ライフサイエンスコーパス: inositol phosphatase

1 SHIP-1 (Src homology [SH2] domain-containing inositol phosphatase).

2 e SopE-dependent activation of an endogenous inositol phosphatase.

3 vity, thus implicating the involvement of an inositol phosphatase.

4 2) domain-containing cytoplasmic tyrosine or inositol phosphatases.

5 (SHP) 2 and Src homology domain 2-containing inositol phosphatase 1 (SHIP-1) and internalization of I

6 EAT-2 was mediated by SH2 domain-containing inositol phosphatase 1 (SHIP-1), which was recruited via

7 turn, miR-155 down-regulates SH2-containing inositol phosphatase 1 (SHIP1), thereby increasing phosp

8 I3K), or 5' Src homology 2 domain-containing inositol phosphatase 1 (SHIP1).

9 The SH2-containing inositol phosphatase-1 (SHIP-1) is a 5' inositol phospha

10 Src Homology 2-containing Inositol Phosphatase-1 (SHIP-1) is a target of miR-155,

11 SH2 domain-containing inositol phosphatase-1 (SHIP-1) is phosphorylated on Y10

12 The results indicate that scaffolding of inositol phosphatase activity is critical for maintainin

13 SHIP1 to be phosphorylated and stimulate its inositol phosphatase activity.

14 ding evidence that Src homology 2 containing inositol phosphatase, an inhibitor of NF-kappaB activati

15 kines and the upregulation of SH2-containing inositol phosphatase, an inhibitor of NF-kappaB signalin

16 and expression of Src homology 2-containing inositol phosphatase and Src homology 2-containing prote

17 ember function: first, several targets of an inositol-phosphatase-dependent inhibitory signaling path

18 ortance of the tyrosine phosphatases and the inositol phosphatase differs depending on the cell type.

19 int mutations of the signature motifs in the inositol phosphatase domain abolish SHIP's ability to in

20 atic mutagenesis approach, we identified the inositol phosphatase domain of SHIP between amino acids

21 An inactivating mutation (R258Q) in the Sac inositol phosphatase domain of synaptojanin 1 (SJ1/PARK2

22 Here, we demonstrate that the 5'-inositol phosphatase gene, inppl1a, regulates notochord

23 is novel protein, p150(ship) (SH2-containing inositol phosphatase), identifies a component of a new g

24 In this study, we show that inositol phosphatase interacting protein of 27 kDa (Ipip

25 nositol phosphatase) or SHIP (SH2-containing inositol phosphatase) is a recently identified SH2 domai

26 ning inositol phosphatase-1 (SHIP-1) is a 5' inositol phosphatase known to negatively regulate the pr

27 SHIP1 is a 5'-inositol phosphatase known to negatively regulate the si

28 SHIP2, a 5'-inositol phosphatase, localizes at the invadopodium core

29 IPIP27 scaffolds the inositol phosphatase oculocerebrorenal syndrome of Lowe

30 usly identified as Src homology 2-containing inositol phosphatase, only under conditions of negative

31 SIP (signaling inositol phosphatase) or SHIP (SH2-containing inositol p

32 The inositol phosphatases phosphatase and tensin homologue (

33 me 10 or src homology 2 domain-containing 5' inositol phosphatase, phosphatases that negatively regul

34 the Dictyostelium genome called phospholipid-inositol phosphatase (PLIP), which defines a new subfami

35 ase (pBtk) and phosphorylated SH2-containing inositol phosphatase (pSHIP), are reduced and enhanced,

36 y, experiments identify up-regulation of the inositol phosphatase PTEN (phosphatase and tensin homolo

37 mmatory signaling by direct targeting of the inositol phosphatase PTEN, the signaling inhibitor SOCS1

38 CD19, as well as increased expression of the inositol phosphatase PTEN.

39 le signaling enzymes and is regulated by the inositol phosphatases PTEN (phosphatase and tensin homol

40 nts of protein-tyrosine phosphatase-like myo-inositol phosphatases (PTPLPs) from the non-pathogenic b

41 Disruption of the negative signaling inositol phosphatase, SH2-containing inositol-5-phosphat

42 The inositol phosphatase SHIP binds to the FcgammaRIIB1 rece

43 The inositol phosphatase SHIP has been implicated in signali

44 SHP-1 and -2 and the novel 5'-inositol phosphatase SHIP have recently been shown to fu

45 Activity of the inositol phosphatase SHIP is required for this negative

46 B cells results in the recruitment of the 5'-inositol phosphatase SHIP to the signaling complex.

47 resulted in enhanced phosphorylation of the inositol phosphatase SHIP, association of SHIP with Shc,

48 lving the tyrosine phosphatase SHP-1 and the inositol phosphatase SHIP-1 are required to maintain ane

49 Although the inositol phosphatase SHIP-1 is generally thought to inhi

50 y Fc gamma RIIa is tightly controlled by the inositol phosphatase SHIP-1, and the protein-tyrosine ph

51 cells by the expression and function of the inositol phosphatase SHIP-2.

52 gate MPN-like disease in animals lacking the inositol phosphatase SHIP.

53 tivation, and its intracellular effector the inositol phosphatase SHIP.

54 ein tyrosine phosphatase SHP-1 and SHP-2 and inositol phosphatase SHIP.

55 tion mediated by Fc gamma RIIb1 requires the inositol phosphatase SHIP.

56 ng by the tyrosine phosphatase SHP-1 and the inositol phosphatases SHIP-1 and PTEN to maintain unresp

57 ly identified as an SH2 domain containing 5'-inositol phosphatase (SHIP) and has been implicated in t

58 uggest that the receptor uses SH2-containing inositol phosphatase (SHIP) and SH2-containing phosphoty

59 current study, the effect of SH2-containing inositol phosphatase (SHIP) expression on these biologic

60 We find that SH2-containing inositol phosphatase (SHIP) influences the repertoire of

61 SH2-containing Inositol Phosphatase (SHIP) is a 145 kD protein expresse

62 ough the Src homology 2 domain-containing 5' inositol phosphatase (SHIP) is a well-known mediator of

63 atase Src homology 2 (SH2) domain-containing inositol phosphatase (SHIP) is phosphorylated and associ

64 de, we have found that the SH2-containing 5'-inositol phosphatase (SHIP) is phosphorylated on tyrosin

65 (PTEN) and Src homology 2 domain-containing inositol phosphatase (SHIP) negatively regulate phosphat

66 h IL-4R alpha signals Shc and SH2-containing inositol phosphatase (SHIP) phosphorylation, we could no

67 a the Src homology region 2 (SH2)-containing inositol phosphatase (SHIP) SH2 domain.

68 is pathway is blocked when an SH2-containing inositol phosphatase (SHIP)-dependent inhibitory recepto

69 rformed by the 145-kDa SH2 domain-containing inositol phosphatase (SHIP).

70 (PTEN) and Src homology 2 domain-containing inositol phosphatase (SHIP-1), which hydrolyze PI(3,4,5)

71 tyrosine phosphorylation or activity of the inositol phosphatase, SHIP, in Lyn(-/-) BMMCs.

72 and the binding of the SH2 domain-containing inositol phosphatase, SHIP, to Fc gamma RIIB1.

73 bition is mediated by the recruitment of the inositol phosphatase, SHIP, to the Fc gammaRIIB1 phospho

74 reduction of tyrosine phosphorylation of the inositol phosphatase, SHIP.

75 d, in part, via diminished expression of the inositol phosphatase SHIP1 and increased activation of E

76 is associated with phosphorylation of the 5-inositol phosphatase SHIP1 and requires SHIP1 expression

77 The Src homology 2-containing inositol phosphatase SHIP1 functions in hemopoietic cell

78 in part via miR-155's direct effects on the inositol phosphatase SHIP1.

79 Mena also interacts with the 5' inositol phosphatase SHIP2, which is important for the r

80 SH2 domain-containing 5-inositol phosphatase (SHIP2) is implicated in the develo

81 phosphatase genes, including SH2-containing inositol phosphatase (Ship2).

82 Here we investigate the role of the 5'-inositol phosphatase, SHIP2, and reveal an unexpected sc

83 Our recent studies revealed that the inositol phosphatase Src homology 2 (SH2) domain-contain

84 atase and tensin homolog), or SH2-containing inositol phosphatase suppressed the Btk(lo) phenotype in

85 In contrast, the 5'-inositol phosphatase synaptojanin 1 localizes to CCPs an

86 SHIP is an inositol phosphatase that can reverse the activation eve

87 SHIP1 is a 5' inositol phosphatase that dephosphorylates the phosphati

88 SHIP is an inositol phosphatase that downregulates PI3K-mediated ac

89 Among several inositol phosphatases that regulate the availability of

90 such as Fc epsilon RI, recruit tyrosine and inositol phosphatases that results in diminished calcium

91 The recruitment of inositol phosphatases to endocytic membranes mediates de

92 ing hemITAM can also couple to intracellular inositol phosphatases to modulate selected functional re

93 as SKIP (skeletal muscle and kidney enriched inositol phosphatase), which is highly expressed in the

94 t study we have demonstrated that SHIP-2, an inositol phosphatase with high-level homology to SHIP-1,