ライフサイエンスコーパス: insult to

1 increased from a minimum at the end of brain insult to a maximum of 43 +/- 17 torr (5.7 +/- 2.3 kPa)

2 uries, yet nRT cells generally survive these insults to a greater degree than TCR cells.

3 roles in coupling hypoxic-ischemic neuronal insults to activation of p53 and hypoxic cell death.

4 mod accelerated barrier recovery after acute insults to aged and young skin.

5 ew neurons generated after the epileptogenic insult to alleviate the development of chronic seizures.

6 he data may also help to explain why genetic insults to alpha4 subunits are associated with working m

7 The results also explain why genetic insults to alpha7-nAChR would profoundly disrupt cogniti

8 in chronic HIV-1 infection is a significant insult to antimicrobial immune defenses.

9 eriments provide strong evidence for a local insult to axons in the optic nerve.

10 ophy of RGCs, whereas the second involves an insult to axons, which causes the degeneration of axon p

11 s) allele, which is known to protect against insults to axons, strongly protects against DBA/2J glauc

12 sites, venomous animals, bacteria, and other insults to barrier tissues exposed to the environment.

13 Given that transient insults to brain may lead to long-term brain damage, the

14 r cells must respond to external stimuli and insults to build, maintain, and repair the cutaneous bar

15 arated mechanisms of action: (i) an indirect insult to cell bodies, requiring the presence of Schwann

16 UV irradiation is one of the major external insults to cells and can cause skin aging and cancer.

17 s protection against a wide variety of toxic insults to cells, including cytotoxic cancer chemotherap

18 biologic basis for the syndrome is likely an insult to cerebral vascular autoregulation.

19 re key steps in the continuum from allograft insult to chronic allograft dysfunction.

20 ntribute to the transition from acute tissue insult to chronic pain and to pain conditions for which

21 rate descriptions of the underlying physical insults to complex neuron structures at the nano-meter s

22 The nature of the insult to cultures was quantified by the resazurin-reduc

23 The prolonged period from insult to death suggests that the window for successful

24 The disorder results from various insults to different areas within the developing nervous

25 Here, we investigate whether developmental insults to different cerebellar neurons constrain the ab

26 cretion and may be perturbed by diabetogenic insults to disrupt glucose homeostasis in humans.

27 is, neurons are differentially vulnerable to insults to distinct tRNA isoacceptor families.

28 age-related cognitive decline, while genetic insults to DNC proteins are commonly linked to schizophr

29 athway activated by a wide range of cellular insults to elicit innate immune defenses through the act

30 These data suggest a link between fetal insults to epigenetic modification of genes and the resu

31 Insults to ER homeostasis activate the unfolded protein

32 which 1) genetic and/or early environmental insults to excitatory signaling in layer 3 pyramidal neu

33 action per se as a fast-acting physiological insult to FGU.

34 phalopathy of prematurity employ significant insults to generate gross central nervous system abnorma

35 this deadly transition from early myocardial insult to heart failure and sudden death is a key goal f

36 rehabilitation following other neurological insults to higher cognitive systems.

37 tions by intracellular pathogens often cause insult to host cell DNA, which stimulates responses that

38 -IRF3 pathway activation links environmental insults to IL-33 induction in the skin and pancreas infl

39 well as the ability of a number of oxidative insults to induce synuclein oligomerization.

40 Reperfusion adds further insult to injury.

41 he noncoding genome can be hijacked by focal insults to its three-dimensional organization that contr

42 A variety of insults to liver cells result in a consistent pattern of

43 port that excitotoxic (N-methyl-D-aspartate) insults to mature cerebrocortical neurons activate caspa

44 plausible pathway linking external seasonal insults to mothers with thymic development in their infa

45 ld produce recurrent and cumulative ischemic insults to multiple organs, such as the brain.

46 we uncover a mechanism that bridges noxious insults to multiple phases of translational control in m

47 lead to secondary hyperalgesia triggered by insult to muscle afferents.

48 ance of Delay cells on NMDAR may explain why insults to NMDARs in schizophrenia or Alzheimer's diseas

49 Insults to nuclear DNA induce multiple response pathways

50 induced by an interaction between metabolic insult to oligodendrocytes and inflammatory mediators.

51 this feature can be used to localize soluble insults to one compartment for up to 20 h after each med

52 on is safe and can be performed with minimal insult to overall renal function.

53 ppocampal neurons were exposed to two common insults to preterm brain: transient hypoxia-ischemia (HI

54 egrity in normal cells against environmental insults to prevent disease onset, whereas in certain can

55 g to a wide variety of potentially oncogenic insults to prevent tumour development.

56 adation of the nuclear lamina upon oncogenic insults to reinforce cellular senescence.

57 ause hypoxia, cytotoxicity, and inflammatory insults to renal tubular epithelial cells (RTECs), resul

58 PCs) are often activated following bacterial insults to replenish the host hemato-immune system, but

59 Toxic, inflammatory, or hypoxic-insults to RTECs can cause systemic fluid imbalance, ele

60 d-go technique results in a massive ischemic insult to several major organ systems.

61 sms mediated by both hypertension and direct insults to target organs.

62 process, which is accelerated by an ischemic insult to the allograft.

63 A mechanical insult to the brain drastically alters the microenvironm

64 Acquired epilepsy (i.e., after an insult to the brain) is often considered to be a progres

65 nd neuronal cell death following an ischemic insult to the brain.

66 Insult to the central nervous system (CNS) induces many

67 Inflammatory insult to the colon on post-natal day 10 caused an aberr

68 We investigated whether inflammatory insult to the colons of neonatal rats induced GHS in adu

69 Inflammatory insult to the colons of rat pups leads to GHS in adult l

70 of premature birth caused by nitro-oxidative insult to the developing retinal vasculature during ther

71 xtravasated and oxidized LDL is an important insult to the diabetic retina.

72 absence of Xblm, even without any exogenous insult to the DNA, may help to explain the genesis of ch

73 ult of severe periodontal disease acts as an insult to the endothelium.

74 mpal recordings of epileptogenesis (from the insult to the first spontaneous seizure) from two labora

75 w model of PD that combines a sub-toxic MPTP insult to the G2019S-LRRK2 mutation.

76 Endotoxin causes an ischemic insult to the gallbladder similar to that seen in acalcu

77 h abdominal pain resulting from an ischaemic insult to the gastrointestinal tract.

78 demonstrate that a viral infection, a toxic insult to the gut, commensal bacteria, and a Crohn's dis

79 T/HS cause ischemic insult to the gut, resulting in the release of biologica

80 Pressure overload is a common pathological insult to the heart and the resulting hypertrophy is an

81 eckmann et al. showed that an acute ischemic insult to the heart, which induces sterile inflammation,

82 nd and persistent memory loss resulting from insult to the hippocampus in infancy becomes evident in

83 nd and persistent memory loss resulting from insult to the hippocampus in infancy was absent in early

84 hological observations suggest that a direct insult to the host vasculature may also be important.

85 defense against infection and other types of insult to the host.

86 ental disruption associated with the initial insult to the immature brain, injury processes can persi

87 de pannus invasion following an inflammatory insult to the joint.

88 that drive fibrogenesis after an initiating insult to the kidney are incompletely understood.

89 We will explore how, following a primary insult to the kidney, disturbance of purinergic balance

90 yte FGFR4 protects against acute and chronic insult to the liver and prevents accompanying fibrosis.

91 Alcohol insult to the liver sets off a complex sequence of infla

92 eroxidation were similar irrespective of the insult to the livers that resulted in fatty liver.

93 structive lung disease that follows a severe insult to the lower respiratory tract, resulting in fibr

94 ute lung injury (ALI, not caused by a direct insult to the lung) represents the first organ dysfuncti

95 t acute lung injury (ALI not due to a direct insult to the lung), the contribution of various regulat

96 Heat-shock is an acute insult to the mammalian proteome.

97 ly contributes to the cardiac injury of this insult to the myocardium.

98 enon and a manifestation of greater ischemic insult to the myocardium.

99 f suture-induced corneal neovascularization, insult to the nasal side was shown to result in more ext

100 be caused by traumatic, toxic, or metabolic insult to the nerve.

101 ollow deafening can be prevented by a second insult to the nervous system--the lesion of a basal gang

102 ve cell loss, suggesting that a time-limited insult to the nigrostriatal system can set in motion a s

103 in SS is determined by the direct autoimmune insult to the ocular surface epithelia, whereas in MGD p

104 A primary insult to the pancreatic islets of Langerhans, leading t

105 ntation is gastric aspiration, a deleterious insult to the pulmonary epithelium.

106 on of this analog up to 1h after an ischemic insult to the rat brain had a potent neuroprotective act

107 cell (RGC) loss/survival following a defined insult to the retina is a prerequisite in order to allow

108 lso protective against a subsequent ischemic insult to the same kidney, revealing that systemic uremi

109 drome may develop following a focal vascular insult to the sixth nerve trunk with axonal degeneration

110 It is particularly controversial whether an insult to the type II AEC initiates an inflammatory resp

111 tion in preclinical models through localized insult to the vascular endothelial cells.

112 us system development and after pathological insults to the adult nervous system.

113 Insults to the airway epithelium play a key role in cons

114 levels of responsiveness produced by various insults to the airway.

115 th PAMPs and DAMPs can be liberated by early insults to the allograft, including ischemia/reperfusion

116 er cognition and help to explain why genetic insults to the alpha4 subunit weaken cognitive and atten

117 cent theories which link early developmental insults to the amygdala with the ToM impairments which a

118 mical, inflammatory, mechanical or metabolic insults to the axon.

119 th genetic barrier defects and environmental insults to the barrier with AD suggests that epidermal b

120 Although insults to the blood-forming system highlight the need f

121 part of the innate immune response following insults to the body.

122 Neuroinflammation can be caused by various insults to the brain and represents an important patholo

123 A variety of potential dysglycaemic insults to the brain can cause cellular and structural i

124 Multiple insults to the brain lead to neuronal cell death, thus r

125 Microglia are also profoundly sensitive to insults to the brain to which they respond with process

126 leukin-1 (IL-1) is induced immediately after insults to the brain, and elevated levels of IL-1 have b

127 dence for a compensatory mechanism following insults to the brain, and insight into the dynamic natur

128 iving with HIV, including legacy and ongoing insults to the brain, as well as host-specific factors.

129 hanisms, including genetic and environmental insults to the brain, contribute to neurodevelopmental c

130 bolism commonly occur following a variety of insults to the brain.

131 n epileptogenic process induced by transient insults to the brain.

132 in inhibition on the BBB following traumatic insults to the brain.

133 ctive agent against neural damage by various insults to the brain.

134 of CK2 as a neuroprotectant after oxidative insults to the brain.

135 d by neuro-degenerative disease or traumatic insults to the brain.

136 Astrocytes become reactive in response to insults to the central nervous system by adopting contex

137 Chronic pain caused by insults to the CNS (central neuropathic pain) is widely

138 thesized to occur in epilepsy after acquired insults to the CNS as well.

139 nefits may be achieved for a wide variety of insults to the CNS by regulating tPA activity to preserv

140 ility of children to trauma or to infectious insults to the CNS.

141 citability disorders after injury or disease insults to the CNS.

142 white matter integrity suggesting potential insults to the cord.

143 Our data suggest that severe nutritional insults to the developing brain in utero may be capable

144 Insults to the developing cerebellum can cause motor, la

145 logical studies showing associations between insults to the developing lung during prenatal and early

146 n that fungal pathogens and yeast respond to insults to the endoplasmic reticulum (ER) by initiating

147 bles proper inflammatory response to harmful insults to the host, and increases resilience of the ent

148 e immune responses to sterile and infectious insults to the host.

149 s demonstrate that SIV produces long-lasting insults to the humoral immune system beginning very earl

150 isruption of hormones involved in sleep, and insults to the hypothalamus, brain stem, and reticular a

151 portive measures, including limiting further insults to the kidney.

152 MP fluxes are secondary to pathophysiologic insults to the liver or might reflect compensatory respo

153 d clinical disorders caused by many clinical insults to the lung or because of predispositions to lun

154 neutralize potentially harmful and frequent insults to the lung, and appropriate regulation of leuko

155 isease occurring after years of inhalational insults to the lungs, pinpointing abnormalities or disru

156 sult, at least in part, from largely unknown insults to the maternal environment.

157 expression and signaling during pathological insults to the myocardium.

158 low distinction of acute vs. remote ischemic insults to the myocardium.

159 tective effects have not been assessed after insults to the neonatal brain.

160 t of neuropathic pain, triggered by multiple insults to the nervous system, is a clinical challenge b

161 ce caused by a wide variety of exposures and insults to the oral cavity.

162 ulfatase are sufficient to accommodate acute insults to the permeability barrier.

163 of the sequelae of environmental and genetic insults to the postnatal cerebrum.

164 We determined SPN responses to two common insults to the preterm brain: hypoxia-ischemia and hypox

165 duced by mild-to-moderate severity traumatic insults to the rat spinal cord.

166 Despite this insult to their genetic integrity, these cells survive w

167 ion coupled with unique acute and persistent insults to their immune function after CAR-T-cell infusi

168 Many children who suffer insults to their lungs during the first few years of lif

169 toxicity in vitro, and mild hypoxic/ischemic insult to these mice in vivo results in significantly in

170 Insult to this pathway may underlie BBB dysfunction and

171 s a first line of defense against pathogenic insults to tissues.

172 ophies and white matter disease when further insult to tRNA metabolism is introduced.

173 ation with use of yttrium 90, inflict lethal insult to tumors while preserving normal hepatic parench