ライフサイエンスコーパス: insecticide resistance

1 r understanding of the molecular genetics of insecticide resistance.

2 lutionary and heritable feature and roles in insecticide resistance.

3 from metabolic families previously linked to insecticide resistance.

4 ding of the molecular basis and evolution of insecticide resistance.

5 of the most important mechanisms involved in insecticide resistance.

6 to evolutionary pressures, thereby avoiding insecticide resistance.

7 and controlled vocabularies for anatomy and insecticide resistance.

8 most have not previously been implicated in insecticide resistance.

9 t nervous system is known to be important in insecticide resistance.

10 ween kdr allele expression and the levels of insecticide resistance.

11 insecticides, leading to the development of insecticide resistance.

12 laria control, particularly in areas of high insecticide resistance.

13 sion level of an adjacent gene which creates insecticide resistance.

14 lex, suggest that this AO may play a role in insecticide resistance.

15 nt part in understanding both antibiotic and insecticide resistance.

16 gulatory mutations playing a central role in insecticide resistance.

17 ction of the normal gene product can lead to insecticide resistance.

18 stigate the role of CNVs in the evolution of insecticide resistance.

19 vectors and enhances our capacity to manage insecticide resistance.

20 l is being undermined by the rapid spread of insecticide resistance.

21 malaria control in settings with widespread insecticide resistance.

22 ding new evidence of their potential role in insecticide resistance.

23 of other important biological traits such as insecticide resistance.

24 ological plasticity and potential to develop insecticide resistance.

25 the hypothesis of antiviral resistance over insecticide resistance.

26 plementation of new technologies that manage insecticide resistance.

27 accuracy of 0.75 when identifying cuticular insecticide resistance.

28 ase its burden, although it is threatened by insecticide resistance.

29 ontrol tools that prevent the development of insecticide resistance.

30 ising concerns over the potential impacts of insecticide resistance.

31 iciliation, dispersal, feeding behavior, and insecticide resistance.

32 to identify candidate genes associated with insecticide resistance.

33 ethal effects, and associated development of insecticide resistance.

34 tially mitigate the global health effects of insecticide resistance.

35 xisting chemical control strategies to avert insecticide resistance.

36 entation of new technologies that circumvent insecticide resistance.

37 tegies most likely to minimise the spread of insecticide resistance.

38 ation of association between the Vgsc CN and insecticide resistance.

39 ated with speciation, ecological habitat and insecticide resistance.

40 y undermines vector control programs through insecticide resistance.

41 d LLIN effectiveness in the presence of high insecticide resistance.

42 iont interactions, and several mechanisms of insecticide resistance.

43 ave important implications for the spread of insecticide resistance.

44 ecting the insecticide against the spread of insecticide resistance.

45 nsporters have previously been implicated in insecticide resistance.

46 ravel and commerce in addition to widespread insecticide resistance.

47 ya vector, is threatened by growing cases of insecticide resistance.

48 proteins-or genes are likely responsible for insecticide resistance.

49 ance, nutrition, reproduction, genetics, and insecticide resistance.

50 ology, interactions with the host animal and insecticide resistance.

51 species identification (cox-1 and its2) and insecticide resistance (ace-1, GSTe2, vgsc and rdl).

52 e mutations is a common event in response to insecticide resistance across different Cx. quinquefasci

53 Insecticide resistance across sub-Saharan Africa may imp

54 e prevalence of genetic markers of Anopheles insecticide resistance across the DRC and provide an imp

55 sed tools such as bednets are compromised by insecticide-resistance alleles for which there is also a

56 divergence island, which includes a suite of insecticide-resistance alleles.

57 Rapid spread of insecticide resistance among anopheline mosquitoes threa

58 cant selection pressure for the evolution of insecticide resistance among major malaria vector specie

59 Insecticide resistance amongst disease vectors is a grow

60 Escalating levels of insecticide resistance and adaptive changes in mosquito

61 cent back-to-Africa Aaa migration introduced insecticide resistance and anthropophily into regions wi

62 Our research highlights the presence of insecticide resistance and associated mutations in Puert

63 d elimination is threatened by the spread of insecticide resistance and behavioral adaptation of vect

64 is has been attributed to the development of insecticide resistance and behavioural adaptations in ma

65 me fusion brought two major genes conferring insecticide resistance and clusters of genes involved in

66 ing a point mutation in the active site show insecticide resistance and defects in gravity sensing.

67 en helpful, but they face challenges such as insecticide resistance and environmental harm.

68 ritically needed, especially with widespread insecticide resistance and global climate change.

69 transmission that assesses the evolution of insecticide resistance and immunity in the human populat

70 e also observed low copy number variation in insecticide resistance and immunity-related genes for al

71 he An. funestus group and review research on insecticide resistance and its mechanisms.

72 Rising insecticide resistance and lack of efficacious vaccines

73 Increasing concerns for insecticide resistance and larvicide safety are limiting

74 emics in later years because of evolution of insecticide resistance and loss of herd immunity.

75 get to develop new insecticides with reduced insecticide resistance and low toxicity to mammals, fish

76 Insecticide resistance and outdoor transmission have red

77 locus of Drosophila melanogaster that confer insecticide resistance and persist at intermediate frequ

78 y in sub-Saharan Africa, because of drug and insecticide resistance and social and environmental chan

79 annel of resistant mosquitoes in response to insecticide resistance and the inheritance of these muta

80 articular importance due to the evolution of insecticide resistance and the proposed release of trans

81 of gene expression signatures associated to insecticide resistance and their suppression could great

82 osquitoes is threatened by the appearance of insecticide resistance and therefore new control chemica

83 to identify the contribution of each CNV to insecticide resistance and to track their spread as the

84 Beyond this, indirect impacts of insecticide resistance and/or exposure on mosquito longe

85 he proximity of genes relevant for immunity, insecticide resistance, and development.

86 anding of basic disease biology and drug and insecticide resistance, and have informed vaccine develo

87 We stratified studies into three levels of insecticide resistance, and ITNs were compared with untr

88 evidence suggest that P450 genes involved in insecticide resistance, and perhaps insecticide detoxifi

89 e involvement of miRNAs in the regulation of insecticide resistance, and shed light on the novel targ

90 he earth's climate, antimalarial resistance, insecticide resistance, and socioeconomic decline test t

91 flexible, two-locus model for the spread of insecticide resistance applicable to mosquito species th

92 malaria vector species and the monitoring of insecticide resistance are essential to inform malaria c

93 Barrier bednets that overcome insecticide resistance are feasible using existing insec

94 on era, it is vital that the implications of insecticide resistance are understood and strategies to

95 hat interpretations of species compositions, insecticide resistance assays, host preference studies,

96 a therefore suggest that multiple origins of insecticide resistance (associated with specific point m

97 ve facilitated a genome-wide analysis of the insecticide resistance-associated genes in insects.

98 ispersive Culex mosquito have suggested that insecticide resistance-associated mutations (specificall

99 Such an insecticide-resistance-associated minigene should form a

100 Differing levels of insecticide resistance between two African malaria vecto

101 of infectious disease through antibiotic and insecticide resistance, but recent theory suggests disea

102 detoxifying enzymes has been associated with insecticide resistance, but their direct functional vali

103 P450 monooxygenases play a critical role in insecticide resistance by allowing resistant insects to

104 Synergists can counteract metabolic insecticide resistance by inhibiting detoxification enzy

105 Insecticide resistance can arise from a variety of mecha

106 cing was used to investigate the presence of insecticide resistance-conferring mutations in nine targ

107 simultaneously detect Plasmodium infection; insecticide resistance-conferring SNPs in ace1, gste2, v

108 aracterized- Cub and Sushi Domain containing Insecticide Resistance (CSDIR) protein and generated evi

109 ogy resource for storing genomic variations, insecticide resistance data and their associated metadat

110 ed populations in response to high levels of insecticide resistance, demonstrating that the co-existe

111 es associated with hematophagy, immunity and insecticide resistance, directly involved in vector-huma

112 o assist the high-throughput surveillance of insecticide resistance, discriminate between sibling spe

113 The directional selection for insecticide resistance due to indiscriminate use of inse

114 Insecticide resistance escalation is decreasing the effi

115 C. elegans as a model organism for studying insecticide resistance evolution.

116 llows progress in the analysis of cyclodiene insecticide resistance from the initial isolation of the

117 alyze the allele replacement observed in the insecticide resistance gene Ester in the mosquito Culex

118 al inversions in one chromosome arm (2R), an insecticide resistance gene on 2L, and this single X-lin

119 n which we model the evolution and spread of insecticide resistance genes and also suggest that paral

120 id not appear to be directly associated with insecticide-resistance genes.

121 control, for understanding the mechanisms of insecticide resistance, genetic adaptation to high patho

122 h populations and improving health outcomes, insecticide resistance has been a consistent barrier to

123 t role played by P450s in the development of insecticide resistance has been extensively studied but

124 Insecticide resistance has been reported across Anophele

125 Whilst insecticide resistance has been widely investigated, the

126 Insecticide resistance has decreased the efficacy of the

127 Insecticide resistance has emerged as a persistent threa

128 ciated diseases.(1) Additionally, widespread insecticide resistance has reduced the efficacy of curre

129 Fitness-related costs of evolving insecticide resistance have been reported in a number of

130 owever, measurements of the fitness costs of insecticide resistance have used diverse methods to cont

131 ating malaria, several challenges, including insecticide resistance, have hindered progress in fighti

132 ndation for future research on mechanisms of insecticide resistance, human-bed bug and symbiont-bed b

133 Mitigating the threat of insecticide resistance in African malaria vector populat

134 ded method for the molecular surveillance of insecticide resistance in An. funestus populations.

135 ssist in the high-throughput surveillance of insecticide resistance in An. stephensi populations.

136 r efficacies are declining due to widespread insecticide resistance in Anopheles mosquito populations

137 esistance to antimalarials, the emergence of insecticide resistance in Anopheles mosquito species rem

138 e potential contribution of agrochemicals to insecticide resistance in Anopheles mosquitoes breeding

139 stics that we used to confirm persistence of insecticide resistance in California, U.S.A. To validate

140 otype previously shown to be associated with insecticide resistance in Drosophila melanogaster.

141 eptor (RyR) was highly correlated to diamide insecticide resistance in field populations of Plutella

142 However, data on insecticide resistance in Guinea-Bissau is limited.

143 ntrol is now threatened by alarming rates of insecticide resistance in insect populations, prompting

144 Insecticide resistance in malaria vector populations pos

145 Insecticide resistance in malaria vectors could presage

146 Assessing patterns and evolution of insecticide resistance in malaria vectors is a prerequis

147 production could influence the selection for insecticide resistance in malaria vectors.

148 is study investigated the molecular basis of insecticide resistance in Malaysian populations of Ae. a

149 of tolerance has influenced the evolution of insecticide resistance in managed systems and the evolut

150 gene regulation governing the development of insecticide resistance in mosquitoes and discusses the p

151 lation system involved in the development of insecticide resistance in mosquitoes Culex quinquefascia

152 Past investigations on the emergence of insecticide resistance in mosquitoes mostly relied on fi

153 their precise function in the development of insecticide resistance in mosquitoes will provide new in

154 drug resistance in the Plasmodium parasites, insecticide resistance in mosquitoes, and the lack of an

155 In the wake of the development of insecticide resistance in mosquitoes, novel strategies f

156 erexpressed P450 genes in the development of insecticide resistance in mosquitoes.

157 rted arboviral cases and by the emergence of insecticide resistance in mosquitoes.

158 ifications and polymorphisms associated with insecticide resistance in mosquitoes.

159 Given the spread of insecticide resistance in natural mosquito populations,

160 Africa, but their efficacy is threatened by insecticide resistance in some malaria mosquito vectors.

161 generated evidence for its role in mediating insecticide resistance in the Anopheles stephensi.

162 nzymes have been associated with the diamide insecticide resistance in the diamondback moth, Plutella

163 The role of cuticle changes in insecticide resistance in the major malaria vector Anoph

164 rica is imperilled by the rapid evolution of insecticide resistance in the major vector Anopheles gam

165 The emergence of insecticide resistance in the mosquito poses a serious t

166 been an increase in the number of reports of insecticide resistance in the past ten years.

167 number of independent origins of cyclodiene insecticide resistance in the red flour beetle Tribolium

168 erlie the fitness trade-offs associated with insecticide resistance in the whitefly Bemisia tabaci.

169 pact of gene drives as well as the spread of insecticide resistance in the wild.

170 sents a mechanism for the rapid evolution of insecticide resistance in this important vector of human

171 ukii management, resulting in development of insecticide resistance in this pest.

172 about the molecular markers associated with insecticide resistance in this species.

173 elling strategy to investigate the spread of insecticide resistance in vector populations and demonst

174 ering a significant step forward in managing insecticide resistance in vector-control operations.

175 The increase of insecticide resistance in wild populations of Anopheles

176 Genetic changes in insects that lead to insecticide resistance include point mutations and up-re

177 h metabolic genes previously associated with insecticide resistance, including cyp9k1 and the cyp6aa/

178 morphisms (SNPs) potentially associated with insecticide resistance, including three SNPs found in th

179 ring of occurrence, levels and mechanisms of insecticide resistance informs effective management stra

180 cticide resistance phenotypes and genotypes. Insecticide resistance intensity CDC bioassays were empl

181 ucted seminal field studies to compare three insecticide resistance intervention strategies for cockr

182 However, rising insecticide resistance (IR) among mosquito populations,

183 r, this intervention has prompted widespread insecticide resistance (IR) and been associated with cha

184 ated sodium channel have an influence on the insecticide resistance (IR) phenotype.

185 in combating malaria, however the increasing insecticide resistance (IR) poses a challenge.

186 Insecticide resistance (IR) poses a significant global c

187 Insecticide resistance is a growing threat to mosquito c

188 Insecticide resistance is a major obstacle to control of

189 Insecticide resistance is a model phenotype that can be

190 Insecticide resistance is a multifaceted response and an

191 Insecticide resistance is a paradigm of microevolution,

192 Insecticide resistance is an ideal model to study the em

193 nagement enables potato production, although insecticide resistance is becoming an issue.

194 The evolution of insecticide resistance is conferred through mechanisms,

195 Monitoring local mosquito populations for insecticide resistance is critical for effective vector-

196 Understanding the molecular basis of insecticide resistance is key to improve the surveillanc

197 Insecticide resistance is one of the most prevalent exam

198 Insecticide resistance is one of the most widespread gen

199 rrupt disease transmission; however, growing insecticide resistance is threatening to reverse gains i

200 One way to mitigate insecticide resistance is to directly kill parasites dur

201 Insecticide resistance is typically associated with alte

202 s a potential biopesticide to counteract the insecticide resistance issue in mosquitoes.

203 Insecticide resistance jeopardizes the prevention of inf

204 ontrol and eradication is challenging due to insecticide resistance, lack of effective products, and

205 to investigate the genetic diversity in four insecticide resistance linked genes: ace-1, GSTe2, rdl a

206 However, we find signatures of selection at insecticide resistance loci that appear ubiquitous acros

207 burden and the continued spread of drug and insecticide resistance make malaria elimination both via

208 Rampant insecticide resistance makes controlling these mosquitoe

209 Insecticide resistance management (IRM) is critical to m

210 s used provide a template for evidence-based insecticide resistance management by malaria control pro

211 This will be a major advance for insecticide resistance management in malaria vectors, wh

212 The implications of insecticide resistance management of B. tabaci on Indian

213 w being reintroduced for IRS in a rotational insecticide resistance management program.

214 The implementation of successful insecticide resistance management strategies for malaria

215 A major impediment to the implementation of insecticide resistance management strategies is that evi

216 a vector control and the design of proactive insecticide resistance management strategies.

217 asmodium falciparum infection, and molecular insecticide resistance mechanisms in Guinea.

218 With the exception of target site mutations, insecticide resistance mechanisms in the principle malar

219 An understanding of insecticide resistance mechanisms would help to develop

220 Characterization of molecular insecticide resistance mechanisms, using novel amplicon-

221 ndicating that neither tissue is involved in insecticide resistance mediated by the candidate P450s e

222 ic pests, veterinary/medical entomology, and insecticide resistance monitoring.

223 esolved data such as vector surveillance and insecticide resistance monitoring.

224 contribute significantly to the evolution of insecticide resistance, most commonly by increasing the

225 Nationwide geographical trends in insecticide resistance mutation distribution, prevalence

226 recent introgression of a strongly selected insecticide-resistance mutation (Vgsc-1014F) located wit

227 y using amplicon-sequencing to monitor known insecticide resistance mutations, with the potential to

228 ersity, population structure, and uncovering insecticide resistance mutations.

229 Increasing insecticide resistance necessitates discovery of novel c

230 s for insect pest management has resulted in insecticide resistance now being recorded in >500 specie

231 n, suggests the involvement of copper in the insecticide resistance of malaria vectors; this, however

232 function of GPCRs and GPCR-related genes in insecticide resistance of mosquitoes, Culex quinquefasci

233 ant to antimalarial drugs and the increasing insecticide resistance of mosquitoes-may cause the numbe

234 istance to antimalarial drugs and increasing insecticide resistance of the vector threaten to reduce

235 The impact of insecticide resistance on insect-borne disease programs

236 The detrimental impact of insecticide resistance on mating competiveness observed

237 studies directly assessing the influence of insecticide resistance on mosquito fitness.

238 ts epidemiological importance, the impact of insecticide resistance on vector-parasite interactions a

239 Mosquitoes with phenotypes that exhibit insecticide resistance or experience sublethal effects m

240 he spread of genes, such as genes conferring insecticide resistance or possibly refractoriness to par

241 ed our understanding of the genetic basis of insecticide resistance over the last decade, we still kn

242 ent agenda, the potential negative impact of insecticide resistance, particularly on LLINs, for which

243 Our study shows the complexity of insecticide resistance patterns and underlying mechanism

244 In this study, we monitored insecticide resistance patterns, vector population biono

245 regions of Puerto Rico to investigate their insecticide resistance phenotypes and genotypes. Insecti

246 nalysis using the GAL4/UAS system to examine insecticide resistance phenotypes conferred by increased

247 f the environmental background in developing insecticide resistance phenotypes, and caution for the i

248 population genetics including variation and insecticide-resistance phenotypes.

249 Global insecticide resistance phenotypic data demonstrated vari

250 Insecticide resistance poses a major challenge to sustai

251 Insecticide resistance poses a serious threat to current

252 Insecticide resistance poses a serious threat to insecti

253 Insecticide resistance poses a significant and increasin

254 Our findings of the insecticide resistance profile, coupled with the likely

255 abundance, and whitefly's ability to develop insecticide resistance rapidly often render the commonly

256 in but also repressed the expression of four insecticide resistance-related P450 genes, suggesting th

257 iological functions of P450s associated with insecticide resistance remain largely unknown.

258 The role of miRNAs in mediating insecticide resistance remains largely unknown, even for

259 s, however, the precise function of GPCRs in insecticide resistance remains unclear.

260 s control efforts are hampered by widespread insecticide resistance reported in the Americas and Asia

261 28 were in gene families linked to metabolic insecticide resistance, representing significant enrichm

262 Here, we uncover a mechanism of insecticide resistance resulting from transposon-mediate

263 ow of malaria vectors can help in combatting insecticide resistance spread and planning new vector co

264 As insecticide resistance spreads in Africa, next-generatio

265 den of malaria, information on bionomics and insecticide resistance status of malaria vectors is gros

266 peaks corresponding to genes associated with insecticide resistance such as the voltage gated sodium

267 -seq approach can be applied as a wide-scale insecticide-resistance surveillance technique to better

268 igned to monitor the emergence and spread of insecticide resistance (technical resistance), do not tr

269 identified Anopheles funestus mosquitoes in insecticide resistance tests were found to be other spec

270 ep towards a quantitative genotypic model of insecticide resistance that can be used to predict resis

271 es are now resurgent, largely because of the insecticide resistance that has developed in mosquito ve

272 ed in malarial control is the acquisition of insecticide resistance that has developed in mosquitoes

273 the adaptive genomic changes associated with insecticide resistance that have been characterized to d

274 tifies a previously undescribed mechanism of insecticide resistance that is likely to be highly relev

275 ound that unlike many P450 genes involved in insecticide resistance that were reported previously, CY

276 Due to insecticide resistance, there is an urgent need to devel

277 By identifying novel DNA markers of insecticide resistance, this study opens the way for tra

278 argely on insecticides, but the evolution of insecticide resistance threatens the effectiveness of su

279 nd elimination of vector-borne diseases, but insecticide resistance threatens the efficacy of availab

280 Insecticide resistance threatens the success achieved th

281 However, increasing drug and insecticide resistance threatens the successes made with

282 improve efficacy, an urgent need as emerging insecticide resistance threatens their future.

283 Spread of insecticides resistance threatens the control of malaria

284 tigating the possible association of CN with insecticide resistance, three assays were compared for t

285 Cytochrome P450s are associated with insecticide resistance through overexpression and detoxi

286 pact of Plasmodium infection on the level of insecticide resistance to dichlorodiphenyltrichloroethan

287 udy is a summary of the current level of the insecticide resistance to selected organophosphates, pyr

288 urveys have yet to reveal the development of insecticide resistance to these chemical compounds.

289 permethrin resistant mosquitoes that confer insecticide resistance to unravel the molecular basis of

290 ersal, extreme polyphagy, and development of insecticide resistance, together with human activities,

291 Insecticide resistance was present in all vector populat

292 tand the role of Cyp6a2 and related genes in insecticide resistance, we have isolated and characteriz

293 s which have been previously associated with insecticide resistance were detected: gste2-L119V, vgsc-

294 ological shifts in vector species along with insecticide resistance were likely to have eroded the ef

295 High levels of insecticide resistance were observed for five out of six

296 All interventions caused the emergence of insecticide resistance, which, with the loss of herd imm

297 germanica L.) populations, which differed in insecticide resistance, with either nutritionally rich o

298 However, the emergence of insecticide resistance within mosquito vectors risks jeo

299 legs to identify species, age and cuticular insecticide resistance within the Anopheles gambiae s.l.

300 ng threatened by the emergence and spread of insecticide resistance worldwide.