ライフサイエンスコーパス: interfere with

1 defines an innovative RNA-based strategy to interfere with a pivotal function of the tumor-related l

2 decline in 1 or more cognitive domains that interferes with a person's independence in daily activit

3 By interfering with a developmental program that normally l

4 For other ligands, selectivity is caused by interfering with a water molecule that binds more strong

5 Finally, interfering with abscission impairs naive pluripotency e

6 ed how ab8 neutralized the virus by directly interfering with ACE2 binding.

7 um by transcription of upstream lncRNAs that interferes with activation of the flanking mRNA promoter

8 iated neurologic adverse events and suggests interfering with adhesion as a mitigation approach.

9 Interfering with amebic CPs decreased amebic trogocytosi

10 heRS, this toxicity of m-Tyr may result from interfering with amino acid metabolism, destabalizing a

11 eta-burst TMS to LOC (and a control site) to interfere with an extended window (approximately 30-50 m

12 sion of major histocompatibility complex and interfering with antigen presentation in murine models a

13 e was therefore to assess whether pollen may interfere with antiviral immunity.

14 malaria parasites (Plasmodium falciparum) by interfering with apicoplast function.

15 or-binding area suggested that glycosylation interferes with APOE's attraction to receptors, lipid-bi

16 Mutational disruption of ARF1 spacing interfered with ARF1-dependent trafficking but not with

17 rotective pathways and chemokine-selectively interferes with atherosclerosis.

18 velope kinesin recruitment in other systems, interferes with BicD2 binding.

19 controlled by "negative constraints", which interfere with binding.

20 based substances of undocumented purity that interfere with bioassays and have a low likelihood of be

21 Quorum sensing inhibitors (QSIs) interfering with biofilm formation can thus complement a

22 These guanine-derived oxidative DNA lesions interfere with both replication and transcription.

23 Further analyses revealed that DJ34 interferes with c-Myc synthesis at the level of transcri

24 In addition, GS-6207 interferes with capsid binding to the cellular HIV-1 cof

25 ce between capsid protein monomers, where it interferes with capsid-protein-mediated interactions bet

26 BP did not interfere with CAR assembly or the rate of CAR constrict

27 ed MIF inhibitors, whereas msR4M-L1 does not interfere with cardioprotective MIF/CD74 signaling.

28 Our results support a model in which R-DPRs interfere with cargo loading on karyopherins.

29 vely use CXCR4 have V3 loop protrusions that interfere with CCR5 receptor interactions.

30 omoter of the WHI5 inhibitor, or vice versa, interfered with cell size homeostasis, yielding a broade

31 nistration of 5-bromo-2'-deoxyuridine (BrdU) interferes with cell proliferation and leads to the acti

32 ouble up as ubiquitin hydrolases (DUB), thus interfering with cellular processes critical for virus r

33 Inhibitors of CME that interfere with clathrin function have been described, bu

34 spacer peptide 1 (SP1) subunits of Gag, and interfere with cleavage between CA and SP1 catalyzed by

35 , named CLK8, that specifically bound to and interfered with CLOCK activity.

36 sm could provide a targeting opportunity for interfering with collective cancer cell invasion.

37 y target S. suis in systemic disease without interfering with commensal strains, opening up new avenu

38 n (replacement/alteration) approaches, which interfere with competence to transmit pathogens.

39 Lyme disease spirochetes interfere with complement by producing a small arsenal o

40 ry representations can capture attention and interfere with concurrent visual search.

41 and enhance consolidation of that memory and interfere with consolidation of the others (particularly

42 ion coefficient analysis confirmed bilirubin interfered with creatinine, with worsening agreement in

43 To limit interfering with critical background genetics, we used C

44 BMP signaling might allow to therapeutically interfere with cutaneous psoriatic manifestations.

45 whether SAM syndrome-causing DSG1 mutations interfere with Cx expression and GJ function.

46 y, we identify that the deubiquitinase USP36 interferes with degradation of PrimPol to regulate the r

47 vide a mechanism by which TDP-43 dysfunction interferes with dendritic branching, and may define path

48 ict the probability that a new chemical will interfere with different combinations of cellular and te

49 s the first study to show that pembrolizumab interferes with differentiation of human FOXP3(+) iTregs

50 We find that absence of ETO2 in mice interferes with down-regulation of PU.1 and GATA2 in the

51 tDCS over the sensorimotor cortex interferes with dream movement during REM sleep, which i

52 Interfering with DupA-ubiquitin binding switches its act

53 Many interspecifically territorial species interfere with each other reproductively, and in some ca

54 panied by increased TKI tolerance, which can interfere with ectopic SOX2 expression.

55 ncomplete Okazaki fragment maturation, which interferes with efficient PCNA unloading by ATAD5 and su

56 hain deletion increases thermal instability, interfering with efficient posttranslational modificatio

57 Knockdown of Rab5A, Rab5C, or USP15 interferes with EL targeting of mitochondria and functio

58 Manmade chemicals can interfere with endocrine processes and have permeated ma

59 Among these are novel products that interfere with epithelial cell alarmins, dendritic cell

60 further insights on how Plasmodium parasites interfere with erythropoiesis and contribute to anemia i

61 Cmp7, Lem2 formed aggregates that appear to interfere with ESCRT-independent NE sealing.

62 s eluted into the mass spectrometer (MS) and interfering with evaluation.

63 Consequently, the possibilities of interfering with exhaustion are numerous.

64 aggravated rather than alleviated injury by interfering with expression of BA transporters, hepatocy

65 Consistently, interfering with extrinsic forces by reducing the contra

66 ry mechanisms may potentially be co-opted or interfered with for therapeutic benefits.

67 ally, we identify NEMF mutations expected to interfere with function in patients from seven families

68 How this interferes with fundamental behavioral processes remains

69 In addition, this construct interfered with Galpha(s)Q227L's ability to guide PRG's

70 es an approach to screen for antibodies that interfere with gB's fusogenic activity.

71 ne kinase phosphorylates E2 at tyrosine 131, interfering with genome replication.

72 fficacious in the joint but not the gut, and interfering with gut trafficking by targeting molecules

73 Platelet-specific abrogation of Arp2/3 interferes with haptotactic repositioning of platelets t

74 RNAi reduction of Se-sEH interfered with hemocyte-spreading behavior, nodule form

75 hemicals (EDCs) are exogenous chemicals that interfere with hormone action, thereby increasing the ri

76 on, rather than H3K36me3 or DNA methylation, interfere with host gene transcription and pre-mRNA proc

77 , the mechanisms by which the stress pathway interferes with host response to pathogens remain unclea

78 uito entrance into human-occupied spaces and interfering with host-seeking and blood-feeding.

79 Anti-BAFF treatment interferes with humoral responses at multiple levels in

80 n alters the conformation of the amide bond, interferes with hydrogen bond formation, and changes oth

81 hose AD patients with allergic sensitization interferes with IgE-mediated inflammatory processes in A

82 Lubrication of the device did not interfere with IgG, IgA, or hemoglobin ELISA.

83 rough suppression of NF-kappaB activation by interfering with IKK activity.

84 Mutant HTT (mHTT) disrupts transcription, interferes with immune and mitochondrial function, and i

85 cteria likely exist, which either promote or interfere with immunotherapy efficacy.

86 clearance, but only if the drug is unable to interfere with infection of the first cells.

87 igger escape from dormancy of microtumors by interfering with inflammation resolution and triggering

88 ose infection with the drug tenofovir, which interferes with initial infection, and atazanavir, which

89 viously shown that Arid1b haploinsufficiency interferes with interneuron development and leads to soc

90 to curb inflammation would therefore likely interfere with intestinal homeostasis.

91 lins, molecules of the schweinfurthin family interfere with intracellular lipid distribution and meta

92 that infect vertebrates encode proteins that interfere with IRF3 activation.

93 e mutants of GRAF1/2, WDR44, and MICAL1 also interferes with it, facilitating future studies of Rab8/

94 Our work showed that PD-1 blockade interferes with iTreg differentiation and has no potenti

95 uivalent mutations in yeast Rqc2 selectively interfere with its ability to modify aberrant translatio

96 ification of MIF binding molecules that also interfere with its biological activity.

97 ked glycosyl residues from these IgG did not interfere with its entry into the podocytes but eliminat

98 upt stability of the whole protein, and thus interfere with its functional interactions.

99 o identify compounds likely to bind PRLR and interfere with its signaling.

100 trinsically disordered regions (IDR) of EloA interfere with its targeting and localization to the nuc

101 wed that losing one of the leucoplast motifs interfered with its function in root leucoplasts but had

102 discusses the different strategies aimed at interfering with its biologic activity as well as their

103 enesis by physically interacting with Ascl1, interfering with its DNA binding and limiting neurogenes

104 anscriptional and ventralizing activities by interfering with its lysine methylation.

105 und PRMT6 to methylate CRAF at arginine 100, interfering with its RAS/RAF binding potential, and ther

106 r drug-induced DNA-protein crosslinks (DPCs) interfere with key DNA transactions if not repaired in a

107 elative contraindication to FLACS, as it may interfere with laser beam delivery, thus causing unpredi

108 We then demonstrate that interfering with left but not right posterior parietal c

109 ving EVD, which in 85.8% was rated as highly interfering with life.

110 r disruption of the circadian clock severely interferes with light-evoked attraction/avoidance behavi

111 Cancer growth interferes with local ionic environments, membrane poten

112 whether exposure to fine particulate matter interferes with lung recovery and remodeling in a murine

113 In this work, we show that IFN signaling interferes with lung repair during influenza recovery in

114 at subnanomolar concentrations that did not interfere with lysosomal acidification or degradation an

115 also introduce mechanical perturbations that interfere with measurements of the behavior.

116 totic entry reverses apical contractility by interfering with medioapical RhoA signaling.

117 transcript increased 12-fold, apparently to interfere with melanization.

118 Interfering with membrane interaction by mutating select

119 dorsal hippocampus and that SETD6 knockdown interferes with memory consolidation, alters gene expres

120 Interfering with memory reconsolidation or inducing memo

121 dly affects progenitor numbers, but does not interfere with MET.

122 previously shown to impair COMT activity by interfering with methyl donor-acceptor compaction within

123 vation of glycogen synthase kinase-3 (GSK-3) interferes with microtubule assembly.

124 AF-16 modulates mitochondrial homeostasis by interfering with mitochondrial dynamics and mitophagy.

125 Mutations at both interfaces interfered with mitogen-activated protein kinase (MAPK)

126 However, biologic agents interfering with monoclonal antibodies is not widely con

127 nteraction with the A-site codon to possibly interfere with mRNA movement through the channel and/or

128 nse to Mtb infection and possible avenues to interfere with Mtb infection, including vitamin B5 suppl

129 extensions of the CP, which would sterically interfere with Nb binding.

130 inhibition of de novo lipid biosynthesis by interfering with nematode ACC is a new nematicidal mode

131 troporation into the developing rat brain to interfere with Nesprin-2 function.

132 Together, these data support that interfering with netrin-1 could be a viable therapeutic

133 neurodevelopmental delay/autism, possibly by interfering with neuronal migration early in cortical de

134 ion of P may represent a general strategy to interfere with NNS RNA virus replication.

135 nal dominance of MDS HSPCs and indicate that interfering with noncanonical NF-kappaB signaling could

136 to endocrine disrupting chemicals (EDCs) may interfere with normal brain development and predispose f

137 learn how the retention of PCNA on DNA might interfere with normal DNA metabolism, we studied the res

138 Many drugs, like pentamidine, interfere with normal K(v)11.1 forward trafficking and t

139 Liver fibrosis interferes with normal liver function and facilitates he

140 alter the dynamics of a viral population by interfering with normal virus replication and/or by stim

141 se inhibitors (GSIs), have been developed to interfere with Notch receptor activation at proximal poi

142 we describe a pharmacological strategy that interferes with Notch signaling by disrupting the Notch

143 the interaction between CLOCK and BMAL1 and interferes with nuclear translocation of CLOCK both in v

144 C) is one of the most painful cancers, which interferes with orofacial function including talking and

145 thus highlight the therapeutic potential of interfering with osteoclast-intrinsic metabolic pathways

146 low- and high-resolution MS, which does not interfere with other types of small compound analyses do

147 Drugs that interfere with oxPAPC-driven metabolic changes reduce at

148 log of transmembrane domain 2 (TM2) of CXCR4 interfered with PAR1:CXCR4 heteromerization.

149 Antibodies that bind PIMMS43 interfere with parasite immune evasion when ingested wit

150 of not belonging, emotional exhaustion, and interfered with patient communication.

151 ally persist beyond the acute disease stage, interfering with patients' recovery and quality of life.

152 novel pharmacologic combination therapy that interferes with PAX3-FOXO1 biology at different levels.

153 the KTKEGV repeat domain of alpha-Syn, which interfere with phospholipid binding, are ineffective in

154 Phytoene overproduction initially interferes with photosynthesis, acting as a metabolic th

155 get biotic pathways, particularly those that interfere with plant innate immunity.

156 e that siR109944 has a conserved function in interfering with plant immunity, growth, and development

157 a suggest that Pol II transcription robustly interferes with Pol III function at specific tRNA genes.

158 Nerinetide, an eicosapeptide that interferes with post-synaptic density protein 95, is a n

159 Neither oncohistone interferes with PRC2 binding.

160 FBP1 inhibits glycolysis but also directly interferes with PRC2 function, thus FBP1 and PRC2 are pa

161 thalamocortical model, training a new memory interfered with previously learned old memories leading

162 o normal controls, PI3K/mTOR hyperactivation interfered with primary cilia assembly (scenario also ob

163 beta2AR-ROS redox axis, which if disturbed, interferes with proper receptor function.

164 L RNA in the signal recognition particle and interfere with protein trafficking to the cell membrane

165 These sodiated ions interfere with protonated ions of the species of the sam

166 ces a slow conformational rearrangement that interferes with purinergic stimulation of the exchanger,

167 The presence of fluorescence can interfere with Raman detection and is virtually impossib

168 the Set3C complex, recruiting RNA pol II and interfering with Rap1 binding to activate genes in other

169 Inhibiting GLI1 interferes with rDNA DSB repair and impacts RNA polymera

170 ct it as a continuous use of mechanisms that interfere with re-weighing the temptation.

171 reveal two distinct epitopes, but both VHHs interfere with receptor binding.

172 , including double strand breaks (DSBs) that interfere with replication.

173 n through RNA polymerase backtracking, which interferes with replication forks, leading to DNA double

174 eneration, where the disease phenotype often interferes with retinal development, in Tvrm4 mice, the

175 as the former prevent cell-cycle entry, thus interfering with S-phase- or mitosis-targeting agents.

176 hough structurally similar to ES24, does not interfere with SecYEG-dependent protein trafficking.

177 istones selectively promote PRC2 activity by interfering with SETD2-mediated H3K36 methylation.

178 In mice, CYP17A1 deficiency interferes with sex differentiation.

179 Wound-induced JA responses directly interfered with short-term adaptation to ET by blocking

180 Shift work interferes with sleep and causes fatigue with adverse ef

181 d that LY6E inhibits CoV entry into cells by interfering with spike protein-mediated membrane fusion.

182 vation of p38 MAPK in high glucose condition interferes with Src-extracellular signal-regulated kinas

183 The hydrogel was expected not to interfere with standard tissue characterization methods,

184 e, our study establishes innovative tools to interfere with STAT3 signaling by different molecular me

185 tic antibody mimetics, termed monobodies, to interfere with STAT3 signaling.

186 t a vulnerability factor to medications that interfere with sterol biosynthesis.

187 To specifically interfere with stromal signals, we generated Wnt-indepen

188 early activation of natural killer cells and interferes with subsequent adaptive immune cell recruitm

189 s cluster in the composite E3 domain, likely interfering with substrate ubiquitination.

190 e becoming a common cancer entity, which may interfere with survival in relatively benign first prima

191 ints (ICs) may be an important lever as they interfere with T-cell activation when activated by ICIs.

192 have demonstrated that chronic inflammation interferes with T-cell response and macrophage function

193 n addition, we found that activation of PKM2 interfered with TGF-beta1 signaling, which is necessary

194 Among other mechanisms, EDCs interfere with the action of steroidal and non-steroidal

195 m154 uses its cytoplasmic tail motif, DD, to interfere with the adaptor protein-1 (AP-1) complex, imp

196 ox-active reagents in the solution which can interfere with the antibiotics.

197 ptidase activity in these cells was shown to interfere with the assembly of mature divisomes, and con

198 n considerable interest for their ability to interfere with the bacterial communication process refer

199 cal three-dimensional structure, which might interfere with the binding and interaction with the effe

200 Strategies that interfere with the binding of the receptor programmed ce

201 for elucidating how BBS-causative mutations interfere with the biogenesis of the BBSome.

202 -adaptive changes in the brain, and this can interfere with the brain signals and behavior under cont

203 ovine serum, identified as albumin, does not interfere with the catalytic activity of soluble recepto

204 UbV targeting the E2 variant Ube2V1 did not interfere with the charging of its partner E2 enzyme but

205 ly, adverse effects of cancer therapies that interfere with the continuation of best-possible care, i

206 We posit that PCNA molecules trapped on DNA interfere with the correct metabolism of arrested replic

207 pot around the Ct-extension, where fragments interfere with the Ct conformational dynamics and inhibi

208 utrophils in the lung directly or indirectly interfere with the development of a protective Th1/Th17

209 ct kind of person-a way of thinking that can interfere with the development of children's own engagem

210 e suggests that secondary DNA structures may interfere with the dynamics of transit of the DNA throug

211 rbene that stabilize G-quadruplexes may also interfere with the elongation of telomeres and, in turn,

212 cts with low nanomolar affinity and does not interfere with the endogenous regulation of C3b depositi

213 We show that the double tag does not interfere with the essential functions of RanBP9.

214 ly, and awareness of such knowledge can even interfere with the exploitation thereof.SIGNIFICANCE STA

215 ts that are deposited into the cell wall and interfere with the host immune response.

216 and UTMD and microRNAs have the potential to interfere with the immune system, in this study we analy

217 The potential of these drugs to interfere with the inflammatory process by multiple path

218 argeting protein palmitoylation in AML could interfere with the leukemogenic potential and block MDSC

219 ting endogenous host proteins can be used to interfere with the localization and functioning of their

220 ZIP), a PKMzeta inhibitor, is widely used to interfere with the maintenance of acquired memories.

221 by effecting changes in host behaviour which interfere with the pathogen's ability to infect and re-i

222 lking with their patients about donating may interfere with the patient-physician relationship.

223 cause of their selectivity, vaccines did not interfere with the pharmacological effects of commonly u

224 contraception, not on medication that could interfere with the progestogen-only pill, and willing to

225 DPCs are bulky lesions that interfere with the progression of replication and transc

226 rogenic and immunosuppressive cytokines that interfere with the proper function of adaptive antitumor

227 While DVGs can interfere with the replication of nondefective (ND) viru

228 pod vector and suggest additional targets to interfere with the spirochete life cycle.

229 ptoms or treatments of medical disorders may interfere with the treatment of depression.

230 NF279 and NF449 interfered with the ability of the gp120 variable region

231 udies revealed that D/N Vif mutants directly interfered with the association of CBFbeta and wild-type

232 We found that the M466V mutation interfered with the association of CTNNBL1 with AID, res

233 teriostatic mechanism of action, and neither interfered with the autolytic effects of vancomycin.

234 Mhc promoter, while overexpressing circSamd4 interfered with the binding of PUR proteins to the Mhc p

235 ith a dominant-negative (D/N) phenotype that interfered with the function of wild-type Vif, inhibited

236 ppression of nuclear export of vRNP and also interfered with the host cellular cAMP and MEK/ERK casca

237 rated that the 7-hydroxycoumarin fluorophore interfered with the MIF-CD74 interaction and inhibited p

238 A inhibited PEPCK-M enzyme activity as 3-MPA interfered with the PEPCK enzyme assay, particularly at

239 Mechanistically, PGE(2) interfered with the phosphorylation of phospholipase C g

240 ng assays demonstrated that this interaction interferes with the ability of Ascl1 to bind DNA.

241 nally, we show that HCMV infection similarly interferes with the AP-1 complex.

242 (-)), a central intermediate of the N-cycle, interferes with the electrochemical determination of the

243 at distal regions, suggesting that neoGATA3 interferes with the fine tuning of ER-dependent gene exp

244 N6-methylated adenine at box D/D' interferes with the function of the coupled guide.

245 negative (D/N) Vif variants whose expression interferes with the function of virus-encoded wild-type

246 ght to impact many vital brain functions and interferes with the genesis and/or progression of numero

247 hat deletion of the conserved alpha-helix 30 interferes with the integrity of the cell wall, disrupts

248 We further showed that OR(His) interferes with the interaction between ARC3 and PARALOG

249 ts with the PYR1/PYL/RCAR and PP2C proteins, interferes with the interaction between PYR1/PYL4 and AB

250 oration with the chaperone protein Hfq, SgrS interferes with the interaction between the translation

251 lycosylated single-transmembrane sialomucin, interferes with the interactions between inflammatory ce

252 These results suggest that TA distinctly interferes with the lipid signaling and metabolism of PC

253 Mechanistically, amisyn interferes with the priming of secretory vesicles and th

254 Yen1, showing that its premature activation interferes with the response to perturbed replication.

255 nistic studies in vitro showed that neoGATA3 interferes with the transcriptional programs controlled

256 Moreover, interfering with the activity of APC/C did not lead to m

257 An inhibitor interfering with the activity of both kinases reduces ob

258 way to preserve the ridge dimension without interfering with the amount of new bone formation.

259 medium reacted quickly both with GO and MGO, interfering with the antibacterial potential and the deg

260 obably confers a dominant negative effect by interfering with the branching-inhibitory BRC1 genes.

261 s both innate and acquired immune responses, interfering with the development of protective immunity

262 e prevents at least some viral infections by interfering with the interaction of the virus with its r

263 agonists, and proteasome inhibitors without interfering with the known mechanism of action of these

264 However, interfering with the modulation of SNr cells does not im

265 Accordingly, interfering with the mTORC1/4E-BP/eIF4E axis inhibited t

266 Interfering with the oligomerization of P may represent

267 Interfering with the polymerase activity of Ena/VASP, it

268 Interfering with the Pygo2-H3K4me(2/3) interaction may t

269 Interfering with the timing of opa activity impacts the

270 een parental and offspring environments, and interfering with the transmission of parental cues to of

271 ai virus and respiratory syncytial virus) by interfering with the virus-induced cellular autophagy pa

272 under oxidizing conditions, thus potentially interfering with their ability to bind to MHC molecules.

273 ehavior in the association task, potentially interfering with their ability to generate group consens

274 ectively deprived of self-renewal ability by interfering with their epigenetic state.

275 nia either by destroying the platelets or by interfering with their generation via the process of meg

276 rowth, and adverse events in childhood might interfere with these processes and have long-lasting eff

277 etically modified an iron(II) chromophore to interfere with these specific atomic motions.

278 We propose that interfering with these pathways would modulate eosinophi

279 Interfering with these processes may provide a new strat

280 ity and promote viral dissemination and that interfering with these processes might reduce the likeli

281 llular protein kinases and phosphatases, and interfering with these signaling molecules can alter mem

282 that they use on a daily basis might somehow interfere with this communication, leading to unreliable

283 e during pheromone-gradient tracking and can interfere with this process, biasing the location of MPs

284 ied trifluoperazine (TFP) as a compound that interferes with this phenotype conversion.

285 vity in humans highlighting the potential of interfering with this pathway to treat vascular disease.

286 e how Serinc proteins prevent full fusion by interfering with this process.

287 The screen identified several compounds that interfere with transcription, DNA damage repair and the

288 olytic maturation of insulin proreceptors by interfering with transport of newly synthesized insulin

289 ly relevant compounds, including agents that interfere with tubulin dynamics and reduced cyst growth

290 that these interactions can be exploited to interfere with tumor metabolism and proliferation.

291 tralization sensitivity, V1 loop orientation interfered with V3 loop-directed bnAb binding.

292 ibilities for accelerating RT maturation and interfering with viral replication.

293 al role in the host's anti-viral defenses by interfering with viral replication.

294 hanistic studies demonstrate that three ISGs interfere with virus entry, six affect viral transcripti

295 ch factories provides a promising target for interfering with virus production.

296 ce of truncated MeCP2 in these mice does not interfere with wild-type MeCP2.

297 plasm formation and in virus replication and interferes with wild-type RV replication in coinfection.

298 Here we show that ZIKV-116 interferes with ZIKV infection at a post-cellular attach

299 These results suggest that interfering with ZNF274 binding at the maternal SNORD116

300 cause abnormally fast nuclear cleavages and interfere with zygotic transcription.