphate (IP(3)) receptors populate

87 led receptors (GPCRs) through the binding of inositol 1,4,5-trisphosphate (IP(3)) to its receptor (IP

88 ssay in which binding of fluorescein-labeled inositol 1,4,5-trisphosphate (IP(3)) to N-terminal fragm

89 Physiologically, the production of inositol 1,4,5-trisphosphate (IP(3)) upon stimulation of

90 , which encompasses dramatic potentiation of inositol 1,4,5-trisphosphate (IP(3))-dependent Ca(2+) re

91 icoids inhibit downstream responses, such as inositol 1,4,5-trisphosphate (IP(3))-induced calcium sig

92 Inositol 1,4,5-trisphosphate (IP(3))-induced vasoconstri

93 Although inositol 1,4,5-trisphosphate (IP(3))-mediated Ca(2+) rel

94 d knockout mice, we show that in addition to inositol 1,4,5-trisphosphate (IP(3))-mediated Ca(2+) rel

95 osolic Ca(2+) rise is primarily initiated by inositol 1,4,5-trisphosphate (IP(3))-mediated Ca(2+) rel

96 lations are initiated by Ca(2+) release from inositol 1,4,5-trisphosphate (IP(3))-sensitive intracell

97 (VGCC) and mobilization of Ca(2+) from both inositol 1,4,5-trisphosphate (IP(3))-sensitive stores an

98 h promotes the release of diacylglycerol and inositol 1,4,5-trisphosphate (IP(3)).

99 d trigger production of the second messenger inositol 1,4,5-trisphosphate (IP(3)).

100 it does not have a significant affinity for inositol 1,4,5-trisphosphate (IP(3)).

101 otein, adenylyl cyclase, Epac-1 protein, and inositol 1,4,5-trisphosphate (IP(3))/IP(3) receptor, wer

102 efficient chemical synthesis of an analog of inositol-1,4,5-trisphosphate (IP(3)) hexakis acetoxymeth

103 d by silencing of the NBCe1-B/CFTR activator inositol-1,4,5-trisphosphate (IP(3)) receptor-binding pr

104 We studied inositol-1,4,5-trisphosphate (IP(3)) receptor-dependent

105 to phospholipase C-coupled receptors elevate inositol-1,4,5-trisphosphate (IP(3)).

106 Hormone-induced inositol 1,4,5 trisphosphate (IP3 ) accumulation and pho

107 thway occurs at the level of hormone-induced inositol 1,4,5 trisphosphate (IP3 ) production and does

108 hate (IP), inositol 4,5-bisphosphate (IP2 ), inositol 1,4,5-trisphosphate (IP3 ), and inositol hexaki

109 on is an increase in [Ca(2+) ]i triggered by inositol 1,4,5-trisphosphate (IP3 )-induced release of C

110 d CaMKII activation is probably initiated by inositol 1,4,5-trisphosphate (IP3 )-mobilized Ca(2+) : 8

111 ly to involve downstream Ca(2+) release from inositol 1,4,5-trisphosphate (IP3 )-triggered Ca(2+) -st

112 (PLC-gamma1), with the resultant increase in inositol 1,4,5-trisphosphate (IP3) and intracellular cal

113 on, nuclear mGlu5 receptors generate nuclear inositol 1,4,5-trisphosphate (IP3) in situ.

114 ausing mutant presenilins (PS) interact with inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) Ca(2+

115 anisms, e.g., single channel kinetics of the inositol 1,4,5-trisphosphate (IP3) receptor Ca2+ channel

116 omain mediates interaction of Bcl-2 with the inositol 1,4,5-trisphosphate (IP3) receptor, an IP3-gate

117 ertebrate genomes code for three subtypes of inositol 1,4,5-trisphosphate (IP3) receptors (IP3R1, -2,

118 nic M3 receptors, or by direct activation of inositol 1,4,5-trisphosphate (IP3) receptors by photolys

119 ntributes to the ubiquitination of activated inositol 1,4,5-trisphosphate (IP3) receptors, and also,

120 hosphate kinase 2 (ip3k2), thereby affecting inositol 1,4,5-trisphosphate (IP3) signaling and calcium

121 holipase C-gamma (PLC-gamma) which increases inositol 1,4,5-trisphosphate (IP3) to release intracellu

122 T-cell activation releases inositol 1,4,5-trisphosphate (IP3), inducing cytoplasmic

123 Genetically blocking inositol 1,4,5-trisphosphate (IP3)-dependent Ca(2+) incr

124 Sigma-1 receptor (sigma-1R) agonists enhance inositol 1,4,5-trisphosphate (IP3)-dependent calcium rel

125 opic glutamate receptors (mGluRs) generating inositol 1,4,5-trisphosphate (IP3).

126 ition of the phospholipase C gamma 2 (PLCG2)/inositol 1,4,5-trisphosphate (IP3)/Ca(2+)/protein kinase

127 In addition, we identified the type 1 inositol-1,4,5-trisphosphate (IP3) receptor (ITPR1), an

128 Here we show that the cerebellar inositol-1,4,5-trisphosphate (IP3) receptor, whose activ

129 the cell and parallel fiber stimulus evoking inositol-1,4,5-trisphosphate (IP3)-meditated calcium rel

130 Here we report that the protein IRBIT (inositol-1,4,5-trisphosphate [IP3] receptors binding pro

131 ntext-specific autophagy through its target, inositol 1,4,5-trisphosphate kinase 2 (ip3k2), thereby a

132 C and to the formation of diacylglycerol and inositol 1,4,5-trisphosphate, leading to the release of

133 celerating Ca(2+) clearance and exaggerating inositol 1,4,5-trisphosphate-mediated Ca(2+) liberation.

134 rial function and to involve phospholipase C/inositol 1,4,5-trisphosphate-mediated Ca(2+) mobilizatio

135 steoclast (OC) differentiation by modulating inositol 1,4,5-trisphosphate-mediated calcium oscillatio

136 slocates to the nucleus to initiate nuclear, inositol 1,4,5-trisphosphate-mediated calcium signals in

137 lus secretion coupling and its regulation by inositol 1,4,5-trisphosphate, nicotinic acid adenine din

138 or the first time that the POCKET containing inositol 1,4,5-trisphosphate on crystal structure (the "

139 ce of extracellular Ca(2+), and that the PLC-inositol 1,4,5-trisphosphate pathway, which controls the

140 egranulation by thapsigargin, which bypasses inositol 1,4,5-trisphosphate production, is also substan

141 ysis of phosphatidylinositol 4,5-biphosphate inositol 1,4,5-trisphosphate production, nuclear Ca(2+)

142 PLCgamma1 phosphorylation and inhibition of inositol 1,4,5-trisphosphate production.

143 phospholipase C beta2 and the stimulation of inositol 1,4,5-trisphosphate production.

144 ome through phospholipase C, which catalyses inositol-1,4,5-trisphosphate production and thereby indu

145 discovered that mHtt protein binds to type 1 inositol (1,4,5)-trisphosphate receptor (InsP3R1) and in

146 Functional coupling between inositol (1,4,5)-trisphosphate receptor (IP(3)R) and rya

147 Inositol 1, 4, 5-trisphosphate receptor (IP3R)-mediated

148 The inositol 1,4,5 trisphosphate receptor (IP3R) is an intra

149 The potentiation is absent in conditional inositol 1,4,5 trisphosphate receptor type 2 KO mice, wh

150 tin A (AdA) is a potent agonist of the d-myo-inositol 1,4,5-trisphosphate receptor (Ins(1,4,5)P3R).

151 ut not wild-type Atx2 specifically binds the inositol 1,4,5-trisphosphate receptor (InsP(3)R) and inc

152 (i)) by endoplasmic reticulum (ER)-localized inositol 1,4,5-trisphosphate receptor (InsP(3)R) Ca(2+)-

153 The inositol 1,4,5-trisphosphate receptor (InsP(3)R), an int

154 o binds to and amplifies the activity of the inositol 1,4,5-trisphosphate receptor (InsP(3)R).

155 protein that modulates Ca(2+) release by the inositol 1,4,5-trisphosphate receptor (InsP(3)R).

156 The type 1 inositol 1,4,5-trisphosphate receptor (InsP(3)R1) is a u

157 th the cytosolic C-terminal region of type 1 inositol 1,4,5-trisphosphate receptor (InsP(3)R1), an in

158 ) specifically binds to and activates type 1 inositol 1,4,5-trisphosphate receptor (InsP(3)R1), an in

159 exp) specifically associated with the type 1 inositol 1,4,5-trisphosphate receptor (InsP(3)R1), an in

160 -mediated calcium release through the type 2 inositol 1,4,5-trisphosphate receptor (InsP(3)R2) in car

161 Bcl-2 interacts with the inositol 1,4,5-trisphosphate receptor (InsP3R) and thus

162 PS1 (M146L)and PS2 (N141I) interact with the inositol 1,4,5-trisphosphate receptor (InsP3R) Ca2+ rele

163 2+ release from intracellular stores through inositol 1,4,5-trisphosphate receptor (InsP3R) channels

164 , neuronal calcium sensor 1 (NCS-1), and the inositol 1,4,5-trisphosphate receptor (InsP3R) to preven

165 er intracellular Ca(2+) channels such as the inositol 1,4,5-trisphosphate receptor (InsP3R), is neces

166 known to increase the activity of the type-1 inositol 1,4,5-trisphosphate receptor (InsP3R1).

167 alicular membrane is mediated by the type II inositol 1,4,5-trisphosphate receptor (InsP3R2), so we i

168 mutation in ITPR2, which encodes the type 2 inositol 1,4,5-trisphosphate receptor (InsP3R2), that wa

169 The type III isoform of the inositol 1,4,5-trisphosphate receptor (InsP3R3) is apica

170 lobal Ca(2+) concentration ([Ca(2+)](i)) via inositol 1,4,5-trisphosphate receptor (IP(3)R) activatio

171 poptotic activity of Bcl-2 by binding to the inositol 1,4,5-trisphosphate receptor (IP(3)R) Ca(2)(+)

172 in the channel domain that are critical for inositol 1,4,5-trisphosphate receptor (IP(3)R) channel f

173 t gating dynamics of a single, nonconducting inositol 1,4,5-trisphosphate receptor (IP(3)R) channel,

174 examethasone induces a striking elevation of inositol 1,4,5-trisphosphate receptor (IP(3)R) levels in

175 euronal Ca(2+) signaling by enhancing type-1 inositol 1,4,5-trisphosphate receptor (IP(3)R) steady-st

176 we demonstrated that PC2 interacts with the inositol 1,4,5-trisphosphate receptor (IP(3)R) to modula

177 ng a proteomics approach, we identify type 1 inositol 1,4,5-trisphosphate receptor (IP(3)R1) as a spe

178 During oocyte maturation, the inositol 1,4,5-trisphosphate receptor (IP(3)R1), the cha

179 is and the degradation of the Ca(2+) channel inositol 1,4,5-trisphosphate receptor (IP3R) affects pro

180 Inositol 1,4,5-trisphosphate receptor (IP3R) antagonists

181 Furthermore, inositol 1,4,5-trisphosphate receptor (IP3R) but not rya

182 sm involves an interaction of Bcl-2 with the inositol 1,4,5-trisphosphate receptor (IP3R) Ca2+ channe

183 A canonical example is the inositol 1,4,5-trisphosphate receptor (IP3R) channel, wh

184 The inositol 1,4,5-trisphosphate receptor (IP3R) is a ubiqui

185 r ryanodine (400 microM), the antagonists of inositol 1,4,5-trisphosphate receptor (IP3R) or ryanodin

186 om apical Ca(2+) pools that are gated by the inositol 1,4,5-trisphosphate receptor (IP3R) types 2 and

187 n genes encoding the neuronal isoform of the inositol 1,4,5-trisphosphate receptor (ITPR1) and genes

188 ffects of NAFLD on expression of the type II inositol 1,4,5-trisphosphate receptor (ITPR2), the princ

189 The type 3 isoform of the inositol 1,4,5-trisphosphate receptor (ITPR3) is the mos

190 The type 3 inositol 1,4,5-trisphosphate receptor (ITPR3) is the pri

191 rypanosoma brucei acidocalcisomes possess an inositol 1,4,5-trisphosphate receptor (TbIP(3)R) for Ca(

192 sed from these organelles through a channel, inositol 1,4,5-trisphosphate receptor (TbIP(3)R), which

193 sed phosphorylation of the ER Ca(2+) channel inositol 1,4,5-trisphosphate receptor 1 (IP3R1) in CNG c

194 , voltage-dependent Ca(2+) channels, and the inositol 1,4,5-trisphosphate receptor as well as the N-m

195 ch is blunted by internal store depletion or inositol 1,4,5-trisphosphate receptor blockade.

196 parks arise from the cooperative activity of inositol 1,4,5-trisphosphate receptor Ca(2+) channels (I

197 co/ER Ca(2+) ATPase, ryanodine receptor, and inositol 1,4,5-trisphosphate receptor channel in various

198 tributed to the differential distribution of inositol 1,4,5-trisphosphate receptor channel isoforms i

199 R Ca(2+) ATPase, ER Ca(2+) release channels, inositol 1,4,5-trisphosphate receptor channel, ryanodine

200 ized releases of calcium through clusters of inositol 1,4,5-trisphosphate receptor channels constitut

201 phate receptor (ITPR1) and genes involved in inositol 1,4,5-trisphosphate receptor degradation (ERLIN

202 phospholipase C inhibitor U73122 and by the inositol 1,4,5-trisphosphate receptor inhibitor Xestospo

203 athway in which the expression of the type-1 inositol 1,4,5-trisphosphate receptor is regulated by th

204 Inositol 1,4,5-trisphosphate receptor isoforms are a fam

205 g gate structure is conserved in all RyR and inositol 1,4,5-trisphosphate receptor isoforms.

206 An increase in type-1 inositol 1,4,5-trisphosphate receptor mRNA and protein s

207 vation of cytosolic Ca(2+) by binding to the inositol 1,4,5-trisphosphate receptor on the endoplasmic

208 monitor conformational changes of the type I inositol 1,4,5-trisphosphate receptor protein in membran

209 ubiquitinated endoplasmic reticulum protein inositol 1,4,5-trisphosphate receptor type 1 (IP3R1), wh

210 563del] and c.7659T>G [p.Phe2553Leu]) in the inositol 1,4,5-trisphosphate receptor type 1 gene (ITPR1

211 TPase and ryanodine receptor type 2, but not inositol 1,4,5-trisphosphate receptor type 2, were requi

212 mitochondrial calcium uniporter) and TcIP3R (inositol 1,4,5-trisphosphate receptor).

213 d upon activation of phospholipase C and the inositol 1,4,5-trisphosphate receptor, but not upon extr

214 Moreover, direct PC2 binding to inositol 1,4,5-trisphosphate receptor, KIF3A, and TRPC1

215 n immunoprecipitation assay, we found ITPR1 (inositol 1,4,5-trisphosphate receptor, type 1) as a dire

216 A variant (rs718314) in the inositol 1,4,5-trisphosphate receptor, type 2 gene (ITPR

217 espective primary tumors, include C17orf104, inositol 1,4,5-trisphosphate receptor, type 3 (ITPR3), a

218 tically, we showed that HAX-1 interacts with inositol 1,4,5-trisphosphate receptor-1 (InsP3R1) in the

219 Hg, ECs generated low-frequency (~2 min(-1)) inositol 1,4,5-trisphosphate receptor-based Ca(2+) event

220 onapoptotic necrotic cell death triggered by inositol 1,4,5-trisphosphate receptor-dependent calcium

221 l melastatin subfamily 4 channels via type 2 inositol 1,4,5-trisphosphate receptor-mediated Ca(2+) re

222 Additionally, inositol 1,4,5-trisphosphate receptor-mediated release o

223 ive to inhibitors of the phospholipase C and inositol 1,4,5-trisphosphate receptor.

224 They arise from clustered inositol 1,4,5-trisphosphate receptor/channels (IP3Rs),

225 inds, deubiquitylates, and stabilizes type 3 inositol-1,4,5-trisphosphate receptor (IP3R3), modulatin

226 ed morphology and express IP3R3, which is an inositol-1,4,5-trisphosphate receptor constitutively exp

227 transients (CaTs) are due to upregulation of inositol-1,4,5-trisphosphate receptor induced Ca(2+) rel

228 Calcium release through inositol (1,4,5)-trisphosphate receptors (InsP(3)R) is t

229 ATP enhances Ca(2+) release from inositol (1,4,5)-trisphosphate receptors (InsP(3)R).

230 to demonstrate that sensitization of type 1 inositol (1,4,5)-trisphosphate receptors by mHtt, which

231 lting in reduced disulfide bond formation in inositol 1, 4, 5-trisphosphate receptors (IP3Rs).

232 Phosphorylation of inositol 1,4,5-trisphosphate receptors (InsP(3)R) by PKA

233 Ca(2+) release through inositol 1,4,5-trisphosphate receptors (InsP(3)R) can be

234 Protein kinase A (PKA) phosphorylation of inositol 1,4,5-trisphosphate receptors (InsP(3)Rs) repre

235 ositive and negative [Ca(2+)](i) feedback on inositol 1,4,5-trisphosphate receptors (InsP(3)Rs).

236 Inositol 1,4,5-trisphosphate receptors (InsP3Rs) are end

237 regulates several Ca(2+) channels, including inositol 1,4,5-trisphosphate receptors (InsP3Rs).

238 family, modulates Ca2+-dependent activity of inositol 1,4,5-trisphosphate receptors (InsP3Rs).

239 Others, including the almost ubiquitous inositol 1,4,5-trisphosphate receptors (IP(3)R) and thei

240 stimulates formation of cAMP and sensitizes inositol 1,4,5-trisphosphate receptors (IP(3)R) to IP(3)

241 in A (AdA), the most potent agonist of d-myo-inositol 1,4,5-trisphosphate receptors (IP(3)R), is thou

242 upling of sarcoplasmic reticulum (SR) type 1 inositol 1,4,5-trisphosphate receptors (IP(3)R1) to plas

243 es of endoplasmic reticulum Ca(2+) channels, inositol 1,4,5-trisphosphate receptors (IP(3)Rs) and rya

244 Inositol 1,4,5-trisphosphate receptors (IP(3)Rs) form te

245 A number of studies have demonstrated that inositol 1,4,5-trisphosphate receptors (IP(3)Rs) interac

246 Calcium (Ca(2+)) release through inositol 1,4,5-trisphosphate receptors (IP(3)Rs) regulat

247 knockdown and pharmacological inhibition of inositol 1,4,5-trisphosphate receptors (IP(3)Rs) stimula

248 pled receptors stimulates Ca(2+) release via inositol 1,4,5-trisphosphate receptors (IP(3)Rs), engagi

249 etabotropic glutamate receptors (mGluRs) and inositol 1,4,5-trisphosphate receptors (IP(3)Rs), suppor

250 ted by intracellular calcium release through inositol 1,4,5-trisphosphate receptors (IP(3)Rs).

251 ) release through the ryanodine receptors or inositol 1,4,5-trisphosphate receptors (IP3 R) and upon

252 Inositol 1,4,5-trisphosphate receptors (IP3 Rs) are a fa

253 Ryanodine receptors (RyRs) and inositol 1,4,5-trisphosphate receptors (IP3 Rs) are calc

254 Inositol 1,4,5-trisphosphate receptors (IP3 Rs) are expr

255 The ability of inositol 1,4,5-trisphosphate receptors (IP3R) to precise

256 ype 2 ryanodine receptors (RyR2s) and type 2 inositol 1,4,5-trisphosphate receptors (IP3R2s).

257 ms, like the endoplasmic reticulum-localized inositol 1,4,5-trisphosphate receptors (IP3Rs) and the v

258 Little is known about the function of inositol 1,4,5-trisphosphate receptors (IP3Rs) in the ad

259 hat Bok binds strongly and constitutively to inositol 1,4,5-trisphosphate receptors (IP3Rs), proteins

260 cell lines that Bok interacts strongly with inositol 1,4,5-trisphosphate receptors (IP3Rs), suggesti

261 Such release occurs through a cluster of inositol 1,4,5-trisphosphate receptors (IP3Rs).

262 otic cell death require calcium release from inositol 1,4,5-trisphosphate receptors (IP3Rs).

263 ly dependent on Ca2+ oscillation mediated by inositol 1,4,5-trisphosphate receptors 2 and 3 (ITPR2 an

264 ) release from the endoplasmic reticulum via inositol 1,4,5-trisphosphate receptors and by Ca(2+) ent

265 the cooperative activity of Ca(2+)-regulated inositol 1,4,5-trisphosphate receptors and ryanodine rec

266 uggests that it results from potentiation of inositol 1,4,5-trisphosphate receptors and/or phospholip

267 Activated inositol 1,4,5-trisphosphate receptors are then rapidly

268 epletion of internal stores or inhibition of inositol 1,4,5-trisphosphate receptors but not by inhibi

269 2+) signals interact with both ryanodine and inositol 1,4,5-trisphosphate receptors during agonist st

270 iquitin E3 ligase gene RNF170, which targets inositol 1,4,5-trisphosphate receptors for degradation,

271 nd blockade of either ryanodine receptors or inositol 1,4,5-trisphosphate receptors reduced [Ca(2+)](

272 astrocytes lack mGluR5, and knockout of the inositol 1,4,5-trisphosphate receptors that release Ca(2

273 neurons, cGKII-dependent phosphorylation of inositol 1,4,5-trisphosphate receptors was decreased, re

274 activity were also blunted by inhibition of inositol 1,4,5-trisphosphate receptors with 2-aminoethox

275 reticulum membrane (ryanodine receptors and inositol 1,4,5-trisphosphate receptors) of isolated card

276 and endoplasmic reticulum Ca(2+) release via inositol 1,4,5-trisphosphate receptors.

277 release from the nucleoplasmic reticulum by inositol 1,4,5-trisphosphate receptors.

278 through the PKA-mediated phosphorylation of inositol-1,4,5-trisphosphate receptors (InsP(3)Rs), whic

279 Inositol-1,4,5-trisphosphate receptors (InsP3Rs) are ubi

280 d the detailed intracellular distribution of inositol-1,4,5-trisphosphate receptors (IP(3)Rs), and ry

281 s (RyRs), dihydropyridine receptors (DHPRs), inositol-1,4,5-trisphosphate receptors (IP(3)Rs), canoni

282 Inositol-1,4,5-trisphosphate receptors (IP3 Rs) modulate

283 IRE1alpha determined the distribution of inositol-1,4,5-trisphosphate receptors at MAMs by operat

284 ryanodine receptors, increased expression of inositol-1,4,5-trisphosphate receptors, and differential

285 gated Ca(2+) channels, the ryanodine and the inositol-1,4,5-trisphosphate receptors.

286 IP(3) (inositol 1,4,5-trisphosphate) receptors (IP(3)Rs) regula

287 naptic stores (activated by spot-uncaging of inositol 1,4,5-trisphosphate) remain unaffected by GPR55

288 he lack of coupling between SP signaling and inositol 1,4,5-trisphosphate sensitive Ca(2+) stores, to

289 holipase C but is largely uncoupled from the inositol 1,4,5-trisphosphate sensitive Ca(2+) stores.

290 arise from regenerative Ca(2+) release from inositol 1,4,5-trisphosphate-sensitive stores followed b

291 Our findings highlight inositol 1,4,5-trisphosphate signaling as a candidate ke

292 Moreover, endogenous inositol-1,4,5-trisphosphate stimulation by the phosphol

293 trisphosphate 3-kinase B (or Itpkb) converts inositol 1,4,5-trisphosphate to inositol 1,3,4,5-tetraki

294 IPMK phosphorylates inositol 1,4,5-trisphosphate to inositol tetrakisphospha

295 to the cytoplasm is controlled by binding of inositol 1,4,5-trisphosphate to its receptor.

296 vely, these results support the concept that inositol-1,4,5-trisphosphate type 3 receptor signaling i

297 ulation of abscisic acid (ABA), proline, and inositol 1,4,5-trisphosphate under osmotic stress.

298 variety of inositol phosphates including myo-inositol 1,4,5-trisphosphate, which is a secondary messe

299 se C and the formation of diacylglycerol and inositol 1,4,5-trisphosphate, which results in the relea

300 ) to produce cAMP and via G(q/11) to produce inositol-1,4,5-trisphosphate, which is degraded to inosi