ライフサイエンスコーパス: inositol hexakisphosphate

1 cPho5, is not able to hydrolyze phytic acid (inositol hexakisphosphate).

2 biomolecules of low molecular weight (e.g., inositol hexakisphosphates).

3 t metabolites inositol pentakisphosphate and inositol hexakisphosphate.

4 that measured the displacement of D-myo-[3H]inositol hexakisphosphate.

5 on heparin-agarose and affinity elution with inositol hexakisphosphate.

6 fy specific NMR signals like myo- and scyllo-inositol hexakisphosphate.

7 tion identified the bioactive molecule as an inositol hexakisphosphate.

8 ty is stimulated by Gle1 and its coactivator inositol hexakisphosphate.

9 akisphosphate 2-kinase (Ipk1) that generates inositol hexakisphosphate.

10 Inositol hexakisphosphate-1 (IP6K1) generates the inosit

11 rmore, available structures for inactive and inositol hexakisphosphate 6-activated forms of bovine be

12 Inositol hexakisphosphate accounted for 46-54% of the so

13 Inositol hexakisphosphate and other inositol high polyph

14 AP3 binds both inositol hexakisphosphate and preassembled clathrin cage

15 finity (Km = 0.7 microM) and selectivity for inositol hexakisphosphate as substrate.

16 roles for stress-induced phosphorylation and inositol hexakisphosphate binding in specifying Gle1 fun

17 However, neither inositol hexakisphosphate binding nor clathrin cage bind

18 Inositol hexakisphosphate, but not inositol tetrakisphos

19 repeat domain of TIR1 contains an unexpected inositol hexakisphosphate co-factor and recognizes auxin

20 However, with the addition of inositol hexakisphosphate, Gag adopts a linear conformat

21 ltiplexing a metabolic pathway to synthesize inositol hexakisphosphate (ie InsP(6) or phytate), throu

22 tended conformation required the presence of inositol hexakisphosphate in addition to nucleic acid.

23 was only 7.5-fold weaker a ligand than D-myo-inositol hexakisphosphate in assays that measured the di

24 approach, we identified a critical role for inositol hexakisphosphate in pentamer formation and dete

25 Both [3H]inositol trisphosphate and [3H]inositol hexakisphosphate increased 3-and 1.5-fold, resp

26 upted, although the presence of 10% residual inositol hexakisphosphate indicates the existence of a m

27 cellular interactions between arrestin-2 and inositol hexakisphosphate (inositol 1,2,3,4,5,6-hexakisp

28 al toxin TcdB and recent studies showed that inositol hexakisphosphate (Ins(1,2,3,4,5,6)P(6) or InsP(

29 proteolytically processed in the presence of inositol hexakisphosphate (InsP(6)) by an intrinsic cyst

30 ophila pathways leading to the production of inositol hexakisphosphate (InsP(6)) have been elucidated

31 enzyme(s) responsible for the production of inositol hexakisphosphate (InsP(6)) in vertebrate cells

32 Inositol hexakisphosphate (InsP(6)) levels rise and fall

33 ol 1,3,4,5,6-pentakisphosphate (InsP(5)) and inositol hexakisphosphate (InsP(6)) levels were depleted

34 mammals (types 1 and 2), which phosphorylate inositol hexakisphosphate (InsP(6)) to diphosphoinositol

35 ol 1,3,4,5,6-pentakisphosphate (InsP(5)) and inositol hexakisphosphate (InsP(6)) with high affinity i

36 * Myo-inositol hexakisphosphate (InsP(6)), abundant in animals

37 ere by Gle1 together with the small-molecule inositol hexakisphosphate (InsP(6)).

38 which is promoted by the allosteric cofactor inositol hexakisphosphate (InsP(6)).

39 The CPD is activated upon binding inositol hexakisphosphate (InsP(6)).

40 roduce large amounts of their precursor, myo-inositol hexakisphosphate (InsP6 ).

41 Interestingly, Gle1 binds directly to inositol hexakisphosphate (InsP6) and InsP6 potentiates

42 myces cerevisiae defined an in vivo role for inositol hexakisphosphate (InsP6) and NPC-associated Gle

43 InsP7 is formed from inositol hexakisphosphate (InsP6) by a family of three i

44 InsP7 is formed from inositol hexakisphosphate (InsP6) by recently identified

45 Cellular inositol hexakisphosphate (InsP6) induces an autocatalyt

46 Recent studies have shown inositol hexakisphosphate (InsP6) is a potent cofactor f

47 myo-Inositol hexakisphosphate (InsP6) is the most abundant i

48 Surprisingly, an inositol hexakisphosphate (InsP6) molecule binds to a pr

49 akisphosphate kinases (InsP6Ks) that convert inositol hexakisphosphate (InsP6) to InsP7, conferred en

50 ted by the eukaryote-specific small molecule inositol hexakisphosphate (InsP6), and we present the 2.

51 After activation by inositol hexakisphosphate (InsP6), the autoprotease clea

52 r InsP6 kinase (InsP6K/IP6K), which converts inositol hexakisphosphate (InsP6/IP6) to InsP7, causes r

53 Eukaryotic inositol-hexakisphosphate (InsP6) binds an autoprocessin

54 Phytic acid (myo-inositol hexakisphosphate, InsP6) is an important phosph

55 uring messenger (m)RNA export, Gle1 bound to inositol hexakisphosphate (IP(6)) acts via Dbp5 to facil

56 rapamycin (mTOR) binds the small metabolite inositol hexakisphosphate (IP(6)) as shown in structures

57 The cellular polyanion inositol hexakisphosphate (IP(6)) binds to a positively

58 solution, revealing stable association of an inositol hexakisphosphate (IP(6)) molecule.

59 Four stereoisomers of inositol hexakisphosphate (IP(6)) occur, although for th

60 , the conserved mRNA export factors Gle1 and inositol hexakisphosphate (IP(6)) play an essential role

61 It was recently shown that myo-inositol hexakisphosphate (IP(6)) stimulates the joining

62 inositol pyrophosphate synthesis, converting inositol hexakisphosphate (IP(6)) to IP(7).

63 Inositol hexakisphosphate (IP(6)) was previously found t

64 Despite the high deposition of inositol hexakisphosphate (IP(6)), also known as phytate

65 yme at the branch point for the synthesis of inositol hexakisphosphate (IP(6)), an intracellular sign

66 n of highly phosphorylated inositols, mostly inositol hexakisphosphate (IP(6)), detected in HEK293 ce

67 ity of DEAD-box protein Dbp5 is activated by inositol hexakisphosphate (IP(6))-bound Gle1 to mediate

68 hich can be further phosphorylated to become inositol hexakisphosphate (IP(6)).

69 inositol phosphate PIP(3), or in solution by inositol hexakisphosphate (IP(6)).

70 itol 1,3,4,5,6-pentakisphosphate (IP(5)) and inositol hexakisphosphate (IP(6)).

71 n of Dbp5's ATPase activity by Gle1 bound to inositol hexakisphosphate (IP(6)).

72 pJ and identify this activating factor to be inositol hexakisphosphate (IP(6)).

73 function is dependent on the small molecule inositol hexakisphosphate (IP(6)).

74 y showed that arrestin-3 can be activated by inositol-hexakisphosphate (IP(6)).

75 ), inositol 1,4,5-trisphosphate (IP3 ), and inositol hexakisphosphate (IP6 ) in T. brucei different

76 ive capsomers in the presence and absence of inositol hexakisphosphate (IP6) and cyclophilin A and co

77 re we report the characterization of a human inositol hexakisphosphate (IP6) and diphosphoinositol pe

78 Vip1 and Asp1 acted as enzymes that encode inositol hexakisphosphate (IP6) and inositol heptakispho

79 The cellular metabolite inositol hexakisphosphate (IP6) binds and stabilizes the

80 The cellular metabolite inositol hexakisphosphate (IP6) binds the HIV-1 capsid,

81 sphate, is synthesized on phosphorylation of inositol hexakisphosphate (IP6) by IP6 kinases, of which

82 Production of inositol hexakisphosphate (IP6) by Ipk1, the inositol-1,

83 hermore, binding of the host cell metabolite inositol hexakisphosphate (IP6) enhances dNTP import, wh

84 Recently, inositol hexakisphosphate (IP6) has been identified as a

85 The cellular polyanion inositol hexakisphosphate (IP6) has recently been demons

86 family of enzymes in charge of synthesizing inositol hexakisphosphate (IP6) in eukaryotic cells.

87 key characteristics, notably the absence of inositol hexakisphosphate (IP6) in the SRLV CA lattice-a

88 Inositol hexakisphosphate (IP6) inhibits nucleosome mobi

89 Myo-inositol hexakisphosphate (IP6) is a natural product kno

90 Here, we show that inositol hexakisphosphate (IP6) is a non-receptor activa

91 Among the different inositol phosphates, inositol hexakisphosphate (IP6) is a substrate of inosit

92 Inositol hexakisphosphate (IP6) is an assembly cofactor

93 Unexpectedly, inositol hexakisphosphate (IP6) is buried within the enz

94 Intriguingly, inositol hexakisphosphate (IP6) is dispensable for HTLV-

95 e eukaryote-specific host signaling molecule inositol hexakisphosphate (IP6) is required for Lpg2603

96 his question, we have previously purified an inositol hexakisphosphate (IP6) kinase from rat brain su

97 We have purified an inositol hexakisphosphate (IP6) kinase from rat brain su

98 nd are formed primarily by a family of three inositol hexakisphosphate (IP6) kinases (IP6K1-3).

99 We subsequently demonstrate that a myo-inositol hexakisphosphate (IP6) noncovalent adduct can s

100 Inositol hexakisphosphate (IP6) promotes HIV-1 assembly

101 tion, RNA binding, and the assembly cofactor inositol hexakisphosphate (IP6) synergize to generate im

102 We have now explored the binding of inositol hexakisphosphate (IP6) to Gag and its effects u

103 IP6Ks phosphorylate inositol hexakisphosphate (IP6) to the pyrophosphate, 5-

104 Previously, inositol hexakisphosphate (IP6) was shown to be bound by

105 phate, inositol pentakisphosphate (IP5), and inositol hexakisphosphate (IP6)) in rat cells.

106 However, inositol hexakisphosphate (IP6), a fairly abundant form

107 linositol triphosphate (PIP3), we found that inositol hexakisphosphate (IP6), a soluble signaling mol

108 ruses in the presence and absence of BVM and inositol hexakisphosphate (IP6), an assembly cofactor.

109 inhibitor PF-46396 and the assembly cofactor inositol hexakisphosphate (IP6), determined by magic ang

110 Myo-inositol hexakisphosphate (IP6), is the main iron chelat

111 mational change of HopZ1a in the presence of inositol hexakisphosphate (IP6), which acts as a eukaryo

112 ntration or exclusion of the molecule (e.g., inositol hexakisphosphate (IP6), which stabilizes the vi

113 inositol 1,3,4,5-tetrakisphosphate (IP4) and inositol hexakisphosphate (IP6).

114 r messenger RNA export through production of inositol hexakisphosphate (IP6).

115 om phosphatidylinositol 4, 5-bisphosphate to inositol hexakisphosphate (IP6).

116 vitro by binding to the host cell metabolite inositol hexakisphosphate (IP6).

117 plexed with BVM and/or the assembly cofactor inositol hexakisphosphate (IP6).

118 structure further reveals that Pds5 can bind inositol hexakisphosphate (IP6).

119 inositol 1,3,4,5,6-pentakisphosphate(IP5) to inositol hexakisphosphate (IP6).

120 is modulated by the intracellular molecule, inositol-hexakisphosphate (IP6).

121 Phytate (inositol hexakisphosphate, IP6) is a regulator of intrac

122 ates from inositol pentakisphosphate but not inositol hexakisphosphate is indispensable for optimal I

123 g-Zipper protein also assembles correctly if inositol hexakisphosphate is supplemented with other pol

124 Phytic acid (myo-inositol hexakisphosphate) is the major storage form of

125 isphosphate 2-kinase (Ipk1), which generates inositol hexakisphosphate, is critical for normal LR axi

126 r phosphate homeostasis, here we knocked out inositol hexakisphosphate kinase (IP6K) 1 and IP6K2 to g

127 nserved in two human small-molecule kinases, inositol hexakisphosphate kinase (IP6K) and inositol pol

128 the synthesis of inositol pyrophosphates by inositol hexakisphosphate kinase (IP6K) has been identif

129 itol pentakisphosphate 2-kinase (TbIP5K) and inositol hexakisphosphate kinase (TbIP6K).

130 Here we demonstrate that disruption of inositol hexakisphosphate kinase 1 (InsP6K1), one of the

131 s demonstrated that nuclear translocation of inositol hexakisphosphate kinase 1 (IP6K1) mediates repr

132 Inositol hexakisphosphate kinase 1 (IP6K1) participates

133 Here, we demonstrate that inositol hexakisphosphate kinase 1 (IP6K1), the enzyme r

134 Inositol hexakisphosphate kinase 1 (IP6K1), which genera

135 Accordingly, inositol hexakisphosphate kinase 1-2 (IP6K1-2) gene inac

136 We previously showed that inositol hexakisphosphate kinase 2 (IHPK2) functions as

137 We recently identified inositol hexakisphosphate kinase 2 (IP6K2) as a positive

138 The inositol hexakisphosphate kinase 2 (IP6K2) controls cell

139 A new target gene, coding for inositol hexakisphosphate kinase 2 (IP6K2) was identifie

140 Inositol hexakisphosphate kinase 2 (IP6K2), a member of

141 s revealed that RID-2 was identical to human inositol hexakisphosphate kinase 2 (IP6K2).

142 sphosphate kinase 2 (IP6K2), a member of the inositol hexakisphosphate kinase family, functions as a

143 1-1, that is predicted to encode a conserved inositol hexakisphosphate kinase from the VIP family tha

144 In this study, we report that IP6K1, an inositol hexakisphosphate kinase that catalyzes the synt

145 We found that cells lacking inositol hexakisphosphate kinase, which is responsible f

146 (Hh) signaling for the IP kinase designated inositol hexakisphosphate kinase-2 (IP6K2) that produces

147 Inositol hexakisphosphate kinase-2 (IP6K2), one of a fam

148 Inositol hexakisphosphate kinase-2 (IP6K2), one of the m

149 Inositol hexakisphosphate kinase-2 (IP6K2), which genera

150 isiae, extracellular [Pi] is "sensed" by the inositol-hexakisphosphate kinase (IP6K) that synthesizes

151 e synthesized by a recently cloned family of inositol hexakisphosphate kinases (InsP(6)Ks).

152 exakisphosphate (InsP6) by a family of three inositol hexakisphosphate kinases (InsP6K).

153 nase 1 (InsP6K1), one of the three mammalian inositol hexakisphosphate kinases (InsP6Ks) that convert

154 In yeast and plants, inositol hexakisphosphate kinases (IP6Ks) are central to

155 Inositol hexakisphosphate kinases (IP6Ks) are emerging a

156 The inositol hexakisphosphate kinases (IP6Ks) are the princi

157 Inositol trisphosphate kinases (IP3Ks) and inositol hexakisphosphate kinases (IP6Ks) each regulate

158 Inositol hexakisphosphate kinases (IP6Ks) have been stud

159 Inositol hexakisphosphate kinases (IP6Ks) regulate vario

160 We identified and cloned a family of three inositol hexakisphosphate kinases (IP6Ks) that generate

161 takisphosphate), formed by a family of three inositol hexakisphosphate kinases (IP6Ks), modulates div

162 hosphate (IP7), are generated by a family of inositol hexakisphosphate kinases (IP6Ks), of which IP6K

163 hosphate (IP7), are generated by a family of inositol hexakisphosphate kinases (IP6Ks), of which IP6K

164 are generated primarily by a family of three inositol hexakisphosphate kinases (IP6Ks), the principal

165 tol hexakisphosphate (IP6) is a substrate of inositol hexakisphosphate kinases (IP6Ks), which phospho

166 , 1 mM Km for ATP) of the 5-InsP7-generating inositol hexakisphosphate kinases (IP6Ks).

167 They are formed by a family of inositol hexakisphosphate kinases (IP6Ks).

168 zyl), N6-(p-nitrobenzyl) purine], to inhibit inositol hexakisphosphate kinases upstream of PPIP5Ks.

169 IP7 is produced in mammals by a family of inositol hexakisphosphate kinases, IP6K1, IP6K2, and IP6

170 ular P(i) accumulated following knockdown of inositol hexakisphosphate kinases.

171 inases, inositol phosphate multikinases, and inositol hexakisphosphate kinases.

172 IP(7) and IP(8), synthesized respectively by inositol-hexakisphosphate kinases (IP6Ks) and diphosphoi

173 myl-Met-Leu-Phe, platelet-activating factor, inositol hexakisphosphate, lipopolysaccharide, leukotrie

174 Phytate (myo-inositol hexakisphosphate, myo-IHP) is one of the most c

175 levels of either inositol pentakisphosphate, inositol hexakisphosphate or other diphosphorylated inos

176 is Bifidobacterium strain contributed to myo-inositol hexakisphosphate (phytate) hydrolysis, resultin

177 In these habitats, myo-inositol hexakisphosphate (phytate) is prevalent and use

178 Our data suggest that the pathway for inositol hexakisphosphate production is a key regulator

179 Soluble -myo-inositol hexakisphosphate shows converse behavior.

180 cells, albeit at low levels as compared with inositol hexakisphosphate synthesis.

181 teric binding by the endogenous cofactor myo-inositol hexakisphosphate to orchestrate self-cleavage f

182 However, neo- and d-chiro-inositol hexakisphosphates were recently revealed in bot

183 virions contain high concentrations of IP6 (inositol hexakisphosphate), which stabilize capsids by b

184 urther buttressed by the endogenous cofactor inositol hexakisphosphate, which acts as a second molecu