ライフサイエンスコーパス: insertion-deletion

1 diverse set of genetic changes (mismatches, insertions, deletions).

2 single-nucleotide polymorphisms and an 11-bp insertion-deletion.

3 sign integer weights for match, mismatch and insertion/deletion.

4 matic mutation, isotype switching, and codon insertion/deletion.

5 ts and creates translatable mRNAs by uridine insertion/deletion.

6 , which must be remodeled to promote uridine insertion/deletion.

7 rising multiple nearby base substitutions or insertion-deletions.

8 ns allowing for diversity of recognition via insertion/deletions.

9 small +1 insertion/deletions than larger +4 insertion/deletions.

10 onventional PCRs directed at 11 SNPs and two insertion/deletions.

11 e sequencing to identify repeat elements and insertion/deletions.

12 leotide variants and enable scoring of short insertions-deletions.

13 se substitutions, strand slippage, and small insertions/deletions.

14 mal rearrangement of syntenic blocks and DNA insertions/deletions.

15 le-nucleotide variants (SNVs) or single-base insertions/deletions, 3 siblings harbored a heterozygous

16 Core editing complexes and their U-insertion/deletion activities are relatively well charac

17 20 missense/nonsense mutations as well as 60 insertions/deletions affecting 73 different genes ( appr

18 n important role for rs2004640 and the CGGGG insertion/deletion, along with type I IFNs, in regulatin

19 ated approach combining mutation profile and insertion/deletion analyses, we identified nine novel li

20 nome-wide copy number analysis identified 51 insertion deletions and 440 copy number variants > 1 kb.

21 copy number variation (CNV) which comprises insertion, deletion and duplication of genomic sequence,

22 ntly formed in living cells due to erroneous insertion, deletion and misincorporation of bases.

23 nments allowing up to three errors including insertion, deletion and mismatch.

24 inear space and supports quasi-constant time insertion, deletion and movement (i.e. updates) of atoms

25 nables researchers to additionally determine insertion, deletion and recombination events as well as

26 tain robust maximum-likelihood estimates for insertion, deletion and substitution error rates (4.9%,

27 onserved regions exhibiting reduced rates of insertion, deletion and substitution mutations.

28 uence to the another using the substitution, insertion, deletion and transposition operations.

29 rmissible edit operations are: substitution, insertion, deletion and transposition.

30 accurate and efficient multiplexing of small insertion-deletions and single-nucleotide variants chara

31 Recently, somatic substitution, insertion/deletion and rearrangement patterns, or 'mutat

32 Insertion/deletion and single nucleotide polymorphisms a

33 Finally, we model both insertion/deletion and substitution sequencing errors us

34 nd recruited Mlh1-Pms1 on +1, +2, +3, and +4 insertion/deletions and CC, AA, and possibly GG mispairs

35 Third, insertion/deletions and repeat elements identified in th

36 mostly the mmu-let-7 family display internal insertion/deletions and substitutions when compared to p

37 the effects of multiple mutations, including insertions, deletions and alternative splicing events, i

38 usion partners), single nucleotide variants, insertions, deletions and copy number changes.

39 accumulates unbalanced rearrangements (novel insertions, deletions and duplications) more rapidly.

40 luding not only rearrangements but also gene insertions, deletions and duplications.

41 nges including gene and genome duplications, insertions, deletions and gene order rearrangements.

42 ta, such as single nucleotide polymorphisms, insertions, deletions and genome-wide association studie

43 generation data to quantify and characterize insertions, deletions and homologous recombination.

44 ation on an intermediate scale--particularly insertions, deletions and inversions affecting from a fe

45 Structural variants, including duplications, insertions, deletions and inversions of large blocks of

46 etect SV and characterize a total of 220,452 insertions, deletions and inversions.

47 nces between sequences reflect the impact of insertions, deletions and mutations.

48 l variation, including copy number variants, insertions, deletions and other structural variants (SVs

49 tations, including amino acid substitutions, insertions, deletions and point mutations.

50 arget cleavage resulted in a wide variety of insertions, deletions and point mutations.

51 e major cartilage collagen gene COL2A1, with insertions, deletions and rearrangements identified in 3

52 cting relatively simple types of SVs such as insertions, deletions and short inversions.

53 storing DNA polymorphism data such as SNPs, insertions, deletions and structural variants, together

54 op SEQuel, a tool that corrects errors (i.e. insertions, deletions and substitution errors) in the as

55 ng the edit-distance (i.e. minimum number of insertions, deletions and substitutions) between short D

56 genome assembly, and make over 800 changes (insertions, deletions and substitutions) to refine this

57 and knock-ins, as well as single-nucleotide insertions, deletions and substitutions, in Pseudomonas

58 L979F Pol zeta in vitro include single-base insertions, deletions and substitutions, with the highes

59 vely, which recognize base-base mispairs and insertions/deletions and initiate the repair process.

60 Differential gene amplification, insertions/deletions and inversions appeared to be the c

61 difficulty in assessing the impact of small insertions/deletions and large structural variants.

62 ainst a reference genome to call SNPs, short insertions/deletions and structural variations.

63 e polymorphisms, simple sequence repeats and insertion/deletions) and location (exon and intron seque

64 variations (single nucleotide variations and insertion/deletions) and to help guide and summarize gen

65 a simple and versatile method for generating insertion, deletion, and point mutations on chromosomal,

66 on to precise excision, several "suppressor" insertion, deletion, and point mutations restore the wil

67 Molecular editing such as insertion, deletion, and single atom exchange in highly

68 ntinuous-time Markov chain model composed of insertion, deletion, and substitution events.

69 atasets, for all kinds of sequencing errors (insertion, deletion, and substitution), and for high and

70 ally validated all loss-of-function, inframe insertion/deletion, and missense variants predicted as d

71 s include >35,000 point mutations, 446 small insertion/deletions, and >6,000 genes affected by copy n

72 175 edits in human cells, including targeted insertions, deletions, and all 12 types of point mutatio

73 tural aberrations, including translocations, insertions, deletions, and complex reassembly through ch

74 e TGF-beta superfamily is dictated by unique insertions, deletions, and disulfide bonds rather than a

75 We sequence resolved 99,604 insertions, deletions, and inversions including 2,238 (1

76 Insertions, deletions, and residue-to-residue mutations

77 repairs all three basic types of DNA errors: insertions, deletions, and substitutions.

78 om no response, to high levels of mutations, insertions, deletions, and truncations.

79 ite instability, increased number of somatic insertions/deletions, and altered mutation signatures in

80 Most mutations, small insertions/deletions, and copy number alterations detect

81 t increases in base substitutions, small DNA insertions/deletions, and gross chromosomal rearrangemen

82 outcome, whereas missense, splice site, and insertion/deletions are less reliably associated with ag

83 Single base substitutions (SBSs) and insertions/deletions are critical for generating populat

84 Primer sequences flanking polymorphic insertions/deletions are produced as output.

85 Although insertions/deletions are thought to be rare in microbial

86 ch is robust to the type of error (mismatch, insertion, deletion), as well as to the relative abundan

87 Deleted alleles also typically include small insertion/deletions at predicted deletion junctions.

88 The number of SNPs and insertions/deletions between sequences of the two Montan

89 ximately 98% of differences (including large insertion-deletions) between pairs of strains from three

90 rating a broader range of variations such as insertions/deletions, block substitutions, IUPAC codes s

91 accurate estimates on gene gains/losses (or insertions/deletions), but also reduces any concern of a

92 the recognition of base-base mismatches and insertions/deletions by bacterial MutS or eukaryotic MSH

93 tform that detects nucleotide substitutions, insertions/deletions, chromosomal translocations, copy n

94 qual in frequency to deletions, and compound insertion-deletions comprised only 0.1% of all events.

95 help to identify single nucleotide variants, insertions/deletions, copy number variations, and transl

96 7:H7 serotype based on a conserved signature insertion/deletion (CSI) located in the ybiX gene using

97 identify a series of novel set of mid-range insertion/deletion detection that were confirmed by targ

98 that has mainly been used for point or small insertion/deletion detection.

99 al analysis revealed a predominance of small insertion/deletion, duplication, and base substitution m

100 omirskiidae mitochondrial genomes are due to insertion/deletion/duplication of these elements rather

101 numts, we quantified the frequency of small insertions, deletions, duplications, and instances of mi

102 to identify genomic rearrangements, such as insertions, deletions, duplications, and inversions, com

103 tically compromised their ability to perform insertion/deletion editing and thereby generate mature f

104 A editing core complex (RECC) catalyze the U-insertion/deletion editing cascade to generate open read

105 alled the editosome, which is required for U-insertion/deletion editing of mitochondrial mRNAs.

106 gen, most mRNAs are internally modified by U-insertion/deletion editing while guide RNAs and rRNAs ar

107 RNAs proceed through 3' adenylation, uridine insertion/deletion editing, and 3' A/U-tailing.

108 ochondrial pre-mRNAs undergo massive uridine insertion/deletion editing, which creates open reading f

109 ion, 5' pyrophosphate removal, and, often, U-insertion/deletion editing.

110 or specificity that is highly biased towards insertion-deletion errors.

111 guishes length variants from noise including insertion/deletion errors in homopolymer runs by address

112 ated from one another by only 49 SNPs and 11 insertion-deletion events (indels) in the core genome.

113 single nucleotide variants (SNVs) and 79,529 insertion-deletion events that result in a total of 3.3

114 y of de novo copy number variants (CNVs) and insertion/deletion events (indels) is significantly elev

115 ingle nucleotide polymorphisms (SNPs) and 86 insertion/deletion events (indels).

116 Comparison of nucleotide substitution and insertion/deletion events among different P. micropora s

117 More than one-third of the insertion/deletion events occurred in genic regions, and

118 emonstrate SLOPE's ability to rapidly detect insertion/deletion events of various sizes as well as tr

119 million rare single-nucleotide variants and insertion/deletion events, of which ~176,000 are predict

120 t a nearby single nucleotide polymorphism or insertion/deletion (false discovery rate = 10%).

121 entrocyte subtype had high TP53 mutation and insertion/deletion frequencies and expressed LMO2, CD58,

122 ytical results for point mutations and small insertions/deletions from 3,281 tumours across 12 tumour

123 Frameshift insertion/deletions (fs-indels) are an infrequent but hi

124 ic assemblies, including single-base errors, insertions/deletions, genome rearrangements and chimeric

125 number variations, mRNA and genomic SNP and insertion-deletion genotypes, or the expression of appro

126 and off-target read detection and quantifies insertions, deletions, HDR repair, as well as targeted b

127 MutSbeta (MSH2-MSH3) mediates repair of insertion-deletion heterologies but also triggers triple

128 (-675 4G/5G deletion/insertion) and tPA (Alu insertion/deletion [I/D]), are associated with strokes,

129 t preferentially process base-base and small insertion/deletion (ID) mispairs, respectively, despite

130 million single-nucleotide polymorphisms and insertions/deletions identified by whole-genome sequenci

131 recognition of DNA mismatches or nucleotide insertions/deletions (IDLs) by MutS and MutS homologues.

132 d with ADCME by identifying a novel in-frame insertion/deletion in 2 Italian families.

133 e relied on frameshifts caused by stochastic insertion/deletion in all alleles.

134 One novel SNP and a novel insertion/deletion in CAV2 were identified; rs13221869 i

135 ariant that contains a recently evolved KGKY insertion/deletion in the third intracellular loop (ICL3

136 gonococcal MMC repairs mismatches and small insertion/deletions in DNA and also affects the recombin

137 of these fast evolving effectors through (i) insertion/deletions in loop regions between alpha-helice

138 The presence of insertion/deletions in promoters often influences the pr

139 s is suggested by the high prevalence of TTN insertion/deletions in the 1000 Genomes Project cohort.

140 The gene CDKN1B is inactivated by small insertions/deletions in 8% of patients with SI-NET sugge

141 ch repair corrects mispaired bases and small insertions/deletions in DNA.

142 s and by eight to 22 SNPs and 10 to 21 short insertions/deletions in noncoding regions.

143 sis revealed four nonsynonymous SNPs and two insertions/deletions in the susceptible allele of Las2,

144 A and C to G/G to C transversions) and small insertions/deletions (in/dels).

145 variants (single nucleotide polymorphisms or insertions/deletions) in the ADAMTS13 gene.

146 icularly associated with the accumulation of insertion-deletion (indel) mutational load.

147 slippage is a structural mechanism by which insertion-deletion (indel) mutations are introduced duri

148 The R genes tested to date segregate for insertion-deletion (indel) polymorphisms where susceptib

149 e the value of our approach by examining the insertion-deletion (indel) process in the enolase gene a

150 ence dissimilarity corresponds with the fast insertion-deletion (indel) rates observed in short monon

151 we show that each of 12 base substitution, 2 insertion/deletion (indel) and 6 rearrangement mutationa

152 nymous changes per gene and more than 16,000 insertion/deletion (indel) and copy number changes, prov

153 ective single-nucleotide polymorphism (SNP), insertion/deletion (INDEL) and copy number variation (CN

154 otgun sequencing (WGS) data, such as SNP and insertion/deletion (INDEL) calling, can also be achieved

155 report a phylogenetic analysis of genomewide insertion/deletion (indel) data, an approach conventiona

156 Relative polymerase accuracy for insertion/deletion (indel) errors within 2-3 unit repeat

157 ukaryotic cells, resulting in frame-shifting insertion/deletion (indel) mutations and subsequent prot

158 Rates for insertion/deletion (indel) mutations have been found to

159 SNPs by imputation P-value revealed a 30 bp insertion/deletion (indel) variant that was significantl

160 single-nucleotide variants (SNVs) and short insertion/deletion (indel) variants from deep whole-geno

161 atalog of millions of single nucleotides and insertion/deletion (INDEL) variants of the human populat

162 s), which mainly differ in one 18-nucleotide insertion/deletion (indel).

163 le-nucleotide substitutions (SNP/SNV), short insertions/deletions (INDEL) and structural variants/cop

164 es in relative frequency of transversion and insertion/deletion [indel] mutations).

165 impact on specific mutational classes (e.g., insertion/deletion [indel] vs. single nucleotide variant

166 The introduction of insertion-deletions (INDELs) by non-homologous end-joini

167 ide variety of structural variants including insertion-deletions (indels), inversions and translocati

168 y single nucleotide polymorphisms (SNPs) and insertion-deletions (indels), perform SNP annotations an

169 landscape of quiescence is characterized by insertion/deletion (indels) accumulating as fast as sing

170 tect single nucleotide polymorphisms (SNPs), insertion/deletions (indels) by comparing high-throughpu

171 eotide polymorphisms (SNPs) and 48 single-nt insertion/deletions (indels) from the data set.

172 en single nucleotide variations (SNVs) and 2 insertion/deletions (INDELs) were identified; these muta

173 We found 20 million SNPs and 1.5 million insertions-deletions (indels).

174 , single-nucleotide polymorphisms (SNPs) and insertions/deletions (indels) can result in altered on-t

175 single-nucleotide variants (SNVs) and small insertions/deletions (indels) detected per sample were 8

176 Reliable identification of expressed somatic insertions/deletions (indels) is an unmet need due to ar

177 Small insertions/deletions (INDELs) of </=21 bp comprise 18% o

178 We obtained a listing of all SNPs and insertions/deletions (indels) present in SPRET/Ei from t

179 amage, often result in unintended nucleotide insertions/deletions (indels) via mutagenic nonhomologou

180 ingle nucleotide polymorphisms (SNPs) and 25 insertions/deletions (indels) were detected in HvP5CS1 a

181 such as single-nucleotide polymorphisms and insertions/deletions (indels), and by sequencer errors m

182 tologic malignancies includes substitutions, insertions/deletions (indels), copy number alterations (

183 er, single-nucleotide variants (SNVs), small insertions/deletions (indels), copy-number variants (CNV

184 le single-nucleotide variants (SNVs), simple insertions/deletions (indels), multiple-nucleotide varia

185 rently composed of base substitutions, small insertions/deletions (InDels), structural variants, and/

186 orphisms (SNPs), 58,085 small and 2315 large insertions/deletions (indels), with highly correlated ge

187 mall nucleotide polymorphisms (SNPs) and 172 insertions/deletions (indels).

188 ue for single nucleotide variants (SNVs) and insertions/deletions (indels).

189 ave predicted 4314 GRs including large-scale insertions, deletions, inversions and translocations bas

190 ble misaligned sequence reads for predicting insertions, deletions, inversions, tandem duplications a

191 eral thousand single nucleotide variants and insertions/deletions, it remains a challenge to analyze

192 ed mutations such as substitutions and small insertion/deletions, large structural alterations and co

193 y model with an empirically common power-law insertion/deletion length distribution.

194 te that, following the recognition of a 3-bp insertion-deletion loop mismatch, the MMR machinery sear

195 roduplex, containing either a mismatch or an insertion/deletion loop of up to four nucleotides.

196 cleotides whereas MutSbeta recognizes longer insertion-deletion loops (IDLs) with 1 to 15 unpaired nu

197 In Saccharomyces cerevisiae, repair of insertion/deletion loops is carried out by Msh2-Msh3-med

198 s in MMR, Msh2-Msh6 binds mispairs and small insertion/deletion loops, and Msh2-Msh3 binds larger ins

199 n/deletion loops, and Msh2-Msh3 binds larger insertion/deletion loops.

200 variation at 1327 nuclear microsatellite and insertion/deletion markers.

201 homozygosity (TOH), repetitive elements, and insertion/deletions, may provide a comprehensive underst

202 four or more single nucleotide mismatches or insertion/deletion mismatches, as compared with the huma

203 of the 8 possible base:base mispairs, the +1 insertion/deletion mispair, and to a low level on the +2

204 o a low level on the +2 but not the +3 or +4 insertion/deletion mispairs and not on the CC mispair.

205 Thus, recognition of small insertion/deletion mispairs by Msh3 appears to require a

206 with the DNA conformations induced by small insertion/deletion mispairs than with those induced by l

207 ed defects in repair of both small and large insertion/deletion mispairs, whereas the second class ca

208 s caused defects only in the repair of small insertion/deletion mispairs; mutations of the first clas

209 onary models compatible with the affine-cost insertion/deletion model used in standard pairwise seque

210 This paper discusses progress in the area of insertion-deletion models, in view of recent work by Eza

211 Here, we review the mechanism of uridine insertion/deletion mRNA editing in kinetoplastid protist

212 However, guide RNAs (gRNAs) that direct U-insertion/deletion mRNA editing in mitochondria of trypa

213 t-transcriptionally and requires extensive U-insertion/deletion mRNA editing.

214 Aside from nucleotide substitutions and insertion/deletions, multiple IS6110 transposition event

215 Analysis of a slr1270 insertion deletion mutant and respective wild-type revea

216 Microarray analyses indicated that insertion/deletion mutants in spd-sr37 and ccnA exerted

217 Patients with KIT exon 11 deletion or insertion-deletion mutation had better RFS when allocate

218 Each gene has a coding sequence insertion/deletion mutation within the SC species that p

219 rozygous for a GAA expansion and a FXN point/insertion/deletion mutation.

220 The insertion-deletion mutations may play an important role

221 utations were further grouped as deletion or insertion-deletion mutations, substitution mutations, in

222 Spontaneously arising and MMS-induced insertion/deletion mutations and large rearrangements we

223 identified heterozygous missense or in-frame insertion/deletion mutations in C1R (15 families) or C1S

224 Four discrete insertion/deletion mutations leading to frame shifts and

225 BRCA1 null breast tumors, there are specific insertion/deletion mutations located close to R-loop-med

226 were heterozygous missense or small in-frame insertion/deletion mutations occurring within one of the

227 We recently identified 2 patients with novel insertion/deletion mutations predicted to result in mRNA

228 nonymous single nucleotide polymorphisms and insertion/deletion mutations when our Weiss (n = 4) and

229 g-based detection confirmed specific genomic insertion/deletion mutations with 99.5% penetrance in so

230 contained 82 intraspecific substitution and insertion/deletion mutations, and provided evidence for

231 e also found that RNF8 suppresses EJ without insertion/deletion mutations, which is a hallmark of C-N

232 letion rearrangement and end joining without insertion/deletion mutations.

233 g schemes in mouse embryos, including indel (insertion/deletion) mutations, point mutations, large de

234 ct the genome in a variety of ways, creating insertions, deletions, new splice sites or gene expressi

235 Using hidden Markov models on insertion, deletion, nucleotide substitution, and micros

236 SBSs and insertions/deletions occur predominantly at the first an

237 Multiple substitutions and insertions/deletions of the nucleotide bases in the sequ

238 ) of the new model reveal fast rates of gene insertions/deletions on recent branches, suggesting a fa

239 end-joining (NHEJ) resulting in nonspecific insertions, deletions or other mutations (indels).

240 tructures emerge in evolution as a result of insertions, deletions or shuffling of fragments of under

241 an promote efficient introduction of desired insertions, deletions or substitutions at or near the cu

242 typic and genotypic tests were attributed to insertions/deletions or point mutations identified in O-

243 sent single nucleotide polymorphisms but are insertions/deletions originating from DNA replication sl

244 Ninety-nine tagSNPs and one tag insertion-deletion polymorphism were sufficient to predi

245 The frequent ACE insertion/deletion polymorphism (I/D) is, albeit inconsi

246 tudy tested the hypothesis that the ACE gene insertion/deletion polymorphism associates with AF recur

247 We demonstrate that a MIR148A insertion/deletion polymorphism associates with its own

248 In 1990, we identified an insertion/deletion polymorphism in ACE that functions as

249 T-2) gene variants rs3217318, a 19-base-pair insertion/deletion polymorphism in the promoter region,

250 Within this genomic interval, an insertion/deletion polymorphism of 36 bp in the coding r

251 xysmal (59%) or persistent (41%) AF, the ACE insertion/deletion polymorphism was genotyped using poly

252 rs111200466 is a TLR2 promoter insertion/deletion polymorphism with contradictory data

253 ells expressing TRBV4-3 because of a 21.5-kb insertion/deletion polymorphism, but these individuals r

254 ts derived from short tandem repeats (STRs), insertion deletion polymorphisms (indels) and single nuc

255 single nucleotide variants (SNVs) and 50,000 insertion-deletion polymorphisms (indels) for associatio

256 e single-nucleotide polymorphisms (SNPs) and insertion-deletion polymorphisms (indels) within bovine

257 orphisms (SNPs) or approximately 0.2 million insertion-deletion polymorphisms.

258 000 is determined by coding, regulatory, and insertion/deletion polymorphisms at five chromosomal loc

259 We report here that small insertion/deletion polymorphisms in the promoter and 5'

260 escape was associated with substitutions and insertion/deletion polymorphisms in the V1 and V4 domain

261 p populations revealed that neither the IRGM insertion/deletion polymorphisms nor the CNV was associa

262 nsynonymous single nucleotide polymorphisms, insertion/deletion polymorphisms, or splice site alterin

263 ts included single-nucleotide polymorphisms, insertions/deletions, polynucleotide tracts, and differe

264 heless often edited with inversions or small insertion/deletions produced at CRISPR recognition sites

265 produces full atomic level models (including insertion/deletion regions) of protein complexes as long

266 coverage included 218 of 247 SNPs, 10 of 11 insertion/deletion regions, and the repeat elements IS10

267 Uridine insertion/deletion RNA editing in kinetoplastid mitochon

268 U-insertion/deletion RNA editing in the single mitochondri

269 Uridine insertion/deletion RNA editing is a unique form of postt

270 Uridine insertion/deletion RNA editing is an essential process i

271 ub-Saharan Africa, depends on a remarkable U-insertion/deletion RNA editing process in its mitochondr

272 UTase 2 (RET2) play central roles in uridine insertion/deletion RNA editing, which is an essential pa

273 imple extension of the general "substitution/insertion/deletion (SID) model".

274 ernative methods for all cloning procedures (insertions, deletions, site-directed mutagenesis and sub

275 The GCMC water insertion/deletion steps were alternated with Molecular

276 A alignment, including alternative splicing, insertions, deletions, substitutions, sequencing errors

277 notate single nucleotide variants (SNVs) and insertions/deletions, such as examining their functional

278 ore critical for the recognition of small +1 insertion/deletions than larger +4 insertion/deletions.

279 on mispairs than with those induced by large insertion/deletions that are intrinsically bent and stra

280 e most desired mutations, i.e., out-of-frame insertions/deletions that disrupt genes.

281 , disrupt canonical splice sites, or lead to insertions/deletions that shift frame.

282 lve subtle nucleotide substitutions (but not insertions/deletions) that exist between intragenomic co

283 derived from the sequence alignment without insertions/deletions, the outer carboxylates did not fac

284 are variants and more complex variants (e.g. insertions, deletions), their role in disease is as yet

285 Plastid-LCGbase facilitates gene variation (insertion-deletion, translocation and rearrangement) and

286 tion of mRNAs that require extensive uridine insertion/deletion (U-indel) editing for their maturatio

287 The causal variant was identified: an insertion-deletion variant, GCTGT-->A (in which A is the

288 esults were obtained for 10,641,224 SNPs and insertion-deletion variants with minor allele frequencie

289 enetic variants (99%-100%) but low for small insertion/deletion variants (53%-59%).

290 ed a strong enrichment of very low-frequency insertion/deletion variants, so far under-investigated,

291 30 single-nucleotide polymorphisms and four insertion/deletion variants.

292 the functional effects of non-frameshifting insertion/deletion variants.

293 ified for single nucleotide polymorphism and insertion-deletion variation.

294 ional residues impacted by non-frameshifting insertion/deletion variation.

295 ws biologists to discover potential point or insertion-deletion variations from cDNA-genome alignment

296 40, rs10954213, and rs10488631 and the CGGGG insertion/deletion were genotyped in these patients.

297 ssense, predicted splice site mutations, and insertion/deletions were classified as "other." We compa

298 single nucleotide polymorphisms, as well as insertions/deletions which can be used to rapidly develo

299 calcium channels aligned with NavAb without insertions/deletions, which suggests that NavAb is a pro

300 ong these, 70% are nonsense, splice site, or insertions/deletions with frameshift for which no domina