ライフサイエンスコーパス: internal deletion

1 4L (full ORF deletion) and Delta54S (partial internal deletion).

2 d by a naturally occurring P element with an internal deletion.

3 smid containing a cloned gene disabled by an internal deletion.

4 One of Prp40p's two NESs lies within the internal deletion.

5 minicircles by homologous recombination and internal deletion.

6 amino acid change or a protein truncation or internal deletion.

7 edium (Delta30M), and large (Delta30L) ORF30 internal deletions.

8 een examined in the context of B" with small internal deletions.

9 nd a 3'-end sequence with various degrees of internal deletions.

10 hat six of these defective derivatives carry internal deletions.

11 The smaller genomes contained internal deletions.

12 s), aberrant replication products with large internal deletions.

13 f proteins with variable N and C termini and internal deletions.

14 amilies, and a majority of the TEs contained internal deletions.

15 a final library comprising both terminal and internal deletions.

16 produce in-frame dystrophin transcripts with internal deletions.

17 Of these, 534 (72.9%) had large internal deletions, 174 (23.7%) had hypermutations, 15 (

18 .7%) had hypermutations, 15 (1.4%) had small internal deletions, 3 (1.0%) had deletions in the packag

19 Most internal deletions (52 of 54) behaved as nonautonomous D

20 on also occurs between rad52-Delta327 and an internal deletion allele missing residues 210 through 32

21 A cluster of Bdp1 internal deletions also reverses the inactivation of tra

22 Internal deletion analyses indicate that suppressor func

23 By 3' and internal deletion analyses, the region between -90 to -9

24 re analyzed using methods designed to detect internal deletion and "copyback" DIs in order to identif

25 /kat(2J) mutant animals identified a partial internal deletion and a single-base insertion as the mol

26 Internal deletion and point mutagenesis analysis of this

27 Internal deletion and point mutation of the predicted AT

28 Internal deletion and site-specific mutagenesis of the 1

29 Evaluation of internal deletion and substitution mutations identified

30 ide vector containing the acoas gene with an internal deletion and the hygromycin-resistant gene as s

31 Internal deletion and truncation mutagenesis identified

32 g apoB promoter fragments containing various internal deletions and a substitution mutation as templa

33 ion of IL-2Rbeta; however, certain IL-2Rbeta internal deletions and C-terminal truncations differenti

34 f truncations, amino acid substitutions, and internal deletions and examining the functional conseque

35 seudorabies virus (PRV), mutant viruses with internal deletions and insertions in the gG gene have sh

36 to as "defective" by virtue of having large internal deletions and lethal genetic mutations.

37 Analysis of several internal deletions and point mutants of apoA-I showed th

38 of the alpha-globin gene and the results of internal deletions and point mutations argue against a r

39 Internal deletions and point mutations demonstrated that

40 rogen receptor (AR) mutants containing small internal deletions and point mutations within the amino-

41 s, likely resulting from alternate splicing, internal deletions and/or breakpoint region insertions i

42 of more than 12 nucleotides from the 5' end, internal deletions, and one insertion in the 5' NTR resu

43 Various N- and C-terminal truncations, internal deletions, and point mutations of YFC were anal

44 clear accumulation, a series of truncations, internal deletions, and point mutations were constructed

45 Heritable internal deletions are extremely frequent (>10(-2) per e

46 However, internal deletions are rare relative to Ac excision foot

47 include canonical viral proteins with large internal deletions, as well as proteins with novel C-ter

48 und to be sensitive to small truncations and internal deletions at the toxin's amino terminus.

49 RA-induced thymic lymphosarcoma, had a large internal deletion beginning from almost the N-terminal s

50 hepatitis B virus (HBV) containing the core internal deletion (CID) mutation have been found frequen

51 characterization of naturally occurring core internal deletion (CID) variants of HBV revealed all of

52 approximately 90% of the total activity, and internal deletions confirmed that the most proximal sequ

53 A series of short internal deletions confirmed that the region between nt

54 A series of progressive and internal deletion constructs shows that enhancer sequenc

55 A series of amino-terminal truncations and internal deletion constructs were made creating forms of

56 onse of -3636 to +172, as demonstrated using internal deletion constructs.

57 By using a series of Pit-1 internal-deletion constructs in a transient transfection

58 s, including the mutant form with the EBNA-1 internal deletion, correlated directly with their chromo

59 , we have manipulated the Shh TAD - creating internal deletions, deleting CTCF sites, and deleting an

60 ning the RPS2 molecule with a small in-frame internal deletion demonstrated that RPS2 does not have a

61 uch as P and hobo have been shown to produce internal deletion derivatives at a significant rate, and

62 otein (PrP) molecules with several different internal deletions display spontaneous neurodegenerative

63 nt PER protein, produced by creating a small internal deletion, displays increased stability and low-

64 Internal deletions encompassing the internal hydrophobic

65 alyses reveal that MHs are enriched in early internal deletions even in cNHEJ-proficient B cells.

66 ilaments containing mutant tropomyosins with internal deletions exhibited exaggerated cooperativity,

67 A PodJ mutant with an internal deletion exhibits reduced sensitivity to pili-t

68 Interestingly, an internal deletion form of sigmaN lacking the major core

69 An internal deletion found in 20% of Calcutta iceA1 genes w

70 We examined the effect of an internal deletion from -1088 to -863, which includes the

71 carboxyl and amino termini of IRF5; a single internal deletion from amino acids 455 to 466 (Delta455-

72 ive nonautonomous mobile elements derived by internal deletion from ISSoc2.

73 tin, whereas a mutant receptor containing an internal deletion, GRDelta108-317, increased polyglutami

74 Further experiments using LTR mutants with internal deletions identified three regions located betw

75 otein by Edman degradation and confirmed the internal deletion in gC1(delta33-123t).

76 are naturally occurring mutants that have an internal deletion in one of their eight viral RNA (vRNA)

77 that is not a vsa gene and has undergone an internal deletion in some strains.

78 egion to the biological properties of P1, an internal deletion in spaP was engineered.

79 An internal deletion in Srs2 likewise diminishes Rad51 inte

80 that the avirulent mutant Lp120 contains an internal deletion in the gene encoding the stationary ph

81 Derivative gB(Delta717-747), with an internal deletion in the luminal juxtamembrane sequence

82 tease domain (residues 1 to 186) carrying an internal deletion in the N terminus (residues 11 to 20).

83 ruses lost sialidase activity due to a large internal deletion in the NA gene, without alteration of

84 nuated O139 vaccine strain Bengal-2, a large internal deletion in the SXT element was crossed on to t

85 An internal deletion in the V. vulnificus hupA gene, done b

86 during viral infection and typically show an internal deletion in the viral genome.

87 e we report that females heterozygous for an internal deletion in the Xist gene, which includes part

88 ation of two null y1 alleles shows a partial internal deletion in the y1 sequence.

89 An internal deletion in TonB1 was constructed in order to g

90 Several internal deletions in Bgamma abolished coimmunoprecipita

91 We report that internal deletions in MuDR arise frequently in somatic t

92 C mu gene (S mu) can undergo high-frequency internal deletions in normal B cells and B cell lines ac

93 Mutant CAT fusion proteins containing internal deletions in residues 97-120 of the galectin-3

94 eta3 splice variants are smaller and contain internal deletions in the catalytic domain.

95 bronectin expression constructs with various internal deletions in the V, III-15, or I-10 segments we

96 truncating variants (TTNtv), splice site or internal deletions in TTN in probands with mild, progres

97 n of the viral polymerase protein PB1, large internal deletions in viral genes, and failure to expres

98 ccharomyces cerevisiae Cin8p truncations and internal deletions, in order to identify structural elem

99 sylated prelamin A variant progerin, with an internal deletion including its processing site, causes

100 A series of COOH-terminal and internal deletions indicates that there is an element wi

101 that a "micro-utrophin," with more extensive internal deletions, is as effective as full-length dystr

102 is revealed viral genomes bearing very large internal deletions (LD genomes) that accumulated after o

103 ith varying extents of motility observed for internal deletions less than 75 residues and nearly comp

104 Site-directed mutations and small internal deletions made in the intact mu gene show that

105 Internal deletions mapped a shorter sequence between res

106 onoclonal antibody Alz50 was defined through internal deletion mutagenesis and quantified by affinity

107 kinetics was studied with a tropomyosin (Tm) internal deletion mutant AS-Delta23Tm (Ala-Ser-Tm Delta(

108 ull-length Tm (control) was compared with Tm internal deletion mutant Delta23Tm, which lacks residues

109 y expressing wild-type or cytoplasmic domain internal deletion mutant rabbit GHRs, brief exposure to

110 An Msn2 internal deletion mutant was insensitive to Srb10 repres

111 Cav-DeltaN2, an internal deletion mutant, also accumulated in the drople

112 aments were investigated using a tropomyosin internal deletion mutant, D234, in which actin-binding p

113 In contrast, an internal deletion mutant, Delta661-677, was also monomer

114 ted from cells transfected with truncated or internal deletion mutants indicated multiple cleavage si

115 study, a series of C-terminal truncation and internal deletion mutants of chicken gizzard smooth musc

116 tion domains, progressive NH(2)-terminal and internal deletion mutants of EKLF were constructed.

117 We have generated internal deletion mutants of p53-281G deleting conserved

118 We have generated a series of internal deletion mutants of the VDR hinge and found tha

119 Analysis of N-terminal, C-terminal, and internal deletion mutants of TraM identified two regions

120 th tropomyosin was compared with tropomyosin internal deletion mutants spanning either five or four a

121 Studies with 5'-end and internal deletion mutants suggest that elements in the d

122 Brf1 zinc ribbon and Bdp1 internal deletion mutants that are competent for polymer

123 panel of epitope-tagged PreGN truncation and internal deletion mutants was developed.

124 C-terminal rad52 truncation and internal deletion mutants were characterized for their a

125 By using internal deletion mutants, we show that this domain most

126 gion in domain interaction was examined with internal deletion mutants.

127 ng to the origin, we constructed consecutive internal deletion mutations across the core domain of a

128 Mutants carrying three internal deletion mutations in the P domain, involved in

129 collection of missense, nonsense, and a few internal deletion mutations were obtained.

130 Several p-33 proteins containing internal deletion mutations were unable to interact with

131 Neither internal deletions nor an accumulation of nucleotide cha

132 ntains exclusively dead copies with multiple internal deletions, nucleotide substitutions, and frame

133 , encoding an in-frame BRCA2 protein with an internal deletion of 105 amino acids (BRCA2(Delta105)).

134 Here we show that internal deletion of 20 amino acids corresponding to the

135 identical in sequence to TRF1 apart from an internal deletion of 20 amino acids; Pin2 and TRF1 may b

136 essing a mutant form of the protein, with an internal deletion of 246 amino acids encompassing cut re

137 F-5 bone marrow variant mutant containing an internal deletion of 288 nucleotides is not ubiquitinate

138 splice isoform that produces a protein with internal deletion of 32 amino acids in up to 50% of the

139 nt form of prelamin A (progerin) that has an internal deletion of 50 aa near the C terminus that incl

140 An internal deletion of 50 amino acids that removes this st

141 mutation that deletes exon 19 and causes an internal deletion of 51 aa in the C-terminal activation

142 to the published sequence yet it has a short internal deletion of 68 base pairs.

143 everely truncated hmw2 gene with an in frame internal deletion of 80% of the HMW2 coding region that

144 ion with an open reading frame containing an internal deletion of a portion of the C terminus or a po

145 A 714-bp internal deletion of Agamma-globin intron 2 unexpectedly

146 resulting IE2 86-kDa protein (IE2 86) has an internal deletion of amino acids 136 to 290 and is fused

147 However, an internal deletion of amino acids 147 to 233 does not abo

148 fusion protein is produced which contains an internal deletion of coding sequences derived from exons

149 subsp. lactis strains revealed evolution by internal deletion of consecutive spacer-repeat units wit

150 Internal deletion of either of these elements significan

151 An internal deletion of endonucleolytic cleavage sites prev

152 Internal deletion of EP17 resulted in loss of induction

153 of the most over looked types of mutation is internal deletion of exons.

154 Internal deletion of Gln(1624)-Arg(1641) minimally affec

155 bin promoter, an Agamma-globin gene with the internal deletion of intron 2, and a single copy of the

156 However, the internal deletion of Mtf1p revealed that the first 150-a

157 We recently reported that internal deletion of PTEN tumor suppressor gene in OPM2

158 l cytoplasm to the basolateral membrane, and internal deletion of residues 37-104 results in apical m

159 Consistently, an internal deletion of residues 50-100 of yeast eIF5 impai

160 Here we demonstrate that internal deletion of the ARID and PHD1 domains has a neg

161 Deletion of this region or internal deletion of the BOX1 motif abrogated IL-9-induc

162 Internal deletion of the C-terminal portion of the Gag p

163 Internal deletion of the CDEI binding site led only to a

164 A mutant Xdsh (Xdd1) with an internal deletion of the conserved PDZ/DHR domain was co

165 We found an internal deletion of the FAM190A gene in a pancreatic ca

166 Long MLCK with an internal deletion of the five DFRXXL motifs and the uniq

167 Internal deletion of the GFFKR motif, or point mutations

168 A form with an internal deletion of the internal conserved domain of Ga

169 An in-frame internal deletion of the lec gene was constructed and re

170 and PrP(Sc)106, we visualized the 36-residue internal deletion of the miniprion and localized the N-l

171 Furthermore, an internal deletion of the N-terminal domain of NorR activ

172 The internal deletion of the peptide E(35)KVNELsT(42) was co

173 Internal deletion of the segment between -1.57 and -1.38

174 An internal deletion of the V. vulnificus vuuA gene resulte

175 site confer GnRH induction, and mutation or internal deletion of this site reduces GnRH induction by

176 Linear and internal deletion of this WRE led to a dramatic increase

177 tic resonance (NMR) analysis showed that the internal deletion of TyrRSDeltaE2-4 SV gave an alternati

178 A targeted internal deletion of Uchl3 (Uchl3(Delta3-7)) produced vi

179 ific functions of Erb1, we constructed eight internal deletions of 40-60 amino acid residues each, sp

180 IE mutants carrying internal deletions of aa 426 to 578 and 621 to 757 were

181 icken gizzard smooth muscle CaD generated by internal deletions of amino acid sequences and expressio

182 Internal deletions of either the C-terminal portion of U

183 N-terminal, C-terminal, or internal deletions of human p22phox were generated and e

184 indicate that TRIMs are likely derived from internal deletions of large long terminal repeat retrotr

185 C-terminal and internal deletions of McpA were constructed and fused to

186 ly truncated proteins or proteins containing internal deletions of portions of the carboxyl half of N

187 Nested and internal deletions of the cpe promoter region were made

188 f or the DNA-binding homeodomain, as well as internal deletions of the N-terminal unique region, bloc

189 e that CP rescues these mutations as well as internal deletions of the Q domain within P150 and mutat

190 d the in vivo-derived DI-like segments share internal deletions of the same segments.

191 Additional work, employing sequential and internal deletions of ZEBRA's N-terminal activation doma

192 However, internal deletions of zinc fingers 5-7 completely abolis

193 nd the effect of C-terminal, N-terminal, and internal deletions on the binding of beta-tubulin polype

194 eracting with CheW, was deleted either by an internal deletion or C-terminal deletion, the resulting

195 ase phenotypes for a panel of templates with internal deletions or 3'-terminal truncations indicated

196 n chicken cells, AS TERT variants containing internal deletions or insertions that eliminated or redu

197 ype III mechanism, derivatives consisting of internal deletions or lacking amino- or carboxy-terminal

198 A series of LasR molecules containing internal deletions or substitutions in single, conserved

199 xpress Env proteins with serial truncations, internal deletions, or amino acid substitutions in the c

200 The altered protein bearing an internal deletion (p.Asp191_Lys244delinsGlu; p105DeltaEx

201 fectious progeny production by RNAs with the internal deletions placed in the sequence context of the

202 degradation and turnover of this particular internal-deletion polypeptide.

203 bination with a telomeric pBR sequence; (ii) internal deletions, presumed to occur by recombination b

204 ear element sequences resulting in FHIT gene internal deletions, probably as a result of carcinogen-i

205 ve collection of N-terminal, C-terminal, and internal deletion proteins has been used to demarcate th

206 point mutations in the central region or an internal deletion removing most of this part of the prot

207 g point mutations in its initiation codon or internal deletions, respectively.

208 Truncations and internal deletions revealed a 26-amino acid targeting si

209 As patients with comparable in-frame internal deletions show relatively mild myopathic sympto

210 in whole animals, mice were prepared with an internal deletion that eliminated several activities of

211 gree of sequence identity and all contain an internal deletion that removes all of the pol gene and v

212 % of para transcripts are aberrant, owing to internal deletions that include the edited exon.

213 erlapping YACs, we were able to detect seven internal deletions that ranged from approximately 75 kbp

214 Furthermore, internal deletions that shorten the total length of the

215 transposon Ac can mutate to Ds by undergoing internal deletions, the mechanism by which these mutatio

216 derivatives containing 3' truncations and/or internal deletions to alkaline phosphatase and/or beta-g

217 Studies of mutant proteins with internal deletions upstream of the cleavage site in the

218 demonstrate two novel MDM2 transcripts with internal deletions, using RT-PCR followed by sequencing.

219 ion to full-length copies, a large number of internal deletion variants have been identified.

220 Evidence for mobility of internal deletion variants of other insertion sequences

221 A library of random internal deletion variants of S. typhimurium flagellin w

222 Amplicons with large internal deletions were excluded (<9 kb).

223 ree major classes of mutant substitutions or internal deletions were isolated that affect either the

224 nstructs involving N-terminal, C-terminal or internal deletions were remarkably stable, showing coope

225 f mutant forms of Drosophila Axin with large internal deletions when expressed at physiological level

226 n TSG101 transcript, shortened because of an internal deletion, which was expressed simultaneously wi

227 -DNA binding as a function of pH and (ii) an internal deletion within I1 increases Ultrabithorax-DNA

228 n lipomas, rearrangements of 6p21-23 produce internal deletions within HMGI(Y).

229 A series of internal deletions within intron 10 were tested for thei

230 We also generated internal deletions within the loop regions of GFP accord

231 l of expression of AGL15, a series of 5' and internal deletions within the regulatory regions of AGL1

232 ontrast, ABC DLBCL had a higher frequency of internal deletions within the switch mu (Smu) region com

233 Truncations or internal deletions within the VCD defined a 26-amino aci

234 ive interfering particles (DIPs) that harbor internal deletions within their genomes occur naturally