ライフサイエンスコーパス: integrin beta3

1 in animals depleted of platelets or lacking integrin beta3.

2 SMC migration requires CD47 interaction with integrin beta3.

3 led by multiple molecular characteristics of integrin beta3.

4 essential regulator of the fast recycling of integrin beta3.

5 nsgenic knockin mice expressing a Pro32Pro33 integrin beta3.

6 d peptide spanning the polymorphic region of integrin beta3, 24AWCSDEALPLGSPRCD39 (LPL).

7 nts with elevated blood 5-HT levels, linking integrin beta3, 5-HT, and ASD risk.

8 ntify a role of kindlin-3 phosphorylation in integrin beta3 activation and provide a basis for functi

9 and, to a lesser extent, MSCs of the BMM and integrin beta3-AKT signaling in HSCs as at least partly

10 uired and the proliferation was mediated via integrin beta3/Akt signaling in EOMA cells.

11 an inverse correlation between the level of integrin beta3 and apoptosis (deoxynucleotidyltransferas

12 initiates the calpain-dependent cleavage of integrin beta3 and associated regulatory proteins, resul

13 ordination sites also appear to exist in the integrin beta3 and beta5 subunits.

14 that, upon activation, platelets expressing integrin beta3 and CD40L are required for protecting the

15 SiRNA knockdown of integrin beta3 and inhibition of Akt activity significan

16 ocalization microscopy (SMLM) to investigate integrin beta3 and paxillin in rat embryonic fibroblasts

17 n expression of the efferocytosis-regulating integrin-beta3 and its ligand milk fat globule-epidermal

18 also blunted the de novo renal expression of integrin-beta3 and phosphorylation of focal adhesion kin

19 binant periostin increased the expression of integrin-beta3 and the concomitant phosphorylation of fo

20 ibronectin, integrin alpha3, integrin beta1, integrin beta3, and cadherin 6.

21 increased the expression of integrin alphav, integrin beta3, and CD44 in jejunum of mouse pups (P10,

22 aling blocked the tumor-promoting effects of integrin beta3 antagonism.

23 Integrin beta3 antagonist, cilengitide, also enhanced tu

24 However, preclinical and clinical data of integrin beta3 antagonists have demonstrated no benefit

25 sprouting was inhibited by addition of anti-integrin beta3 antibody and pharmacologic inhibitors of

26 at cancer cells with high levels of FGFR and integrin beta3 are resistant to crizotinib treatment, su

27 We further identify integrin beta3 as a differentiation-induced surface prot

28 platelets support HE progression and suggest integrin beta3 as a potential target to treat HE.

29 t of VSMC with small interfering RNA against integrin beta3 as well as VSMC isolated from integrin be

30 st specific markers, such as cathepsin K and integrin beta3 at mRNA and protein levels.

31 We also found that MSA down-regulated integrin beta3 at the levels of mRNA and protein, and di

32 Thus, our findings point to a LSD1-integrin beta3 axis, conferring attributes of invasivene

33 via impairment of the BMM and the periostin/integrin beta3 axis, possibly associating with increased

34 Notably, this novel defined LSD1/integrin beta3 axis, was also detected in human lung ade

35 an antimetastatic therapy based on targeting integrin beta3 (beta3), which is selectively induced on

36 The expressions of integrin beta3, beta5, and beta6 were unaltered.

37 ree survival in breast cancer patients, with integrin beta3-binding protein (ITGB3BP), MAP3K8, NIMA-r

38 ot only by down-regulating the expression of integrin beta3 but also by disorganizing the clustering

39 A SNP in the gene encoding integrin beta3 causes a clinically important maternal-pa

40 that loss of traction force on ligand-bound integrin-beta3 causes recruitment of Dab2/clathrin, resu

41 Finally, we showed that the integrin-beta3 (CD61) signaling pathway was required for

42 We have found that the integrin beta3 chain can be phosphorylated on tyrosine r

43 Calpain inhibition blocked integrin beta3 cleavage and inactivation but not mPTP fo

44 d endocytosis, is not recruited to activated integrin-beta3 clusters on RGD-glass; however, it is rec

45 ion is inhibited on RGD-glass, Dab2 binds to integrin-beta3 clusters.

46 th Dab2 to facilitate the endocytosis of RGD-integrin-beta3 clusters.

47 We hypothesized that integrin beta3 could affect tumor immunity and evaluated

48 izotinib treatment, suggesting that FGFR and integrin beta3 could be used as predictive markers for M

49 n IgC45 domains form a complex not only with integrin beta3 CT but also, surprisingly, with the integ

50 a systematic mutational analysis of both the integrin beta3 cytoplasmic domain and beta3-endonexin to

51 plex between talin and the membrane-proximal integrin beta3 cytoplasmic domain and identify specific

52 n (G protein) Galpha13 directly bound to the integrin beta3 cytoplasmic domain and that Galpha13-inte

53 within the two conserved NXXY motifs in the integrin beta3 cytoplasmic domain blocks Syk binding.

54 rtance of the membrane-distal portion of the integrin beta3 cytoplasmic domain in bidirectional trans

55 ally exclusive but distinct sites within the integrin beta3 cytoplasmic domain in opposing waves.

56 nstructed to identify amino acids within the integrin beta3 cytoplasmic domain that regulate its abil

57 roteolytic events, including cleavage of the integrin beta3 cytoplasmic domain, coincided closely wit

58 n as well as tyrosine phosphorylation of the integrin beta3 cytoplasmic domain, the platelet FcgammaR

59 onexin, which interacts selectively with the integrin beta3 cytoplasmic domain.

60 kIgC4 and SkIgC5) are involved in binding to integrin beta3 cytoplasmic tail (CT), providing a mechan

61 hus, the direct binding of Syk kinase to the integrin beta3 cytoplasmic tail is a novel and functiona

62 C terminus did not affect its binding to the integrin beta3 cytoplasmic tail, but combined biochemica

63 All of these interactions require the integrin beta3 cytoplasmic tail.

64 ivation, which requires that Syk bind to the integrin beta3 cytoplasmic tail.

65 Suppression of integrin beta3 decreased AKT phosphorylation in SAIT301-

66 ing msuPAR2-transgenic mice with 3 different integrin beta3 deficiency models rescued msuPAR2-mediate

67 Integrin beta3-deficient B cells contributed in a slight

68 t with these findings, knockout mice lacking integrin beta3 displayed diminished platelet SERT activi

69 eceptors Flt1 and Flk1, Pdgfb, Pecam1, CD34, integrin beta3, ephrin B2, Tie2, and the noncoding RNA F

70 Dab2 binding to integrin-beta3 excludes other adhesion-related adaptor p

71 express human SERT and an activated form of integrin beta3 exhibited enhanced SERT function that coi

72 th and behavior, we intracranially implanted integrin beta3-expressing GBM cells into beta3 wild type

73 fied a variant associated with reductions in integrin beta3 expression levels that parallel our mouse

74 Thus, an improvement in integrin-beta3 function could stimulate muscle regenerat

75 timulation induced RAP1 activation in WT and integrin beta3 gene knockout (Itgb3-/-) OCs, but its eff

76 We therefore evaluated the integrin-beta3 gene (ITGB3), an integrin gene within an

77 In integrin-beta3 global KO mice, the expression of myogeni

78 either pp60c-src or integrin beta5, but not integrin beta3, have a reduced VP response to VEGF.

79 otein viral interleukin-6 (vIL-6) can induce integrin beta3 in an intracellular and paracrine manner.

80 angiogenesis, suggesting a potential role of integrin beta3 in KSHV pathogenesis and development of K

81 nd evaluated tumors in mice with deletion of integrin beta3 in macrophage lineage cells (beta3KOM).

82 To demonstrate the functional importance of integrin beta3 in promoting endothelial differentiation,

83 n alphaV antibody or a genetic deficiency of integrin beta3 in the CCL18 overexpression model signifi

84 Moreover, deletion of integrin beta3 in VSMC abolished the stretch protective

85 cell adhesion regulatory domain of the human integrin beta3, inhibited adhesion of human erythroleuke

86 In addition to FGFR3, integrin beta3 is another potential target for combinati

87 Integrin beta3 is critical for tumor invasion, neoangiog

88 and functional ablation assays indicate that integrin beta3 is critical in transduction of shape sign

89 In the arch of the aorta, we find that integrin beta3 is higher than in descending arteries.

90 els of integrin beta5, whereas expression of integrin beta3 is limited to stromal compartments and in

91 utaminase 2 (TG2) acting as a coreceptor for integrin beta3 is required for proper phagocytosis of ap

92 The polymorphic residue 33 of integrin beta3 is responsible for both a B cell response

93 Human platelet Ag (HPA)-1a, located on integrin beta3, is the main target for alloantibodies re

94 ear translocation, synaptopodin degradation, integrin beta3 (ITGB3) activation, and actin fiber loss,

95 tudies have shown that the expression of the integrin beta3 (ITGB3) subunit is induced upon KSHV infe

96 with cell-extracellular matrix interactions, integrin beta3 (Itgb3), integrin beta5 (Itgb5), and fibr

97 nce to radiation increases the expression of integrin beta3 (ITGB3), which promotes enhanced migratio

98 chemokine C-X3-C motif ligand 1 (CX3CL1) and integrin beta3 (ITGB3).

99 as associated with reduced expression of the integrin-beta3 (Itgbeta3) subunit.

100 integrin beta3 as well as VSMC isolated from integrin beta3 knock-out mice.

101 The mechanism for these responses in integrin-beta3 KO mice included an infiltration of macro

102 e, transplantation of bone marrow cells from integrin-beta3 KO mice into WT mice led to suppression o

103 hiatric disorders.SIGNIFICANCE STATEMENT The integrin beta3 Leu33Pro coding polymorphism has been ass

104 A common isoform of integrin beta3, Leu33Pro is associated with enhanced pla

105 mutant mice and SVAS patients have enhanced integrin beta3 levels, activation, and downstream signal

106 Blockade of dominant SMC integrin (beta3)-matrix interactions may be a valuable a

107 many single-factor ECMs, in part through an integrin beta3-mediated pathway.

108 Thus, integrin beta3-mediated signaling in SMCs links elastin

109 hort of TB patients, significantly increased integrin beta3 mRNA accumulation in induced sputum was d

110 In the arteries of integrin beta3 null mice, there were lower levels of PIN

111 ning collagen peptide that selectively binds integrin beta3 on ovarian tumor cells enhances the phosp

112 RNA and protein, and disrupted clustering of integrin beta3 on the cell surface.

113 The human integrin beta3 participates in a wide range of adhesive

114 elated to a recently described non-canonical integrin beta3 pathway, were significantly downregulated

115 Our results demonstrate that integrin-beta3 plays a fundamental role in muscle regene

116 r overexpression of either integrin beta1 or integrin beta3 prevented its down-regulation.

117 rtments within the synapse, disrupted by the integrin beta3 Pro33 mutation, is critical for appropria

118 ro, we confirmed that M2 macrophages lacking integrin-beta3 produced more TGF-beta1.

119 responsible for this, the authors found that integrin beta3 promoted glutamine metabolism and oxidati

120 hat the Pro33 coding variation in the murine integrin beta3 recapitulates the sex-dependent neurochem

121 les, and hence important for RAB4A-dependent integrin beta3 recycling to plasma membrane.

122 Integrin beta3 regulates cell polarity and migration whe

123 f CD8(+) T cells, macrophages, or macrophage integrin beta3 signaling blocked the tumor-promoting eff

124 During IFNgamma stimulation, integrin beta3 signaling enhanced STAT1-mediated gene ex

125 e feedback loop in M2 myeloid cells, wherein integrin beta3 signaling favored STAT1 activation, an M1

126 These findings show that integrin beta3 signaling intensifies the suppressive eff

127 Integrin beta3 signaling maintains HSCs within the niche

128 ion in the presence of IFNgamma and impaired integrin beta3 signaling mitigated IFNgamma-dependent ne

129 curs in a tension-independent manner through integrin beta3 signaling pathway in human kidney podocyt

130 adhesion kinase and AKT, known mediators of integrin-beta3 signaling that affect cell motility and s

131 cyte damage through downstream activation of integrin-beta3 signaling.

132 educed SERT function indicate that decreased integrin beta3 subunit expression scales down the popula

133 sequences of haploinsufficiency in the mouse integrin beta3 subunit gene (Itgb3) on SERT function and

134 we report that the cytoplasmic domain of the integrin beta3 subunit is a target for limited proteolys

135 Leu33Pro amino acid polymorphism within the integrin beta3 subunit is responsible for generating the

136 titution in the second disulfide loop of the integrin beta3 subunit of the fibrinogen receptor, alpha

137 eptifibatide-dependent antibodies engage the integrin beta3 subunit such that FcgammaRIIa and its dow

138 eotide substitution in the gene encoding the integrin beta3 subunit that resulted in an Arg724Ter mut

139 the Pl(A2) alloantigen form (Pro(33)) of the integrin beta3 subunit was subcloned into this construct

140 of evidence link the ITGB3 gene encoding the integrin beta3 subunit with the serotonin (5-HT) system,

141 e CD47/integrin-associated protein(IAP), the integrin beta3 subunit, and the alpha(v)beta3 integrin c

142 inhibited the purification of CD47/IAP, the integrin beta3 subunit, and the alpha(v)beta3 integrin c

143 protein containing residues P688-T762 of the integrin beta3 subunit, encompassing its transmembrane a

144 We have identified a novel integrin beta3 subunit, termed beta3C, from a human oste

145 sional model of the homologous region in the integrin beta3 subunit.

146 f European descent is HPA-1a, located on the integrin beta3 subunit.

147 d interaction motifs in the TM domain of the integrin beta3-subunit.

148 a13 interacts with the cytoplasmic domain of integrin beta3 subunits in platelets via a conserved ExE

149 combination of an Arg and Thr residue in the integrin beta3 tail control the binding specificity for

150 solated subdomains bound specifically to the integrin beta3 tail.

151 Similar interactions were observed for integrin beta3 tails.

152 ir properties and identified the cooperative integrin-beta3-TGFbeta signaling axis as a potential the

153 In this study we identified regions on integrin beta3 that control 7E3 binding.

154 These results suggest that effects of integrin beta3 therapies on immune cells should be consi

155 In this paper, we used membrane-embedded integrin beta3 TMDs bearing environmentally sensitive fl

156 or containing a cDNA cassette encoding human integrin beta3 to restore integrin alphaIIbbeta3 on the

157 re found to alter the lipid embedding of the integrin beta3 transmembrane domain (TMD) and subsequent

158 The expression density of integrin beta3 was determined by immunohistochemistry on

159 that the extracellular matrix (ECM) receptor integrin beta3 was upregulated in lung cancer cells in r

160 Following muscle injury, integrin-beta3 was initially expressed, mainly in macrop

161 Notably, periostin and integrin-beta3 were highly colocalized in biopsy specime

162 but also by disorganizing the clustering of integrin beta3, which further inhibited the phosphorylat

163 ronectin, fibulin-2, tropomyosin (Tpm1), and integrin-beta3, which play critical roles in matrix depo