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1 n this process, as indicated by its distinct intermediate phenotype.
2 dies may be an especially promising class of intermediate phenotype.
3 henotype but not with the tremor-dominant or intermediate phenotype.
4 as the FasL-defective gld mouse displayed an intermediate phenotype.
5 ssortants R(T(VP3)) and T(R(VP3)) induced an intermediate phenotype.
6 erminal portion of EphB2 is truncated had an intermediate phenotype.
7 iously reported, and WeeB cells displayed an intermediate phenotype.
8 of CCR2(+) cells, whereas memTNF mice had an intermediate phenotype.
9 Heterozygotes showed an intermediate phenotype.
10 ytotoxicity, while class 2 mutations have an intermediate phenotype.
11 rs (NA5A14, NA4A19, and NA4A23) exhibited an intermediate phenotype.
12 Mice lacking p50 alone displayed an intermediate phenotype.
13 rozygous for PAR-2 gene disruption showed an intermediate phenotype.
14 rly abrogated; the palm(-) eNOS exhibited an intermediate phenotype.
15 and cells from obligate heterozygotes had an intermediate phenotype.
16 2, that has reduced Snail function showed an intermediate phenotype.
17 e GM2 activator deficiency that manifests an intermediate phenotype.
18 and mice with medium expression displayed an intermediate phenotype.
19 ected with UV-inactivated virus displayed an intermediate phenotype.
20 ypes more recently derived from an ancestral intermediate phenotype.
21 e adversity is a highly promising depressive intermediate phenotype.
22 d-S16E-PLB-transduced hES2-vCMs displayed an intermediate phenotype.
23 tisense oligonucleotides to SMA mice with an intermediate phenotype.
24 n whom somatic mosaicism was associated with intermediate phenotypes.
25 dies that might lead to the discovery of new intermediate phenotypes.
26 tal muscular dystrophy, Bethlem myopathy and intermediate phenotypes.
27 rlying mechanism of schizophrenia-associated intermediate phenotypes.
28 Black Swiss mice, showed in most parameters intermediate phenotypes.
29 as assayed via specific hippocampus-related intermediate phenotypes.
30 are usually measured by multiple correlated intermediate phenotypes.
31 wed by the F61L and F61W variants, which had intermediate phenotypes.
32 ween them followed by the elimination of all intermediate phenotypes.
33 rs involved in synaptic function and related intermediate phenotypes.
34 ing neo- and established tetraploids exhibit intermediate phenotypes.
35 rly transient and late-onset colonization as intermediate phenotypes.
36 everity, ranging from infantile lethality to intermediate phenotypes.
37 sessment of the potential role of particular intermediate phenotypes.
40 cognitive control, may represent a promising intermediate phenotype across major depressive disorder
41 SNIP) was formed to examine a broad array of intermediate phenotypes across psychotic disorders and t
42 and arousal thresholds that could represent intermediate phenotypes affecting the expression of slee
43 that observed in male mice and discovered an intermediate phenotype after neutering of either sex.
46 ing strains and a rheostatic distribution of intermediate phenotypes among the others (Tukey-Kramer h
48 n, the clonal spread of penicillin-resistant/intermediate phenotypes and a novel introduction of the
50 tegy for examining both the genetic basis of intermediate phenotypes and functional testing of candid
51 iple testing and study design, definition of intermediate phenotypes and interaction between polymorp
52 ng selection-in which fitness is highest for intermediate phenotypes and lowest for the extremes-has
53 s are disease phenotypes caused by different intermediate phenotypes and pathways and thereby are pot
54 2 subjects with STAT3 somatic mosaicism had intermediate phenotypes and were found to have preserved
56 mportance of testing links between genotype, intermediate phenotype, and clinical outcome in the same
58 mental modifiers; evaluate disease subtypes, intermediate phenotypes, and biomarkers; and investigate
59 tion, to characterize their association with intermediate phenotypes, and to investigate their role i
60 autoimmune ovarian dysgenesis (AOD) and its intermediate phenotypes, antiovarian autoantibody respon
63 ally important for metabolites because these intermediate phenotypes are closer to the underlying pat
64 ll as other recent results, we conclude that intermediate phenotypes are likely to be most valuable i
69 ated evolution across the fishes, records of intermediate phenotypes are vanishingly rare, with only
71 ly informative target for genetic studies of intermediate phenotypes as their genetic underpinnings m
73 sion, protein-protein interaction, and brain intermediate phenotype association analysis to identify
74 dy from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) consortium 1) compares
75 rs from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) consortium were studied
76 ) from the Bipolar-Schizophrenia Network for Intermediate Phenotypes (B-SNIP) consortium, 18-65 years
78 me of what Bipolar-Schizophrenia Network for Intermediate Phenotypes (B-SNIP) has learned so far to g
84 sponse to PA (how one feels during PA) as an intermediate phenotype between genetic variation and PA
85 Rac1(flox/flox); Rac3(+/-); Cre mice showed intermediate phenotype between Rac1(flox/flox); Cre and
87 tant was bigger than pgk3.2 and displayed an intermediate phenotype between the two single mutants in
88 healed (sham) laparotomy group expressed an intermediate phenotype between the uninjured and hernia
90 tested, the TUBA1A-V409I mutant exhibits an intermediate phenotype between wild type and the more se
91 gainst venous thromboembolism and display an intermediate phenotype between wild-type and F12-null an
93 pocampal and amygdalar volumes (potential CD intermediate phenotypes) between heavy cannabis users an
95 atory network, circRNA expression is also an intermediate phenotype bridging genetic variation and ph
96 polarized murine T cell subtypes, as well as intermediate phenotypes, by their native DNA 5mCpG patte
97 ults show how detailed genetic studies of an intermediate phenotype can elucidate mechanisms that may
98 , combined with careful modeling of distinct intermediate phenotypes, can provide insights into the g
102 ic disorders and to test the hypothesis that intermediate phenotype characteristics are homogeneous w
103 ficient BALB/c mice, however, demonstrate an intermediate phenotype characterized by chronic lesions
104 strophy types Bethlem and Ullrich as well as intermediate phenotypes characterized by muscle weakness
105 on of phenotypic heterogeneity, quantitative intermediate phenotypes characterizing basal glucose hom
108 rnation between the two cell types expressed intermediate phenotypes consistent with dual adaptation
109 , double mutants of arf-1.1 and ncs-1 had an intermediate phenotype, consistent with NCS-1 and ARF-1.
110 by the Bipolar and Schizophrenia Network for Intermediate Phenotypes consortium included 326 probands
111 ta from the Bipolar-Schizophrenia Network on Intermediate Phenotypes consortium, we examined VC struc
112 ce Test, the use of impaired attention as an intermediate phenotype could increase the power of genet
115 chiatry has been particularly enamoured with intermediate phenotypes, due to uncertainty about diseas
116 ps of individuals with differential risk for intermediate phenotypes (eg, lipid levels, fasting insul
117 rewards, has been implicated as a potential intermediate phenotype (endophenotype) for addictive dis
118 polyploid morphological divergence from the intermediate phenotype expected (based on progenitor mor
119 mbling a limb girdle muscular dystrophy, and intermediate phenotypes falling between UCMD and Bethlem
122 This renders brain rhythms an interesting intermediate phenotype for cognitive and behavioral trai
124 measures and suggests that DD is a promising intermediate phenotype for genetic dissection of impulsi
127 t the usefulness of cortical thickness as an intermediate phenotype for neuropsychiatric diseases.
128 al and hippocampal activation as a promising intermediate phenotype for psychiatric disease and sugge
129 ain systems-level abnormality is a potential intermediate phenotype for psychiatric disorder, we stud
130 n to reward expectancy is a well-established intermediate phenotype for psychiatric disorders, specif
133 sensory responsivity represent an important intermediate phenotype for research, screening, and supp
138 or C-terminal truncation allele resulted in intermediate phenotypes for DSB formation, recombination
139 RISPR/Cas9 to generate an allelic series and intermediate phenotypes for functional analysis of candi
140 nfluences anxiety in mice is associated with intermediate phenotypes for human anxiety disorders acro
141 rventions and for identification of suitable intermediate phenotypes for molecular genetic investigat
144 source of potentially useful endophenotypes (intermediate phenotypes) for psychiatric genetics, as th
145 ciations between complex traits and relevant intermediate phenotypes, has therefore remained challeng
146 en discovered and cell transition states and intermediate phenotypes have been characterized across d
151 integrated into imaging genetics to provide intermediate phenotypes (i.e. endophenotypes) that bridg
152 henotypic representations, serving as robust intermediate phenotypes (i.e., endophenotypes), presumab
154 ble at Irgb10 and resistant at Iigp2, had an intermediate phenotype implicating the nonredundant role
157 tability of impaired attention for use as an intermediate phenotype in genetic studies, the authors e
158 er severity grade in PLTP-deficient mice, an intermediate phenotype in PLTP-deficient heterozygotes,
159 ckle trait whole blood clots demonstrated an intermediate phenotype in response to tissue plasminogen
161 l2), and of 791delG to determine whether the intermediate phenotype in the 791delG heterozygous state
164 n maturation, these cells give rise to a new intermediate phenotype in which intracellular class II m
165 ects of the HLA-DRB1 locus on asthma and its intermediate phenotypes in Aboriginal people from the Ki
167 ocus offer a unique opportunity to study the intermediate phenotypes in carriers at high risk for aut
169 risk and heritability estimates, serving as intermediate phenotypes in future genetic studies for ex
170 frontal and temporoparietal P300 changes as intermediate phenotypes in genetic studies of schizophre
171 uggesting that these measures could serve as intermediate phenotypes in genetic studies of schizophre
172 ne expression levels considered as tractable intermediate phenotypes in mapping complex diseases.
173 This analysis illustrates the value of such intermediate phenotypes in mapping susceptibility loci f
176 vel the role of potentially high-dimensional intermediate phenotypes in the relationship between envi
177 rozygous for the Msh2 deficiency display an "intermediate" phenotype in these regards, suggesting tha
178 II (DeltaII; bases 7692 to 7705) produced an intermediate phenotype, in that replicons had marginal R
179 Larvae with mosaic expression of bix have intermediate phenotypes, in which a partial notochord is
181 9, has been associated with CD diagnosis and intermediate phenotypes, including abstinence-induced wi
183 rer mice with thin myelin sheaths display an intermediate phenotype indicating that CNS neurons are s
189 , the identification and characterization of intermediate phenotypes is substantially more difficult
190 Genome-wide association studies (GWAS) with intermediate phenotypes, like changes in metabolite and
191 Understanding how genetic variation affects intermediate phenotypes, like DNA methylation or gene ex
192 biological mechanisms of a well established intermediate phenotype linked to schizophrenia, and unde
193 al-GlcNAc-Gal-Glc-HepI) structures displayed intermediate phenotypes (<50% killing with 2 mug/ml and
195 ions due to poor extinction recall may be an intermediate phenotype mediating the effects of genetic
196 cate this finding and establish the biologic intermediate phenotypes mediating this relationship.
197 ess microbial activity and can be used as an intermediate phenotype monitoring the host-microbiome re
199 ions are semidominant: heterozygotes have an intermediate phenotype most readily identified by palmar
201 1 sequence variants than VL, reflecting the 'intermediate phenotype' nature of viral variation; (2) a
202 ned both p53 alleles (MMTV-myc/p53(+/+)); an intermediate phenotype occurred in mice with a single in
207 istamine sensitization (Bphs) is a monogenic intermediate phenotype of EAE controlled by histamine H(
216 to further analyses in healthy Europeans for intermediate phenotypes of BD, including hippocampal vol
218 an fMRI based episodic memory task, we found intermediate phenotypes of mental disorders in human car
219 s of EAE susceptibility and severity and the intermediate phenotypes of mononuclear cell infiltration
220 ent hippocampal vacuolization and many other intermediate phenotypes of schizophrenia in Sp4 hypomorp
221 ed multiple co-methylation modules linked to intermediate phenotypes of WS, with the top-scoring modu
223 tivity, so that heterozygote mutants show an intermediate phenotype on cell fate and cell death.
224 monary disease study and five GWA studies of intermediate phenotypes, one each on serum immunoglobuli
225 sing on family-based studies of quantitative intermediate phenotypes or endophenotypes, in tandem wit
227 vival was not explained by selection against intermediate phenotypes or negative interactions among p
228 The genetic study of behavioral and biologic intermediate phenotypes (or 'endophenotypes') indexing a
229 neuronal cells, and (3) a cell type with an intermediate phenotype, possibly representing radial gli
233 independent samples and association with an intermediate phenotype provides strong support for TLR10
234 e polymorphism in ZNF804A suggests that this intermediate phenotype proxies a distinct neural system
235 bility for SCZ and BD could help to discover intermediate phenotypes, quantifiable biological traits
236 PTX reflects the genetic control of distinct intermediate phenotypes rather than allelic variation in
238 ngs also provide convergent evidence that an intermediate phenotype related to prefrontal cortical fu
239 results identify a potential dynamic network intermediate phenotype related to the genetic liability
241 these polymorphisms on body composition and intermediate phenotypes related to obesity was examined
242 Expression of a mutant p53 gene yielded an intermediate phenotype relative to HPV-16 E6, generating
243 itudinal trajectories of adiposity and other intermediate phenotypes relevant to mental health during
246 ke, obesity, and insulin resistance, with an intermediate phenotype seen in heterozygous null mice on
247 pproach of examining SNPs associated with an intermediate phenotype should be considered as a method
250 ta from the Bipolar-Schizophrenia Network on Intermediate Phenotypes studies 1 and 2 across 6 sites.
252 e biological origins of heterogeneity of key intermediate phenotypes such as cognition and emotion ca
255 n be derived using genetic associations with intermediate phenotypes such as subcomponents of auditor
256 Furthermore, some silencing mutants with an intermediate phenotype, such as sir1, consist of two dis
257 s and are not explained by associations with intermediate phenotypes, such as atopy or lung function.
259 n gene variants (polymorphisms) and measured intermediate phenotypes, such as lipid/lipoprotein level
260 he study of complex traits, as it integrates intermediate phenotypes, such as RNA, protein, and metab
261 tistical methods to quantitate and integrate intermediate phenotypes, such as transcript, protein or
262 kleback hybrids beyond that expected from an intermediate phenotype, suggesting a role for epistasis
263 are wild-type mice, MCP-1(-/-) mice have an intermediate phenotype, suggesting that other CCR2 ligan
264 out of the four mutant Fgf alleles revealed intermediate phenotypes, suggesting a quantitative requi
265 ulture under suboptimal levels of FSS led to intermediate phenotypes, suggesting a threshold effect.
266 er residues could be mutated to give rise to intermediate phenotypes, suggesting they have a role in
267 ed constructs can identify receptors with an intermediate phenotype that contribute to epileptic phen
268 the FII 20210G>A and FVL mutations share an intermediate phenotype that is characterized by increase
269 iameter (LAD) and low voltage area (LVA) are intermediate phenotypes that are associated with AF type
270 III and von Willebrand factor (vWF) are four intermediate phenotypes that are heritable and have been
272 ny psychiatric disorders are associated with intermediate phenotypes that can be modeled and studied
273 mal studies, including the identification of intermediate phenotypes that can be studied across speci
274 s validated the candidate gene, and included intermediate phenotypes that co-segregated with the in-f
275 r autonomic dysfunction syndromes, including intermediate phenotypes that contribute to human hyperte
277 four-state system consisting of two distinct intermediate phenotypes that differ in differentiation p
278 onses to infused angiotensin II (Ang II) are intermediate phenotypes that may indirectly reflect tiss
279 ith psychiatric illness, providing potential intermediate phenotypes that span diagnostic categories.
280 le and although the absence of Fyn causes an intermediate phenotype, the combined absence of Src and
281 repeated magnetic resonance scans (i.e., an 'intermediate phenotype.') The method combines a machine-
283 functional fine-mapping approach, leveraging intermediate phenotypes to identify functional variant(s
285 ates genetic predisposition to low PA (i.e., intermediate phenotype) to mitigate the genetic influenc
286 and metabolic conditions served as in-vitro intermediate phenotypes underlying the association betwe
287 ed features may lend further insight into an intermediate phenotype vulnerable for alcohol use and ad
288 t a quantitative biomarker can be used as an intermediate phenotype when investigating the associatio
289 en of the population, and we propose steps ("intermediate phenotypes") whereby in a sex-dependent fas
290 to partition engraftment resistance into its intermediate phenotypes, which are firstly the immune-me
291 le neutralization-sensitive, -resistant, or -intermediate phenotypes, which are independent of genoty
292 ns of these pathways with AF-related cardiac intermediate phenotypes, which included electrocardiogra
293 lted in a modest expansion of effectors with intermediate phenotypes, which were capable of persistin
295 dorsal anterior cingulate may constitute an intermediate phenotype with low effect size for psychosi
296 he mutation of the C-terminal SIM yielded an intermediate phenotype with nuclear and cytoplasmic stai
297 e expression data and other disease relevant intermediate phenotypes with GWAS results could potentia
298 area will require better characterization of intermediate phenotypes with large effect size for the c