ライフサイエンスコーパス: instrumental

1 of appropriate reference gene transcripts is instrumental.

2 might superficially seem merely clinical and instrumental.

3 ns can hinder the ability to learn flexible "instrumental" actions in pursuit of a goal.

4 ed using repeat measures of limitations with instrumental activities and activities of daily living a

5 1.4-4.8), and 3.2 times the odds of impaired instrumental activities of daily living (95% CI: 1.6-6.3

6 ease Research Center UDS battery), basic and instrumental activities of daily living (Alzheimer Disea

7 g alloHCT, functional status, as measured by instrumental activities of daily living (IADL) and gait

8 of activities of daily living (ADLs) and/or instrumental activities of daily living (IADLs) requirin

9 between functional capacity, measured by the Instrumental Activities of Daily Living scale, and 3 sub

10 ean difference in activities of daily living/instrumental activities of daily living score = 0.15, 95

11 , sign and symptom with a profound effect on instrumental activities of daily living.

12 , and the activity of daily living (ADL) and instrumental ADL (IADL) scales.

13 These results are instrumental also from the perspective of a future clini

14 When subjected to PLS the data from the instrumental analysis yielded a satisfactory model for t

15 in a simpler method compared to conventional instrumental analytical techniques.

16 least-cost path problem has proven to be an instrumental analytical tool in this sense.

17 ocess takes 2-3 d, whereas the time spent on instrumental and data analyses could vary from 1 to 5 d

18 ciency and potential sources of error due to instrumental and data processing methods were evaluated.

19 that intergenerational ties are a source of instrumental and emotional support, which may favor comp

20 This new instrumental and methodological approach is an important

21 n by subjective value that is shaped by both instrumental and noninstrumental motives, and that this

22 he BM task employed (first-order, direct and instrumental), and according to the manipulation of low-

23 Fourth, the ACC dynamically controls instrumental- and non-instrumental information seeking b

24 vestigated utilizing different complementary instrumental approaches.

25 uding endogenous and exogenous compounds and instrumental artifacts) with an accuracy rate of 96% (+/

26 tions despite being a widely used region for instrumental-based NAO measurements.

27 ibes the influence of conditioned stimuli on instrumental behaviors and is discussed as a key process

28 tive for information seeking, in addition to instrumental benefits.

29 component was related to the strength of the instrumental bias during learning.

30 entation of labour, pain relief, episiotomy, instrumental birth, and cesarean section (CS).

31 DMSP/OLS, SNPP/VIIRS-DNB and ISS is not only instrumental, but in fact represents a real detection of

32 ates in concentrations expected to be beyond instrumental capacities.

33 development of Mueller microscopes poses an instrumental challenge: the production of polarimetric p

34 Underlying clinical/instrumental characteristics progressively worsened from

35 e spray (CBS) was used to provide freedom of instrumental choice for a multiresidue panel of pesticid

36 h stroma-targeting therapy will likely be an instrumental component in treating PDA.

37 There is a dichotomy in instrumental conditioning between goal-directed actions

38 These rats then received instrumental conditioning sessions where they could pres

39 er action initiation and response rate in an instrumental conditioning task, but only when performanc

40 y factors, including laboratory temperature, instrumental conditions, and instrument platform selecti

41 urrent procedures require complex and costly instrumental configurations, we have developed a simple

42 t the brain arbitrates between Pavlovian and instrumental control by inferring which is a better pred

43 The ability to exert flexible instrumental control over one's environment is a definin

44 and Pavlovian fear, and due to a failure of instrumental control.

45 le electrochemistry-based DNA sensors reduce instrumental costs and eliminate complicated procedures,

46 o 1.17 (95% Confidence Interval 1.12, 1.22), instrumental delivery (1.14 (1.10, 1.18)), elective (1.6

47 95% CI: 0.80-5.54; I2: 90%; p-value = 0.10), instrumental delivery (5,176 FGM/C and 31,923 non-FGM/C

48 ancerous cells, block/aid apoptosis, and are instrumental/detrimental in cancer cell migration requir

49 ntification, and establishing guidelines for instrumental development answering questions on what res

50 The 95 GHz instrumental developments occurring at ACERT now enable

51 A formal index of agency, instrumental divergence allows an organism to flexibly o

52 that a measure of expected value that treats instrumental divergence as a reward surrogate provided a

53 h effects were predicted by the influence of instrumental divergence on economic choice preferences.

54 Here, using instrumental divergence, the distance between outcome di

55 g a preference for environments with greater instrumental divergence, the distance between outcome pr

56 es of 50 gasoline samples in 3 h without any instrumental drift.

57 the best to eliminate the matrix effects and instrumental drift.

58 Mendelian randomization reveals stronger instrumental estimates of DBP (OR [95% CI] = 1.20 [1.15-

59 6.4 earthquake together with historical and instrumental events supports that the AIFS is currently

60 mptoms after splenectomy, she underwent many instrumental examination, including a colonoscopy with b

61 and dryness were positively correlated with instrumental findings.

62 umbens core, shell, and caudate-putamen, are instrumental for a wide-range of functions and disorders

63 sualizing transcriptionally similar cells is instrumental for accurate exploration of the cellular di

64 We propose that this run is instrumental for bringing the mental map into register w

65 and/or accumulation within endolysosomes is instrumental for characterizing lysosome-driven pathways

66 iosynthesis in the growing cluster, which is instrumental for coordinated motion and swarming.

67 data on the E protein structure and could be instrumental for designing carbohydrate-binding antivira

68 The data are instrumental for developing a model for the biological w

69 that these network emergence dynamics may be instrumental for explaining network details, as well as

70 We believe that these data will be instrumental for helping policymakers and researchers as

71 eous complexes and replicons; hence they are instrumental for myriad cellular processes such as cell

72 modulation through prefrontal cortex appears instrumental for permitting an organism to adapt its bia

73 duces a slope, lambda (Lambda), which can be instrumental for practitioners to identify transformatio

74 These results support the view that hAEC are instrumental for regenerative medicine as well as in the

75 Traction force microscopy (TFM) has been instrumental for studying such forces, providing spatial

76 oplasmic reticulum to mitochondria, which is instrumental for the apoptotic action of the receptor.

77 e tools and printing methods that are deemed instrumental for the design of next-generation bioinks,

78 Identification of allergenic IgE epitopes is instrumental for the development of novel diagnostic and

79 microscopic assessment of tissue samples is instrumental for the diagnosis and staging of cancer, an

80 a pioneer in targeted cancer therapy and was instrumental for the discovery and deployment of the fir

81 ymes involved in epitranscriptome shaping is instrumental for the elucidation of the functional roles

82 3 and VAP, we showed that phosphorylation is instrumental for the formation of ER-endosome contacts,

83 The formation of the froth layer was instrumental for the preservation of coesite, promoting

84 ne system and the hemostatic system might be instrumental for the prevention and treatment of microva

85 ity, a thermodynamic parameter that has been instrumental for the rational design of synthetic molecu

86 Our resource is instrumental for the systematic molecular characterizati

87 EPN3-induced partial EMT is instrumental for the transition from in situ to invasive

88 ponents within the metastatic cascade may be instrumental for therapeutic discovery to curb prometast

89 izing glomerular filtration function will be instrumental for translation of organoid technology for

90 These studies are especially important as instrumental for understanding evolutionary and ecologic

91 he temporal component were considered as the instrumental function.

92 al support (giving and receiving emotional & instrumental help) before the disaster was measured usin

93 Advances in machine learning are proving instrumental, illustrated by their recent use to shed li

94 ne a rapid progress in the last years due to instrumental improvements leading to a higher sensitivit

95 E The development of chimeric SHIVs has been instrumental in advancing our understanding of HIV-host

96 maging, and correlative approaches have been instrumental in also targeting rare events inside infect

97 These early investigations have been instrumental in demonstrating short-term safety and effi

98 In vitro biochemical data have been instrumental in deriving some of the fundamental princip

99 drive immune tolerance to allergens, will be instrumental in designing therapeutic strategies to trea

100 ertebrates or mammalian cell lines, has been instrumental in discovering genes essential for neural f

101 otropically regulate cardinal nodal proteins instrumental in driving NEPC including Aurora Kinase A,

102 Electronic health records have become instrumental in effecting quality improvement innovation

103 Animal research has been instrumental in elucidating genes and circuits that adap

104 Single-molecule fluorescence has been highly instrumental in elucidating interactions and dynamics of

105 oteins, including HPV16 E6 and E7, have been instrumental in elucidating the activities of cellular s

106 Its widespread use has been instrumental in ensuring transparency in the evaluation

107 Our method will be instrumental in gaze behavior analysis by serving as a s

108 This will be instrumental in greatly expanding our knowledge of the o

109 hestration of head movements, which might be instrumental in guiding animals towards spatial targets

110 positron emission tomography (PET) has been instrumental in guiding discovery and development of CNS

111 hey correlate with clinical outcomes will be instrumental in guiding the optimal use of immune recons

112 t in RA-generating enzymes or RARs have been instrumental in identifying RA functions, revealing that

113 onstitutive Lpar1 null mutant mice have been instrumental in identifying roles for LPA-LPA(1) signali

114 ly affinity column chromatography, have been instrumental in isolating numerous lectins and glycoprot

115 n additional phase in the Polycomb mechanism instrumental in natural variation of silencing, and prov

116 nwort model species, Anthoceros agrestis, is instrumental in our efforts to better understand not onl

117 Electron microscopy has been instrumental in our understanding of complex biological

118 ating Ly6C(hi) and Ly6C(low) macrophages are instrumental in perpetuating and resolving the hepatitis

119 ir synergy with classical blocker Abs may be instrumental in potentiating immunotherapy strategies an

120 dependent phosphorylations of Spt5, a factor instrumental in promoter-proximal pausing and elongation

121 This guidance has been instrumental in promoting transparent evaluation of new

122 Drosophila models have been instrumental in providing insights into molecular mechan

123 although FCS diffusion law analysis has been instrumental in providing new insights into the membrane

124 (2) To identify factors that are instrumental in reducing the incidence of posterior caps

125 Gut microbiota and their metabolites are instrumental in regulating intestinal homeostasis.

126 This feature was instrumental in revealing the spatial specificity of int

127 pt climatic and ecological changes have been instrumental in shaping biodiversity.

128 principles in biology, growth laws have been instrumental in shaping our understanding of bacterial p

129 chronic social defeat stress model has been instrumental in shaping our understanding of neurobiolog

130 between ChINs is a robust network motif and instrumental in shaping the network activity of ChINs.

131 essment of restriction size and shape may be instrumental in studies of a wide range of porous materi

132 pid composition of meibum, making E3hom mice instrumental in studying the mechanisms of the biosynthe

133 and mysids exhibit towards one another were instrumental in subsequent mysid domestication.

134 lomeres, Rap1-interacting-factor 2 (Rif2) is instrumental in suppressing Tel1 activity.

135 The results are expected to be instrumental in the analysis, design, and operation of n

136 oimmune circuits in the tumor milieu will be instrumental in the development of novel therapeutic app

137 Bismuth-based materials have been instrumental in the development of topological physics,

138 ral synthon useful in drug discovery and was instrumental in the generation of useful SAR during a RO

139 important not only for Tau function but also instrumental in the initiation of Tau aggregation.

140 dioguided surgery, nuclear medicine has been instrumental in the realization of precision medicine.

141 RING-finger E3 ligases are instrumental in the regulation of inflammatory cascades,

142 al synthesis of this intermediate, which was instrumental in the structural and functional characteri

143 ed two-partner secretion system ExlB-ExlA is instrumental in the virulence of different Pseudomonas s

144 ntact with urban areas, can suggest settings instrumental in transmission and indicate optimal locati

145 a PLD3/4-specific biochemical assay will be instrumental in understanding better both nucleases and

146 tative trait locus (eQTL) analyses have been instrumental in understanding how thousands of single nu

147 isms of DBS, and how these studies have been instrumental in understanding PD and advancing the devel

148 This model has been instrumental in understanding the events that lead to th

149 g tests of clear conceptual models have been instrumental in understanding these patterns in both ter

150 In particular, this approach could be instrumental in validating novel MRI-based techniques to

151 The broad concept of emergence is instrumental in various of the most challenging open sci

152 BMP and TGFbeta signaling are instrumental in vascular disease such as vascular calcif

153 C dynamically controls instrumental- and non-instrumental information seeking behaviors to resolve un

154 We performed instrumental inseminations of queens, each with four dif

155 bracketing (ORM-SSB) to efficiently correct instrumental isotopic fractionation/mass bias and matrix

156 se valence-specific response tendencies bias instrumental learning across development remains poorly

157 receptors are involved in the modulation of instrumental learning biases.

158 In standard instrumental learning models, action values are updated

159 (LFPs), recorded while patients performed an instrumental learning task, showed a specific response t

160 yses indicated that the effect of PPN DBS on instrumental learning was best captured by an increase i

161 ociative memory, Pavlovian conditioning, and instrumental learning), with detailed models of their op

162 ole for PPN-mediated reward signals in human instrumental learning.

163 critical mechanism for maximizing reward is instrumental learning.

164 al ethanol exposure (GEE), we show increased instrumental lever-pressing and disruption of efficient

165 Good instrumental linearity (r(2) > 0.99) and recoveries (83.

166 The bias caused by instrumental mass discrimination was corrected for by a

167 climate changes is, however, limited because instrumental measurements are inadequate in length to ca

168 esearch has shown it may also emerge through instrumental mechanisms.

169 dues (n = 57) yielded good agreement between instrumental methods (percent differences < 20% for 73%

170 The instrumental methods yielded similar validation results,

171 n different aspects of the environment using instrumental methods.

172 Using an instrumental model of cocaine relapse, we evaluated whet

173 d associated synaptic dysfunction affords an instrumental model system for the development of therape

174 PAHs without the need for sample clean up or instrumental modifications for different matrixes.

175 Herein we describe the instrumental modifications required in a commercial GC-I

176 Across repeated exposures to instrumental music, inter-subject correlation decreased

177 l self always moved in time with the beat of instrumental music, the virtual other moved either synch

178 rief dwell times compounded with thermal and instrumental noise.

179 aking it possible to match between different instrumental observations of the same phenomenon.

180 pered by various sources of errors caused by instrumental or optical limitations such as imperfect ov

181 maintain one's moral self-image, but also by instrumental or strategic motives, in anticipation of fu

182 utra discharge to demonstrate that the early instrumental period (1956-1986 C.E.) ranks amongst the d

183 study, metabolomic fingerprinting employing instrumental platform consisting of U-HPLC-HRMS/MS was i

184 spectrometry (MALDI-TOF-MS) is the preferred instrumental platform for fingerprinting, although its p

185 ation mass spectrometry (PSI-MS) on a single instrumental platform.

186 decisions toward environments that maximize instrumental power.

187 The instrumental predictor is more flexible; it can learn va

188 e, because the additional flexibility of the instrumental predictor is not useful.

189 s known about how the BLA contributes to the instrumental pursuit of CS.

190 g both appetitive Pavlovian conditioning and instrumental pursuit of CS.SIGNIFICANCE STATEMENT Cues p

191 n paradigm cases, rationalization undermines instrumental rationality by introducing inaccuracies int

192 high precision for replicate extractions and instrumental readings.

193 vations from timescales extending beyond the instrumental record can better understand and forecast t

194 is severely underestimated by 24-38% in the instrumental record compared to previous centuries and c

195 ght," was likely more severe than any in the instrumental record including the Dust Bowl drought.

196 n variability of hurricane activity that the instrumental record is too short to address.

197 Because the instrumental record of AMV is short, long-term behavior

198 The global instrumental record of TC intensity, however, is known t

199 Instrumental records suggests that the Mexican Subductio

200 Performance-dependent (contingent) reward is instrumental, relying on an internal action-outcome mode

201 measured peak widths are still dominated by instrumental resolution.

202 They further show heightened self-paced instrumental responding for food and impaired learning o

203 for food and impaired learning of a habitual instrumental response strategy.

204 g and could not facilitate acquisition of an instrumental response, but their activation could drive

205 f these cells promoted the acquisition of an instrumental response.

206 ck could be avoided by making or withholding instrumental responses.

207 s) and littermate controls were tested in an instrumental reversal-learning paradigm to assess cognit

208 parous/rho = 0.83 for multiparous women) and instrumental (rho = 0.67) and spontaneous (rho = 0.66) v

209 Consequently, the protein plays an instrumental role in shaping the normal development of t

210 This knowledge can play an instrumental role in the design of inhibitors, such as a

211 This work highlights the instrumental role of PGK1 autophosphorylation in its act

212 and most frames, CUSP is envisioned to play instrumental roles in numerous pivotal scientific studie

213 We also review the historical and instrumental seismicity affecting this region.

214 quirement of sample pre-treatment, high cost instrumental set-up and skilled persons to operate.

215 After the optimization of the instrumental setup and the frontal chromatographic param

216 the short analysis time and the very simple instrumental setup.

217 an internal standard to correct the data for instrumental signal drift.

218 n a severe ballistic trauma without previous instrumental signs of penetrating wound and complete vis

219 these nuclei existing in LHPs as well as the instrumental simplicity.

220 enotype data in some data sets and different instrumental strength of genetic scores for different ph

221 Network members who provided greater instrumental support to the candidates were most likely

222 aining, as follows: (1) after acquisition of instrumental taking responses for alcohol; (2) after alc

223 oding during learning of a cue-action-reward instrumental task and (2) dopamine release in the nucleu

224 tingencies and the formation of habits in an instrumental task, and mimics the effects observed follo

225 ve robust responding in a previously learned instrumental task.

226 es, and impairs goal-directed learning in an instrumental task.

227 the dorsal striatum, mice were trained on an instrumental task.

228 me ionization detection (GC-FID), using this instrumental technique as an alternative to sensory anal

229 ion of HAAs, advanced extraction methods and instrumental techniques have been applied.

230 tal sulfates, and for the first time several instrumental techniques were employed to show that the c

231 specifically by the application of advanced instrumental techniques, including spectrometric, spectr

232 to that afforded by the advanced hyphenated-instrumental techniques.

233 ractions within the heterogenous TME will be instrumental to advance this promising field and enhance

234 EMENT Neuronal assemblies are believed to be instrumental to code/encode/store information.

235 dered as a bounded portion of space, perhaps instrumental to drive newborns' attention towards events

236 the intrinsic disorder and its functions are instrumental to facilitate annotation for the millions o

237 ts show that both sources of information are instrumental to get a more comprehensive view on the rel

238 ectively in virus-infected cells and will be instrumental to identify viral immune escape and to deve

239 orescence microscopes (miniscopes) have been instrumental to monitor neural signals during unrestrain

240 hematical modeling approaches that have been instrumental to obtaining various useful insights.

241 ed by language; the way we name an object is instrumental to our construal of that object as an indiv

242 and functional output across cancer types is instrumental to realize the full potential of immunother

243 ecific quantitative trait loci/genes will be instrumental to reversing the natural angle distribution

244 3 fucosyltransferases Fut3/Fut6 and Glg1 are instrumental to the formation of bone metastasis.

245 nectivity of cortical neurons are considered instrumental to the functional repertoire of the cortica

246 eta) signaling, whose inactivation is deemed instrumental to the progression of pancreatic ductal ade

247 iogenesis, suggesting that these modules are instrumental to the temporal coordination of endothelial

248 combination with functional studies, will be instrumental to uncover the remaining unknowns in the fi

249 with high spatial and temporal accuracy are instrumental to understand how the brain works.

250 ranslation initiation factors at the RTC was instrumental to visualize and demonstrate active transla

251 assessing outcome devaluation after initial instrumental training and after reversal of action-outco

252 Instrumental training elevated expression of the plastic

253 Pavlovian-to-instrumental transfer (PIT) describes the influence of c

254 and a translationally analogous Pavlovian-to-instrumental transfer behavioral task designed to assess

255 ceptor stimulation strengthened Pavlovian-to-instrumental transfer in individuals with high baseline

256 y controls completed an appetitive Pavlovian-instrumental transfer procedure.

257 behavioral procedure that combines Pavlovian-instrumental transfer with behavioral economic analysis.

258 vity to reward-predicting cues (Pavlovian-to-instrumental transfer) and flexibility of cue-outcome as

259 and differential learning rates to quantify instrumental updating have been shown to depend on conte

260 aginal births; 3% to 30% versus 1% to 7% for instrumental vaginal births; and 42% to 70% versus 50% t

261 ous vaginal deliveries (SVD) and 3 days post instrumental vaginal deliveries (IVD).

262 r trivial knowledge that carries no apparent instrumental value.

263 Instrumental variable (IV) analyses are becoming common

264 Here, we test this assertion using instrumental variable (IV) analysis that allows for caus

265 ral population of Sweden, we used two-sample instrumental variable (IV) analysis with data from 996,8

266 Application of instrumental variable analyses to RCTs suggested that ca

267 Retrospective instrumental variable analysis of Medicare claims (2012-

268 Instrumental variable analysis using differential distan

269 ational and experimental data, as well as an instrumental variable analysis.

270 We used a preference-based instrumental variable design to address unmeasured confo

271 Using instrumental variable estimation in a cohort of patients

272 Using AD-GRS as an instrumental variable for AD diagnosis, incipient AD red

273 d a son's SBP (>1 million Swedish men) as an instrumental variable for parental SBP and examined asso

274 ce to care is a common exposure and proposed instrumental variable in health research, but it is vuln

275 ants identified were subsequently used as an instrumental variable in Mendelian randomization analyse

276 In instrumental variable models, the MSSP was not associate

277 We use instrumental variable techniques and exploit the variati

278 When we used the instrumental variable to model the causal relationship b

279 trectomy utilization within each state as an instrumental variable-exploiting variation in the timing

280 Facility preference for NOAC was used as an instrumental variable.

281 ctice variation in preference for NOAC as an instrumental variable.

282 s on the validity of the genetic variants as instrumental variables (IVs).

283 TWAS applies the established principles from instrumental variables analysis and takes advantage of p

284 Instrumental variables analysis of commercially insured

285 associated with blood sucrose or fructose as instrumental variables and applied them to summary stati

286 e mendelian randomisation (MR) using genetic instrumental variables associated with 25(OH)D and calci

287 single-nucleotide polymorphisms were used as instrumental variables for alcohol consumption.

288 Our study, using genetic variants as instrumental variables for BMI, provides evidence that h

289 ed allelic score) were used to yield genetic instrumental variables for early puberty.

290 thod for selecting genetic variants as valid instrumental variables for inferring risk factors causin

291 232 091) were identified and used to define instrumental variables for smoking.

292 ve trait loci (molQTLs), can then be used as instrumental variables in a Mendelian randomization (MR)

293 an randomization using TSH index variants as instrumental variables suggests a protective effect of h

294 Here we use Mendelian randomization, an instrumental variables technique, with a two-sample desi

295 ation (MR) is the use of genetic variants as instrumental variables to infer the causal effect of a s

296 variants associated with refractive error as instrumental variables, under the assumption that the re

297 5 x 10(-8) ) in the UK Biobank were used as instrumental variables.

298 technique using germline genetic variants as instrumental variables.

299 (R(2) <= 0.001, P < 5 x 10(-8)) were used as instrumental variables.

300 n of an alpha-methylene-gamma-lactone proved instrumental, which had not found application in natural