ライフサイエンスコーパス: intermediate filament

1 s comprised cytoskeletal proteins as well as intermediate filaments.

2 in addition to the upregulation of vimentin intermediate filaments.

3 on-membrane invested cellular organelles and intermediate filaments.

4 , as well as opposing effects from actin and intermediate filaments.

5 ents, microtubules, and cytokeratin 19-based intermediate filaments.

6 hilin B2, in the perinuclear organization of intermediate filaments.

7 the cytoskeleton: F-actin, microtubules, and intermediate filaments.

8 maintain their nucleus caged in a network of intermediate filaments.

9 dges as protrusions that integrate actin and intermediate filaments.

10 nserved across keratins and many non-keratin intermediate filaments.

11 linked with cleavage of vimentin and loss of intermediate filaments.

12 lterations, including accumulation of desmin intermediate filaments.

13 in fibers; instead, these fibers are keratin intermediate filaments.

14 ed by dynamic reorganization of keratin-rich intermediate filaments.

15 th a novel cytoplasmic reticular meshwork of intermediate filaments.

16 Two misregulated genes, intermediate filament-1 (if-1) and calamari (cali), were

17 he full suite and developmental interplay of intermediate filament alpha keratins and corneous beta-p

18 NF-DP), the medium NF subunit (NFM), and the intermediate filament alpha-internexin (INT) at P4.

19 s provide radically new insight into keratin intermediate filament and Aire function, along with a mo

20 FiVe1 targets the intermediate filament and mesenchymal marker vimentin (V

21 nd we studied F-actin fibres, Vimentin-based intermediate filaments and alpha-tubulin microtubules in

22 d the LINC complex, microtubules, actin, and intermediate filaments and assessed the consequences on

23 suggest that a balance of forces imposed by intermediate filaments and microtubules is required to m

24 r suppressor APC as a linker protein between intermediate filaments and microtubules.

25 Although causality between intermediate filaments and plasticity was not directly t

26 ance of cytoskeleton stabilisation proteins, intermediate filaments and proteins involved in posttran

27 cadherin adhesion complex containing keratin intermediate filaments and the catenin-family member pla

28 pairment due to defined genetic mutations of intermediate filaments and their regulators results in i

29 with a distinctive dual pattern to vimentin intermediate filaments and to membranes at leading edges

30 We found that K17 was released from intermediate filaments and translocated into the nucleus

31 Stresses perturbing intermediate-filament and cytoskeletal architecture indu

32 Desmin is an abundant muscle-specific intermediate filament, and disease mutations lead to its

33 GFAP is the major astrocytic intermediate filament, and in AxD patient brain tissue G

34 ll cytoskeleton is composed of microtubules, intermediate filaments, and actin that provide a rigid s

35 how that Dlg1 colocalizes with microtubules, intermediate filaments, and Golgi markers.

36 so associated with cytoplasmic giantin-based intermediate filaments, and such cells showed antiviral

37 Along with microtubules and microfilaments, intermediate filaments are a major component of the euka

38 However, intermediate filaments are emerging as major contributor

39 Intermediate filaments are major cytoskeletal components

40 reach high indentation depths, where desmin intermediate filaments are typically located.

41 Intermediate filaments are unique among cytoskeletal pol

42 ivity, actomyosin bundles, microtubules, and intermediate filaments, as well as the LINC complex, wer

43 Here we show that intermediate filaments assembled by keratins function as

44 Neurofilaments are intermediate filaments assembled from the subunits neuro

45 involvement of sacsin domains in regulating intermediate filament assembly and dynamics and identifi

46 sin, mutated in the ataxia ARSACS, regulates intermediate filament assembly and dynamics.

47 To characterize keratin intermediate filament assembly mechanisms at atomic reso

48 hannel of nuclear pores, the nexus points of intermediate filament assembly, and the locations of act

49 Furthermore, while microtubules and desmin intermediate filaments associate closely with cardiomyoc

50 est a detailed model for bundling of keratin intermediate filaments based on interfilament electrosta

51 septins accumulate at the wound margin, and intermediate filaments become polarized in the cells adj

52 that compares the developmental profiles of intermediate filaments between cats and humans.

53 nvelope protein that connects the nucleus to intermediate filaments by interacting with plectin.

54 relamin A, a component of the nuclear lamina intermediate filaments, by cleaving it at two sites.

55 ce transducer between cardiac desmosomes and intermediate filaments, cause an arrhythmogenic form of

56 In the absence of APC, intermediate filaments collapse and the cells are no lon

57 as an obligate subunit polymer for neuronal intermediate filaments comprising the neurofilament (NF)

58 ies and myopathies that are characterized by intermediate filament-containing inclusions.

59 ith both the parasite plasma membrane and an intermediate filament cytoskeleton called the inner-memb

60 formation of an alternative, stress-induced intermediate filament cytoskeleton has cardioprotective

61 The organization of the keratin intermediate filament cytoskeleton is closely linked to

62 However, FA cross-talk with the intermediate filament cytoskeleton is poorly understood.

63 mall heat shock proteins on the keratin 8/18 intermediate filament cytoskeleton using a well-controll

64 structure remains scarce, especially for the intermediate filament cytoskeleton.

65 ffect this value; however, the disruption of intermediate filaments decreased the persistence length.

66 Cs also presented in the cytoplasm increased intermediate filaments, dense bodies, and glycogen depos

67 ectories of microtubule segments in actin or intermediate filament-depleted cells, and observed a sig

68 lase, and the concurrent accumulation of the intermediate filament desmin in the myofibers of the pat

69 Desmin intermediate filaments (DIFs) form an intricate meshwork

70 Here we show that keratin intermediate filaments directly regulate the morphogenes

71 potentially by promoting the degradation of intermediate filaments driving EMT, resulting in cell de

72 achinery; however, the role of the desmosome-intermediate filament (DSM-IF) network is poorly underst

73 y that is implicated in crosslinking keratin intermediate filaments during hair formation, yet these

74 We studied two aspects of vimentin intermediate filament dynamics-transport of filaments an

75 g cords of cells, where they extend vimentin intermediate filament-enriched protrusions into the 3D E

76 sing long-term 4D imaging, that the vimentin intermediate filament establishes mitotic polarity in ma

77 Nestin is an atypical intermediate filament expressed strongly in neural proge

78 Vimentin intermediate filament expression is a hallmark of epithe

79 found alterations in endotube structure and intermediate filament expression upon infection with nem

80 0, Hsp70, Hsp90, and Hsp110 were measured in intermediate filament extracts prepared after a 3-h expo

81 for the vimentin (VIM) gene, a member of the intermediate filament family involved in cell and tissue

82 Keratin intermediate filaments form dynamic intracellular networ

83 In cells, keratin intermediate filaments form networks of bundles that are

84 Nestin, an intermediate filament found in neural progenitor cells d

85 Reversion of the keratin intermediate filament fragility phenotype associated wit

86 nnot form filaments by itself in cytoplasmic intermediate filament-free SW13 cells.

87 distinct steps, expand our understanding of intermediate filament functions, and identify microridge

88 Expression levels of glial intermediate filaments (GFAP, vimentin) and extracellula

89 Mutations in the astrocyte-specific intermediate filament glial fibrillary acidic protein (G

90 by increased cytoplasmic accumulation of the intermediate filament glial fibrillary acidic protein (G

91 Actomyosin stress fibres, microtubules and intermediate filaments have distinct and complementary r

92 The presence of actin, tubulin, and intermediate filament homologs in these relatively simpl

93 ic screen for defects in the organization of intermediate filaments identified a mutation in the cata

94 ongated, GFAP-positive spindle cells (due to intermediate filaments identified ultrastructurally) wit

95 Intermediate filament (IF) attachment to intercellular j

96 Intermediate filament (IF) cytoskeletal networks simulta

97 The intermediate filament (IF) cytoskeleton has been propose

98 Glial fibrillary acidic protein (GFAP) is an intermediate filament (IF) III protein uniquely found in

99 (K5) or keratin 14 (K14) genes, encoding the intermediate filament (IF) network of basal epidermal ke

100 of NMJs by linking them to the postsynaptic intermediate filament (IF) network.

101 entified nine protein families with putative intermediate filament (IF) properties.

102 dominant mutations in the gene encoding the intermediate filament (IF) protein GFAP.

103 s since the complete primary sequence of the intermediate filament (IF) protein vimentin was reported

104 Vimentin, a type III intermediate filament (IF) protein, is phosphorylated pr

105 is associated with the overexpression of the intermediate filament (IF) proteins desmin and vimentin

106 gigaxonin, an E3 ligase adapter that targets intermediate filament (IF) proteins for degradation in n

107 the molecular and the nano-scale, including intermediate filament (IF) proteins from the cell cytosk

108 in keratin 14 (K14) or K5, the type I and II intermediate filament (IF) proteins that copolymerize to

109 Intermediate filament (IF) proteins, including nuclear l

110 alpha-Internexin is one of the neuronal intermediate filament (IF) proteins, which also include

111 ns are important functional determinants for intermediate filament (IF) proteins.

112 mains that anchor a three-dimensional desmin intermediate filament (IF) web.

113 Intermediate filament (IF)-like cytoskeleton emerges as

114 Intermediate filaments (IF) are major constituents of th

115 ortex suggests that the alpha-keratin- based intermediate filaments (IFs) align with the hair's axis,

116 amily proteins associate with the network of intermediate filaments (IFs) and affect its reorganizati

117 inds to both microtubules (MTs) and vimentin intermediate filaments (IFs) and stabilizes MTs.

118 Intermediate filaments (IFs) are a component of the cyto

119 Actin filaments, microtubules, and intermediate filaments (IFs) are central elements of the

120 Intermediate filaments (IFs) are components of the cytos

121 Intermediate filaments (IFs) are composed of one or more

122 Intermediate filaments (IFs) are cytoskeletal polymers t

123 The type III intermediate filaments (IFs) are essential cytoskeletal

124 Intermediate filaments (IFs) are key players in the cont

125 Intermediate filaments (IFs) are key to the mechanical s

126 Vimentin intermediate filaments (IFs) are part of a family of pro

127 Keratin intermediate filaments (IFs) are the major cytoskeletal

128 Intermediate filaments (IFs) form a dense and dynamic ne

129 Keratin intermediate filaments (IFs) form cross-linked arrays to

130 tin filaments, little is known about whether intermediate filaments (IFs) have an influence on MT dyn

131 Intermediate filaments (IFs) in cardiomyocytes consist p

132 e of structural support fulfilled by keratin intermediate filaments (IFs) in surface epithelia likely

133 The abundance and diversity of intermediate filaments (IFs) in the C. elegans intestine

134 - called desmogleins and desmocollins - link intermediate filaments (IFs) rather than actin to the pl

135 In GAN, aggregates of intermediate filaments (IFs) represent the main patholog

136 cations behave as effective cross-linkers of intermediate filaments (IFs) such as vimentin IF (VIF).

137 n of the third major cytoskeletal component, intermediate filaments (IFs).

138 filaments (F-actin), microtubules (MT), and intermediate filaments (IFs).

139 groups show: (i) thicker fibers of vimentin intermediate filaments, (ii) clusters of integrin alpha(

140 We propose that the length of intermediate filaments in cells is regulated by the oppo

141 Desmoplakin (DP) serves to anchor intermediate filaments in desmosomal complexes.

142 gulation, and identify an early function for intermediate filaments in development.

143 t loss of sacsin effects the organization of intermediate filaments in multiple cell types, which imp

144 J area, reduces the abnormal accumulation of intermediate filaments in nerve terminals of the neuromu

145 embly, organization, and dynamics of keratin intermediate filaments in skin keratinocytes.

146 organization, and dynamics of K14-containing intermediate filaments in skin keratinocytes.

147 The enrichment of intermediate filaments in the apical cytoplasm of intest

148 nerate force, but the precise involvement of intermediate filaments in these processes remains unclea

149 s of cytoskeletal networks, but the roles of intermediate filaments in this process are poorly unders

150 (dynamic cytoskeletal structures and static intermediate filaments) in that it uses ATP hydrolysis t

151 nvestigated the role of vimentin, a type III intermediate filament, in this process using three well-

152 In both species, levels of intermediate filaments increased considerably throughout

153 In striated muscle, desmin intermediate filaments interlink the contractile myofibr

154 ical integrity in the mesendoderm by keratin intermediate filaments is required to balance stresses w

155 a balance of dynamic microtubules and desmin intermediate filaments is required to maintain nuclear s

156 cking of the bacterium specifically requires intermediate filaments, is a process distinct from pore

157 The type I intermediate filament keratin 16 (KRT16 gene; K16 protei

158 High levels of the intermediate filament keratin 17 (K17) correlate with a

159 Vimentin and the intestinal epithelial intermediate filament keratin 18 interact with the C-ter

160 We reported that the intermediate filament keratin 6a (K6a) is constitutively

161 Here, we demonstrate that the intermediate filament keratin-19 (Krt19) marks long-live

162 Keratin intermediate filaments (KIFs) protect the epidermis agai

163 ssing expression of crvA, a gene encoding an intermediate filament-like protein necessary for curvatu

164 of the nuclear lamina, a dynamic meshwork of intermediate filaments lining the nuclear envelope inner

165 myosin contractility with the nucleoskeleton-intermediate filament linker protein nesprin-3 pulled th

166 Its intestinal intermediate filaments localize exclusively to the endot

167 d cells in a novel cytoplasmic giantin-based intermediate filament meshwork and in cytoplasmic bodies

168 Furthermore, stress fibres and intermediate filaments modulate the mechanical propertie

169 To investigate if loss of sacsin affects intermediate filaments more generally, the distribution

170 1 caused partial collapse of the cytoplasmic intermediate filament network and mislocalized to the nu

171 ggregates and redistribution of the vimentin intermediate filament network and retrograde motor prote

172 d that plectin deficiency leads to increased intermediate filament network and sarcomere dynamics, ma

173 jor protective role of a properly configured intermediate filament network as an intracellular barrie

174 s on the integrity of the nuclear lamina, an intermediate filament network associated with the linker

175 nduce spatial reorganization of the vimentin intermediate filament network in cells.

176 The mechanical resilience of the keratin intermediate filament network itself is determined by fi

177 are phosphoglycoproteins and form the major intermediate filament network of simple epithelia.

178 ced intestinal tube stability due to altered intermediate filament network phosphorylation.

179 ur results indicate that a flexible vimentin intermediate filament network promotes LBBM of amoeboid

180 esions induces reorganization of the keratin intermediate filament network toward these stressed site

181 HDAC6-induced reorganization of the vimentin intermediate filament network.

182 These effects extend to the microtubule and intermediate filament networks as well as the nucleus, a

183 ent light chain variants results in abnormal intermediate filament networks associated with defects i

184 to maintain the integrity of desmosomes and intermediate filament networks in vitro and in vivo.

185 lecular motor activity, we conclude that the intermediate filament networks maintain nuclear mechanic

186 e modulated by structural changes in keratin intermediate filament networks.

187 ty properties of the lamin polymer and other intermediate filament networks.

188 alpha-Internexin is a member of the neuronal intermediate filament (nIF) protein family, which also i

189 ibrillary acidic protein (GFAP) is the major intermediate filament of mature astrocytes in the mammal

190 n of the interaction between alpha6beta4 and intermediate filaments or laminin-332 results in similar

191 provides an excellent model system to study intermediate filament organization and function in vivo.

192 mutant form of the gene encoding for desmin intermediate filaments, p.D399Y.

193 that vimentin, a protein comprising type III intermediate filament, participates in such cross-talk f

194 odel null for the gene encoding the type III intermediate filament peripherin (Prph).

195 The physiological significance of intermediate filament phosphorylation during mitosis for

196 Increased intermediate filament phosphorylation was detected by tw

197 ing the first credible evidence that keratin intermediate filaments play a unique and essential role

198 The results suggest that an intermediate filament protein acts in a novel pathway to

199 Importantly, dL5 fusions to an intermediate filament protein CreS are significantly les

200 Lamin A is a nuclear intermediate filament protein critical for nuclear archi

201 In particular, lamin A/C, an intermediate filament protein critical for the interphas

202 ain subpopulations of cells that express the intermediate filament protein cytokeratin 5 (CK5).

203 The intermediate filament protein desmin is encoded by the g

204 ticular, we show that S-nitrosylation of the intermediate filament protein desmin is significantly in

205 is unknown.SIGNIFICANCE STATEMENT Nestin, an intermediate filament protein highly expressed in neural

206 Peripherin, a neuronal intermediate filament protein implicated in neurodegener

207 The intermediate filament protein keratin 14 (K14) provides

208 Expression of the intermediate filament protein keratin 17 (K17) is robust

209 The intermediate filament protein keratin 17 (Krt17) shows h

210 The intermediate filament protein keratin 8 (K8) and its cro

211 of the nuclear membrane is enriched with the intermediate filament protein lamin A.

212 We also have determined that the intermediate filament protein nestin correlates with tum

213 The intermediate filament protein Nestin labels populations

214 The intermediate filament protein Nestin serves as a biomark

215 pinal fluid that is specific for a cytosolic intermediate filament protein of astrocytes.

216 Aberrant induction of expression of the intermediate filament protein peripherin, which is assoc

217 e Abs directed against the neuronal type III intermediate filament protein peripherin.

218 The intermediate filament protein synemin is present in astr

219 Taken together, Nes-S is a new neuronal intermediate filament protein that exerts a cytoprotecti

220 GFAP is an intermediate filament protein that is expressed predomin

221 ften initiate the expression of vimentin, an intermediate filament protein that polymerizes into netw

222 ive slime of hagfishes contains thousands of intermediate filament protein threads that are manufactu

223 iotin-labeled artemisinin, we identified the intermediate filament protein vimentin as an artemisinin

224 se to perform superresolution imaging of the intermediate filament protein vimentin by stimulated emi

225 The intermediate filament protein vimentin is involved in th

226 tor for activated C kinase 1 (RACK1) and the intermediate filament protein vimentin that correlated w

227 The intermediate filament protein vimentin, which has been p

228 Focusing on the intermediate filament protein vimentin, which is frequen

229 es not recognize Rac1 but rather detects the intermediate filament protein vimentin.

230 Vimentin is an intermediate filament protein whose expression correlate

231 Keratin 9 (K9) is a type I intermediate filament protein whose expression is confin

232 Nestin, an intermediate filament protein widely used as a marker of

233 s in GFAP, which encodes the major astrocyte intermediate filament protein, glial fibrillary acidic p

234 Vimentin, an abundant intermediate filament protein, presumably has an importa

235 d that vimentin, a leucine zipper-containing intermediate filament protein, suppresses ATF4-dependent

236 invasiveness by directly phosphorylating an intermediate filament protein, vimentin, thereby inhibit

237 The intermediate filament protein, vimentin, was upregulated

238 patterns and function of internexin neuronal intermediate filament protein-alpha a (inaa), the encodi

239 is the gene that encodes the major astrocyte intermediate filament protein.

240 bules and microfilaments, but its effects on intermediate filament proteins (IFs) are unknown.

241 at betaH-spectrin regulates the placement of intermediate filament proteins forming a terminal web ar

242 Simple-type epithelial keratins are intermediate filament proteins important for mechanical

243 In contrast, the roles of intermediate filament proteins in this process are poorl

244 eriplakin (PPL), interacts specifically with intermediate filament proteins K8, K18, and vimentin via

245 ility of the nucleus comes from meshworks of intermediate filament proteins known as lamins forming t

246 in the LMNA gene, which encodes the nuclear intermediate filament proteins lamin A and C, two major

247 in keratin 8 (K8) and keratin 18 (K18), the intermediate filament proteins of hepatocytes, predispos

248 Keratins are cytoplasmic intermediate filament proteins providing crucial structu

249 We deleted the genes encoding two intermediate filament proteins required for astrocyte ac

250 It is composed mainly of lamins, which are intermediate filament proteins that assemble into a fila

251 Lamins are intermediate filament proteins that assemble into a mesh

252 Lamins are intermediate filament proteins that form a scaffold, ter

253 Keratin 8 (K8) and keratin 18 (K18) are the intermediate filament proteins whose phosphorylation/tra

254 onnexins, growth factors, membrane proteins, intermediate filament proteins, and chaperones.

255 ed its interactions with 14-3-3 and vimentin intermediate filament proteins, and vimentin depletion i

256 Lamins, the type V nuclear intermediate filament proteins, are reported to function

257 nd keratin 18 (K18), two epithelial-specific intermediate filament proteins.

258 vement of the auxiliary beta subunit through intermediate filament proteins.

259 (K8/18) are simple epithelial cell-specific intermediate filament proteins.

260 Keratins 8 and 18 (K8/K18) are the intermediate filaments proteins of simple-type digestive

261 PC1 proteins included keratin intermediate filaments; proteins associated with inflamm

262 suggests that the mammalian cytoskeleton and intermediate filaments provide the physical scaffold for

263 hoA knockout in fibroblasts induced vimentin intermediate filament reorganization, accompanied by red

264 d PV IgG-triggered dsg3 endocytosis, keratin intermediate filament retraction, and loss of cell-cell

265 which are endowed with a particularly dense intermediate filament-rich layer that is referred to as

266 The latter slot intermediate filament rods into basic PRD domain grooves

267 rms interact with plasma membranes, vimentin intermediate filaments, SH3-containing class I myosins,

268 This intermediate filament subtype switching induced dysregul

269 Nestin, unlike other intermediate filament subtypes, regulates cdk5 kinase by

270 wide hypocellular layer formed by bundles of intermediate filaments surrounded the central canal both

271 ith both its integration into the endogenous intermediate filament system and segregation into protei

272 determined the precise role of the vimentin intermediate filament system in regulating the migration

273 cardiomyocytes of the extrasarcomeric desmin intermediate filament system is frequently observed.

274 ng link between the nuclear envelope and the intermediate filament system seems to be dispensable for

275 ccompanied by a loss of DSG2, changes of the intermediate filament system, and increased phosphorylat

276 The nuclear lamina-a meshwork of intermediate filaments termed lamins-is primarily respon

277 ation of MTs facilitates an interaction with intermediate filaments that complex with the sarcomere,

278 Lamins are intermediate filaments that line the inner nuclear membr

279 Lamins A and C are intermediate filaments that provide structural support t

280 les create diverse cellular protrusions, but intermediate filaments, the strongest and most stable cy

281 plakin repeat domain (PRD) which recognizes intermediate filaments through an unresolved mechanism.

282 Vimentin is one of the first cytoplasmic intermediate filaments to be expressed in mammalian cell

283 tabilizes a complex of solubilized actin and intermediate filaments to maintain a pool of "bioavailab

284 lectin is a prototypical plakin that tethers intermediate filaments to membrane-associated complexes.

285 f keratin filaments: a unified mechanism for intermediate filament transport.

286 Because FA maturation involves the vimentin intermediate filament (vIF) network, we also examined th

287 we unveil the critical function of vimentin intermediate filaments (VIFs) in maintaining the structu

288 However, the role of vimentin intermediate filaments (VIFs) in regulating nuclear shap

289 he association of mitochondria with vimentin intermediate filaments (VIFs) measurably increases their

290 rs of cortex architecture and identified the intermediate filament vimentin and the actin-vimentin li

291 Previously, we identified the intermediate filament vimentin as an extracellular membr

292 n a genome-wide selection, we identified the intermediate filament vimentin as required for infection

293 stasis and describe a novel function for the intermediate filament vimentin in proteostasis as a spat

294 The intermediate filament vimentin is required for cells to

295 e 9H4, revealed its ability to recognize the intermediate filament vimentin.

296 Consistent with its role as an intermediate filament, vimentin acted as a scaffold to r

297 Specifically, intermediate filaments were highly expressed in extra-em

298 We focus here on desmin, a type III intermediate filament, which is specifically expressed i

299 hallenges for studies of the neurobiology of intermediate filaments with specific attention to identi

300 We examined levels of these intermediate filaments within cat and human primary visu