ライフサイエンスコーパス: interlock

1 ding domains arranged so that the bricks can interlock.

2 methyllanthionine rings, three of which are interlocking.

3 aged to promote the oxidative addition of an interlocked 1,3-diyne to a rhodium(I) center.

4 ically trivial macrocycle (unknot), a doubly interlocked [2]catenane (Solomon link) and a knot with s

5 at is topologically isomeric with the doubly interlocked [2]catenane.

6 hanical bonding, in isomeric [3]- and doubly interlocked [2]catenanes controls the formation of TTF r

7 property, the first examples of mechanically interlocked [2]rotaxanes containing ChB-donor groups are

8 the free volume required for rotation of the interlocked 24C6 macrocycle, but the frameworks are inte

9 regio- and diastereoselective manner, giving interlocked 3,4-disubstituted trans-azetidin-2-ones.

10 ng another precursor to engage in subsequent interlocking(3-9).

11 re was achieved with standardized continuous interlocking 6-0 PTFE sutures, while in the "cyanoacryla

12 We discover that a 'nano-interlock' adhesion mechanism is responsible for the adh

13 al grids forming channels decorated with the interlocked alkenyl threads.

14 This interlocking analysis of IFN-inducible genes, plasma ana

15 two RS-[Au-SR]3 and two RS-[Au-SR]4 motifs, interlocked and capping on a prolate Au8 core.

16 ometry provides insight into the topology of interlocked and knotted molecules, even when they exist

17 mplex demonstrates that the two hexamers are interlocked and misaligned along the DNA axis and lack A

18 e data provide a powerful model to probe the interlocking and synergistic network of the circadian cl

19 d microstructure of which provide mechanical interlocking and toughening at critical strains, while a

20 This elaborate interlocked anion receptor functions via a novel dynamic

21 posed, including parallel, antiparallel, and interlocked antiparallel stacking conformations.

22 lic Hamilton-like receptor (2b), leads to an interlocked architecture, which was isolated and fully c

23 olecular machines because their mechanically interlocked architectures enable them to contract and ex

24 nd supramolecular cages, open frameworks and interlocked architectures.

25 delled from en-face contacts at fusion to an interlocking arrangement after fusion, and demonstrate t

26 bones connecting in either an abutting or an interlocking arrangement, reflecting the evolutionary di

27 Highly stable permanently interlocked aryleneethynylene molecular cages were synth

28 coated with a shell of organic ligands that interlock as spacers and provide tensile strength.

29 Our analysis reveals that the level of interlocking, as measured by a contraction of the latent

30 The appendages form an interlocked assembly attaching the tail around the colla

31 l barbules, the latter with hooklets forming interlocking barbs.

32 The cooperative slide-and-interlock behavior of the VS domains described by the VS

33 5-HT2CR tone confers vulnerability to these interlocked behaviors.

34 with a triangular cross-section composed of interlocked beta-sheets from each of the three chains.

35 ntually promote the generation of mechanical interlocking between the adventitious roots of English i

36 the coordination-driven self-assembly of the interlocked bis-metallacage, by the 90 degrees Pt(II) he

37 random stacking of metal layers amongst the interlocking boron layers.

38 ricks") consists of two 3D printed parts: an interlocking "brick" that contains a selected number of

39 three-helix bundles of which two helices are interlocked by conserved arginine-glutamate (Arg-Glu) io

40 on top of the Bone Portion using mechanical interlocking by designing specific knobs in the 3D print

41 Two adjacent interlocked cages were covalently married together by in

42 ajor part of the capsid surface is formed by interlocking capsid protein (CA) hexamers.

43 We now show that mechanically interlocked catalytic rings can effectively regulate the

44 uster formation, as the cyclic components in interlocked catenane and rotaxane structures, for constr

45 OFs can be tuned by judicious control of the interlocked chain length, which was further analyzed by

46 Interlocked challenges of climate change, biodiversity l

47 Interlocked circular DNA nanostructures, e.g., catenanes

48 The interlocked complexes are predominantly formed in the re

49 domain specifically prevent assembly of the interlocked complexes without inactivating either RcsF o

50 tinue by showing how to include mechanically interlocked components in MOFs, and analyse the distinct

51 ween the positively charged and mechanically interlocked components results in the adoption of a co-c

52 nor-acceptor systems allows the study of the interlocked components' submolecular motions and conform

53 ciently large to prevent dissociation of the interlocked components, the strained SREP-ext stereoisom

54 In mechanically interlocked compounds, such as rotaxanes and catenanes,

55 A sequence of successive, interlocking conformational changes guides the two subst

56 r composite parts with integrated mechanical interlocking connections.

57 compromised redox stability compared to its interlocked counterpart.

58 r templating interactions, three-dimensional interlocked covalent architectures remain difficult to p

59 a lever that accelerates the dissociation of interlocked covalent bonds.

60 ffinity of a remote recognition site for the interlocked crown ether ring through electrochemical sti

61 rbonaceous chondrite to demonstrate that the interlocking crystal arrangement formed within a sodium-

62 of a stable, neutral, monomeric mechanically interlocked Cu(I) triazolide under aqueous conditions.

63 sis, and permitted by the reduction of high, interlocking cusps(10-12).

64 omo[2]catenane comprised of two mechanically interlocked cyclobis(paraquat-p-phenylene) rings has bee

65 atenane HC(*7+)-composed of two mechanically interlocked cyclobis(paraquat-p-phenylene) rings-with "z

66 the other hand, HIV-1 infection induced more interlocked cytokines network, establishing new strong c

67 rizes the progress made towards mechanically interlocked daisy chains.

68 , and quench-crystallized to form spheres of interlocking dendritic crystals primarily of magnetite (

69 sition from prometaphase to G1, we reveal an interlocking dephosphorylation switch coordinating E2F8

70 describe the strategies towards mechanically interlocked derivatives of single-walled carbon nanotube

71 nism of communication is enabled by a unique interlocked design, which effectively removes the cataly

72 The installation of interlocked dicarba bridges into peptide sequences requi

73 rm 4 is a zero-nucleotide loop monomer or an interlocked dimer.

74 distances are in approximate agreement with interlocked dimers observed previously by crystallograph

75 In several interlocking discrimination experiments with three male

76 is a chain mail-like network of two types of interlocked DNA molecules: a few dozen ~23-kb maxicircle

77 o reversibly operate mechanical motion in an interlocked DNA nanostructure opens exciting new avenues

78 Here we report the design of an interlocked DNA nanostructure that is able to fine-tune

79 prospectives and challenges in the field of interlocked DNA nanostructures and the possible applicat

80 nosome mitochondrial genome, is a network of interlocked DNA rings including several thousand minicir

81 etoplast DNA (kDNA), is a massive network of interlocked DNA rings, including several thousand minici

82 s a DNA network composed of several thousand interlocked DNA rings.

83 d as a single, massive DNA network formed of interlocked DNA rings.

84 Interlocked DNA rotaxanes and their different synthetic

85 a versatile tool for the formation of larger interlocked dsDNA nanostructures, like rotaxanes and cat

86 y loosely topographically organized, forming interlocking feed-forward and feed-back inhibitory circu

87 of activity by a self-regulating network of interlocked feedback and feedforward loops.

88 and suggest that the primary function of the interlocked feedback loop in Drosophila is to drive rhyt

89 CLK-CYC also activates an interlocked feedback loop, which uses the PAR DOMAIN PRO

90 roach was then applied to a model describing interlocked feedback loops governing the synthesis of th

91 oscillator of the plant clock is composed of interlocked feedback loops that involve multiple repress

92 on mutual translational repression, act via interlocked feedback loops to provide robustness to this

93 els, consistent with dynamical properties of interlocking feedback architecture in eukaryotes.

94 The interlocking feedback loop mechanism of the clock is con

95 d by a transcriptional regulatory network of interlocking feedback loops acting on the transcription

96 Biological systems are composed of countless interlocking feedback loops.

97 dve is a shared component of two opposing, interlocked feedforward loops (FFLs).

98 This interlocked FFL motif may be a general mechanism to cont

99 electron microscopy directly reveal that the interlocking fibrous building blocks further retard crac

100 ging using squaraine rotaxane endoperoxides, interlocked fluorescent and chemiluminescent dye molecul

101 In such magmas, crystals form an interlocking framework when their content reaches critic

102 es enantiodiscrimination compared to the non-interlocked free axle and macrocycle components.

103 This suggests an interlocking gate mechanism for DNA transport both into

104 example, is controlled by a set of fourteen interlocking genes called the retinal determination (RD)

105 present a one-pot green method to synthesize interlocked graphene-Prussian Blue hybrid composites as

106 We conclude that the interlocked helices of LHCII form a rigid core.

107 The conformations of the Arg residues that interlock helix A and B appear to be preserved in the li

108 Interlocking hexagonal subunit assemblies containing 3 a

109 The application of chiral interlocked host molecules for discrimination of guest e

110 t influence of ChB in anion binding by these interlocked host systems.

111 rison to the acyclic XB receptor, due to the interlocked host's unique three-dimensional binding cavi

112 faster than its noninterlocked or uncoupled interlocked (i.e., pulled from both sides of the axle) c

113 bules branch off the barbs, allowing them to interlock in a tight zipper-like fashion to form vanes.

114 strand comprises "open" CHMP1B subunits that interlock in an elaborate domain-swapped architecture an

115 es between the ketone and the carbanion both interlocked in a tautomeric equilibrium.

116 Simultaneously, it uses diverse, interlocking insider and outsider instrumental strategie

117 E sequences fold cooperatively and form interlocking interfaces with G5 domains in a head-to-tai

118 llowed by a slow step in which intermediates interlock into capsids.

119 e main wall carbohydrate polymers, which are interlocked into the supramolecular wall structure throu

120 Interlocking is maintained throughout the entirety of de

121 ep that element distinct from larger, though interlocking, issues concerning the nature of adaptive o

122 t species best known for its broad muzzle of interlocking, lancet-shaped teeth, is almost completely

123 The interlocked linker was obtained by the hydrogen bond-dir

124 ic frameworks (MTV-MOFs) by preincorporating interlocked linkers into framework materials.

125 ghly complex jigsaw-puzzle-shaped cells with interlocking lobes.

126 The architecture surrounding the interlocking loops contributes to the stability of the p

127 kits' derived from pRNA structural features: interlocking loops for hand-in-hand interactions, palind

128 ractions, and sequence variation outside the interlocking loops may counterbalance the changes in the

129 synthesis of a poly-[n]-catenane composed of interlocked M(12)L(8) icosahedral nanometric cages (i.e.

130 cationic compounds without an ion sheltering interlocked macrocycle (dumbbells).

131 ith void space that allows for motion of the interlocked macrocycle inside the MOF pores, while the m

132 where the molecular chains consist solely of interlocked macrocycles, contain one of the highest conc

133 Catenanes - molecules consisting of interlocked macrocyclic rings - have been prepared by te

134 none unit and a 1,5-diaminonaphthalene unit, interlocked mechanically by cyclobis(paraquat-p-phenylen

135 very different potential recognition sites, interlocked mechanically with the tetracationic cyclopha

136 eficient 4,4'-bipyridinium (BIPY(2+)) units, interlocked mechanically with the tetracationic cyclopha

137 -patch adhesion in combination with a steric interlock mechanism that selects the required staggered

138 Beyond the basic interlocking mechanism, we also consider the intricate a

139 These results reveal complementary, interlocking mechanisms for regulation of autophagy by n

140 An interlocking mechanistic picture of an insertion and a f

141 Here, we investigate plasma separation on interlocked micropillar scaffolds ("synthetic paper") by

142 cubes via chemical bonding to form a kind of interlocked microstructure with high stability and good

143 anion-templated synthesis of macrocycles and interlocked molecular architectures, while the study of

144 the rational synthesis of other higher-order interlocked molecular architectures.

145 information is critical for the creation of interlocked molecular machines that have predictable ene

146 Three-terminal interlocked molecular species were obtained by dynamic (

147 een prepared, each containing a mechanically interlocked molecule (MIM) as the linker and a copper(II

148 ve been prepared that contain a mechanically interlocked molecule (MIM) as the pillaring strut betwee

149 the incorporation of a bistable mechanically interlocked molecule (MIM) into a robust Zr-based metal-

150 cient method for constructing a mechanically interlocked molecule in unprecedented near quantitative

151 mplated synthesis of a lanthanide-containing interlocked molecule is demonstrated by utilizing a nitr

152 properties of the higher-order mechanically interlocked molecule.

153 e ability of CB-AAC to generate mechanically interlocked molecules (MIMs) - in particular, rotaxanes

154 rotocols to afford a variety of mechanically interlocked molecules (MIMs) and ultimately (ii) on the

155 At equilibrium, these Mechanically Interlocked Molecules (MIMs) undergo thermally activated

156 Sophisticated mechanically interlocked molecules (MIMs) with interesting structures

157 Since the advent of mechanically interlocked molecules (MIMs), many approaches to templat

158 lective behaviour of switchable mechanically interlocked molecules (MIMs)--specifically, bistable rot

159 ng processes for these types of mechanically interlocked molecules (MIMs).

160 focus, however, on the functional aspects of interlocked molecules and discuss how these can find app

161 erging as an important class of mechanically interlocked molecules and have attracted much attention

162 particularly in the context of mechanically interlocked molecules and increases our fundamental unde

163 and interactions play in modern syntheses of interlocked molecules and materials, with a particular f

164 Mechanically interlocked molecules are likely candidates for the desi

165 These mechanically interlocked molecules are prepared by stoppering kinetic

166 r dynamics and illustrate the versatility of interlocked molecules as scaffolds for the organization

167 We propose that mechanically interlocked molecules be inserted covalently into the ri

168 Squaraine rotaxanes are mechanically interlocked molecules comprised of a dumbbell shaped squ

169 le to template the formation of mechanically interlocked molecules has led to the design and synthesi

170 is an approach that integrates mechanically interlocked molecules into complex three-dimensional (3D

171 somers in the case of all three mechanically interlocked molecules investigated.

172 Multiple Fe(II) cation coordination by the interlocked molecules is crucial: the demetalated catena

173 Interlocked molecules possess properties and functions t

174 ystems such as bundles, grids, helicates and interlocked molecules that are not synthetically accessi

175 Mechanically interlocked molecules that change their conformation in

176 In donor-acceptor mechanically interlocked molecules that exhibit bistability, the rela

177 Flexibility in pseudorotaxanes and interlocked molecules that rely on interactions between

178 didates for the design of novel mechanically interlocked molecules with new properties.

179 rategy for the incorporation of mechanically interlocked molecules within porous materials circumvent

180 tance of the Cu(i) ion (used to assemble the interlocked molecules) as an electronic relay in the pho

181 s the macromolecular version of mechanically interlocked molecules, mechanically interlocked polymers

182 Mechanically interlocked molecules, owing to the particular kind of c

183 ngly simple way of constructing mechanically-interlocked molecules, such as rotaxanes, catenanes, Bor

184 es and catenanes are the leading examples of interlocked molecules, whose recent developments in synt

185 the study of precision-engineered oligomeric interlocked molecules.

186 sponsive molecular switches and mechanically interlocked molecules.

187 al moment in the development of the field of interlocked molecules.

188 s approach can be combined with mechanically interlocking molecules to produce nanocapsules that are

189 unique helical microstructure consisting of interlocking nanofibres.

190 tacking sequences), interwoven nanotwins and interlocked nanograins.

191 aracterization of the different mechanically interlocked nanographenes evidence enhanced thermal and

192 It has been proven that the mechanically interlocked nature of the [3]catenanes facilitates the f

193 The kernel structure unbiasedly reveals four interlocked negative feedback loops contributing to circ

194 In the fruit fly Drosophila melanogaster, interlocked negative transcription/translation feedback

195 suggest that the regulatory network contains interlocked network motifs consisting of a positive feed

196 gulators are arranged together in a complex, interlocking network with many seemingly redundant and o

197 olecules, sheltering the ionic cores with an interlocked neutral macrocycle has considerable effect o

198 ein, we report the synthesis of mechanically interlocked nitrogenated nanographenes.

199 n these two metals in addition to mechanical interlocking observed at a larger scale.

200 olyammonium species enabled coordination and interlocking of diolefin polyether fragments around the

201 Mechanical interlocking of molecules (catenation) is a nontrivial c

202 This work demonstrates the successful interlocking of sequestration-based ultrasensitivity and

203 The dimeric RHH fold is generated by interlocking of two monomers into a 2-fold symmetrical s

204 HIV-1-glycan shield to comprise a network of interlocking oligosaccharides, substantially ordered by

205 otaxanes consist of a tetra-amide macrocycle interlocked onto a polyether axle.

206 cally controlled solution-phase synthesis of interlocked organic cages with high stability.

207 a template-free one-pot synthesis of triply interlocked organic cages.

208 These interlocked organic molecules may prove useful as part o

209 A-DNA hybrid and is stabilized by the highly interlocked organization of protein subunits.

210 bon tetrachloride (-23.5 +/- 0.3 kJ mol(-1)) interlocks our study with Laurence's scale of H-bond bas

211 physics of shell growth, to explain how this interlocking pattern is created and regulated by mechani

212 of the particle, and a "quadruple-gear-like" interlocking pattern is observed.

213 er, we uncover the mechanistic basis for the interlocking pattern.

214 A template-free triply interlocked Pd6 cage (2) was synthesized by two-componen

215 The sole isolated interlocked photoproduct (Phi = 0.06) is a [2]rotaxane,

216 Together these interlocking pieces facilitated the identification of mo

217 t of stacking modules, like conventional toy interlocking plastic blocks, allowing for literally thou

218 lcite structure produced by the excretion of interlocking plates by the phytoplankton coccolithophore

219 The properties of mechanically interlocked polymeric systems depend not only on the pro

220 anically interlocked molecules, mechanically interlocked polymers are promising candidates for the cr

221 Analysis of mechanically interlocked polymers by ion mobility mass spectrometry p

222 Mechanically interlocked polymers can possess significant additional

223 f, primarily, the potential for mechanically interlocked polymers to act as dynamic (noncovalent) yet

224 The quest to construct mechanically interlocked polymers, which present precise monodisperse

225 thesis of high order main-chain mechanically interlocked polymers.

226 ulatory interactions, revealing a network of interlocked positive and negative feedback loops.

227 ol of different regulators so as to form two interlocked positive feedback circuits may enable S. mut

228 Dynamical modeling revealed interlocking positive feedback loop architecture, which

229 m expanding or contracting the cavity of the interlocked precursor.

230 menting the extrusion of the thread from the interlocked precursors.

231 ated by complex systems, generally involving interlocked regulatory feedback loops.

232 PLC is thus central to many important interlocking regulatory networks.

233 The kallikrein-kinin system, along with the interlocking renin-angiotensin system, is a key regulato

234 TlInTe2, with interlocked rigid and weakly bound substructures, exhibi

235 construction of molecular Hopf links (singly interlocked rings), the simplest type of catenane.

236 d acceptor components in at least one of the interlocked rings, thereby possessing unusual and unexpe

237 ealed a unique ring topology comprising four interlocking rings and positions the isoaspartate residu

238 the presence of an RNA-binding protein, two interlocking RNA coiled coils of double-stranded RNA, a

239 n which the linking ligands are mechanically interlocked rotaxane molecules is reviewed.

240 In addition, a permanently interlocked rotaxane was prepared by capping the end of

241 epresented as a two-dimensional pattern with interlocking S-shaped 12-chain motifs repeating regularl

242 Ceramic/polymer composite equipped with 3D interlocking skeleton (3D IL) is developed through a sim

243 The hetero[4]rotaxane contains an interlocked species in which a dibenzo[24]crown-8 ring t

244 benzylalkylammonium unit to form the second interlocked species.

245 Photooxygenation of permanently interlocked squaraine rotaxanes with anthracene-containi

246 A (Fe(II))(6)-coordinated triply interlocked ("Star of David") [2]catenane (6(1)(2) link)

247 catenane reveals a nearly perfect fit of the interlocked strands, and the ECD spectra show a signific

248 While no evidence of interlocked structure formation was observed following i

249 gnition to facilitate molecular motion in an interlocked structure is described.

250 ative synthesis process and the mechanically interlocked structure of the resulting catenane were est

251 axane supported the kinetic inertness of the interlocked structure, where the newly developed stopper

252 range crack energy dissipation enabled by 3D interlocking structure is considered as the primary rein

253 soft composites with a strong interface and interlocking structure.

254 to many fascinating molecules, ranging from interlocked structures to self-replicators.

255 ry brings together individual molecules into interlocked structures, where the assembly has one ident

256 les include the catenane, rotaxane, and knot interlocked structures.

257 system for the construction of higher order interlocked structures.

258 to support the formation of a wide range of interlocked structures.

259 hat the geometry of the olefinic axis of the interlocked struts determined the obtention of materials

260 EM, TJ were 30-52% shorter, fewer, and less interlocking, suggesting a weaker seal between endotheli

261 Mechanically interlocked supramolecular assemblies are appealing buil

262 We demonstrate this by creating interlocking sutures from biomimetic composites that sho

263 ack-electron transfer indicates that in this interlocked system, as in previously studied covalently

264 te-directed synthesis techniques to assemble interlocked systems in which the photo-redox components

265 f intricate and often beautiful higher order interlocked systems, including Solomon links, Borromean

266 with interpenetrating "zipper-like" aromatic interlocks that result in stiffness and robustness.

267 like hydrogen-bonding array to cooperatively interlock the ends of a foldamer together with its helic

268 ed under reduced conditions, to mechanically interlock the two components.

269 ding beta-hairpin of the alpha-COP CTD, thus interlocking the two proteins.

270 iver transplantation was the product of five interlocking themes.

271 provided an optimal geometry for mechanical interlocking, thereby achieving significant adhesion str

272 Utilizing elasticity originating from interlocked thermoelectric modules, stretchable 3D therm

273 The pseudo-meso non-interlocked thread does not afford significant selectivi

274 Unlike the non-interlocked thread, the rotaxane requires a catalyticall

275 rity, the dinuclear and trinuclear helicates interlock to form a [2]catenane and bis[2]catenane, bear

276 d X-ray crystallography confirmed the doubly interlocked topology, and subsequent demetalation afford

277 '(10), a nanoscale catenane composed of five interlocked toroids.

278 Circadian rhythms are generated by interlocked transcription-translation feedback loops tha

279 ed, revealing a stable molecular interaction interlocking transcription and translation.

280 the circadian clock consist of three or four interlocked transcriptional feedback loops [3, 4].

281 dian rhythms are generated by well-conserved interlocked transcriptional feedback loops in animals.

282 The molecular circadian clock is driven by interlocked transcriptional-translational feedback loops

283 The clock gene circuit in plants comprises interlocking transcriptional feedback loops, reviewed in

284 l-type specification is under the control of interlocking transcriptional feedback loops, with Wor1 b

285 wth and development in all organisms through interlocking transcriptional-translational feedback loop

286 1752 SUMMARY: The circadian system comprises interlocking transcriptional-translational feedback loop

287 that a thin calcareous layer (<=100 um) with interlocking units of radiating crystals (mammillae) and

288 and drunk driving laws, and alcohol ignition interlock use.

289 in the multi-scale cellular environment that interlocks various biochemical networks.

290 We focus on the evolution of company interlocks, whereby a company director simultaneously si

291 he sides of existing crystallites until they interlock with adjacent crystallites.

292 rrangement of DNA at the optimum spacing can interlock with multiple TLR9 like a zipper, leading to m

293 This design enabled the MNs to mechanically interlock with soft tissues by selective distal swelling

294 model features a cyclic [Au(I)-SR] pentamer interlocked with one staple trimer motif protecting the

295 These human adaptive cycles interlocked with plant and animal cycles.

296 orms a double negative feedback loop that is interlocked with the core feedback loop.

297 ch the macrocyclic polyether is mechanically interlocked with the cyclobis(paraquat-p-phenylene) (CBP

298 after 4 to 5 months but can be incompletely interlocked with the native bone.

299 biphasic microneedle array that mechanically interlocks with tissue through swellable microneedle tip

300 nonconvex rings with large internal cavities interlock within a 2D layered structure leading to the f