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1 istinct structural components of the cardiac intercalated disc.
2  assembly of functional gap junctions in the intercalated disc.
3 58stop with other junctional proteins at the intercalated disc.
4 ed disc and complete loss of vinculin at the intercalated disc.
5 d connection between the myocytes called the intercalated disc.
6 riate PKP2 localization at the cardiomyocyte intercalated disc.
7 ts revealed target candidates of Mst4 at the intercalated disc.
8 connection with membrane proteins within the intercalated disc.
9 tion of Pyk2 activity maintained Cx43 at the intercalated disc.
10 and yet its exclusion from the region of the intercalated disc.
11 alcium/calmodulin-dependent kinase II to the intercalated disc.
12 and yet its exclusion from the region of the intercalated disc.
13 within the cardiac transitional junction and intercalated disc.
14 N-cadherin, is an essential component of the intercalated disc.
15 al continuum between cells also populate the intercalated disc.
16 end-end contact between myocytes, within the intercalated disc.
17 at electrically couple cardiomyocytes at the intercalated disc.
18 hat it interacts with other molecules of the intercalated disc.
19 gates and the absence of desmin filaments at intercalated discs.
20 tissues with predominant localization at the intercalated discs.
21 , and disruption of Kv1.5 trafficking to the intercalated discs.
22 nexin43, loss of gap junctions, and abnormal intercalated discs.
23 brils, while DARP staining also increased at intercalated discs.
24 iciently trafficked to adherens junctions at intercalated discs.
25 ient (Arg975Trp), revealing grossly abnormal intercalated discs.
26 in EDMD are caused by absence of emerin from intercalated discs.
27 line, and CPbeta2 organizes the actin at the intercalated discs.
28  domains of actin that attach to Z bands and intercalated discs.
29 is beta 1 isoform was found in costamers and intercalated discs.
30 ing delivery of Cx43 hemichannels to cardiac intercalated discs.
31  the ventricle but a marked incidence at the intercalated discs.
32 es, internalization and/or reduced levels at intercalated discs.
33 cardial Cx43 gap junction plaque size at the intercalated discs.
34  for full-length Cx43 forward trafficking to intercalated discs.
35 emains partially stable and localized at the intercalated discs.
36 contribute to losses in Cx43 localization at intercalated discs.
37 nt to reduce levels of Cx43 gap junctions at intercalated discs.
38 3 and the microtubule-capping protein EB1 at intercalated discs.
39 e for NMII-B in maintaining the integrity of intercalated discs.
40 (alphaMHC) hearts develop marked widening of intercalated discs.
41 ed with reduced cardiomyocyte contractility, intercalated disc abnormalities, and fibrosis, demonstra
42 smosome-like structures and regional loss of intercalated disc adhesion.
43  the heart protects Cx43 localization to the intercalated discs against acute ischemic injury.
44      beta1 is at the Z-line; beta2 is at the intercalated disc and cell periphery in general.
45 e preceded by ultrastructural defects in the intercalated disc and complete loss of vinculin at the i
46 a mechanism for direct communication between intercalated disc and contractile apparatus.
47 58stop gap junctions to the periphery of the intercalated disc and further revealed an increase in th
48 udies revealed that Mst4 is localized to the intercalated disc and interacts with several intercalate
49 lization of ZO-1 and Cx43 at the ventricular intercalated disc and modestly decreased left ventricula
50 Ankyrin-G and Na(v)1.5 are both localized at intercalated disc and T-tubule membranes in cardiomyocyt
51  cardiac muscle, dysferlin is located at the intercalated disc and transverse tubule membranes.
52      Cardiac LRP6 is spatially restricted to intercalated discs and binds to gap junction protein con
53 attribute arrhythmias to the loss of Cx43 at intercalated discs and compromised gap junctional coupli
54 ly expressed in the heart and is enriched at intercalated discs and costameres.
55 ubule interaction with adherens junctions at intercalated discs and reduced connexon delivery and gap
56  myofibrillar collapse with abnormalities of intercalated discs and sarcolemmal membranes.
57 ta resulted in the failure of forming mature intercalated discs and the mislocalization of mXinalpha
58 rlie the uncoupling of desmin filaments from intercalated discs and their structural disorganization.
59 forms NBCe1 and NBCn1 to lateral sarcolemma, intercalated discs and transverse tubules (t-tubules), w
60 ocalized AKAP100 to the nucleus, sarcolemma, intercalated disc, and at the level of the Z-line.
61 echanotransmission within the sarcomere, the intercalated disc, and at the sarcolemma.
62 f sarcomeric organization, disruption of the intercalated disc, and cell-autonomous loss of cardiomyo
63  and localizes to the Z-disk, cell membrane, intercalated disc, and nuclear membrane of adult rat hea
64 n the adherens junction of the cardiomyocyte intercalated disc, and perturbations in its expression a
65 ficking of Cx43, reduced localization in the intercalated disc, and suggested decreased membrane Cx43
66 usion protein was incorporated into Z-bands, intercalated discs, and attachment plaques, as well as i
67                         FXR1 associates with intercalated discs, and integral gap junction proteins C
68  remodeling of the ICD by determining the 3D intercalated disc architecture using serial block face s
69  of beta-catenin and ZO-1 at the ventricular intercalated disc are dependent on CAR.
70 , particularly at the ends of the cell where intercalated discs are commonly located, and where NHE1
71  and animal models provide insights into the intercalated disc as a functional unit and into the basi
72 modeling of myofibrils, focal adhesions, and intercalated discs as cooperative ensembles.
73 ls and tissues during myofibrillogenesis and intercalated disc assembly.
74 at AnkG is a key functional component of the intercalated disc at the intersection of 3 complexes oft
75 Cx43, and destroyed the gap junction and the intercalated disc between the cardiomyocytes, implicatin
76 ression of the truncated DSC2 protein at the intercalated discs but only minor changes in immunoreact
77 erin did recognize both nuclear membrane and intercalated discs but, after affinity purification agai
78 rdiomyocytes are electrically coupled at the intercalated discs by gap junctions.
79 t mice revealed structural remodeling of the intercalated disc characteristic of human patients with
80 ression and localization of gap junction and intercalated disc components.
81 s microtubules, titin, desmin, collagen, and intercalated disc components.
82                                              Intercalated discs composed of desmosomes, adherens junc
83 l studies showed that there was a gap at the intercalated disc consisting of cell membranes and a reg
84                                          The intercalated disc contains different junctional complexe
85 cal changes that occur within the sarcomere, intercalated disc, costamere, and extracellular matrix.
86 d in membrane anchorage complexes, including intercalated discs, costameres, and myotendinous junctio
87 adherin desmoglein 2 (Dsg2) localizes to the intercalated disc coupling adjacent cardiomyocytes.
88 ght that the decrease in Cx43 protein at the intercalated discs culminated in diminished electrical c
89 d hemichannels must be correctly targeted to intercalated discs, Cx43 being the major connexin in the
90 acement fibrosis, interstitial fibrosis, and intercalated disc dissociation.
91 sis, increased fetal gene expression, higher intercalated disc fold amplitude, decreased calsequestri
92  analysis of these hearts revealed disrupted intercalated disc formation and a failure in the attachm
93 PKP2cKO), a desmosomal protein important for intercalated disc formation, commonly mutated in ARVC an
94 known roles in myocyte epithelialization and intercalated disc formation, N-cadherin appears to play
95                                          The intercalated disc (ICD) between two cardiomyocytes was d
96                                          The intercalated disc (ICD) is a unique membrane structure t
97                                          The intercalated disc (ICD) is a unique structure to the hea
98 osomes and adherens junctions located at the intercalated disc (ICD) of cardiomyocytes, where it func
99                                          The intercalated disc (ICD) orchestrates electrochemical and
100 phosphorylation cluster in the cardiomyocyte intercalated disc (ICD) protein, alphaT-catenin (CTNNA3)
101 nker proteins resulted in dissolution of the intercalated disc (ICD) structure.
102                                              Intercalated discs (ICD), specific cell-to-cell contacts
103 extracellular potentials occurring in narrow intercalated disc (ID) clefts.
104                           Mislocalization of intercalated disc (ID) components, connexin-43 (Cx43) ga
105                                          The intercalated disc (ID) is a "hot spot" for heart disease
106                                          The intercalated disc (ID) is a highly specialized structure
107 ific set of 170 genes encoding cardiomyocyte intercalated disc (ID) proteins are more enriched for as
108 ytoskeletal network that localized mainly at intercalated discs (IDs) and conferred cardioprotection
109 We further localized NOS1AP to cardiomyocyte intercalated discs (IDs) and demonstrate that overexpres
110 ed interruption of DSP-desmin interaction at intercalated discs (IDs) and marked ultra-structural cha
111 ntials within narrow intercellular clefts in intercalated discs (IDs) which influence the Na(+) curre
112 g genes, as well as genes that stabilize the intercalated disc in postnatal atrium.
113 chronic uninhibited PKCalpha activity at the intercalated disc in the absence of functional MLP leads
114 ylation (P=0.043) and maintained Cx43 at the intercalated disc in the distal ventricle 6 weeks post-M
115 tionship of the structural components of the intercalated disc in the working myocardium, thus establ
116  plakoglobin, desmoplakin, and connexin43 at intercalated discs in cardiac myocytes.
117                                              Intercalated discs in cardiomyocytes from four of six hu
118  adherens junction proteins and localizes to intercalated discs in cardiomyocytes.
119     Here, we show that iASPP is expressed at intercalated discs in human and mouse postmitotic cardio
120          Nine out of 10 mAbs located DMPK to intercalated discs in human heart, an affected tissue in
121  different emerin epitopes did not recognize intercalated discs in the heart, though they recognized
122               Kcne5 protein localized to the intercalated discs in ventricular myocytes, where K(V)2.
123 n of force transmission at the thin filament-intercalated disc interface is the likely mechanism by w
124 ONALE: Delivery of Cx43 (connexin 43) to the intercalated disc is a continuous and rapid process crit
125 the chronic PKCalpha signalling chain at the intercalated disc is broken and they remain healthy.
126 t kindlin-2 is an essential component of the intercalated disc, is necessary for cytoskeletal organiz
127 cellular junctions, including the myocardial intercalated disc; it is known to mediate cell-cell reco
128 ents induces excessive mechanical loading of intercalated discs, leading to assembly of stabilizing f
129                  Molecular remodeling of the intercalated discs leads to pathogenic activation of the
130 ss decreased Cx (connexin) 40 expression and intercalated disc localization.
131 ot only an essential role of mXinbeta in the intercalated disc maturation but also mechanisms of mXin
132 roles of mXinbeta in cardiac development and intercalated disc maturation were investigated.
133                                       As the intercalated disc matures, we postulated that focal adhe
134  data for the molecular pathway required for intercalated disc Nav1.5 targeting/regulation in heart.
135                     Although enriched in the intercalated disc, NaV1.5 is present in different membra
136  of electrical and mechanical junctions into intercalated discs occurs during postnatal development.
137 d-stage DCM, PKCalpha is concentrated at the intercalated disc of cardiomyocytes, where it is sequest
138 teins mXinalpha and mXinbeta localize to the intercalated disc of mouse heart and are implicated in c
139 lized with N-cadherin and connexin-43 in the intercalated discs of adult mouse hearts.
140 onula occludens-1 (ZO-1) localization to the intercalated discs of CAR-cKO mouse hearts at 8 weeks be
141 d of pressure overload (PO) hypertrophy near intercalated discs of cardiomyocytes, where integrins ar
142 essed in cardiomyocytes and localized in the intercalated discs of mouse and human hearts.
143 e is abundant subtype 2 of SK protein in the intercalated discs of myocytes.
144 of SK protein showed increased expression in intercalated discs of myocytes.
145 y genetic defects in proteins of the cardiac intercalated disc, particularly, desmosomes.
146 2 binding was dependent on expression of the intercalated disc plaque protein plakoglobin (Pg) and di
147  to demonstrate distinct hubs at the cardiac intercalated disc, populated by clusters of the adhesion
148  it is also a cardiac binding partner of the intercalated disc protein Myozap.
149 lecular mechanism by which cardiac-expressed intercalated disc protein Xinbeta modulates Hippo-YAP si
150  associated with mutations in genes encoding intercalated disc proteins and ultimately results in sud
151 eads to disrupted trafficking of sarcolemmal intercalated disc proteins to junctional membranes and a
152          Localization and levels of selected intercalated disc proteins, including signaling molecule
153  the expression or localization of other key intercalated disc proteins.
154 intercalated disc and interacts with several intercalated disc proteins.
155 th antibodies specific to 406W-desmin and to intercalated disc proteins.
156 the sarcolemma, colocalized with NHE1 at the intercalated disc regions, increased NHE1 phosphorylatio
157 y of myocardium showed irregular, convoluted intercalated disc regions, loss of contractile elements
158 cant co-localization of PP2A(c) and NHE1, in intercalated disc regions.
159 se mice showed both myofibril disruption and intercalated disc remodeling, as predicted.Therefore, CP
160 ut mice, we provide microscopic evidence for intercalated disc remodeling.
161 the cell-cell interface, suggesting that the intercalated disc required mechanical reinforcement.
162 coupling to Ca2+ release microdomains at the intercalated disc, resulting in enhanced Ca2+ dynamics.
163 aV1.5 expression at the lateral membrane and intercalated disc revealed that the lateral membrane poo
164                                          The intercalated disc serves as an organizing center for var
165 at ankyrin-G links Nav channels with broader intercalated disc signaling/structural nodes, as ankyrin
166 l adherens junctions with dissolution of the intercalated disc structure, expression of the junctiona
167 of N-cadherin resulted in disassembly of the intercalated disc structure, including adherens junction
168 oform metavinculin are protein components of intercalated discs, structures that anchor thin filament
169 e of specialized extracellular clefts within intercalated discs such as the perinexus.
170 these complexes and plays essential roles in intercalated discs that are necessary for muscle cell fu
171 t the cell-cell interface and forming mature intercalated discs that transmitted the systolic load.
172 ary lies between the myofibrillar I-band and intercalated disc thin filaments, identifiable by the pr
173 ms precursor hemichannels that accrue at the intercalated disc to assemble as gap junctions.
174 elling, which involves its displacement from intercalated discs to the lateral sides of cardiomyocyte
175  broad range of tissues and localizes to the intercalated discs, to the perinuclear region, and overl
176              Altered protein constituents of intercalated discs were associated with activation of th
177 s would not be expected if immunostaining at intercalated discs were due to a product of the emerin g
178                    Structural changes within intercalated discs were revealed by the abnormal organiz
179 e to the heart muscle plasma membrane at the intercalated disc where the myofibrils lead into the adh
180  heart, it is localized predominantly at the intercalated disc, where its function is not known.
181 adherin and beta-catenin localization at the intercalated discs, where both NM II-B and II-C are norm
182 ning in myocyte sarcolemmal membranes and at intercalated discs, whereas caveolin-1 staining was prom
183 lly protects gap junctional communication at intercalated discs, while NBC locally protects t-tubular
184                  Alp also colocalizes at the intercalated disc with alpha-actinin and gamma-catenin,
185 were born with a functional heart presenting intercalated discs with incorporated desmosomal proteins
186 PN(Y20C) Tg mice developed HCM and disrupted intercalated discs, with disturbed expression of desmin,
187 ssing beta1 showed altered morphology of the intercalated disc, without the lethality or myofibril di

 
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