ライフサイエンスコーパス: instructive

1 s the question of whether these dynamics are instructive.

2 udy evaluating platelet aggregation would be instructive.

3 ation-activating gene (RAG) mutations may be instructive.

4 disease (including rubella and Zika) may be instructive.

5 tum women access and remain in care would be instructive.

6 ional Cancer Institute-sponsored studies are instructive.

7 ial tissues, it remains unclear whether such instructive activity is also critical for directed mesen

8 Each signalling pathway has instructive activity: neither acts simply to repress act

9 l and gas deposits in shales demonstrated an instructive agreement with the prediction of the model.

10 een theory and evidence and show by means of instructive analysis and simulation how much of the expe

11 This gradient is functionally instructive, and represents a multistable, epigenetic an

12 atterns of silent synapses and thus provided instructive animal models to examine the role of NAc sil

13 toprotection point of view to that of a cell-instructive approach is examined, with advances in the u

14 t, we have adopted two parallel and mutually instructive approaches to mimic the human enzyme: firstl

15 ndings in Df(16)A(+/-) mice are particularly instructive as they are localized to specific areas with

16 Our data identify an instructive astrogenic program that acts as a binary swi

17 Vocal imitation involves incorporating instructive auditory information into relevant motor cir

18 As a consequence of the polarity defects, instructive auxin gradients as well as embryonic and pos

19 tribution within the meristem, generating an instructive auxin minimum that positions the TZ [10].

20 Finally, Netrin localization is instructive because expression in ectopic layers can ret

21 Their activity is instructive because the A-neurons can induce scanning- a

22 s will be required to produce hydrogels with instructive biochemical microenvironments necessary to a

23 nts a first step in the design of novel cell-instructive biomaterial surfaces.

24 cal development of ASIT for allergy has been instructive, but limited understanding of CD4 T cell epi

25 discussed first, followed by conceptual and instructive case studies.

26 , although diagnosis may be complicated, and instructive cases are described.

27 quency-independent plasticity control by the instructive CF signal based on relative, not absolute, c

28 as the critical parameter contributed by the instructive CF signal.

29 ves learning that is temporally linked to an instructive change in target motion, and that this may b

30 a single oriented grating) causes immediate, instructive changes in the firing of mouse lateral genic

31 by which physical cues are converted to cell-instructive chemical information to influence cell behav

32 eroxide released from a wound is the initial instructive chemotactic cue for the infiltration of infl

33 of its ligands in cancer, with reference to instructive clinical observations and translational appr

34 how that Dscam expression levels serve as an instructive code for the size control of presynaptic arb

35 ropose that a terminal calcium wave is a key instructive component of the axon degeneration program.

36 findings highlight the need to consider the instructive contributions of metals-and, more generally,

37 elial cells requires Olfml3 to provide early instructive cue and retain PDGF-B along newly formed ves

38 adhesion protein E-cadherin functions as an instructive cue for cell division orientation.

39 model wherein E93 expression functions as an instructive cue that defines a broad window of developme

40 hP) regulates brain development by secreting instructive cues and providing a protective brain barrie

41 Alginate hydrogels containing cell-instructive cues are the subject of intense interest for

42 t Dlg1 localization may additionally provide instructive cues for spindle orientation.

43 Hematopoietic stem cells (HSCs) rely on instructive cues from the bone marrow (BM) niche to main

44 y of neural crest cell-intrinsic factors and instructive cues from the surrounding gut mesenchyme.

45 ting potentials among non-excitable cells as instructive cues in embryogenesis, regeneration, and can

46 Instructive cues provided by infarct-primed dendritic ce

47 ocation for brain tumor spread; however, the instructive cues responsible for this unique tropism wer

48 Dying cells provide instructive cues that can influence surrounding cells to

49 ory input; however, the experience-dependent instructive cues that organize retinotopy are unclear.

50 rein Notch signaling in vSMCs provides early instructive cues to neighboring ECs important for optima

51 muscular contractile apparatus provides the instructive cues to pattern proprioceptive dendrites.

52 IL-33 is an instructive cytokine of type 2 inflammation whose expres

53 phenotype shortly after birth in response to instructive cytokines, and then self-maintain throughout

54 st, thus illustrating that miRNAs can act as instructive determinants of cell fate during development

55 cilitated functional experiments that reveal instructive developmental bioelectric signals.

56 y, we found remarkable similarities but also instructive differences of PAg-recognition by human and

57 n HSC niches, where they encountered lineage-instructive differentiation signals.

58 sms provide a symmetry-breaking seed for the instructive effects of visual experience.

59 it is not known whether the vasculature has instructive effects on the epithelium.

60 y for a requirement for endothelial cells in instructive epithelial patterning, we developed a novel

61 Our results demonstrate that stochastic and instructive events differentially contribute to shaping

62 e TCGA and the Cancer Moon Shot, provides an instructive example as we see different perspectives pro

63 Our work provides an instructive example of how different evolutionary strate

64 y from ischemic heart disease, as well as an instructive example of the challenges in obtaining and i

65 d on the number of behaviours covered by the instructive examples and link techniques with their pote

66 This tutorial review discusses instructive examples that have substantially broadened t

67 hich is labelled, defined and presented with instructive examples to facilitate self-enactment.

68 Our own Galaxy's SMBH provides an instructive exception, and we present a close-up view of

69 of mitotic spindle alignment in response to instructive, external cues.

70 Recently, however, it is suggested that instructive extrinsic signals from the trunk and apical

71 we implicate endogenous bioelectricity as an instructive factor during brain patterning in Xenopus la

72 ctor, involved in lymphocyte survival, or an instructive factor, involved in lymphocyte differentiati

73 or passively confer competence to respond to instructive factors.

74 ely establish retinal waves as necessary and instructive for circuit refinement in the developing ner

75 seizures and epileptiform activity that are instructive for clinical practice and highlight similari

76 are highly expressed, our findings might be instructive for cost-effective experimental designs in N

77 This strategy might be instructive for designing assembly of various nanopartic

78 of the dATP-induced changes in myosin may be instructive for determining the structural changes desir

79 nfections, such as HIV and tuberculosis, are instructive for developing a more rational approach for

80 Notch is permissive but not instructive for differentiation of multiple cell types.

81 nvestigate H2O2 in AD brains and can be very instructive for drug development.

82 This suggests that ppk301 is instructive for egg-laying at low-salt concentrations, b

83 These in silico analyses are instructive for functional studies of the HS-linked muta

84 action, which is usually overlooked, will be instructive for future research on CVD growth of graphen

85 s suggest that asymmetric auxin distribution instructive for gravity-induced differential growth is c

86 These findings are instructive for lignin engineering strategies to improve

87 le transformations indicate that the code is instructive for sexual dimorphism.

88 We found the thalamic environment is instructive for TCA navigation and that the molecular cu

89 erns encoded in the waves are believed to be instructive for the wiring of functional connections thr

90 ecific receptor guanylyl cyclases (rGCs) are instructive for thermosensation.

91 Genetic manipulation shows that the BM is instructive for tissue elongation and the determinant is

92 While it is clear that neural activity is instructive for topographic alignment of inputs from the

93 dence, posits that histone modifications are instructive for transcriptional regulation and represent

94 n altered chromosomes, indicating a powerful instructive function for CTCF in chromatin folding.

95 Thus, maternal H4K16ac provides an instructive function to the offspring, priming future ge

96 used inducible lineage-tracing from the MPC-instructive gene Ptf1a to define systematically in mice

97 ive domain and recruited other pancreas-fate-instructive genes, thereby spatially enlarging the poten

98 Flipons are elements of a binary, instructive genetic code directing how genomic sequences

99 This paper provides instructive guidance on the usage of cooking technologie

100 these systems and explore the concept of an instructive heparan sulfate sugar code for modulating ve

101 ir interplay creates chaos is explained with instructive illustrations but without any equations.

102 olving the puzzle of homochirality, but also instructive in chiral separation and stereoselective cat

103 Mouse models are instructive in developing a mechanistic understanding of

104 ctrometry and ion mobility (IM-MS), are also instructive in exploring conformational landscapes in th

105 ine if these changes in gene expression were instructive in human disease, we compared our liver-spec

106 ed the positions of the duplications and was instructive in interpreting their distinct pathogenic ef

107 (OA) were either too slow or too small to be instructive in predicting near-future impacts.

108 Activity can be instructive in refining visual projections by directly m

109 mechanism of action of methotrexate could be instructive in the appropriate use of the drug and in th

110 ar whether experience exerts a permissive or instructive influence.

111 selectivity to these patterns, indicating an instructive influence.

112 ical phenotype is, however, not direct, with instructive information progressing both across multiple

113 Here we report instructive input of Frizzled-PCP (Fz/PCP) signalling in

114 ell niches, where neighbouring cells provide instructive inputs that govern cell fate decisions.

115 sulting in transmission to the fetus provide instructive lessons that can be applied to the prospecti

116 tal Cell, Minegishi et al. (2017) uncover an instructive link from Wnt5a/b gradients to PCP-factor-re

117 We conclude that dsx does not act in an instructive manner to regulate male versus female niche

118 es, controlling their microenvironment in an instructive manner.

119 nd in this context hydrogels can serve as an instructive matrix.

120 the possible His-E7 states as well as in two instructive Mb mutants: Ala-E7 and Trp-E7.

121 ies are not a surprise, providing in fact an instructive measure of the approximations used in the mo

122 nscription suggest drought sets in motion an instructive mechanism guiding epigenetic machinery towar

123 n through two general, inductive mechanisms: instructive mechanisms that act directly on muscle cells

124 hioalveolar stem cells (BASCs), to probe the instructive mechanisms.

125 patterned electrospun meshes will define an instructive microenvironment for guided tissue formation

126 his form of gestural communication offers an instructive model for examining the origin and evolution

127 Chlorella virus DNA ligase (ChVLig) is an instructive model for mechanistic studies of the ATP-dep

128 lid tumors and provide strong support for an instructive model of oncoprotein-directed epigenetic sil

129 Gephyrin is the major instructive molecule at inhibitory synapses, where it cl

130 However, in the CNS, no such instructive molecules have been shown to be required, an

131 te this understanding, the role of Shh as an instructive morphogen is viewed as increasingly complex,

132 KEY POINTS: The inferior olive sends instructive motor signals to the cerebellum via the clim

133 surfaces thus prompting the search for cell-instructive nanoscale patterns.

134 longevity mutants discovered in the lab are instructive of cellular physiology, lab studies might mi

135 e manner of cell death is, therefore, highly instructive of the immunological consequences that ensue

136 ferent blood lineages by acting either in an instructive or a permissive manner.

137 le visual system to test whether activity is instructive or permissive for shaping development of the

138 n the epithelial plane, but whether Wnts are instructive or permissive is debated.

139 is unclear, however, whether Hand2 plays an instructive or permissive role during this process.

140 Whether changes in inhibition have an instructive or permissive role in plasticity remains unc

141 ples, aiming at providing the reader with an instructive overview on how the wavelength-selective cle

142 erpinnings of glioblastomas has served as an instructive paradigm for other cancers.

143 this interaction may be conserved and is an instructive part of planarian posterior regeneration.

144 at chromosomal locations, consistent with an instructive pattern of methylation, and were in part det

145 cieties have dealt with acute stress, a more instructive perspective for the future than is offered b

146 This paper describes a simple, remarkably instructive physical model for examining the eruption of

147 At the end of the instructive placebo procedure, the two experimental grou

148 development progresses via an early phase of instructive plasticity, when the specific patterns of ne

149 Instructive polymer scaffolds with a wide range of prope

150 These data demonstrate an instructive positional role for Hofstenia muscle and thi

151 olarization more often occurs as the initial instructive process for patterning ACD especially in the

152 gnaling pathways are now appreciated to have instructive rather than bystander roles in regulating ce

153 tage of NK cell maturation and hinged on the instructive recognition of allogeneic ligand by the acti

154 chemotactic cues and modulating secretion of instructive regenerative molecules in response to dynami

155 aints of the surrounding environment provide instructive regulations in nervous system wiring.

156 Retinal waves provide instructive retinotopic information for the anatomical o

157 tatory and inhibitory neurons, suggesting an instructive role and a common downstream synapse additio

158 of an individual animal's experience play an instructive role and influence the tuning parameters of

159 anism, in which VEGF-FLK1 signaling plays an instructive role by promoting Etv2 threshold expression.

160 These findings reveal an instructive role for FOS and SCG2 in establishing a netw

161 ties of spontaneous activity, suggesting its instructive role for generating functional variability i

162 in an Ir25a-dependent manner, suggesting an instructive role for IR21a in thermosensing.

163 These data reveal a new, instructive role for membrane voltage during embryogenes

164 cient to alter glial layering, indicating an instructive role for neuronal cues.

165 This work reveals an instructive role for patterned spontaneous activity in g

166 eres with cardiac fusion, consistent with an instructive role for PDGF signaling.

167 Our findings demonstrate an instructive role for serotonin in axon guidance acting t

168 ir maintenance, consistent with a transient, instructive role for simple spikes during cerebellar lea

169 issue of Neuron, Timofeev et al. describe an instructive role for the guidance molecule Netrin and it

170 Our findings support an instructive role for the interneuron AVB in controlling

171 output of a tectal neuron plays an important instructive role in development of its receptive field p

172 reveal that endothelial cells have a direct instructive role in driving metastatic dissemination, an

173 rimordium, suggesting that CNC cells play an instructive role in guiding tongue muscle development.

174 inherent histone amplifier activity with an instructive role in impacting the epigenetic landscape,

175 cription factor Tramtrack69 (Ttk69) plays an instructive role in inhibiting the growth of R7 photorec

176 D-induced changes in FS interneurons play an instructive role in ocular dominance plasticity, causing

177 We show that MES-1/Src signaling plays an instructive role in P(2) for asymmetric GPR-1/2 localiza

178 gest that this transcription factor plays an instructive role in presynaptic Ca(2+) signaling in IHCs

179 nd discuss whether genome structure plays an instructive role in regulating gene expression or is a r

180 ence in teleosts that the notochord plays an instructive role in segmental patterning, alongside the

181 s suggest that CySCs do not have a necessary instructive role in specifying GSC self-renewal and that

182 lt plasticity, precise spike timing plays an instructive role in synaptic modification.

183 Thus, our data propose that Nxph1 plays an instructive role in synaptic short-term plasticity and t

184 ructures but the extent to which it plays an instructive role in synaptic specification remains unkno

185 canonical Notch signaling plays a positive, instructive role in the differentiation of SCs.

186 lated by synaptic activity and thus plays an instructive role in the turnover of synaptic membrane pr

187 on extension, indicating that Ttk69 plays an instructive role in this process.

188 Epo, therefore, has a lineage instructive role in vivo, through suppression of non-ery

189 Our work uncovers an instructive role of a developmentally regulated tubulin

190 The instructive role of citrate in inter-organ communication

191 aging-associated phenotypes, confirming the instructive role of EC-derived signals in governing HSPC

192 herefore support a permissive rather than an instructive role of inhibition in ocular dominance plast

193 These results underscore the instructive role of intrinsic mechanisms in synapse form

194 However, the proliferation-independent instructive role of metabolic enzymes in tumor plasticit

195 However, the instructive role of microRNAs (miRNAs) in neurogenesis r

196 lls and provides additional insight into the instructive role of the mechanical tumor microenvironmen

197 genous plate to orient correctly, showing an instructive role of the plate in establishing directiona

198 n in pancreatic cancer, thus highlighting an instructive role of tumor cell lineage in reprogramming

199 These observations provide evidence for the instructive role of Wnt ligands in vertebrate PCP.

200 tural processes in morphogenesis and play an instructive role to a level that can direct developmenta

201 ting that the TCR affinity does not play the instructive role, and that restricted presentation of pe

202 ient to induce this program, revealing a key instructive role.

203 AP NF1 is mutated, showing that Ras plays an instructive role.

204 thylation and as a modified DNA base with an instructive role.

205 ell microenvironment from a 'hostile' to an 'instructive' role, thus facilitating the healing or rege

206 ed in vitro brain tissue models, despite its instructive roles during development.

207 dermal origin of Gryllus PGCs and absence of instructive roles for vasa and piwi in PGC formation are

208 Regulated calcium signals play conserved instructive roles in neuronal repair, but how localized

209 lthough it is known that the centrioles play instructive roles in pericentriolar material (PCM) assem

210 ve, indeed, been proposed to exhibit active, instructive roles in the formation of synapses.

211 These data reveal instructive roles of Ca(V)1.2 in limb development, and m

212 thetic functional biomaterials have revealed instructive roles of individual extracellular biophysica

213 tial for implementing this coordination, the instructive roles of mechanical inputs are not clear.

214 However, the process by which these instructive roles play out during synaptogenesis is not

215 whether endothelial cells also have active 'instructive' roles in the dissemination of cancer.

216 Such information is useful in designing instructive scaffolds or supporting substrates for neura

217 (GSCs), with CySCs as the proposed source of instructive self-renewal signals.

218 ctions, we asked whether spike timing is the instructive signal at inputs competing for synaptic spac

219 B, post-crossing commissural axons lacked an instructive signal directing them rostrally along the co

220 of the periocular airpuff that served as the instructive signal for eyeblink conditioning.

221 ic Protein (BMP) family member, provides the instructive signal for initiating vn expression.

222 uring stress, endocrine IL-6 is the required instructive signal for mediating hyperglycemia through h

223 peed of change of ligand concentration is an instructive signal for patterning.

224 These neurons could provide a common instructive signal for reward-seeking and information-se

225 Fluctuating inputs therefore act as an instructive signal for seeds, enhancing the accuracy wit

226 These results identify WntA as an instructive signal for the prepatterning of a biological

227 ays are involved in transmitting the lineage-instructive signal in primary bone marrow-derived GM pro

228 ve been shown to encode a particular type of instructive signal known as a temporal difference predic

229 climbing fiber (CF) coactivation provides an instructive signal that further enhances calcium transie

230 is sufficient to transmit the CSF-1 lineage instructive signal.

231 file of mature microglia requires continuous instructive signaling from the intact CNS.

232 However, how cellular mechanics affects the instructive signaling pathways controlling cell fate is

233 To investigate how these instructive signals are encoded, we recorded the activit

234 depend exclusively on hepatocytes receiving instructive signals by endothelial cells, since silencin

235 ar, nonlinear effects on the putative neural instructive signals carried by cerebellar climbing fiber

236 In contrast, putative neural instructive signals carried by the simple spikes of Purk

237 Instructive signals determine whether LTP or LTD is indu

238 in complex and dynamic environments wherein instructive signals fluctuate on various timescales.

239 aminergic neurons ultimately provide the key instructive signals for both appetitive and aversive lea

240 CA1 pyramidal neurons through the PP provide instructive signals for hippocampal long-term synaptic p

241 The same graded impact of instructive signals for plasticity and learning might oc

242 al HNF4A-TFIID interactions therefore act as instructive signals for post-natal hepatocyte differenti

243 Neural circuits in the spinal cord transform instructive signals from the brain into well-coordinated

244 esults suggest that MyD88 signaling mediates instructive signals in DCs and secretion of IL-1beta and

245 as a central pathway for the integration of instructive signals in DCs for T(H)17 differentiation an

246 in erythroblasts, sensitizing HSCs to T-cell instructive signals in the BM.

247 However, recent work on the ChP and instructive signals in the CSF have sparked new hypothes

248 uggesting that Wnt5 and Sfrp proteins act as instructive signals in this process.

249 Instructive signals mediated by changes in resting poten

250 tion of HSCs is dependent on the presence of instructive signals on the ventral side of the vessel.

251 cell help for cellular immunity is guided by instructive signals received during DC maturation, as we

252 The dermal papilla (DP) provide instructive signals required to activate epithelial prog

253 are thought to be involved in generating the instructive signals that drive cerebellar learning.

254 the cerebellar cortex is thought to provide instructive signals that drive the induction of motor sk

255 e we show that bitter and sweet TRCs provide instructive signals to bitter and sweet target neurons v

256 gether groups of Purkinje neurons to provide instructive signals to downstream sites in the cerebella

257 ng portal fibroblasts also provide important instructive signals to promote the proliferation and dif

258 Doublet activity may provide a means for CF instructive signals to stand out from background firing.

259 ABSTRACT: The inferior olive conveys instructive signals to the cerebellum that drive sensori

260 erived permissive signal with stress-induced instructive signals, adjusting ISC proliferation to envi

261 spike-bursts are believed to serve as potent instructive signals, which increase the efficiency of in

262 ack to a pluripotent state under appropriate instructive signals.

263 pes go even further by adding objectives and instructive signals.

264 Charney has provided an instructive snapshot of where we are in meeting this cha

265 etrieval of the response associated with the instructive stimuli (lever pressing on GO, withholding o

266 ndritic calcium that marks the occurrence of instructive stimuli during cerebellar learning.

267 sponses to periocular airpuffs that serve as instructive stimuli during cerebellar-dependent eyeblink

268 lying neuronal determinants of incentive and instructive stimuli in the same task.

269 the attention toward reward-seeking, whereas instructive stimuli inform about the action to perform.

270 log information that encodes the strength of instructive stimuli trial-by-trial.

271 nded more strongly to the incentive than the instructive stimuli.

272 a stronger representation of incentive than instructive stimuli.

273 are all-or-none and only signal whether the instructive stimulus has occurred, without providing par

274 hat reduce inhibition, when combined with an instructive stimulus, could facilitate restructuring of

275 ed responses to the incentive but not to the instructive stimulus.

276 Radial glia therefore provide an instructive structural matrix to coordinate the generati

277 axial motoneurons that progressively rely on instructive synaptic drive to shape their oscillatory ac

278 changes in communicative performance during instructive tasks, while simpler word-description tasks

279 The ventral telencephalon acts as an instructive tissue, but the importance of the diencephal

280 gside in vivo and in vitro techniques, it is instructive to consider in vacuo methodologies: for exam

281 role in the etiology of human cancer, it is instructive to consider mechanisms underlying normal GAT

282 intrinsic to cellular differentiation, it is instructive to consider the role of RNA regulatory machi

283 ocesses and their relative importance, it is instructive to develop physiologically representative ma

284 al failures of mouse genetic modeling can be instructive to human tumor biology.

285 e absence of new drug development, it may be instructive to look back at the research methods used du

286 DA) receptor-dependent Ca(2+) transients are instructive to minicolumn organization because Crispr/Ca

287 ible lessons from each example that might be instructive to students.

288 These results are instructive to the development and improvement of predic

289 rium" or "out-of-equilibrium", and it can be instructive to think of them as adopting thermodynamic s

290 pertinent for aging in general and that are instructive to understand naive T cell dysfunction.

291 kine-driven ES-DC development and acts as an instructive tool for the generation of mature DCs with e

292 ies dissolve and release mRNAs encoding fate-instructive transcription and chromatin factors that re-

293 Using a combinatorial screen for lineage-instructive transcription factors, we identified a pool

294 n in the visceral endoderm (VE) initiates an instructive transcriptional program controlling AP ident

295 In addition to the instructive value of our study, we believe that the insi

296 as FGRS), and then propagated on serum-free instructive vascular niche monolayers to induce outgrowt

297 An instructive way to investigate the relationship between

298 minus and a well-folded core that differs in instructive ways from the crystal structure of a PaePE*M

299 ethod and explanation of approaches that are instructive when designing a study.

300 effect in lithium-sulfur batteries, and are instructive when it comes to selecting the most suitable