ライフサイエンスコーパス: intermediate state

1 ed to extract the molecular constants of the intermediate state.

2 d to follow the population flux through each intermediate state.

3 nt were expressed, having a dark stable blue intermediate state.

4 antly disulfide chemistry, as well as to any intermediate state.

5 lence electronic structure of this transient intermediate state.

6 by preventing the formation of the misfolded intermediate state.

7 ied a structural model of an ApoE4 misfolded intermediate state.

8 ative manner compatible with the coiled-coil intermediate state.

9 the virus in a previously undescribed early intermediate state.

10 t will do so by altering the stability of an intermediate state.

11 rwards or backwards from any light-activated intermediate state.

12 e main contributions in the formation of the intermediate state.

13 pin 2, which facilitates the emergence of an intermediate state.

14 newly discovered site, Na1'', near S1, as an intermediate state.

15 ch lineage differentiation passes through an intermediate state.

16 ations: resting, activated and a short-lived intermediate state.

17 ce of the hemifused diaphragm of the prepore intermediate state.

18 on of a compact and transient molten globule intermediate state.

19 -type asparaginase structure in the covalent intermediate state.

20 EMT for the lung cancer cells shows a stable intermediate state.

21 nt tissues, increases the population of this intermediate state.

22 r region for allosteric communication in the intermediate state.

23 ed the probability of contents mixing in the intermediate state.

24 and the flavin chromophore to form a radical intermediate state.

25 water-soluble oligomer represents a prepore intermediate state.

26 1 voltage-gated potassium channel VSD in the intermediate state.

27 the native conformation and a well-populated intermediate state.

28 get cells by Envs in an extended pre-hairpin intermediate state.

29 erstanding whether LLPS is an equilibrium or intermediate state.

30 e melanocytic and mesenchymal states and the intermediate state.

31 conformation as well as two highly populated intermediate states.

32 pture the altered virus in what appear to be intermediate states.

33 structural transitions, populating distinct intermediate states.

34 native structures that possibly lead to such intermediate states.

35 inate between potential structural models of intermediate states.

36 be invariant to energy perturbations of the intermediate states.

37 s but instead proceeds with multiple partial intermediate states.

38 of mechanistic information on transient and intermediate states.

39 critical in achieving and selecting between intermediate states.

40 ulate TL folding in a constrained pathway of intermediate states.

41 ion and identify two previously unidentified intermediate states.

42 les decreased during progression through the intermediate states.

43 the K48 linkage model successfully predicted intermediate states.

44 ual-area-dominant, frontal-area-dominant and intermediate states.

45 ssembly and visualize structural features of intermediate states.

46 could complicate fine mapping of the various intermediate states.

47 al load, and it has been shown to unfold via intermediate states.

48 tated by their binding free energies with no intermediate states.

49 sociation and hydrogen generation from their intermediate states.

50 op multi-value logic transistors with stable intermediate states.

51 en to be independent of the stability of the intermediate states.

52 ve and active states-at least two metastable intermediate states.

53 BDI systems leads to a zwitterionic twisted intermediate state ((1)p*) and that destabilizing the (1

54 The prolonged intermediate state allowed us to identify protein substr

55 Hence, residence in a specific intermediate state along the E-M spectrum rather than ph

56 sted that pore formation constitutes only an intermediate state along the route of PG-1's membrane di

57 rved in individual cohesin-depleted cells as intermediate states along a folding pathway that leads t

58 nal computations on structural models of the intermediate states along the conformational transition

59 ing mechanism and identify the most relevant intermediate states along the reaction pathway.

60 The intermediate state also facilitates transition of the fi

61 ryotic neurotransmitter receptors, for which intermediate states also participate in activation.

62 rom luminal cells, possibly via a basal-like intermediate state, although further study using a diffe

63 The simulations also revealed intermediate states, among which a unique DFG-out/alpha-

64 distinct conformational states, including an intermediate state and a post-translocational state.

65 ial activation from the resting state to the intermediate state and activated state to trigger pore o

66 molecular nitrogen via the a(1)Pai(g)(v = 6) intermediate state and analyse its feasibility to genera

67 one to trigger formation of the FI-sensitive intermediate state and another to facilitate subsequent

68 bservations to the existence of at least one intermediate state and at least two energy barriers in t

69 th trajectories originate from an on-pathway intermediate state and compete with native folding in a

70 is work illuminates the structure of the VSD intermediate state and demonstrates that intermediate st

71 RRM2 construct reduce the population of the intermediate state and enhance DNA/RNA binding.

72 are required for the generation of the early intermediate state and fully reprogrammed iPS cells, and

73 These results provide a detailed view of an intermediate state and illustrate the opportunities offe

74 nergic antagonist completely eliminated this intermediate state and instantaneously restored awake dy

75 ge: a nearly instantaneous crossover into an intermediate state and its decay led by lattice instabil

76 ide chains of H40 and H47 are exposed in the intermediate state and undergo significant conformationa

77 Intermediate states and allosteric behavior are difficul

78 rticular, it allows us to identify potential intermediate states and compare them to the experimental

79 rticular, it allows us to identify potential intermediate states and compare them to the experimental

80 dynamics simulations to identify metastable intermediate states and the dynamics of backtracking at

81 rgy of the transition barriers that separate intermediate states and the dynamics of two bilayers as

82 However, the nature of the intermediate states and the underlying mechanism of ultr

83 ur analysis identifies distinct transitional intermediate states and their divergent developmental tr

84 cription factors (i.e. removing the unstable intermediate states), and that crowding by large molecul

85 the channel: two closed state structures, an intermediate state, and an open state, each embedded in

86 fewer neural transitions due to an unstable intermediate state, and these infrequent transitions pre

87 re, we describe the native state, observable intermediate state, and unfolded state for ETR-3 RRM-3,

88 f the topology of the network connecting the intermediate states, and are therefore capable of descri

89 ence and distant metastasis were included as intermediate states, and deaths from breast cancer, seco

90 uronate, in both native and covalently bound intermediate states, and galacturonate provide insights

91 ize two alternative native structures, three intermediate states, and numerous misfolded states, the

92 heet core forms early and is present in both intermediate states, and the rate-limiting step which is

93 -bound inactive state; 2), the agonist-bound intermediate state; and (3), the agonist- and G-protein-

94 The origins of formation of an intermediate state are elucidated, viz.

95 for Na(+) and aspartate obtained using this intermediate state are in good agreement with the experi

96 These intermediate states are believed to represent discrete U

97 romatin states is highly cooperative, and no intermediate states are found along the transition path.

98 in linear molecules, we demonstrate that no intermediate states are involved in the triplet formatio

99 tracking occurs in a stepwise mode where two intermediate states are involved.

100 However, the functions of these intermediate states are not fully understood.

101 However, the solution returns many of the intermediate states back to the reactants before the pro

102 eal that ATAD5-RLC unloaded PCNA through one intermediate state before ATP hydrolysis.

103 ions of the agonist-bound receptor to closed intermediate states before opening (priming).

104 ur analysis shows that NAT presents a unique intermediate state between healthy and tumor.

105 gometastatic disease has been proposed as an intermediate state between localised and systemically me

106 This alteration may reflect an intermediate state between normal innervation and comple

107 netic analysis confirmed the existence of an intermediate state between photoexcitation and proton tr

108 can be achieved through the emergence of an intermediate state between the working memory states.

109 m state without requiring the preparation of intermediate states between the initial and target state

110 interaction with the hydrophobic core in the intermediate state but is released from the core in the

111 isfolding occurs via a transiently populated intermediate state, but our structural understanding of

112 n pathways arising from the mere presence of intermediate states, but decreases if the contacts in th

113 of its tertiary folding and Mg(2+)-dependent intermediate states by observing selected nucleobases th

114 weezers can track the pseudoknot's unfolding intermediate states by pulling the RNA chain from both e

115 he steady states that correspond to E, M and intermediate states by varying one or two parameters at

116 with the folding of the unfolded state to an intermediate state, by the use of microsecond mixing exp

117 initial bimolecular association to form the intermediate state can be mediated by many possible cont

118 The existence of an ApoE4-specific intermediate state can contribute to the onset of AD by

119 rmore, we find that increasing the number of intermediate states can accelerate the EMT process and t

120 c rates, bond lifetimes, and the presence of intermediate states, can be determined.

121 esize that mutations destabilizing the ApoE4 intermediate state change hinge region dynamics, which p

122 oE variants, only ApoE4 exhibits a misfolded intermediate state characterized by isoform-specific dom

123 VSD intermediate state and demonstrates that intermediate state conductivity contributes to the unusu

124 s in a three-state process by populating one intermediate state consisting of a folded C-domain and a

125 modeling and experiments, we found multiple intermediate states contributing to EMT and that the rob

126 The intermediate state corresponded closely to a late-foldin

127 loid phase either is maximized or reaches an intermediate state, depending on the deleterious mutatio

128 tin architecture and "spring" to a transient intermediate state directed by DNA sequence information.

129 a linear, stepwise bending mechanism with an intermediate state distinguished by a distinct bending a

130 The structures of the intermediate states do not change significantly with mut

131 ndicate that the new structure represents an intermediate state during the transition of the clamp fr

132 osis: one in its resting state and one at an intermediate state during turnover.

133 Our data elucidated intermediate states during antibiotic recognition and su

134 To probe intermediate states during unfolding and oligomerization

135 In fact, the presence of an intermediate state eliminates such a correlation between

136 er conditions to maximize the populations of intermediate states, eliminating the guesswork of curren

137 rajectory samples multiple metastates and an intermediate state en route to the excited state.

138 l) to highly invasive (hemochorial), with an intermediate state (endotheliochorial) as found in carni

139 logy by steering the structure to functional intermediate states; enhancing tunneling events; and opt

140 ed that for all water models, the closed and intermediate states exhibited strong dewetting within th

141 en together, these analyses indicate that an intermediate state exists and is driven by a distinct an

142 multiple energy barriers and visits various intermediate states far from the binding pocket, while s

143 d a conformational flip of the channel as an intermediate state following the ligand binding and quan

144 nal hexapeptide triggers the formation of an intermediate state for folding and aggregation with an u

145 h consensus can be enhanced when there is an intermediate state for indecisive individuals to pass th

146 ectron microscopy reveals a potential fusion intermediate state for uncleaved trimers containing shor

147 mes enables the interrogation of the various intermediate states formed during the reaction.

148 surements revealed that oligomers adopted an intermediate state found during the transition between m

149 wing MT ends by recognizing and promoting an intermediate state generated during GTP hydrolysis.

150 zing (ATPh) and ATP-gammaS conformations, an intermediate state has been found.

151 structure of a potassium channel VSD in the intermediate state has previously proven elusive.

152 The open and intermediate states have a unique open dodecameric ring.

153 ates eversion of oxoG by stabilizing several intermediate states, helping the rapidly sliding enzyme

154 y favor spontaneous untethering to a compact intermediate state, here validated by small-angle X-ray

155 ansits between two major brain states via an intermediate state, high-functioning adults with ASD sho

156 allow to switch the ferroic state through an intermediate state in a continuous manner, resulting in

157 extractant complexes at the interface are an intermediate state in the extraction process, characteri

158 d debates about the possible existence of an intermediate state in the folding pathway have arisen.

159 on, indicating that they report a pre-active intermediate state in the transition pathway toward acti

160 tify the 1d texture as the equivalent of the intermediate state in type I superconductors.

161 An intermediate state in which one DNA arm is unwrapped, pr

162 This method has the ability to detect the intermediate states in addition to electrical on and off

163 are conventionally separated in three parts: intermediate states in chemical and photochemical reacti

164 FeFe] enzymes based on the identification of intermediate states in equilibrium and steady state expe

165 tau promotes the formation/stabilization of intermediate states in MT assembly and disassembly by pr

166 ynamics and enzymatics and the resolution of intermediate states in reactions over timescales of 100

167 ng Mhp1 crystal structures represent sampled intermediate states in solution.

168 profiles determined by BXD suggest that the intermediate states in talin rod subdomains are stabiliz

169 , we examine the kinetic competency of these intermediate states in the [FeFe] hydrogenase from Chlam

170 n by X-ray surface scattering of interfacial intermediate states in the extraction process.

171 tion of tightly apposed membranes, which are intermediate states in the process of mitochondrial fiss

172 ey suggest the stable characteristics of the intermediate states in the T cell differentiation.

173 ng' mutations favour structurally 'unlocked' intermediate states in the transport cycle exhibiting in

174 n(4)CaO(x) complex, which passes through >=5 intermediate states in the water-splitting cycle.

175 that CAP activates transcription by inducing intermediate state, in addition to the previously propos

176 eres requires formation and resolution of an intermediate state, in which the cell cycle-dependent Cc

177 ls are transdifferentiated through a plastic intermediate state induced by exposure to non-integrativ

178 in which cells transition through a plastic intermediate state, induced by brief exposure to reprogr

179 The origins of formation of an intermediate state involved in amyloid formation and way

180 of the role of the short-lived and reactive intermediate states involved, will be critical for such

181 e long-lived Mn excited state serving as the intermediate state is considered as the pathway generati

182 This intermediate state is corroborated by a distinct chromat

183 An intermediate state is discovered on the sodium release p

184 lyzed by the chloroplast cytochrome b6f This intermediate state is formed by interaction of a radical

185 One major intermediate state is identified along the conformationa

186 The structure of this intermediate state is identified to be monoclinic, but m

187 AtLEGbeta the plant-characteristic two-chain intermediate state is stabilized by hydrophobic rather t

188 Knowledge of the structures of these intermediate states is invaluable to the development of

189 a-helical conformation, a closed (resting or intermediate) state is stabilized rather than destabiliz

190 Finally, the physiological relevance of the intermediate state KCNQ1 conductance is demonstrated usi

191 ogether with a self-consistent update of the intermediate state lifetimes, we compute and converge th

192 crystal momenta and depend critically on the intermediate state lifetimes.

193 The intermediate state may also serve as a molecular hazard

194 Emission from a dipole forbidden intermediate state may even dominate the corresponding x

195 The cluster analysis suggests that the intermediate state may play a functional role by enhanci

196 The time spent in the intermediate state must be relatively short compared to

197 ding of the first two Na(+) ions involves an intermediate state near the Na1 site, where two Na(+) io

198 on of electrons shortens the lifetime of the intermediate state O(640) from 37.3 mus to 20.1 mus, wha

199 Ms and which are discussed in the context of intermediate states observed in live cells.

200 ed in the structural modeling of equilibrium intermediate states observed in single-molecule experime

201 nd reversible unsuccessful excursions to the intermediate state occur.

202 al descriptions of singlet fission invoke an intermediate state of a pair of spin-triplet excitons co

203 he presence of a novel allosteric site in an intermediate state of c-src that could be potentially us

204 mission electron microscopy study reveals an intermediate state of condensed atomic clusters during P

205 duction in the ocean fixed-N inventory at an intermediate state of deoxygenation may represent a biog

206 a model for part of the putative pre-hairpin intermediate state of gp41.

207 ium (E8) captures hPSCs at a naive-to-primed intermediate state of pluripotency expressing several na

208 hat this LBD configuration corresponds to an intermediate state of receptor activation.

209 n a compact EF-G conformation that favors an intermediate state of ribosomal subunit rotation.

210 nt in other microsporidia, and represents an intermediate state of rRNA reduction.

211 we investigated the equilibrium (un)folding intermediate state of T4 phage gene product 45 (gp45, al

212 hermore, we describe a novel structure of an intermediate state of the protein with the external thin

213 ptor-bound conformation and may represent an intermediate state of the trimer.

214 rated by Regulatory Networks) to explore the intermediate states of an EMT model network by computing

215 In the intermediate states of dephosphorylation the A-domain re

216 orrect response was finally given, providing intermediate states of evidence accumulation and respons

217 ssembly where each mode implicates different intermediate states of fusion that have been recently id

218 By definition, bistability arises when intermediate states of gene expression are rendered unst

219 se complex entities, by identifying possible intermediate states of operons.

220 tural knowledge of the folded, unfolded, and intermediate states of P4-P6 RNA.

221 nanocrystals to obtain initial structures of intermediate states of photosystem II catalysis at the s

222 chemical characteristics of the resting and intermediate states of phytochromes and other photorecep

223 Little is known about the intermediate states of the F refolding process.

224 , crystal structures were obtained for three intermediate states of the Geobacillus stearothermophilu

225 h-resolution equipment needed to capture the intermediate states of the transformations.

226 Through a comparative study on the intermediate states of the zinc-bound native CA II and n

227 vement of Lipid II is not understood because intermediate states of this process have not been observ

228 t structures of two transcription initiation intermediate states of yeast mtRNAP that explain promote

229 bound TRPM2 structures in two-fold symmetric intermediate states, offering a glimpse of the structura

230 To address the possible existence of an intermediate state on the folding pathway, we measure th

231 RFC loaded PCNA through two intermediate states on DNA, separated by ATP hydrolysis.

232 ify the exchange and measure the lifetime of intermediate states on the millisecond time scale.

233 At each intermediate state, one heptad repeat of the coiled coil

234 pulation by counteracting the benefit of the intermediate state or making it virtually impossible for

235 ent stability differences between native and intermediate states over the pH range 5.5-6.5 and they s

236 e interactions during assembly, i.e., within intermediate states preceding the final nucleocapsid str

237 imental approaches, which can rarely capture intermediate states present at low populations.

238 P2 conformational equilibrium in favor of an intermediate state primed for NPC1 binding.

239 owever, this model requires a non-functional intermediate state prior to the compensatory change.

240 patially extended states, functioning as the intermediate states prior to the formation of Frenkel ex

241 he role of a nonannular lipid site in the E2 intermediate state remains elusive.

242 Scattered evidence indicates that additional intermediate state(s) may exist.

243 sed alphaIIbbeta3 headpiece crystals induced intermediate states similarly to RGDSP.

244 In the intermediate state, SPs are bound only to MCP pentons an

245 that vinculin activation may proceed from an intermediate state stabilized by partial talin-vinculin

246 CD4 binding induces an intermediate state (State 2), followed by an open confor

247 These intermediate states stochastically transition between ea

248 rane fusion that extends the lifetime of the intermediate state targeted by FIs.

249 NTP, or in elevated MgCl2 concentrations, an intermediate state termed the "nucleotide-binding" state

250 nsiderably more tertiary interactions in the intermediate states than results from previous NMR studi

251 These native basins are connected through an intermediate state that builds up upon binding to the NT

252 The intermediate state that co-expresses the two opposing ma

253 subset of contractile SMCs into an MSC-like intermediate state that generated osteoblasts, chondrocy

254 ding model for RRM2, with a partially folded intermediate state that is not observed in RRM1.

255 These levels provide intermediate states that act as "stepping stones" for el

256 th behavioural gregarisation proceed through intermediate states that are not simply partial realisat

257 Between the two transitions, there are intermediate states that are spectrally isolated here.

258 icity is determined by one or more transient intermediate states that serve as selectivity filters an

259 V3 in temperature-dependent open, closed and intermediate states that suggest two-step activation of

260 When the S4 segment transitions to the intermediate state, the hand-like C-terminus of the VSD-

261 From this intermediate state, the single photon of interest is the

262 minimum free-energy path of the first fusion intermediate state, the so-called stalk.

263 Via two previously unidentified intermediate states, the RNA chain is seen to be pulled

264 Disruption of this intermediate state through mutation reduces both associa

265 domain to the IC domain are weakened in the intermediate state, thus decoupling the EC domain from t

266 conversion of TD eliminates the pluripotent intermediate state to create cells that are ideal for pe

267 axing to a shorter DNA-ligand complex in the intermediate state to form a molecular lock.

268 When the VSD activates from the intermediate state to the activated state, the VSD-pore

269 erentiate through stereotypical sequences of intermediate states to generate particular mature fates.

270 nuous scale from crystalline, through glassy intermediate states, to chaotic configurations.

271 onal shift from a compact, but heterogeneous intermediate state toward the completely formed set of t

272 Last, a stabilized intermediate state traps cells in one partial EMT state.

273 for the possibility of these lipids to form intermediate states typically associated with membrane f

274 sembly proceeds via a membrane-bound prepore intermediate state, typically consisting of up to approx

275 uitin (Ub), which is known to form nonnative intermediate states under a variety of mildly denaturing

276 We find that MalFG alone exists in an intermediate state until MalK binds and converts the mem

277 imental setup sets the lifetime of potential intermediate states upon barnase folding/unfolding in th

278 Our study of transient intermediate states using time-resolved optical and X-ra

279 via parallel pathways on which there are two intermediate states very similar to wild-type UCH-L1.

280 h changes as the structures unfolded through intermediate states was compared to the results from opt

281 d thermal relaxation procedures, a number of intermediate states was generated and analyzed by DNP-en

282 Despite folding via common intermediate states, we show that the decreased populati

283 been suggested that lamprey may represent an intermediate state where nested Hox expression has not b

284 Our study defines a unique preinsertion intermediate state where the SecA two-helix finger appea

285 cess to the SecYEG complex via a lipid-bound intermediate state, whereas acidic phospholipids alloste

286 rotein beta2-microglobulin that folds via an intermediate state which is believed to be responsible f

287 Furthermore, possible intermediate states which disrupt membranes at pH 6.4 we

288 tly observed an adduct- and mismatch-induced intermediate state, which may be an obligatory step in t

289 first structural model of an ApoE4 misfolded intermediate state, which may serve to elucidate the mol

290 ne insertion of pHLIP involves at least four intermediate states, which are believed to be linked to

291 g damping due to resonant scattering into an intermediate state with a pair of overdamped Leggett mod

292 epithelial cells that naturally exist in an intermediate state with bidirectional differentiation po

293 mutants of OXA-24/40 that arrest at the acyl-intermediate state with carbapenem substrates but mainta

294 psulated core-shell structure) to obtain the intermediate state with desirable exposure of metal site

295 ture experiment confirms the existence of an intermediate state with disordered bonds.

296 rmined the three-dimensional structure of an intermediate state with increased conformational space s

297 de-bound state, high-energy outward-occluded intermediate state, with a defined ligand binding cavity

298 ot glutamate neurons, relies on quasi-stable intermediate states, with a pool of GABA progenitors giv

299 plexes are either ejected intact or in known intermediate states, with core subunit interactions main

300 ssociation proceeds through a complex set of intermediate states, with successful binding events init