ライフサイエンスコーパス: interrogate

1 ext of the biological protein receptors they interrogate.

2 iagnosis and thus are not often biologically interrogated.

3 lthy controls mostly of US origin, were also interrogated.

4 er properties of the droplets were optically interrogated.

5 y randomising eight active-site residues and interrogating ~250,000,000 reconfigured variants.

6 lyzed by targeted next-generation sequencing interrogating 37 DNA damage-repair-associated genes.

7 HiChIP is a powerful tool to interrogate 3D chromatin organization.

8 ssue and single-cell assays, we functionally interrogated 51 TNNT2 variants, including 30 pathogenic/

9 unique pairs of genetic alterations that we interrogated, 9 were able to induce HCC.

10 We interrogate a (88)Sr(+) ion with our stimulated Brilloui

11 When allowed to interrogate a diverse range of in vivo pathogens infecti

12 This allowed us to rapidly interrogate a number of MCAK/Kif2C motor domain mutation

13 entation, and high read counts to accurately interrogate A-to-I editing sites.

14 We investigated initially by interrogating a novel synonymous UPF3B variant in a male

15 Assessment of 136 VUSs interrogating a range of PALB2 biological functions resu

16 rs to progress and emerging clinical reports interrogating acquired resistance with the goal to facil

17 nd relevant genomic features can be visually interrogated across up to sixteen multiple association d

18 e, we employed single-cell RNA-sequencing to interrogate aging-related changes in the HFSCs.

19 e imaging seems promising to non-intrusively interrogate AKI-related biomarkers, the low kidney contr

20 quencing for studies of human genetics is to interrogate all forms of variation, including single-nuc

21 sive, and typically does not comprehensively interrogate all relevant signaling pathways.

22 presented approach is label-free and permits interrogating an analyte by hundreds of different ligand

23 hput analysis is promising to systematically interrogate and perturb aberrant mechanobiology, which c

24 ence compounds suggest many could be used to interrogate and perturb mitochondrial biology to validat

25 and engineering systems that are capable of interrogating and stimulating neural pathways, from sing

26 h in the use of bioinformatics as a means of interrogating antibody variable gene repertoires.

27 ghts the utility of PhIP-Seq for extensively interrogating antigenic repertoires in human autoimmunit

28 ow being used to systematically document and interrogate astrocyte biology in vivo.

29 traits and plasma metabolomic profiles were interrogated at 2- and 4-weeks post-transplantation.

30 Here we use single cell-RNA sequencing to interrogate basal stem cell heterogeneity of human inter

31 ders and four neurodegenerative disorders to interrogate biological pathways, developmental windows a

32 ave become very powerful in their ability to interrogate biological processes.

33 irst application of synchrotron RE-AFM-IR to interrogate biological soft matter at the subcellular le

34 This review focuses on interrogating biomarkers of prostate cancer progression,

35 orthogonal chemistries enable researchers to interrogate biomolecules in living systems.

36 By interrogating both the mutagenized epithelium and its mi

37 Here, we establish a new paradigm for interrogating brain-periphery interactions by leveraging

38 Genome-wide association studies (GWAS) have interrogated breast cancer survival but often are underp

39 The areas of different thickness can be interrogated by a single reflection probe placed on a fi

40 -reduced radical ions which are subsequently interrogated by collisional activation.

41 ar and intracellular signaling, which can be interrogated by macroscopic and microscopic optical imag

42 model representing 29 unique host genotypes, interrogated by microbiome sequencing and targeted micro

43 Gene and compound functions are often interrogated by perturbation.

44 tive fibre ring cavity with optical gain and interrogated by the OFDR system for 11 cycles with a sin

45 es in their catalytically active form can be interrogated by using probes targeted toward individual

46 o characterize this evolutionary process, we interrogated, by whole genome sequencing, 25 samples col

47 otent C3aR antagonists are now available for interrogating C3a receptor activation and suppressing C3

48 Finally, we assign and experimentally interrogate cancer-associated hot-spot mutations localiz

49 have been identified through these efforts, interrogating cancer genomes has also shed new light on

50 tocompatibility complex class I tetramer, we interrogated CD8(+) T cell responses during CHIKV infect

51 The emergence of genome-wide analyses to interrogate cellular DNA, RNA, and protein content has r

52 alteration in the RPS25 knockout, we closely interrogated cellular phenotypes.

53 SEEM deuterium accessibility measurements to interrogate channel structure within lipids, in which bo

54 To interrogate CK5 interacting proteins that may be functio

55 ower of large-scale blood cell trait GWAS to interrogate clinically meaningful variants across a wide

56 es require multiplexed gene perturbations to interrogate combinations of genes and resolve physiologi

57 on the use of degraders as research tools to interrogate complex biological problems.

58 Here, using single-cell technology, we interrogate complex patterning defects and define a Hedg

59 High throughput screening (HTS) interrogates compound libraries to find those that are "

60 sed RNA-sequencing approach was developed to interrogate decitabine-induced transcriptome changes in

61 Overall, bioPROTACs are powerful tools for interrogating degradation approaches, target biology, an

62 on fate maps and discuss their potential for interrogating development at new depths.

63 We used miRNA PCR arrays to interrogate differences in serum miRNAs using two rat mo

64 n combination with novel analysis methods to interrogate different aspects of the functional readout

65 We apply PIC-seq to interrogate diverse interactions including immune-epithe

66 ase (RT) enzymes are indispensable tools for interrogating diverse aspects of RNA metabolism and tran

67 es illustrate the importance of functionally interrogating diverse tumour phenotypes driven by indivi

68 g to determine a 2.3 angstrom structure, and interrogate dynamics, of secretin bound to the SecR:Gs c

69 approach allows TCR/pMHC interactions to be interrogated easily at large scale.

70 This approach will be valuable for interrogating effects of cannabis and delineating neural

71 rmed by relatively few neurons, which can be interrogated efficiently, revealing fundamental principl

72 to optical measurements also simultaneously interrogated electrochemically (EC).

73 ectly in the browser for the structure being interrogated enabling their rapid inspection.

74 tibility complex (MHC) class II tetramers to interrogate endogenous, Salmonella-specific CD4(+) helpe

75 pigenetic editing provides opportunities for interrogating enhancer function in native biological con

76 alues; it is often used as a genetic tool to interrogate essential genes.

77 with orientation discrimination training to interrogate experience-dependent plasticity across corti

78 he first time a specific pool of ceramide is interrogated for acute signaling functions, and the resu

79 sequencing data from child-parent trios were interrogated for de novo single-nucleotide variants/inde

80 Cord blood DNA samples from the infants were interrogated for genome-wide DNA methylation levels usin

81 The AR locus was interrogated for resistance-causing genomic modification

82 ee of the 12 single nucleotide polymorphisms interrogated for the SNX1 gene were associated with a de

83 Cas13d is an efficient knockdown platform to interrogate gene function in animal embryos.

84 dous potential for CRISPR screens to map and interrogate gene regulatory networks at unprecedented sp

85 TL to infer differential gene expression and interrogate gene set enrichment for the trait-associated

86 We, therefore, interrogated gene expression profiles of SLE synovium to

87 l for the development of similar methods for interrogating gene function in other marine invertebrate

88 e mixed model (CoMM) was proposed to jointly interrogate genome on complex traits by integrating both

89 Single-cell Hi-C (scHi-C) interrogates genome-wide chromatin interaction in indivi

90 To further interrogate genomic features of SDC, we have conducted m

91 ce anisotropy imaging of histone H2B-EGFP to interrogate global chromatin compaction changes in respo

92 r-Glyco makes it possible to comprehensively interrogate glycoproteomics data and illuminate the many

93 by using supertree and coalescent methods to interrogate >3,000 gene families in archaea and eukaryot

94 of fluorescence-based techniques to further interrogate hA(2A)AR pharmacology and signaling.

95 A-DRB1*01:01 and HLA-DRB1*03:01 molecules to interrogate high-density peptide arrays, in casu contain

96 ression testing and provides a framework for interrogating higher-order interactions using single-cel

97 populations provide a unique opportunity to interrogate host-microbe co-evolution and its impact on

98 Here, we further interrogate how the differentially spliced alpha repeat

99 arbon monoxide (CO) as a structural probe to interrogate how the functionalities of the two enzymes a

100 Sassen's influential book 'The Global City' interrogated how changes in the occupational structure a

101 This study provides a framework for interrogating how complex biological processes, such as

102 e provides a powerful approach with which to interrogate HSC self-renewal and lineage commitment and,

103 tients but also represent precision tools to interrogate human disease biology.

104 encing with in situ validation approaches to interrogate human intestinal development from 7-21 weeks

105 tion may thus provide a useful framework for interrogating hypnozoite biology.

106 tic inactivation in human cells, we directly interrogate if differences in the centromere length refl

107 -) mice, they may provide a valuable tool to interrogate IL-17F and IL-17AF function in vivo in other

108 A whole-blood assay was used to interrogate in vitro cytokine responses to heterologous

109 When interrogated in cranial neural crest cells, we identifie

110 Importantly, the biosensing response can be interrogated in real time.

111 ne YM is still understudied and has not been interrogated in the context of myocardial infarction (MI

112 we developed a mass spectrometric method to interrogate incorporation of selenium into proteins.

113 enous matrix (interfascicular matrix) can be interrogated independently.

114 igh-throughput assay exists for functionally interrogating individual isoforms.

115 ds for producing, maturing, and mechanically interrogating iPSC-derived cardiomyocytes, the initial r

116 ive cysteine profiling has been performed to interrogate itaconate's reactivity in cell lysates, but

117 nce, provides a novel platform with which to interrogate its functional significance in normative and

118 mical technique widely used by biologists to interrogate its physiology.

119 bus pallidus (GPe) undermines our ability to interrogate its precise behavioral and disease involveme

120 nism, thus providing a unifying framework to interrogate joint patterning in the tetrapod limb.

121 ight on technologies that will be crucial to interrogate key questions in chromatin and chromosome bi

122 This model therefore provides a framework to interrogate key requirements for robust chromosome biori

123 el system might provide new opportunities to interrogate LA biochemistry, biology, and physiology.

124 and reduces the time and resources needed to interrogate large datasets.

125 ffer from heterogeneous sampling errors when interrogating large burn areas.

126 e generation of a mutant U8 animal model for interrogating LCC-associated pathology.

127 ed laser photostimulation circuit mapping to interrogate local LCIC circuits in adult mice of both se

128 Here we interrogate LOH of polymorphisms in essential genes as a

129 ar, ASOs are frequently used to functionally interrogate long noncoding RNAs (lncRNAs) and discrimina

130 Future studies should interrogate longer durations of decolonization and/or de

131 provides a powerful means to quantitatively interrogate macromolecule synthesis in heterogenous tiss

132 tomic systems, which use optical lattices to interrogate many thousands of atoms in parallel(11,12).

133 ce in sensory and motor circuits that can be interrogated mechanistically.

134 Our study aimed to interrogate microRNA (miRNA) and metabolites, two biomol

135 e a chemical imaging strategy to selectively interrogate minor, subcellular pools of enzymatic activi

136 Here we biochemically and functionally interrogate modes of ARF-DNA interaction.

137 f advanced characterization tools, which can interrogate MOFs under realistic synthesis as well as ca

138 ween multiple states although our ability to interrogate, monitor and visualize them is limited by a

139 ansion Microscopy (miriEx) to simultaneously interrogate morphology, molecular markers, and connectiv

140 Using a high-throughput technology to interrogate most single transmembrane receptors for bind

141 archers can construct tailor-made probes for interrogating multivalent interactions with angstromngst

142 erefore, an orthogonal series of experiments interrogated MYC's effect on the expression of synthetic

143 y our studies demonstrate that modifying and interrogating native chromatin with chemical precision i

144 This study functionally interrogated nine PLCG1 mutations (p.R48W, p.S312L, p.D3

145 udies had small samples (all <60, most <20), interrogated only a small fraction of the brain, and avo

146 ed in vivo on mutant animals, allowing us to interrogate organism-level phenotypes.

147 ips extracted from this study can be used to interrogate other diseases, microbes, and mechanisms.

148 We interrogated our model by investigating changes in the c

149 ring other UPF3B mutations, permitting us to interrogate pathogenic mechanisms of UPF3B-associated ND

150 combining in silico and in vitro methods to interrogate patients' T cells specificity.

151 er-Lys(4), and the role of ERK signaling was interrogated pharmacologically with MEK1/2 inhibitor U01

152 To interrogate phenotype dynamics of circulating immune cel

153 This chemical biology approach allows to interrogate phenotypes that tend to be overlooked by oth

154 comprehensively classify human HCs ex vivo, interrogate phenotypic plasticity, and characterize anti

155 To interrogate possible functions of this specific pool of

156 trometry (MS) is a widely used technique for interrogating protein structure and dynamics.

157 CE-2-correlated gene signatures were used to interrogate publicly available databases to identify ups

158 We interrogated purified sorted tumor fractions from these

159 ded Ribo-Keima(5) and Ribo-Halo reporters to interrogate r-protein homeostasis with and without activ

160 dying heart development have been applied to interrogating regeneration of the diseased heart, exempl

161 and substantia nigra from 117 human brains, interrogating regulation at different RNA processing sta

162 rve marker (anti-mullerian hormone [AMH)] to interrogate reproductive aging patterns and associated f

163 itivity, rapid analysis time, and ability to interrogate sample complexity or heterogeneity and the a

164 tes the power of an ensemble perspective for interrogating sequence-function relationships.

165 photothermal heterodyne imaging (IR-PHI) to interrogate single, high aspect ratio Au nanowires (NWs)

166 Here, we systematically interrogated somatic mutations involved in immune signal

167 unoprecipitation (eCLIP) of desired RBPs, we interrogate specific RNA-protein complexes, such as hist

168 cific" STAT3 inhibitor that is often used to interrogate STAT3-mediated gene expression in vitro and

169 e power of monoclonal antibodies as tools to interrogate structure-function relationships of assembly

170 preclinical utility of this murine model to interrogate subtype-specific differences in amplified-HE

171 her core cellular systems and experimentally interrogating such systems in organisms from all major l

172 robustness, and precision of this method to interrogate SV contents will facilitate novel insights i

173 loyed a targeted pharmacological approach to interrogate synaptic mechanisms recruited by HA signalin

174 campal synapses and therefore can be used to interrogate synaptic properties.

175 rface-enhanced Raman spectroscopy (SERS) can interrogate systems by directly fingerprinting their com

176 directed against human signaling proteins to interrogate the activation status of host erythrocyte ph

177 tilizes exonuclease III and exonuclease I to interrogate the binding properties of small-molecule-bin

178 tes an excellent in vitro tool with which to interrogate the biology of IRAK3.

179 er-based proteomics technology (SOMAscan) to interrogate the blood proteome of age- and sex-matched p

180 ols that can form seamless biointerfaces and interrogate the brain with unprecedented resolution.

181 model, our method allowed us to analyze and interrogate the cardiac microvasculature and the tissue

182 high-dimensional mass cytometry analysis to interrogate the cellular interactions that are associate

183 ng, optogenetic and behavioral approaches to interrogate the circuit mechanisms by which VLM(CA) neur

184 ction, we used bulk RNA-seq and scRNA-seq to interrogate the developing human intestine, lung, and ki

185 Several experimental techniques interrogate the effects of environmental exposure on the

186 well-established gene regulatory network to interrogate the embryo using single cell RNA sequencing.

187 iptional program from regulation by SOX2, we interrogate the expression of newly-identified tracheal

188 k and visible absorption spectroscopies that interrogate the FC state of rigorously diamagnetic [M(bp

189 echanical model with multiple cell layers to interrogate the flattening of organs during development.

190 A comprehensive platform is needed to interrogate the full small RNA'ome, a prerequisite for d

191 To interrogate the function of autoreactive CD4(+) T cells

192 iting has transformed our ability to rapidly interrogate the functional impact of somatic mutations i

193 terium exchange kinetics with MS (HDX-MS) to interrogate the high-order structure of proteins is now

194 losis (TB) and demonstrated its potential to interrogate the host-pathogen interaction (Tezera et al.

195 Therefore, to interrogate the immune impact of radiation on the tumor

196 of DNA synthesis at all STR permutations and interrogate the impact of STR sequence and secondary str

197 roarrays and cytokine profiling were used to interrogate the impact of the Lactobacillus rhamnosus R0

198 DNA origami nanoparticles to systematically interrogate the impact of these nanoscale parameters on

199 Here, we interrogate the importance of CenDNA in centromere speci

200 In the current study, we sought to interrogate the influence of the pregnane X receptor (PX

201 he value of lignin modification as a tool to interrogate the informational content of plant cell wall

202 Here, using a co-culture system to interrogate the interaction between melanocyte dendrites

203 In this study, we extend these concepts to interrogate the interdependence of cell type- and stimul

204 In the current study, we interrogate the intersection of TLR4 signaling, epitheli

205 sis tools that can be used to simultaneously interrogate the lineage and transcriptomic information o

206 uted system with a defined set of signals to interrogate the mechanism of SIRPA activation and its do

207 toni and performed a suite of experiments to interrogate the mechanistic basis of social dominance.

208 Herein, nLC-MS/MS was used to interrogate the mitochondria-enriched proteome of heart

209 we applied atomic force microscopy(7-12) to interrogate the morphologically distinct Staphylococcus

210 alamic cold sensor and a molecular marker to interrogate the neuronal circuitry underlying thermoregu

211 Single-particle tracking offers a method to interrogate the organization of transmembrane proteins b

212 over a novel role for 2-pyridone ligands and interrogate the origin of enantioselectivity in the (+)-

213 ically recommended guidelines to collect and interrogate the pathogenicity of 44 USP9X variants assoc

214 ophageal adenocarcinoma (EAC) prompted us to interrogate the pattern and timing of metastatic spread.

215 he classical monocyte surface proteome, then interrogate the phenotypic differences between each mono

216 quencing and ribosome footprint profiling to interrogate the platelet transcriptome and translatome i

217 ell-active chemical tool that can be used to interrogate the poorly characterized function(s) of BRSK

218 ps and use a population genomic framework to interrogate the probable mode and tempo of cognitive evo

219 sed single-cell RNA sequencing (sRNA-seq) to interrogate the rare CD34(+) progenitor and the more dif

220 manipulation and pharmacologic inhibition-to interrogate the role of 12-LOX in pancreatic development

221 To interrogate the role of chemosensation in the migration

222 o map the client binding site(s) on SurA and interrogate the role of conformational dynamics in OMP r

223 chromosome conformation enhancer capture to interrogate the role of enhancer-to-enhancer interaction

224 We investigated KIR-allelic polymorphism to interrogate the role of NK cells in PD.

225 the NMR and ESR detectors are concentric and interrogate the same sample volume.

226 Small RNA-Seq is a common means to interrogate the small RNA'ome or the full spectrum of sm

227 We interrogate the soil MCP concept by investigating the as

228 Here, we interrogate the striking correlation of FOA with retrotr

229 Here we interrogate the structurally dense (1.64 mcbits/ angstro

230 ered by a lack of antigen-specific models to interrogate the T cell response.

231 and as a broadly applicable cellular tool to interrogate the temporal and spatial dynamics of CDN sig

232 eneration Sequencing (NGS) assay, XACTLY, to interrogate the termini of fragmented DNA, information t

233 pectrometry (XL-MS) and molecular docking to interrogate the three-dimensional architecture of the MS

234 Here, we interrogate the tumor microenvironment at single-cell re

235 To interrogate the underlying cause of adipose tissue dysfu

236 Using NicE-viewSeq, we interrogated the accessibility of chromatin in a cell cy

237 We interrogated the complexity of serum using multiple comp

238 We also interrogated the contribution of each HIF isoform by con

239 s in animals with similar genotypes, we then interrogated the D1-MSN specific translatome associated

240 ng oncogenic drivers, here we systematically interrogated the dependence of cancer cells on the BCL-2

241 We interrogated the dual functions of beta-catenin in relat

242 hysiological, and behavioral experiments, we interrogated the effects of short interfering RNA-mediat

243 We interrogated the electronic health record (EHR) informat

244 We also interrogated the interaction between iron dose and vascu

245 esponse patterns of the T-PLL lymphocyte and interrogated the modulatory impact by TCL1A.

246 cells (PrSPCs) and drives transformation and interrogated the molecular mechanisms involved.

247 Here, we interrogated the roles of Brahma/SWI2-related gene 1 (BR

248 We interrogated the transcriptome, genome, proteome, and fu

249 We interrogated the well-described mechanism of MEK/ERK pat

250 fe, highlighting developmental research that interrogates the putative neurocircuitry of pediatric an

251 as of VPH cell types provides a resource for interrogating the circuit-level mechanisms underlying th

252 We also show that interrogating the conformational properties of the PRC7

253 The osteoclast offers a unique model for interrogating the contribution of co-regulated genes to

254 RI can serve as a practical imaging tool for interrogating the dopamine system in addiction.

255 we sought to reconcile these observations by interrogating the ECoG recordings of 18 presurgical huma

256 Interrogating the genome, especially locating critical c

257 as9-gRNA) find their targets by scanning and interrogating the genomic DNA for sequences complementar

258 Interrogating the impact of such 2D materials on health

259 By interrogating the lung transcriptome and proteome during

260 scriptomic resource provides a blueprint for interrogating the molecular and cellular basis of Alzhei

261 ated proteins have opened up new windows for interrogating the molecular mechanisms of mitochondrial

262 Interrogating the plasmon-driven processes over a wide r

263 By interrogating the proteomic composition of telomeres, we

264 In further interrogating the saturable targets of FIPC-1, we identi

265 logies, the advent of single-cell Hi-C makes interrogating the spatial structure of chromatin at sing

266 ptical tweezers provides a powerful means of interrogating the structure and folding of proteins.

267 Interrogating the TransComp-R models revealed activated

268 opment of a facile high-throughput screen to interrogate their activity.

269 ent a workflow to rapidly isolate SVs and to interrogate their metabolic contents at high-resolution

270 late, stimulate, and inhibit RFRP neurons to interrogate their physiological roles in the regulation

271 e medicinal chemistry programs being used to interrogate them, the challenges these programs face, an

272 ico signaling, establishing a new testbed to interrogate theoretical principles when internal cell dy

273 sequence features for protein variants; (2) interrogate these explainable gene-level variants for th

274 Here, we develop imaging tools to interrogate these functions in adult lateral ventricle C

275 To interrogate these roles, single-cell RNA sequencing (scR

276 We then interrogated these connectomic differences to determine

277 stication, and review the wealth of new data interrogating these predictions in crops.

278 n situ methods now provide an opportunity to interrogate this complexity at unprecedented resolution.

279 To interrogate this functional dichotomy, the intracellular

280 TGFbeta receptor I (ALK5) knockout mice, we interrogate this mechanism.

281 would provide the ability to mechanistically interrogate this network in preclinical models of neurop

282 Interrogating this region revealed that relatively small

283 Our human pancreas cell atlas can be interrogated to understand pancreatic cell biology and p

284 ns of all the components of metabolism to be interrogated together.

285 Here, we interrogate transcriptome data from primary breast tumor

286 to improve the accuracy of tumor detection, interrogate tumor heterogeneity, monitor treatment respo

287 FAS AT, FabD, and its cognate ACP, AcpP, to interrogate type II FAS ACP-AT interactions.

288 uring T. brucei development and the first to interrogate U-indel editing in EMF and MCF life cycle st

289 These constructs were interrogated using nuclear magnetic resonance, electroph

290 Coronary growth and function were interrogated using pressure-flow relationships, an episo

291 DNA from whole blood was interrogated using the MethylationEPIC or HumanMethylati

292 level of detail, and provides a platform to interrogate various aspects of translation that are diff

293 arbonyl bond and deuterium-labeled probes to interrogate various metabolic activities in cells, small

294 cattering-level multiplexing arrangement and interrogated via optical backscattered reflectometry, to

295 ation status of key immune synapse genes was interrogated, we observed disproportionately hypermethyl

296 To interrogate whether structures observed in vitro were al

297 e at far higher resolution than is typically interrogated, which is defined by the precise identity a

298 n human adult ventricular cardiomyocytes and interrogated whole genome transcriptional responses.

299 Imaging data from the three groups were interrogated with ANOVA and Kruskal-Wallis tests correct

300 evelopmental regulatory elements that can be interrogated with species-matching pluripotent stem cell