ライフサイエンスコーパス: interchain

1 .2 K and a coupling between the chains of zJ(interchain) = -1.5 K for BDTTh(2)-NN by a Heisenberg cha

2 The interchain (13)C-(19)F dipolar coupling measured in a ro

3 We present a method to probe intra- and interchain activities within dimeric nonribosomal peptid

4 2 domain makes a minimal contribution to the interchain affinity in factor VIII.

5 tibody, indicating that equilibration of the interchain and intrachain hinge disulfide pairing was no

6 zation stems from the appropriate balance of interchain and intrachain metal ion coordination by Gla

7 ists of two polypeptide chains linked by two interchain and one intrachain disulfide bond.

8 or interfaces formed between polymer chains (interchain) and within a polymer chain (intrachain).

9 part of the same trend, due to the different interchain arrangement associated with the phase change.

10 s very similar to one of the natural dimeric interchain associations evident in the structure of solu

11 The emissions are caused by intrachain and interchain aurophilic interactions between the linear Au

12 in hydrogen bond, which confirms that direct interchain backbone hydrogen bonding is a major force fo

13 articipation in disulfide linkage, which was interchain based on the direct correlation between preva

14 Interchain beta-sheet (ICBS) interactions occur widely i

15 guide the development of agents that control interchain beta-sheet interactions and that the database

16 624 cm(-1) was characteristic of the nascent interchain beta-sheets, consistent with protein aggregat

17 domains contribute approximately 90% of the interchain binding energy in factor VIII and that A3 dom

18 contain mutations which affect one probable interchain bond were nonviable and could not be propagat

19 bonds and is connected to the virion by one interchain bond.

20 ositol anchor, which dimerizes through three interchain bridges.

21 Our results suggest that interchain Ca(2+) coordination in con-T[K7gamma] is incu

22 teractions include numerous salt bridges and interchain cation-pi interactions, but not intramolecula

23 le further extending the IDT core to promote interchain charge transfer, is a logical strategy toward

24 tained in these polymers owing to additional interchain charge transfer.

25 rly two orders of magnitude greater than the interchain charge transport along the pi-pi stacking dir

26 s is the first example to clarify intra- and interchain charge transport based on an individual singl

27 ggered triple helical species facilitated by interchain charged pairs, and is inspired by similar sti

28 elopeptide sites, and between the individual interchain combinations.

29 her strengthens or weakens one of the native interchain contacts (prevalent in the transition state e

30 reasing the counteranion (CA) size decreases interchain contacts and aggregation and leads to a subst

31 yp-Gly)5 shows evidence for the existence of interchain contacts between alpha-carbon hydrogens from

32 eutral pH, we observed weak N- to C-terminal interchain contacts driven by electrostatic interactions

33 Increased interchain contacts give rise to a lowering of the photo

34 Mixed-charge clusters are prominent at interchain contacts where they stabilize quaternary prot

35 g transition state characterized by very few interchain contacts.

36 and wrap around one another, with extensive interchain contacts.

37 d upon aggregation, indicating their role as interchain contacts.

38 n be either increased or decreased by tuning interchain cooperativeness via the introduction of a sin

39 ted structures to show that the reduction in interchain coupling is not due simply to increased packi

40 o-dimensional lamellar structures, increased interchain coupling strongly influences the traditional

41 few chains, prohibiting long-range effective interchain coupling.

42 little effect of electrostatic disorder and interchain coupling.

43 lky iodo-substituent packs within a nonpolar interchain crevice.

44 MD simulations support sustained interchain cross-domain interactions in STAT5B(N642H), c

45 The potential for interchain cross-link formation by the analogous crotona

46 esented for the formation of a carbinolamine interchain cross-link in 5'-CpG-3' sequences, arising fr

47 used to explain the 5'-d(CpG) preference for interchain cross-linking by acrolein.

48 ble, polymeric nanogels using a simple intra/interchain cross-linking reaction.

49 tail domain residues were used for extensive interchain cross-linking.

50 ine on the tail domain were used for limited interchain cross-linking.

51 Six interchain cross-links distinguished between alternative

52 that S,S-DEB produced the highest number of interchain cross-links in 5'-GGC-3'/3'-CCG-5' sequences.

53 part, why the (6S,8R,11S) stereoisomer forms interchain cross-links in the 5'-CpG-3' sequence whereas

54 Interchain cross-links represent one of the most serious

55 oxynucleotide duplexes containing 2a to form interchain cross-links was evaluated by HPLC, CZE, MALDI

56 F-Cz) via precisely preventing excitons from interchain cross-transfer/coupling and contamination fro

57 haracterization of the positional isomers of interchain cysteine linked ADCs is very challenging, mai

58 he characterization of positional isomers of interchain cysteine linked ADCs.

59 Interchain cysteine linked antibody-drug conjugates (ADC

60 Here, we present a comparative study of interchain cysteine linked IgG1 ADCs and the correspondi

61 ges were due to the presence of drugs on the interchain cysteine residues or the absence of intact in

62 t of the intact mass of an ADC conjugated at interchain cysteine residues.

63 lt from the attachment of drug conjugates to interchain cysteine residues.

64 trulline-monomethyl Auristatin E (vcMMAE) at interchain cysteine residues.

65 resence of vcMMAE or mcMMAF on the alkylated interchain cysteine residues.

66 Cs, mAbs, reduced mAbs (containing 8 reduced interchain cysteine thiols), and partially reduced mAbs

67 The size variants of an interchain cysteine-linked ADC were characterized to und

68 toxic payloads are selectively linked to the interchain cysteines and generate heterogeneous mixtures

69 of antibody-drug conjugates (ADCs) using the interchain cysteines of the antibody inherently gives a

70 d previously in the literature for analyzing interchain cysteinyl-linked ADCs are either not amenable

71 the reference method for quality control of interchain cysteinyl-linked ADCs.

72 s in such a low polarity medium, may reflect interchain delocalization of the hole.

73 is33 or His26 and have been used to estimate interchain diffusion rates of the protein.

74 constant should not be used as a measure of interchain diffusion, and the results emphasize the impo

75 hains that eliminate the restrictions on the interchain displacements, leading to the opening of the

76 The variation is attributed to increased interchain distance corresponding to decreased interchai

77 e of two separate peaks corresponding to the interchain distances within the crystalline lattices of

78 c-TeNT(RY) at C439S and C467S eliminated the interchain disulfide bond and inhibited betalac transloc

79 al modifications including a membrane-distal interchain disulfide bond and negatively charged O-linke

80 ted by electron transfer and addition to the interchain disulfide bond between Cys(215) of the light

81 l fragment ions due to the protection of the interchain disulfide bond between light and heavy chain,

82 carboxy termini and stabilized by forming an interchain disulfide bond between the Cys39 residues of

83 ed an improved scFab format that retains the interchain disulfide bond by increasing the linker lengt

84 T and TeNT are dichain proteins linked by an interchain disulfide bond comprised of an N-terminal cat

85 either engineered surface-exposed or reduced interchain disulfide bond cysteine residues.

86 ch the VH-VL heterodimer is stabilized by an interchain disulfide bond engineered between structurall

87 in and prepro-von Willebrand factor promotes interchain disulfide bond formation among polypeptides i

88 Interchain disulfide bond formation indicates that both

89 ro-von Willebrand factor is also involved in interchain disulfide bond formation, which is consistent

90 Under nonreducing conditions where the interchain disulfide bond is intact, the enzymatically i

91 We conclude that: 1) the Cys6 interchain disulfide bond of SP-A is required for aggreg

92 e buffer containing zinc and DTT reduced the interchain disulfide bond releasing and activating the c

93 However, this format required removal of the interchain disulfide bond to achieve modest display leve

94 of C8 alpha and C8 gamma in which the single interchain disulfide bond was eliminated.

95 Under an acidic condition, the interchain disulfide bond was selectively cleaved with t

96 e light chain cysteine residue that forms an interchain disulfide bond with the cysteine residue in t

97 betalac-TeNT(RY) retained the interchain disulfide bond, showed ganglioside-dependent

98 ic specificity of the TCR do not require its interchain disulfide bond, transmembrane segments, or gl

99 each chain was common to peptides having an interchain disulfide bond, while for peptides having int

100 in to promote the formation of an additional interchain disulfide bond.

101 ting the presence of at least one additional interchain disulfide bond.

102 minal of both sequences, which could mediate interchain disulfide bonding, and 11 of the 14 aromatic

103 ere are cysteines in conserved positions for interchain disulfide bonding, and there is a conserved t

104 suggesting that the N termini are linked by interchain disulfide bonds and are presented on the cell

105 The MEDI3726 protein scaffold lacks interchain disulfide bonds and has an average drug to an

106 in the ADCs was due to the absence of intact interchain disulfide bonds and not the presence of vcMMA

107 Isoform A contains two covalent interchain disulfide bonds at heavy chain positions 239

108 The two endogenous interchain disulfide bonds between Cys16 and Cys37 in RI

109 nd 242, while isoform B fails to develop any interchain disulfide bonds but has 239-242 intrachain di

110 ies, which can be achieved by first reducing interchain disulfide bonds followed by conjugation of th

111 y performing online EC-assisted reduction of interchain disulfide bonds in an intact mAb, the release

112 44, and Cys13246) may be involved in forming interchain disulfide bonds in mucin dimers.

113 ked oligosaccharide, the collagen helix, and interchain disulfide bonds in SP-D assembly and secretio

114 sociation of these subunits is stabilized by interchain disulfide bonds involving two conserved amino

115 Head-to-tail interchain disulfide bonds link subunits within the homo

116 Furthermore, it was found that reduction of interchain disulfide bonds occurs in the ESI source depe

117 ted trisulfide bonds are associated with the interchain disulfide bonds of both A isoform and A/B iso

118 We found that Trx reduces the interchain disulfide bonds of the mAbs, after which they

119 at the alpha chains are covalently linked by interchain disulfide bonds only between the two cysteine

120 nfirmed that without alkylation, Trx-reduced interchain disulfide bonds reoxidize, and ADCC activity

121 /D is a compact docking module, with unusual interchain disulfide bonds that help maintain the AKAP i

122 c configuration is characterized by strained interchain disulfide bonds that stabilize the P-loop in

123 in also influenced the susceptibility of the interchain disulfide bonds to attack by reducing agents

124 h IdeS and/or PNGase F, and (3) reduction of interchain disulfide bonds to generate ~25 kDa ADC subfr

125 ysteine at position 23, which forms aberrant interchain disulfide bonds, causes disruption of the nor

126 with cysteine residues that were involved in interchain disulfide bonds.

127 of the cysteines required for intrachain and interchain disulfide bonds.

128 equence or loss (by mutation) of the insulin interchain disulfide bonds.

129 o antiparallel B chains held together by two interchain disulfide bonds.

130 te the presence of at least two NH2-terminal interchain disulfide bonds.

131 ules are physically linked to each other via interchain disulfide bonds.

132 rved cysteine residues, which participate in interchain disulfide bonds.

133 -presumably a coiled coil-held together with interchain disulfide bonds.

134 ysteine thiols generated by the reduction of interchain disulfide bonds.

135 eta can form malfolded structures containing interchain disulfide bonds; malfolding is correlated wit

136 Both cysteine 524 and cysteine 682 form interchain disulfide bonds; their conversion to serine r

137 ise serine substitution of insulin's exposed interchain disulfide bridge (Cys(A7)-Cys(B7)) are charac

138 ese subclasses are characterized by specific interchain disulfide bridge connections.

139 Additionally, interchain disulfide bridge experiments showed that the

140 y through an Ile/Leu hydrophobic core and an interchain disulfide bridge.

141 involves low pH, proteolysis, and an intact interchain disulfide bridge.

142 Secreted proenzyme formed non-native, interchain disulfide bridges and displayed only residual

143 ix formation in the collagen-like domain and interchain disulfide bridges at the NH2 terminus.

144 from Cys --> Ser replacements was found for interchain disulfide bridges involving the four cysteine

145 Nature uses interchain disulfide bridges to stabilize collagen trime

146 of an adjacent collagen triple helix to form interchain disulfide bridges.

147 re structure where they form both intra- and interchain disulfide bridges.

148 The Cys-13 should be available for interchain disulfide bridging and consequent aggregation

149 of chicken gizzard tropomyosin with a single interchain disulfide cross-link.

150 A class of ADCs that utilize the reduced interchain disulfide cysteine residues for drug attachme

151 numbers of drugs linked to different former interchain disulfide cysteine residues on the antibodies

152 se data support the requirement of an intact interchain disulfide for LC translocation and imply that

153 Disruption of interchain disulfide formation at Cys(-)(1) by substitut

154 at only Cys6 in this region is available for interchain disulfide formation.

155 spholipids into type II cells; 3) N-terminal interchain disulfide linkage can functionally replace th

156 two closely related isoforms, that requires interchain disulfide linkage for several functions inclu

157 These processes also occur when interchain disulfide linkage is inhibited, indicating th

158 l for function, the importance of the second interchain disulfide linkage within the N-terminal Isole

159 does not require the collagen-like region or interchain disulfide linkage; 2) the N-terminal portion

160 to some recombinant proteins with intra- or interchain disulfide linkages are presented.

161 e-stranded coiled coils, and surface-exposed interchain disulfide linkages mediate the formation of t

162 zation of both "left-arm" and "right-arm" HL interchain disulfide peptides and observed that native H

163 Dynamic interchain disulfide rearrangement, with slow kinetics,

164 A dimeric species, stabilized by an interchain disulfide, appears to be involved in the asse

165 The recombinant NC1 formed interchain disulfide-bonded dimers and trimers and was N

166 In contrast to the numerous examples of interchain disulfide-linked aggregates, factor VIII is t

167 isomerization was resolved by engineering an interchain disulfide.

168 The interchain disulfides between the light and heavy chains

169 light and heavy chains were weaker than the interchain disulfides between the two heavy chains.

170 n cysteine residues or the absence of intact interchain disulfides or both.

171 ins IgG and IgE, but has differently located interchain disulphide bonds and external rather than int

172 The small interchain electron effective mass is comparable to the

173 In contrast to rr-P3HT, interchain energy migration in poly(3-(2'-methoxy-5'-oct

174 hexylthiophene) (rr-P3HT) enables long-range interchain energy migration, while disordered packing in

175 The different intrachain and interchain energy transfer time scales explain the behav

176 at polymer/copolymer concentrations near the interchain entanglement threshold.

177 -average molar mass (M(w)) and the extent of interchain entanglements (c/c).

178 emonstrates that the N17 module also reduces interchain entanglements between polyQ domains.

179 Therefore, the combination of a reduction of interchain entanglements through homopolymeric polyQ and

180 ely matched for molar mass and the extent of interchain entanglements.

181 1) K, where J(1) and J(2) are the intra- and interchain exchange couplings, respectively, which consi

182 ordering at T(N) = 7 K due to intrachain and interchain exchange interactions.

183 Interchain exchange is estimated to be 33- to 150-fold w

184 The interchain exchange is estimated to be zJ/k congruent wi

185 terchain distance corresponding to decreased interchain exchange, when more F4BImNN is added into the

186 we present a unique case to demonstrate that interchain excitation energy migration via intermolecula

187 arser phase segregation and formation of the interchain excited states that are energetically unfavor

188 s the slow phase is attributed to intra- and interchain exciton diffusion to the HMIDC.

189 ingle-chain aggregates, implying rather weak interchain excitonic coupling and energy transfer.

190 omain that lead to preferential formation of interchain excitons delocalizing over more than one poly

191 Such energetics of the interchain excitons in low-bandgap copolymers calls for

192 We propose that such interchain H-bonding may destabilize metal binding in th

193 Stable intrachain and interchain H-bonds are identified as a function of tempe

194 mers of a single cellulose polymer chain and interchain H-bonds between adjacent chains.

195 f-association to form a coiled-coil or other interchain helical structure.

196 thermal broadening becomes comparable to the interchain hopping energy remains an unresolved issue, o

197 ypothesize that the methyl group shields the interchain hydrogen bond between the glycine and the Xaa

198 luded in MP2, is a significant factor in the interchain hydrogen bond energies.

199 isostere peptide that retained the backbone interchain hydrogen bond, which confirms that direct int

200 in the X position suggests the importance of interchain hydrogen bonding directly or through water to

201 small but cooperative decrease on the total interchain hydrogen bonding energy.

202 Our significant finding is that interchain hydrogen bonding is greatly affected by varia

203 eneral feature of triple-helical structures: interchain hydrogen bonds are always longer and weaker t

204 Interchain hydrogen bonds contribute to the interaction

205 ond instance of water mediated N--H ... O==C interchain hydrogen bonds for the amide group of the res

206 ting that the conformational change involves interchain hydrogen bonds in the amyloid fibrils that ar

207 rences in solvent shielding of the essential interchain hydrogen bonds may result in differences in s

208 with a buried surface area of 1738 A2 and 33 interchain hydrogen bonds resulting from C-terminal stra

209 The presence of interchain hydrogen bonds results in the expansion of th

210 line, and that residue side chains also form interchain hydrogen bonds with frequencies that are depe

211 nge rate for glycine NH residues involved in interchain hydrogen bonds.

212 residue, a high content of imino acids, and interchain hydrogen bonds.

213 s, and this ratio compensates for the weaker interchain hydrogen bonds.

214 ributions of the beta-ladders in the overall interchain interaction and compute first- and second-ord

215 imple model that also yields a value for the interchain interaction energy.

216 The interchain interaction is unstable with respect to the f

217 observed in the ternary complex, mediated by interchain interaction of the C terminus at the tetramer

218 is varied to tune the molecular packing and interchain interaction of the polymers in order to eluci

219 these types of residues are those that make interchain interaction only through the protein main cha

220 In addition, three distinct DNA interchain interaction regimes were found to exist, due

221 tematic study of the roles of crystallinity, interchain interaction, and exciton delocalization on ul

222 nticipated key role of GPI-AP in FcepsilonRI interchain interactions and early FcepsilonRI signaling

223 orphology-dependent variations of intra- and interchain interactions and order in poly-3-hexylthiophe

224 onequivalence of these positions in terms of interchain interactions and solvent exposure.

225 ation greatly influences both intrachain and interchain interactions and ultimately the degree of pha

226 tions, while at low pH, the C- to C-terminal interchain interactions are significantly stronger and d

227 ystem) between protein fragments propitiates interchain interactions at early stages of the folding p

228 species originate from excimers produced by interchain interactions being mediated by the particular

229 The six interchain interactions between Glu-239 in one catalytic

230 es in collagen are characterized in terms of interchain interactions between non-imino acid X and Y r

231 Interchain interactions between pi-systems have a strong

232 These transient interchain interactions coupled with a non-A beta amyloi

233 we systematically investigated non-covalent interchain interactions for CH3 domains in the other hum

234 e study the impact that the resulting strong interchain interactions have on the photophysical proper

235 gregation providing insight into the role of interchain interactions in these subsecond switching ele

236 he hybrid enzyme only three of the usual six interchain interactions involving Glu-239 are sufficient

237 This suggests that interchain interactions of pi-systems over their entire

238 netic ground state, stemming from weak pi-pi interchain interactions of strength J( perpendicular)/k(

239 The impact of interchain interactions on the charge carrier effective

240 The effects of interchain interactions on the component and state separ

241 to an increase in the strength and number of interchain interactions that are induced by organic comp

242 ed structural plasticity engendering greater interchain interactions that can accelerate pathological

243 Characterization of these first interchain interactions will provide fundamental insight

244 Observation of a network of interchain interactions, as established by NOE spectrosc

245 We report further VCD evidence of chiral interchain interactions, consistent with some amounts of

246 e N-terminal region may arise from transient interchain interactions, suggesting that the N-terminal

247 This is difficult to achieve, as interchain interactions, which are needed to ensure effi

248 The BBT moiety also strengthens interchain interactions, which provides higher thermal s

249 bamoylase is governed by specific intra- and interchain interactions.

250 he packing geometry of the molecules and the interchain interactions.

251 h 85 long-range NOE cross peaks arising from interchain interactions.

252 mer, which enables extensive interdomain and interchain interactions.

253 485, and 508 and glutamines 465 and 489 for interchain involucrin cross-links.

254 r Lys but not for Arg and can be assigned to interchain ion pairs, as shown by molecular modeling.

255 placing one arginine residue, which forms an interchain ionic interaction with a glutamic acid residu

256 ecific distribution of hydrophobic residues, interchain ionic interactions can be crucial in modulati

257 vironment and to evaluate the intrachain and interchain Li-ion hopping mechanisms.

258 Trisulfides were detected only in interchain linkages and were predominantly in the light-

259 weight polymers with triazole- and urea-type interchain links, respectively.

260 st a few chains, can dramatically impede the interchain mechanism.

261 rphology on energy migration in CP, tailored interchain morphologies were achieved using solvent vapo

262 ormational variability results in disordered interchain morphology even between a few chains, prohibi

263 To probe the effect of interchain morphology on energy migration in CP, tailore

264 he actual displacements were decomposed into interchain motions and intrachain deformations.

265 he transmembrane helices mainly results from interchain motions that already take place in the closed

266 re presumably much weaker in energy than the interchain N-H...O=C hydrogen bonds responsible for the

267 tal number of native contacts, the number of interchain native contacts, and the total conformational

268 The strength of these interchain NH(Val)...O=C hydrogen bonds varies in the or

269 lting transition, and observation of several interchain NOEs.

270 es that are consistent with the formation of interchain, nonnative disulfide bridges and the establis

271 mination program CYANA to build a network of interchain nuclear Overhauser effect constraints that ca

272 nks loricrin and SPRs together to form small interchain oligomers, which are then permanently affixed

273 ulated phenalenyls along [0 0 1], and (2) an interchain overlap involving a pair of carbon atoms (C4)

274 8 exhibits stronger pai-pai interactions and interchain packing compared to classic donor polymers, a

275 -chain conformation and hence highly ordered interchain packing in aggregates.

276 Surprisingly, the ordered and close interchain packing in F-P3EHT does not lead to strong ex

277 We report that highly ordered interchain packing in regioregular poly(3-hexylthiophene

278 hysical properties of polymers by modulating interchain pai-pai networks by light.

279 ymes that incorporate l-amino acids into the interchain peptide bridge of Gram-positive cell wall pep

280 X enzyme that initiates the synthesis of the interchain peptide of the peptidoglycan in a subset of b

281 rge family of genes previously implicated in interchain peptide synthesis but with unknown specific f

282 First, P3HT-SH nanofibers were formed due to interchain pi-pi stacking.

283 For a mixing time of 1200 ms, 5 A interchain proximities appear.

284 e elucidated the pre-steady-state intra- and interchain rates and the corresponding flux of the acyla

285 it is likely that they contain intra- and/or interchain repulsions by acidic residues.

286 Because interchain residue-residue contacts can be used as dista

287 l residual network method (DRCon) to predict interchain residue-residue contacts in homodimers from r

288 tein interaction interfaces make exclusively interchain residue-type-independent contacts.

289 Site-directed mutagenesis identified an interchain salt bridge (Lys(48)-Glu(47')) in the RHH dom

290 ine, a change that results in the loss of an interchain salt bridge between alphaArg76 and betaAsp57

291 employed to ascertain the role of intra- and interchain salt-bridges in the folding and stability of

292 nduced charge separation, in contrast to the interchain separation achieved in conventional donor-acc

293 hain conductors with different values of the interchain single-electron transfer integral tb, which q

294 one-dimensional linear chains, with a large interchain spacing (5.83 angstrom) enabling reversible M

295 keratin filament terminals and increases the interchain spacing of the filaments.

296 t concomitantly increase chain stiffness and interchain spacing, thereby resulting in ultramicroporos

297 xcited state structures, and dynamics of the interchain species by combined ultrafast spectroscopy an

298 ion pathways originating from intrachain and interchain species.

299 e similar to those of wild-type insulin, the interchain tether constrains the extent of conformationa

300 We find that despite the interchain transport becoming non-metallic, the charge c