ライフサイエンスコーパス: interrogation

1 l fixation, precluding subsequent functional interrogation.

2 e capable of learning, memory and electrical interrogation.

3 at this prediction deserves serious clinical interrogation.

4 requirement for development needs empirical interrogation.

5 ce Ca(2+) recordings, for all-optical neural interrogation.

6 gy approaches particularly amenable to their interrogation.

7 y enable minimally invasive neuronal circuit interrogation.

8 a change in redox current upon voltammetric interrogation.

9 eaction can be performed prior to subsequent interrogation.

10 scale proteomic strategies rely on database interrogation.

11 on to the order of 5 x 10(-7) RIU in angular interrogation.

12 n resonance that require spectral or angular interrogation.

13 rocedures, clinic visits, and cardiac device interrogations.

14 work and provide an interactive web-tool for interrogations.

15 Electrochemical phase interrogation also offers improved insights into EAB sen

16 effective tool that supports unique digital interrogation and analysis of kidney tissue from animal

17 ated (optogenetic) switches for the targeted interrogation and control of cellular processes, includi

18 blockade and the compelling need for greater interrogation and data integration of both host and tumo

19 NA interactions and a rationale for mismatch interrogation and detection via DNA intercalation.

20 PR technology has opened a new era of genome interrogation and genome engineering.

21 of community ecology as a framework for the interrogation and interpretation of the human microbiome

22 encourage and facilitate further mechanistic interrogation and the development of PRMT-directed thera

23 resonance, and suggest novel approaches for interrogation and therapeutic manipulation of acquired f

24 emble duty cycles up to 96% through repeated interrogation, and frequency stability of 4.7 x 10(-16)

25 the neural tissue, recent advances in neural interrogation approaches rely on flexible and multifunct

26 , which we have termed electrochemical phase interrogation, as a means of collecting high time resolu

27 Upon the fluorescence interrogation at the single cell level, individual cells

28 or entities diagnosed in children, including interrogations at the level of the genome, epigenome, an

29 such as human norovirus (HuNoV) have defied interrogation because they were previously unculturable.

30 Nevertheless, device interrogation before and after MRI remains mandatory due

31 mperature, enabling comprehensive structural interrogation by (15) N NMR and IR spectroscopy, and sin

32 t represents a global baseline available for interrogation by future microbial ecology studies.

33 ogical specimens (e.g., microalgae) enabling interrogation by Raman microspectroscopy.

34 Furthermore, optogenetic interrogations demonstrate that these neurons play a piv

35 by clinicopathological criteria followed by interrogation for the presence of minimal/measurable res

36 Molecular interrogation further reveals the disruptive reality tha

37 ion has been achieved comparing to solely EC interrogation, i.e., the grafting process of biotin and

38 Transesophageal echocardiography and balloon interrogation identified 60% of the patients with sinus

39 formation from image data, allows for tissue interrogation in a way that was not previously possible.

40 We pursued genome-wide interrogation in Stage 1 studies (N = 117 438) and follo

41 ing this genetic marker offers direction for interrogation in subsequent genomic and experimental stu

42 procedural success was tracked by pacemaker interrogation in the atrioventricular junction group, ti

43 D-19 outcomes in our study will need further interrogation in tumor-specific cohorts.

44 fibres allows nitric oxide-mediated neuronal interrogation in vivo.

45 ogies have enabled an unprecedented level of interrogation into the impact of DNA variation (genotype

46 o fabricate simple MCF interferometers whose interrogation is carried out with light sources, detecto

47 oviruses (ERVs), a TE subclass, experimental interrogation is constrained as many are primate-specifi

48 This new method of tissue interrogation, known as dynamic biochemical tissue analy

49 anism, we believe that electrochemical phase interrogation may prove generalizable toward subsecond m

50 The immunosensor uses wavelength interrogation method and a strong linear relationship (R

51 Systematic interrogation of 274 splicing-regulatory genes (SRGs) un

52 Through interrogation of a genome-wide association study, we exa

53 The creation and interrogation of a microbial rhodopsin mimic, based on a

54 Preparation and electrochemical interrogation of a novel redox active progesterone deriv

55 parietal cortex is modulated during saccadic interrogation of a simple visual scene.

56 tention networks changed during the saccadic interrogation of a simple visual scene.

57 ansgenic mouse line that enabled the genetic interrogation of a subpopulation of claustral glutamater

58 e unprecedented size of this dataset allowed interrogation of additional questions-for example, we fi

59 This study represents the first metagenomic interrogation of Antarctic permafrost and polar cryptoen

60 Here we conduct an in-depth interrogation of associations between genetic variation,

61 We used interrogation of available genomic and chromosome confor

62 roach that incorporates applied genomics and interrogation of B cell signaling pathways may offer an

63 erimental artefacts, especially for in vitro interrogation of bioactivity and mechanisms of action; r

64 It is particularly relevant for interrogation of biological phenomena in data derived fr

65 terns enabling differential and reproducible interrogation of biological samples, including deep samp

66 r vibrations and is perfectly suited for the interrogation of biological samples.

67 sment of physiology and function, toward the interrogation of biology and molecular pathways.

68 resonator arrays and nanodiscs enables rapid interrogation of biomolecular binding interactions at mo

69 Comprehensive interrogation of biosynthesis activities during transien

70 ly, we present a framework to facilitate the interrogation of both pathogenicity and the functional e

71 ience tools that have enabled high-precision interrogation of brain circuitry linked with REM sleep c

72 issue response to achieve chronic multimodal interrogation of brain circuits with high fidelity.

73 Balloon interrogation of cavoatrial junction confirmed complete

74 y different methods, and also allows for the interrogation of cell-to-cell variability.

75 tivity gains that allow disease tracking and interrogation of cellular metabolism by magnetic resonan

76 ngle-nucleus RNA-seq (snRNA-seq) enables the interrogation of cellular states in complex tissues that

77 plicable to a range of systems, enabling the interrogation of changes in a protein's conformation req

78 Furthermore, interrogation of chemotherapy-induced PD-L1 expression i

79 In vivo interrogation of chromatin architecture and genome-wide

80 nformation capture conditions, which enables interrogation of chromatin architecture focused around a

81 ient biopsies to provide models that support interrogation of CIN mechanisms in cells not extensively

82 roduce a flexible method for high-resolution interrogation of circuit function, which combines simult

83 ome, and is a community resource for further interrogation of clinical and molecular associations.

84 The interrogation of complex biological pathways demands div

85 ineer the human genome for robust functional interrogation of complex biological processes.

86 has enabled the development of tools for the interrogation of complex biological systems.

87 ch technically challenge accurate functional interrogation of contractile parameters in beating cells

88 ded state observed in fluorescence analysis, interrogation of current versus time traces obtained fro

89 Comprehensive MR interrogation of DBP required us to also model systolic

90 Spatial information is critical to the interrogation of developmental and tissue-level regulati

91 s studies and computationally through direct interrogation of different modes of interaction using al

92 Interrogation of disease-relevant cellular and molecular

93 filing (MCAP), an approach for combinatorial interrogation of double knockouts in vivo.

94 in silico drug target prioritization through interrogation of drug target databases.

95 Mechanistic interrogation of each key step of the methodology inform

96 Our study establishes a framework for interrogation of enhancer function in living cells and s

97 R screening method, Genome engineering-based Interrogation of Enhancers (GenIE), which assesses the e

98 rference (RNAi) enables flexible and dynamic interrogation of entire gene families or essential genes

99 Interrogation of environmental microbial communities com

100 e basis for a new era of "ensemble-function" interrogation of enzymes.

101 sequencing assays allow for the simultaneous interrogation of extended sets of somatic single-nucleot

102 is system, we initiated a systematic genetic interrogation of families with isolated GnRH deficiency

103 throughput that permits a systematic genetic interrogation of flies' ability to learn spatial tasks.

104 4-ETV6 was exclusively detected in TNBC, and interrogation of four independent patient cohorts detect

105 a comprehensive comparative transcriptomics interrogation of gene expression among floral organs of

106 tute a comprehensive toolbox that allows for interrogation of gene function and modulation of the cel

107 In the context of multicellular organisms, interrogation of gene function is greatly facilitated by

108 Genome-wide CRISPR screens enable systematic interrogation of gene function.

109 echnology enables high-throughput functional interrogation of genes recurrently mutated in DLBCL.

110 s are needed to model CRISPR screen data for interrogation of genetic elements that alter reporter ge

111 Interrogation of genome-wide gene expression in virgin a

112 new species will pave the way toward pooled interrogation of genotype-to-phenotype relationships in

113 egies, and provides new tools for functional interrogation of gliomagenesis.

114 lying severe asthma by an unbiased, detailed interrogation of global gene expression.Methods: BAL cel

115 Interrogation of head and neck squamous cell carcinoma (

116 h post-marketing surveillance or through the interrogation of healthcare databases.

117 Interrogation of hematopoietic tissue at the clonal leve

118 gh-throughput identification and mechanistic interrogation of HIV host factors in primary CD4(+) T ce

119 atomical map to permit molecular and genetic interrogation of how the neuronal components of a circui

120 Interrogation of human cancer gene expression data revea

121 mere-regulating therapeutics and accelerates interrogation of human cardiac genetic variants.

122 proach will enable molecular and mechanistic interrogation of human-restricted enteric pathogens.

123 experimentally validated by domain-specific interrogation of hydration with salt, which probed the c

124 ic resonance (DT-CMR) may enable noninvasive interrogation of in vivo cardiac microstructural dynamic

125 Consequently, direct interrogation of intact antibodies or F(ab')2 and Fab fr

126 ing of patients with COVID-19 allows for the interrogation of interactions between antibody isotypes

127 Due to the heterogeneity of these systems, interrogation of interfacial activity at nanometer lengt

128 l and dynamical properties, allowing for the interrogation of its role in, for instance, protein stab

129 By interrogation of kinome activity through an unbiased scr

130 Interrogation of knockout mouse phenotype resources prov

131 Interrogation of known transcription factor-lncRNA inter

132 ings provide a basis for the molecular level interrogation of labile SOM and C-cycling processes in s

133 od products after CTC enrichment, permitting interrogation of larger blood volumes than classic phleb

134 or optical imaging, where fully non-invasive interrogation of living specimens is critical.

135 e been invented to aid the visualization and interrogation of MCSs in both fixed and living cells.

136 istry-based enrichment strategy, DIMEN (deep interrogation of metabolism via enrichment), that we app

137 old-DNA affinity interaction, (ii) selective interrogation of methylation sites in adsorbed DNA via m

138 t findings, including the identification and interrogation of modifications within and proximal to th

139 in recent decades have facilitated a deeper interrogation of molecular processes in the human brain.

140 entification, annotation, visualization, and interrogation of multiscale network communities, accessi

141 Interrogation of murine cytomegalovirus (MCMV)-encoded c

142 Thus, synthetic optogenetics facilitates interrogation of native neuronal signaling mechanisms.

143 le of precise extracellular sequences is the interrogation of naturally occurring missense mutations.

144 g the 1970s and beyond set the stage for the interrogation of nearly every step in the reproductive c

145 lly implantable subdermally to allow for the interrogation of neural dynamics in freely behaving subj

146 Optogenetic interrogation of neural pathways relies on delivery of l

147 Such a tool will be of use in the molecular interrogation of neurological and psychiatric disorders,

148 odels provides an important path forward for interrogation of neuron-glia interactions.

149 ion with focused light beams, enable precise interrogation of neuronal function, even at the level of

150 array (MEA) to enable noninvasive long-term interrogation of neuronal networks.

151 types and provide a platform for systematic interrogation of normal and disease states of neurons.

152 offer investigators a toolkit for functional interrogation of not only protein-coding genes but also

153 t cytogenetic events, and allows for further interrogation of novel disease biology.

154 web-based platform that facilitates the easy interrogation of omics datasets holistically to improve

155 Furthermore, continued interrogation of oncogenes in benign developmental disor

156 We therefore hypothesize that rigorous interrogation of other types of genomic changes, e.g. tr

157 This is optimally done by interrogation of paired H chain V region (VH) and L chai

158 rformed global quantitative phosphoproteomic interrogation of PD-1 signaling in T cells.

159 The Omni-ATAC protocol enables the interrogation of personal regulomes in tissue context an

160 n of cell signaling, as well as non-invasive interrogation of physiological processes with high preci

161 tic tissue slices is a powerful tool for the interrogation of physiology and pathology in an in vitro

162 in vitro experimental systems that allow for interrogation of polygenic psychiatric disease risk to s

163 ovided 1 new diagnostic finding, and allowed interrogation of posited disease genes.

164 amming thus enables molecular and functional interrogation of preleukemic clonal evolution, identifyi

165 will facilitate hypothesis-driven functional interrogation of protease-specific substrate cleavage an

166 probes into proteomic workflows enables the interrogation of protein activity, rather than abundance

167 sponses can be particularly effective in the interrogation of protein signaling, as they can replace

168 in the last 10 years describing the in vitro interrogation of proteins recognizing carbohydrate ligan

169 This platform, which facilitates deep interrogation of proteoform primary structure, is highly

170 ance to EGFR TKI therapy was investigated by interrogation of public databases and a clinical cohort

171 les simultaneous fluorescence and absorbance interrogation of rapidly moving droplets in a fully auto

172 comes of CRISPR/Cas9 editing make functional interrogation of rare LT-HSCs challenging.

173 e here a technique which is suitable for the interrogation of regions at specified distances below th

174 (DHFR) ligand-protein conformations, allows interrogation of regions unresolvable by other technique

175 a non-invasive method that enables arbitrary interrogation of relative pressures throughout an imaged

176 sed multiplex strategy for direct functional interrogation of RNA cis-regulatory elements in a native

177 evelop selective chemical probes that enable interrogation of RNA structure and function, and describ

178 rom novel X-ray therapy techniques to active interrogation of sensitive materials, by making them acc

179 CryptSplice interrogation of sequence data from six individuals with

180 malian cells has hindered fast iteration and interrogation of sequence space needed to identify new R

181 uld drive a pathogen to colonize new niches, interrogation of sequenced E. coli O157:H7 genomes showe

182 n of Mt/AFM-SECM enables the electrochemical interrogation of several hundreds of individual nanodots

183 sets to make them more readily available for interrogation of sex differences.

184 Interrogation of single SFs with subcellular laser ablat

185 for high-throughput quantitative volumetric interrogation of spatially-irregular and friable tissue

186 EMG recordings, thus allowing direct in vivo interrogation of spinal motor neuron activity.

187 Native mass spectrometry (MS) allows the interrogation of structural aspects of macromolecules in

188 Extensive interrogation of structure-activity relationships (SARs)

189 Leading optical atomic clocks rely on the interrogation of such transitions in either single ions

190 and non-contact FDTI method allows for rapid interrogation of suspicious lesions and longitudinal cha

191 mutant as a monogenic model for mechanistic interrogation of T2DM phenotypes.

192 Locus-specific interrogation of target genes employing functional probe

193 d technique that permits the pharmacological interrogation of targeted neural populations in freely m

194 Interrogation of TCGA and GEO public datasets supports t

195 y, AK023948 is upregulated in breast cancer; interrogation of TCGA data set indicates that upregulati

196 input CUT&RUN (uliCUT&RUN) therefore enables interrogation of TF binding from rare cell populations o

197 Molecular interrogation of the Abeta plaque environment revealed e

198 The interrogation of the accelerometer was carried out by a

199 ks (OLCs) is limited both by the interrupted interrogation of the atomic system by the local-oscillat

200 Interrogation of the biological properties of wild-type

201 In silico interrogation of the Broad Institute's Connectivity Map

202 Interrogation of The Cancer Genome Atlas (TCGA) data sho

203 ompared to normal pancreatic tissue based on interrogation of The Cancer Genome Atlas (TCGA) pancreat

204 te, time-dependent density functional theory interrogation of the complexes reveals excited states wi

205 Interrogation of the contributions of individual immune

206 open access, web-based interface for further interrogation of the data.

207 Interrogation of the dataset identified sequence-based c

208 However, the metabolic interrogation of the developing cerebellum during the ea

209 Interrogation of the F. alocis genome identified the HMP

210 orm enables large-scale electrophysiological interrogation of the fast dynamics and long-timescale ev

211 These behavioral paradigms set the stage for interrogation of the fly brain circuitry underlying flex

212 In vivo interrogation of the function of genes implicated in tum

213 ic mapping of genetic interactions (GIs) and interrogation of the functions of sizable genomic segmen

214 Interrogation of the gene networks regulated by PRH and

215 from cDNAs, thus permitting reverse genetic interrogation of the HAZV replication cycle.

216 he HOXA9 reporter facilitated the functional interrogation of the HOXA9 regulome and has advanced our

217 ed to customize a capture panel for targeted interrogation of the human sperm methylome and test its

218 High-throughput TCR sequencing allows interrogation of the human TCR repertoire, potentially c

219 all, our analysis represents a comprehensive interrogation of the impact of retrotransposition on pro

220 treatment with Rova-T based on a noninvasive interrogation of the in vivo status of DLL3 expression u

221 Biochemical interrogation of the inactive D178N protein found no fol

222 Hydrogen-deuterium exchange MS-mediated interrogation of the intrinsic dynamics of these enzymes

223 ising transcriptome subsets, enabling deeper interrogation of the isolated molecules by another round

224 tion of these residues will enable the broad interrogation of the kinome and its inhibitors.

225 However, direct interrogation of the link between this putative synaptic

226 Interrogation of the lipidomics signature revealed abnor

227 g immune response were largely developed for interrogation of the local reaction.

228 Biophysical interrogation of the mutant variants revealed novel mech

229 ool for efficient, low-cost, high throughput interrogation of the P. falciparum genome, and can be ta

230 Interrogation of the pharmacogenomic landscape of LIMORE

231 atty acid synthesis was investigated by: (a) interrogation of the prostate cancer The Cancer Genome A

232 rimarily on genetic information whereas deep interrogation of the proteome has remained out of reach.

233 This enabled interrogation of the relationship among EBV latency gene

234 the SARS-CoV-2 genome to facilitate precise interrogation of the SARS-CoV-2-specific CD4(+) T cell r

235 Interrogation of the single-cell transcriptomes revealed

236 e exposure in mice, enabling pharmacological interrogation of the specificity of the offspring respon

237 ere we present a biophysical and biochemical interrogation of the structure of the full length CTD of

238 ross multiple length- and time-scales allows interrogation of the structure-property relationships in

239 tional modes, leads to serious drawbacks for interrogation of the trapped phonons, including limited

240 ve inherent limits for the understanding and interrogation of the underlying in vivo mechanisms due t

241 Interrogation of the underlying neural circuitry reveale

242 terogeneity of binding lifetimes enables the interrogation of the various intermediate states formed

243 Our interrogation of the whole-genome sequencing data for 21

244 tracing of mPFC projections and optogenetic interrogation of their synaptic connections with neurons

245 ynthetic substrate supported membrane, allow interrogation of these aspects of receptor signaling.

246 n, preclinical models of ELNs are needed for interrogation of these chemokines.

247 nia alvei Subsequent genetic and biochemical interrogation of these isolates raised concerns about th

248 one of the key experimental methods for the interrogation of these materials, a rigorous bridge betw

249 The need for continued interrogation of these mechanisms (both known and those

250 Most often, the interrogation of these sensors has relied on voltammetri

251 fewer computational tools exist for specific interrogation of this space.

252 tions to different nuclei, but comprehensive interrogation of transcriptional heterogeneity within mu

253 Herein, we perform an unbiased interrogation of tumor mesenchymal cells, delineating th

254 Systematic interrogation of tumor-infiltrating lymphocytes is key t

255 ts where these neutrons were used for active interrogation of uranium and plutonium, we observed beta

256 r-associated USP22 upregulation and unbiased interrogation of USP22-regulated functions in vitro demo

257 gs, an important class of chemical tools for interrogation of various biological targets.

258 Raman spectroscopy also allows simultaneous interrogation of various pigments in plants.

259 Optical interrogation of voltage in deep brain locations with ce

260 lastoma on the basis of rigorous statistical interrogation of what is, to the best of our knowledge,

261 physiological screening and other functional interrogations of neuronal networks.

262 ivity or filament formation and allowing for interrogations of respiratory syncytial virus virion ass

263 cellularized engineered tissues, and assist interrogations of the interplay between mass transport a

264 of kinases would enable fine spatiotemporal interrogation or manipulation of these various functions

265 All participants had device interrogations performed before and after each MRI.

266 We screened the Mechanism Interrogation Plate (MIPE) library, the National Center

267 The detailed description of DNA interrogation presented here suggests strategies for imp

268 at can deliver and record light in a precise interrogation region of a microfluidic channel.

269 Transcriptomic profiling and biochemical interrogation revealed a role for DHX37 in modulating NF

270 Gene expression interrogation revealed that IFN pathway was grossly upre

271 Genomic and molecular interrogation reveals an atypical VEGF-based vasculogene

272 Surface interrogation scanning electrochemical microscopy (SI-SE

273 ed period in culture for the high-throughput interrogation (several thousand samples per day) of whol

274 After almost a century of scientific interrogation, significant progress has been made in und

275 followed by reversible transitions into DNA interrogation states.

276 ht to elucidate the mechanism of initial DNA interrogation steps that precede the pairing of target D

277 , chemogenetic, genetic, and pharmacological interrogation suggested that downregulation of cortico-S

278 ngle cell label-free multi parameter optical interrogation system can detect endothelial cell and end

279 al impedance spectroscopy was employed as an interrogation technique in order to establish optimum bi

280 inity pulldown, a gold-standard in vitro PPI interrogation technique, to perform nanoscale pulldowns

281 ic cell type for transcriptome and epigenome interrogation that decreases dependency on transgenic an

282 Interrogation through the Free-Wilson analysis highlight

283 ranscriptomic, DNA-occupancy, and epigenomic interrogation throughout the reprogramming process.

284 To achieve very high sensitivities, the interrogation time has to be very long, and consequently

285 the mode of an optical cavity, we realize an interrogation time of 20 seconds.

286 , however, has been limited by the available interrogation time of freely falling atoms in a gravitat

287 Combined with the long interrogation times afforded by ion traps, a broad range

288 d to result in compact devices with extended interrogation times and therefore increased sensitivity.

289 , other genes required meticulous functional interrogation to explain their contribution to PHTS-rela

290 both prediction algorithms and experimental interrogations to understand pathophysiology of K(v)7-as

291 A whole genome methylation interrogation using the Illumina HumanMethylation 450 ar

292 combination of computational and functional interrogations, using statistical coupling analysis and

293 nickel-containing intermediates, as well as interrogation via EPR spectroscopy, UV-vis spectroscopy,

294 reports and brain tissue were available for interrogation was established.

295 Through systematic interrogation, we find that protein termini can be posit

296 Through combinatorial interrogation, we find that simultaneous repression of m

297 ould be revealed by its response to repeated interrogation with a laser system, enabling the developm

298 degrees C for >=1 h), followed by reprobing (interrogation with additional antibody probes).

299 sophageal echocardiography underwent balloon interrogation with monitoring of right upper pulmonary v

300 s reconstituted on such arrays are ideal for interrogation with single-molecule techniques.