ライフサイエンスコーパス: insertion mutation

1 del of autism mimicking an autism-associated insertion mutation.

2 in a clinical HIV-1 isolate with the MNR 69 insertion mutation.

3 richia coli, each containing a single random insertion mutation.

4 henotype identical to that of a deletion and insertion mutation.

5 S16 homolog through analysis of a transposon insertion mutation.

6 ing ETS domain of Ehf is disrupted due to an insertion mutation.

7 wever, pcfG was unable to complement an ltrB insertion mutation.

8 ts with the C-deletion than those with the C-insertion mutation.

9 tion of a cryptic splice donor site from the insertion mutation.

10 patients with de-novo Thr790Met and exon 20 insertion mutations.

11 ue predisposition of these two serotypes for insertion mutations.

12 from the phenotypes arising from transposon insertion mutations.

13 issense, nonsense, splice site, and deletion/insertion mutations.

14 a cytoplasmic domain deletion and TM domain insertion mutations.

15 , osimertinib, against EGFR and HER2 exon 20 insertion mutations.

16 n was identified in K14: a heterozygous 1 bp insertion mutation (242insG) upstream of the R125C mutat

17 In merodiploid strains carrying deletion or insertion mutations abolishing the synthesis of AdhE pro

18 The inframe deletion and insertion mutations abrogated the transcriptional activa

19 Insertion mutations affect the frequency and distributio

20 A recessive P-element insertion mutation affecting dU2AF38 causes a reduction

21 Disruption of the rpoS gene by a transposon insertion mutation also prevented acetate-induced acid t

22 entation analysis indicated that a fimI'-kan insertion mutation and a fimI frameshift mutation produc

23 Deletion-insertion mutation and colony immunoblotting confirmed t

24 of segregants are those carrying homozygous insertion mutations and allelic triplications, which hav

25 FLT3 receptor is activated by juxtamembrane insertion mutations and by activation loop point mutatio

26 osons are mobile genetic elements that cause insertion mutations and contribute to genome rearrangeme

27 haracterize novel FGFR2 extracellular domain insertion mutations and demonstrate that they are both o

28 s the expression of Ty1 transposable element insertion mutations and genes whose products are require

29 d patterns in the phenotypic consequences of insertion mutation, and to identify individual mutant li

30 fidelity DNA ligation is required to prevent insertion mutations, and that this may be particularly c

31 The implications of these insertion mutations are discussed.

32 The insertion mutations are in the genes and untranslated re

33 hibitory potency toward EGFR and Her2 exon20 insertion mutations as well as selectivity over wild typ

34 s revealed that gH is relatively tolerant of insertion mutations, as 15 of 22 mutants permitted norma

35 The TREX1 proteins containing R114H and the insertion mutations aspartate at position 201 (D201ins)

36 of exons 2 to 4 of PAX9 revealed a cytosine insertion mutation at nucleotide 793, leading to a prema

37 A T-DNA insertion mutation at this locus impairs root curling, s

38 MMR and LLR repair pathways, we constructed insertion mutations at HIS4 that form loops of varying s

39 To determine whether insertion mutations at Lvis1 affect a known proto-oncoge

40 Insertion mutations at seven sites in the protease gene

41 se H2-deficient cells also exhibit increased insertion mutations at switch junctions, a hallmark of a

42 tigated by characterizing the effects of two insertion mutations at the AtSS3 gene locus.

43 Each insertion mutation bears a unique sequence tag called a

44 at the paired sites, and the introduction of insertion mutations between the sites demonstrated that

45 cytotoxin, but this deletion and several cag insertion mutations blocked induction of synthesis of pr

46 The phenotypic similarity of the two insertion mutations, both of which were cis-acting, sugg

47 marker and correction of a single base pair insertion mutation by gene targeting, and in all cases o

48 etermined that even small inserts can target insertion mutation by this method and that the insertion

49 ffected family members revealed two separate insertion mutations (c.539-540insT and c.948-949insATGGC

50 One of its monogenic causes is an insertion mutation [c.304ins (GCG)(7)] on the X chromoso

51 These experiments demonstrate that, rarely, insertion mutations can develop in the HIV type 1 protea

52 d an increased frequency of transversion and insertion mutations compared to all T/A templates.

53 Deletion and insertion mutations confirmed that the FGL sequence was

54 By isolating nearly all the somatic viral insertion mutations contributing to disease in these str

55 This insertion mutation cosegregated closely with the osm1 ph

56 lation, we found only about one-third of the insertion mutations cosegregated with a mutant phenotype

57 wth; and (iv) the deleterious effects of the insertion mutation depend on the presence of the process

58 pleiotropic recessive Arabidopsis transposon insertion mutation, designated hyponastic leaves (hyl1),

59 A series of alanine insertion mutations designed to interrupt the hydrophobi

60 Insertion mutations display G/C-rich N-nucleotide tracts

61 erived macrophages (BMDMs), we identified an insertion mutation disrupting the H. capsulatum homolog

62 Results show that the deletion and insertion mutations do not significantly change the seco

63 DNA polymerase theta (Poltheta) promotes insertion mutations during alternative end-joining (alt-

64 o new familial cases with novel missense and insertion mutations, each occurring within the T-box dom

65 ruses were constructed by introducing linker insertion mutations either outside the IgG Fc binding do

66 ormed genetic screening for single P-element insertion mutations, enabling us to recover 2500 lethal

67 ne identified by the embryo-defective lethal insertion mutation encodes an RPS16 homolog and has been

68 The hpuA insertion mutation exerted a polar effect, abolishing ex

69 ther oncogenic drivers, such as HER2 exon 20 insertion mutations, for which there are emerging effica

70 Removal of the insertion mutation from this recombinant restored replic

71 he effects of specific EGFR and HER2 exon 20 insertion mutations from NSCLC patients that had clinica

72 Complementation analyses with different insertion mutations further defined and confirmed the se

73 e AI were compound heterozygotes for a novel insertion mutation (g.12946_12947insAGTCAGTACCAGTACTGTGT

74 Insertion mutations generated by REMI have facilitated t

75 s in viral DNA synthesis were induced by the insertion mutation H224, which has been reported to inhi

76 alone, supporting data suggesting that this insertion mutation has polar effects on downstream genes

77 nblocking activity and that all three finger insertion mutations have threefold-decreased sensitivity

78 delta mutants, including suppression of the insertion mutation his4-912 delta.

79 ociated with the beneficial effects of early insertion mutations; however, this expansion later slowe

80 . pertussis mutant, SK6, containing a TnphoA insertion mutation in a Bvg-repressed gene (vrg6) was de

81 First, a transposon insertion mutation in a gene encoding a subunit of hydro

82 An insertion mutation in a putative PG acetylase gene (desi

83 However, the insertion mutation in accF abolished detectable uptake o

84 Homozygous plants carrying a T-DNA insertion mutation in AtSPP, spp-2, could not be recover

85 parallel to bmp signaling, we identified an insertion mutation in bmp4.

86 A nonpolar insertion mutation in C. rodentium espB was constructed

87 icity defect is partially complemented by an insertion mutation in cbrA that also causes overexpressi

88 551 insertion as well as a separate deletion-insertion mutation in cspA decreased the capacity of S.

89 The capacities of isogenic strains with an insertion mutation in emm49; with a deletion mutation in

90 . burgdorferi, we examined the effects of an insertion mutation in flaB on the amounts of proteins en

91 An insertion mutation in gldB was polar on gldC, suggesting

92 A previously described 4-bp insertion mutation in GRN exon 2 comprised the majority

93 an in-frame deletion of cdh and a kanamycin insertion mutation in lpxH, covered by pKJB5.

94 h temperatures, we constructed a chromosomal insertion mutation in lpxP, the structural gene for the

95 Moreover, the virus that contained the insertion mutation in m09 exhibited a titer similar to t

96 In contrast, the virus that contained the insertion mutation in M83 exhibited a titer of at least

97 An insertion mutation in mga (the multigene activator) down

98 NT1 or UIA5 harboring pYDH208 with an insertion mutation in mocC failed to utilize MOP as the

99 A deletion-insertion mutation in msbB, a gene that encodes a lipid

100 d by selecting for the correction of a 16-bp insertion mutation in one of the tk sequences.

101 An insertion mutation in one of these genes, Mx4885, caused

102 A transposon insertion mutation in pgant3 or RNA interference to pgan

103 An insertion mutation in ppk causes a decrease in adaptive

104 An insertion mutation in the abcA gene resulted in cells di

105 eterozygous, exon 37, six-base pair in-frame insertion mutation in the affected patient and aunt but

106 Pase activity, can fully complement a lethal insertion mutation in the ATTOC159 gene.

107 A B. subtilis strain with an insertion mutation in the citB gene was devoid of aconit

108 tification of a long-lived mutant bearing an insertion mutation in the cyclin gene clg1(+).

109 mutations, including a newly isolated T-DNA insertion mutation in the gene encoding the ethylene rec

110 We obtained a recessive insertion mutation in the gene encoding yeast TBP-associ

111 We identified an insertion mutation in the gene Sfn in repeated epilation

112 ssociated with a hypomorphic retroviral-like insertion mutation in the Gria4 gene, encoding one of th

113 An insertion mutation in the hsp16.6 gene resulted in lower

114 Strains harboring an insertion mutation in the lpxL(htrB) gene, which encodes

115 Embryos homozygous for an insertion mutation in the LRP6 gene exhibit developmenta

116 An insertion mutation in the metL gene of Salmonella typhim

117 direct association with a transgene-induced insertion mutation in the mouse.

118 es the transcriptional effects of a Ty delta insertion mutation in the promoter of the HIS4 gene, a p

119 In a murine skin infection model, an insertion mutation in the response regulator gene, trxR,

120 An insertion mutation in the sbo gene also conferred loss o

121 Re-sequencing revealed that a 54-bp insertion mutation in the upstream region of miR-15a-16

122 These sequences contained a two-amino-acid insertion mutation in the Vif gene, which was also obser

123 page was the cause of the original germ-line insertion mutation in this family and that the same mech

124 A P-element insertion mutation in this interval exhibits a similar d

125 rders of magnitude, whereas a strain with an insertion mutation in tolB showed no reduction in CTXphi

126 An insertion mutation in traI abolished the production of A

127 , the implication is that the two-amino-acid insertion mutation in Vif contributes significantly to t

128 A mutant strain having an insertion mutation in vnfY has 10-fold less vnf dinitrog

129 eltaICP4), and in1814, a virus containing an insertion mutation in VP16.

130 A nonpolar chromosomal insertion mutation in wzyPaO11 in P. aeruginosa PA103 co

131 nes, Fgf8, Fgf3 and Fgf4, sustain activating insertion mutations in 10%, 42% and 6% of the tumors, re

132 he fitness effects of hundreds of individual insertion mutations in a panel of yeast strains.

133 -specific mutagenesis system to create short insertion mutations in a region of the gene known to be

134 T-DNA insertion mutations in ACA10, but not in the two other A

135 T-DNA insertion mutations in ADA2b and GCN5 were found to have

136 n cassette which autocatalytically generates insertion mutations in all alleles.

137 e and pathogenesis, we created random TnphoA insertion mutations in an H. ducreyi 35000 library clone

138 ellularly by growth adjacent to strains with insertion mutations in any of the other six xanthomonadi

139 se genes by salt stress was blocked by T-DNA insertion mutations in AtS1P and AtbZIP17.

140 Similar insertion mutations in attR had no significant effect on

141 rimination between wild-type and deletion or insertion mutations in BRCA1 and BRCA2 with CE-based HDA

142 he generation of relatively large (31-codon) insertion mutations in cloned genes.

143 Insertion mutations in crr or ptsI of the phosphoenolpyr

144 We identified three pseudoexon insertion mutations in dystrophinopathy patients, two of

145 This is the first study that documents that insertion mutations in E. chaffeensis that cause attenua

146 we examine the fitness effects of 18 random insertion mutations in E. coli in two resource environme

147 clinical isolate strain V583, we constructed insertion mutations in each of the response regulators.

148 Insertion mutations in EGFR and HER2 both occur at analo

149 Strains carrying combinations of insertion mutations in eight candidate loci were created

150 lements in Escherichia coli produces diverse insertion mutations in either a targeted plasmid or a ch

151 Insertion mutations in Erb-b2 receptor tyrosine kinase 2

152 stablished mouse lines with loss of function insertion mutations in Ero1l and Ero1lb encoding ERO1alp

153 We identified two heterozygous insertion mutations in exon 1 of TNFRSF11A in affected m

154 By comparison, cancers with insertion mutations in exon 20 of either EGFR or HER2 ar

155 Insertion mutations in exon 20 of the epidermal growth f

156 nts with non-small cell lung cancer displays insertion mutations in exon20 in EGFR and Her2 with limi

157 Insertion mutations in frzS caused both vegetative sprea

158 Transposon insertion mutations in Gemin3 are larval lethals and als

159 Predicted insertion mutations in genes of interest can be identifi

160 typified by the accumulation of single base insertion mutations in homonucleotide runs.

161 nic suppressors of axr2-1 or in a screen for insertion mutations in IAA genes.

162 is study, we used sequence substitutions and insertion mutations in lasBp-lacZ fusion plasmids to exp

163 We systematically made deletion and insertion mutations in loop 1 then monitored splicing ac

164 n contrast to htrB, extracts of strains with insertion mutations in msbB are not defective in transfe

165 , we evaluated the spectrum of protease gene insertion mutations in patient isolates and analyzed the

166 Insertion mutations in purG and purI prevent thiamine sy

167 Previously, insertion mutations in rimJ, a gene encoding the N-termi

168 xhibited by DeltabipA strains and identified insertion mutations in rluC.

169 selected as suppressors of Ty or solo delta insertion mutations in Saccharomyces cerevisiae have ide

170 Insertion mutations in sprA and sprB did not significant

171 Construction of hel insertion mutations in strain H. influenzae Rd demonstra

172 Base insertion mutations in the anticodons of two different E

173 Here, we report the effects of T-DNA insertion mutations in the Arabidopsis GGB gene, which e

174 repair of DSBs in plants, we isolated T-DNA insertion mutations in the Arabidopsis homologs of the K

175 Our results indicate that insertion mutations in the cytoplasmic tail of the MuLV

176 terogeneity resulting from gene deletion and insertion mutations in the E. chaffeensis genome.

177 We constructed a large pool of insertion mutations in the env gene and analyzed the fit

178 e, we used transposon IS903phikan to isolate insertion mutations in the flp-1 gene (formerly designat

179 Insertion mutations in the fsr operon affected biofilm f

180 y a single gene in Arabidopsis thaliana, and insertion mutations in the Hsp90C gene are embryo lethal

181 but attempts to isolate similar mutants with insertion mutations in the region downstream of the gdhA

182 T-DNA insertion mutations in the single gene that encodes AtUB

183 The transposons create insertion mutations in the target gene, allowing phenoty

184 All possible combinations of insertion mutations in the three genes encoding the acyl

185 R. meliloti derivatives carrying insertion mutations in this locus displayed an N,N,N',N'

186 cterization demonstrated that the transposon insertion mutations in three of the Cds mutants (SR53, S

187 V. cholerae strains with insertion mutations in tolQ, tolR, or tolA were reduced

188 Insertion mutations in two Vibrio cholerae genes, cya an

189 lt pathogenesis were interrupted by the IVET insertion; mutations in other ipx genes are necessary to

190 Analyses of a series of site-directed IE1 insertion mutations indicated that a helix-loop-helix (H

191 Analysis of a panel of IE1 insertion mutations indicated that disruption of a highl

192 HIS4 expression of his4-912delta, a promoter insertion mutation induced by the Ty1-912 long terminal

193 wild-type levels, while introduction of the insertion mutation into wild-type Vif sequences resulted

194 The high density of insertion mutations into Cre allowed us to identify an u

195 d pair of promoters, we introduced point and insertion mutations into the basal elements of the promo

196 he introduction of inactivating deletion and insertion mutations into the E6 or E7 gene.

197 length have been extended by construction of insertion mutations into the uncF(b) gene adding amino a

198 An insertion mutation introduced into the gene directly dow

199 cesses that are disrupted by point and small-insertion mutations introduced into potyvirus HC-Pro.

200 The insertion mutation is lethal, arresting embryonic develo

201 Interestingly, this p6(Pol) insertion mutation is often selected in viruses with the

202 selected as suppressors of Ty and solo delta insertion mutations is Saccharomyces cerevisiae have ide

203 Deletion or insertion mutations lead to a frameshift that causes mis

204 te mutations, nonsense mutations, and a 1-bp insertion mutation, leading to a frameshift and prematur

205 d phenotype data for thousands of non-lethal insertion mutation lines within a single Arabidopsis tha

206 V-1) thymidine kinase (tk) gene with a 16-bp insertion mutation linked to either a defective HSV-2 tk

207 o of them (N771GY and A767-V769dup) are rare insertion mutations located in exon 20.

208 UV melting experiments confirm that insertion mutations lower mt-tRNA(Ser) melting temperatu

209 Insertion mutations made with Tn10d(T-POP) can cause tet

210 One of the insertion mutations mapped to pseudogene Msed_1517 and e

211 ndings suggest that the analysis of 31-codon insertion mutations may provide a simple approach for ch

212 Mice lacking GlcNAc-TIII due to the insertion mutation Mgat3tmlPst (termed Mgat3neo), exhibi

213 An insertion mutation near the upstream promoter for Parp-e

214 plications containing palindromic frameshift insertion mutations near an HO nuclease recognition site

215 ns on the locus where novel gene deletion or insertion mutations occurred, resulting in the net loss

216 bstitution mutations to complex deletion and insertion mutations occurring in autosomal dominant and

217 A deletion-insertion mutation of 7169 fur resulted in upregulation

218 We have identified a T-DNA insertion mutation of Arabidopsis (ecotype C24), named s

219 An insertion mutation of fldA was constructed and was letha

220 In Delta rppA, an insertion mutation of rppA, the PSII gene transcripts we

221 ense, we isolated a mutant with a transposon insertion mutation of sitA, which encodes the periplasmi

222 An insertion mutation of the sensor-regulator gene eliminat

223 We have tested wild-type 1a and 18 insertion mutations of 1a and found a perfect correlatio

224 These mutations were found to be insertion mutations of different transposable elements w

225 Finger insertion mutations of human immunodeficiency virus type

226 However, a Tn5 Lac insertion mutation, Omega7536, has been isolated which s

227 d the effect of the dipeptide fingers domain insertion mutation on strand transfer activity using two

228 dies measuring the influence of a tolC::Tn10 insertion mutation on the expression of an acrA::lacZ re

229 The effects of the substitution and insertion mutations on termination efficiency at the pyr

230 onformational changes and the effects of the insertion mutations on the kinetics of the transition.

231 We measured the effects of fingers insertion mutations on the misincorporation and excision

232 tes and analyzed the effect of these various insertion mutations on viral phenotypes.

233 Of 14 insertion mutations, only IE1(I425) and IE1(I553) failed

234 We find that an insertion mutation or deletion of HSP104 results in inab

235 by a prion protein (PrP) octapeptide repeat insertion mutation originates from southeast England.

236 Insertion mutations outside of the WD domains were wild

237 not bimolecular activation was disrupted by insertion mutations placed immediately downstream of I44

238 n genomic analyses show higher deletion than insertion mutation rates and stronger purifying selectio

239 ficant increase was observed in deletion and insertion mutation rates but no increase in the overall

240 The G57V and 30:H insertion mutations represent the first CLCN5 mutations

241 the protein's N-terminal region, the alanine insertion mutations S44[A] and K48[A], and the substitut

242 hifts in protein degrees of freedom with the insertion mutations show mutual compensation for the E2-

243 Insertion mutations show that ARABIDOPSIS CRINKLY4 is re

244 Analyses of insertion mutations showed that accA through accE are re

245 ne genes and (2) suppression of Ty and delta-insertion mutations (Spt(-) phenotype).

246 Somatic insertion mutations, such as those caused by the inserti

247 Ba1 transduced five distinctly different insertion mutations, suggesting that transduction was ge

248 Also, the insertion mutation tended towards fixation in commercial

249 There was one insertion mutation that added 12 codons and one missense

250 We also found an insertion mutation that adds another six pairs of CT . A

251 onally, we have identified a pseudoknot loop insertion mutation that appears to point to a genetic in

252 rafish Danio rerio as a site of a retrovirus-insertion mutation that caused severe defects during emb

253 An insertion mutation that disrupted the fliI open reading

254 An insertion mutation that disrupts relA blocks the activat

255 An insertion mutation that disrupts the putative comF-flgM

256 unrelated families, we observed an identical insertion mutation that had occurred in a polycytidine t

257 genesis (STM) to conduct a screen for random insertion mutations that affect colonization in the suck

258 identified a subset of EGFR and HER2 exon 20 insertion mutations that are sensitive to existing coval

259 by isolating bacteriophage MudI1734-induced insertion mutations that blocked the growth-stimulatory

260 Spontaneous insertion mutations that caused hyperexpression of eptA

261 We show by deletion-insertion mutations that ftsL and divIC are dispensable

262 his region, there are two, allelic, lethal P-insertion mutations that identify one of these new trith

263 lfon-m-anisidide] were found with transposon insertion mutations that inactivate any of six T4-encode

264 Eleven were base deletion or insertion mutations that led to a frameshift and, along

265 led to the identification of 174 transposon insertion mutations that mapped to 13 individual genes.

266 In addition, we have isolated insertion mutations that render this organism defective

267 ntitatively the abilities of 134 independent insertion mutations to (i) make stable viral RNA, (ii) a

268 Insertion mutations upstream of the eptA gene or those d

269 The region containing the insertion mutation was cloned, sequenced, and found to c

270 An insertion mutation was constructed in pilEL and introduc

271 An insertion mutation was constructed in the rpoS gene on t

272 . aerogenes was cloned and sequenced, and an insertion mutation was generated and shown to be linked

273 tified, cloned, and sequenced and a deletion/insertion mutation was introduced into M. catarrhalis st

274 ene was cloned and sequenced, a deletion and insertion mutation was introduced into N. gonorrhoeae, a

275 The ratio of deletionrcolon;insertion mutations was 4.1.

276 ction relationships in gB, a panel of linker-insertion mutations was generated throughout the coding

277 Using a panel of espB insertion mutations, we describe two regions on either s

278 Twenty-five dipeptide insertion mutations were classified as permissive for in

279 Insertion mutations were constructed for four hre genes

280 Insertion mutations were constructed in each of the 12 g

281 Substitution, deletion and insertion mutations were corrected with different freque

282 Insertion mutations were found in both genes.

283 In this study, a total of 28 linker insertion mutations were generated throughout the length

284 Insertion mutations were identified in genes that are re

285 Insertion mutations were introduced into depA, depB, pha

286 in the stress tolerance of S. mutans UA159, insertion mutations were introduced into the genes encod

287 Insertion mutations were isolated in cya and crp of Yers

288 cy to T790M and S768N mutations, the exon 20 insertion mutations were sensitive to PF00299804.

289 the mutants bearing the D67N and K70R or 69 insertion mutations, whereas the Q151M mutation seems in

290 utant B. subtilis strain carrying a deletion-insertion mutation which removed the entire splAB operon

291 This insertion mutation, which segregates in a dominant manne

292 EGFR exon 20 insertion mutations, which are typically located after t

293 In conclusion, our results identify a novel insertion mutation with altered membrane tethering activ

294 y genes essential for A motility, transposon insertion mutations with defective A motility were studi

295 son has been constructed and used to isolate insertion mutations with tetracycline-conditional phenot

296 A double-guanine-insertion mutation within a run of guanines in the herpe

297 We have identified a deletion/insertion mutation within exon D of the human biotinidas

298 ast to iscS or hscA, a strain having a polar insertion mutation within the cysE-like gene was readily

299 Specific lysine insertion mutations within Acm1 promoted its ubiquitinat

300 Attempts to place non-polar insertion mutations within either A. vinelandii iscS or