ライフサイエンスコーパス: integral membrane protein

1 ZipA (single transmembrane helix), and PgpB (integral membrane protein).

2 -terminal signal sequence, and is a type one integral membrane protein.

3 the NSm topology as a two-membrane-spanning integral membrane protein.

4 e deficient-1 (sid-1) gene, which encodes an integral membrane protein.

5 implicate this pathway in the disposal of an integral membrane protein.

6 y charged group extending from a lipid or an integral membrane protein.

7 and Tat systems in the assembly of a single integral membrane protein.

8 n physiological ligand, podoplanin, being an integral membrane protein.

9 D of the succinate dehydrogenase complex, an integral membrane protein.

10 ide-ranging effects on the phenotype of this integral membrane protein.

11 tals and high-resolution X-ray structures of integral membrane proteins.

12 r mitochondrial membrane by one, or several, integral membrane proteins.

13 modification, and deployment of secreted and integral membrane proteins.

14 luding the correct folding and expression of integral membrane proteins.

15 ns are a key element of the function of many integral membrane proteins.

16 DNP MAS ssNMR studies of lipid membranes and integral membrane proteins.

17 SRP) is essential for the biogenesis of most integral membrane proteins.

18 act as solvents and functional cofactors for integral membrane proteins.

19 The situation is different for integral membrane proteins.

20 he periplasmic AcrA, which bridges these two integral membrane proteins.

21 estigating the dynamic interactomes of human integral membrane proteins.

22 ble tool for biophysical characterization of integral membrane proteins.

23 control mechanisms for damaged or misfolded integral membrane proteins.

24 ces involved in the membrane organization of integral membrane proteins.

25 in particular to aid the characterization of integral membrane proteins.

26 t into the structural and dynamic aspects of integral membrane proteins.

27 models for other experimentally challenging integral membrane proteins.

28 purification-resistant topologically complex integral membrane proteins.

29 ermal denaturation to study the unfolding of integral membrane proteins.

30 that orchestrates the endocytic recycling of integral membrane proteins.

31 successfully optimize the HDX-MS analysis of integral membrane proteins.

32 ns, like hemagglutinin (HA), NA, and M2, are integral membrane proteins.

33 Case)) binding sequence to LIMP-2 (lysosomal integral membrane protein 2), the receptor for intracell

34 Lysosomal integral membrane protein-2 (LIMP-2/SCARB2) contributes

35 human prosurfactant protein C (proSP-C) and integral membrane protein 2B (Bri2) efficiently reduce n

36 Mutations in integral membrane protein 2B (ITM2b/BRI2) gene cause fam

37 Mutations in the Integral membrane protein 2B (ITM2b/BRI2) gene, which co

38 Translocation of secretory and integral membrane proteins across or into the ER membran

39 rom human cells yielded identification of 83 integral membrane proteins, along with 163 membrane-asso

40 ied an interaction between CtsP and CtsX, an integral membrane protein also required for transformati

41 s suggests that ADAM17 is regulated by other integral membrane proteins, although much remains to be

42 his protocol can be applied to virtually any integral membrane protein amenable to classic biophysica

43 mponent involved in flagellar trafficking of integral membrane proteins among parasitic protozoa.

44 However, lipidated polypeptides and integral membrane proteins-an important class of biomole

45 opy to refine the structure of an oligomeric integral membrane protein, Anabaena sensory rhodopsin (A

46 o operate at the TGN to confer sorting of an integral membrane protein and its ligand within the bios

47 with the outer mitochondrial membranes as an integral membrane protein and ultimately becomes associa

48 Claudins are a family of integral membrane proteins and are components of tight j

49 ernately binding to their redox partners and integral membrane proteins and exchanging electrons.

50 with cholesterol, detergents, peptides, and integral membrane proteins and formation of lipid rafts.

51 mes (MVEs) mediates the turnover of numerous integral membrane proteins and has been implicated in th

52 f membrane insertion for numerous eukaryotic integral membrane proteins and tail-anchored proteins.

53 htforward mass spectrometric measurements of integral membrane proteins and their complexes, directly

54 ver, the S subunit of ECF transporters is an integral membrane protein, and the transmembrane couplin

55 zymes in the Kennedy pathway, lipins are not integral membrane proteins, and they need to translocate

56 phorylation-dependent regulation of YAP, the integral membrane protein angiomotin (AMOT) and AMOT fam

57 from all subcellular locations, including 18 integral membrane protein antigens.

58 Canonical integral membrane proteins are attached to lipid bilayer

59 Integral membrane proteins are encoded by approximately

60 Integral membrane proteins are exposed to a complex and

61 Structural and functional properties of integral membrane proteins are often studied in detergen

62 Integral membrane proteins are studied with a number of

63 ndoplasmic reticulum (ER), newly synthesized integral membrane proteins are subject to a complex seri

64 When integral membrane proteins are visualized in detergents

65 AMP1 encodes an integral membrane protein associated with endoplasmic re

66 ess leads to toxic accumulation of misfolded integral membrane proteins at the cell surface, which ca

67 ght to nucleate from vesicles containing the integral membrane protein Atg9 (autophagy-related 9), CO

68 This includes the integral membrane protein ATP1A1, the phosphoinositide p

69 al method for the rational overexpression of integral membrane proteins based on computationally simu

70 ated with HycC and HycD, which are polytopic integral membrane proteins believed to anchor the core c

71 The integral membrane protein BlaR1 of Staphylococcus aureus

72 encoding these proteins is controlled by two integral membrane proteins, BlaR1 and MecR1, which both

73 rmally induced transitions of the 13-subunit integral membrane protein bovine cytochrome c oxidase (C

74 that GBA2 is not, as previously thought, an integral membrane protein but rather a cytosolic protein

75 iculties associated with the purification of integral membrane proteins but also due to the limited a

76 We then apply the strategy to an integral membrane protein by comparing the shapes of a p

77 We also show that quality control of integral membrane proteins by ribosome-associated comple

78 ongation of the N-terminal sequence of these integral membrane proteins can divert the nascent protei

79 Thus, integral membrane proteins can negotiate passage through

80 P-type ATPase and provides insight into how integral membrane proteins can recognize and transport p

81 lpha-amidating monooxygenase (PAM), a type I integral membrane protein, catalyze the sequential react

82 aprenyl pyrophosphate phosphatase (UppP), an integral membrane protein, catalyzes the dephosphorylati

83 nvolves insertion of the cholesterol-binding integral membrane protein caveolin-1 (Cav1) into the mem

84 functional low-oligomeric pores, which mimic integral membrane protein channels in structure.

85 The aquaporin (AQP) family of integral membrane protein channels mediate cellular wate

86 Here we compare the digestion of four integral membrane proteins-Cl(-)/H(+) exchange transport

87 Identified were two integral membrane proteins (Clmn, Nckap1) and one actin-

88 association between the cytoskeleton and the integral membrane protein compartment in the absence of

89 ne nucleotide transhydrogenase (PntAB) is an integral membrane protein complex participating in the r

90 Here we show for crystals of the integral membrane protein complex photosystem II that la

91 , the subunit stoichiometries of a series of integral membrane protein complexes, including the homom

92 Secreted and integral membrane proteins compose up to one-third of th

93 Integral membrane proteins comprise approximately 25% of

94 rs of the heme-copper oxidase superfamily of integral membrane proteins, comprising the O2-reducing,

95 ble gene domain 1 (HIGD1) proteins are small integral membrane proteins, conserved from bacteria to h

96 Alpha-helical integral membrane proteins contain conserved sequence mo

97 how that we can express methyl-labeled human integral membrane proteins cost-effectively by cell-free

98 anced bacterial growth and normal epithelial integral membrane protein degradation, highlighting the

99 e-9 in BALF and were resistant to epithelial integral membrane protein degradation, suggesting that b

100 pid bilayer are broadly understood to affect integral membrane proteins, details of these interaction

101 ppressor methodology was also applied to the integral membrane protein, diacylglycerol kinase A where

102 microsomes and demonstrate that numerous ER integral membrane proteins display RNA binding activity.

103 the superoxide-detoxifying enzyme (SodA), an integral membrane protein (DoxX), and a predicted thiol-

104 The integral membrane protein DsbB in Escherichia coli is re

105 The Dsc E3 ligase consists of five integral membrane proteins (Dsc1-Dsc5) and functionally

106 the spontaneous reconstitution of functional integral membrane proteins during the de novo synthesis

107 The DNA phage PhiX174 encodes the integral membrane protein E whose expression leads to ho

108 localization of polycystin-1 (PC1), a large integral membrane protein encoded by PKD1, underlies the

109 eptor for ribosomes that translate secretory/integral membrane protein-encoding mRNAs, but whether SE

110 ynamic interaction of AMOT with an endosomal integral membrane protein, endotubin (EDTB).

111 However, as a multisubunit, multispan, integral membrane protein, even wild type subunits of GA

112 It is also believed that CPR is an integral membrane protein exclusively.

113 nkyrin polypeptides are essential for normal integral membrane protein expression in a number of cell

114 roteome analysis of an Escherichia coli K-12 integral membrane protein extract, the MAPS method in co

115 J paramyxovirus (JPV) encodes four integral membrane proteins: F, G, SH, and transmembrane

116 We found that KOC1 is an integral membrane protein facing the cytosol and stably

117 uires its operon partner ToxS, a periplasmic integral membrane protein, for full activity.

118 id binding to the ammonia channel (AmtB), an integral membrane protein from Escherichia coli.

119 t is mediated by complexes formed from small integral membrane proteins from just two protein familie

120 retromer complex facilitates the sorting of integral membrane proteins from the endosome to the late

121 mer orchestrates the selection and export of integral membrane proteins from the endosome via retrogr

122 Most integral membrane proteins from the large CDP-alcohol ph

123 Sorting of integral membrane proteins from the trans-Golgi network

124 This suggests that the integral membrane protein FtsW forms a size-restricted p

125 Integral membrane proteins fulfil important roles in man

126 Integral membrane protein function can be modulated by t

127 Most paramyxoviruses have two integral membrane proteins: fusion protein (F) and attac

128 static pressure (HHP) on aqueous soluble and integral membrane proteins has been investigated to some

129 The interrogation of intact integral membrane proteins has long been a challenge for

130 f the function of Smoothened (Smo), a 7-pass integral membrane protein, has defied standard biochemic

131 The internal motions of integral membrane proteins have largely eluded comprehen

132 ay's major pharmaceutical drugs target human integral membrane proteins (hIMPs), only 30 hIMP structu

133 is the bottleneck for structural studies on integral membrane proteins (IMP).

134 Integral membrane proteins (IMPs) are of great biophysic

135 Integral membrane proteins (IMPs) play crucial roles in

136 ain important low-resolution information for integral membrane proteins (IMPs), challenging targets f

137 sites of hydrophobic ligand incorporation in integral membrane proteins (IMPs), where poor aqueous so

138 designed beta-strand peptides that stabilize integral membrane proteins (IMPs).

139 opportunity to compare the properties of an integral membrane protein in different artificial lipid/

140 e absence of NADPH and will transition to an integral membrane protein in the presence of stoichiomet

141 code a broadly conserved family of multipass integral membrane proteins in animals.

142 are often used to study interactions between integral membrane proteins in cellular membranes.

143 w route to exploitation of such photovoltaic integral membrane proteins in device applications.

144 The heterologous overexpression of integral membrane proteins in Escherichia coli often yie

145 systematically localize known and predicted integral membrane proteins in Saccharomyces cerevisiae t

146 The abundance of integral membrane proteins in the plasma membrane is det

147 cally suited to identify PPIs of full-length integral membrane proteins in their native membrane envi

148 of maintaining conformational epitopes from integral membrane proteins in vaccine formulations.

149 In a time where structural biochemistry of integral-membrane proteins in general still faces formid

150 While the downregulation of these integral membrane proteins, including CD81 and CD82, lik

151 er-order oligomers is a property of numerous integral membrane proteins, including ion channels, tran

152 These domains contain integral membrane proteins, including the tetraspan prot

153 transmembrane helix (TMH) of many multi-pass integral membrane proteins into the ER membrane, and it

154 vel pathway for the insertion of a subset of integral membrane proteins into the Gram-negative outer

155 oss the cytoplasmic membrane or insertion of integral membrane proteins into the phospholipid bilayer

156 Ndc1 is a highly conserved integral membrane protein involved in insertion of both

157 M2 proton channel of influenza A virus is an integral membrane protein involved in the acidification

158 sferase (MBOAT) family, a group of polytopic integral membrane proteins involved in lipid-biosyntheti

159 Rce1p and Ste24p are integral membrane proteins involved in the proteolytic m

160 receptors (GPCRs) comprise a large class of integral membrane proteins involved in the regulation of

161 This predicted integral membrane protein is essential for controlling t

162 Structure determination of mammalian integral membrane proteins is challenging due to their i

163 The aquaporin family of integral membrane proteins is composed of channels that

164 Degradation of most integral membrane proteins is directed by the endosomal

165 overning the trafficking and localization of integral membrane proteins is limited and essentially un

166 The copper transporter (Ctr) family of integral membrane proteins is ubiquitously found in euka

167 Caveolin-3 (cav-3), an integral membrane protein, is a building block of caveol

168 d raft-like domains, whereas M2, although an integral membrane protein, is not raft associated.

169 PerM, an integral membrane protein, is required for persistence o

170 atidic Acid Phosphatase type 2B (PPAP2B), an integral membrane protein known as lipid phosphate phosp

171 r membranes, and is catalyzed by a family of integral membrane proteins known as DHHC acyltransferase

172 Integral membrane proteins known as porins are the major

173 ions between Hh and Patched (Ptc), a 12-pass integral membrane protein, lead to modulation of the fun

174 The ectodomain of ephrin-B2, normally an integral membrane protein ligand, was conjugated to a so

175 The integral membrane protein LIMP-2 has been a paradigm for

176 The integral membrane protein Lit (lipoprotein intramolecula

177 The integral membrane proteins LMBD1 and ABCD4 are required

178 SCD1 is an integral membrane protein located in the endoplasmic ret

179 complexes further indicates that PSB33 is an integral membrane protein located in the vicinity of LHC

180 The thermostability of an integral membrane protein (MP) in detergent solution is

181 Integral membrane proteins (MPs) are key engineering tar

182 Integral membrane proteins (MPs) represent a class of pr

183 growing interest in studying and engineering integral membrane proteins (MPs) that play key roles in

184 m 18 different proteins, including the three integral membrane proteins Mps3, Ndc1, and Mps2.

185 Newly synthesized integral membrane proteins must traverse the aqueous cyt

186 we report a strong rheostat position in the integral membrane protein, Na(+)/taurocholate (TCA) cotr

187 the soluble protein serum albumin and to the integral membrane protein NapA shows that soluble protei

188 om lysosomes requires the cooperation of the integral membrane protein Niemann-Pick C1 (NPC1) and a s

189 H gene of Alcanivorax borkumensis encodes an integral membrane protein of the AbgT family of transpor

190 Here, we show that GAPM1a, an integral membrane protein of the alveoli, plays a role i

191 e report the first structural analysis of an integral membrane protein of the bacterial divisome.

192 The hpnN gene of B. multivorans encodes an integral membrane protein of the HpnN family of transpor

193 re used to establish that this protein is an integral membrane protein of the inner envelope, and spe

194 Mutations in the small integral membrane protein of the lysosome/late endosome

195 cillin-binding proteins (PBPs) are essential integral membrane proteins of the bacterial cytoplasmic

196 Integral membrane proteins of the divalent anion/Na(+) s

197 The integral membrane proteins of the DP1 (deleted in polypo

198 The latter contains integral membrane proteins of three sizes, collectively

199 Integral membrane proteins often present daunting challe

200 nto acceptor asparagines is catalyzed by the integral membrane protein oligosaccharyltransferase (OST

201 sequon NX(S/T) of a secreted protein by the integral membrane protein oligosaccharyltransferase.

202 dentify the interfacial sites of a trimeric, integral membrane protein, OmpF, solubilised in micelles

203 We found that two similar ER integral membrane proteins, oxysterol-binding protein (O

204 Subunit a is a 100-kDa integral membrane protein (part of V0) that possesses an

205 groups from the cytoplasm is performed by an integral membrane protein, PatA, for its transfer to pep

206 anding of the regulation and function of the integral membrane protein PEMT was improved when the enz

207 lcium pump (SERCA) is regulated by the small integral membrane proteins phospholamban (PLN) and sarco

208 endent manner via interaction with the short integral membrane proteins phospholamban (PLN) and sarco

209 ge to modulate the structural dynamics of an integral membrane protein, phospholamban (PLB), and ther

210 Integral membrane proteins play essential roles in all l

211 Sho1p, an integral membrane protein, plays a vital role in the hig

212 plit ubiquitin-based method for detection of integral membrane protein-protein interactions (PPIs) in

213 Ion mobility mass spectrometry of integral membrane proteins provides valuable insights in

214 eir performance and accuracy when applied to integral membrane proteins remained an open question.

215 mit the assembly and cellular trafficking of integral membrane proteins remains superficial.

216 Integral membrane proteins represent a large and diverse

217 elin O-acyltransferase (GOAT) is a polytopic integral membrane protein required for activation of ghr

218 pecific members of the tetraspanin family of integral membrane proteins required for morphogenesis an

219 The turnover of integral membrane proteins requires a specialized transp

220 Integral membrane proteins reside within the bilayer mem

221 the identification of 188 and 124 endogenous integral membrane proteins, respectively, some with as m

222 pled receptors (GPCRs) are a large family of integral membrane proteins responsible for cellular sign

223 eurotransmitter:sodium symporters (NSSs) are integral membrane proteins responsible for the sodium-de

224 Ion pumps are integral membrane proteins responsible for transporting

225 ontext for localizations of SpmX, a low-copy integral membrane protein sequestered by PopZ as part of

226 The human integral membrane protein SERINC5 potently restricts HIV

227 a specialized membrane domain marked by the integral membrane protein Sidekick.

228 to characterize and study ligand binding to integral membrane proteins, specifically G-protein coupl

229 Our new computational pipeline, the Integral Membrane Protein Stability Selector (IMPROvER)

230 induced radiation damage are visible in this integral membrane protein structure.

231 terior reaction chamber" is unprecedented in integral membrane protein structures.

232 racterization of the molecular properties of integral membrane proteins, such as topology and interdo

233 n meso crystallization to a broader range of integral membrane protein targets, the cubicon method sh

234 ustly predicted effects on expression of the integral membrane protein TatC for a set of 140 sequence

235 proteins work together to generate caveolae: integral membrane proteins termed caveolins and cytoplas

236 T is predicted to be an integral membrane protein that adopts an N(in)-C(out) to

237 Y is predicted to be an integral membrane protein that adopts an N-out C-in memb

238 iacylglycerol acyltransferase (DGAT)-2 is an integral membrane protein that catalyzes triacylglycerol

239 In Escherichia coli, FtsK is a large integral membrane protein that coordinates chromosome se

240 The serotonin transporter (SERT) is an integral membrane protein that exploits preexisting sodi

241 illomavirus is a short (44 amino acids long) integral membrane protein that forms homodimers.

242 or (Sigma1) is an endoplasmic reticulum (ER) integral membrane protein that is highly expressed in a

243 ial antigen of the prostate 1 (STEAP1) is an integral membrane protein that is highly up-regulated on

244 Caveolin-1 is an integral membrane protein that is the primary component

245 assays, we find that MYRF is generated as an integral membrane protein that must be processed to rele

246 P75NTR is a type I integral membrane protein that plays a key role in neuro

247 and lymphocyte protein (MAL) is a tetraspan integral membrane protein that resides in detergent-inso

248 reflected the complexities of investigating integral membrane proteins that act on a totally insolub

249 proximately 25% of eukaryotic genes code for integral membrane proteins that are assembled at the end

250 TETRASPANIN (TET) genes encode conserved integral membrane proteins that are known in animals to

251 The tetraspanins (TSPs) are a family of integral membrane proteins that are ubiquitously express

252 isaccharide transporter to the small list of integral membrane proteins that can be synthesised via i

253 ers (VITs) are a poorly understood family of integral membrane proteins that can function in iron hom

254 Glutamate transporters are integral membrane proteins that catalyse neurotransmitte

255 Dpp1 and Lpp1 are integral membrane proteins that catalyze an Mg(2+)-indep

256 DHHC-S-acyltransferases are integral membrane proteins that catalyze the addition of

257 ce-nodulation-cell division efflux pumps are integral membrane proteins that catalyze the export of s

258 Adiponectin receptors (ADIPORs) are integral membrane proteins that control glucose and lipi

259 G-protein-coupled receptors (GPCRs) are integral membrane proteins that have an essential role i

260 TMEM16A belongs to a family of integral membrane proteins that includes another CaCC, T

261 Neurotransmitter sodium symporters are integral membrane proteins that remove chemical transmit

262 t (Amt) proteins form a ubiquitous family of integral membrane proteins that specifically shuttle amm

263 eceptors (GPCRs) constitute a large group of integral membrane proteins that transduce extracellular

264 nucleoside transporters (ENTs) are polytopic integral membrane proteins that transport nucleosides an

265 rmal chemical denaturation was applied to an integral membrane protein, the A2a G-protein coupled rec

266 For integral membrane proteins, the mode of membrane associa

267 lity of the method is demonstrated with five integral membrane proteins: the beta2-adrenergic G prote

268 The biogenesis of integral membrane proteins therefore poses acute challen

269 A subset of integral membrane proteins, therefore, requires an early

270 The phagophore is largely devoid of integral membrane proteins; thus, its shape and size are

271 The translocon is composed of the two integral membrane proteins Tim23 and Tim17, each contain

272 , TaiP prevents ATG16L1 interaction with the integral membrane protein TMEM59 and allows the reroutin

273 ble protein trafficking, processes targeting integral membrane proteins to cilia are poorly understoo

274 nocytes caused defects in the trafficking of integral membrane proteins to melanosomes with substanti

275 Targeting of most integral membrane proteins to the endoplasmic reticulum

276 ld for endosomal protein complexes that sort integral membrane proteins to various cellular destinati

277 The structure of the lysosomal integral membrane protein type 2 (LIMP-2, also known as

278 The lysosomal integral membrane protein type-2 (LIMP-2) plays a pivota

279 n of its trafficking receptor, the lysosomal integral membrane protein type-2 (LIMP-2), we studied al

280 Finding a way to determine the structures of integral membrane proteins using solution nuclear magnet

281 The endoplasmic reticulum (ER) integral membrane protein VAP is a common component of M

282 tor client of the lectin chaperone vesicular integral membrane protein, VIP36.

283 the assembly factor vacuolar ATPase assembly integral membrane protein (VMA21), whose X-linked mutati

284 As all integral membrane proteins, voltage-gated ion channels a

285 SLBs and particularly the behavior of their integral membrane-proteins, we used total internal refle

286 n Azo-aided bottom-up method for analysis of integral membrane proteins, which are key drug targets a

287 Synaptotagmin 1 (Syt1) is an integral membrane protein whose phospholipid-binding tan

288 Aquaporins (AQPs) are integral membrane proteins whose function is to regulate

289 hoA fusions demonstrated it to be a bitopic, integral membrane protein with a cytoplasmic amino termi

290 Bitopic integral membrane proteins with a single transmembrane h

291 Phosphoglycosyl transferases (PGTs) are integral membrane proteins with diverse architectures th

292 ocon to block the production of secreted and integral membrane proteins with high potency.

293 oglycosyltransferases (PGTs) are families of integral membrane proteins with intriguingly diverse arc

294 te that TMTC1 and TMTC2 are both ER resident integral membrane proteins with multiple clusters of TPR

295 cleaving protease that processes many type-I integral membrane proteins within the lipid bilayer, an

296 he abundance, distribution and repertoire of integral membrane proteins within their immense, archite

297 s are transported to the cell surface by the integral membrane protein WLS (also known as Wntless, Ev

298 the rhodanese domain of the Escherichia coli integral membrane protein YgaP by NMR, X-ray crystallogr

299 solution NMR structure of the alpha-helical integral membrane protein YgaP from Escherichia coli in

300 Ste24, an integral membrane protein zinc metalloprotease, is found