ライフサイエンスコーパス: intermembrane space

1 lipids in a lipid-specific manner across the intermembrane space.

2 membrane with the C and N termini facing the intermembrane space.

3 which reduce i-AAA protease activity in the intermembrane space.

4 brane a second time to finally reside in the intermembrane space.

5 ner membrane, and matrix or trap them in the intermembrane space.

6 rane protease following translocation to the intermembrane space.

7 ch protein substrates into the mitochondrial intermembrane space.

8 urolastin is imported into the mitochondrial intermembrane space.

9 ated by a highly conserved linker facing the intermembrane space.

10 (wtHTT) and mHTT reside in the mitochondrial intermembrane space.

11 the mitochondrial inner membrane facing the intermembrane space.

12 is a peripheral protein of the IM facing the intermembrane space.

13 freely between the cytosol and mitochondrial intermembrane space.

14 ns in the maintenance of proteostasis in the intermembrane space.

15 ome c and smac/DIABLO from the mitochondrial intermembrane space.

16 tase, but is also found in the mitochondrial intermembrane space.

17 isoforms were predicted to be soluble in the intermembrane space.

18 ane, whereas the C-terminal domain faces the intermembrane space.

19 he small Tim proteins into the mitochondrial intermembrane space.

20 one the hydrophobic Tim23 across the aqueous intermembrane space.

21 ed in the cytoplasm and in the mitochondrial intermembrane space.

22 ugh partially localized to the mitochondrial intermembrane space.

23 tive protease localized in the mitochondrial intermembrane space.

24 te-binding site is open to the mitochondrial intermembrane space.

25 DP to AMP by adenylate kinase located in the intermembrane space.

26 brane helices, shielding it from the aqueous intermembrane space.

27 the mitochondrial inner membrane facing the intermembrane space.

28 small molecules pass between the cytosol and intermembrane space.

29 e with the beta-folded P0-cyt located at the intermembrane space.

30 mu-calpain, are present in the mitochondrial intermembrane space.

31 e, suggesting its functional role within the intermembrane space.

32 ly associated with the inner membrane in the intermembrane space.

33 e inner mitochondrial membrane and faces the intermembrane space.

34 proapoptotic factors from the mitochondrial intermembrane space.

35 shown to be exposed within the mitochondrial intermembrane space.

36 ool of cytochrome c within the mitochondrial intermembrane space.

37 3p for assembly into a 70-kDa complex in the intermembrane space.

38 ane protein, whereas Mgm1p is located in the intermembrane space.

39 he nucleus and imported to the mitochondrial intermembrane space.

40 ed to be the copper donor to Sco1 within the intermembrane space.

41 and that the site in subunit MWFE is in the intermembrane space.

42 ed in both the cytosol and the mitochondrial intermembrane space.

43 nus facing the cytosol and C terminus in the intermembrane space.

44 polysialylation regulates cell adhesion and intermembrane space.

45 on site, is situated immediately next to the intermembrane space.

46 m the matrix but not O2- generation from the intermembrane space.

47 atrix and O2(-)(radical) production from the intermembrane space.

48 ath factors sequestered in the mitochondrial intermembrane space.

49 O2(-)(radical) into the matrix and into the intermembrane space.

50 al quality control mechanisms present in the intermembrane space.

51 l fraction was detected in the mitochondrial intermembrane space.

52 onverted to H2O2 by Mn-SOD) but not into the intermembrane space.

53 on of Cox17 is confined to the mitochondrial intermembrane space.

54 The protein has also been targeted to the intermembrane space.

55 ondrial matrix and the N-terminus facing the intermembrane space.

56 aggregation as the preprotein traverses the intermembrane space.

57 mitochondria with the C-terminus facing the intermembrane space.

58 membrane with it's C-terminus exposed to the intermembrane space.

59 ial proteins, including many proteins of the intermembrane space.

60 phobic carrier substrates across the aqueous intermembrane space.

61 l of Lyn and Syk reside in the mitochondrial intermembrane space.

62 ion or by artificially targeting XIAP to the intermembrane space.

63 ysteine-rich proteins into the mitochondrial intermembrane space.

64 cysteine-rich proteins in the mitochondrial intermembrane space.

65 arding how lipids transit across the aqueous intermembrane space.

66 e of mitochondria with its C terminus in the intermembrane space.

67 dase (Ccp1) is targeted to the mitochondrial intermembrane space.

68 associated (POTRA) domain extending into the intermembrane space.

69 terminal end of the protein localized to the intermembrane space.

70 f intercellular junctions and the control of intermembrane spacing.

71 fluctuations are substantially modulated by intermembrane spacing.

72 and poly-A polymerase, in the mitochondrial intermembrane space, a location lacking resident RNAs.

73 expressed at low levels are degraded by the intermembrane space AAA (i-AAA) protease, suggesting mis

74 The relationship between intermembrane spacing, adhesion efficiency, and lateral

75 lipid transfer proteins in the mitochondrial intermembrane space, allowing formation of PE by Psd1 in

76 The presence of this peptidoglycan in the intermembrane space allows the refinement of a model for

77 localization of Prx1: a soluble form in the intermembrane space and a form in the matrix weakly asso

78 cytochrome c release from the mitochondrial intermembrane space and apoptosis.

79 rosomes, Osm1 localizes to the mitochondrial intermembrane space and assembles with Erv1 in a complex

80 motif mitochondrial protein localized in the intermembrane space and associated with the inner membra

81 ed both by their presence in the constrained intermembrane space and by the 2D environment of membran

82 tosis-inducing factor from the mitochondrial intermembrane space and can cause the cleavage of full-l

83 ive literature on proteins released from the intermembrane space and consider genetic evidence for an

84 reases in ROS signaling in the mitochondrial intermembrane space and cytosol, and it abrogated hypoxi

85 matrix by superoxide that originates in the intermembrane space and diffuses across the inner membra

86 10 is a mitochondrial protein located in the intermembrane space and enriched at cristae junctions.

87 ein that exposes its carboxy-terminus to the intermembrane space and exists in several complexes of 6

88 approach to express SOD1 exclusively in the intermembrane space and found that mitochondrial SOD1 is

89 antimycin induced O2(-)(radical) toward the intermembrane space and inhibited H2O2 generation from t

90 it was reported that mHTT is present in the intermembrane space and inhibits mitochondrial protein i

91 isoenzyme is expressed in the mitochondrial intermembrane space and is mutated in reticular dysgenes

92 ation-prone proteins enter the mitochondrial intermembrane space and matrix after heat shock, and som

93 y the Mia40 oxidative-folding pathway in the intermembrane space and probably stabilize the membrane

94 alization of mu-calpain to the mitochondrial intermembrane space and provides new insight into the po

95 s have a specialized assembly pathway in the intermembrane space and that the local redox state of th

96 tosis-inducing factor from the mitochondrial intermembrane space and the cleavage of full-length Bid

97 8's and Pam16's N termini interacting in the intermembrane space and the matrix, respectively.

98 ion of 0.94 A), whereas the loops facing the intermembrane space and the mitochondrial matrix are les

99 er membrane, which in turn is bounded by the intermembrane space and the outer membrane.

100 e-protein adsorption mechanisms that affects intermembrane spacing and adhesion and has direct implic

101 rom translocation from the cytosol (into the intermembrane space) and partly from caspase-mediated ac

102 e with the FAD binding domain exposed to the intermembrane space, and 3) the ability of recombinant C

103 n, a sulfhydryl oxidase of the mitochondrial intermembrane space, and a larger protein containing the

104 whose hydrophilic domains are located in the intermembrane space, and Cox20 remains associated with m

105 , localized to the cytosol and mitochondrial intermembrane space, and Grx2, localized primarily to th

106 ling molecules such as cytochrome c from the intermembrane space, and irreversible injury to the mito

107 d in the major compartments (outer membrane, intermembrane space, and the matrix) of the organelle is

108 When calcium levels in the intermembrane space are high, the N-terminus of the amph

109 ia demonstrated that DSP18 is located in the intermembrane space as a peripheral membrane protein of

110 ropose that a set of stacked rings spans the intermembrane space, as has been found for type III secr

111 ria accommodates the essential mitochondrial intermembrane space assembly (MIA) machinery that cataly

112 The mitochondrial intermembrane space assembly (MIA) pathway is generally

113 ydryl oxidase Erv1, termed the mitochondrial intermembrane space assembly (MIA) pathway.

114 the intermembrane space by the mitochondrial intermembrane space assembly pathway that couples their

115 shown previously that Mgm1p localizes to the intermembrane space, associated with the inner membrane.

116 ssion electron microscopy revealed increased intermembrane spacing at ID sites adjacent to gap juncti

117 e1 mediated translocation of PNPase into the intermembrane space but did not degrade PNPase.

118 sulfhydryl oxidase within the mitochondrial intermembrane space but may communicate with the respira

119 Interestingly, PNPase is localized to the intermembrane space by a novel import pathway.

120 d c1 are converted to their holoforms in the intermembrane space by attachment of heme to the cystein

121 f DAG in the leaflets facing the chloroplast intermembrane space by DAGK impairs plant growth.

122 mbrane and is subsequently released into the intermembrane space by proteolytic removal of a hydropho

123 Mitochondrial proteins are targeted to the intermembrane space by the mitochondrial intermembrane s

124 g in both neuronal cytosol and mitochondrial intermembrane space, calpain I was found to be activated

125 vely reside in the cytosol and mitochondrial intermembrane space, can engage negatively charged bilay

126 chondrial inner membrane and consists of two intermembrane space chaperone complexes, the Tim9-Tim10

127 Human Tim8a and Tim8b are members of an intermembrane space chaperone network, known as the smal

128 , to examine the in vitro degradation of two intermembrane space chaperone subunits, Tim9 and Tim10.

129 ase and confirm that Mgm1p is present in the intermembrane space compartment in vivo.

130 interact via their C-terminal domains in the intermembrane space, consistent with their in vivo topol

131 the small Tim proteins of the mitochondrial intermembrane space contain a consensus twin CX3C Zn2+-f

132 Cox19 isolated from the mitochondrial intermembrane space contains variable quantities of copp

133 in pumping protons from the matrix into the intermembrane space contributing to the proton motive fo

134 in pumping protons from the matrix into the intermembrane space contributing to the proton motive fo

135 ined the crystal structure of the conserved, intermembrane space core portion of apo-hSCO1 to 2.8 A.

136 e oxidation takes place in the mitochondrial intermembrane space, delivering electrons to the respira

137 p directly interacts with Fzo1p, whereas its intermembrane space domain binds to Mgm1p.

138 The intermembrane space domain of Mic60 has a lipid-binding

139 Ablation of the intermembrane space domain of the translocase subunit, a

140 We report the crystal structure of the intermembrane space domain of yeast Tim50 to 1.83 A reso

141 Notably, the transmembrane and intermembrane space domains are separated from the main

142 Here, we show that the conserved intermembrane-space dynamin-related GTPase Mgm1 is requi

143 sistant fold, associates non-integrally with intermembrane space-facing membranes and assembles in a

144 he central region of Tim23, which enters the intermembrane space first, may serve to nucleate the bin

145 HtrA2/Omi is released from the mitochondrial intermembrane space following apoptotic stimuli.

146 -Tim13 complex, located in the mitochondrial intermembrane space, functions in the TIM22 import pathw

147 olipid, cardiolipin (CL), is oxidized by the intermembrane-space haemoprotein, cytochrome c.

148 n protein translocation, indicating that the intermembrane space harbors diverse pathways for protein

149 The mitochondrial intermembrane space has an analogous pathway with the ox

150 Expression of Opa1 CTFs in the intermembrane space has no effect on mitochondria morpho

151 peroxidase (CCP) is a 32.5 kDa mitochondrial intermembrane space heme peroxidase from Saccharomyces c

152 ane space via the redox-driven mitochondrial intermembrane space import and assembly (MIA) pathway.

153 Mitochondrial intermembrane space import and assembly protein40, a pro

154 component of a redox-sensitive mitochondrial intermembrane space import machinery.

155 , a dynamin-like GTPase of the mitochondrial intermembrane space important for maintaining cristae st

156 luorescent protein-based redox sensor to the intermembrane space (IMS) and matrix of yeast mitochondr

157 d by misfolded proteins in the mitochondrial intermembrane space (IMS) and mediated by the estrogen r

158 tochondrial membrane translocases facing the intermembrane space (IMS) and that this interaction prom

159 Once imported, PNPase localized to the intermembrane space (IMS) as a peripheral membrane prote

160 those that are targeted to the mitochondrial intermembrane space (IMS) do not require ATP or the inne

161 beta-barrel fold consisting of an N-terminal intermembrane space (IMS) domain and a C-terminal 16-str

162 ner membrane, the dynamic association of its intermembrane space (IMS) domain with the outer membrane

163 The mitochondrial intermembrane space (IMS) harbors an oxidizing machinery

164 and superoxide dismutase 1 (Sod1) within the intermembrane space (IMS) in yeast.

165 ast to matrix proteins, many proteins of the intermembrane space (IMS) lack presequences and are impo

166 stitute the largest group of proteins in the intermembrane space (IMS) of mitochondria.

167 iated release of DDP/TIMM8a, a mitochondrial intermembrane space (IMS) protein , into the cytoplasm,

168 logy of the mitochondria and accumulation of intermembrane space (IMS) proteins.

169 dent sulfhydryl oxidase in the mitochondrial intermembrane space (IMS) that functions in the import o

170 hatase that is targeted to the mitochondrial intermembrane space (IMS) where it interacts with the mi

171 ause Cu,Zn-SOD is found in the mitochondrial intermembrane space (IMS), we hypothesized that mitochon

172 ied to map the proteome of the mitochondrial intermembrane space (IMS), which can freely exchange sma

173 oid dehydrogenase type 2 (3betaHSD2) via its intermembrane space (IMS)-exposed charged unstructured l

174 transacylase tafazzin, which associates with intermembrane space (IMS)-facing membrane leaflets.

175 mbrane proteins facing the matrix versus the intermembrane space (IMS).

176 chondrial membranes surround the hydrophilic intermembrane space (IMS).

177 nner membrane (IM) protein facing toward the intermembrane space (IMS).

178 le is known about folding of proteins in the intermembrane space (IMS).

179 mostly on the outer membrane and inside the intermembrane space (IMS).

180 m (lfALR) which resides in the mitochondrial intermembrane space (IMS).

181 phospholipid metabolism in the mitochondrial intermembrane space (IMS).

182 ria, where it localizes predominantly in the intermembrane space (IMS).

183 reduced proteins entering the mitochondrial intermembrane space (IMS).

184 anslocated through the inner membrane to the intermembrane space (IMS).

185 and outer mitochondrial membranes facing the intermembrane space (IMS).

186 0p and Tim8p/Tim13p protein complexes in the intermembrane space (IMS).

187 may inhibit respiration directly within the intermembrane space (IMS).

188 ensitive cysteine residues reside within the intermembrane space (IMS).

189 m a structural disulfide bond exposed to the intermembrane space (IMS).

190 e oxidizing environment of the mitochondrial intermembrane space (IMS).

191 al matrix (Mito-RoGFP), or the mitochondrial intermembrane space (IMS-RoGFP), allowing assessment of

192 ls, allowing K(+) to enter the mitochondrial intermembrane space in a controlled regulated fashion.

193 3-nm particles could enter the mitochondrial intermembrane space in mitochondria of permeabilized cel

194 dative protein import into the mitochondrial intermembrane space in yeast and mammals.

195 d through these pores from the mitochondrial intermembrane space into the cytoplasm where they initia

196 otic factors including cytochrome c from the intermembrane space into the cytoplasm, where they initi

197 orine causes translocation of DSP18 from the intermembrane space into the cytosol similar to other ap

198 otic protein released from the mitochondrial intermembrane space into the cytosol, promotes apoptosis

199 e release of proteins from the mitochondrial intermembrane space into the cytosol.

200 P-independent chaperone of the mitochondrial intermembrane space, involved in transport of polytopic

201 lease of cytochrome c from the mitochondrial intermembrane space is critical to apoptosis induced by

202 sults suggest that SOD1 in the mitochondrial intermembrane space is fundamental for motor axon mainte

203 The functional significance of SOD1 in the intermembrane space is unknown.

204 ectron transport chain and released into the intermembrane space - is the cellular oxygen signal resp

205 whose extracellular domain is located in the intermembrane space, is a substrate of StoA.

206 denine nucleotide interconversion within the intermembrane space, is markedly induced during adipocyt

207 protons from the mitochondrial matrix to the intermembrane space, it builds up an electrochemical pot

208 We show that Prx1 sorting into the intermembrane space likely involves the release of the p

209 ) forms the membrane anchor, which binds the intermembrane space-localized alpha-subunit (Psd1alpha).

210 ty in which cytoplasmic Ca(2+) regulation of intermembrane space-localized MICU1/2 is controlled by C

211 s the respiratory chain to the mitochondrial intermembrane space-localized, ubiquitous, and ancient S

212 ilitated by Mrs2, and point mutations in the intermembrane space loop limits (m)Mg(2+) uptake.

213 the MOM and entering into the mitochondrial intermembrane space, making it highly unlikely that mHTT

214 mine-conjugated dextran in the mitochondrial intermembrane space of digitonin-permeabilized hepatocyt

215 sol, nucleus, peroxisomes, and mitochondrial intermembrane space of human cells.

216 The oxidative folding mechanism in the intermembrane space of human mitochondria underpins a di

217 The intermembrane space of mitochondria accommodates the ess

218 containing metalloprotein is located in the intermembrane space of mitochondria and released into bl

219 tosis, cytochrome c (cyt c) is released from intermembrane space of mitochondria into the cytosol whe

220 The release of proteins from the intermembrane space of mitochondria is one of the pivota

221 ides drives import of many proteins into the intermembrane space of mitochondria.

222 g the efficiency of oxidative folding in the intermembrane space of mitochondria.

223 and its copper chaperone CCS localize to the intermembrane space of mitochondria.

224 trols proteostasis at the inner membrane and intermembrane space of mitochondria.

225 and biogenesis of proteins localized to the intermembrane space of mitochondria.

226 We found that CPS-6 relocates from the intermembrane space of paternal mitochondria to the matr

227 h a chaperone had not been identified in the intermembrane space of plastids and we propose that Tic2

228 firmed that POTRA domains are located in the intermembrane space of the chloroplast envelope.

229 osome in which m-IL-1beta resides within the intermembrane space of the double-membrane structure.

230 Located in the cytosol and intermembrane space of the mitochondria, Sod1p likely pr

231 t, but it localizes to the cytoplasm and the intermembrane space of the mitochondria.

232 ther cellular compartments especially in the intermembrane space of the mitochondrial to avoid irreve

233 We show that this lipase is located in the intermembrane space of the mitochondrion and is imported

234 is inserted between two bilayers in a tight intermembrane space of ~3 nm, implying direct interactio

235 periplasms of bacteria and the mitochondrial intermembrane spaces of fungi.

236 as with planar bilayers demonstrated average intermembrane spacing of 12.8 nm with CD48-WT, 14.7 nm w

237 is unclear whether loss of the enzyme in the intermembrane space or cytosol is important in this resp

238 ompartments: outer membrane, inner membrane, intermembrane space, or matrix.

239 estined for the outer or inner membrane, the intermembrane space, or the matrix, proteins begin the i

240 study was used to reveal the relative matrix/intermembrane space/outer membrane (85:6:9) distribution

241 her complex I subunits as a substrate of the intermembrane space oxidoreductase CHCHD4 (also known as

242 The small Tim proteins in the mitochondrial intermembrane space participate in the TIM22 import path

243 g the potential across this membrane and the intermembrane space pH.

244 eric Tim9-Tim10 complex of the mitochondrial intermembrane space plays an important role during impor

245 locase complex, located in the mitochondrial intermembrane space, plays an essential chaperone-like r

246 sible for the transfer of disulfide bonds to intermembrane space precursor proteins, causing their ox

247 ndria, suggesting that OPA1 is cleaved by an intermembrane space protease which is regulated by activ

248 observed with knockdown of the mitochondrial intermembrane space protease Yme1.

249 in we report that the so-far-uncharacterized intermembrane space protein Mix23 is considerably up-reg

250 x activation and pro-apoptotic mitochondrial intermembrane space protein release, which are required

251 ond is the CHCHD3 homologue, CHCH-3, a small intermembrane space protein that may act as a chaperone.

252 is a developmentally regulated mitochondrial intermembrane space protein that undergoes processive cl

253 thermore, the protease Prd1, misannotated as intermembrane space protein, could be re-assigned and ch

254 Here we identify a new intermembrane space protein, Hot13p, as the first compon

255 and D sphingosine potentiate the release of intermembrane space proteins by long-chain ceramide and

256 ismutase (Sod1) requires a growing number of intermembrane space proteins containing a twin Cx(9)C mo

257 ge assembly defect and emphasize the role of intermembrane space proteins for the efficient assembly

258 ability of ceramide to induce the release of intermembrane space proteins from mitochondria in vitro.

259 y, triggered by the release of mitochondrial intermembrane space proteins into the cytoplasm.

260 , the Mia40/Erv1 pathway for import of small intermembrane space proteins participates in CCS mitocho

261 The release of mitochondrial intermembrane space proteins to the cytosol is a key eve

262 membrane permeabilization and the release of intermembrane space proteins, such as cytochrome c, are

263 haracterized by the release of mitochondrial intermembrane space proteins, such as cytochrome c.

264 quired for the cleavage of two mitochondrial intermembrane space proteins, suggesting that rhomboid p

265 n the permeability transition and release of intermembrane space proteins, the mitochondrial Ca(2+)-i

266 e, we investigated the role of the conserved intermembrane space proteins, Ups1p and Ups2p, and an in

267 In this study, we report that two homologous intermembrane space proteins, Ups1p and Ups2p, control c

268 ed to the transport and oxidative folding of intermembrane space proteins.

269 e of high levels of CCS in the mitochondrial intermembrane space results in enhanced mitochondrial ac

270 sociates with the small alpha subunit on the intermembrane space side of the inner membrane.

271 d plants, Toc75 N terminus is located on the intermembrane space side, not the cytosolic side, of the

272 eing in the mitochondrial outer membrane and intermembrane space, SOD1 is also localized in the mitoc

273 PNPase localization to the mitochondrial intermembrane space suggests a unique role distinct from

274 o replenish protons from the matrix into the intermembrane space, sustaining mitochondrial membrane p

275 ent of the protein has a function within the intermembrane space that is independent of copper ion bi

276 lectron acceptor couple in the mitochondrial intermembrane space that seems to function in both aerob

277 in yet another subcellular compartment: the intermembrane space that separates forespores from mothe

278 n mitochondria, huntingtin is located in the intermembrane space, that mHTT binds with high-affinity

279 s are by nature transient and located in the intermembrane space, this determination is generally a v

280 AC) bound to the Tim9p-Tim10p complex in the intermembrane space; this productive intermediate can be

281 articles must have entered the mitochondrial intermembrane space through the VDAC.

282 ther apoptotic factors are released from the intermembrane space through these pores, initiating down

283 e recruitment of molecular chaperones in the intermembrane space to facilitate membrane transport.

284 8a partners with TIMM13 in the mitochondrial intermembrane space to form a 70 kDa complex and facilit

285 membrane and shuttling electrons through the intermembrane space to support the bioenergetic demands

286 nsported across two membranes and an aqueous intermembrane space to the cell surface.

287 0 and Tim23 transfer preproteins through the intermembrane space to the inner membrane.

288 to acidification, whereas the mitochondrial intermembrane space (trans) side barely responded to pH

289 Two mitochondrial proteins located in the intermembrane space, Ups1p and Ups2p, have been shown to

290 cation for proteins that are targeted to the intermembrane space via the redox-driven mitochondrial i

291 the translocase of the outer membrane to the intermembrane space, where divergent pathways sort them

292 otein Opa1 is localized to the mitochondrial intermembrane space, where it facilitates fusion between

293 Mgm1/OPA1 is localized to the mitochondrial intermembrane space, where it is tightly bound to the ou

294 argeted to mitochondria and localizes in the intermembrane space, where it participates in an approxi

295 ) promotes transport of the precursor to the intermembrane space, whereas the sorting and assembly ma

296 ifunctional hemoprotein in the mitochondrial intermembrane space whereby its participation in electro

297 III is also released into the mitochondrial intermembrane space, which contains a recently identifie

298 f an Mg2+-dependent nuclease activity in the intermembrane space, which is responsible for the former

299 G activity exclusively to the mitochondrial intermembrane space with no activity associated with eit

300 cal hexameric complexes in the mitochondrial intermembrane space with phosphotransfer activity using