ライフサイエンスコーパス: interactome

1 trometry (XL-MS) can confirm and extend this interactome.

2 ch to map resulting changes in the molecular interactome.

3 t strategy of iron uptake, were part of this interactome.

4 drugs that target any of the proteins in the interactome.

5 of the cell also has a large effect on Src's interactome.

6 involved in the regulation of the human SH3 interactome.

7 or specific manipulation of the methyllysine interactome.

8 rationale that could be applied to an entire interactome.

9 using the APEX enzyme to interrogate the RC interactome.

10 s of a recently published SARS-CoV-2 protein interactome.

11 e experimental efforts to complete the human interactome.

12 d mass spectrometry to identify the STEP(61) interactome.

13 spectrometry (MS), to define the potato ATG8 interactome.

14 physical interacting proteins in Arabidopsis interactome.

15 NA repair are enriched in the potential TCTP interactome.

16 methylation (DNAm) alterations onto a human interactome.

17 1 binding to the genome and altered the ESR1 interactome.

18 ng motifs and cellular function, that is, an interactome.

19 significant fraction of the protein-protein interactome.

20 NA library to identify the cardiac dysbindin interactome.

21 the triazole-based probes in the study of Ub interactome.

22 b were significantly decreased in the embryo interactome.

23 dscape and change the wiring of the promoter interactome.

24 anscriptomics, and proteomics into the human interactome.

25 stematic extracellular protein map, the IgSF interactome.

26 9 viral and cellular proteins within the Zta interactome.

27 teractome and compared it to the known ovary interactome.

28 ems biology approach, we built a MB-specific interactome.

29 tudy was to determine the phosphorylated tau interactome.

30 tion led to a high confidence, yeast nuclear interactome.

31 ycle and offers insights into the host-virus interactome.

32 gorithm were applied to both yeast and human interactomes.

33 pecific proteins present in DISC1 endogenous interactomes.

34 ular profile for the splice site and protein interactomes.

35 on network motif clustering in heterogeneous interactomes.

36 when viewed in the context of proteome-wide interactomes.

37 with different constituents forming complex interactomes.

38 cular smooth muscle-specific protein-protein interactome (218 nodes and 632 edges, P < 10(-5) ).

39 Finally, we discuss the concept of the RTK interactome: a putative, extensive network of interactio

40 ive component in the AR-associated chromatin interactome, acting in concert to achieve coordinated re

41 ncer-beating molecules using these 'learned' interactome activity profiles.

42 based methods and random walkers exploit the interactome allowing the prediction of further genes for

43 ontributions of BET protein modules to their interactomes allowing for a better understanding of phar

44 est that deeper knowledge of the CXCR4/ACKR3 interactomes along with their phosphorylation and ubiqui

45 Moreover, Parkin interactomes also involve signaling pathways and transcr

46 esented a differential view of human protein interactome among the cancers.

47 Transcriptome and mRNA-interactome analyses indicated that the impact on VSG si

48 criptome profiling and crosslinking-mediated interactome analyses, we discovered that the expression

49 CD81 interactome analysis also suggests that conformational s

50 Interactome analysis detects no significant binding to o

51 yme-catalyzed proximity labeling for protein interactome analysis in live tissue and expand our under

52 We performed a mass spectrometry-based interactome analysis of 169 tagged, stably-expressed can

53 An interactome analysis revealed that Yip1-interacting fact

54 An interactome analysis to understand cellular processes re

55 s, Metascape combines functional enrichment, interactome analysis, gene annotation, and membership se

56 sis, we characterized the early embryo Me31B interactome and compared it to the known ovary interacto

57 In vivo interactome and density fractionation reveal that Rhes c

58 We also characterize the SMTNL2 proximal interactome and find that SMTNL2 executes its functions

59 Here, we examine the location, protein interactome and function of PhIL1, an IMC-associated pro

60 Thus, comprehensive interactome and functional profiling of BRD proteins rev

61 hensive view of the endogenous human cohesin interactome and identify splicing factors and RBPs as fu

62 phocytes which modulated the local cell-cell interactome and induced a specific transcriptional respo

63 netic methods to define the sorting platform interactome and interactions with the T3SA inner membran

64 The interactome and pathway analyses of DEGs using Ingenuity

65 spectrometry experiments to identify PRMT7's interactome and potential substrates to better character

66 sequence-structure conservation, functional interactome and promoter analysis.

67 ands the current knowledge of the human CTCF interactome and represents an important resource to dire

68 e describe the functional properties of each interactome and show that these GAP/GEF proteins are hig

69 of the Academy of Athens) analyzing the PLN interactome and Stephan Lehnart (University of Gottingen

70 of novel techniques to characterize the GPCR interactome and to identify residues subjected to post-t

71 genes unique to each state, and constructed interactome and transcription factor (TF)-centered upstr

72 ty-based probe of the ferrous iron-dependent interactome and uncovers new targets for the therapeutic

73 onsiderations in intervening at the level of interactomes and gene-regulation.

74 characterization of substrate specificities, interactomes and localization, we reveal at the systems

75 e of the reciprocal influence of CXCR4/ACKR3 interactomes and phosphorylation states.

76 iple postnatal stages, we construct cellular interactomes and regulatory signaling networks.

77 Our findings reveal receptor-specific interactomes and suggest a generalizable model for cue-s

78 When we compared the interactomes and the signaling pathways activated by dis

79 first graphical representation of the immune interactome, and is comprised of 253 immune system compo

80 the E2A-PBX1-enforced cistrome, the E2A-PBX1 interactome, and related mechanisms underlying leukemoge

81 ases in OMIM, using both weighted and binary interactomes, and compared it with state-of-the-art meth

82 Interactome approaches allowed us to identify many prote

83 Approximately 184 genes in the cilia interactome are targeted by 548 currently approved drugs

84 Recent studies of TPC structure and their interactomes are aiding the development of direct pharma

85 Our results show that protein interactomes are larger than previously thought and cont

86 interactions over time and that a resilient interactome arises through gradual change of the network

87 he SLC25A1-SLC25A4 mitochondrial transporter interactome as associated with the 22q11.2 genetic defec

88 nd potentially that of other proteins in its interactome, as causes of human CAKUT, offering new rout

89 3, and HCoV-OC43), allowing us to probe this interactome at a much higher resolution than genome-scal

90 and proteomics profiling identified a FUNDC1 interactome at the mitochondrial inner membrane, compris

91 eractomes to network failures and finds that interactomes become more resilient during evolution, mea

92 ore resilient during evolution, meaning that interactomes become more robust to network failures over

93 ness and host range which considers the full interactome between a specific host species and a virus,

94 The aim of this study was to provide an interactome between miRNAs and their targetome in Chagas

95 onstrate the dynamics of the beta-actin mRNA interactome by characterizing its changes on serum-induc

96 Then, we construct the isoform interactome by predicting that an isoform loses an inter

97 This RTK interactome can produce unique signaling outputs; can am

98 The DISC1 interactomes can be clustered into several subcomplexes

99 al microbiome and its role in the functional interactome cannot be overlooked.

100 RNA interactome capture (RIC) uses in vivo UV crosslinking,

101 n greatly expanded by the development of RNA-interactome capture (RIC).

102 with rRNA and was identified in several RNA-interactome capture experiments.

103 on poly(A)(+) RNA, we combine poly(A)(+) RNA interactome capture with a whole-cell extract normalizat

104 We used RNA interactome capture, a method for the global identificat

105 wever, little is known about how the protein interactome changes across environmental perturbations.

106 Here we focus on two different interactomes, chromatin interaction network and gene reg

107 Expression of SLC25A1-SLC25A4 interactome components was affected in neuronal cells fr

108 The resulting protein interactome comprised 76 unique interactions among 24 pr

109 We defined an interactome consisting of 223 proteins, which showed str

110 More importantly, the NTHi laminin interactome consisting of the well-studied and novel Lbp

111 alysis, we found that the cardiac syndecan-4 interactome consists of 21 novel and 29 previously descr

112 The resulting cilia "interactome" consists of 165 ciliary proteins, 1,011 kno

113 integrative approach to determine the miRNA interactome controlling the response to inflammatory cyt

114 The existence of the RTK interactome could provide an explanation for the irrepro

115 In addition, we found from published interactome data that a mammalian Prp40 homologue PRPF40

116 h experimentally and computationally derived interactome data to build a RIG-I protein interaction ne

117 The interactome data will be important for future studies of

118 ntify RNA-dependent proteins (proteins whose interactome depends on RNA).

119 defining a protein as RNA dependent when its interactome depends on RNA.

120 Histone interactomes derived from different data sources show li

121 ave been modified to quantitatively identify interactome differences between targets under a range of

122 The interactome distance is also predictive for different ty

123 teomics revealed a remarkably invariant PrP* interactome during its trafficking from the endoplasmic

124 have revealed global changes within the Gal9 interactome during lysosomal damage.

125 ughput to make it practical to study protein interactome dynamics.

126 In conclusion, the NTHi interactome exhibited a high plasticity of interactions

127 This study provides another perspective in interactome exploration and biological network reconstru

128 codazole arrest, and present a bacterial RNA-interactome for Escherichia coli.

129 The RNA-RNA interactome for ProQ contains hundreds of pairs.

130 proteomes, characterization of the membrane interactome has lagged, partly due to the necessary use

131 The functional characterization of the GPCR interactome has predominantly focused on intracellular b

132 on network in its entirety: the "neuroimmune interactome." Identification of the nature of the intera

133 Mass spectrometry of the PRMT1 protein interactome identified the CSNK1a1 kinase, which also pr

134 Comparative analyses of the interactomes identified common and unique interaction pa

135 is study provides a global view of the Hsp90 interactome in a fungal pathogen, demonstrates the dynam

136 Furthermore, investigation of the IgSF interactome in a large cohort of cancer patients identif

137 subtilis and extend the members of the GpsB interactome in all three bacterial species.

138 cation in healthy lungs to a T(H)2-dominated interactome in asthmatic lungs.

139 ased proteomics approach to identify the Zta-interactome in cells derived from Burkitt's lymphoma.

140 comprehensive map of the host cell-pathogen interactome in EBV(+) malignancies.See related commentar

141 comprehensive map of the host cell-pathogen interactome in EBV-associated cancers.

142 actome." Identification of the nature of the interactome in health and its plasticity in disease will

143 In addition, the DISC1 interactome in iPSC-derived neural progenitor cells asso

144 Here we mapped the ZIKV-host interactome in neural stem cells (NSCs) and found that D

145 o address this, we characterized the F-actin interactome in spread interphase and round mitotic cells

146 trometry enabled the delineation of the CD22 interactome in the B cell line DT40.

147 s, we report that mDia1 has a stage-specific interactome, including Prohibitin2, MyoD, Akt2, and beta

148 of TMDs and subsequent alteration in the TMD interactome is a molecular basis of sensing mechanical f

149 onal regulator whose comprehensive chromatin interactome is enriched with schizophrenia risk genes.

150 In bacteria, we find that a more resilient interactome is in turn associated with the greater abili

151 on have been extensively studied yet the Akt interactome is less understood.

152 skeletal and exocytic proteins, but the full interactome is not known.

153 ains in ATL paralogues and show that the ATL interactome is profoundly reprogrammed following dengue

154 Deciphering the variations in the protein interactome is required to reach a systems-level underst

155 een identified, the knowledge about the CD22 interactome is still incomplete.

156 The interactome is the deepest reported to date.

157 ource called the Lung Tumor Microenvironment Interactome (LTMI).

158 The NTHi interactome mainly targeted multiple heparin-binding dom

159 re we present a human 'all-by-all' reference interactome map of human binary protein interactions, or

160 Interactome maps connecting disease-risk variants in cel

161 egrative analysis of these promoter-centered interactome maps reveals widespread enhancer-like promot

162 harmacological inhibition of three other RNA interactome members, PPIA, ATP1A1, and the ARP2/3 comple

163 proof of principle to identify heterogeneous interactome modules (HIMs), each of which represents a c

164 rk proximity analysis performed on the human interactome, molecular simulations, and residue-interact

165 ive bioinformatics and human protein-protein interactome network analyses, then confirmed with target

166 These genes were used to devise an interactome network propagation framework integrated wit

167 COSMIC, followed by the construction of PCa Interactome network using the curated genes.

168 ug effects that takes into account the human interactome network, proximity measures between drug tar

169 profiles mapped to the human protein-protein interactome network.

170 number of studies reveal that host-microbial interactome networks are coordinated, impacting human he

171 each other, the basic principles of how such interactome networks respond to environmental unpredicta

172 n require comprehensive understanding of the interactome networks that mediate genotype-phenotype rel

173 ) was used to simulate drug actions on human interactome networks to obtain genome-wide activity prof

174 ical entities such as genomes, proteomes and interactome networks.

175 s provide insight into the CSP landscape and interactome of a specific excitatory synapse and reveal

176 ented by an in-depth analysis of the protein interactome of AATF containing a large set of proteins k

177 , our multilayer analysis of the protein-RNA interactome of AATF reveals this protein to be an import

178 the first time, the extensive human protein interactome of arenavirus nucleoproteins and uncovers a

179 irect and proximal partners constituting the interactome of ataxin-1[85Q] in Neuro-2a cells, pathways

180 a case study, we used EPIC to map the global interactome of Caenorhabditis elegans, defining 612 puta

181 al signaling properties, and phosphorylation/interactome of CXCR4 and ACKR3.

182 ishing, we characterized the thiol-dependent interactome of cytosolic Prx1a and mitochondrial Prx1m f

183 Here, we determine the comprehensive interactome of H2A.Z and identify PWWP2A as a novel H2A.

184 our efforts to unravel the complexity of the interactome of herpes simplex virus type 1 (HSV1), the p

185 n system can efficiently isolate the complex interactome of HSP chaperone family proteins under norma

186 oots by mass spectrometry and established an interactome of IRT1.

187 vage sites of APP: proteomic analysis of the interactome of ISVAID suggests that beta- and alpha-secr

188 Quantitative proteomics reveals an interactome of known readers as well as protein complexe

189 Here we define the interactome of MIWI2 in mouse fetal gonocytes undergoing

190 spective protein targets within the cellular interactome of molecular interactions.

191 However, the interactome of multiple other cell types, particularly T

192 In this study, we determined the broad interactome of NP1 using the proximity-dependent biotin

193 he results provide initial insights into the interactome of Prxs at the level of a eukaryotic whole c

194 des a general strategy for interrogating the interactome of RNA modifications and reveals the biochem

195 RNAs in gene activation by profiling the RNA interactome of SMARCB1-containing SWI/SNF complexes in p

196 By identifying the interactome of SPY, we identified PSEUDO-RESPONSE REGULA

197 Here, we sought to map the cardiac interactome of syndecan-4 to better understand its funct

198 dulate apoptosis; however, the transmembrane interactome of the antiapoptotic protein Mcl-1 remains l

199 d proteomic analyses in order to resolve the interactome of the delta-opioid receptor (DOPr) in its n

200 we experimentally mapped the in vivo RNA-RNA interactome of the full-length SARS-CoV-2 genome and sub

201 sequencing, studies of the three-dimensional interactome of the genome that involve multiple Hi-C dat

202 Several proteins in the protein interactome of the targets of several of these drugs wer

203 TT and combinatorially target factors in the interactome of Xist, the noncoding RNA responsible for X

204 Here we study interactomes of 1,840 species across the tree of life in

205 Integration of the interactomes of 16 IAC-associated baits revealed a netwo

206 DNA interactomes of 80 heterodimers and 22 homodimers reveal

207 Here, we profile the interactomes of BRD2, BRD3, BRD4, and BRDT following tre

208 e, we have investigated the localization and interactomes of endogenously tagged CK1delta and CK1epsi

209 pendent biotin identification to analyze the interactomes of full-length and truncated forms of RAG1

210 ptional regulators and membrane scaffolds in interactomes of importance to human diseases and plant q

211 ive method for studying the localization and interactomes of inhibitor-bound kinases and, potentially

212 interrogating the cellular localization and interactomes of inhibitor-bound kinases.

213 at have been recurrently detected in the RNA interactomes of multiple species.

214 proteomic approach was taken to identify the interactomes of the coreceptors CD2 and CD28.

215 N-terminal residues, we compared the protein interactomes of the full-length and DeltaPR isoforms of

216 SOD1 (B8H10 and AMF7-63), we identified the interactomes of the mitochondrial pools of misfolded SOD

217 Using quantitative proteomics, the local interactomes of these chemically customized chromatin la

218 ized protein-protein interaction network, or interactome, of any eukaryote.

219 identifying the chromatin-dependent protein interactome on the basis of proximity biotinylation, and

220 ation, thrombosis, and fibrosis in the human interactome (P < 0.001).

221 We also found that 19 of the 50 interactome partners bind differently to syndecan-4 in t

222 mbrane Protein Large (MmpL) family and their interactome play important roles in the synthesis and ex

223 ilico computational framework (pathogen host interactome prediction using structure similarity [P-HIP

224 Taken together, the cilia interactome presented here provides novel insights into

225 he cancers, but there was no general protein interactome profile that applied to all cancers.

226 and HepG2, creating a unique resource of RBP interactomes profiled with a standardized methodology in

227 tative trait loci and Epigenomics (DICE) cis-interactome project).

228 ndance induced by viral infection and linked interactome proteins to cellular pathways relevant to SA

229 top hit with gain/loss-of-function genetics, interactome proteomics and tissue imaging, we show that

230 Our map of the IFN interactome provides a global view of the complex cellul

231 tegrating structural domain information with interactomes provides insights into the functional impac

232 This E. coli CEP 'interactome' provides insights into the functional lands

233 significant overlap with the ASD and cancer interactomes, providing network-based evidence that PTEN

234 The concept of key interactome-related nodal points is then evaluated, deal

235 he nature and biological significance of its interactome remain largely unknown.

236 l patterns of these interwoven heterogeneous interactomes remain poorly understood.

237 The IgSF interactome represents an important resource to fuel bio

238 NA translation are highly represented in our interactome result.

239 The cilia interactome revealed interconnections between ciliary pr

240 Initial analysis of this interactome revealed that PP1beta-MYPT1 phosphatase regu

241 The predicted human isoform interactome reveals extensive network remodeling by alte

242 topological properties of the human histone interactome reveals its scale free behavior and high mod

243 lncRNA interactome, RNA immunoprecipitation, and coimmunoprecip

244 nificance using significance analysis of the interactome (SAINT).

245 Overall, our interactome screen illuminates a highly competitive nucl

246 We executed an interactome screen of 564 human cell-surface and secrete

247 s, we have applied an affinity capture-based interactome screen where the experimental design and dat

248 An 'interactome' screen of all Drosophila cell-surface and s

249 Cell-surface interactome screening identifies IgSF8 as a neuronal rec

250 The meta-interactome serves as a model for predicting interaction

251 The two interactomes shared RNA regulation proteins, glycolytic

252 We show that the PTEN interactome shares significant overlap with the ASD and

253 The miRNA-mRNA interactome showed dramatic changes in the Clk(jrk) flie

254 inally, we show that one member of the TRIM2 interactome, signal regulatory protein alpha (SIRPA), a

255 teractions, protein functions, and even full interactome sizes for species with limited to no experim

256 s are located on the thylakoid membrane, and interactome studies indicate that they might associate w

257 ypothesis-driven approaches, and extended by interactome studies of select pathways(3).

258 ecade, several large-scale transcriptome and interactome studies were conducted to understand the com

259 study performed in our lab, (2) data from an interactome study performed in our lab, (3) a publicly a

260 be the iMARGI (in situ mapping of RNA-genome interactome) technique, which is used to discover caRNAs

261 Here, we hypothesize an oral host-microbial interactome that could serve as an ecological chronomete

262 a-catenin mutants displayed distinct protein interactomes that highlight rewiring of signal networks.

263 APEX baits produced almost entirely distinct interactomes that included both known RC proteins and un

264 lications, i.e., prediction methods based on interactomes, that can be used to identify putative drug

265 Within the intrinsically disordered protein interactome, the alpha-helix is commonly used for bindin

266 al experimental efforts to map out the human interactome, the continued data incompleteness limits ou

267 is modulated by a differentiation-dependent interactome. The data have been deposited to the Proteom

268 ion affects protein stability, activity, and interactome, therefore contributing to various diseases

269 We argue that a deeper knowledge of RTK interactome thermodynamics can lead to a better understa

270 insights from the schizophrenia drug-protein interactome to clinical research - an important step, es

271 Our study focuses on the resilience of interactomes to network failures and finds that interact

272 two RNA regulations proteins present in both interactomes, Tral and Cup, revealed that they colocaliz

273 e web services to download genome, proteome, interactome, transcriptome, and 3D molecular structure d

274 nderstand the dynamic changes that the Me31B interactome undergoes from oogenesis to early embryogene

275 between diseases and genes by analyzing the interactomes underlying these diseases.

276 We performed the first analysis of the Hsp90 interactome upon antifungal drug stress and demonstrated

277 nt a systems-level analysis of the organelle interactome using a multispectral image acquisition meth

278 sis of the N-Myc transcriptome, cistrome and interactome using in vivo, in vitro and ex vivo models (

279 Identification of the AIDA-1 interactome using quantitative proteomics reveals protei

280 We studied each of the drugs from the interactome using the BaseSpace Correlation Engine, and

281 oID in capturing membrane-associated protein interactomes using Lotus japonicus symbiotically active

282 This interactome was enriched in DNA damage repair factors, t

283 analysis showed that the phosphorylated tau interactome was enriched in proteins involved in the pro

284 pping (BioID), however, revealed that the GR interactome was strongly modulated by TNF.

285 Although targeting mutant interactomes was proposed as a therapeutic strategy, dru

286 Using the human interactome, we examined the largest connected component

287 analyze the effects of Nop53 on the exosome interactome, we found that the exosome binds pre-ribosom

288 By elucidating the HCV interactome, we identified the 17-beta-hydroxysteroid de

289 isease proteins in the human protein-protein interactome, we show the existence of six distinct class

290 By generating high quality EWS-RNA interactome, we uncovered its specific and prevalent int

291 ociated genes, and from it, the drug-protein interactome which showed the drugs that target any of th

292 is expected that each patient owns a unique 'interactome', which will dictate specific treatment.

293 midbody protein-protein interaction network (interactome), which identifies many previously unknown i

294 gress in the identification of the satellite interactome, which have paved the way to a molecular und

295 Identification of a complex Nol12 interactome, which includes NONO, Dhx9, DNA-PK and Stau1

296 Determining such interactomes will enable the study of how perturbations

297 We integrated the SARS-CoV-2 RNA interactome with changes in proteome abundance induced b

298 Hub proteins are important elements of interactomes within an organism; they bind diverse partn

299 Endogenous DISC1 interactomes within iPSC-derived human neural progenitor

300 induced rapid remodeling of the RNA-protein interactome without corresponding changes in RBP abundan