ライフサイエンスコーパス: interleukin-7

1 quiescent CD4 T cells (cultured with 2 ng/ml interleukin-7).

2 nd enhanced responsiveness of these cells to interleukin 7.

3 ion in response to various concentrations of interleukin 7.

4 s receiving alphaCD25 plus recombinant human interleukin-7.

5 receiving alphaCD25 and/or recombinant human interleukin-7.

6 important for LMP2A-mediated survival in low interleukin-7.

7 or when grown in methylcellulose containing interleukin-7.

8 and with Flt3-Ligand, stem cell factor, and interleukin-7.

9 ne negative mice when cultured in vitro with interleukin-7.

10 lated by the alpha-chain of the receptor for interleukin-7, a cytokine that stimulates B-cell lymphop

11 Using mice deficient in the interleukin 7-activated transcription factor STAT5, we d

12 Interleukin-2, interleukin-4, and interleukin-7 all utilize the common gamma (gamma c) rec

13 roliferation in response to stimulation with interleukin-7 alone.

14 stal structure of the unliganded form of the interleukin-7 alpha receptor (IL-7Ralpha) extracellular

15 owed hyperactivation of STAT5 in response to interleukin-7, an effect that was abrogated by the JAK1/

16 om use of the new immunomodulatory molecules interleukin 7 and anti-programmed cell death 1 in infect

17 generating pro-B colonies in the presence of interleukin 7 and flt3 ligand migrate to thymus-expresse

18 kine and TCR signals, such that signals from interleukin 7 and other common gamma-chain cytokines tra

19 hat two additional TGFbeta-stimulated genes, INTERLEUKIN-7 and CYCLIN D1, are dependent upon the inta

20 Patients with severe disease showed elevated interleukin-7 and increased T cell proliferation.

21 the Lyn kinase subfamily (key integrators of interleukin-7 and pre-BCR signaling) and the stage-speci

22 ocytes, increased in vitro responsiveness to interleukin-7, and increased in vitro gamma-interferon p

23 The cytokines interleukin-2, interleukin-7, and interleukin-15 increased the antivira

24 such as parathyroid hormone-related protein, interleukin-7, and interleukin-8 that can recruit or act

25 py with interleukin 2, interferon gamma, and interleukin 7 as an adjunct to drug treatment may improv

26 anied by decreased expression of enterocytic interleukin-7 as well as IEL interleukin-7Ralpha and tra

27 y-stimulating factor, interleukin-1beta, and interleukin-7) as well as soluble interleukin-2 receptor

28 a significant association between cord serum interleukin-7 at birth and the trajectories of children'

29 later decrease was predicted by the level of interleukin-7 at enrollment.

30 studies are needed before recombinant human interleukin 7 can be recommended for the treatment of ot

31 mplicates IFNgamma, IFNalpha, interleukin-2, interleukin-7, CTLA-4 (cytotoxic T-lymphocyte-associated

32 cient animals display a phenotype similar to interleukin-7-deficient animals in terms of lymphoid dev

33 both, FL and BM) to support the expansion of Interleukin-7 dependent pre-B cells from the BM.

34 e embryo fibroblasts or bone marrow-derived, interleukin 7-dependent pre-B cells accelerated their pr

35 Interleukin 7-dependent progenitor B-cell clones and lin

36 , we find that E2A proteins are required for interleukin 7-dependent proliferation due, in part, to a

37 SIM-Ig fusion proteins selectively increased interleukin 7-dependent proliferation of pre-B cells.

38 Furthermore, the cloning efficiency of interleukin-7-dependent B-cell precursors was increased

39 We have examined primary murine interleukin-7-dependent bone marrow-derived pro-B cells,

40 mals were able to proliferate in response to interleukin-7-dependent developmental signals in vitro.

41 ngle-chain antibody fragment leads for human interleukin-7 directly from unselected synthetic reperto

42 KIL depends on interleukin-7 for survival and proliferation and is NK1.

43 Interleukin-7 has been shown to enhance T cell reconstit

44 contrast, pre-BCR expression and escape from interleukin-7 have only modest effects on B cell develop

45 A novel recombinant interleukin-7/hepatocyte growth factor beta-chain (IL-7/

46 ronal differentiation under the influence of interleukin 7 (IL-7) alone or terminal differentiation a

47 or for TSLP consists of a heterodimer of the interleukin 7 (IL-7) alpha chain and a novel protein tha

48 The cytokines interleukin 7 (IL-7) and interleukin 4 (IL-4) regulate l

49 Interleukin 7 (IL-7) and its alpha-receptor, IL-7Ralpha,

50 Interleukin 7 (IL-7) and its receptor (IL-7R alpha) are

51 Interleukin 7 (IL-7) and T cell antigen receptor signals

52 unknown reasons requires signaling via both interleukin 7 (IL-7) and the T cell antigen receptor (TC

53 imilarities to FRCs but lacked expression of interleukin 7 (IL-7) and were identified as myofibroblas

54 thymic output is associated with breast milk interleukin 7 (IL-7) concentrations.

55 Among non-HMF infants, serum interleukin 7 (IL-7) had a marginally positive associati

56 Elevated levels of interleukin 7 (IL-7) have been correlated with various T

57 reactive TIL1383I TCR through culturing with interleukin 7 (IL-7) in the absence of CD3 activation.

58 ion and proliferated directly in response to interleukin 7 (IL-7) in vitro.

59 Interleukin 7 (IL-7) is a common gamma chain receptor cy

60 Interleukin 7 (IL-7) is critical in maintaining thymic-d

61 Interleukin 7 (IL-7) is the most potent thymopoietic cyt

62 Elevated serum interleukin 7 (IL-7) levels are observed in lymphopenic

63 Interleukin 7 (IL-7) promotes pre-B cell survival and pr

64 Interleukin 7 (IL-7) promotes the survival of TCRbeta(-)

65 We have shown here that interleukin 7 (IL-7) was an important survival factor fo

66 Here, we show that interleukin 7 (IL-7), a nonredundant cytokine that plays

67 in the presence of stem cell factor, Flt3-L, interleukin 7 (IL-7), and IL-3, isolated CD34+ cells dif

68 lation by endothelial cells does not involve interleukin 7 (IL-7), IL-15, CCL19, or CCL21.

69 Culturing CD34(+) progenitors with interleukin 7 (IL-7), IL-15, stem cell factor (SCF), FLT

70 Nuocytes required interleukin 7 (IL-7), IL-33 and Notch signaling for deve

71 osine-kinase (FL) + stem cell factor (SCF) + interleukin 7 (IL-7), or FL + thrombopoietin (Tpo).

72 Interleukin 7 (IL-7), which is required for T cell survi

73 cells in bone marrow due to complete loss of interleukin 7 (IL-7)-dependent B-cell progenitors.

74 Thymic stromal lymphopoietin (TSLP) is an interleukin 7 (IL-7)-like cytokine originally characteri

75 ein is the receptor for a recently described interleukin 7 (IL-7)-like factor, thymic stromal lymphop

76 sm for thymopoietic failure is damage to the interleukin 7 (IL-7)-producing thymic epithelial cells (

77 we show that developmental downregulation of interleukin 7 (IL-7)-receptor signaling in small pre-B c

78 Thymic ETPs were not interleukin 7 (IL-7)-responsive and generated B lineage

79 responsive to intrathymic cytokines such as interleukin 7 (IL-7).

80 Cotransfection of the interleukin 7 (IL-7)Ralpha chain cDNA resulted in conver

81 encoded by the E2A gene or the receptor for interleukin 7 (IL-7R) have severe overlapping defects in

82 d, with lower expression of the receptor for interleukin 7 (IL-7R).

83 Loss of interleukin-7 (IL-2) receptor expression has been descri

84 ment with the potent, antiapoptotic cytokine interleukin-7 (IL-7) accelerated neutrophil recruitment

85 bination of engineered, tumor matrix-binding interleukin-7 (IL-7) and IL-12 achieves remarkable antic

86 Although it is known that interleukin-7 (IL-7) and IL-15 influence the survival an

87 The ability of interleukin-7 (IL-7) and IL-15 to expand and/or augment

88 d two candidate immunostimulatory cytokines: interleukin-7 (IL-7) and IL-15.

89 of CD3-TCR and expanded with the addition of interleukin-7 (IL-7) and IL-15.

90 Pre-B-cell cultures require both soluble interleukin-7 (IL-7) and interactions with stromal cells

91 om the structural and biophysical studies of interleukin-7 (IL-7) and its alpha-receptor (IL-7Ralpha)

92 The interaction between interleukin-7 (IL-7) and its alpha-receptor, IL-7Ralpha,

93 Naive T cells are maintained by interleukin-7 (IL-7) and T cell receptor (TCR) signaling

94 n of the CD127 component of the receptor for interleukin-7 (IL-7) and the transcription factor c-myc.

95 chat et al report mutations in receptors for interleukin-7 (IL-7) and thymic stromal lymphopoietin (T

96 ike tyrosine kinase-3 (Flt3) ligand (FL) and Interleukin-7 (IL-7) are cytokines pivotal for B-cell de

97 Recent evidence has implicated interleukin-7 (IL-7) as a master regulator of T-cell hom

98 Interleukin-7 (IL-7) availability determines the size an

99 SCF in combination with interleukin-7 (IL-7) can also stimulate the combined mye

100 Interleukin-7 (IL-7) can boost CD4 T-cell counts, but op

101 Significant decreases in interleukin-7 (IL-7) colony forming units (CFU) were als

102 -7R) and are functionally less responsive to interleukin-7 (IL-7) compared with influenza-specific TR

103 e chemoattractant protein-1 (MCP-1) and peak interleukin-7 (IL-7) concentrations above the median, we

104 Interleukin-7 (IL-7) engages multiple mechanisms to over

105 als are dominated by cytokines, particularly interleukin-7 (IL-7) for murine developing B cells.

106 an bone marrow (BM) stromal cell contact and interleukin-7 (IL-7) for optimal proliferation has been

107 In normal T-cell development interleukin-7 (IL-7) functions as an antiapoptotic facto

108 The cytokine interleukin-7 (IL-7) functions to enhance lymphocyte pro

109 udy examined in murine models the effects of interleukin-7 (IL-7) given to young and middle-aged (9-m

110 Interleukin-7 (IL-7) has emerged as a central regulator

111 In mice, interleukin-7 (IL-7) hastens T-cell reconstitution and m

112 To study interleukin-7 (IL-7) in early thymocyte development, we

113 ce of pmel-1 T cells was highly dependent on interleukin-7 (IL-7) in irradiated mice, and IL-15 when

114 infected subjects receiving suppressive ART, interleukin-7 (IL-7) increases the number of CD4(+) T ce

115 Interestingly, while interleukin-7 (IL-7) induced both cell growth and increa

116 Interleukin-7 (IL-7) induces proliferation and different

117 ated orphan receptor gamma-t (RORgammat) and interleukin-7 (IL-7) influence gammadelta T cell homeost

118 Interleukin-7 (IL-7) inhibits TGF-beta signaling by up-r

119 Interleukin-7 (IL-7) is a cytokine that is required for

120 ional studies in CeD organoids revealed that interleukin-7 (IL-7) is a gluten-inducible pathogenic mo

121 Interleukin-7 (IL-7) is a homeostatic cytokine for resti

122 We show that interleukin-7 (IL-7) is a key regulator of glucose uptak

123 Interleukin-7 (IL-7) is a nonredundant cytokine that pla

124 Interleukin-7 (IL-7) is a potent immunotherapeutic agent

125 Given that interleukin-7 (IL-7) is a prospective therapeutic immuno

126 Interleukin-7 (IL-7) is a proteinaceous biological respo

127 Interleukin-7 (IL-7) is considered a critical regulator

128 Interleukin-7 (IL-7) is critical for T-cell development

129 Interleukin-7 (IL-7) is currently used in clinical trial

130 Interleukin-7 (IL-7) is essential to T-cell survival as

131 Interleukin-7 (IL-7) is fundamental for thymopoiesis, T-

132 Interleukin-7 (IL-7) is important for thymopoiesis in mi

133 Interleukin-7 (IL-7) is required for the establishment a

134 Interleukin-7 (IL-7) is the major thymopoietic cytokine.

135 Although elevated interleukin-7 (IL-7) levels have been reported in patien

136 We examined the effects of exogenous interleukin-7 (IL-7) on apoptosis, proliferation, and th

137 meostatic proliferation of infected cells by interleukin-7 (IL-7) or antigenic stimulation, as well a

138 Previously we reported that withdrawal of interleukin-7 (IL-7) or IL-3 produced a rapid intracellu

139 Interleukin-7 (IL-7) plays a crucial role in cell surviv

140 We show that interleukin-7 (IL-7) plays multiple roles in regulating

141 Interleukin-7 (IL-7) potently enhanced thymic-independen

142 ed increased numbers of TECs and intrathymic interleukin-7 (IL-7) production and reorganization of co

143 Soluble interleukin-7 (IL-7) receptor alpha (sCD127) is implicat

144 The antiapoptotic function of the interleukin-7 (IL-7) receptor is related to regulation o

145 Interleukin-7 (IL-7) receptor signaling begins with acti

146 The infection caused a downregulation of the interleukin-7 (IL-7) receptor, needed for survival of co

147 te lymphoid cell-mediated inflammation in an interleukin-7 (IL-7) receptor-, S1P receptor 1-, and CCR

148 Surface expression of interleukin-7 (IL-7) receptor-alpha (IL-7R alpha), a com

149 geny of My-bi HSCs express lowered levels of interleukin-7 (IL-7) receptor.

150 Interleukin-7 (IL-7) regulates T-cell homeostasis, and i

151 -BCR-mediated functions, leading to enhanced interleukin-7 (IL-7) signaling and elevated levels of RA

152 Although absence of interleukin-7 (IL-7) signaling completely abrogates T an

153 naive CD4(+) T cells to T-cell receptor and interleukin-7 (IL-7) stimulation were evaluated by using

154 early preB-I cells that required stromal and interleukin-7 (IL-7) support for growth in vitro.

155 Interleukin-7 (IL-7) supports the growth and chemoresist

156 med larger colonies in cultures treated with interleukin-7 (IL-7) than control bone marrow B cells di

157 d (FL) has a unique ability to interact with interleukin-7 (IL-7) to directly and selectively promote

158 ty of hematopoietic growth factors including interleukin-7 (IL-7), a cytokine critical for murine B-c

159 Interleukin-7 (IL-7), a cytokine produced by stromal cel

160 hese MTI-mediated effects can be reversed by interleukin-7 (IL-7), an important regulator of early B-

161 a loss of intestinal epithelial cell-derived interleukin-7 (IL-7), and this loss may play an importan

162 erm immunity against reinfection and require interleukin-7 (IL-7), but the mechanisms by which IL-7 c

163 ors were cultured in limiting dilutions with interleukin-7 (IL-7), flt3 ligand (FL), c-kit ligand (KL

164 thymocytes cultured in methylcellulose with interleukin-7 (IL-7), IL-15, and steel factor (SF) forme

165 ed by CD3/CD28 engagement in the presence of interleukin-7 (IL-7), IL-21, and the glycogen synthase-3

166 Exogenous Interleukin-7 (IL-7), in supplement to antiretroviral th

167 ional granulocyte colony-stimulating factor, interleukin-7 (IL-7), or IL-3alpha receptor.

168 nt rabies virus (RABV) that expressed murine interleukin-7 (IL-7), referred to here as rLBNSE-IL-7, w

169 common gamma-chain cytokines (CGCC), such as interleukin-7 (IL-7), render resting CD4 T cells permiss

170 Interleukin-7 (IL-7), the principal homeostatic cytokine

171 nsion of early lymphoid progenitors requires interleukin-7 (IL-7), which functions through gamma(c)-m

172 Interleukin-7 (IL-7)-deficient mice exhibit an early def

173 We established a human interleukin-7 (IL-7)-dependent T-ALL cell line, TAIL7, t

174 We characterize the interleukin-7 (IL-7)-induced stimulation of primary huma

175 Precise mechanisms underlying interleukin-7 (IL-7)-mediated tumor invasion remain uncl

176 y role in the regulation of T-cell levels is interleukin-7 (IL-7).

177 source of lymphopoietic factors that include interleukin-7 (IL-7).

178 11 (45- to 338-fold), RANTES (724-fold), and interleukin-7 (IL-7; 128-fold).

179 ression of multiple hematopoietic cytokines (interleukin-7 [IL-7], Flt3L, stem cell factor [SCF], ThP

180 CXCR4 was required for CLP positioning near Interleukin-7(+) (IL-7) cells and for optimal IL-7 recep

181 Using interleukin 7 (IL7) as a prototypic secreted factor, we

182 line with this, we here show that endogenous interleukin 7 (IL7) can increase the expression of the o

183 Interleukin-7 (IL7) is a hematopoietic cytokine with cri

184 ssful compassionate use of recombinant human interleukin 7 in a patient with idiopathic CD4+ T-cell l

185 r fetal thymocytes, but was not as potent as interleukin 7 in lobe submersion cultures.

186 al to transform primary mouse pro-T cells to interleukin-7-independent growth and were not affected b

187 he growth hormone pathway, and the cytokines interleukin-7, interleukin-12, and interleukin-15 indica

188 eceptor-alpha, interleukin-4, interleukin-5, interleukin-7, interleukin-13, interleukin-17, macrophag

189 cells in vitro in the presence of cytokines (interleukin-7, interleukin-15, stem cell factor, and fms

190 Interleukin-7 is widely accepted as a major homeostatic

191 emonstrate in 2 patients that treatment with interleukin 7, JC polyomavirus (JCV) capsid protein VP1,

192 e time of their IRIS events and higher serum interleukin-7 levels, suggesting that the T-cell populat

193 thymic stromal lymphopoietin, an epithelial interleukin 7-like cytokine that enhanced the B cell 'li

194 In mature thymocytes, TAK1 was required for interleukin 7-mediated survival and T cell receptor-depe

195 Interferon-alpha and -beta inhibit the interleukin-7-mediated growth and survival of T and B ly

196 ynaptic structure, synapse organization, and interleukin-7-mediated signaling pathways.

197 r-old man was treated with recombinant human interleukin 7 on November 1, 2012.

198 egulation of immune-related proteins such as Interleukin-7, Oncostatin M, and VEGFA in carriers of rs

199 factors such as keratinocyte growth factor, interleukin 7 or sex steroid ablation for therapeutic th

200 yte cell lines dependent on interleukin-3 or interleukin-7, or primary lymphocytes dependent on inter

201 T cells (P = 0.05) and circulating levels of interleukin-7 (P = 0.007) were increased compared to con

202 on that is distinguished by requirements for interleukin-7, Pax5, and Ezh2 for rearrangement of the V

203 mainly memory T cells, which correlated with interleukin-7 plasma levels.

204 populations during immune responses, whereas interleukin-7 plays a singularly dominant role, in terms

205 The intrathymic injection of interleukin-7 prior to irradiation conferred radioprotec

206 red human DCs to synthesize B2M that induced interleukin-7 production by thymic epithelial cells and

207 aneous (s/c) injections of recombinant human interleukin 7 (r-hIL-7) is safe and improves immune CD4

208 set by the proper signaling function of the interleukin 7 receptor (IL-7R) and the pre-T-cell antige

209 The molecular crosstalk between the interleukin 7 receptor (IL-7R) and the precursor to the

210 he pre-B cell antigen receptor (pre-BCR) and interleukin 7 receptor (IL-7R) coordinate pre-B cell pop

211 t to express TCRs can be subdivided based on interleukin 7 receptor (IL-7R) expression.

212 Mice lacking the interleukin 7 receptor (IL-7R) generate alpha/beta T cel

213 (pre-BCR) and escape from signaling via the interleukin 7 receptor (IL-7R).

214 In interleukin 7 receptor (IL-7R)alpha-/- murine thymocytes

215 There was downregulation of interleukin 7 receptor (IL7R) (P = .0001) and chemokine

216 Here, we show that interleukin 7 receptor (IL7R) interacts with the chemoki

217 The interleukin 7 receptor (IL7R), which contains a unique a

218 ineage potential was largely associated with interleukin 7 receptor alpha (IL-7R(alpha)) expression a

219 Up-regulation of the B-cell line 2, interleukin 7 receptor alpha and interleuking 2 receptor

220 face expression and RNA levels of CD127, the interleukin 7 receptor alpha chain (IL-7Ralpha).

221 n of a polymorphism in the gene encoding the interleukin 7 receptor alpha chain (IL7R) as a significa

222 o1 deficiency resulted in a severe defect in interleukin 7 receptor alpha-chain (IL-7Ralpha) expressi

223 udy we show that increased expression of the interleukin 7 receptor alpha-chain (IL-7Ralpha) identifi

224 The interleukin 7 receptor alpha-chain (IL-7Ralpha) is essen

225 nnate lymphoid cells (ILCs) that express the interleukin 7 receptor alpha-chain (IL-7Ralpha).

226 cells had markedly reduced expression of the interleukin 7 receptor and exhibited shorter survival.

227 ed fraction of CD8(+) T cells expressing the interleukin 7 receptor at the peak of the response.

228 ), a linchpin in the pre-B-cell receptor and interleukin 7 receptor signaling pathways critical to B-

229 ry receptors (inducible T-cell costimulator, interleukin 7 receptor), whereas inhibitory receptors (p

230 , a c-Kit(hi) progenitor subset positive for interleukin 7 receptor-alpha (IL-7Ralpha) emerged that h

231 pro-B cell stage due to a failure to express interleukin 7 receptor-alpha.

232 e show that neonatal thymi transplanted into interleukin 7 receptor-deficient hosts harbor population

233 have demonstrated that downregulation of the interleukin-7 receptor (CD127) distinguishes Treg cells

234 hed by progressively lower expression of the interleukin-7 receptor (IL-7R alpha) and by lower IL-7 r

235 sident memory (TRM) cells, but low levels of interleukin-7 receptor (IL-7R) and are functionally less

236 4(+) T cells and in reduced abundance of the interleukin-7 receptor (IL-7R) encoded by the NF-kappaB

237 Furthermore, we show that ectopic interleukin-7 receptor (IL-7R) expression can rescue pre

238 One unexpected result was the high level of interleukin-7 receptor (IL-7R) gene expression in HS-27a

239 The interleukin-7 receptor (IL-7R) is a crucial T-cell devel

240 Interleukin-7 receptor (IL-7R) levels are tightly contro

241 group is enriched for genes involved in the interleukin-7 receptor (IL-7R) pathway and T cell recept

242 Although the interleukin-7 receptor (IL-7R) plays a pivotal role in A

243 The interleukin-7 receptor (IL-7R), via its activation of th

244 Here, we show that c-Kit and interleukin-7 receptor (IL-7R)-mediated signals support

245 Expression of the interleukin-7 receptor (IL-7Ralpha) chain marks function

246 tes from mice lacking the alpha-chain of the interleukin-7 receptor (IL-7Ralpha).

247 of normal and malignant thymocytes carrying interleukin-7 receptor (IL7R) gain-of-function mutations

248 Human soluble interleukin-7 receptor (sIL7R)alpha circulates in high m

249 Interleukin-7 receptor a (encoded by IL7R) is essential

250 only high levels of PD-1 but also decreased interleukin-7 receptor alpha (CD127), an exhausted pheno

251 factor receptor (G-CSFR); and were uniformly interleukin-7 receptor alpha (IL-7Ralpha(-)) AA4.1(Lo),

252 e memory cells without undergoing changes in interleukin-7 receptor alpha (IL-7Ralpha) expression, di

253 Interleukin-7 receptor alpha (IL-7Ralpha) is essential f

254 (Th) cell subsets, ILC subsets positive for interleukin-7 receptor alpha (IL-7Ralpha) produce distin

255 The interleukin-7 receptor alpha (IL-7Ralpha) signaling path

256 ular or to the transmembrane domain (TMD) in interleukin-7 receptor alpha (IL7R) or cytokine receptor

257 elayed T cell responses and decreased CD127 (interleukin-7 receptor alpha [IL-7Ralpha] chain) convers

258 onstrated to regulate the gene expression of interleukin-7 receptor alpha chain (IL-7Ralpha) and post

259 t critically regulates the expression of the interleukin-7 receptor alpha chain (IL-7Ralpha) in T cel

260 Interleukin-7 receptor alpha chain (IL-7Ralpha) is induc

261 increased MS risk is the soluble form of the interleukin-7 receptor alpha chain gene (sIL7R) produced

262 of CD45RB and upregulated expression of the interleukin-7 receptor alpha chain, indicating a transit

263 Furthermore, expression of the interleukin-7 receptor alpha chain, which has been propo

264 x10(-8)), as were a nonsynonymous SNP in the interleukin-7 receptor alpha gene (IL7RA) (P=2.94x10(-7)

265 Moreover, we determined that dex upregulated interleukin-7 receptor alpha on CAR T cells and increase

266 d- (CD62L-) CC chemokine receptor 7- (CCR7-) interleukin-7 receptor alphaLo (IL-7RalphaLo) phenotype.

267 memory precursors (expressing high levels of interleukin-7 receptor and low levels of killer cell lec

268 cell expansion is driven by signals from the interleukin-7 receptor and the pre-B-cell receptor and i

269 Mice lacking interleukin-7 receptor are lymphopenic, due to a defect

270 Thus ligands of the interleukin-7 receptor deliver an extrinsic signal that

271 f PU.1 as a transcriptional regulator of the interleukin-7 receptor has established one mechanism by

272 We show that activating mutations in the interleukin-7 receptor identified in human pediatric ETP

273 , effector CD8(+) T cells differentiate into interleukin-7 receptor(lo) (IL-7R(lo)) short-lived effec

274 w) cells express B cell leukemia/lymphoma 2, interleukin-7 receptor, and CD5.

275 haracterized by selective down-regulation of interleukin-7 receptor, heightened apoptosis, and poor a

276 apid apoptosis, and failed to upregulate the interleukin-7 receptor, known to be important for T cell

277 ated polyfunctional T helper cells with high interleukin-7 receptor, rapid clonal expansion, and pote

278 vitamin D(3), including genetic variants in interleukin-7 receptor-alpha (IL7RA*C), interleukin-2 re

279 ated STAT5 and high expression levels of the interleukin-7 receptor-alpha and interleukin-15 receptor

280 Functional studies validated interleukin-7 receptor-alpha as a Foxo1 target gene esse

281 Mechanistically, excessive surface interleukin-7 receptor-alpha sequestrates the common gam

282 D4+ T cells lacking autophagy show increased interleukin-7 receptor-alpha surface expression, while n

283 Interleukin-7 receptor-alpha, a cytokine receptor mostly

284 Accordingly, populations of CD62L(high) interleukin-7 receptor-positive progenitor central memor

285 Activating mutations of interleukin-7-receptor pathway genes (IL-7Rp) play a pro

286 t three differentially regulated domains: an interleukin-7-regulated domain consisting of the 5' J558

287 rrow, treatment of isolated pro-B cells with interleukin-7 resulted in a dramatic increase in express

288 Administration of recombinant human interleukin-7 (rhIL-7) to mice increases the exportation

289 tent of TSCM generation might correlate with interleukin 7 serum levels.

290 In contrast, mice deficient for interleukin-7 show a severe lymphopenia in most lymphoid

291 gments has been suggested to be regulated by interleukin 7 signaling in pro-B cells.

292 ric domains in response to downregulation of interleukin 7 signaling.

293 efect in the assembly of antigen receptor or interleukin-7 signaling.

294 that elicits the release of c-KIT ligand and interleukin-7 that greatly accelerate posttransplant imm

295 eukin-7, or primary lymphocytes dependent on interleukin 7, the phosphatase Cdc25A is the critical me

296 a cells in the presence of interleukin-2 and interleukin-7, the CD34+ cells developed two types of B2

297 genitor, the alpha chain of the receptor for interleukin-7 was not detected by fluorescence-activated

298 interleukin 6 [IL-6], and soluble CD14) and interleukin 7 were measured at antiretroviral therapy (A

299 d concentrations of the homeostatic cytokine interleukin-7, which led to local and systemic activatio

300 granzyme B, tumor necrosis factor-alpha, and interleukin-7 while abrogating transforming growth facto