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1 detection of the assumed 1,3-cyclobutanediyl intermediate.
2 e site for the formation of a stable Cu-O(2) intermediate.
3 o CYP2B11-H1 while CYP2B11-H2 expression was intermediate.
4 h generates a deproteinated rcDNA (DP-rcDNA) intermediate.
5 elates with the stability of the RNH folding intermediate.
6 and Adamtsl2 indicating the necessity of an intermediate.
7 nt stem cells via a transient pre-alpha cell intermediate.
8 nformations for the longest-lived looped DNA intermediate.
9 s confirmed the involvement of a non-radical intermediate.
10 a hydrolytically labile covalent acyl-enzyme intermediate.
11 d characterization of this long hypothesized intermediate.
12 chemistry, and novel and unique biosynthetic intermediates.
13 y, transience, and low concentration of many intermediates.
14 in response to cholesterol and other sterol intermediates.
15 by toxic accumulation of lysine degradation intermediates.
16 rphyria disorders that accumulate toxic heme intermediates.
17 Torsin manipulation represents aberrant NPC intermediates.
18 pes of product accessible from this class of intermediates.
19 lar structure that is slowly formed from the intermediates.
20 ere conducted to identify relevant synthetic intermediates.
21 identification of stable two-helical folding intermediates.
22 iation, and probable structures of prefusion intermediates.
23 esults considering three groups: low (0-5%), intermediate (10-40%) and high (50-100%) pectin content.
24 ad) had 57% 2-week mortality; worse than the intermediate (17%) and high (25%) Ct tertiles and Xpert
25 and apo-ferredoxin (FDX2) are monitored, and intermediate [2Fe-2S] species, such as (FDX2:GLRX5:[2Fe-
26 ed by bacteremia duration: short (1-2 days), intermediate (3-6 days), and prolonged (>=7 days) and co
28 th hypertrophic cardiomyopathy and a low- or intermediate 5-year risk of sudden cardiac death underwe
30 xA revealed a previously undetected reaction intermediate, a carbinolamine product-reduced CTQ adduct
31 apsids assemble rapidly with minimal trapped intermediates, a realization of the Levinthal paradox.
32 ipoprotein) particles could act as efficient intermediate acceptors of cellular-derived UC, thereby p
33 ndirect information, they produce calls with intermediate acoustic features, suggesting a more generi
38 the increasing diversity among farms, but at intermediate aggregation levels (counties) it is possibl
41 ryptophan degradation, an unstable metabolic intermediate, alpha-amino-beta-carboxymuconate-epsilon-s
44 is both a central phospholipid biosynthetic intermediate and a multifunctional lipid second messenge
45 s appear to arise via a dicentric chromosome intermediate and breakage-fusion-bridge cycles that are
48 biochemical conversions because CO(2) is an intermediate and end-product of the digestion process an
50 BCG has remained the mainstay of therapy for intermediate and high-risk non-muscle-invasive bladder c
51 e find that hard sphere-like liquids have on intermediate and large scales a simple structural order
55 fect sites that promote adsorption of carbon intermediates and C-C coupling reactions while minimizin
56 of native MS in defining protein-associated intermediates and elucidating mechanistic details of enz
58 ptimal binding energies of important surface intermediates and to estimate the extent of potential ra
59 2%) were classified as high, 2058 (41.0%) as intermediate, and 2447 (48.8%) as low risk for bleeding.
61 include mean monocular uncorrected distance, intermediate, and near visual acuities (logarithm of the
62 Cu surface decreases the coverage of the *CO intermediate, and then this favors the protonation of *C
63 le in the lattices we predict early assembly intermediates, and indeed we observe such structures by
64 erization of authentic C-H functionalization intermediates, and not kinetically stabilized model comp
72 ties of 0.63, 0.43, and 0.33 for favorable-, intermediate-, and adverse-risk groups, respectively (P
73 (e.g. SNCA, PVALB) with the adjacent dorsal intermediate arcopallium (AId), an avian analog of mamma
74 tions two diastereomers of a borirane-borane intermediate are isolated, which upon further reduction
77 that electrostatic stabilizers of O(2)-bound intermediates are more crucial for cobalt porphyrin ORR
78 nal infrared spectroscopy data show that the intermediates are more fibrillar and deprotonated than t
79 h EPR is broadly applicable to trap reactive intermediates at low temperature and creates a new metho
81 these exonucleases results in an asymmetric intermediate, because Cas1-Cas2 protects the PAM sequenc
84 philic reagents to selectively capture these intermediates, both trisubstituted alpha,beta-unsaturate
85 nally tuning the thermodynamics of catalytic intermediates broadly and for understanding how copper a
86 red DNA substrates that stabilize a reaction intermediate by mimicking a "flipped-out" conformation o
87 -electron-oxidized diazatitanacyclohexadiene intermediates can be accessed via disproportionation of
88 that the dipyridyl structure stabilizes the intermediate carbanion, allowing the Michael adduct to b
90 type 1 diabetes included (i) an increase of 'intermediate cells' containing granules resembling those
92 elements and produce an atomic model of the intermediate, comprising 120 copies each of protein lamb
93 ts and kinetic constants provide glimpses of intermediate conformational states, time scales for moti
95 rd connectivity configuration represented an intermediate connectivity pattern compared to the preced
99 rotofilaments were mixtures of straight and "intermediate-curved" (100-300 nm diameter) in pH 7.5 sol
101 mycolic acid production and accumulation of intermediates derived from 3-oxo-mycolate precursors.
102 of boron catalyst for the activation of the intermediate dibenzyl ether and to identify the rate-det
103 .2%) to 56.1% (95% CI, 51.4%-60.7%) and with intermediate diets significantly increased from 23.2% (9
104 30, 2017, and had SIHD with angiographically intermediate disease (40% to 69% diameter stenosis on vi
105 s on the basis of pivotal trials of short or intermediate duration, often in narrowly defined pain po
106 rather than an alpha,beta-dehydro-amino acid intermediate during C(alpha)-thioether bridge LC-MS/MS f
107 al role in the generation of reactive oxygen intermediates during immunity and has been recently impl
108 e early recovery demonstrated characteristic intermediate dynamics distinguished by sustained high sp
110 ave been imaged, capturing the metastable or intermediate edge structures involved in the 2D ice grow
111 eport that the heterotypic nucleosome has an intermediate elasticity (8.5 +/- 0.5 MPa) compared to CE
112 Despite advances in the identification of intermediates, elucidating the catalytic mechanism of th
113 ly available on GitHub, targeting users with intermediate experience in bioinformatics and statistics
114 e isolated a paramagnetic bimetallic Ni(III) intermediate featuring a unique Ni(2)(OR)(2) (OR = alkox
117 ssing expression of crvA, a gene encoding an intermediate filament-like protein necessary for curvatu
119 - called desmogleins and desmocollins - link intermediate filaments (IFs) rather than actin to the pl
122 ough the formation of a covalent acyl-enzyme intermediate followed by deacylation via an activated wa
123 favors the protonation of *CO to *CHO, a key intermediate for methane generation, compared to the com
124 ubsequently showed Scleraxis was a potential intermediate for TGF-beta-regulated expression of Fibrom
125 The cyclic sulfamide products are suitable intermediates for the synthesis of chiral vicinal diamin
126 mma-cyanoesters that can be useful synthetic intermediates for the synthesis of diverse bioactive mol
127 Displacement loops (D-loops) are signature intermediates formed during homologous recombination.
129 Reactive alkoxy radicals are proposed as key intermediates, generated by direct homolytic activation
130 eactions of diazo compounds via free carbene intermediates have emerged as a practical, mild and powe
132 irus spread directly to humans or through an intermediate host is currently unclear, as is the potent
133 as transmitted to humans via an undetermined intermediate host, leading to infections in humans and o
134 implicating these animal species as possible intermediate hosts or animal models for 2019-nCoV infect
135 hrough a cascade mechanism involving several intermediates identified by mass spectrometric analysis.
136 cilitating TBA dehydration via a carbocation intermediate in an E1 mechanism; the calculations furthe
137 scle-invasive disease and was highest in GO, intermediate in PD, and lowest in R patients (P = 0.017)
138 to generate a highly reactive dihydropyrrole intermediate in situ followed by conjugate addition with
139 formation of the first oxaphosphetane (OPA) intermediate in such a domino reaction is examined withi
140 of phospholipid bilayer fragment as the key intermediate in the mechanism of liposome formation by m
141 report the formation of a previously unknown intermediate in the Mg-V-S compositional space, Mg(3)V(2
142 dels of the proposed cis-Fe(III)(OH)(halide) intermediate in the non-heme iron halogenases were synth
143 cove in forming and stabilizing the Ni(I)-CO intermediate in the Wood-Ljungdahl pathway of anaerobic
149 creates a new method to characterize elusive intermediates in multiple redox-centre containing protei
150 o of which adopt unique, likely off-pathway, intermediates in the canonical polymerization cycle.
153 ovel route to quantify dynamic processes and intermediates in the synthesis of silicon materials.
155 lesion with periodontal bone loss; Group I (intermediate) in which the border of the furcal lesion h
156 vation energies in the formation of carboxyl intermediate, in line with their higher activities and s
157 iple pathways for the generation of reactive intermediates, including mixed carboxylic acid-phosphori
158 nthesis showed that the coverage of reactive intermediates increased significantly when the Ru partic
159 photocatalytic efficiencies can improve when intermediate insulation layers are used to inhibit the c
162 es, formation of a covalent enzyme-adenylate intermediate is a common first step of all DNA ligases.
164 we found that population of the RNH folding intermediate is required to generate sufficient force to
166 hat the formation of highly reactive nitroso intermediates is essential for target inactivation in vi
168 from 14.8% to 18.5% among all patients with intermediate lesions, and from 44% to 75% among patients
169 followed by a decoding network through which intermediate-level sub-functions are combined in differe
170 both drug-sensitive and resistant strains at intermediate levels, a ubiquitous pattern seen in survei
172 ealed that the accumulation of glucosinolate intermediates limits phenylpropanoid production in a Med
173 igh resolution structures of purified stable intermediates, low resolution images of cell sections an
174 rationalized by the structure of the imidate intermediate, mainly influenced by the amine component.
177 rhamnosyltransferase that converts the final intermediate (MbA-R(2)) to complete the MbA molecule.
179 ons between PAH degradation network data and intermediate metabolite structures, gaining information
180 ifferentiate 3 profiles: healthy volunteers, intermediate mHLA-DR septic shock patients, and low mHLA
181 llular matrix structure, sugars, Krebs cycle intermediates, microbe-derived metabolites and altered m
185 ecular electron transfer (IET) to the native intermediate (NI), which only slowly decays to the resti
186 (E), an overlaying nidopallial stripe called intermediate nidopallium (NI), and the dorsally adjacent
187 scontinuation rates of tamoxifen among poor, intermediate, normal, and ultrarapid CYP2D6 metabolizers
188 f standard MRI sequences is that the ventral intermediate nucleus, dentatorubrothalamic tract, and ot
190 applied for the identification of bioactive intermediates of azithromycin (AZI) and ciprofloxacin (C
191 exhibited specific changes in the levels of intermediates of glycolysis/gluconeogenesis, the tricarb
192 s well as structures of covalent acyl-enzyme intermediates of PGA with canonical substrates (L-Asp an
193 ds to investigate light-induced processes in intermediates of sequential electron transfer chains.
194 rate ~10 times that of the leg; and released intermediates of the tricarboxylic acid cycle, balancing
197 w that the stabilized *HOCO and weakened *CO intermediates on PdH/NbN are critical to achieving highe
198 hown to be invariant to the stability of the intermediates or to the presence of additional misfolded
199 An additional Rh-H...C stabilization in some intermediates or transition states favors the hydrogen t
200 Metabolic dysfunction of the liver, as an intermediate organ for VD metabolism, contributes partly
201 ticipants enrolled in the SubPopulations and InteRmediate Outcome Measures In COPD (SPIROMICS) bronch
202 ontrol study of COPD: the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS),
203 ociated with greater likelihood of achieving intermediate outcomes, such as virologic suppression and
206 force tracing tasks at 1 Hz by pressing with intermediate phalanges; only one finger was instructed t
207 striatum: raclopride increased errors in the intermediate phase after DMS infusions, and increased er
208 signature targeting C>G is activated in the intermediate phase of disease progression in high-risk M
209 ion and morphogenesis are linked and whether intermediate pluripotent states exist remain controversi
210 ycytes give rise to parenchymal cells via an intermediate population of alpha-tanycytes with transien
211 urgery may provide better IOP control in the intermediate postoperative period and blunt the hyperten
212 prioritise evolutionary diversity, areas of intermediate precipitation that are found in the South A
214 for precision, in terms of repeatability and intermediate precision, did not exceed the maximum of 15
217 progenitors, raising the possibility that an intermediate progenitor state exists in the retina.
218 s, drives differentiation of RGs into apical intermediate progenitors, a more restricted progenitor t
219 nks DNA methylation to disease endpoints via intermediate proteomics phenotypes and identifies correl
225 iboswitches in multiple states, including an intermediate responsible for delayed terminator formatio
226 oting coordinative unsaturation in catalytic intermediates responsible for the heterolytic activation
227 n, 84% had clear cell histology, 53% were at intermediate risk of recurrence, and 47% were at high ri
228 this early feasibility study of the BEC for intermediate-risk PE, there were no deaths or device-rel
231 ion results in the formation of a non-native intermediate, separated by a significant free energy bar
234 alongside evidence that Zambia was a likely intermediate site along the routes of expansion of Bantu
235 d areas across southern Africa, we find that intermediate-sized herbivores (100-550 kg) switch activi
237 were dominated by the rare few that left at intermediate sizes and times, coinciding with managed fl
238 s has an important influence on the reaction intermediates' stability and, therefore, in the reaction
240 e-aware ancestral reconstructions reveals an intermediate stage that had already lost a large number
242 patients with NLPHL (early stages, n = 251; intermediate stages, n = 76; advanced stages, n = 144) w
243 initial bimolecular association to form the intermediate state can be mediated by many possible cont
244 Finally, the physiological relevance of the intermediate state KCNQ1 conductance is demonstrated usi
245 the channel: two closed state structures, an intermediate state, and an open state, each embedded in
246 re, we describe the native state, observable intermediate state, and unfolded state for ETR-3 RRM-3,
249 rated by Regulatory Networks) to explore the intermediate states of an EMT model network by computing
250 er conditions to maximize the populations of intermediate states, eliminating the guesswork of curren
252 be achieved if the changes in free energy of intermediate steps are minimized and the catalytic cycle
253 e 3D configuration of proteins and lipids at intermediate steps can only be resolved with cryo-electr
255 l spine synapses, keeping most of them at an intermediate strength level from which both long-term po
256 receptor 1 or GPR91) senses the citric cycle intermediate succinate and is implicated in various path
257 s and had increased levels of IL-6 signaling intermediates such as IL-6R and signal transducer and ac
260 bunit d, is added subsequently to form a key intermediate that accepts the two mitochondrially encode
261 o generate an electrophilic N-aryl nitrenoid intermediate that can engage in C-NAr bond formation to
262 , we demonstrate the presence of a misfolded intermediate that competes with productive folding.
263 n proceeds via a thiazolidine boronate (TzB) intermediate that results from fast (k(2) : ~5000 m(-1)
264 reduced intracellular succinate, a TCA cycle intermediate that serves as a direct electron donor to m
265 the sn-2 ester to form a cyclic tetrahedral intermediate that then collapses to produce lyso-lipopro
266 f substrates, NQO2 generates fairly unstable intermediates that reoxidize immediately back to the ori
267 ventionally understood as involving discrete intermediates that undergo an ordinary competition betwe
268 T and aminothiols, we resolved two transient intermediates, the thioimidate and the cyclic precursor
269 study provides novel insights into these key intermediates, their relevance for the catalytic cycle o
271 tocatalyst to oxidize an organopalladium(II) intermediate to high-valent Pd(III) or Pd(IV) intermedia
272 ocess where gp41 switches from a pre-hairpin intermediate to its post-fusion 6-helical bundle state.
273 ile RslO9 can further convert the rearranged intermediate to rishirilide D and lupinacidin A, an addi
275 electron transfer from the nitrogen radical intermediate to the Ir(IV) species in the catalytic cycl
276 ystem responding differentially to TCA cycle intermediates to regulate metabolism and key differentia
277 performance for identifying none-to-low vs. intermediate-to-high AD neuropathologic change (ADNC) wa
279 duced (adaptive) anxiety could be used as an intermediate translational model of pathological anxiety
280 phy, we detected an unexpected photochemical intermediate trapped in a crystal of the hIDO1-CO-Trp co
283 converted by CblC to a common cob(II)alamin intermediate via glutathione-dependent alkyltransferase
284 s included mean monocular distance-corrected intermediate visual acuity (DCIVA; 66 cm) and proportion
286 ly, the synthetic versatility of the CF(2)Br intermediates was showcased through functionalization to
289 To better understand the properties of these intermediates, we have prepared and characterized the fi
293 osette is therefore a reversible pluripotent intermediate whereby control over both pluripotency prog
294 copy (Cryo-EM) imaging reveals a crystalline intermediate wherein N-terminal nucleation domains exhib
295 actions of the key diazatitanacyclohexadiene intermediate, which can be accessed via multicomponent c
296 one-step construction of a spiroketal trimer intermediate, which can be selectively reduced to give t
297 ntermediate to high-valent Pd(III) or Pd(IV) intermediates, which promotes the formation of C-O bonds
298 s often fold via long-lived partially folded intermediates, whose structures, potentially toxic oligo
299 e each nascent betaOMP forms a hybrid-barrel intermediate with BAM/SAM in route to its biogenesis int