ライフサイエンスコーパス: integrin-linked kinase

1 ypes to produce collagen IV to activate ILK (integrin-linked kinase).

2 PI 3-kinase, and the Ca2+-independent MLCK, integrin-linked kinase.

3 ion of tensin requires integrins, talin, and integrin-linked kinase.

4 of Akt, which was dependent on the upstream integrin-linked kinase.

5 promotes hMSC spreading via up-regulation of integrin-linked kinase.

6 aling kinases focal adhesion kinase (FAK) or integrin-linked kinase.

7 to promote GSK3beta phosphorylation through integrin-linked kinase.

8 pathway involving annexin A2/CD11b-mediated integrin-linked kinase.

9 to produce fibronectin, which then activates integrin-linked kinase 1 (ILK-1) via alpha4-integrins.

10 ing a yeast two-hybrid screen, we identified integrin-linked kinase 1 (ILK1) as a novel PELP1-binding

11 d secretion of fibronectin that up-regulated integrin-linked kinase 1 (ILK1).

12 I3K, phosphoinositide-dependent kinase-1 and integrin-linked kinase-1 (ILK1).

13 n, to stabilize focal adhesions and activate integrin-linked kinase-1 and phospho Akt.

14 levels of PDGF-AA, platelet glycoprotein VI, integrin-linked kinase-1, high mobility group box-1 prot

15 e Raf-like MAP kinase kinase kinase (MAPKKK) INTEGRIN-LINKED KINASE 5 (ILK5) on serine 192 in the pre

16 Ang1-256 increased integrin-linked kinase, a key regulator of integrin sign

17 Blockade of FAK, but not integrin-linked kinase, abolished the tPA-triggered extr

18 SPARC exhibit diminished fibronectin-induced integrin-linked kinase activation and integrin-linked ki

19 ull fibroblasts restores fibronectin-induced integrin-linked kinase activation, downstream signaling,

20 ollowing maspin treatment revealed increased integrin-linked kinase activities and phosphorylated FAK

21 iphosphate with the subsequent inhibition of integrin-linked kinase activity and serine-473 phosphory

22 The integrin-linked kinase activity is involved in transduci

23 Loss of Parvin-beta contributes to increased integrin-linked kinase activity, cell-matrix adhesion, a

24 leads to decreased focal adhesion kinase and integrin-linked kinase activity, which impairs downstrea

25 tion, we show that MMAC1 expression inhibits integrin-linked kinase activity.

26 Furthermore, secreted SPARC activated the integrin-linked kinase/AKT (ILK/AKT) pathway, likely via

27 of glomerular failure, regulates the PINCH-1-integrin-linked kinase-alpha-parvin (PIP) complex format

28 y, using global RNA profiling, we identified integrin-linked kinase and associated cytoskeletal remod

29 presented, including smooth muscle-specific integrin-linked kinase and endothelial-specific focal ad

30 These proteins map to novel pathways such as integrin-linked kinase and IL-8 signaling and previously

31 s to focal adhesions where it interacts with integrin-linked kinase and is involved in linking integr

32 lation and decreased phosphorylation of both integrin-linked kinase and protein kinase B/Akt at its S

33 osphorylation at both Ser(19) and Thr(18) by integrin-linked kinase and/or zipper-interacting protein

34 ry protein complex that consists of PINCH-1, integrin-linked kinase, and alpha-parvin, cytoplasmic co

35 Actopaxin (alpha-parvin) is a paxillin, integrin-linked kinase, and F-actin binding focal adhesi

36 molog gene family member A, Cdc42, integrin, integrin-linked kinase, and vascular endothelial growth

37 the constitutive androstane receptor and the integrin-linked kinase are dysregulated in the myostatin

38 eta-integrin), UNC-112 (kindlin), and PAT-4 (integrin-linked kinase) are associated with these struct

39 By phage display, we identify integrin-linked kinase as a potential binding partner of

40 tably, we discovered that ILKAP encoding the integrin-linked kinase-associated serine/threonine phosp

41 cal adhesions requires both the paxillin and integrin-linked kinase binding sites and that paxillin i

42 xia through a mechanism that is dependent on integrin-linked kinase but is independent of focal adhes

43 th the inactivating lysine mutation restores integrin-linked kinase dependent phosphorylation of seri

44 nduced integrin-linked kinase activation and integrin-linked kinase-dependent cell-contractile signal

45 These data strongly suggest that integrin-linked kinase does not possess serine-473 kinas

46 egrin engagement, focal adhesion kinase, and integrin-linked kinase, enhanced insulin sensitivity and

47 tes, in contrast to controls, showed reduced integrin-linked kinase expression both at baseline and a

48 on occurred concomitantly with a decrease in integrin-linked kinase expression but with no change in

49 ith substantial increases in Akt(Ser473) and integrin-linked kinase expression, both of which promote

50 m-like cells (CSC) through modulation of the integrin-linked kinase ILK.

51 e of Blood, Margraf et al selectively delete integrin linked kinase (ILK) in myeloid cells of mice to

52 The integrin linked kinase (ILK) is a downstream mediator of

53 TB4 suppression down-regulated both integrin linked kinase (ILK), an activator of smoothened

54 s found that the cellular levels of PINCH-1, integrin linked kinase (ILK), and alpha-parvin, cytoplas

55 Pharmacological inhibition of integrin linked kinase (ILK), EGFR and NF-kappaB, as wel

56 y contact grommets at anchorages mediated by integrin linked kinase (ILK).

57 rentiation in animals lacking hepatocellular Integrin Linked Kinase (ILK).

58 Here, we report that integrin-linked kinase (ILK) (involved in transmission o

59 s associated with the down-regulation of the integrin-linked kinase (ILK) activity.

60 thway governing FLP lifetime, which involves integrin-linked kinase (ILK) and beta-parvin, two integr

61 Integrin-linked kinase (ILK) and caveolin-1 (cav-1) are

62 on protein that forms a ternary complex with integrin-linked kinase (ILK) and CH-ILKBP/actopaxin/alph

63 Integrin-linked kinase (ILK) and estrogen receptor (ER)-

64 nt and variants of uncertain significance in integrin-linked kinase (ILK) and filamin-C (FLNC).

65 mal beta1-integrin signalling intermediates, integrin-linked kinase (ILK) and focal adhesion kinase (

66 negative breast cancer revealed that loss of integrin-linked kinase (ILK) and its binding partners al

67 have revealed important roles of cytoplasmic integrin-linked kinase (ILK) and its interactive protein

68 ed p-AKT activity results from repression of integrin-linked kinase (ILK) and phosphoinositide-depend

69 ELMO2 can simultaneously bind integrin-linked kinase (ILK) and RhoG, forming tripartit

70 transduction pathways such as TGFbeta/Smad, integrin-linked kinase (ILK) and Wnt/beta-catenin signal

71 We identify the integrin-linked kinase (ILK) as a new partner for ADAM12

72 roteome and have identified septin-5 and the integrin-linked kinase (ILK) as novel calpain substrates

73 RNA sequencing profiling identified integrin-linked kinase (ILK) as the most upregulated pat

74 activation of the integrin effector protein integrin-linked kinase (ILK) at Ser246.

75 In this study, we showed that integrin-linked kinase (ILK) binds with miniature chromo

76 showed that the N-terminus of myopodin binds integrin-linked kinase (ILK) both in vivo and in vitro.

77 moted the recruitment and phosphorylation of integrin-linked kinase (ILK) by TGFBR1.

78 complex components beta-integrin, PINCH, and integrin-linked kinase (ILK) caused formation of multinu

79 and functions as a component of the integrin-integrin-linked kinase (ILK) complex.

80 Integrin-linked kinase (ILK) directly interacts with bet

81 Kidney AE1 (kAE1), PDLIM5 and integrin-linked kinase (ILK) form a multiprotein complex

82 nt, which encodes a nonsense mutation in the integrin-linked kinase (ilk) gene.

83 Integrin-linked kinase (ILK) has been implicated in podo

84 Integrin-linked kinase (ILK) has been implicated in the

85 that endothelial cell-specific depletion of integrin-linked kinase (ILK) in mouse embryos hyper-acti

86 In this article, we show that expression of integrin-linked kinase (ILK) in myeloid cells is critica

87 t assembly and facilitates Tbeta4 binding to integrin-linked kinase (ILK) in the lamellipodia.

88 Here we show that genetic deletion of integrin-linked kinase (ILK) increases NSPC proliferatio

89 Integrin-linked kinase (ILK) is a cell-ECM-adhesion comp

90 SignificanceThe pseudokinase integrin-linked kinase (ILK) is a central component of f

91 Integrin-linked kinase (ILK) is a cytoplasmic effector o

92 Integrin-linked kinase (ILK) is a distinct intracellular

93 Integrin-linked kinase (ILK) is a downstream integrin si

94 Integrin-linked kinase (ILK) is a major structural adapt

95 Integrin-linked kinase (ILK) is a mediator of aggressive

96 The integrin-linked kinase (ILK) is a multidomain focal adhe

97 Integrin-linked kinase (ILK) is a multidomain focal adhe

98 Integrin-linked kinase (ILK) is a multidomain protein th

99 Integrin-linked kinase (ILK) is a multifunctional intrac

100 Integrin-linked kinase (ILK) is a newly identified serin

101 Integrin-linked kinase (ILK) is a phosphoinositide 3-kin

102 Integrin-linked kinase (ILK) is a phosphorylated protein

103 Integrin-linked kinase (ILK) is a protein that plays imp

104 Integrin-linked kinase (ILK) is a recently identified in

105 Integrin-linked kinase (Ilk) is a scaffold and kinase th

106 Integrin-linked kinase (ILK) is a scaffold protein that

107 SIGNIFICANCE STATEMENT: Integrin-linked kinase (ILK) is a scaffolding protein in

108 Integrin-linked kinase (ILK) is a serine-threonine kinas

109 Integrin-linked kinase (Ilk) is a serine/threonine kinas

110 Integrin-linked kinase (ILK) is a serine/threonine kinas

111 Integrin-linked kinase (ILK) is a serine/threonine kinas

112 Integrin-linked kinase (ILK) is a ubiquitously expressed

113 Integrin-linked kinase (ILK) is an important component o

114 Here we demonstrate that integrin-linked kinase (ILK) is an important driver of E

115 Integrin-linked kinase (ILK) is an important protein tha

116 Integrin-linked kinase (ILK) is an intracellular scaffol

117 Integrin-linked kinase (ILK) is an intracellular serine/

118 Integrin-linked kinase (ILK) is associated with the beta

119 rs of shear stress in endothelial cells, and integrin-linked kinase (ILK) is important for blood vess

120 that the cellextracellular signaling protein integrin-linked kinase (ILK) is important in transducing

121 Integrin-linked kinase (ILK) is one of the few evolution

122 Here, we show that integrin-linked kinase (ILK) is required for the formati

123 F decreased adhesion to vitronectin, whereas integrin-linked kinase (ILK) kinase activity was down-re

124 ltiple functions including regulation of the integrin-linked kinase (ILK) level, cell shape, and surv

125 Integrin-linked kinase (ILK) localizes to focal adhesion

126 LIMD2 bound directly to the kinase domain of integrin-linked kinase (ILK) near the active site and st

127 closely linked to genes in the integrin and integrin-linked kinase (ILK) pathways and that these gen

128 Integrin-linked kinase (ILK) plays a pivotal role in con

129 Here we demonstrate that integrin-linked kinase (ILK) plays an important role in

130 Integrin-linked kinase (ILK) represents a relevant targe

131 Fn1 activity focal adhesion kinase (FAK) and integrin-linked kinase (ILK) reveals that FAK, but not I

132 ons were associated with increased levels of integrin-linked kinase (ILK) signaling as demonstrated b

133 n, regulation of the antiviral response, and integrin-linked kinase (ILK) signaling were among the to

134 Furthermore, PAR-2, through integrin-linked kinase (ILK) signaling, including the p-

135 e is mediated by integrins, the relevance of integrin-linked kinase (ILK) signals in podocyte dysfunc

136 e extracellular matrix-cell adhesion protein integrin-linked kinase (ILK) stimulates phenotypic plast

137 ity of glioma cells acting through activated integrin-linked kinase (ILK) to stimulate beta-catenin-T

138 Mammalian integrin-linked kinase (ILK) was identified in a yeast t

139 ERK pathways, and an enhanced interaction of integrin-linked kinase (ILK) with the adaptor protein Gr

140 Here we show that integrin-linked kinase (ILK), a 59-kDa serine-threonine

141 We hypothesized that integrin-linked kinase (ILK), a beta-integrin-binding sc

142 have previously shown that the expression of integrin-linked kinase (ILK), a cytoplasmic component of

143 Furthermore, inhibition of the integrin-linked kinase (ILK), a downstream effector of b

144 Here, we show that integrin-linked kinase (ILK), a mediator of cell-matrix

145 We report here that overexpression of integrin-linked kinase (ILK), a newly identified serine/

146 ted the regulation of these processes by the integrin-linked kinase (ILK), a scaffold protein that li

147 SPARC enhanced signaling by integrin-linked kinase (ILK), a serine/threonine kinase

148 Integrin-linked kinase (ILK), a serine/threonine protein

149 alpha-Catulin interacted with integrin-linked kinase (ILK), a serine/threonine protein

150 We show here that integrin-linked kinase (ILK), an intracellular integrin-

151 CH-1 is an adaptor protein that binds to the integrin-linked kinase (ILK), an intracellular serine/th

152 ort here that PINCH is a binding protein for integrin-linked kinase (ILK), an intracellular serine/th

153 otein platforms, which include integrins and integrin-linked kinase (ILK), are critical for hair foll

154 containing serine-threonine protein kinase, integrin-linked kinase (ILK), binds to the cytoplasmic d

155 al migration through a pathway that requires integrin-linked kinase (ILK), Engulfment and Cell Motili

156 matrix metalloproteinase-2, fibronectin, and integrin-linked kinase (ILK), indicating its inability t

157 Signalling is mediated by integrin-linked kinase (ILK), leading to modulation of g

158 actor (BDNF), the expression and activity of integrin-linked kinase (ILK), level of protein kinase B

159 Integrin-linked kinase (ILK), phosphoinositide-dependent

160 The heterotrimeric complex between integrin-linked kinase (ILK), PINCH, and parvin is an es

161 a telangiectasia mutated (ATM) gene product, integrin-linked kinase (ILK), protein kinase Calpha (PKC

162 4 formed a functional complex with PINCH and integrin-linked kinase (ILK), resulting in activation of

163 Here, we show that integrin-linked kinase (ILK), the crucial signal transdu

164 The LIM1 domain of PINCH interacts with integrin-linked kinase (ILK), thereby mediating focal ad

165 To characterize better the function of integrin-linked kinase (ILK), we examined the phenotypic

166 ivating surfaces stimulate Akt signaling via integrin-linked kinase (ILK), which is antagonistic to e

167 In this study we demonstrate that integrin-linked kinase (ILK), which is involved in trans

168 lf5 regulates keratinocyte migration via the integrin-linked kinase (ILK), which, like Klf5, is local

169 -binding protein revealed 100% identity with integrin-linked kinase (ILK)-1, a serine/threonine kinas

170 pectively), two structurally closely related integrin-linked kinase (ILK)-binding focal adhesion prot

171 ere that calponin homology domain-containing integrin-linked kinase (ILK)-binding protein (CH-ILKBP),

172 and fibronectin fibrillogenesis via Src- and integrin-linked kinase (ILK)-dependent signaling.

173 The integrin-linked kinase (ILK)-PINCH-parvin (IPP) complex

174 AKT, an event which required the presence of integrin-linked kinase (ILK).

175 und that PGE(2) stimulates the expression of integrin-linked kinase (ILK).

176 critically on the tight binding of PINCH to integrin-linked kinase (ILK).

177 contributes to mitogenesis via activation of Integrin-Linked Kinase (ILK).

178 -3 activation through elevated expression of integrin-linked kinase (ILK).

179 mic kinases, focal adhesion kinase (FAK) and integrin-linked kinase (ILK).

180 s for phosphoinositide 3-kinase activity and integrin-linked kinase (ILK).

181 y five LIM domains, as a binding protein for integrin-linked kinase (ILK).

182 g protein actopaxin and the serine/threonine integrin-linked kinase (ILK).

183 ts (beta(1) , beta(3) , beta(5) ) as well as integrin-linked kinase (ILK).

184 s, we hypothesised that it may interact with integrin-linked kinase (ILK).

185 along with the reported kAE1-binding protein integrin-linked kinase (ILK).

186 organs through the alpha(5)beta(1) integrin/integrin-linked kinase (ILK)/Akt pathway.

187 r cells through the alpha(5)beta(1) integrin/integrin-linked kinase (ILK)/Akt, GSK-3beta/Snail/E-cadh

188 similarity to the dominant negative form of integrin-linked kinase (ILK); i.e., viral ORF119L lacks

189 actor receptor bound protein 10 (GRB10), and integrin-linked kinase (ILK)] were significantly associa

190 The integrin-linked kinase, ILK, is also essential for integ

191 y, and suggest a novel critical role of this integrin-linked kinase in cell growth, cell survival, an

192 ike receptor 9-mediated AKT activation in an integrin-linked kinase-independent manner.

193 migratory potential when treated with either integrin-linked kinase inhibitor or Rac1 inhibitor, or b

194 or FAK inhibitor, but not beta1 integrin or integrin-linked kinase inhibitor, prevented cue-induced

195 changes in microtubule interactions with the integrin-linked kinase-integrin-beta1 axis contributed t

196 ces from different species demonstrates that integrin-linked kinase is not a typical protein kinase a

197 th altered function of alpha3beta1 integrin, integrin-linked kinase, laminin-521, and alpha-actinin 4

198 Furthermore, inhibition of integrin-linked kinase led to a decrease in phosphorylat

199 The median HSP90, HSP70, and integrin-linked kinase levels were 87.5% (n = 14), 124%

200 artments, whereas the activation of the PI3K-integrin-linked kinase-matrix metalloproteinase 2 pathwa

201 n implicated in mediating EMT, in which Smad/integrin-linked kinase may play a central role.

202 s necessary for its activation, possibly via integrin-linked kinase-mediated phosphorylation of Ser-4

203 uding talin, alpha-actinin, filamin, tensin, integrin-linked kinase, melusin, and skelemin.

204 In contrast, integrin-linked kinase mutated in a lysine residue criti

205 ition, autophagy was decreased downstream of integrin-linked kinase on stiff substrata.

206 Blocking the activity of integrin-linked kinase or protein kinase C mu either by

207 ockdown of the downstream effector of CD11b, integrin-linked kinase, or disruption of its engagement

208 omologue, phosphoinositide-dependent kinase, integrin-linked kinase, or phospho-Akt were detected in

209 Mechanistically, Integrin-Linked Kinase packaged in sEV(HYP) via HIF1alph

210 d to LIM1 of PINCH1, a core component of the integrin-linked kinase-parvin-pinch complex.

211 plex that includes UNC-112 (kindlin), PAT-4 (integrin-linked kinase), PAT-6 (alpha-parvin/actopaxin),

212 ions were found in genes associated with the integrin-linked kinase pathway, including MYH9 and RHOA.

213 Drosophila have revealed the essential role integrin-linked kinase plays in integrin adhesion - but

214 system we show that expression of wild-type integrin-linked kinase promotes the wortmannin sensitive

215 (1) and resultant inhibition of the integrin/integrin-linked kinase/protein kinase B/Akt signaling pa

216 Integrin-linked kinase reportedly phophorylates serine-4

217 as a potential host antiviral response, and integrin-linked kinase signaling as an entry factor.

218 , and inflammation, especially NF-kappaB and integrin-linked kinase signaling pathways.

219 with PINCH, a LIM-only protein implicated in integrin-linked kinase signaling.

220 A CRISPR-Cas9 screen reveals that loss of integrin-linked kinase synergizes with SRC inhibition, p

221 ead to maintain barrier function and recruit integrin-linked kinase to adhesion sites, which leads to

222 d CXCR2-driven protein kinase C mu-dependent integrin-linked kinase to be essential for CXCL1-mediate

223 The activity of integrin-linked kinase was required for the effect of SP

224 mong differentially expressed proteins, ILK (integrin-linked kinase) was highly enriched in both IL-1

225 , paxillin, focal adhesion kinase (FAK), and integrin-linked kinase were not recruited to adhesion si

226 hese LNAI cells show increased expression of integrin-linked kinase, which is putatively responsible