ライフサイエンスコーパス: instability

1 es core fragility regions leading to genomic instability.

2 omic scars associated with pathogenic genome instability.

3 es for the precise analysis of their genetic instability.

4 in state interact and thereby promote repeat instability.

5 ble for both the film collapse and wrinkling instability.

6 heckpoint, resulting in profound chromosomal instability.

7 V status, tumour hypoxia, and microsatellite instability.

8 riant of MMS21 associated with increased 2mu instability.

9 /-) mice showed increased features of plaque instability.

10 anding of mechanisms underlying human genome instability.

11 shape the structure through a barreling-type instability.

12 mechanism of adhesion hysteresis and dynamic instability.

13 n transcription, telomere biology and genome instability.

14 including their heterogeneity and functional instability.

15 IS G1 (~2.63 Ma) are also suggestive of EAIS instability.

16 commonly observed as a result of mechanical instability.

17 n stall replication forks, leading to genome instability.

18 how, when unresolved, they can cause genome instability.

19 ond below threshold strain levels for phonon instability.

20 poor tumor cellularity and extensive genomic instability.

21 mechanisms by which MoTeRs promote telomere instability.

22 rge-scale chromatin structure and chromosome instability.

23 of these structures is at the core of repeat instability.

24 he photovoltage and introduces morphological instability.

25 rtial collapse owing to the marine ice-sheet instability.

26 ination events leading to rampant chromosome instability.

27 iant imparts reduced activity due to protein instability.

28 A replication stress and may promote genomic instability.

29 this correlates with aneuploidy and genetic instability.

30 absence of RER induces mutations and genome instability.

31 d DNA) create DNA damage and lead to genomic instability.

32 oth chaperones, perhaps due to misfolding or instability.

33 ion stress, double-strand break, and genomic instability.

34 eakup into droplets via the Rayleigh-Plateau instability.

35 cation stress-induced DNA damage and genomic instability.

36 and the tissue specificity of somatic repeat instability.

37 metal, on the verge of an antiferromagnetic instability.

38 therapeutic agent aims to reduce CAG repeat instability.

39 , tissues and gene sets contributing to mood instability.

40 senting a mechanism of Z-DNA-induced genomic instability.

41 inhibitors in cancers without microsatellite instability.

42 rowth is limited by a size-dependent dynamic instability.

43 types of hyperexcitability and physiological instability.

44 ation of micronuclei, a clear sign of genome instability.

45 e computational model of microtubule dynamic instability.

46 st evidence of incompetence, immorality, and instability.

47 ree quercetin, which points to their thermal instability.

48 can also contribute to DNA damage and genome instability.

49 es that are further linked to microsatellite instability.

50 that produces gene amplification and genome instability.

51 s importance for magma transport and volcano instability.

52 red by issues of colloidal and photophysical instability.

53 elicoidal texture is stabilized by competing instabilities.

54 embedded imperfections to directly simulate instabilities.

55 nd is associated with high levels of genomic instability(4-6).

56 severe injuries (mean ISS = 23; hemodynamic instability = 70%; hospital/ICU stay = 12 d; mortality =

57 etions, making them a major cause of genomic instability, a driving force of many diseases of civiliz

58 ments during mitosis can lead to chromosomal instability, a hallmark of human cancers.

59 endency and bias stress effects on electrode instability, a parameter often overlooked in electrochem

60 In contrast, we discovered that chromosomal instability activates cGAS/STING signaling but strongly

61 We suggest that hydrodynamic instabilities adjust the angular-momentum distribution a

62 mors establishes the frequency of GBM driver instability after chemoradiotherapy with temozolomide.

63 umented in early UC, contributing to genetic instability, altered gene expression and tumor progressi

64 gered activity in vivo and of repolarization instability amplifying the substrate for re-entry.

65 pled map lattice model reveal the underlying instabilities and bifurcations for the genesis, selectio

66 state in Sm-Co magnets results from curling instabilities and domain-wall pinning effects at the int

67 s via shear dispersion, generated by frontal instabilities and episodic vertical mixing.

68 and its targeted deletion induces centromere instability and abnormal chromosome segregation.

69 th restriction of cell proliferation, genome instability and aging.

70 components, resulting in protein and complex instability and altered expression and/or activities of

71 human colorectal cancers with microsatellite instability and as a predictive indicator of small cell

72 nitially flat but later undergo a mechanical instability and become wrinkled.

73 Solution instability and biochemical heterogeneity of 10E8 has ha

74 little is known about its impact on genomic instability and cancer immunity.

75 R sub-pathways, with implications for genome instability and cancer.

76 -crystal materials exhibit severe structural instability and capacity fade.

77 n lead to chromosome rearrangements, genomic instability and cell death.

78 androgen receptor signaling inducing genome instability and changing DNA repair capacity in prostate

79 rameterizations have been prone to issues of instability and climate drift, and their performance for

80 sis to elucidate the interplay between fluid instability and crystallization kinetics that determines

81 of collectors results in early onset of SEI instability and dendrites.

82 harboring hibernating ribosomes restores Mrf instability and dissociates Mpy from the ribosome.

83 nd sodium modelling may prevent haemodynamic instability and facilitate large volumes of fluid remova

84 We investigated the molecular origin of the instability and found that the diseased lipid membrane h

85 an be used to study the evolution of genetic instability and infer tumor evolutionary history from ex

86 reprogram energy metabolism, induce genomic instability and inflammation, and trigger evasion of imm

87 nadaene's toxic activity are hindered by its instability and insolubility in purified form.

88 iR-31(-/-) rat esophagus displayed no genome instability and limited metabolic activity changes vs. t

89 In the experiments, we detect instability and localize its source, implement drift con

90 f charged droplets by control of Taylor cone instability and micro-electric field, enables the creati

91 omplete MiDAS at FRAXA leads to severe locus instability and missegregation in mitosis.

92 al R-loops and DNA damage leading to genomic instability and neurodegeneration in SMA.

93 onal R-loops and DNA damage to avert genomic instability and neurodegeneration in SMA.

94 mutants also reveals a degree of progressive instability and neurodegeneration that was not apparent

95 Though not mutually exclusive, chromosomal instability and pathogenic variants affecting the long a

96 ighly toxic lesion that leads to chromosomal instability and perturbs normal transcription.

97 agents in particular are notorious for their instability and poor reactivity in Suzuki-Miyaura cross-

98 , SET2, PBRM1 and BAP1, may engender genomic instability and promote defects in DNA repair pathways.

99 In addition to chromosomal instability and replication stress, Gcna mutants accumul

100 approaches to helping the patient's cervical instability and resulting 'head-drop' had previously fai

101 Instability and state anxiety were greater in patients t

102 ify additional driver mechanisms for genomic instability and targeted strategies to exploit these def

103 cts in DNA replication contribute to genomic instability and the diverse differentiation potentials o

104 for gender bias in intergenerational repeat instability and the tissue specificity of somatic repeat

105 g7-deficient Lgr5(+)ISC but promotes genetic instability and tumor formation.

106 IP function is sufficient to trigger genomic instability and tumorigenesis, complete deletion of BCCI

107 P function was sufficient to trigger genomic instability and tumorigenesis.

108 to synthesize primers, likely due to protein instability and weakened DNA binding.

109 Cells depleted for BGL3 displayed genomic instability and were sensitive to DNA-damaging reagents.

110 al role in protecting against microsatellite instability and while MLH3 does have an associated endon

111 Tumor testing for microsatellite instability and/or mismatch repair-deficiency (MSI/IHC)

112 To avoid process instability and/or reactor failure, two metrics had to b

113 d at researchers, to test their networks for instabilities, and for government agencies, such as the

114 rative fold, higher flexibility, and kinetic instability, and a higher dynamic state in its native fo

115 the linear response, the onset of mechanical instability, and aspects of the postinstability state.

116 ong magnetic fields characteristic of Weibel Instability, and corroborated the relativistic radial ex

117 tice-matched, show no detrimental electronic instability, and display broken type-III gap, thus offer

118 omal recessive immunodeficiency, centromeric instability, and facial anomalies (ICF) syndrome is a ge

119 iethylnitrosamine-induced DNA damage, genome instability, and further tumorigenesis so that LRPPRC kn

120 tractility, which is required to trigger the instability, and illustrate how the wavelength of the in

121 h as embrittlement, accelerated creep, phase instability, and radiation-altered corrosion.

122 ft control techniques to compensate for this instability, and then demonstrate that the instability h

123 cellular proliferation and apoptosis, genome instability, angiogenesis and metabolic dysregulation.

124 ied where intermittent cascading interfacial instabilities appear.

125 By contrast, in ring lasers instabilities are considered to occur only under extreme

126 This instability arises from the phase-amplitude coupling of

127 al to full contact including jump-to-contact instabilities as well as load-depth hysteresis.

128 findings highlight TRIM37-dependent genomic instability as a putative driver event in 17q23-amplifie

129 ere, we report the results of a GWAS of mood instability as a trait in a large population cohort (UK

130 ject to plasma instabilities like the Weibel instability as they propagate through the thermal popula

131 rovide possible explanations for the genomic instability, as well as the osteolytic phenotype of GCTB

132 BglA, despite an apparent instability at low pH, is twice as effective in releasin

133 arising during transcription induce genomic instability, but how cells respond to the R loop-associa

134 nutrient transport theory suggests that such instabilities can be amplified over vast distances from

135 ency (HRD), which we attribute to chromosome instability caused by unrepaired DNA gaps at replication

136 holes on the iodide site in the MHP induces instability causing iodide from the lattice to move away

137 ipin remodeling and respiratory supercomplex instability characteristic of human Barth syndrome but n

138 Conversely, T(reg) instability, characterized by loss of the master transcr

139 in kinetochore biorientation and chromosomal instability (CIN) and these phenotypes are suppressed by

140 Chromosomal instability (CIN) comprises continual gain and loss of c

141 correlated with the levels of the chromosome instability (CIN) genes MAD2 and CDC20.

142 Chromosomal instability (CIN) increases a tumor cell's ability to ac

143 Besides acquired T790M mutation, chromosomal instability (CIN) related genes, including AURKA and TP5

144 ed by TP53 mutation and extensive chromosome instability (CIN).

145 recovered proficient control under different instability conditions and across multiple days.

146 We also explore phonon-instability conditions that promote phase transition to

147 Postural and walking instabilities contribute to falls in older adults.

148 ty, and illustrate how the wavelength of the instability determines the size of the final platelets.

149 ition to the separate wrinkling and buckling instabilities developed under their respective geometric

150 Repeat instability emerges first, followed by larger aberration

151 al dysfunction, telomere shortening, genomic instability, epigenetic changes, protein aggregation, an

152 The human Immunodeficiency Centromeric Instability Facial Anomalies (ICF) 4 syndrome is a sever

153 tumors and have been associated with genetic instability favoring tumor progression.

154 Here, we investigate the vapor film instability for small length scales that ultimately sets

155 lecular level: somatic and intergenerational instability, fragility, and repeat-induced mutagenesis.

156 The critical keyhole instability generates acoustic waves in the melt pool th

157 actions with Saccharomyces cerevisiae genome instability genes, is a druggable target for an inhibito

158 Genomic instability (GI) predisposes cells to malignant transfor

159 s instability, and then demonstrate that the instability has been suppressed.

160 Although some consequences of this instability have already been empirically described, the

161 eral features were suggested to underlie CFS instability, however, these features are prevalent acros

162 nic uplift, is reminiscent of the subsequent instabilities in fluid turbulence, while the structure o

163 Mechanical instabilities in the active cytoskeleton network and fee

164 rious hot-spot mutation increased chromosome instability in a wild-type (WT) background, suggesting t

165 ) to overcome sluggish kinetics and catalyst instability in acids.

166 luids and offers evidence of polymer micelle instability in biologic fluids that is not explained by

167 The extent of instability in both analyses is in concordance with the

168 CST complex inactivation exacerbates genome instability in BRCA2 deficient cells.

169 Chromosomal instability in cancer consists of dynamic changes to the

170 tion stress and are hotspots for chromosomal instability in cancer.

171 r investigating mechanisms promoting genomic instability in cancer.

172 iratory failure with hypoxia and hemodynamic instability in critically ill patients.

173 pool can significantly contribute to genetic instability in DNA mismatch repair-defective human tumor

174 anded DNA that represent a source of genomic instability in mammalian cells(1-4).

175 d DNA damage could not only increase genomic instability in metastasizing cancer cells but could also

176 hat eroded telomeres lead to differentiation instability in murine embryonic stem cells (mESCs) via D

177 To address the importance of genomic instability in prostate carcinogenesis and tumor progres

178 (R-loops) and DNA damage leading to genomic instability in SMA mice and patient cells.

179 hy, ventricular arrhythmias, and hemodynamic instability in the absence of obstructive coronary arter

180 and neostriatum tending to have the greatest instability in the CNS, and liver in the periphery.

181 nto the DMN after meditation) and (2) led to instability in the community allegiance of the regions i

182 Msh3, are required for Z-DNA-induced genetic instability in yeast and human cells.

183 rohormonal stress, angiogenesis, and genomic instability, in an effort to understand common mechanism

184 tron retention (IR) could lead to transcript instability, in this study, we performed BruChase-Seq to

185 rolled during development to prevent genomic instability, inappropriate gene activation and other mal

186 n was incompletely reprogrammed, and genomic instability increased during replicative stress.

187 s paper utilizes Critical Slowing Down (CSD; instability) indicators developed by statistical physics

188 overexpression suppresses R loops and genome instability induced by depleting five different unrelate

189 lent infectivity without evidence of genetic instability, induced durable immunity, and primed for an

190 has been limited by factors such as chemical instability, inefficient intracellular delivery, and the

191 This wetting is driven by a bulk instability introduced by metastable LLPS exposed to an

192 Genomic instability is a hallmark of cancer, and has a central r

193 This instability is akin to the surface tension-induced break

194 Enzyme instability is an important limitation for the investiga

195 ping levels owing to phase turbulence(11)-an instability known to occur in hydrodynamics, superconduc

196 of limited dNTP pools, Top1-mediated genome instability leads to severe growth defects.

197 stic electron currents are subject to plasma instabilities like the Weibel instability as they propag

198 Thus, genetic predisposition to proteome instability may be a determinant in the pathogenesis of

199 Chromosomal instability may enable the continuous selection of SCNAs

200 (ii) can we use current knowledge on repeat instability mechanisms to cure repeat expansion diseases

201 solubilities of constituent elements, phase instability, microstructures, and resulting TE propertie

202 he correlation between specimen geometry and instability modes, as well as how the deformation increm

203 ed image; and 3) (a counterintuitive type of instability) more samples may yield poorer performance.

204 ree survival in patients with microsatellite instability (MSI) cancers, but no such correlations were

205 R immunohistochemistry (IHC), microsatellite instability (MSI), and targeted MLH1-methylation testing

206 ecular pathological features: microsatellite instability (MSI), CpG island methylator phenotype (CIMP

207 umor mutational burden (TMB), microsatellite instability (MSI), programmed cell death protein 1 (PD-1

208 models that account for the Rayleigh-Taylor instability, nucleation rates, and superheat limits.

209 m and synovial fluid, with varying levels of instability observed in ascites and pleural fluid.

210 d, yielding an absolute fractional frequency instability of 1 x 10(-18) in the electronic domain.

211 tion could be used to infer possible process instability of anaerobic digesters.

212 The chemical instability of Citral in acidic conditions is viewed as

213 In vivo imaging reveals instability of endoplasmic reticulum (ER) in mouse AD mo

214 Here, we investigate whether the intrinsic instability of gene duplication and amplification provid

215 ning speed) macroscopic, while the intrinsic instability of in-series force generators is likely prev

216 ism of prion replication in which structural instability of incompletely glycosylated PrP contributes

217 Dynamic instability of microtubules is characterized by stochast

218 the mitochondria and the lysosome; including instability of mitochondrial DNA due to the lack of the

219 The instability of neural recordings can render clinical bra

220 The operational instability of perovskite solar cells (PSCs) is known to

221 evated levels of radiation contribute to the instability of pharmaceutical formulations in space comp

222 Sea-level rise resulting from the instability of polar continental ice sheets represents a

223 t research groups, it becomes clear that the instability of superoxide in the presence of Li ions (Li

224 hat mutation to methionine (M170) results in instability of the CHPK protein.

225 ging to characterize because of the inherent instability of the cluster at the interface.

226 In particular, the apparent instability of the conductive conformation of the TWIK-1

227 inistration minimized premature cleavage and instability of the drug in plasma and enabled higher dru

228 h charge density, the low abundance, and the instability of the esters and anhydrides.

229 ted substrates have been isolated due to the instability of the high-valent Pd(IV) center.

230 species; unfortunately, due to the inherent instability of the interface, it is rather poorly explor

231 tal batteries (LMBs) is still impeded by the instability of the interphase between the lithium metal

232 The instability of the MOC junctions in the Cu(I) and Cu(0)

233 activation is currently limited by metabolic instability of the natural cyclic dinucleotide (CDN) lig

234 mutations in the dystrophin gene, leading to instability of the sarcolemma and skeletal muscle necros

235 d both MSCs (P < 0.05) and indicated greater instability of the solid-like structure in the temperatu

236 ignaling centers, highlighting the intrinsic instability of the upper molar developmental system.

237 ematopoietic tumors often experience genomic instability, oncogene activation, increased protein secr

238 did not induce significant post-VR postural instability or maladaption of the vestibulo-ocular refle

239 patterns, typically construed as disruptive 'instability' or an undesirable consequence of noise, may

240 nthesis conditions, aggregation from product instability, or degradation during storage.

241 xcitonic condensation is hampered by Peierls instability, or other bilayers, where doping by applied

242 sociated with a reduced risk of haemodynamic instability, organ injury and improved outcomes in criti

243 ngular in its origin, cyclicity, complexity, instability, perpetuity, and breadth of clinical consequ

244 in DNA repair may lead to cancer and genetic instabilities, Pol beta has been extensively studied, es

245 elucidation of factors enabling the genomic instability present in this subtype has the potential to

246 ctory electrical storm and their hemodynamic instability prevents emergency catheter ablation.

247 their wider application has been hampered by instability problems.

248 ction of spinwaves generated via a nonlinear instability process where spinwaves of nonzero wavevecto

249 Different genetic instability processes result in characteristic non-rando

250 Herein, we use the AAV-PHP.eB to deliver an instability-prone Mecp2 (iMecp2) transgene cassette whic

251 Analogously to fitness landscapes, the instability rates of clonal populations form their mutab

252 anifests itself in high variability of clone instability rates.

253 ation of cells with a high degree of genomic instability remain unclear.

254 use, but the mechanisms that protect from Xi instability remain unknown.

255 gnatures representing HPV and microsatellite instability remained significant in multivariate analysi

256 atomistic mechanistic details of the dynamic instability remains unclear.

257 In photonics, wave instabilities result in modulated light waveforms that c

258 ur types to show that continuous chromosomal instability results in pervasive SCNA heterogeneity.

259 lication stress are major sources of genomic instability, selective ATR inhibition has been recognize

260 (CRC) but its rapid metabolism and systemic instability (short half-life) has hindered its therapeut

261 ousals may result from a sleep-wake boundary instability, suggesting a bidirectional relationship.

262 ering materials capable of EM field control, instability suppression including those observed in high

263 ) allele, likely via mechanisms unrelated to instability suppression.

264 Fanconi anemia (FA) is a chromosome instability syndrome of children caused by inherited mut

265 reducing the susceptibility of implosions to instabilities that inject this mass.

266 als, with the concomitant appearance of some instabilities that lead in particular to the formation o

267 duplications and creates hotspots of genomic instability that appear to be an ancient property of pri

268 centromeres (dicentrics) trigger chromosome instability that is avoided by the enigmatic process of

269 re that the fundamental electronic structure instability that leads to Jahn-Teller (lattice) distorti

270 at the boundary of the colony and trigger an instability that leaves behind striking flower-like patt

271 Due to cardiovascular instability the patient was admitted to the local Intens

272 es in gene copy number contribute to genomic instability, the onset and progression of cancer, develo

273 surface minimization drives Rayleigh-Plateau instabilities, these streams of metal increase in surfac

274 driven bioconvection and the Rayleigh-Benard instability, these rely on a density mismatch between la

275 By inducing genetic instability, they can accelerate the evolution of human

276 After surgically induced joint instability, TIMP3 overexpression proved to be less prot

277 s of Bap1 in murine pancreata causes genomic instability, tissue damage, and pancreatitis with full p

278 either closed structures or with structural instabilities to generate cyclic motion.

279 ticular, we highlight cases that utilize MOF instability to fabricate varying materials including hie

280 However, their chemical instability towards oxygen, light and heat limits its ap

281 cal significance is challenging due to their instability under physiological conditions.

282 The instabilities usually occur in several forms: 1) Certain

283 (3) Hypoxia-inducible factor 1alpha protein instability was associated with impaired glucose metabol

284 Genomic instability was rescued by simultaneous depletion of mac

285 displacement, likely related to the natural instability, was already visible in 2007 on various sect

286 e the Risken-Nummedal-Graham-Haken multimode instability, we envisage the usefulness of the CME for d

287 Forty six unique loci associated with mood instability were identified with a SNP heritability esti

288 es, and subjective measures of state anxiety/instability were recorded per trial.

289 rience discrete episodes of systemic genomic instability, when the entire genome becomes vulnerable a

290 similar to Saffman-Taylor viscous-fingering instabilities, which occur at moving interfaces between

291 -gain excitatory networks are susceptible to instability, which can lead to runaway activity, as mani

292 e show that the limitations imposed by fluid instabilities with thermally drawn nanowires can be alle

293 l cause of acute flank pain and haemodynamic instability with acute kidney failure and high mortality

294 early RFI volatility and (2) cumulative RFI instability with aggregate increased RFI were associated

295 HGSOC tumors exhibit genomic instability with frequent alterations in the protein kin

296 and when active, are thought to cause genome instability with potential benefit to genome evolution.

297 nematic bands show a local symmetry-breaking instability within their high-density core region, which

298 networked systems captures their structural instability without relying on structural information.

299 ay that eliminates electromechanical pull-in instability without restricting the dynamic range of mot

300 eplication forks are main sources of genomic instability, yet the molecular mechanisms for protecting