ライフサイエンスコーパス: interleukin-21

1 wnregulation of the T-cell effector cytokine interleukin 21.

2 T follicular helper cells (cTfh) expressing interleukin 21.

3 ecules interferon-gamma, interleukin-17, and interleukin-21.

4 expression is regulated by interleukin-6 and interleukin-21.

5 tched to IgG1 and IgG2b when stimulated with interleukin-21.

6 Similarly, CD4 T cell-secreted interleukin-21, a critical regulator of both peripheral

7 de-pulsed dendritic cells in the presence of interleukin-21 and enriched by peptide-major histocompat

8 SIV-infected rhesus macaques that sequential interleukin-21 and interferon alpha therapy generate ter

9 The cytokines interleukin-21 and interferon-gamma, which are secreted

10 specialization of CD4(+) T cells to produce interleukin-21 and promote antibody-mediated immunity an

11 pression was associated with interleukin 27, interleukin 21, and interferon gamma expression, rather

12 scriptional regulator Bcl6, the receptor for interleukin-21, and the ancestral polarity protein atypi

13 pecific CXCR5(+) CD4(+) T cells that secrete interleukin-21 are strongly associated with B cell memor

14 mediated by the cytokines interleukin-6 and interleukin-21 but is independent of TH1, TH2, and TH17

15 ning of calcium signaling, or treatment with interleukin-21 can correct mitochondrial defects and res

16 ls, IgM+CD21-/low-memory B cells, CD4+CXCR5+ interleukin 21+ cells, and T-helper 17 cells, compared w

17 f a pool of activated, and B cell-dependent, interleukin-21-expressing Vbeta4(+)CD4(+) T cells.

18 ), CD4+IL17A+ cells (P < .01), and CD4+CXCR5+interleukin 21+ follicular T-helper (Tfh) cells (P < .01

19 69+ Ag.pTfh, with induction of intracellular interleukin 21 (IL-21) and inducible costimulator (ICOS)

20 ophages were also analyzed for expression of interleukin 21 (IL-21) and negative regulators of immune

21 Interleukin 21 (IL-21) is a pleiotropic cytokine produce

22 Interleukin 21 (IL-21) is involved in regulating the exp

23 antigen-primed plasma cells failed to induce interleukin 21 (IL-21) or the transcriptional repressor

24 CD4(+) T cell-derived interleukin 21 (IL-21) sustains CD8(+) T cell responses

25 uantification of human and cynomolgus monkey interleukin 21 (IL-21) was developed, qualified, and imp

26 zed proximally to mutating B cells, secreted interleukin 21 (IL-21), induced expression of the transc

27 nsforming growth factor beta1 (TGFbeta1) and interleukin 21 (IL-21), produced by follicular helper T

28 Here, we show that interleukin 21 (IL-21), the archetypal follicular helper

29 efficacy of CD20-targeted therapy, we fused interleukin 21 (IL-21), which induces direct lymphoma cy

30 was uniquely dependent on iNKT cell-derived interleukin 21 (IL-21).

31 lly, Foxp1 directly and negatively regulated interleukin 21 (IL-21); Foxp1 also dampened expression o

32 was shown to be implicated in regulation of interleukin-21 (IL-21) and IL-17 secretion in mice and h

33 t specialized in helping B lymphocytes, with interleukin-21 (IL-21) and inducible costimulatory molec

34 ighlights the recent identification of human interleukin-21 (IL-21) and interleukin-21 receptor (IL-2

35 itically dependent on CD4(+) T cell help via interleukin-21 (IL-21) and that exploitation of this dev

36 mmac-dependent cytokine expression indicated interleukin-21 (IL-21) as a primary candidate optimizing

37 ould be treated by eliminating production of interleukin-21 (IL-21) by donor T cells or IL-21 recepto

38 Interleukin-21 (IL-21) can be produced by CD8 T cells fr

39 ronic HIV-1 control, it is not known whether interleukin-21 (IL-21) contributes to early HIV-1 immuni

40 Interleukin-21 (IL-21) controls the differentiation of T

41 e T-cell co-stimulator (ICOS) expression and interleukin-21 (IL-21) cytokine secretion.

42 Interleukin-21 (IL-21) enhances T helper 1 (Th1) and Th1

43 Interleukin-21 (IL-21) has been implicated in the develo

44 Interleukin-21 (IL-21) has broad actions on T and B cell

45 and indirect immune cell-mediated effects of interleukin-21 (IL-21) in mantle cell lymphoma (MCL), pr

46 y, we have examined the role of the cytokine interleukin-21 (IL-21) in regulating humoral immunity du

47 Interleukin-21 (IL-21) is a cytokine produced by activat

48 Interleukin-21 (IL-21) is a member of the type I cytokin

49 Interleukin-21 (IL-21) is a pleiotropic cytokine that in

50 Interleukin-21 (IL-21) is a proinflammatory cytokine tha

51 Interleukin-21 (IL-21) is a recently identified gamma-ch

52 Interleukin-21 (IL-21) is a T cell-derived cytokine that

53 Interleukin-21 (IL-21) is a type I cytokine that modulat

54 hronic viral infection, we demonstrated that interleukin-21 (IL-21) is an essential component of CD4+

55 The cytokine interleukin-21 (IL-21) is closely related to IL-2 and IL

56 Interleukin-21 (IL-21) plays important roles in regulati

57 phocytic leukemia (B-CLL) cells treated with interleukin-21 (IL-21) produce low levels of granzyme B.

58 In mice, CD4 cell-mediated interleukin-21 (IL-21) production is necessary for the m

59 -cell activation, as well as the addition of interleukin-21 (IL-21) to IL-7 and IL-15 to promote stem

60 Interleukin-21 (IL-21), a cytokine produced by many subs

61 urthermore, we identified a crucial role for interleukin-21 (IL-21), a cytokine secreted by intrathyr

62 Interleukin-21 (IL-21), a member of the IL-2 cytokine fa

63 Interleukin-21 (IL-21), a potent immunomodulatory four-a

64 teractions, was maintained by T-cell-derived interleukin-21 (IL-21), and promoted repeated rounds of

65 L) expressed on B cells and was dependent on interleukin-21 (IL-21), IL-6, and signal transducer and

66 In this study, we show that interleukin-21 (IL-21), likely produced by CD4+ T cells,

67 of chronic viral infection demonstrate that interleukin-21 (IL-21), produced primarily by CD4 T cell

68 found to increase SOX11 expression, whereas interleukin-21 (IL-21)-induced STAT3 activation or overe

69 found that a small subset of gp120-specific interleukin-21 (IL-21)-secreting CXCR5(+) CD4(+) T cells

70 eron-gamma and the T(FH)-associated cytokine interleukin-21 (IL-21).

71 S), immunogenicity, and biomarker profile of interleukin-21 (IL-21).

72 naive B cells to produce immunoglobulins via interleukin-21 (IL-21).

73 s help development of antibody responses via interleukin-21 (IL-21).

74 Our transcriptome analyses identify the interleukin 21 (IL21) gene (Il21) as a direct target of

75 expressed markers of Tfh cells and secreted interleukin 21 in response to HCV exposure.

76 ers have reported increased plasma levels of interleukin-21 in ITP.

77 on, and was not due to the overproduction of interleukin-21 in NOD mice.

78 issue of Immunity have identified a role for interleukin-21 in the development of these specialized c

79 se 1 dose-escalation study of membrane-bound interleukin 21 (mbIL21) expanded donor NK cells infused

80 with enhanced levels of SARS-CoV-2-specific interleukin-21 memory T cells (odd ratio, 3.84 [1.89-7.7

81 sed vaccine, we compared SARS-CoV-2-specific interleukin-21 memory T-cell and B-cell responses by enz

82 reviously unidentified mechanism mediated by interleukin-21/p38 mitogen-activated protein kinase/a di

83 notype (CD4(+) PD1(hi) CXCR5(hi)), function (interleukin 21 positive [IL-21(+)]), and gene expression

84 It remains unclear how interleukin-21 receptor (IL-21R) contributes to type 1 d

85 fication of human interleukin-21 (IL-21) and interleukin-21 receptor (IL-21R) deficiencies as novel e

86 This cluster co-expressed high levels of the interleukin-21 Receptor (IL-21R); Type-1 transcription f

87 Interleukin-21 receptor deficiency does not lead to redu

88 homozygous loss-of-function mutations in the interleukin-21 receptor gene (IL21R; c.G602T, p.Arg201Le

89 nary antitumor activity of recombinant human interleukin-21 (rIL-21).

90 Proliferation induced by CD40(+) interleukin-21 stimulation was completely blocked by CC-

91 ated Th1 follicular helper cells, and plasma interleukin-21, suggesting an alternative inflammatory m

92 unction, which was not enhanced by exogenous interleukin 21 supplementation in HIV-infected, older va

93 ly competent "Tfh-like" cells that expressed interleukin-21, Tfh cell markers, and Bcl6 and rescued G

94 Active production of both interleukin 27 and interleukin 21, together with production of interferon g