ライフサイエンスコーパス: integrator

1 d to fusion of AV percepts in a multisensory integrator.

2 in the velocity input rather than within the integrator.

3 sphorylates INTS11, the catalytic subunit of Integrator.

4 ucleus (RTN), a putative CRC and chemoreflex integrator.

5 ng mediated by adhesions playing the role of integrator.

6 OVEREXPRESSION OF CO1 (SOC1), another floral integrator.

7 position signal implies participation in the integrator.

8 ortly after by repression of the SOC1 floral integrator.

9 o a CPU-based ordinary differential equation integrator.

10 lay diminished growth following depletion of Integrator.

11 olding in time is encoded via a set of leaky integrators.

12 positive and negative regulators and network integrators.

13 Despite Bridging INtegrator 1 (BIN1) being the second most statistically-

14 The bridging integrator 1 (BIN1) gene has recently been identified in

15 ciation studies have identified the bridging integrator 1 (BIN1) gene within the second most signific

16 Bridging integrator 1 (BIN1) is a T-tubule protein associated wit

17 Given that bridging integrator 1 (BIN1) organizes t-tubule microfolds and fa

18 t ADP-ribosylation factor 1 (ARF1), bridging integrator 1 (BIN1), and Rab GTPases RAB7L1 and RAB8A ar

19 athy (CNM2), caused by mutations in bridging integrator 1 (BIN1), is a mildly progressive neuromuscul

20 The Bridging integrator 1 (BIN1)/Amphiphysin/Rvs (BAR) protein family

21 protein 1-like protein 1 (NAP1L1), bridging integrator 1 (Bin1, also known as amphiphysin II), and v

22 embrane deformation protein cardiac bridging integrator 1 (cBIN1 or BIN1+13+17) creates transverse-tu

23 amphiphysin 2 (BIN1, also known as bridging integrator-1) and dynamin 2 (DNM2), two ubiquitous prote

24 d the BAR domain superfamily member bridging integrator 2 (BIN2) as an interaction partner of STIM1 a

25 tions for the N-BAR domain protein, Bridging integrator 3 (Bin3), during myogenesis in mice.

26 This direction can be dictated by their path integrator [5] but can also be set using terrestrial vis

27 The switch operates as a short-term integrator, a property that can improve the reliable con

28 In this work, we introduce Omics Integrator, a software package that takes a variety of '

29 Loss of Integrator activity, however, does not result in transcr

30 processing of HVS pre-miRNAs also depends on Integrator activity.

31 osition was imaged throughout the oculomotor integrator after saccadic or optokinetic stimulation.

32 The ICE data integrator allows users to retrieve and combine data set

33 Omics Integrator also provides an elegant framework to incorpo

34 n that emerges as a critical transcriptional integrator among pathways regulating differentiation, pr

35 response in human cells is funneled through Integrator, an RNA polymerase II-associated complex.

36 In 2002 a neural integrator, analogous to that in the ocular motor system

37 itment of RPAP2, which in turn both recruits Integrator and dephosphorylates Ser5.

38 ork of linked multipolar connectors as a key integrator and determinant of K-fiber structure and func

39 Interaction between Integrator and HVS primary miRNA (pri-miRNA) substrates

40 mTORC1 is a signal integrator and master regulator of cellular anabolic pro

41 We found that integrator and NELF, an RNA polymerase II pausing protei

42 We highlight recent molecular insights into Integrator and propose how misregulation of this complex

43 ls predict that the parameters of this leaky integrator are finely tuned through the interactions of

44 Neural integrators are involved in a variety of sensorimotor an

45 We propose Integrator as a crucial transcriptional coactivator in M

46 offers multiple deterministic and stochastic integrators, as well as tools for steady-state analysis,

47 ogates the stimulus-dependent recruitment of Integrator at immediate early genes and their enhancers.

48 ealed that these behave as phase-independent integrators at low firing rates, and switch to a phase-d

49 We find that Integrator-bound PP2A dephosphorylates the RNA Pol II C-

50 RNA cleavage by the endonuclease subunit of Integrator, but the roles of other Integrator subunits i

51 ging the activity in an impaired head neural integrator, by modulating feedback, could treat dystonia

52 are capable of inhibiting the key signaling integrator c-Abl (Abl1), resulting in massive cytopathic

53 The genetically encoded fluorescent calcium integrator calcium-modulated photoactivatable ratiobetri

54 The genetically encoded fluorescent calcium integrator calcium-modulated photoactivatable ratiobetri

55 lcium-modulated photoactivatable ratiometric integrator (CaMPARI) is a genetically encoded calcium in

56 lcium-modulated photoactivatable ratiometric integrator (CaMPARI) is a genetically encoded calcium in

57 lcium-modulated photoactivatable ratiobetric integrator (CaMPARI) reports calcium influx induced by s

58 lcium-modulated photoactivatable ratiobetric integrator (CaMPARI) reports calcium influx induced by s

59 ocessing, HVS pre-miRNA 3' end processing by Integrator can be uncoupled from transcription, enabling

60 neural network consisting of coupled neural integrators captures the neural dynamics of the experime

61 e electron microscopy, we identify potential integrator cells.

62 These studies define an integrator circuit for sleep homeostasis and provide a m

63 based on oscillatory recurrent gated neural integrator circuits (ORGaNICs), and apply it to simulate

64 er, our results suggest that attenuation via Integrator cleavage limits production of many full-lengt

65 e demonstrate that the catalytic activity of Integrator cleaves nascent capped piRNA precursors assoc

66 The Data Integrator combines columns from multiple data tracks, s

67 etal junction may act as a cortical temporal integrator, combining estimates of self-motion velocity

68 ble circuit arrangement in which an evidence integrator competes against a dynamic decision threshold

69 The metazoan Integrator complex (INT) has important functions in the

70 todes and provide evidence of a role for the Integrator complex as a terminator of promoter-proximal

71 Recently, we reported that the Integrator complex can bind paused RNA Pol II and drive

72 The Drosophila integrator complex consists of 14 subunits that associat

73 he ASCC3 subunit of the activating signal co-integrator complex is a dual-cassette Ski2-like nucleic

74 The Integrator complex is conserved across metazoans and con

75 The Integrator complex substitutes for the mRNA cleavage and

76 Integrator complex subunit 11 (IntS11) endonucleolytical

77 IntS11 forms a stable complex with Integrator complex subunit 9 (IntS9) through their C-ter

78 reduced expression of INTS3, a member of the integrator complex(3), concordant with increased stallin

79 find that Zfp609 and Nipbl interact with the Integrator complex, which functions in RNA polymerase 2

80 This revealed that the Integrator complex, which has a well-established role in

81 The host cell Integrator complex, which recognizes the snRNA 3' end pr

82 We show that the Integrator complex, which terminates snRNA transcription

83 nsiveness requires the catalytic activity of Integrator complex.

84 d1 and with the RNA Polymerase II-associated Integrator complex.

85 d Pol II can be actively destabilized by the Integrator complex.

86 Because they are key signal integrators connecting cellular processes to clinical ou

87 The light signaling integrators DE-ETIOLATED 1 and CONSTITUTIVE PHOTOMORPHOG

88 ocation in a fashion consistent with bounded integrator decision-making frameworks.

89 Integrator depletion diminishes ERK1/2 transcriptional r

90 coding genes whose expression increases upon Integrator depletion.

91 n (Lpd) functions as an important signalling integrator downstream of growth factor and axon guidance

92 tablish the Hcrt-LC connection as a critical integrator-effector circuit that regulates NREM sleep/wa

93 ments stem from a malfunctioning head neural integrator, either intrinsically or as a result of impai

94 These leaky integrators encode the Laplace transform of their input.

95 Ocular motor neural integrators ensure that eyes are held steady in straight

96 nscription, enabling new approaches to study Integrator enzymology.

97 In the absence of Integrator, eRNAs remain bound to RNAPII and their prima

98 ter assays revealed that Isl1 operates as an integrator factor, translating the density of Lhx3 or On

99 V1Delta), when incorporated into the calcium integrator FLARE, improved the signal/background ratio b

100 plified design of the calcium and light dual integrator FLARE.

101 results showed that repression of the floral integrator FLOWERING LOCUS T (FT) requires EBS.

102 iefly recapitulate the history of the neural integrator for eye movements, then further develop the i

103 nia can be predicted by deficits in a neural integrator for head motor control.

104 s, then further develop the idea of a neural integrator for head movements, and finally discuss its p

105 and that the brain RAS functions as a major integrator for RMR control through its actions at leptin

106 We propose that SPEN acts as a molecular integrator for the initiation of XCI, bridging Xist RNA

107 pport; and a new interactive tool, the "Data Integrator", for intersecting data from multiple tracks.

108 This process may be implemented in a bounded integrator framework.

109 ing by repressing GA biosynthesis as well as integrator gene expression and that, in response to indu

110 tude of clock genes and repressed the floral integrator gene FLOWERING LOCUS T1 independently of the

111 e fully explained by repressing known floral integrator genes.

112 y activating expression of a small number of integrator genes.

113 Many integrators, however, are designed as complex multicompo

114 Specifically, we applied the neural integrator hypothesis that originally was developed for

115 ke head movements consistent with the neural integrator hypothesis, except that additional sensory fe

116 lso as a direct activator of putative floral integrator/identity genes including GmSOC1, GmAP1, and G

117 n-on and RNAPII profiling reveals a role for Integrator in 3'-end cleavage of eRNA primary transcript

118 One such floral integrator in Arabidopsis (Arabidopsis thaliana) is the

119 We propose a role for Integrator in biogenesis of eRNAs and enhancer function

120 he potential for employing metabotypes as an integrator in predicting external phenotypes from genomi

121 Here we examine the requirement of Integrator in the biogenesis of transcripts derived from

122 otropin-releasing hormone (CRH) is a central integrator in the brain of endocrine and behavioral stre

123 1 (TRPV1) receptor is a polymodal molecular integrator in the pain pathway expressed in Adelta- and

124 hts into the pivotal roles of PIFs as signal integrators in regulating plant growth and development.

125 iscusses the roles of PIFs as pivotal signal integrators in regulating plant growth and development.

126 ic of LATER, implying that there must be two integrators in series.

127 that they are actively involved as cellular integrators in the control of motility and epithelial ba

128 s of cortex, casting them as one of the main integrators in the cortical column.

129 to be prominently associated with visuomotor integrators in the human cortex.

130 ive view on their putative role as metabolic integrators in the liver.

131 properties enable mitochondria to be crucial integrators in the pathways of tumorigenesis.

132 est that Piezo1 channels function as pivotal integrators in vascular biology.

133 Molecular integrators, in contrast to real-time indicators, conver

134 identified ASUN as a functional component of Integrator (INT), a multisubunit complex required for 3'

135 Integrator is a multi-subunit complex stably associated

136 Among the 14 subunits of Integrator is an RNA endonuclease that is crucial for th

137 Integrator is another RNA binding protein recruited to t

138 n a subset of these genes and confirmed that Integrator is bound to their 5' ends and negatively regu

139 Integrator is endowed with a core catalytic RNA endonucl

140 Integrator is further employed to trigger premature tran

141 Integrator is recruited to enhancers and super-enhancers

142 Integrator is recruited to the IEGs in a signal-dependen

143 The Variant Annotation Integrator is tailored to adding functional annotations

144 robust averaging is suboptimal for a perfect integrator, it paradoxically enhances performance in the

145 As expected given that neurons are nonlinear integrators, it was demonstrated that neuronal networks

146 rtantly, in contrast to the broad effects of Integrator knockdown on MAPK responsiveness, depletion o

147 Abnormal function of the ocular motor neural integrator leads to centripetal drifts of the eyes with

148 a second catalytic function associated with Integrator-mediated transcription termination and indica

149 While the contrast integrator model performed well when target elements con

150 r is in close agreement with a bounded leaky integrator model.

151 Simple integrator models can explain many aspects of such behav

152 We expand on this coupled integrator network to construct a spiking neural network

153 in the larval zebrafish by first identifying integrator neurons using two-photon calcium imaging and

154 Integrator neurons were identified as those neurons with

155 irst conclusive evidence of synapses between integrator neurons, which have long been hypothesized by

156 ein kinases (Lys111 of PDK1) functions as an integrator node to coordinate allosteric coupling of the

157 nonical NF-kappaB signaling may be a central integrator of a placental clock that governs the length

158 r of developmental processes and as a signal integrator of a wide variety of stress signals, such as

159 hlight the role of the circadian clock as an integrator of ambient abiotic stress signals important f

160 This study reveals sestrin as a central integrator of anabolic and degradative pathways preventi

161 Homer1a serves as a molecular integrator of arousal and sleep need via the wake- and s

162 entral striatum has long been proposed as an integrator of biologically significant associative infor

163 se data indicate that miR-22 functions as an integrator of Ca(2+) homeostasis and myofibrillar protei

164 ce of phosphatase, CaMKII behaves as a leaky integrator of calcium signals, a result that has been re

165 nidentified function for PDE4D as a critical integrator of cAMP/PKA and Ca(2+)/CaMKII signaling.

166 of PDF signaling suggests it is a multimodal integrator of cell autonomous clock, environmental light

167 Caspase-8 is a key integrator of cell survival and cell death decisions dur

168 ERK5 is a key integrator of cellular signal transduction, and it has b

169 karyotic initiation factor 2 (eIF2) is a key integrator of cellular stress responses and an important

170 NDVI was an effective integrator of climate and site differences in plant prod

171 One major forebrain integrator of emotional responses, the amygdala, is cons

172 rapamycin (mTOR) is emerging as an important integrator of environmental cues critical for the regula

173 cts both as a developmental signal and as an integrator of environmental cues such as drought and col

174 ant hormone abscisic acid (ABA) serves as an integrator of environmental stresses such as drought to

175 o pathway has a physiological function as an integrator of epithelial cell polarity, tissue mechanics

176 -making system to operate as a robust neural integrator of evidence.

177 myosin II (NMII) is thought to be the master integrator of force within epithelial apical junctions,

178 e intracellular Ca2+ activity as a nonlinear integrator of glutamate-dependent neuronal activity.

179 A key integrator of glutamatergic signaling in the reward circ

180 rolonged inhibition of TORC1, which is a key integrator of growth signalling.

181 ough dephosphorylation of NAC019, RCF2 is an integrator of high-temperature signal transduction and a

182 sults identify WDR5 as a critical epigenomic integrator of histone phosphorylation and methylation an

183 ber 1 (TRPV1) is known as a thermosensor and integrator of inflammation-induced hyperalgesia.

184 perceptual system and turn what should be an integrator of inputs into a bistable attractor switching

185 stable module that acts as a noise-buffering integrator of internal and external signals.

186 of the global C cycle as well as a powerful integrator of landscape-level processes.

187 Thus, the TOR kinase acts as a central integrator of light and metabolic signals and a key regu

188 TZP (Tandem Zinc-finger-Plus3), as a signal integrator of light and photoperiodic pathways in transc

189 ifies local cytoplasmic calcium as a central integrator of metabolic and proliferative signals in Dro

190 previously unidentified role as a molecular integrator of metabolic dysfunction, oxidative stress an

191 that the Wnt pathway might act as a central integrator of metabolic signals from peripheral organs t

192 o and in vivo systems to show that FoxO1, an integrator of metabolic stimuli, inhibits PPARgamma expr

193 ), a RhoA activator, is thought to act as an integrator of microtubule (MT) and actin dynamics in div

194 As an integrator of molecular pathways, mTOR (mammalian target

195 ropose that ABA acts as a coordinator and an integrator of most root responses to mild and moderate W

196 p73 as the conserved central transcriptional integrator of multiciliogenesis.

197 cate due to the physiological function as an integrator of multiple chemical, mechanical, and tempera

198 Thus, PASMC FoxO1 is a critical integrator of multiple signaling pathways driving PH, an

199 ts suggest that cMyBP-C acts as a sarcomeric integrator of multiple signaling pathways that determine

200 elongated HYPOCOTYL5 (HY5) bZIP protein, an integrator of multiple signaling pathways, also plays an

201 ly florigen, has been identified as a system integrator of numerous flowering time pathways in many s

202 , also known as STK11) tumour suppressor, an integrator of nutrient availability, metabolism and grow

203 suggest that Smed-pbx functions as a central integrator of positional information to drive patterning

204 Thus, the transcription factor TT8 is an integrator of secondary metabolism and stress response.

205 key function for this structure as a potent integrator of sensory information towards governing cons

206 As a key integrator of shoot branching, BRANCHED 1 (BRC1) coordin

207 ls and indicate that EBF1 functions as a key integrator of signal transduction, inflammation, and met

208 (also known as TNK2), has emerged as a major integrator of signaling from various receptor tyrosine k

209 get of rapamycin (mTOR) has emerged as a key integrator of signaling pathways that regulate these met

210 ein found in all three domains of life as an integrator of signals of the nitrogen and carbon balance

211 signaling network plays a central role as an integrator of signals that control cellular proliferatio

212 hese findings establish trsn as an essential integrator of sleep and metabolic state, with implicatio

213 rum should not be universally regarded as an integrator of somesthetic and motor information.

214 ng an internal state that behaves as a leaky integrator of stimulus exposure.

215 mation and establish c-di-GMP as the central integrator of Streptomyces development.

216 Collectively, RhoGEF12 acts as an integrator of stretch-induced signaling cascades in card

217 lopment that employs the promoter of RAM1 as integrator of symbiotic (transmitted via CCaMK and CYCLO

218 ment binding protein 1 (RREB1) as a critical integrator of TGF-beta and Ras signals during both devel

219 Here, we identify LRP1 as an integrator of TGFbeta1-mediated mechanisms that regulate

220 r findings identify the isoform Pparg2 as an integrator of the adipose lipid metabolism coordinating

221 A key integrator of the cell's responses to starvation and oth

222 dependent protein kinase (DNA-PK), a central integrator of the DNA damage response, which caused phos

223 an important role of PHOSPHATE2 (PHO2) as an integrator of the N availability into the PSR since the

224 Acetyl-coenzyme A (AcCoA) is a major integrator of the nutritional status at the crossroads o

225 However, a molecular integrator of the PKA response in the heart is unknown.

226 of rapamycin (mTOR) is emerging as a central integrator of these signals playing a critical role in d

227 these results highlight PKA as a biochemical integrator of three major types of GPCRs and necessitate

228 These findings reveal that Smad2 is a unique integrator of transcription and signaling events and is

229 egulator of pre-mRNA splicing and a possible integrator of transcription and splicing regulation.

230 we have identified SRC-2 as an indispensable integrator of transcriptional complexes that control the

231 C) protein 5 (CXXC5) is a critical regulator/integrator of various signaling pathways that include th

232 ry binding protein 1 and its targets are key integrators of antibody and T follicular cell responses.

233 hus reveals these core apoptosis proteins as integrators of cell death and physiology in pancreatic b

234 amine signaling pathways implicating them as integrators of central and peripheral metabolic signals

235 nct Rho GTPases may act as context-dependent integrators of chemotactic cues in directional cell migr

236 erebral endothelium can serve as sensors and integrators of CNS dysfunction, releasing measurable bio

237 Mitochondria are key integrators of convergent intracellular signaling pathwa

238 ight have general and conserved functions as integrators of deterministic genetic programs with activ

239 rs and we now recognize primary cilia as key integrators of extracellular ligand-based signaling and

240 ous sclerosis proteins TSC1 and TSC2 are key integrators of growth factor signaling.

241 ing members of the Lyn kinase subfamily (key integrators of interleukin-7 and pre-BCR signaling) and

242 se findings in the context of PIFs acting as integrators of light and other signals.

243 Cells are sophisticated integrators of mechanical stimuli that lead to physiolog

244 The TCP transcription factors usually act as integrators of multiple growth regulatory and environmen

245 TRPV1 channels in sensory neurons are integrators of painful stimuli and heat, yet how they in

246 Vagal afferent neurons are therefore early integrators of peripheral signals underling homeostatic

247 reviously unrecognized role for Th1 cells as integrators of perivascular CF and cardiac dysfunction i

248 s unveil TACs as transient but indispensable integrators of SC niche components and reveal an intrigu

249 t abundant cell type in the brain, are vital integrators of signaling and metabolism.

250 ical roles in plant biology and often act as integrators of signals from multiple plant regulatory an

251 mta1 and Camta2 that have been recognized as integrators of stress responses.

252 ons for different actions serve as important integrators of synaptic inputs from upstream centers, in

253 ntifies a circuit in which SOM cells are key integrators of vestibular and luminance signals.

254 ' end processing by enhancing recruitment of Integrator or Heat Labile Factor to snRNA or RDH genes,

255 II (RNAPII)-associated multiprotein complex, Integrator, plays a critical role in both initiation and

256 in can function autonomously, restoring full integrator processing activity when introduced into a he

257 rotein-coding genes, possibly by controlling Integrator recruitment or RNA polymerase II dynamics.

258 are functionally involved as transcriptional integrators regulating the basal expression of the deriv

259 ters containing paused RNA polymerase 2, and Integrator similarly regulates neuronal migration.

260 tive systems can be categorized as ephemeral integrators, stable loners, and anything in between.

261 Thus, blocking PP2A association with Integrator stimulates pause release and gene activity.

262 cells to identify functional domains within integrator subunit 12 (IntS12) required for snRNA 3' end

263 Here we report that Integrator subunit 8 (IntS8) is critical for transcripti

264 Although disruption of almost any integrator subunit causes snRNA misprocessing, very litt

265 interact and stabilize the putative scaffold integrator subunit, IntS1.

266 Integrator subunits 9 and 11 (IntS9/11) are thought to c

267 The molecular functions of Integrator subunits beyond the RNA endonuclease remain p

268 Functional depletion of Integrator subunits diminishes the signal-dependent indu

269 ubunit of Integrator, but the roles of other Integrator subunits in gene regulation have yet to be el

270 interaction between the largest and smallest integrator subunits that is essential for the 3' end for

271 Many noncatalytic Integrator subunits, which are largely dispensable for s

272 2 function but also abolish binding to other integrator subunits.

273 rk on the Pol II CTD and also interacts with Integrator subunits.

274 nts a functional ortholog of the central FTi integrator SUPPRESSOR OF OVEREXPRESSION OF CONSTANS1 (SO

275 Along with the florigens, the floral integrator SUPPRESSOR OF OVEREXPRESSION OF CONSTANS1 is

276 r (CaMPARI) is a genetically encoded calcium integrator that facilitates the study of neural circuits

277 r (CaMPARI) is a genetically encoded calcium integrator that facilitates the study of neural circuits

278 al tools, we have identified Akt as a signal integrator that links distinct facets of CTL differentia

279 Protein translation rates serve as the integrator that proportionally converts mitogen history

280 software tools include a Variant Annotation Integrator that returns predicted functional effects of

281 ty and postinhibitory rebound (PIR), for the integrators that are typically used.

282 discovered family of intracellular signaling integrators that serve as the conduit to the basic trans

283 ht, are specialized as near-perfect synaptic integrators that summate inputs over extended timescales

284 IT dendrites functioned as temporal integrators that were particularly responsive to dendrit

285 situs is commonly believed to be the "neural integrator" that accomplishes this function through the

286 ith this ion-sensitive moiety yields an "ion integrator" that permanently marks cells undergoing high

287 s, using a cascade of imperfect mathematical integrators, that reproduces the response to MVS (and mo

288 Integrator thus helps to shape the transcriptome and ens

289 smoothly transitions from phase independent integrator to a phase dependent mode.

290 Incorporating negative evidence allows Omics Integrator to avoid unexpressed genes and avoid being bi

291 ther suggest that RSK2 functions as a signal integrator to provide antianoikis protection to cancer c

292 rted, each of which comprises coupled neural integrators to implement normalization via recurrent amp

293 A computational model using coupled leaky integrator units with biophysically plausible assumption

294 Specifically, we present evidence that Integrator utilizes its RNA endonuclease activity to cle

295 group termed the velocity-to-position neural integrator (VPNI).

296 ium channels can implement a molecular leaky integrator, where the input signal is the membrane poten

297 found that the miR34/SNAIL module acts as an integrator while the miR200/ZEB module acts as a three-w

298 naling in spines by acting as a leaky Ca(2+) integrator with the time constant of several seconds.

299 problems in neural coding, such as neuronal integrators with irregular inputs and internal noise.

300 e required to reset any errors that the path integrator would inevitably accumulate.