ライフサイエンスコーパス: internalize

1 nteract preferentially with arrestin-3 or to internalize.

2 anti-CD180 Ab, B cell receptors were rapidly internalized.

3 nsitization the tagged D2 receptors were not internalized.

4 They bind to cell membrane receptors and are internalized.

5 in peritoneal macrophages, despite not being internalized.

6 least to cells and so was not significantly internalized.

7 ane segmentation for probes that are rapidly internalized.

8 less of maternal mental health and offspring internalizing.

9 QT7 internalized 4- to 6-fold less than RN6390 with or witho

10 athrin-mediated endocytosis (CME) is used to internalize a diverse range of cargo proteins from the c

11 d human malaria parasite species secrete and internalize a lipocalin-like protein, PV5, to control he

12 The sequential conjugate was internalized about 13-fold more efficiently than the bra

13 g peptides (CPP) have the ability to rapidly internalize across biological membranes.

14 fuse rapidly throughout the axon surface and internalize after ligand-induced activation specifically

15 h which surface-expressed RSV F proteins are internalized after interaction with RSV-specific antibod

16 ndritic cells (MoDC) and show only LAMP-2 is internalized after ligation by specific Abs, including H

17 Once internalized, AimP reduces the expression of the negativ

18 ce quencher trypan blue to selectively image internalized alpha-syn seeds in cultured primary neurons

19 NK-92 cells do not internalize AML exosomes.

20 we show that human NK cells can efficiently internalize and degrade alpha-syn aggregates via the end

21 Cells that express oncogenic RAS are able to internalize and degrade extracellular protein via a flui

22 oodstream to sites of infection or injury to internalize and destroy microbes.

23 the receptor in a conformation that does not internalize and therefore does not undergo down-regulati

24 Terrestrial plants can internalize and translocate nanoparticles (NPs).

25 Dimercaptosuccinic acid-coated SPIONs are internalized and accumulate in late endosomes/lysosomes,

26 elatively small proportion of ferric iron is internalized and boosts production of iron-containing en

27 Type I IFN (IFN-I) is thought to be rapidly internalized and degraded following binding to its recep

28 unconjugated miR146a, C-miR146a was rapidly internalized and delivered to the cytoplasm of target my

29 zation exposure could mitigate risk for both internalized and externalized violence.

30 apidly adhered to human eosinophils and were internalized and inactivated (95% in <= 2 hours) as refl

31 rms a complex with the PTHR1 that is rapidly internalized and induces prolonged cAMP production from

32 Signaling receptors are internalized and regulated by clathrin-mediated endocyto

33 s into polycationic polymers, which are then internalized and retained by the cancer cells.

34 ronment, whereas heat-killed F. nucleatum is internalized and sequestered in the cancer cells.

35 rhodopsin mislocalized to the PM is actively internalized and transported to lysosomes where it is de

36 ed these with mRNA, and observed which cells internalized and/or expressed the mRNA over 72 h after i

37 atypical chemokine receptor 2 (ACKR2) binds, internalizes and degrades most proinflammatory CC-chemok

38 f LGR5, a wild-type form that constitutively internalizes and two mutant forms whose internalization

39 eak associations of SigmaLMW phthalates with internalizing and externalizing behaviors in adolescence

40 al extremes, exhibiting large differences in internalizing and externalizing behaviors relevant to mo

41 association between maternal ACEs and infant internalizing and externalizing behaviors.

42 pecific dimensions of psychopathology (i.e., internalizing and externalizing dimensions), a general p

43 ough which deprivation might confer risk for internalizing and externalizing psychopathology.

44 -order groupings such as those designated as internalizing and externalizing.

45 scales; however, it was associated with more internalizing and somatizing behaviors in boys, but not

46 confirmed a subset of particles to be fully internalized, and high-contrast ptychographic images sho

47 ACKR3 contributes to chemotaxis by binding, internalizing, and degrading the chemokines CXCL11 and C

48 ritical steps in this process, the export of internalized antigen to the cytosol, has been suggested

49 n cross-presentation, ERAD, and transport of internalized antigens into the cytosol.

50 ed pits (CCPs) that eventually pinch off and internalize as clathrin-coated vesicles.

51 ctivation is initiated, cell-surface SAG1 is internalized, associates with an apico-basally polarized

52 alian macrophages that are unable to degrade internalized bacteria also exhibit compromised NF-kappaB

53 ansporter ClC-b/CLCN7 delayed degradation of internalized bacteria.

54 We found that the internalized bacterial endotoxin lipopolysaccharide (LPS

55 halate (MBzP) was positively associated with internalizing behavior and relationship problems scores

56 Mothers reported on children's internalizing behavior problems at 24 months of age.

57 ms (externalizing behavior, temperament, and internalizing behavior).

58 halate (MnBP) was positively associated with internalizing behavior, relationship problem, and emotio

59 No associations were found with internalizing behavioral problems.

60 as been proposed to mediate the recycling of internalized beta(2)AR back to the cell membrane.

61 of CD13 resulted in aberrant trafficking of internalized beta1 integrin to late endosomes and its ul

62 uman mammary epithelial cells upregulate and internalize beta4-integrin along with its matrix substra

63 C surface for at least 2 h into G(1) and was internalized by 4 h without heparin and within 1 h with

64 cRGDyK-guided liposomes were preferentially internalized by activated HSCs in vitro and in vivo, and

65 Endocytosis analysis revealed that MOFs are internalized by active transport and that inhibiting the

66 EVs from older individuals were more readily internalized by B cells and increased MHC-II expression

67 nthetic vesicles, or polymersomes, which are internalized by binding to scavenger receptors and subse

68 displace CD80 from the surface of APCs to be internalized by breast cancer cells.

69 , we observe that the microresonators remain internalized by cells during cell division, which enable

70 ated the Hex nanocarrier that is efficiently internalized by cells without cytotoxicity.

71 oth 30- and 90-nm-diameter AgNWs are readily internalized by cells, but thinner NWs are mechanically

72 S. aureus is internalized by Cftr-deficient macrophages in the lung,

73 poly(lactide-coglycolide) nanoparticles were internalized by circulating monocytes and neutrophils, r

74 he mouse nasopharynx and to adhere to and be internalized by cultured human epithelial cells and rest

75 tered by autophagy or extracellular material internalized by endocytosis and phagocytosis.

76 (BCR) cluster on the plasma membrane and are internalized by endocytosis.

77 to ischemic hindlimbs, were most efficiently internalized by endothelial cells relative to smooth mus

78 Moreover, they were internalized by endothelial cells, thus supporting their

79 beled analogs of GalNAc-conjugated PNAs were internalized by HepG2 cells that express the ASGPR but w

80 These EVs get internalized by human microglial cells, and miR-148a sup

81 posomes specifically bound to CD169 and were internalized by in vitro-generated monocyte-derived DCs

82 hat extracellular post-abscission MBs can be internalized by interphase cells, where they reside in t

83 ly-labelled LAAO was efficiently and rapidly internalized by keratinocytes, suggesting that catalysis

84 cessed ADAMTS9 bound heparan sulfate and was internalized by LRP1, LRP2 and clathrin-mediated endocyt

85 eri, the causative agent of Lyme disease, is internalized by macrophages and processed in phagolysoso

86 NETs were internalized by macrophages, and removal of the protein

87 Finally, polar SNO-OCTs are rapidly internalized by mammalian cells and remain functional in

88 st plasma membrane into protrusions that are internalized by neighboring cells.

89 rom macrophages both free and in EVs, and is internalized by neurons.

90 d that PLT-derived EVs were more efficiently internalized by PC-3 cells than RBC-derived EVs.

91 hment to cell surface receptors, reovirus is internalized by receptor-mediated endocytosis.

92 xosomes and shed microvesicles (MVs), can be internalized by recipient cells to modulate function.

93 Thus, specific cargoes are internalized by ROCK2-mediated activation of myosin II i

94 he cysteine protease inhibitor cystatin C is internalized by some cancer cells, which affects cellula

95 and further our understanding of how EVs are internalized by target cells to allow cross-talk between

96 folding a higher amount of nanoparticles was internalized by the cells and, therefore, results were o

97 It is internalized by these fungi, but uses spatially distinct

98 ped (D)VAP-liposomes/MTI-31 were efficiently internalized by U87 cells and consequently showed a pote

99 cted, particles with cyclic RGD were heavily internalized by U87MG (proportional to the peptide conte

100 Golgi complex for cell invasion, but not for internalized cell degradation.

101 The internalized cell was shown to be degraded due to the ly

102 Trans-internalized Celsr1 carries with it additional core PCP

103 ost, scalable solution to producing lasting, internalized change in adolescents' dietary attitudes an

104 These internalized coat proteins are the most asymmetrically a

105 Rs continue to signal through G protein from internalized compartments, mediated by a GPCR-G protein-

106 In the second pattern, seen in the internalizing conditions of major depression and anxiety

107 for antidepressant medications in pediatric internalizing conditions.

108 For example, CXCR4 does not internalize constitutively.

109 nslationally modify a macromolecule, such as internalized CuMbn or its uncharacterized partner protei

110 uch as aripiprazole, are less efficacious in internalizing D2R than most of the antiparkinsonian agen

111 classic recycling endosomes, suggesting that internalized DAT targets to either degradation or an und

112 a clump in dead cells, and macrophages which internalized dead infected cells were very likely to die

113 ch we call lysosome-rich enterocytes (LREs), internalize dietary protein via receptor-mediated and fl

114 Complementary assessment of internalizing disorders and brain imaging in children su

115 Internalizing disorders such as anxiety and depression a

116 dsRNA transporter and is required to traffic internalized dsRNA from endocytic compartments into the

117 VE 1-ASSOCIATED KINASE 1 (BAK1) complex, and internalized dynamically into endocytic compartments.

118 Internalized EETI-II subsequently accumulates in intrace

119 used to distinguish between cell-surface and internalized EGFR on the basis of the addition of red or

120 imal branched actin network is sufficient to internalize endocytic pits against membrane tension.

121 These subsets varied in their ability to internalize Escherichia coli, Staphylococcus aureus, and

122 Na(+), the primary cationic osmolyte internalized, exited endocytic vacuoles via two-pore cha

123 Competence allows bacteria to internalize exogenous DNA fragments for the acquisition

124 or-that accounts for shared variation across internalizing, externalizing, and thought disorders in d

125 -1 ortholog, SIDT2, is required to transport internalized extracellular dsRNA from endocytic compartm

126 By internalizing extracellular protein and targeting it for

127 here were no independent associations of the internalizing factor or any individual psychiatric disor

128 Elevated scores on the common internalizing factor, with high loadings across anxiety

129 Failure to resolve internalized fluid impairs the tissue surveillance activ

130 for processing images acquired with rapidly internalized fluorescent probes.

131 Our data indicate that a large fraction of internalized fluorescent tRNA (>70%) appears to diffuse

132 that, in response to TGF-beta, cell surface-internalized FN is not degraded by the lysosome but inst

133 8)F]FGlc-FAPI showed specific uptake, a high internalized fraction, and low cellular efflux.

134 sity parameters, automatically discriminates internalized from external targets, and stores the relat

135 structural basis for GPCR-mediated sustained internalized G protein signaling.

136 microscopy image of a cancer cell containing internalized GNPs.

137 stin in HEK293 cells, and nearly half of the internalized GPR15 receptors were recycled to the plasma

138 Internalized GPRC6A was mainly co-localized with the ear

139 stigated by assessing the co-localization of internalized GPRC6A with selected Rab protein markers.

140 tonomous pathway in which a growth factor is internalized, has its localization regulated by phosphor

141 An internalized helical needle projects from the NC and bac

142 Neurons internalized His-CATB, an effect that was partially decr

143 macrophage-conditioned media differentially internalized His-CATB, dependent on the HIV replication

144 Certain norms are internalized (i.e., acting according to a norm becomes a

145 on was also a specific risk factor for adult internalizing (i.e., anxiety and depression, beta = 0.20

146 Surprisingly, whereas Fz6 and Vangl2 both internalize in trans, Vangl2 proteins intrinsic to the d

147 Here, we report that CS causes CFTR to be internalized in a clathrin/dynamin-dependent fashion.

148 and attachment (G) protein were found to be internalized in both infected and transfected cells afte

149 re the major toxicity driver; however, AgNPs internalized in food vacuoles contributed to the perturb

150 hat whereas smaller monodisperse objects are internalized in greater numbers, objects of different si

151 The viruses were internalized in small endocytic pits that led the virus

152 ated a high drug loading efficiency and were internalized in the cytoplasm of CF cells.

153 Hu11B6 is a monoclonal antibody that internalizes in cells expressing androgen receptor (AR)-

154 which is expressed at the cell membrane and internalizes in response to ligand activation by testost

155 quent preterm behavioral phenotype symptoms (internalizing, inattention, and social deficits) in very

156 stin2 at the plasma membrane and efficiently internalize into endosomes upon AngII stimulation.

157 ng peptide (CPP) that is able to efficiently internalize into human cells.

158 A nanoparticles as they selectively bind and internalize into liver cancer cells.

159 nverts to a crystal hydrate, water molecules internalize into the crystal structure resulting in diff

160 neuron-specific miR-124-3p, are potentially internalized into astrocytes.

161 ly, EVs secreted from PKM2-null T cells were internalized into B cells and markedly inhibited B-cell

162 ted that the cystine-knot peptide EETI-II is internalized into cells and that its cellular uptake cou

163 nked oligolysine coats are non-toxic and are internalized into cells more readily than non-cross-link

164 cytosine-rich stick ends (C-monomer) and are internalized into cells through lysosomal pathway.

165 gainst bacteria incorporated in a biofilm or internalized into cells without harming human osteoblast

166 We also found that PM-bound OlyA was rapidly internalized into cells, whereas PM-bound ALOD4 remained

167 o cells by receptor-mediated endocytosis and internalized into endolysosomes.

168 ized on the RMC surface at G(0)/G(1) and was internalized into G(1) cells under normal glucose condit

169 Here we demonstrate that the Tkv receptor is internalized into hub cells from the MT-nanotube surface

170 -resistant Staphylococcus aureus strain were internalized into human macrophages in vitro and that th

171 Bacteria internalized into osteoblasts were reduced by the AMP.

172 These muropeptides are internalized into the cytoplasm and bind to the transcri

173 Instead, H84T is internalized into the late endosomal/lysosomal compartme

174 As a result, at lower flake sizes GO rapidly internalizes into HeLa cells with the following 70% fluo

175 ed capacity of Tfr1-deficient hepatocytes to internalize iron from transferrin.

176 echanism by which extracellular vesicles are internalized is incompletely characterized, it is genera

177 s efficiently; however, when P. stomatis was internalized, it was promptly eradicated.

178 Botulinum neurotoxin (BoNT) binds to and internalizes its light chain into presynaptic compartmen

179 increased release in the medium of the bound/internalized LDL, as compared with LDLR-WT.

180 learning, and that they are grounded also in internalized linguistic and social interaction.

181 ells (MSCs) express scavenger receptors that internalize lipids, including oxidized low-density lipop

182 bserved that cultured lung fibroblasts could internalize live NTHi.

183 ement activation, IFN-gamma-primed human ECs internalize MAC, triggering both endosomal-associated NI

184 In human EC cultures, internalized MAC also causes NLRP3 (NOD-like receptor fa

185 Internalized MAC stabilize NIK (NF-kappaB [nuclear facto

186 LRP1 binds and internalizes many plasma components, playing multiple cr

187 he primary mechanism eukaryotic cells use to internalize material.

188 res; and (b) individual-level (exposures and internalized) measures, including explicit self-report,

189 -rich sub-compartments is demonstrated as an internalized mechanism for activating protocell buoyancy

190 tosis, in which SVs are regenerated from the internalized membrane and synaptic endosomes.

191 ormula: see text] signals in LECs suggesting internalized metabolites and metabolic exchange between

192 s of redispatch by $1.1B-$1.4B, (4) although internalizing methane leakage, climate damages, and heal

193 transforming external events into predictive internalized models of the world.

194 Internalized MOG colocalized with autophagosomes, which

195 upon polymer structure-longer polymers were internalized more rapidly and more efficiently than were

196 nt efferocytosis, phagocytes must be able to internalize multiple ACs.

197 a variable-order Markov model that learns by internalizing n-grams from training sequences.

198 This complex reacts with internalized NO with a bimolecular rate constant of 10(1

199 Humans' capacity to internalize norms likely evolved in our ancestors to sim

200 Evolving the ability to internalize norms was likely a crucial step on the path

201 To internalize nutrients and cell surface receptors via cla

202 MRGPRX2 was rapidly internalized on codeine binding in a beta-arrestin-1-dep

203 ced at the phagosomal compartment toward the internalized parasite via NOX-2 (gp91-phox) activation.

204 icantly decreased O(2) (*-) detection in the internalized parasite.

205 s at different focal planes show evidence of internalized particles and suggest insights into protein

206 yses revealed that the size distributions of internalized particles differed between the NPs and BPs

207 th a focus on the response of macrophages to internalized pathogens and concentrating on Mycobacteriu

208 Consistently, annexin A2 and a cell-internalizing, penetratin-fused version of the selected

209 that macrophages were the primary cells that internalized PLN in the tumor microenvironment and that

210 Macrophages bind and internalize polyphosphates, in which their effects are i

211 3 (95% CI: -1.11, -0.16) points reduction in internalizing problems that was reflected in tendency to

212 eceptors (CRFr1, CRFr2) and the CRF receptor internalizing protein, beta-arrestin2 (Arrb2).

213 Remarkably, internalized proteins aligned with the applied voltage b

214 e MHC-I complexes with peptides derived from internalized proteins, a process called cross-presentati

215 te lysosomal processing as the major fate of internalized proteopathic seeds, and suggest lysosomal i

216 evant for the etiology of sex differences in internalizing psychiatric disorders, which are more prev

217 on-introversion and grouped neuroticism with internalizing psychopathology (e.g., depression or anxie

218 adolescence moderated higher levels of adult internalizing psychopathology among behaviorally inhibit

219 ing anxious phenotypes to the development of internalizing psychopathology and set the stage for deve

220 r), excess endosomal F-actin and trapping of internalized receptors.

221 We show that specialized phagocytes that internalize red blood cells develop in Toll-like recepto

222 s collected at the CFE due to the release of internalized redox molecules from translocating liposome

223 Perceptual grouping is believed to reflect internalized regularities of the natural environment, ye

224 t resources externally, private-metabolizers internalize resources before digestion, and cheats avoid

225 n M2 phenotype, they also restrict growth of internalized S. aureus through reactive oxygen species (

226 All subsets were more efficient at internalizing S. aureus and B. anthracis compared with E

227 ta-arrestin recruitment is required to fully internalize S1P1 receptors, the potency in inducing G al

228 the brain while simultaneously secreting and internalizing scores of proteins and lipids to maintain

229 If the SEP moiety has been internalized, SEP will remain fluorescent even during ap

230 ycoGag interacts with Ser5 in live cells and internalizes Ser5 via receptor-mediated endocytosis.

231 Internalized Siglec-8 localized to the lysosomal compart

232 nt component of the inflammatory milieu, PKA internalizes Slack channels from the DRG membrane, reduc

233 Both Cys(2)-ADAPT6 and Cys(59)-ADAPT6 were internalized slowly by HER2-expressing cancer cells.

234 At low concentrations of antigen, B cells internalize small BCR clusters by classical clathrin-med

235 calization and molecular interactions of the internalized SpaPQR 'export apparatus' complex, which is

236 doxorubicin, and we show that the conjugate internalizes specifically into PSMA(+) cells, where the

237 Identification of biologically grounded internalizing subtypes may assist in targeting early int

238 Ca(2+) influx that stimulates the return of internalized SUMO-PKD2 channels to the plasma membrane.

239 2+) influx leads to lysosomal degradation of internalized SUMO-PKD2 protein, which reduces surface ch

240 Higher ratings for externalizing and internalizing symptoms at baseline predicted smaller inc

241 uring cognitive reappraisal-buffers risk for internalizing symptoms following exposure to adversity.

242 maternal cortisol was associated with higher internalizing symptoms in girls only, and this associati

243 ied pathway from maternal cortisol to higher internalizing symptoms in girls via alterations in neona

244 We used bifactor modeling of internalizing symptoms to separate symptom variance comm

245 obiological heterogeneity within youths with internalizing symptoms using structural data collected a

246 g for family history of psychotic disorders, internalizing symptoms, and cognitive performance.

247 ns of neurodevelopmental, externalizing, and internalizing symptoms, using structural equation modeli

248 we studied the role of ELMO1 in the fate of internalized targets.

249 y to respond to TCR-mediated stimulation and internalize TCRs mediates detection of ligand density or

250 Finally, internalized TCRs continued to signal and genetic modifi

251 ectively delayed proliferation in cells with internalized TCRs.

252 The lymphocytes internalize the MHC II-CD4 complexes in a phagocytosis-l

253 suggesting that the cognate BCR efficiently internalizes the Id in an IC with nucleosomes.

254 caudal end-that migrate towards one another, internalizing the endoderm until they meet at the yolk s

255 e cells suppress oHSV-1 growth in gliomas by internalizing the virus through phagocytosis.

256 To effectively capture and internalize their targets, these cups are organized into

257 diameter at their apical side, continuously internalizing their surrounding medium.

258 nostic families of disorders (externalizing, internalizing, thought disorder) exhibited highly overla

259 gliosides, both virion types are efficiently internalized through endocytosis, but capsids fail to un

260 EVs, are able to be internalized through integrins expressed in parental cel

261 ies, designed peptides specifically bind and internalize to EGFR overexpressing cells with three to f

262 and albumin were alike, but the former were internalized to a greater extent by the transferrin-rece

263 on the mature ComS pheromone (XIP), which is internalized to activate the (R)RNPP-type ComR sensor by

264 Our results demonstrated that HCV-exo internalized to HSC and increased the expression of prof

265 Following endocytosis, receptors that are internalized to sorting endosomes are sorted to differen

266 body was found on the surface of, as well as internalized to, bone marrow megakaryocytes.

267 ression on cancer cells and their ability to internalize together with the bound ligand.

268 ding in various cells, the beta1 integrin is internalized, traffics to early endosomes, and is return

269 Whereas the CME of constitutively internalized transferrin receptors is mainly dependent o

270 Endocytic recycling of internalized transmembrane proteins is essential for man

271 Elp1 was found to bind to internalized TrkA receptors in an NGF-dependent manner,

272 Peptide agonists of SSTR2 are rapidly internalized upon binding to the receptor and linking a

273 m by which cells sense their environment and internalize various nutrients, growth factors and signal

274 ropilin-1, thereby preventing degradation of internalized VEGFR2, prolonging downstream signal transd

275 Internalized vesicles display a strongly delayed and seq

276 The internalized vesicles, costained with Rab5, had AP2 depl

277 PS-ASOs are known to be internalized via a number of endocytotic pathways and ar

278 horbol ester stimulation of PLD were rapidly internalized via apparent nonvesicular pathways rather t

279 This protein complex is internalized via clathrin-mediated endocytosis and degra

280 acterial entry sites, where C. pneumoniae is internalized via EGFR-mediated endocytosis.

281 uristatin and saporin toxins are efficiently internalized via hCD22 resulting in killing of B-cell ly

282 Ser5 is internalized via receptor-mediated endocytosis and reloc

283 st peptide, BIDEN-AP which, when selectively internalized via receptor-mediated endocytosis, suppress

284 with the current diamidine drugs and are not internalized via the transporters used by diamidines.

285 Internalized virus remained capable of expressing report

286 d to be providing some logs in protection to internalized viruses during UV irradiation, which if not

287 parated by problem type (maladaptive groups; internalizing vs. externalizing problems) and behavioral

288 raction of surface proteins and CD25 is only internalized when co-localized with other proteins.

289 ound sites, but is promptly desensitized and internalized, which prevents excess congregation.

290 from extracellular matrix proteins, becoming internalized with CD63, which is necessary for virus pro

291 with over 90% of the surface-bound conjugate internalized within 4 h.

292 ns in the defense and treatment of pathogens internalized within endosomes.

293 ars to be the first report of reovirus being internalized within FLA and remaining infectious, provid

294 , often taking hours or days to become fully internalized within the cellular environment.

295 Nannochloropsis oceanica algal cells become internalized within the hyphae of the fungus Mortierella

296 ncircled area of membrane can be severed and internalized within the lumen as a fragment upon lipid b

297 added to cells, this fluorescent peptide is internalized within vesicular structures, including glyc

298 different sizes presented simultaneously are internalized without preferred size.

299 ethods indicated 2 highly stable subtypes of internalizing youths (adjusted Rand index = 0.66; permut

300 We identified 2 subtypes of internalizing youths differentiated by abnormalities in