ライフサイエンスコーパス: intercalated cell

1 oncocytoma seem to originate from the A-type intercalated cell.

2 tted very well to the function of the B-type intercalated cell.

3 of the proton pump to the apical membrane of intercalated cells.

4 decreased size of the apical surface of beta-intercalated cells.

5 position in the ECM underneath adapting beta-intercalated cells.

6 hereas NHE-RF staining was undetectable in A-intercalated cells.

7 almost exclusively to the apical surface of -intercalated cells.

8 t of lumenal H+ secretion by collecting duct intercalated cells.

9 This cell line functionally resembles alpha-intercalated cells.

10 imal tubule brush border and collecting duct intercalated cells.

11 ubated with her serum showed labeling of the intercalated cells.

12 y demonstrated three distinct populations of intercalated cells.

13 e of various cell types, particularly alpha -intercalated cells.

14 hannel by nanomolar Ang II concentrations in intercalated cells.

15 the basolateral conductance of principal and intercalated cells.

16 ecreased pH(i) in pendrin-positive B-type of intercalated cells.

17 ATPase proton pump activity by FOXI1-induced intercalated cells.

18 s urine alkalization by activating the beta -intercalated cells.

19 om reduced function of acid-secretory type A intercalated cells.

20 stic intercalated cells, particularly alpha -intercalated cells.

21 enables to distinguish signals from A- and B-intercalated cells.

22 R607H knockin did not affect type B intercalated cells.

23 an be replaced by the H(+) V-ATPase in renal intercalated cells.

24 ption pathway that we recently discovered in intercalated cells.

25 , suggesting that Aqp2(+) cells give rise to intercalated cells.

26 of two main cell types: principal cells and intercalated cells.

27 enhanced by prorenin receptors (PRRs) on the intercalated cells.

28 ates this differentiation step in the kidney intercalated cells.

29 clonal cell line (clone C) of rabbit kidney intercalated cells.

30 which closely resemble acid-secreting kidney intercalated cells (10,11).

31 ith AE1 on the basolateral membrane of Alpha intercalated cells (A-IC) in outer medullary collecting

32 ly expressed in specialized acid-secreting A-intercalated cells (A-ICs) in the kidney using both imag

33 H(+) secretion in type A intercalated cells (A-ICs) is regulated by apical vesicl

34 alpha-Intercalated cells (A-ICs) within the collecting duct of

35 this issue, Paragas et al. report that alpha-intercalated cells (A-ICs) within the nephron collecting

36 ion is mediated by highly specialized type A intercalated cells (A-ICs), which contain vacuolar H(+)-

37 revealed the unexpected importance of renal intercalated cells, a subtype of cells present in the co

38 However, it is clear now that intercalated cells absorb NaCl and K(+) and hence may pa

39 ted cells and complete elimination of alpha -intercalated cells, accurately recapitulating a newly id

40 Green E. coli BioParticles demonstrates that intercalated cells actively phagocytose bacteria then ac

41 organoids, with differentiated principal and intercalated cells adopting spatial assemblies reflectiv

42 ner stripe of the outer medulla converted to intercalated cells after genetic inactivation of Hes1 an

43 the S(3) segment of the proximal tubule and intercalated cells, after intrarenal administration of a

44 chief regulator of acid base transporters in intercalated cells, along with localization of Cl(-) cha

45 role in the terminal differentiation of the intercalated cell: alpha v beta 1 generates polymerized

46 Alpha intercalated cells (alphaICs) in the kidney collecting d

47 ation in these cells, but unexpectedly, most intercalated cells also had undetectable di-methyl K79,

48 molecule in the terminal differentiation of intercalated cell and perhaps other epithelial cells.

49 ontained primitive cells that expressed both intercalated cell and principal cell proteins, yet the a

50 detected RNase 7 expression in the kidney's intercalated cells and bladder urothelium.

51 ney AE1 and beta1 colocalized in renal alpha-intercalated cells and coimmunoprecipitated (together wi

52 idney disease (PKD) with progressive loss of intercalated cells and complete elimination of alpha -in

53 In both kidney-intercalated cells and epididymal clear cells, cAMP indu

54 The kidneys had reduced intercalated cells and increased transitional cells.

55 ane and recycling vesicles, including kidney intercalated cells and osteoclasts.

56 immunostaining was weak or absent in type B intercalated cells and principal cells of the cortical c

57 ells results in the absence of typical alpha-intercalated cells and the consequent development of com

58 We propose that intercalated cells and their acid/base/electrolyte trans

59 tubule and connecting segment cells, A-type intercalated cells, and non-A, non-B cells express RhCG

60 he apical membrane of collecting duct A-type intercalated cells, and plays a crucial role in hyperten

61 Kidney intercalated cells are involved in acid-base homeostasis

62 Two forms of intercalated cells are present in kidney collecting tubu

63 ically and immunologically distinct types of intercalated cells are present in the mouse kidney.

64 dala central nucleus (lateral division), and intercalated cells, areas known to learn and express ext

65 ecific for principal cells (aquaporin-2) and intercalated cells (band 3 and H(+)-ATPase) show that co

66 e followed intracellular pH in the same beta-intercalated cells before and after acid incubation and

67 base excess, the renal collecting duct beta -intercalated cells ( beta -ICs) become activated to incr

68 by testing whether ammonia stimulates B-type intercalated cell bicarbonate secretion, bicarbonate rea

69 al, mid, and basolateral cytoplasm of type A intercalated cells, but was not observed in the plasma m

70 id-secreting A- and base secreting B-type of intercalated cells cannot be easily separated in functio

71 ion on the basolateral membrane of the alpha-intercalated cell cause autosomal dominant distal renal

72 integrin, and deletion of this gene from the intercalated cell caused a phenotype that was identical

73 d rabbit cell line of collecting duct A-type intercalated cell characteristics (Clone C).

74 Whether this receptor directly regulates the intercalated cell chloride/bicarbonate exchanger pendrin

75 viously been considered part of the amygdala intercalated cell clusters or ventral endopiriform corte

76 Overall, our results suggest that intercalated cells constitute a promising target for pha

77 al cells contain BK-alpha/beta1 channels and intercalated cells contain BK-alpha/beta4 channels.

78 the anion exchanger of a clonal cell line of intercalated cells derived from the kidney can be retarg

79 It resembled a third type of intercalated cell described previously in the rat.

80 Intercalated cells do not participate in cyst expansion

81 nversion of beta-intercalated cells to alpha-intercalated cells during acid incubation depends upon E

82 Taken together, intercalated cells exhibit a transcriptional response co

83 beta-Intercalated cells express basolateral secretin receptor

84 All types of intercalated cells expressed a4.

85 the differentiation of some alpha- and beta-intercalated cells from Aqp2-expressing progenitor cells

86 and receptor-positive and receptor-negative intercalated cells from the same knockout mice.

87 lic alkalosis caused the opposite changes in intercalated cell function, but did not substantially ch

88 Type B intercalated cells had a fairly smooth apical surface, a

89 of vacuolar H(+)-ATPase from collecting duct intercalated cells has been reported.

90 lly and functionally distinct populations of intercalated cells have been described in the collecting

91 Additionally, intercalated cells have increased vacuolar ATPase expres

92 CD) by transcellular transport across type B intercalated cells (IC) via an H(+)-ATPase-and pendrin-d

93 of K recycling across the apical membrane in intercalated cells (IC).

94 1 H + -ATPase subunit is mostly expressed in intercalated cells (IC).

95 The renal collecting duct consists of intercalated cells (ICs) and principal cells (PCs).

96 The collecting duct is composed of intercalated cells (ICs) and principal cells (PCs).

97 Renal intercalated cells (ICs) express the proton pumping vacu

98 e relevance of ClC-K2 in the collecting duct intercalated cells (ICs) for renal function and Cl(-) ho

99 Intercalated cells (ICs) in the mammalian kidney regulat

100 of the B1 proton pump subunit (ATP6V1B1) in intercalated cells (ICs) leads to type I distal renal tu

101 Ca2+-activated BK channels in renal intercalated cells (ICs) mediate luminal flow-induced K+

102 reperfusion injury (IRI) model, we show that intercalated cells (ICs) rapidly adopted a proinflammato

103 , most likely occurring in a alpha- and beta-intercalated cells (ICs), respectively.

104 hich mediate Na, K, and water transport, and intercalated cells (ICs), which are specialized for acid

105 a proportional increase in the percentage of intercalated cells (ICs).

106 ant cell type, with more diffuse staining in intercalated cells (ICs).

107 Type A intercalated cells identified by positive Band 3 stainin

108 Intercalated cells identified by positive staining for H

109 ed cell subtypes, including hybrid principal-intercalated cells identified from single cell transcrip

110 ization of AE in cultured cells and in alpha-intercalated cells identified in sections of rat kidney

111 ) renal cell carcinoma (RCC) arises from the intercalated cell in the distal nephron.

112 uncovered, which resembles the cortical beta-intercalated cell in ultrastructure, but does not expres

113 differentiation of mature principal cells to intercalated cells in adult kidneys.

114 tracellular vesicles of acid-secreting alpha-intercalated cells in renal collecting duct.

115 yed to discriminate between A- and B-type of intercalated cells in split-opened collecting duct prepa

116 the S(3) segment of the proximal tubule and intercalated cells in the collecting duct, the latter id

117 kidney cells, except acid-base transporting intercalated cells in the collecting duct.

118 The results indicate that intercalated cells in the collecting ducts of both corte

119 Essentially all of the intercalated cells in the cortex of the mutant mice are

120 changer expressed in type B and non-A, non-B intercalated cells in the distal nephron, where it facil

121 xpressed at the basolateral surface of alpha-intercalated cells in the distal nephron.

122 olocalize in the basolateral domain of alpha-intercalated cells in the distal nephron.

123 tinct acid-secreting epithelial cells: The A-intercalated cells in the kidney outer medullary collect

124 et al. find that mice lacking Foxi1 have no intercalated cells in the kidney.

125 =5 cell types, including principal cells and intercalated cells in the late distal convoluted tubules

126 ogical characteristics of different types of intercalated cells in the mouse.

127 /HCO3(-) exchange activity in acid-secreting intercalated cells in the OMCD was significantly decreas

128 eview summarizes the current knowledge on CD intercalated cells in urinary tract bacterial clearance.

129 also be involved in the polarity reversal of intercalated cells in vivo.

130 alkalization in different subpopulations of intercalated cells in WT but not ClC-K2(-/-) mice.

131 includes the preservation of H(+)-ATPase in intercalated cells, in patients with presumed voltage de

132 A similar remodeling of beta-intercalated cells, in which the polarity of H(+) pumps

133 gested that the conversion of beta- to alpha-intercalated cells is a manifestation of terminal differ

134 finding that Pkd2 loss triggers the loss of intercalated cells is a suitable topic for further mecha

135 r, a cluster of cells expressing markers for intercalated cells is enriched for genes reported in hum

136 hat Ang II-dependent regulation of ClC-K2 in intercalated cells is instrumental for stimulation of Cl

137 is blocked, the conversion of beta to alpha intercalated cells is prevented and the animals develop

138 hanger in the basolateral membrane of type A intercalated cells is thought to be an essential compone

139 Within the amygdala, GABAergic intercalated cell (ITC) clusters receive one of the dens

140 of evolutionarily conserved neurons form the intercalated cell (ITC) clusters, mainly located around

141 Among GABAergic neurons, the so-called intercalated cells (ITCcs) are critically involved in th

142 The intercalated cells (ITCs) gate amygdala output and thus

143 he neighboring main island (Im) of GABAergic intercalated cells (ITCs) is strongly inhibited by endog

144 Intercalated cells (ITCs) of the amygdala are clusters o

145 The intercalated cells (ITCs) of the amygdala have been show

146 Tshz1 is expressed during development of the intercalated cells (ITCs) within the mouse amygdala.

147 ic population of amygdalar interneurons, the intercalated cells (ITCs), is known to play a fundamenta

148 flow within the amygdala is regulated by the intercalated cells (ITCs), which are densely packed clus

149 M) protein hensin is able to convert a renal intercalated cell line from a flat, squamous shape into

150 as present in the apical membrane of a renal intercalated cell line when these cells were seeded at l

151 Using a beta intercalated cell line, the cause of this phenotypic cha

152 in phenotype was studied in an immortalized intercalated cell line.

153 ly targeted to the basolateral domain in the intercalated cell line.

154 a 230-kD protein in rabbit kidney and in the intercalated cell line.

155 l cells were negative for principal cell and intercalated cell markers examined.

156 inhibitory inputs onto neurons of the dorsal intercalated cell mass (ITC) in the amygdala.

157 leus of the amygdala and medial paracapsular intercalated cell mass, relative to C57BL/6J.

158 patches in the lateral nucleus of amygdala, intercalated cell masses (ICM), and the lateral subdivis

159 irect effect on collecting duct principal or intercalated cells may underlie the reduced urinary PGE2

160 ncipal cells transporting Na(+) and K(+) and intercalated cells mediating Cl(-) reabsorption.

161 the basomedial amygdala (BMA) to the medial intercalated cells (mICCs) in adult mice.

162 Intercalated cell mineralocorticoid receptor ablation bl

163 With high circulating aldosterone, intercalated cell mineralocorticoid receptor ablation re

164 With high circulating aldosterone, intercalated cell mineralocorticoid receptor gene ablati

165 Ablation of the intercalated cell mineralocorticoid receptor in CCDs fro

166 Aldosterone activates the intercalated cell mineralocorticoid receptor, which is e

167 A complete loss of alpha -intercalated cells occurred by P12.

168 ring the response to metabolic acidosis, the intercalated cell of the collecting tubule converts from

169 The intercalated cell of the cortical collecting tubule exis

170 on transporters of the acid-secreting Type A intercalated cell of the renal collecting duct.

171 at pendrin is an apical anion transporter in intercalated cells of CCDs and has an essential role in

172 cells isolated from the proximal tubule and intercalated cells of collecting ducts, we observed coex

173 ing inhibition of glutamate release onto the intercalated cells of the amygdala as an assay for enkep

174 responsible for degrading enkephalins in the intercalated cells of the amygdala.

175 ous opioid concentrations at synapses in the intercalated cells of the amygdala.

176 rin-2, indicating that pendrin is present in intercalated cells of the CCD.

177 ased V-ATPase expression and activity in the intercalated cells of the collecting duct impaired acid-

178 by defective HCO(3)(-) secretion in the beta-intercalated cells of the collecting duct that requires

179 d at the basolateral border of principal and intercalated cells of the collecting duct where it inhib

180 AE1 is mainly active basolaterally in alpha-intercalated cells of the collecting duct, where it is f

181 ven Cl(-)/2HCO3(-) exchanger (NDCBE) in beta-intercalated cells of the collecting duct.

182 The intercalated cells of the collecting tubules of mammalia

183 XGR1 expressed in the type B and non-A-non-B intercalated cells of the connecting tubule (CNT) and th

184 In mouse kidney, the B1-subunit localizes to intercalated cells of the cortical and medullary collect

185 o functional, plasma membrane H(+)ATPases in intercalated cells of the cortical collecting duct and i

186 The renal cystadenomas develop from intercalated cells of the cortical collecting duct and u

187 H recovery rates of individual Atp6v1b1(-/-) intercalated cells of the cortical collecting duct are m

188 density on the apical (luminal) surface of -intercalated cells of the cortical collecting duct of th

189 bule (S1/S2 segment), the loop of Henle, the intercalated cells of the distal convoluted tubule, the

190 pressing the chloride transporter pendrin in intercalated cells of the distal nephron (Tg(B1-hPDS) mi

191 uted tubule, the connecting segment, and all intercalated cells of the entire collecting duct in huma

192 H(+),K(+)-ATPase-mediated H(+) secretion in intercalated cells of the inner cortical collecting duct

193 sed in the basolateral membrane of the beta -intercalated cells of the kidney cortical collecting duc

194 is expressed in erythrocytes and the A-type intercalated cells of the kidney distal collecting duct.

195 in the erythrocyte and in the acid-secreting intercalated cells of the kidney.

196 t subtypes that resemble the alpha- and beta-intercalated cells of the kidney.

197 Here, we show that intercalated cells of the mouse kidney are an exception

198 orter immunoreactivity is localized to alpha-intercalated cells of the outer medullary collecting duc

199 cells and a chloride/base exchanger in beta-intercalated cells of the renal cortical collecting duct

200 ese mutations affect the physiology of the A-intercalated cells of the renal cortical collecting duct

201 In the medullary intercalated cells of the sham-operated kidneys, relativ

202 In the intercalated cells of this segment, it colocalized with

203 proliferation, and/or maintenance of cystic intercalated cells, particularly alpha -intercalated cel

204 iezo1 in functionally distinct principal and intercalated cells (PCs and ICs) of the collecting duct

205 Principal and intercalated cells perform different physiological tasks

206 HCO(3)(-) exchange, indicating a reversal of intercalated cell polarity.

207 ype H(+)-ATPase subunits in pendrin-positive intercalated cells (PP-ICs) and ENaC subunits in princip

208 -A, non-B cells express RhCG and that B-type intercalated cells, principal cells, and inner medullary

209 1 ensured repression of Foxi1 to prevent the intercalated cell program from turning on in mature Aqp2

210 phase, which explains the reduced principal/intercalated cell ratio and may identify the molecular p

211 e PKD with progressive elimination of alpha -intercalated cells, recapitulating a newly identified ce

212 data suggest that BK-alpha/beta4 channels in intercalated cells reduce cell size, increasing luminal

213 The size of intercalated cells reduced and luminal volume increased

214 Intercalated cells represent an epithelial cell with cha

215 s suggest that conversion of polarity of the intercalated cells represents a process of terminal diff

216 Enhancement of inputs to intercalated cells required prefrontal activity during e

217 llecting ducts of the kidney are composed of intercalated cells (responsible for acid/base transport)

218 Functional failure of -intercalated cells results in a group of disorders, the

219 Here, we show that deletion of hensin from intercalated cells results in the absence of typical alp

220 diated by two canonical cell types: the beta-intercalated cell secretes HCO(3) by an apical Cl:HCO(3)

221 and distal professional proton transporting (intercalated) cells sense and respond to changes in pH,

222 ed by immunofluorescent microscopy in WT and intercalated cell-specific ClC-K2(-/-) mice to demonstra

223 nd subcellular distribution in wild-type and intercalated cell-specific mineralocorticoid receptor kn

224 Here we report six human intercalated cell subtypes, including hybrid principal-i

225 uropathogenic Escherichia coli in two of the intercalated cell subtypes.

226 ion of NHE-RF and H(+)ATPase in B- but not A-intercalated cells suggests a role in generating, mainta

227 y 20% fewer principal cells and 13%-16% more intercalated cells than control mice.

228 y three-fold greater when positioned next to intercalated cells than next to principal cells.

229 some patients may have autoantibodies to the intercalated cells that are not directed to subunits of

230 cted exclusively within the subpopulation of intercalated cells that express the H(+)-ATPase but not

231 zes to the basolateral membrane of the alpha intercalated cell, the acid secreting cell of the outer

232 rom the BLA to Ce, perhaps through GABAergic intercalated cells, thereby gating the expression of con

233 Hence, the adaptive conversion of beta-intercalated cells to alpha-intercalated cells during ac

234 showed that the conversion of beta to alpha intercalated cell under the influence of acidification o

235 ion can lead to a reduced ratio of principal/intercalated cells using two-dimensional and three-dimen

236 agues describe a new mechanism by which beta-intercalated cells, via release of ATP and prostaglandin

237 Deletion of Foxi1, which is vital to intercalated cells viability and H(+)-ATPase expression,

238 apted mice, but expression of Na-K-ATPase in intercalated cells was >10-fold lower.

239 Basolateral NaCl exit from beta-intercalated cells was independent of the Na(+)/K(+)-ATP

240 The effects of ammonia on single CCD intercalated cells was studied by use of measurements of

241 In rat brain slices containing the intercalated cells, we found that inhibition of glutamat

242 The a - and B -intercalated cells were apparently derived from embryoni

243 Cystic alpha -intercalated cells were found in the other PKD models.

244 These Aqp2(+) cell-derived intercalated cells were present in both developing and m

245 /HCO3(-) exchange in erythrocytes and kidney intercalated cells where it functions to maintain normal

246 nnel is expressed on the basolateral side of intercalated cells, where it governs Cl(-) -dependent H(

247 LRRC8E is specific for intercalated cells, whereas LRRC8A, LRRC8B, and LRRC8D a

248 and decreased proton transport in B-type of intercalated cells, whereas metabolic alkalosis caused t

249 e apical or the basolateral region of B-type intercalated cells, whereas NHE-RF staining was undetect

250 Acid secretion is mediated by the alpha-intercalated cell, which has an apical V-ATPase and a ba

251 er that localizes to type B and non-A, non-B intercalated cells, which are expressed within the aldos

252 s in TSC is predominantly composed of type A intercalated cells, which do not exhibit noticeable expr

253 lian collecting duct comprises principal and intercalated cells, which maintain sodium/water and acid

254 This B1 isoform is amplified in renal intercalated cells, which play a role in distal urinary

255 A third type of intercalated cell with apical and cytoplasmic H+-ATPase,

256 Type A intercalated cells with apical H+ -ATPase and basolatera

257 Type B intercalated cells with basolateral and cytoplasmic H+-A

258 remnant kidneys, the percentage of medullary intercalated cells with predominant plasma membrane H(+)

259 cortical collecting ducts, the percentage of intercalated cells with well-polarized apical and well-p

260 nregulation and a reduced ratio of principal/intercalated cells, yet lithium induces principal cell p